Michael I Trenell

Summary

Affiliation: University of Newcastle
Country: UK

Publications

  1. pmc Increased daily walking improves lipid oxidation without changes in mitochondrial function in type 2 diabetes
    Michael I Trenell
    Diabetes Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK
    Diabetes Care 31:1644-9. 2008
  2. ncbi request reprint Effect of high and low glycaemic index recovery diets on intramuscular lipid oxidation during aerobic exercise
    Michael I Trenell
    Diabetes Research Group and Newcastle Magnetic Resonance Centre, School of Clinical Medical Sciences, Newcastle University, Newcastle upon Tyne, UK
    Br J Nutr 99:326-32. 2008
  3. ncbi request reprint Influence of constant positive airway pressure therapy on lipid storage, muscle metabolism and insulin action in obese patients with severe obstructive sleep apnoea syndrome
    M I Trenell
    Woolcock Institute of Medical Research, Royal Prince Alfred and Royal North Shore Hospitals and University of Sydney, NSW, Australia
    Diabetes Obes Metab 9:679-87. 2007
  4. ncbi request reprint Supplemental oxygen and muscle metabolism in mitochondrial myopathy patients
    Michael I Trenell
    Department of Neurogenetics, Kolling Institute for Medical Research, Sydney, Australia
    Eur J Appl Physiol 99:541-7. 2007
  5. pmc Concentric hypertrophic remodelling and subendocardial dysfunction in mitochondrial DNA point mutation carriers
    Matthew G D Bates
    Wellcome Trust Centre for Mitochondrial Research, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK
    Eur Heart J Cardiovasc Imaging 14:650-8. 2013
  6. doi request reprint Cardiac structure and function are altered in adults with non-alcoholic fatty liver disease
    Kate Hallsworth
    Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK
    J Hepatol 58:757-62. 2013
  7. doi request reprint Relationship between peak cardiac pumping capability and indices of cardio-respiratory fitness in healthy individuals
    Djordje G Jakovljevic
    Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK
    Clin Physiol Funct Imaging 32:388-93. 2012
  8. doi request reprint Comparison of cardiac output determined by bioimpedance and bioreactance methods at rest and during exercise
    Djordje G Jakovljevic
    MoveLab Physical Activity and Exercise Research, MRC Centre for Brain Ageing and Vitality, Newcastle University, Newcastle upon Tyne, UK
    J Clin Monit Comput 26:63-8. 2012
  9. ncbi request reprint Aerobic exercise and muscle metabolism in patients with mitochondrial myopathy
    Michael I Trenell
    School of Molecular and Microbial Bioscience, University of Sydney, Sydney, Australia
    Muscle Nerve 33:524-31. 2006
  10. pmc Physical activity, sedentary behaviour and metabolic control following stroke: a cross-sectional and longitudinal study
    Sarah A Moore
    Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, United Kingdom
    PLoS ONE 8:e55263. 2013

