P Trayhurn

Summary

Affiliation: University of Liverpool
Country: UK

Publications

  1. ncbi request reprint Expression and secretion of inflammation-related adipokines by human adipocytes differentiated in culture: integrated response to TNF-alpha
    Bohan Wang
    Neuroendocrine and Obesity Biology Unit, School of Clinical Sciences, University of Liverpool, Liverpool, UK
    Am J Physiol Endocrinol Metab 288:E731-40. 2005
  2. pmc Dysregulation of the expression and secretion of inflammation-related adipokines by hypoxia in human adipocytes
    Bohan Wang
    Obesity Biology Unit Liverpool Centre for Nutritional Genomics and Liverpool Obesity Research Network, School of Clinical Sciences, University Clinical Departments, University of Liverpool, Liverpool, UK
    Pflugers Arch 455:479-92. 2007
  3. pmc PCR arrays identify metallothionein-3 as a highly hypoxia-inducible gene in human adipocytes
    Bohan Wang
    Obesity Biology Unit, School of Clinical Sciences, University of Liverpool, Duncan Building, Liverpool L69 3GA, UK
    Biochem Biophys Res Commun 368:88-93. 2008
  4. ncbi request reprint Adipose tissue in obesity--an inflammatory issue
    Paul Trayhurn
    Neuroendocrinology and Obesity Biology Unit, Liverpool Centre for Nutritional Genomics, Division of Metabolic and Cellular Medicine, School of Clinical Sciences, University of Liverpool, Liverpool L69 3GA, United Kingdom
    Endocrinology 146:1003-5. 2005
  5. ncbi request reprint The biology of obesity
    Paul Trayhurn
    Neuroendocrine and Obesity Biology Unit, Liverpool Centre for Nutritional Genomics, School of Clinical Sciences, University of Liverpool, UK
    Proc Nutr Soc 64:31-8. 2005
  6. doi request reprint Hypoxia in adipose tissue: a basis for the dysregulation of tissue function in obesity?
    Paul Trayhurn
    Obesity Biology Unit, School of Clinical Sciences, University of Liverpool, University Clinical Department, Duncan Building, Liverpool L69 3GA, UK
    Br J Nutr 100:227-35. 2008
  7. ncbi request reprint Endocrine and signalling role of adipose tissue: new perspectives on fat
    P Trayhurn
    Neuroendocrine and Obesity Biology Unit, Liverpool Centre for Nutritional Genomics, School of Clinical Sciences, University of Liverpool, Liverpool, UK
    Acta Physiol Scand 184:285-93. 2005
  8. ncbi request reprint Signalling role of adipose tissue: adipokines and inflammation in obesity
    P Trayhurn
    Obesity Biology Unit, Liverpool Centre for Nutritional Genomics, School of Clinical Sciences, University of Liverpool, Duncan Building, Liverpool L69 3GA, UK
    Biochem Soc Trans 33:1078-81. 2005
  9. ncbi request reprint Adipose tissue and adipokines--energy regulation from the human perspective
    Paul Trayhurn
    Obesity Biology Unit, School of Clinical Sciences, University of Liverpool, Liverpool L69 3GA, UK
    J Nutr 136:1935S-1939S. 2006
  10. pmc Appetite and energy balance signals from adipocytes
    Paul Trayhurn
    Obesity Biology Unit Liverpool Centre for Nutritional Genomics and Liverpool Obesity Research Network, School of Clinical Sciences, University of Liverpool, UK
    Philos Trans R Soc Lond B Biol Sci 361:1237-49. 2006

Collaborators

Detail Information

Publications61

  1. ncbi request reprint Expression and secretion of inflammation-related adipokines by human adipocytes differentiated in culture: integrated response to TNF-alpha
    Bohan Wang
    Neuroendocrine and Obesity Biology Unit, School of Clinical Sciences, University of Liverpool, Liverpool, UK
    Am J Physiol Endocrinol Metab 288:E731-40. 2005
    ....
