Research Topics
Genomes and Genes | P TrayhurnSummaryAffiliation: University of Liverpool Country: UK Publications
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Publications
Expression and secretion of inflammation-related adipokines by human adipocytes differentiated in culture: integrated response to TNF-alphaBohan Wang
Neuroendocrine and Obesity Biology Unit, School of Clinical Sciences, University of Liverpool, Liverpool, UK
Am J Physiol Endocrinol Metab 288:E731-40. 2005....
Dysregulation of the expression and secretion of inflammation-related adipokines by hypoxia in human adipocytesBohan Wang
Obesity Biology Unit Liverpool Centre for Nutritional Genomics and Liverpool Obesity Research Network, School of Clinical Sciences, University Clinical Departments, University of Liverpool, Liverpool, UK
Pflugers Arch 455:479-92. 2007..Hypoxia may underlie the development of the inflammatory response in adipocytes, leading to obesity-associated diseases...
PCR arrays identify metallothionein-3 as a highly hypoxia-inducible gene in human adipocytesBohan Wang
Obesity Biology Unit, School of Clinical Sciences, University of Liverpool, Duncan Building, Liverpool L69 3GA, UK
Biochem Biophys Res Commun 368:88-93. 2008..MT-3 is a highly hypoxia-inducible gene in human adipocytes; the protein may protect adipocytes from hypoxic damage...- Adipose tissue and adipokines--energy regulation from the human perspectivePaul Trayhurn
Obesity Biology Unit, School of Clinical Sciences, University of Liverpool, Liverpool L69 3GA, UK
J Nutr 136:1935S-1939S. 2006..Although the focus remains very much on obesity in humans, the disorder and its sequelae are also a growing concern in companion animals... - Endocrine and signalling role of adipose tissue: new perspectives on fatP Trayhurn
Neuroendocrine and Obesity Biology Unit, Liverpool Centre for Nutritional Genomics, School of Clinical Sciences, University of Liverpool, Liverpool, UK
Acta Physiol Scand 184:285-93. 2005.... - Appetite and energy balance signals from adipocytesPaul Trayhurn
Obesity Biology Unit Liverpool Centre for Nutritional Genomics and Liverpool Obesity Research Network, School of Clinical Sciences, University of Liverpool, UK
Philos Trans R Soc Lond B Biol Sci 361:1237-49. 2006..Through leptin and the other adipokines it is evident that adipose tissue communicates extensively with other organs and plays a pervasive role in metabolic homeostasis... - The biology of obesityPaul Trayhurn
Neuroendocrine and Obesity Biology Unit, Liverpool Centre for Nutritional Genomics, School of Clinical Sciences, University of Liverpool, UK
Proc Nutr Soc 64:31-8. 2005..It has been suggested that inflammation in obesity is principally an adaptive response to hypoxia in clusters of adipocytes within the expanding adipose mass... 
Secreted proteins from adipose tissue and skeletal muscle - adipokines, myokines and adipose/muscle cross-talkPaul Trayhurn
Obesity Biology Unit, Institute of Ageing and Chronic Diseases, University of Liverpool, UK
Arch Physiol Biochem 117:47-56. 2011..For example, IL-6, secreted from myocytes may stimulate lipolysis in adipose tissue, while adipocyte-derived IL-6 may induce insulin resistance in muscle...- Adipocyte biologyP Trayhurn
Obesity Biology Unit, School of Clinical Sciences, University of Liverpool, Liverpool, UK
Obes Rev 8:41-4. 2007 - Adipose tissue in obesity--an inflammatory issuePaul Trayhurn
Neuroendocrinology and Obesity Biology Unit, Liverpool Centre for Nutritional Genomics, Division of Metabolic and Cellular Medicine, School of Clinical Sciences, University of Liverpool, Liverpool L69 3GA, United Kingdom
Endocrinology 146:1003-5. 2005 - Adipokines: inflammation and the pleiotropic role of white adipose tissuePaul Trayhurn
Neuroendocrine and Obesity Biology Unit, Liverpool Centre for Nutritional Genomics, School of Clinical Sciences, University of Liverpool, UK
Br J Nutr 92:347-55. 2004.... - Signalling role of adipose tissue: adipokines and inflammation in obesityP Trayhurn