Detail Information

Publications34

  1. pmc Increased daily walking improves lipid oxidation without changes in mitochondrial function in type 2 diabetes
    Michael I Trenell
    Diabetes Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK
    Diabetes Care 31:1644-9. 2008
    ..To determine whether increased daily physical activity improves mitochondrial function and/or lipid oxidation in type 2 diabetes...
  2. ncbi request reprint Effect of high and low glycaemic index recovery diets on intramuscular lipid oxidation during aerobic exercise
    Michael I Trenell
    Diabetes Research Group and Newcastle Magnetic Resonance Centre, School of Clinical Medical Sciences, Newcastle University, Newcastle upon Tyne, UK
    Br J Nutr 99:326-32. 2008
    ..05 respectively). No other differences were significant. The findings suggest that HGI carbohydrates reduce NEFA availability during exercise and increase reliance on IMCL as a substrate source during moderate intensity exercise...
  3. ncbi request reprint Influence of constant positive airway pressure therapy on lipid storage, muscle metabolism and insulin action in obese patients with severe obstructive sleep apnoea syndrome
    M I Trenell
    Woolcock Institute of Medical Research, Royal Prince Alfred and Royal North Shore Hospitals and University of Sydney, NSW, Australia
    Diabetes Obes Metab 9:679-87. 2007
    ..To observe the effect of constant positive airway pressure (CPAP) therapy on regional lipid deposition, muscle metabolism and glucose homeostasis in obese patients with obstructive sleep apnoea syndrome (OSAS)...
  4. ncbi request reprint Supplemental oxygen and muscle metabolism in mitochondrial myopathy patients
    Michael I Trenell
    Department of Neurogenetics, Kolling Institute for Medical Research, Sydney, Australia
    Eur J Appl Physiol 99:541-7. 2007
    ..05). We conclude that oxygen therapy is associated with significant improvements in muscle metabolism in patients with MM. These data suggest that patients with MM could benefit from therapies which improve the provision of oxygen...
  5. pmc Concentric hypertrophic remodelling and subendocardial dysfunction in mitochondrial DNA point mutation carriers
    Matthew G D Bates
    Wellcome Trust Centre for Mitochondrial Research, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK
    Eur Heart J Cardiovasc Imaging 14:650-8. 2013
    ..Screening strategies for cardiac disease are unclear. We investigated whether myocardial abnormalities could be identified in mitochondrial DNA mutation carriers without clinical cardiac involvement...
  6. doi request reprint Cardiac structure and function are altered in adults with non-alcoholic fatty liver disease
    Kate Hallsworth
    Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK
    J Hepatol 58:757-62. 2013
    ..This study aimed to address this by defining the effect of NAFLD on cardiac function, structure, and metabolism...
  7. doi request reprint Relationship between peak cardiac pumping capability and indices of cardio-respiratory fitness in healthy individuals
    Djordje G Jakovljevic
    Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK
    Clin Physiol Funct Imaging 32:388-93. 2012
    ....
  8. doi request reprint Comparison of cardiac output determined by bioimpedance and bioreactance methods at rest and during exercise
    Djordje G Jakovljevic
    MoveLab Physical Activity and Exercise Research, MRC Centre for Brain Ageing and Vitality, Newcastle University, Newcastle upon Tyne, UK
    J Clin Monit Comput 26:63-8. 2012
    ..In contrast with bioimpedance, bioreactance cardiac outputs are similar to those estimated from measured oxygen consumption...
  9. ncbi request reprint Aerobic exercise and muscle metabolism in patients with mitochondrial myopathy
    Michael I Trenell
    School of Molecular and Microbial Bioscience, University of Sydney, Sydney, Australia
    Muscle Nerve 33:524-31. 2006
    ..Exercise therapy can assist in improving mitochondrial function in MM patients...
  10. pmc Physical activity, sedentary behaviour and metabolic control following stroke: a cross-sectional and longitudinal study
    Sarah A Moore
    Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, United Kingdom
    PLoS ONE 8:e55263. 2013
    ..We assessed physical activity and sedentary behaviour at three time points following stroke compared to a healthy control group...
  11. doi request reprint Submaximal exercise testing predicts perioperative hospitalization after aortic aneurysm repair
    James M Prentis
    Department of Perioperative and Critical Care Medicine, The Freeman Hospital, and the Institute of Cellular Medicine, Biomedical Research Centre for Ageing and Age Related Diseases, Newcastle University, Newcastle upon Tyne, United Kingdom
    J Vasc Surg 56:1564-70. 2012
    ..This study assessed whether preoperative cardiopulmonary exercise testing (CPET) could be used to predict morbidity and hospital length of stay (LOS) after aortic aneurysm repair...