  2. pmc Dysregulation of the expression and secretion of inflammation-related adipokines by hypoxia in human adipocytes
    Bohan Wang
    Obesity Biology Unit Liverpool Centre for Nutritional Genomics and Liverpool Obesity Research Network, School of Clinical Sciences, University Clinical Departments, University of Liverpool, Liverpool, UK
    Pflugers Arch 455:479-92. 2007
    ..Hypoxia may underlie the development of the inflammatory response in adipocytes, leading to obesity-associated diseases...
  3. pmc PCR arrays identify metallothionein-3 as a highly hypoxia-inducible gene in human adipocytes
    Bohan Wang
    Obesity Biology Unit, School of Clinical Sciences, University of Liverpool, Duncan Building, Liverpool L69 3GA, UK
    Biochem Biophys Res Commun 368:88-93. 2008
    ..MT-3 is a highly hypoxia-inducible gene in human adipocytes; the protein may protect adipocytes from hypoxic damage...
  4. ncbi request reprint Adipose tissue in obesity--an inflammatory issue
    Paul Trayhurn
    Neuroendocrinology and Obesity Biology Unit, Liverpool Centre for Nutritional Genomics, Division of Metabolic and Cellular Medicine, School of Clinical Sciences, University of Liverpool, Liverpool L69 3GA, United Kingdom
    Endocrinology 146:1003-5. 2005
  5. ncbi request reprint The biology of obesity
    Paul Trayhurn
    Neuroendocrine and Obesity Biology Unit, Liverpool Centre for Nutritional Genomics, School of Clinical Sciences, University of Liverpool, UK
    Proc Nutr Soc 64:31-8. 2005
    ..It has been suggested that inflammation in obesity is principally an adaptive response to hypoxia in clusters of adipocytes within the expanding adipose mass...
  6. doi request reprint Hypoxia in adipose tissue: a basis for the dysregulation of tissue function in obesity?
    Paul Trayhurn
    Obesity Biology Unit, School of Clinical Sciences, University of Liverpool, University Clinical Department, Duncan Building, Liverpool L69 3GA, UK
    Br J Nutr 100:227-35. 2008
    ....
  7. ncbi request reprint Endocrine and signalling role of adipose tissue: new perspectives on fat
    P Trayhurn
    Neuroendocrine and Obesity Biology Unit, Liverpool Centre for Nutritional Genomics, School of Clinical Sciences, University of Liverpool, Liverpool, UK
    Acta Physiol Scand 184:285-93. 2005
    ....
  8. ncbi request reprint Signalling role of adipose tissue: adipokines and inflammation in obesity
    P Trayhurn
    Obesity Biology Unit, Liverpool Centre for Nutritional Genomics, School of Clinical Sciences, University of Liverpool, Duncan Building, Liverpool L69 3GA, UK
    Biochem Soc Trans 33:1078-81. 2005
    ..WAT is involved in extensive cross-talk with other organs and multiple metabolic systems through the various adipokines...
  9. ncbi request reprint Adipose tissue and adipokines--energy regulation from the human perspective
    Paul Trayhurn
    Obesity Biology Unit, School of Clinical Sciences, University of Liverpool, Liverpool L69 3GA, UK
    J Nutr 136:1935S-1939S. 2006
    ..Although the focus remains very much on obesity in humans, the disorder and its sequelae are also a growing concern in companion animals...
  10. pmc Appetite and energy balance signals from adipocytes
    Paul Trayhurn
    Obesity Biology Unit Liverpool Centre for Nutritional Genomics and Liverpool Obesity Research Network, School of Clinical Sciences, University of Liverpool, UK
    Philos Trans R Soc Lond B Biol Sci 361:1237-49. 2006
    ..Through leptin and the other adipokines it is evident that adipose tissue communicates extensively with other organs and plays a pervasive role in metabolic homeostasis...