Obesity Biology Unit, Liverpool Centre for Nutritional Genomics, School of Clinical Sciences, University of Liverpool, Duncan Building, Liverpool L69 3GA, UK
Biochem Soc Trans 33:1078-81. 2005..WAT is involved in extensive cross-talk with other organs and multiple metabolic systems through the various adipokines... - Hypoxia and the endocrine and signalling role of white adipose tissuePaul Trayhurn
Obesity Biology Research Unit, School of Clinical Sciences, University of Liverpool, University Clinical Departments, Liverpool, UK
Arch Physiol Biochem 114:267-76. 2008..Hypoxia also stimulates glucose transport by adipocytes and may have a pervasive effect on cell function within adipose tissue... - Hypoxia in adipose tissue: a basis for the dysregulation of tissue function in obesity?Paul Trayhurn
Obesity Biology Unit, School of Clinical Sciences, University of Liverpool, University Clinical Department, Duncan Building, Liverpool L69 3GA, UK
Br J Nutr 100:227-35. 2008.... - Leptin--a critical body weight signal and a "master" hormone?Paul Trayhurn
Liverpool Centre for Nutritional Genomics, Neuroendocrine and Obesity Biology Unit, Department of Medicine, University of Liverpool, University Clinical Departments, Liverpool L69 3GA, UK
Sci STKE 2003:PE7. 2003.... - The adipokine zinc-alpha2-glycoprotein (ZAG) is downregulated with fat mass expansion in obesityT Mracek
Obesity Biology Research Unit, School of Clinical Sciences, University of Liverpool, Liverpool, UK
Clin Endocrinol (Oxf) 72:334-41. 2010..The study also examined the association between ZAG and adiponectin expression in human adipose tissue, and whether ZAG modulates adiponectin secretion by human adipocytes... - Macrophage-secreted factors inhibit ZAG expression and secretion by human adipocytesD Gao
Obesity Biology Research Unit, School of Clinical Sciences, University of Liverpool, Liverpool L69 3GA, UK
Mol Cell Endocrinol 325:135-42. 2010..These findings suggest that macrophage-associated inflammation may play a significant role in the downregulation of ZAG in adipose tissue in obesity... - 11-Hydroxy-β-steroid dehydrogenase gene expression in canine adipose tissue and adipocytes: stimulation by lipopolysaccharide and tumor necrosis factor αV H Ryan
Department of Obesity and Endocrinology, School of Veterinary Science, University of Liverpool, Liverpool L69 3GA, United Kingdom
Domest Anim Endocrinol 41:150-61. 2011..The induction of 11β-HSD-1 expression, by the pro-inflammatory cytokine tumor necrosis factor α and by lipopolysaccharide may have implications for the pathogenesis of obesity and its associated diseases in the dog... - Improvement in insulin resistance and reduction in plasma inflammatory adipokines after weight loss in obese dogsA J German
Department of Veterinary Clinical Sciences, University of Liverpool, Neston, Wirral, United Kingdom
Domest Anim Endocrinol 37:214-26. 2009..Concurrent decreases in TNF-alpha and adipose tissue mass suggest that in dogs, as in humans, this adipokine may be implicated in the insulin resistance of obesity... - Enhanced ZAG production by subcutaneous adipose tissue is linked to weight loss in gastrointestinal cancer patientsT Mracek
Obesity Biology Research Unit, School of Clinical Sciences, University of Liverpool, Liverpool L69 3GA, UK
Br J Cancer 104:441-7. 2011..Profound loss of adipose tissue is a hallmark of cancer cachexia. Zinc-α2-glycoprotein (ZAG), a recently identified adipokine, is suggested as a candidate in lipid catabolism... - Adipose atrophy in cancer cachexia: morphologic and molecular analysis of adipose tissue in tumour-bearing miceC Bing
Obesity Biology Unit, Division of Metabolic and Cellular Medicine, School of Clinical Sciences, University of Liverpool, Liverpool L69 3GA, UK
