Research Topics
| Michael I TrenellSummaryAffiliation: University of Newcastle Country: UK Publications
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Detail Information
Publications
Increased daily walking improves lipid oxidation without changes in mitochondrial function in type 2 diabetesMichael I Trenell
Diabetes Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK
Diabetes Care 31:1644-9. 2008..To determine whether increased daily physical activity improves mitochondrial function and/or lipid oxidation in type 2 diabetes...
Supplemental oxygen and muscle metabolism in mitochondrial myopathy patientsMichael I Trenell
Department of Neurogenetics, Kolling Institute for Medical Research, Sydney, Australia
Eur J Appl Physiol 99:541-7. 2007..05). We conclude that oxygen therapy is associated with significant improvements in muscle metabolism in patients with MM. These data suggest that patients with MM could benefit from therapies which improve the provision of oxygen...- Influence of constant positive airway pressure therapy on lipid storage, muscle metabolism and insulin action in obese patients with severe obstructive sleep apnoea syndromeM I Trenell
Woolcock Institute of Medical Research, Royal Prince Alfred and Royal North Shore Hospitals and University of Sydney, NSW, Australia
Diabetes Obes Metab 9:679-87. 2007..To observe the effect of constant positive airway pressure (CPAP) therapy on regional lipid deposition, muscle metabolism and glucose homeostasis in obese patients with obstructive sleep apnoea syndrome (OSAS)... - Effect of high and low glycaemic index recovery diets on intramuscular lipid oxidation during aerobic exerciseMichael I Trenell
Diabetes Research Group and Newcastle Magnetic Resonance Centre, School of Clinical Medical Sciences, Newcastle University, Newcastle upon Tyne, UK
Br J Nutr 99:326-32. 2008..05 respectively). No other differences were significant. The findings suggest that HGI carbohydrates reduce NEFA availability during exercise and increase reliance on IMCL as a substrate source during moderate intensity exercise... 
Relationship between peak cardiac pumping capability and indices of cardio-respiratory fitness in healthy individualsDjordje G Jakovljevic
Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK
Clin Physiol Funct Imaging 32:388-93. 2012....- Comparison of cardiac output determined by bioimpedance and bioreactance methods at rest and during exerciseDjordje G Jakovljevic
MoveLab Physical Activity and Exercise Research, MRC Centre for Brain Ageing and Vitality, Newcastle University, Newcastle upon Tyne, UK
J Clin Monit Comput 26:63-8. 2012..In contrast with bioimpedance, bioreactance cardiac outputs are similar to those estimated from measured oxygen consumption... - Aerobic exercise and muscle metabolism in patients with mitochondrial myopathyMichael I Trenell
School of Molecular and Microbial Bioscience, University of Sydney, Sydney, Australia
Muscle Nerve 33:524-31. 2006..Exercise therapy can assist in improving mitochondrial function in MM patients... - Submaximal exercise testing predicts perioperative hospitalization after aortic aneurysm repairJames M Prentis
Department of Perioperative and Critical Care Medicine, The Freeman Hospital, and the Institute of Cellular Medicine, Biomedical Research Centre for Ageing and Age Related Diseases, Newcastle University, Newcastle upon Tyne, United Kingdom
J Vasc Surg 56:1564-70. 2012..This study assessed whether preoperative cardiopulmonary exercise testing (CPET) could be used to predict morbidity and hospital length of stay (LOS) after aortic aneurysm repair... - Discrepancy between cardiac and physical functional reserves in strokeDjordje G Jakovljevic
Newcastle University, Newcastle upon Tyne, NE2 4HH, UK
Stroke 43:1422-5. 2012..This study defines (1) whether exercise capacity is limited by the cardiovascular system (oxygen supply) or skeletal muscles (oxygen utilization); and (2) cardiac function and pumping capability in people with stroke... - Loss of capacity to recover from acidosis on repeat exercise in chronic fatigue syndrome: a case-control studyDavid E J Jones
Institute of Cellular Medicine Newcastle, Newcastle University, Newcastle, UK
Eur J Clin Invest 42:186-94. 2012..Chronic fatigue syndrome (CFS) patients frequently describe difficulties with repeat exercise. Here, we explore muscle bioenergetic function in response to three bouts of exercise... - Lifestyle interventions for the treatment of non-alcoholic fatty liver disease in adults: a systematic reviewChristian Thoma
Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK
J Hepatol 56:255-66. 2012..Limited data also suggest that lifestyle interventions may hold benefits for histopathology... - Resistance exercise reduces liver fat and its mediators in non-alcoholic fatty liver disease independent of weight lossKate Hallsworth
Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK2NIHR Biomedical Research Centre for Ageing and Age related Disease, Newcastle University, Newcastle upon Tyne, UK
Gut 60:1278-83. 2011..Aerobic exercise is not well sustained and the effectiveness of the better tolerated resistance exercise upon liver lipid and mediators of liver lipid has not been assessed... - Resistance exercise improves autonomic regulation at rest and haemodynamic response to exercise in non-alcoholic fatty liver diseaseDjordje G Jakovljevic
Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, U K