  11. ncbi request reprint Adipocyte biology
    P Trayhurn
    Obesity Biology Unit, School of Clinical Sciences, University of Liverpool, Liverpool, UK
    Obes Rev 8:41-4. 2007
  12. ncbi request reprint Hypoxia and the endocrine and signalling role of white adipose tissue
    Paul Trayhurn
    Obesity Biology Research Unit, School of Clinical Sciences, University of Liverpool, University Clinical Departments, Liverpool, UK
    Arch Physiol Biochem 114:267-76. 2008
    ..Hypoxia also stimulates glucose transport by adipocytes and may have a pervasive effect on cell function within adipose tissue...
  13. ncbi request reprint Adipokines: inflammation and the pleiotropic role of white adipose tissue
    Paul Trayhurn
    Neuroendocrine and Obesity Biology Unit, Liverpool Centre for Nutritional Genomics, School of Clinical Sciences, University of Liverpool, UK
    Br J Nutr 92:347-55. 2004
    ....
  14. ncbi request reprint Leptin--a critical body weight signal and a "master" hormone?
    Paul Trayhurn
    Liverpool Centre for Nutritional Genomics, Neuroendocrine and Obesity Biology Unit, Department of Medicine, University of Liverpool, University Clinical Departments, Liverpool L69 3GA, UK
    Sci STKE 2003:PE7. 2003
    ....
  15. doi request reprint Secreted proteins from adipose tissue and skeletal muscle - adipokines, myokines and adipose/muscle cross-talk
    Paul Trayhurn
    Obesity Biology Unit, Institute of Ageing and Chronic Diseases, University of Liverpool, UK
    Arch Physiol Biochem 117:47-56. 2011
    ..For example, IL-6, secreted from myocytes may stimulate lipolysis in adipose tissue, while adipocyte-derived IL-6 may induce insulin resistance in muscle...
  16. doi request reprint Macrophage-secreted factors inhibit ZAG expression and secretion by human adipocytes
    D Gao
    Obesity Biology Research Unit, School of Clinical Sciences, University of Liverpool, Liverpool L69 3GA, UK
    Mol Cell Endocrinol 325:135-42. 2010
    ..These findings suggest that macrophage-associated inflammation may play a significant role in the downregulation of ZAG in adipose tissue in obesity...
  17. doi request reprint The adipokine zinc-alpha2-glycoprotein (ZAG) is downregulated with fat mass expansion in obesity
    T Mracek
    Obesity Biology Research Unit, School of Clinical Sciences, University of Liverpool, Liverpool, UK
    Clin Endocrinol (Oxf) 72:334-41. 2010
    ..The study also examined the association between ZAG and adiponectin expression in human adipose tissue, and whether ZAG modulates adiponectin secretion by human adipocytes...
  18. doi request reprint 11-Hydroxy-β-steroid dehydrogenase gene expression in canine adipose tissue and adipocytes: stimulation by lipopolysaccharide and tumor necrosis factor α
    V H Ryan
    Department of Obesity and Endocrinology, School of Veterinary Science, University of Liverpool, Liverpool L69 3GA, United Kingdom
    Domest Anim Endocrinol 41:150-61. 2011
    ..The induction of 11β-HSD-1 expression, by the pro-inflammatory cytokine tumor necrosis factor α and by lipopolysaccharide may have implications for the pathogenesis of obesity and its associated diseases in the dog...
  19. pmc Enhanced ZAG production by subcutaneous adipose tissue is linked to weight loss in gastrointestinal cancer patients
    T Mracek
    Obesity Biology Research Unit, School of Clinical Sciences, University of Liverpool, Liverpool L69 3GA, UK
    Br J Cancer 104:441-7. 2011
    ..Profound loss of adipose tissue is a hallmark of cancer cachexia. Zinc-α2-glycoprotein (ZAG), a recently identified adipokine, is suggested as a candidate in lipid catabolism...