Br J Cancer 95:1028-37. 2006..These results suggest that the tumour-induced impairment in the formation and lipid storing capacity of adipose tissue occurs in mice with cancer cachexia... - NGF gene expression and secretion by canine adipocytes in primary culture: upregulation by the inflammatory mediators LPS and TNFalphaV H Ryan
School of Clinical Sciences, University of Liverpool, Liverpool, UK
Horm Metab Res 40:861-8. 2008..Canine adipocytes appear highly sensitive to inflammatory stimuli... - Zinc-α2-glycoprotein: an adipokine modulator of body fat mass?C Bing
Obesity Biology Research Unit, School of Clinical Sciences, University of Liverpool, Liverpool, UK
Int J Obes (Lond) 34:1559-65. 2010..The present review summarizes these new perspectives of ZAG and the potential mechanisms by which it might modulate adipose tissue mass and function... - Zinc-alpha2-glycoprotein, a lipid mobilizing factor, is expressed and secreted by human (SGBS) adipocytesYi Bao
Neuroendocrine and Obesity Biology Unit, School of Clinical Sciences, University Clinical Departments, University of Liverpool, Liverpool L69 3GA, UK
FEBS Lett 579:41-7. 2005..ZAG is a novel adipokine, which may be involved in the local regulation of adipose tissue function... - Adipokine gene expression in dog adipose tissues and dog white adipocytes differentiated in primary cultureI Eisele
Neuroendocrine and Obesity Biology Unit, Liverpool Centre for Nutritional Genomics, School of Clinical Sciences, University of Liverpool, University Clinical Departments, Liverpool L69 3GA, United Kingdom
Horm Metab Res 37:474-81. 2005..Investigation of adipokine production and function will provide insight into the mechanisms involved in obesity-related pathologies in dogs and serve as a model for the related human diseases... - Upregulation of the expression of inflammatory and angiogenic markers in human adipocytes by a synthetic cannabinoid, JTE-907P González-Muniesa
Obesity Biology Research Unit, School of Clinical Sciences, University of Liverpool, UCD, Duncan Building, Liverpool, UK
Horm Metab Res 42:710-7. 2010..CB1 and TRPV1 receptors participate in the regulation of several inflammatory and angiogenic factors in human adipocytes, indicating their potential value as targets for the treatment of disorders related to obesity... - Regulation of haptoglobin gene expression in 3T3-L1 adipocytes by cytokines, catecholamines, and PPARgammaClaudia Oller do Nascimento
Liverpool Centre for Nutritional Genomics, Neuroendocrine and Obesity Biology Unit, Department of Medicine, University of Liverpool, University Clinical Departments, Duncan Building, Liverpool L69 3GA, UK
Biochem Biophys Res Commun 313:702-8. 2004..It is concluded that haptoglobin gene expression in adipocytes is stimulated by inflammatory cytokines, glucocorticoids, and the sympathetic system, while activation of the PPARgamma nuclear receptor is strongly inhibitory... - Resistin and RELM-alpha gene expression in white adipose tissue of lactating miceChen Bing
Neuroendocrine and Obesity Biology Unit, Department of Medicine, University of Liverpool, University Clinical Departments, Liverpool, UK
Biochem Biophys Res Commun 296:458-62. 2002.... - Acute and prolonged effects of TNF-alpha on the expression and secretion of inflammation-related adipokines by human adipocytes differentiated in cultureBohan Wang
Obesity Biology Unit, Liverpool Centre for Nutritional Genomics and Liverpool Obesity Research Network, School of Clinical Sciences, University of Liverpool, Liverpool L69 3GA, UK
Pflugers Arch 452:418-27. 2006..TNF-alpha has rapid and substantial effects on the synthesis of key inflammation-related adipokines in human adipocytes, with highly gene-specific responses... - Zinc-alpha2-glycoprotein, a lipid mobilizing factor, is expressed in adipocytes and is up-regulated in mice with cancer cachexiaChen Bing
Neuroendocrine and Obesity Biology Unit, Department of Medicine, University Clinical Departments, University of Liverpool, Liverpool L69 3GA, UK