  12. pmc Hepatic cholesteryl ester accumulation in lysosomal acid lipase deficiency: non-invasive identification and treatment monitoring by magnetic resonance
    Peter E Thelwall
    Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK
    J Hepatol 59:543-9. 2013
    ..Secondly, we used MR spectroscopy to monitor the effects of an enzyme replacement therapy (ERT), sebelipase alfa (a recombinant human lysosomal acid lipase), on hepatic TG and CE content in the preclinical model...
  13. doi request reprint Resistance exercise improves autonomic regulation at rest and haemodynamic response to exercise in non-alcoholic fatty liver disease
    Djordje G Jakovljevic
    Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK
    Clin Sci (Lond) 125:143-9. 2013
    ..Resistance exercise therapy seems to improve autonomic and submaximal exercise haemodynamic regulation in NAFLD. Further studies are required to define its role in clinical management of the condition...
  14. doi request reprint Discrepancy between cardiac and physical functional reserves in stroke
    Djordje G Jakovljevic
    Newcastle University, Newcastle upon Tyne, NE2 4HH, UK
    Stroke 43:1422-5. 2012
    ..This study defines (1) whether exercise capacity is limited by the cardiovascular system (oxygen supply) or skeletal muscles (oxygen utilization); and (2) cardiac function and pumping capability in people with stroke...
  15. doi request reprint Loss of capacity to recover from acidosis on repeat exercise in chronic fatigue syndrome: a case-control study
    David E J Jones
    Institute of Cellular Medicine Newcastle, Newcastle University, Newcastle, UK
    Eur J Clin Invest 42:186-94. 2012
    ..Chronic fatigue syndrome (CFS) patients frequently describe difficulties with repeat exercise. Here, we explore muscle bioenergetic function in response to three bouts of exercise...
  16. pmc Effect of left ventricular assist device implantation and heart transplantation on habitual physical activity and quality of life
    Djordje G Jakovljevic
    Institute of Cellular Medicine, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom Electronic address
    Am J Cardiol 114:88-93. 2014
    ..Strategies targeting low levels of physical activity should now be explored to improve recovery of these patients. ..
  17. pmc Discrete gait characteristics are associated with m.3243A>G and m.8344A>G variants of mitochondrial disease and its pathological consequences
    Brook Galna
    Clinical Ageing Research Unit, Campus for Ageing and Vitality, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK
    J Neurol 261:73-82. 2014
    ..Discrete gait characteristics may help describe functional deficits in mitochondrial disease, enhance measures of disease severity and pathology, and could be used to document treatment effects of novel therapies. ..
  18. doi request reprint Lifestyle interventions for the treatment of non-alcoholic fatty liver disease in adults: a systematic review
    Christian Thoma
    Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK
    J Hepatol 56:255-66. 2012
    ..Limited data also suggest that lifestyle interventions may hold benefits for histopathology...
  19. pmc Resistance exercise reduces liver fat and its mediators in non-alcoholic fatty liver disease independent of weight loss
    Kate Hallsworth
    Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK2NIHR Biomedical Research Centre for Ageing and Age related Disease, Newcastle University, Newcastle upon Tyne, UK
    Gut 60:1278-83. 2011
    ..Aerobic exercise is not well sustained and the effectiveness of the better tolerated resistance exercise upon liver lipid and mediators of liver lipid has not been assessed...
  20. ncbi request reprint Impaired cardiopulmonary reserve in an elderly population is related to postoperative morbidity and length of hospital stay after radical cystectomy
    James M Prentis
    Department of Perioperative and Critical Care Medicine, Freeman Hospital, Newcastle upon Tyne, UK
    BJU Int 112:E13-9. 2013
    ....
  21. ncbi request reprint Submaximal cardiopulmonary exercise testing predicts 90-day survival after liver transplantation
    James M Prentis
    Department of Perioperative and Critical Care Medicine, Freeman Hospital, Newcastle upon Tyne, UK
    Liver Transpl 18:152-9. 2012
    ..In conclusion, the preoperative cardiorespiratory reserve (as defined by CPET) is a sensitive and specific predictor of early survival after liver transplantation. The predictive value of CPET requires further evaluation...
  22. doi request reprint Measuring energy expenditure after stroke: validation of a portable device
    Sarah A Moore
    Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK
    Stroke 43:1660-2. 2012
    ..This study validates a portable multisensor array for measuring free-living total energy expenditure compared with a gold standard method (doubly labeled water) in individuals with stroke...