  20. doi request reprint Improvement in insulin resistance and reduction in plasma inflammatory adipokines after weight loss in obese dogs
    A J German
    Department of Veterinary Clinical Sciences, University of Liverpool, Neston, Wirral, United Kingdom
    Domest Anim Endocrinol 37:214-26. 2009
    ..Concurrent decreases in TNF-alpha and adipose tissue mass suggest that in dogs, as in humans, this adipokine may be implicated in the insulin resistance of obesity...
  21. pmc Adipose atrophy in cancer cachexia: morphologic and molecular analysis of adipose tissue in tumour-bearing mice
    C Bing
    Obesity Biology Unit, Division of Metabolic and Cellular Medicine, School of Clinical Sciences, University of Liverpool, Liverpool L69 3GA, UK
    Br J Cancer 95:1028-37. 2006
    ..These results suggest that the tumour-induced impairment in the formation and lipid storing capacity of adipose tissue occurs in mice with cancer cachexia...
  22. doi request reprint Zinc-α2-glycoprotein: an adipokine modulator of body fat mass?
    C Bing
    Obesity Biology Research Unit, School of Clinical Sciences, University of Liverpool, Liverpool, UK
    Int J Obes (Lond) 34:1559-65. 2010
    ..The present review summarizes these new perspectives of ZAG and the potential mechanisms by which it might modulate adipose tissue mass and function...
  23. doi request reprint NGF gene expression and secretion by canine adipocytes in primary culture: upregulation by the inflammatory mediators LPS and TNFalpha
    V H Ryan
    School of Clinical Sciences, University of Liverpool, Liverpool, UK
    Horm Metab Res 40:861-8. 2008
    ..Canine adipocytes appear highly sensitive to inflammatory stimuli...
  24. ncbi request reprint Zinc-alpha2-glycoprotein, a lipid mobilizing factor, is expressed and secreted by human (SGBS) adipocytes
    Yi Bao
    Neuroendocrine and Obesity Biology Unit, School of Clinical Sciences, University Clinical Departments, University of Liverpool, Liverpool L69 3GA, UK
    FEBS Lett 579:41-7. 2005
    ..ZAG is a novel adipokine, which may be involved in the local regulation of adipose tissue function...
  25. ncbi request reprint Adipokine gene expression in dog adipose tissues and dog white adipocytes differentiated in primary culture
    I Eisele
    Neuroendocrine and Obesity Biology Unit, Liverpool Centre for Nutritional Genomics, School of Clinical Sciences, University of Liverpool, University Clinical Departments, Liverpool L69 3GA, United Kingdom
    Horm Metab Res 37:474-81. 2005
    ..Investigation of adipokine production and function will provide insight into the mechanisms involved in obesity-related pathologies in dogs and serve as a model for the related human diseases...
  26. doi request reprint Upregulation of the expression of inflammatory and angiogenic markers in human adipocytes by a synthetic cannabinoid, JTE-907
    P González-Muniesa
    Obesity Biology Research Unit, School of Clinical Sciences, University of Liverpool, UCD, Duncan Building, Liverpool, UK
    Horm Metab Res 42:710-7. 2010
    ..CB1 and TRPV1 receptors participate in the regulation of several inflammatory and angiogenic factors in human adipocytes, indicating their potential value as targets for the treatment of disorders related to obesity...
  27. pmc Zinc-alpha2-glycoprotein, a lipid mobilizing factor, is expressed in adipocytes and is up-regulated in mice with cancer cachexia
    Chen Bing
    Neuroendocrine and Obesity Biology Unit, Department of Medicine, University Clinical Departments, University of Liverpool, Liverpool L69 3GA, UK
    Proc Natl Acad Sci U S A 101:2500-5. 2004
    ..Overexpression in WAT of tumor-bearing mice suggests a local role for adipocyte-derived ZAG in the substantial reduction of adiposity of cancer cachexia...