Proc Natl Acad Sci U S A 101:2500-5. 2004..Overexpression in WAT of tumor-bearing mice suggests a local role for adipocyte-derived ZAG in the substantial reduction of adiposity of cancer cachexia... - Adipose tissue-derived adiponectin expression is significantly associated with increased post operative mortality in horses undergoing emergency abdominal surgeryM J Packer
School of Veterinary Science, Faculty of Health and Life Sciences, University of Liverpool, UK
Equine Vet J 43:26-33. 2011..Obesity is also an emerging welfare problem in the UK horse population, but the role that it plays in secondary diseases is unclear... - Weight loss in tumour-bearing mice is not associated with changes in resistin gene expression in white adipose tissueJ Gomez-Ambrosi
Neuroendocrine and Obesity Biology Unit, Department of Medicine, University of Liverpool, University Clinical Departments, UK
Horm Metab Res 34:674-7. 2002..Maintenance of resistin production may help inhibit the formation of new adipocytes in cancer cachexia... - Downregulation of zinc-{alpha}2-glycoprotein in adipose tissue and liver of obese ob/ob mice and by tumour necrosis factor-alpha in adipocytesT Mracek
Obesity Biology Research Unit, School of Clinical Sciences, University of Liverpool, Liverpool L69 3GA, UK
J Endocrinol 204:165-72. 2010..The reduced ZAG production may advance the susceptibility to lipid accumulation in these tissues in obesity, and this could be at least in part attributable to the inhibitory effect of TNFalpha... - Microarray analysis identifies matrix metalloproteinases (MMPs) as key genes whose expression is up-regulated in human adipocytes by macrophage-conditioned mediumAdrian O'Hara
Obesity Biology Research Unit, School of Clinical Sciences, University of Liverpool, Duncan Building, Liverpool, L69 3GA, UK
Pflugers Arch 458:1103-14. 2009..The induction of MMP1 and other MMPs suggests that macrophages stimulate tissue remodelling during adipose tissue expansion in obesity... - IL-33, a recently identified interleukin-1 gene family member, is expressed in human adipocytesI Stuart Wood
University Clinical Department, Obesity Biology Research Unit, School of Clinical Sciences, Royal Liverpool University Hospital, University of Liverpool, Liverpool, UK
Biochem Biophys Res Commun 384:105-9. 2009..Human adipocytes and preadipocytes express IL-33, but the various IL-1 family members exhibit major differences in responsiveness to TNFalpha... - Hypoxia stimulates lactate release and modulates monocarboxylate transporter (MCT1, MCT2, and MCT4) expression in human adipocytesFátima Pérez de Heredia
Obesity Biology Research Unit, School of Clinical Sciences, University of Liverpool, Duncan Building, Liverpool L69 3GA, UK
Pflugers Arch 459:509-18. 2010..Increased lactate production and monocarboxylate transporter expression are likely to be key components of the adaptive response of adipocytes to low O(2) tension as adipose tissue mass expands in obesity... - Cellular hypoxia and adipose tissue dysfunction in obesityI Stuart Wood
Obesity Biology Research Unit, School of Clinical Sciences, University of Liverpool, Duncan Building, Liverpool L69 3GA, UK
Proc Nutr Soc 68:370-7. 2009.... - New insights into adipose tissue atrophy in cancer cachexiaChen Bing
Obesity Biology Research Unit, School of Clinical Sciences, University of Liverpool, Liverpool L69 3GA, UK
Proc Nutr Soc 68:385-92. 2009..ZAG may therefore act locally, as well as systemically, to promote lipid mobilisation in cancer cachexia. Further elucidation of ZAG function in adipose tissue may lead to novel targets for preventing adipose atrophy in malignancy... - Adipokine expression and secretion by canine adipocytes: stimulation of inflammatory adipokine production by LPS and TNFalphaVivien H Ryan
Obesity Biology Research Unit, School of Clinical Sciences, University of Liverpool, Duncan Building, Liverpool, L69 3GA, UK
Pflugers Arch 460:603-16. 2010.... - Endotoxaemia leads to major increases in inflammatory adipokine gene expression in white adipose tissue of miceMartin Leuwer