  23. pmc Movement as Medicine for Type 2 Diabetes: protocol for an open pilot study and external pilot clustered randomised controlled trial to assess acceptability, feasibility and fidelity of a multifaceted behavioural intervention targeting physical activity in
    Leah Avery
    Institute of Cellular Medicine, William Leech Building, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK
    Trials 15:46. 2014
    ..However, it remains unclear what the optimal strategies are to increase PA behaviour in people with Type 2 diabetes in routine primary care...
  24. pmc Changing physical activity behavior in type 2 diabetes: a systematic review and meta-analysis of behavioral interventions
    Leah Avery
    Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK
    Diabetes Care 35:2681-9. 2012
    ..However, little is known about how clinical teams should support adults with type 2 diabetes to achieve and sustain a physically active lifestyle...
  25. ncbi request reprint Effects of 8 weeks of continuous positive airway pressure on abdominal adiposity in obstructive sleep apnoea
    Sheila Sivam
    Sleep and Circadian Research Group, Woolcock Institute of Medical Research, PO Box M77, Missenden Road, NSW 2050, Australia
    Eur Respir J 40:913-8. 2012
    ..Longer duration of CPAP use may be necessary to demonstrate a difference...
  26. pmc Cardiomyopathy is common in patients with the mitochondrial DNA m.3243A>G mutation and correlates with mutation load
    Kieren G Hollingsworth
    Newcastle Magnetic Resonance Centre, Institute of Cellular Medicine, Newcastle University, Campus for Ageing and Vitality, NE4 5PL, UK
    Neuromuscul Disord 22:592-6. 2012
    ..3243A>G. The early detection of cardiac dysfunction with MRI opens up opportunities to prevent heart failure in these patients through early intervention...
  27. pmc cardiorespiratory fitness is associated with hard and light intensity physical activity but not time spent sedentary in 10-14 year old schoolchildren: the HAPPY study
    Sarah J Denton
    Institute for Sport and Physical Activity Research, University of Bedfordshire, Bedford, United Kingdom
    PLoS ONE 8:e61073. 2013
    ..The purpose of this study was to assess how sedentary behaviour and different physical activity subcomponents are associated with 10-14 year-old schoolchildren's cardiorespiratory fitness...
  28. ncbi request reprint Sleep and metabolic control: waking to a problem?
    Michael I Trenell
    Sleep and Circadian Research Group, Woolcock Institute of Medical Research, Sydney, NSW, Australia
    Clin Exp Pharmacol Physiol 34:1-9. 2007
    ..The challenge ahead is to identify how sex differences, ageing and obesity could potentially influence the relationship between sleep and metabolism...
  29. ncbi request reprint The effect of phosphate loading on erythrocyte 2,3-bisphosphoglycerate levels
    Kyla Bremner
    Department of Biochemistry, University of Sydney, Sydney, Australia
    Clin Chim Acta 323:111-4. 2002
    ..Claimed effects of phosphate loading upon both exercise performance and erythrocyte [2,3-BPG] are inconsistent, and the basis of any change in [2,3-BPG] is unknown...
  30. doi request reprint Relationship between peak cardiac pumping capability and selected exercise-derived prognostic indicators in patients treated with left ventricular assist devices
    Djordje G Jakovljevic
    Medical School, Newcastle University, Newcastle upon Tyne, UK
    Eur J Heart Fail 13:992-9. 2011
    ....
  31. doi request reprint Dietary glycemic index influences lipid oxidation but not muscle or liver glycogen oxidation during exercise
    E J Stevenson
    Northumbria University, Newcastle upon Tyne, NE1 8ST, UK
    Am J Physiol Endocrinol Metab 296:E1140-7. 2009
    ..High-GI recovery diets reduce NEFA availability and increase reliance on IMCL during moderate-intensity exercise. Skeletal muscle and liver glycogen storage or usage are not affected by the GI of an acute recovery diet...
  32. ncbi request reprint Exercise and myotonic dystrophy: a 31P magnetic resonance spectroscopy and magnetic resonance imaging case study
    Michael I Trenell
    Ann Neurol 59:871-2. 2006
  33. ncbi request reprint Exercise capacity and quadriceps muscle metabolism following training in subjects with COPD
    Zoe J McKeough
    Department of Respiratory Medicine, Level 11 West, Building 75, Royal Prince Alfred Hospital, Missenden Rd, Camperdown, NSW, Australia 2050
    Respir Med 100:1817-25. 2006
    ..007). Sixteen sessions of exercise training, performed twice weekly, increased exercise capacity as well as quadriceps mitochondrial capacity, CSA and strength in the subjects with COPD...
  34. ncbi request reprint Differences in metabolites in pain-processing brain regions in patients with diabetes and painful neuropathy
    Lea Sorensen
    Diabetes Centre, Royal Prince Alfred Hospital, Camperdown, Australia
    Diabetes Care 31:980-1. 2008
    ..This study used (1)H-MRS to examine the brain in subjects with or without painful diabetic neuropathy...