  28. ncbi request reprint Resistin and RELM-alpha gene expression in white adipose tissue of lactating mice
    Chen Bing
    Neuroendocrine and Obesity Biology Unit, Department of Medicine, University of Liverpool, University Clinical Departments, Liverpool, UK
    Biochem Biophys Res Commun 296:458-62. 2002
    ....
  29. ncbi request reprint Regulation of haptoglobin gene expression in 3T3-L1 adipocytes by cytokines, catecholamines, and PPARgamma
    Claudia Oller do Nascimento
    Liverpool Centre for Nutritional Genomics, Neuroendocrine and Obesity Biology Unit, Department of Medicine, University of Liverpool, University Clinical Departments, Duncan Building, Liverpool L69 3GA, UK
    Biochem Biophys Res Commun 313:702-8. 2004
    ..It is concluded that haptoglobin gene expression in adipocytes is stimulated by inflammatory cytokines, glucocorticoids, and the sympathetic system, while activation of the PPARgamma nuclear receptor is strongly inhibitory...
  30. ncbi request reprint Acute and prolonged effects of TNF-alpha on the expression and secretion of inflammation-related adipokines by human adipocytes differentiated in culture
    Bohan Wang
    Obesity Biology Unit, Liverpool Centre for Nutritional Genomics and Liverpool Obesity Research Network, School of Clinical Sciences, University of Liverpool, Liverpool L69 3GA, UK
    Pflugers Arch 452:418-27. 2006
    ..TNF-alpha has rapid and substantial effects on the synthesis of key inflammation-related adipokines in human adipocytes, with highly gene-specific responses...
  31. doi request reprint Adipose tissue-derived adiponectin expression is significantly associated with increased post operative mortality in horses undergoing emergency abdominal surgery
    M J Packer
    School of Veterinary Science, Faculty of Health and Life Sciences, University of Liverpool, UK
    Equine Vet J 43:26-33. 2011
    ..Obesity is also an emerging welfare problem in the UK horse population, but the role that it plays in secondary diseases is unclear...
  32. ncbi request reprint Weight loss in tumour-bearing mice is not associated with changes in resistin gene expression in white adipose tissue
    J Gomez-Ambrosi
    Neuroendocrine and Obesity Biology Unit, Department of Medicine, University of Liverpool, University Clinical Departments, UK
    Horm Metab Res 34:674-7. 2002
    ..Maintenance of resistin production may help inhibit the formation of new adipocytes in cancer cachexia...
  33. pmc Downregulation of zinc-{alpha}2-glycoprotein in adipose tissue and liver of obese ob/ob mice and by tumour necrosis factor-alpha in adipocytes
    T Mracek
    Obesity Biology Research Unit, School of Clinical Sciences, University of Liverpool, Liverpool L69 3GA, UK
    J Endocrinol 204:165-72. 2010
    ..The reduced ZAG production may advance the susceptibility to lipid accumulation in these tissues in obesity, and this could be at least in part attributable to the inhibitory effect of TNFalpha...
  34. pmc Hypoxia increases expression of selective facilitative glucose transporters (GLUT) and 2-deoxy-D-glucose uptake in human adipocytes
    I Stuart Wood
    Obesity Biology Unit, School of Clinical Sciences, University Clinical Departments, Royal Liverpool University Hospital, University of Liverpool, UK
    Biochem Biophys Res Commun 361:468-73. 2007
    ..4-fold) which was blocked by cytochalasin B. These results indicate that hypoxia increases monosaccharide uptake capacity in human adipocytes; this may contribute to adipose tissue dysregulation in obesity...
  35. doi request reprint Microarray analysis identifies matrix metalloproteinases (MMPs) as key genes whose expression is up-regulated in human adipocytes by macrophage-conditioned medium
    Adrian O'Hara
    Obesity Biology Research Unit, School of Clinical Sciences, University of Liverpool, Duncan Building, Liverpool, L69 3GA, UK
    Pflugers Arch 458:1103-14. 2009
    ..The induction of MMP1 and other MMPs suggests that macrophages stimulate tissue remodelling during adipose tissue expansion in obesity...