Critical Care Research Unit, School of Clinical Sciences, University of Liverpool, University Clinical Departments, Duncan Building, Liverpool, L69 3GA, UK
Pflugers Arch 457:731-41. 2009..It is concluded that white adipose tissue may play an important role in the production of inflammatory mediators in endotoxaemia... - Glucose transporters (GLUT and SGLT): expanded families of sugar transport proteinsI Stuart Wood
Liverpool Centre for Nutritional Genomics, Neuroendocrine and Obesity Biology Unit, Department of Medicine, UK
Br J Nutr 89:3-9. 2003.... - Regulation of adipose tissue metabolism in cancer cachexiaChen Bing
Obesity Biology Unit, School of Clinical Sciences, University of Liverpool, Liverpool, UK
Curr Opin Clin Nutr Metab Care 11:201-7. 2008..This review presents recent studies focusing on the mechanisms of adipose atrophy in cancer cachexia, particularly the potential mediators... - Expression of Class III facilitative glucose transporter genes (GLUT-10 and GLUT-12) in mouse and human adipose tissuesI Stuart Wood
Liverpool Centre for Nutritional Genomics, Neuroendocrine and Obesity Biology Unit, Department of Medicine, University of Liverpool, Daulby Street, Liverpool L69 3GA, UK
Biochem Biophys Res Commun 308:43-9. 2003..Both GLUT-10 and GLUT-12 expression was also found in human adipose tissue (subcutaneous and omental) and SGBS adipocytes. It is concluded that white fat expresses a wide range of facilitative glucose transporters... - NGF gene expression and secretion in white adipose tissue: regulation in 3T3-L1 adipocytes by hormones and inflammatory cytokinesMuhammad R Peeraully
Neuroendocrine and Obesity Biology Unit, Liverpool Centre for Nutritional Genomics, School of Clinical Sciences, University of Liverpool, UK
Am J Physiol Endocrinol Metab 287:E331-9. 2004..We suggest that NGF is a target-derived neurotropin and an inflammatory response protein in white adipocytes... - The pro-inflammatory cytokine IL-18 is expressed in human adipose tissue and strongly upregulated by TNFalpha in human adipocytesI Stuart Wood
Obesity Biology Unit, Liverpool Centre for Nutritional Genomics, School of Clinical Sciences, University of Liverpool, University Clinical Departments, UK
Biochem Biophys Res Commun 337:422-9. 2005..IL-18 may be part of the inflammatory cascade within adipose tissue; however, human adipocytes do not appear to secrete significant amounts of IL-18... - Hypoxia increases expression of selective facilitative glucose transporters (GLUT) and 2-deoxy-D-glucose uptake in human adipocytesI Stuart Wood
Obesity Biology Unit, School of Clinical Sciences, University Clinical Departments, Royal Liverpool University Hospital, University of Liverpool, UK
Biochem Biophys Res Commun 361:468-73. 2007..4-fold) which was blocked by cytochalasin B. These results indicate that hypoxia increases monosaccharide uptake capacity in human adipocytes; this may contribute to adipose tissue dysregulation in obesity... - Hypoxia induces leptin gene expression and secretion in human preadipocytes: differential effects of hypoxia on adipokine expression by preadipocytesBohan Wang
Obesity Biology Research Unit, School of Clinical Sciences, University of Liverpool, Duncan Building, Liverpool L69 3GA, UK
J Endocrinol 198:127-34. 2008..Preadipocytes and adipocytes differ in their responsiveness to low O(2) tension, maturation of the response to hypoxia developing on differentiation... - Prostaglandin D2 and J2-series (PGJ2, Delta12-PGJ2) prostaglandins stimulate IL-6 and MCP-1, but inhibit leptin, expression and secretion by 3T3-L1 adipocytesMuhammad R Peeraully
Obesity Biology Unit, Liverpool Centre for Nutritional Genomics and Liverpool Obesity Research Network, Division of Metabolic and Cellular Medicine, University of Liverpool, Duncan Building, Liverpool, UK
Pflugers Arch 453:177-87. 2006..Such effects could be important in the inflammatory response in adipose tissue... - Identification of macrophage inhibitory cytokine-1 in adipose tissue and its secretion as an adipokine by human adipocytesQi Ding
