Research Topics
Species | Irene TraceySummaryAffiliation: University of Oxford Country: UK Publications
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Publications
How neuroimaging studies have challenged us to rethink: is chronic pain a disease?Irene Tracey
Oxford Centre for Functional Magnetic Resonance Imaging of the Brain, Nuffield Department of Anaesthetics, University of Oxford, John Radcliffe Hospital, Headington, England, UK
J Pain 10:1113-20. 2009..This review examines the information from these functional, structural, and molecular studies within the framework of a disease state...- Neuroimaging of pain mechanismsIrene Tracey
Centre for Functional Magnetic Resonance Imaging of the Brain, Departments of Clinical Neurology and Nuffield Department of Anaesthetics, Oxford University, Oxford, UK
Curr Opin Support Palliat Care 1:109-16. 2007..It is timely, therefore, to review the advances in neuroimaging applications to pain... 
Imaging attentional modulation of pain in the periaqueductal gray in humansIrene Tracey
Centre for Functional Magnetic Resonance Imaging of the Brain, Department of Clinical Neurology, University of Oxford, Oxford OX3 9DU, United Kingdom
J Neurosci 22:2748-52. 2002..This provides direct evidence supporting the notion that the periaqueductal gray is a site for higher cortical control of pain modulation in humans...- The cerebral signature for pain perception and its modulationIrene Tracey
Centre for Functional Magnetic Resonance Imaging of the Brain, Clinical Neurology and Nuffield Department of Anaesthetics, Oxford University, OX3 9DU Oxford, England, UK
Neuron 55:377-91. 2007.... - Imaging painI Tracey
Centre for Functional Magnetic Resonance Imaging of the Brain, Department of Clinical Neurology, Oxford University, John Radcliffe Hospital, Headington, Oxford, UK
Br J Anaesth 101:32-9. 2008..In this review, I shall briefly summarize our current state of knowledge regarding the central representation of pain perception in varying situations... - Can neuroimaging studies identify pain endophenotypes in humans?Irene Tracey
Oxford Center for Functional Magnetic Resonance Imaging of the Brain, Nuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK
Nat Rev Neurol 7:173-81. 2011..This endophenotypic approach-the focus of this Review-simplifies the connection between genes and behavior and is needed for complex disorders like chronic pain... - Getting the pain you expect: mechanisms of placebo, nocebo and reappraisal effects in humansIrene Tracey
Nuffield Department of Anaesthetics and Oxford Centre for Functional Magnetic Resonance Imaging of the Brain, Department of Clinical Neurology, University of Oxford, Oxford, UK
Nat Med 16:1277-83. 2010..The findings have relevance for chronic pain states and other disorders, where abnormal functioning of crucial brain regions might affect analgesic outcome even in the normal therapeutic setting... - Cortical and subcortical connectivity changes during decreasing levels of consciousness in humans: a functional magnetic resonance imaging study using propofolRoisin Ni Mhuircheartaigh
Centre for Functional Magnetic Resonance of the Brain FMRIB, Department of Clinical Neurology and Nuffield Department of Anaesthetics, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom
J Neurosci 30:9095-102. 2010..This result has not been previously described and suggests that disruption of subcortical thalamo-regulatory systems may occur before, or even precipitate, failure of thalamo-cortical transmission with the induction of unconsciousness... - Induction of depressed mood disrupts emotion regulation neurocircuitry and enhances pain unpleasantnessChantal Berna
Centre for Functional Magnetic Resonance Imaging of the Brain, Department of Clinical Neurology, University of Oxford, Oxford, United Kingdom
Biol Psychiatry 67:1083-90. 2010..We hypothesized that dysregulation of the neural circuitry underlying emotion regulation is the mechanism whereby pain processing is affected during depressed mood... 