  36. ncbi request reprint NGF gene expression and secretion in white adipose tissue: regulation in 3T3-L1 adipocytes by hormones and inflammatory cytokines
    Muhammad R Peeraully
    Neuroendocrine and Obesity Biology Unit, Liverpool Centre for Nutritional Genomics, School of Clinical Sciences, University of Liverpool, UK
    Am J Physiol Endocrinol Metab 287:E331-9. 2004
    ..We suggest that NGF is a target-derived neurotropin and an inflammatory response protein in white adipocytes...
  37. doi request reprint Cellular hypoxia and adipose tissue dysfunction in obesity
    I Stuart Wood
    Obesity Biology Research Unit, School of Clinical Sciences, University of Liverpool, Duncan Building, Liverpool L69 3GA, UK
    Proc Nutr Soc 68:370-7. 2009
    ....
  38. doi request reprint New insights into adipose tissue atrophy in cancer cachexia
    Chen Bing
    Obesity Biology Research Unit, School of Clinical Sciences, University of Liverpool, Liverpool L69 3GA, UK
    Proc Nutr Soc 68:385-92. 2009
    ..ZAG may therefore act locally, as well as systemically, to promote lipid mobilisation in cancer cachexia. Further elucidation of ZAG function in adipose tissue may lead to novel targets for preventing adipose atrophy in malignancy...
  39. doi request reprint Hypoxia stimulates lactate release and modulates monocarboxylate transporter (MCT1, MCT2, and MCT4) expression in human adipocytes
    Fátima Pérez de Heredia
    Obesity Biology Research Unit, School of Clinical Sciences, University of Liverpool, Duncan Building, Liverpool L69 3GA, UK
    Pflugers Arch 459:509-18. 2010
    ..Increased lactate production and monocarboxylate transporter expression are likely to be key components of the adaptive response of adipocytes to low O(2) tension as adipose tissue mass expands in obesity...
  40. doi request reprint Adipokine expression and secretion by canine adipocytes: stimulation of inflammatory adipokine production by LPS and TNFalpha
    Vivien H Ryan
    Obesity Biology Research Unit, School of Clinical Sciences, University of Liverpool, Duncan Building, Liverpool, L69 3GA, UK
    Pflugers Arch 460:603-16. 2010
    ....
  41. doi request reprint IL-33, a recently identified interleukin-1 gene family member, is expressed in human adipocytes
    I Stuart Wood
    University Clinical Department, Obesity Biology Research Unit, School of Clinical Sciences, Royal Liverpool University Hospital, University of Liverpool, Liverpool, UK
    Biochem Biophys Res Commun 384:105-9. 2009
    ..Human adipocytes and preadipocytes express IL-33, but the various IL-1 family members exhibit major differences in responsiveness to TNFalpha...
  42. ncbi request reprint The pro-inflammatory cytokine IL-18 is expressed in human adipose tissue and strongly upregulated by TNFalpha in human adipocytes
    I Stuart Wood
    Obesity Biology Unit, Liverpool Centre for Nutritional Genomics, School of Clinical Sciences, University of Liverpool, University Clinical Departments, UK
    Biochem Biophys Res Commun 337:422-9. 2005
    ..IL-18 may be part of the inflammatory cascade within adipose tissue; however, human adipocytes do not appear to secrete significant amounts of IL-18...
  43. ncbi request reprint Glucose transporters (GLUT and SGLT): expanded families of sugar transport proteins
    I Stuart Wood
    Liverpool Centre for Nutritional Genomics, Neuroendocrine and Obesity Biology Unit, Department of Medicine, UK
    Br J Nutr 89:3-9. 2003
    ....