Clin Sci (Lond) 125:143-9. 2013..Resistance exercise therapy seems to improve autonomic and submaximal exercise haemodynamic regulation in NAFLD. Further studies are required to define its role in clinical management of the condition... - Physical activity, sedentary behaviour and metabolic control following stroke: a cross-sectional and longitudinal studySarah A Moore
Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, United Kingdom
PLoS ONE 8:e55263. 2013..We assessed physical activity and sedentary behaviour at three time points following stroke compared to a healthy control group... - Measuring energy expenditure after stroke: validation of a portable deviceSarah A Moore
Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK
Stroke 43:1660-2. 2012..This study validates a portable multisensor array for measuring free-living total energy expenditure compared with a gold standard method (doubly labeled water) in individuals with stroke... - Submaximal cardiopulmonary exercise testing predicts 90-day survival after liver transplantationJames M Prentis
Department of Perioperative and Critical Care Medicine, Freeman Hospital, Newcastle upon Tyne, UK
Liver Transpl 18:152-9. 2012..In conclusion, the preoperative cardiorespiratory reserve (as defined by CPET) is a sensitive and specific predictor of early survival after liver transplantation. The predictive value of CPET requires further evaluation... - Changing physical activity behavior in type 2 diabetes: a systematic review and meta-analysis of behavioral interventionsLeah Avery
Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK
Diabetes Care 35:2681-9. 2012..However, little is known about how clinical teams should support adults with type 2 diabetes to achieve and sustain a physically active lifestyle... - Effects of 8 weeks of continuous positive airway pressure on abdominal adiposity in obstructive sleep apnoeaSheila Sivam
Sleep and Circadian Research Group, Woolcock Institute of Medical Research, PO Box M77, Missenden Road, NSW 2050, Australia
Eur Respir J 40:913-8. 2012..Longer duration of CPAP use may be necessary to demonstrate a difference... - Cardiomyopathy is common in patients with the mitochondrial DNA m.3243A>G mutation and correlates with mutation loadKieren G Hollingsworth
Newcastle Magnetic Resonance Centre, Institute of Cellular Medicine, Newcastle University, Campus for Ageing and Vitality, NE4 5PL, UK
Neuromuscul Disord 22:592-6. 2012..3243A>G. The early detection of cardiac dysfunction with MRI opens up opportunities to prevent heart failure in these patients through early intervention... - Cardiorespiratory Fitness Is Associated with Hard and Light Intensity Physical Activity but Not Time Spent Sedentary in 10-14 Year Old Schoolchildren: The HAPPY StudySarah J Denton
Institute for Sport and Physical Activity Research, University of Bedfordshire, Bedford, United Kingdom Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom
PLoS ONE 8:e61073. 2013..The purpose of this study was to assess how sedentary behaviour and different physical activity subcomponents are associated with 10-14 year-old schoolchildren's cardiorespiratory fitness... - Relationship between peak cardiac pumping capability and selected exercise-derived prognostic indicators in patients treated with left ventricular assist devicesDjordje G Jakovljevic
Medical School, Newcastle University, Newcastle upon Tyne, UK
Eur J Heart Fail 13:992-9. 2011.... - Sleep and metabolic control: waking to a problem?Michael I Trenell
Sleep and Circadian Research Group, Woolcock Institute of Medical Research, Sydney, NSW, Australia
Clin Exp Pharmacol Physiol 34:1-9. 2007..The challenge ahead is to identify how sex differences, ageing and obesity could potentially influence the relationship between sleep and metabolism... - The effect of phosphate loading on erythrocyte 2,3-bisphosphoglycerate levelsKyla Bremner
Department of Biochemistry, University of Sydney, Sydney, Australia
Clin Chim Acta 323:111-4. 2002..03). There is no relation between [2,3-BPG] and plasma [P(i)]. CONCLUSIONS: Phosphate loading increases both plasma and erythrocyte phosphate pools and the rise in [2,3-BPG] is probably a consequence of the rise in cell [P(i)]... - Dietary glycemic index influences lipid oxidation but not muscle or liver glycogen oxidation during exerciseE J Stevenson
Northumbria University, Newcastle upon Tyne, NE1 8ST, UK
Am J Physiol Endocrinol Metab 296:E1140-7. 2009..High-GI recovery diets reduce NEFA availability and increase reliance on IMCL during moderate-intensity exercise. Skeletal muscle and liver glycogen storage or usage are not affected by the GI of an acute recovery diet... - Differences in metabolites in pain-processing brain regions in patients with diabetes and painful neuropathyLea Sorensen
Diabetes Centre, Royal Prince Alfred Hospital, Camperdown, Australia
Diabetes Care 31:980-1. 2008..This study used (1)H-MRS to examine the brain in subjects with or without painful diabetic neuropathy... - Exercise and myotonic dystrophy: a 31P magnetic resonance spectroscopy and magnetic resonance imaging case studyMichael I Trenell
Ann Neurol 59:871-2. 2006 - Exercise capacity and quadriceps muscle metabolism following training in subjects with COPDZoe J McKeough
Department of Respiratory Medicine, Level 11 West, Building 75, Royal Prince Alfred Hospital, Missenden Rd, Camperdown, NSW, Australia 2050
Respir Med 100:1817-25. 2006..007). Sixteen sessions of exercise training, performed twice weekly, increased exercise capacity as well as quadriceps mitochondrial capacity, CSA and strength in the subjects with COPD...