Obesity Biology Research Unit, School of Clinical Sciences, University of Liverpool, Liverpool, United Kingdom
Endocrinology 150:1688-96. 2009..We conclude that MIC-1 is expressed in adipose tissue and secreted from adipocytes and is therefore a new adipokine. MIC-1 may have a paracrine role in the modulation of adipose tissue function and body fat mass... - Regulation of angiopoietin-like protein 4/fasting-induced adipose factor (Angptl4/FIAF) expression in mouse white adipose tissue and 3T3-L1 adipocytesSarah Dutton
Obesity Biology Unit, Liverpool Obesity Research Network, School of Clinical Sciences, University of Liverpool, Duncan Building, Liverpool L69 3GA, UK
Br J Nutr 100:18-26. 2008..Angptl4/FIAF does not act as an adipose tissue signal of nutritional status, but is markedly induced by fasting in liver and skeletal muscle... - Stimulation of NGF expression and secretion in 3T3-L1 adipocytes by prostaglandins PGD2, PGJ2, and Delta12-PGJ2Monica Bullo
Neuroendocrine and Obesity Biology Unit, Liverpool Centre for Nutritional Genomics, School of Clinical Sciences, University of Liverpool, UCD Bldg, Liverpool L69 3GA, UK
Am J Physiol Endocrinol Metab 289:E62-7. 2005..These results provide support for the view that NGF is an important inflammatory response protein, as well as a target-derived neurotrophin, in white adipose tissue... - Obesity, its associated disorders and the role of inflammatory adipokines in companion animalsAlexander J German
School of Veterinary Science, University of Liverpool, Leahurst Campus, Neston, Wirral CH64 7TE, UK
Vet J 185:4-9. 2010.... - Postnatal expression of zinc-alpha2-glycoprotein in rat white and brown adipose tissueTheodora Tzanavari
Obesity Biology Unit, Division of Metabolic and Cellular Medicine, School of Clinical Sciences, University of Liverpool, Liverpool L69 3GA, UK
Mol Cell Endocrinol 279:26-33. 2007..The downregulated ZAG expression in white fat depots at weaning, when fat mass is expanded substantially, suggests that ZAG might be involved in the postnatal development of adipose tissue mass... - Comment on: Hosagai et al. (2007) Adipose tissue hypoxia in obesity and its impact on adipocytokine dysregulation: Diabetes 56:901-911Paul Trayhurn
Diabetes 56:e14. 2007 - Inflammatory gene expression patterns revealed by DNA microarray analysis in TNF-alpha-treated SGBS human adipocytesMyoung Sool Do
School of Life and Food Sciences, Handong Global University Pohang, Korea
Yonsei Med J 47:729-36. 2006..Further investigation into the role of these up- or down-regulated cytokine genes during the pathological processes leading to the development of atherosclerosis is warranted... - The public library of science and "open access" to the scientific literaturePaul Trayhurn
Br J Nutr 87:1-2. 2002 - Circulating nerve growth factor levels in relation to obesity and the metabolic syndrome in womenMonica Bullo
Unitat de Nutricio Humana, Facultat de Medicina i Ciencies de la Salut de Reus, Universitat Rovira i Virgili, 43201, Reus, Spain
Eur J Endocrinol 157:303-10. 2007..This is the first study evaluating the plasma NT levels in a group of women with obesity and MetSyn, and also the adipose tissue nerve growth factor (NGF) expression in a small group of them... - Obesity -- what role now for nutritional science?Paul Trayhurn
Br J Nutr 93:1-2. 2005 - Ontogenic loss of brown adipose tissue sensitivity to beta-adrenergic stimulation in the ovineMichael A Lomax
Division of Biomedical Science, Imperial College, Ashford, Kent TN25 5AH, UK
Endocrinology 148:461-8. 2007..These data are consistent with a model in which postnatal loss of UCP1 expression and beta-adrenergic induction of the brown adipocyte phenotype is due to loss of expression of PGC-1alpha and PPARalpha... - White adipose tissue grafts--keeping in contactPaul Trayhurn
Am J Physiol Regul Integr Comp Physiol 289:R297-R298. 2005