  44. ncbi request reprint Expression of Class III facilitative glucose transporter genes (GLUT-10 and GLUT-12) in mouse and human adipose tissues
    I Stuart Wood
    Liverpool Centre for Nutritional Genomics, Neuroendocrine and Obesity Biology Unit, Department of Medicine, University of Liverpool, Daulby Street, Liverpool L69 3GA, UK
    Biochem Biophys Res Commun 308:43-9. 2003
    ..Both GLUT-10 and GLUT-12 expression was also found in human adipose tissue (subcutaneous and omental) and SGBS adipocytes. It is concluded that white fat expresses a wide range of facilitative glucose transporters...
  45. doi request reprint Endotoxaemia leads to major increases in inflammatory adipokine gene expression in white adipose tissue of mice
    Martin Leuwer
    Critical Care Research Unit, School of Clinical Sciences, University of Liverpool, University Clinical Departments, Duncan Building, Liverpool, L69 3GA, UK
    Pflugers Arch 457:731-41. 2009
    ..It is concluded that white adipose tissue may play an important role in the production of inflammatory mediators in endotoxaemia...
  46. doi request reprint Regulation of adipose tissue metabolism in cancer cachexia
    Chen Bing
    Obesity Biology Unit, School of Clinical Sciences, University of Liverpool, Liverpool, UK
    Curr Opin Clin Nutr Metab Care 11:201-7. 2008
    ..This review presents recent studies focusing on the mechanisms of adipose atrophy in cancer cachexia, particularly the potential mediators...
  47. doi request reprint Hypoxia induces leptin gene expression and secretion in human preadipocytes: differential effects of hypoxia on adipokine expression by preadipocytes
    Bohan Wang
    Obesity Biology Research Unit, School of Clinical Sciences, University of Liverpool, Duncan Building, Liverpool L69 3GA, UK
    J Endocrinol 198:127-34. 2008
    ..Preadipocytes and adipocytes differ in their responsiveness to low O(2) tension, maturation of the response to hypoxia developing on differentiation...
  48. pmc 1,25-Dihydroxyvitamin D3 inhibits the cytokine-induced secretion of MCP-1 and reduces monocyte recruitment by human preadipocytes
    D Gao
    Obesity Biology Research Unit, Department of Obesity and Endocrinology, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, UK
    Int J Obes (Lond) 37:357-65. 2013
    ..Preadipocytes, one of the major cell types in adipose tissue, are actively involved in inflammatory processes...
  49. ncbi request reprint Regulation of angiopoietin-like protein 4/fasting-induced adipose factor (Angptl4/FIAF) expression in mouse white adipose tissue and 3T3-L1 adipocytes
    Sarah Dutton
    Obesity Biology Unit, Liverpool Obesity Research Network, School of Clinical Sciences, University of Liverpool, Duncan Building, Liverpool L69 3GA, UK
    Br J Nutr 100:18-26. 2008
    ..Angptl4/FIAF does not act as an adipose tissue signal of nutritional status, but is markedly induced by fasting in liver and skeletal muscle...
  50. doi request reprint Identification of macrophage inhibitory cytokine-1 in adipose tissue and its secretion as an adipokine by human adipocytes
    Qi Ding
    Obesity Biology Research Unit, School of Clinical Sciences, University of Liverpool, Liverpool, United Kingdom
    Endocrinology 150:1688-96. 2009
    ..We conclude that MIC-1 is expressed in adipose tissue and secreted from adipocytes and is therefore a new adipokine. MIC-1 may have a paracrine role in the modulation of adipose tissue function and body fat mass...
  51. ncbi request reprint Prostaglandin D2 and J2-series (PGJ2, Delta12-PGJ2) prostaglandins stimulate IL-6 and MCP-1, but inhibit leptin, expression and secretion by 3T3-L1 adipocytes
    Muhammad R Peeraully
    Obesity Biology Unit, Liverpool Centre for Nutritional Genomics and Liverpool Obesity Research Network, Division of Metabolic and Cellular Medicine, University of Liverpool, Duncan Building, Liverpool, UK
    Pflugers Arch 453:177-87. 2006
    ..Such effects could be important in the inflammatory response in adipose tissue...
  52. ncbi request reprint Postnatal expression of zinc-alpha2-glycoprotein in rat white and brown adipose tissue
    Theodora Tzanavari
    Obesity Biology Unit, Division of Metabolic and Cellular Medicine, School of Clinical Sciences, University of Liverpool, Liverpool L69 3GA, UK
    Mol Cell Endocrinol 279:26-33. 2007
    ..The downregulated ZAG expression in white fat depots at weaning, when fat mass is expanded substantially, suggests that ZAG might be involved in the postnatal development of adipose tissue mass...
  53. doi request reprint Obesity, its associated disorders and the role of inflammatory adipokines in companion animals
    Alexander J German
    School of Veterinary Science, University of Liverpool, Leahurst Campus, Neston, Wirral CH64 7TE, UK
    Vet J 185:4-9. 2010
    ....
  54. ncbi request reprint Stimulation of NGF expression and secretion in 3T3-L1 adipocytes by prostaglandins PGD2, PGJ2, and Delta12-PGJ2
    Monica Bullo
    Neuroendocrine and Obesity Biology Unit, Liverpool Centre for Nutritional Genomics, School of Clinical Sciences, University of Liverpool, UCD Bldg, Liverpool L69 3GA, UK
    Am J Physiol Endocrinol Metab 289:E62-7. 2005
    ..These results provide support for the view that NGF is an important inflammatory response protein, as well as a target-derived neurotrophin, in white adipose tissue...
  55. pmc Inflammatory gene expression patterns revealed by DNA microarray analysis in TNF-alpha-treated SGBS human adipocytes
    Myoung Sool Do
    School of Life and Food Sciences, Handong Global University Pohang, Korea
    Yonsei Med J 47:729-36. 2006
    ..Further investigation into the role of these up- or down-regulated cytokine genes during the pathological processes leading to the development of atherosclerosis is warranted...
  56. ncbi request reprint Comment on: Hosagai et al. (2007) Adipose tissue hypoxia in obesity and its impact on adipocytokine dysregulation: Diabetes 56:901-911
    Paul Trayhurn
    Diabetes 56:e14. 2007
  57. ncbi request reprint The public library of science and "open access" to the scientific literature
    Paul Trayhurn
    Br J Nutr 87:1-2. 2002
  58. ncbi request reprint White adipose tissue grafts--keeping in contact
    Paul Trayhurn
    Am J Physiol Regul Integr Comp Physiol 289:R297-R298. 2005
  59. ncbi request reprint Circulating nerve growth factor levels in relation to obesity and the metabolic syndrome in women
    Monica Bullo
    Unitat de Nutricio Humana, Facultat de Medicina i Ciencies de la Salut de Reus, Universitat Rovira i Virgili, 43201, Reus, Spain
    Eur J Endocrinol 157:303-10. 2007
    ..This is the first study evaluating the plasma NT levels in a group of women with obesity and MetSyn, and also the adipose tissue nerve growth factor (NGF) expression in a small group of them...
  60. ncbi request reprint Ontogenic loss of brown adipose tissue sensitivity to beta-adrenergic stimulation in the ovine
    Michael A Lomax
    Division of Biomedical Science, Imperial College, Ashford, Kent TN25 5AH, UK
    Endocrinology 148:461-8. 2007
    ..These data are consistent with a model in which postnatal loss of UCP1 expression and beta-adrenergic induction of the brown adipocyte phenotype is due to loss of expression of PGC-1alpha and PPARalpha...
  61. ncbi request reprint Obesity -- what role now for nutritional science?
    Paul Trayhurn
    Br J Nutr 93:1-2. 2005