An fMRI study exploring the overlap and differences between neural representations of physical and recalled painMerle Fairhurst
Nuffield Division Anaesthetics, Nuffield Department Clinical Neurosciences, Centre for Functional Magnetic Resonance Imaging of the Brain, University of Oxford, Oxford, England, United Kingdom
PLoS ONE 7:e48711. 2012..Together, these observations further our understanding of centrally-mediated pain experiences and pain memory as well as the potential relevance of these factors in the maintenance of chronic pain...- Opioids depress cortical centers responsible for the volitional control of respirationKyle T S Pattinson
Nuffield Department of Anaesthetics, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom
J Neurosci 29:8177-86. 2009..Opioids have profound effects on the cortical centers that control breathing, which potentiates their actions in the brainstem... - Identifying brain activity specifically related to the maintenance and perceptual consequence of central sensitization in humansMichael C Lee
Department of Clinical Neurology, Centre for Functional Magnetic Resonance Imaging of the Brain, University of Oxford, Oxford, United Kingdom
J Neurosci 28:11642-9. 2008.... - Stimulus site and modality dependence of functional activity within the human spinal cordJonathan C W Brooks
Centre for Functional Magnetic Resonance Imaging of the Brain, Nuffield Department of Clinical Neurosciences, Nuffield Division of Anaesthetics, University of Oxford, Oxford OX3 9DU, UK
J Neurosci 32:6231-9. 2012..The development of these techniques opens the path to understanding, at a subject-specific level, central sensitization processes that contribute to chronic pain states... - Flexible cerebral connectivity patterns subserve contextual modulations of painMarkus Ploner
FMRIB Centre and Nuffield Department of Anaesthetics, University of Oxford, Oxford OX3 9DU, UK
Cereb Cortex 21:719-26. 2011.... - Measurement of relative cerebral blood volume using BOLD contrast and mild hypoxic hypoxiaRichard G Wise
Department of Clinical Neurology, Centre for Functional Magnetic Resonance Imaging of the Brain, John Radcliffe Hospital, University of Oxford, Oxford, UK
Magn Reson Imaging 28:1129-34. 2010..5 ± 0.2 (mean ± S.D.) for cortical gray matter to white matter and 1.0 ± 0.3 for cortical gray matter to deep gray matter... - Determination of the human brainstem respiratory control network and its cortical connections in vivo using functional and structural imagingKyle T S Pattinson
Nuffield Department of Anaesthetics, University of Oxford, John Radcliffe Hospital, Oxford, UK
Neuroimage 44:295-305. 2009..From these results we speculate that the thalamus plays an important role in integrating respiratory signals to and from the brainstem respiratory centres... - Baseline reward circuitry activity and trait reward responsiveness predict expression of opioid analgesia in healthy subjectsVishvarani Wanigasekera
Centre for Functional Magnetic Resonance Imaging of the Brain, Nuffield Department of Clinical Neurosciences, Nuffield Division of Anaesthetics, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DU, United Kingdom
Proc Natl Acad Sci U S A 109:17705-10. 2012..These results support the notion of future imaging-based subject-stratification paradigms that can guide therapeutic decisions... - Neurocognitive aspects of pain perceptionKatja Wiech
Nuffield Department of Anaesthetics, University of Oxford, John Radcliffe Hospital, Headley Way, Oxford OX3 9DU, UK
Trends Cogn Sci 12:306-13. 2008..Taking placebo-induced analgesia as an example, we discuss the contribution of attention, expectation and reappraisal as three basic mechanisms that are important for the cognitive modulation of pain... - Anticipatory brainstem activity predicts neural processing of pain in humansMerle Fairhurst
Department of Physiology, Anatomy and Genetics, Department of Clinical Neurology, University of Oxford, Oxford OX1 3QX, United Kingdom
Pain 128:101-10. 2007..Together, the results suggest a possible role of brainstem areas in anticipatory mechanisms involved in the maintenance of chronic pain... - Cortical processing of visceral and somatic stimulation: differentiating pain intensity from unpleasantnessP Dunckley
Department of Human Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, UK
Neuroscience 133:533-42. 2005..We believe that the observed patterns of activation represent the differences in cortical process of interoceptive (visceral) and exteroceptive (somatic) stimuli when matched for unpleasantness... - Pharmacological FMRI: measuring opioid effects on the BOLD response to hypercapniaKyle T S Pattinson
Nuffield Department of Anaesthetics, Oxford University, John Radcliffe Hospital, Oxford, UK
J Cereb Blood Flow Metab 27:414-23. 2007..We suggest that similar methodology should be used when investigating other potentially vasoactive compounds with FMRI... - Prestimulus functional connectivity determines pain perception in humansMarkus Ploner
Oxford Centre for Functional Magnetic Resonance Imaging of Brain, Department of Clinical Neurology, University of Oxford, UK
Proc Natl Acad Sci U S A 107:355-60. 2010..We conclude that variations in functional connectivity underlie personality-related differences in individual susceptibility to pain... - Determining anatomical connectivities between cortical and brainstem pain processing regions in humans: a diffusion tensor imaging study in healthy controlsGeorge Hadjipavlou
Pain Imaging Neuroscience (PaIN) Group, Department of Physiology, Anatomy and Genetics, Oxford University, South Parks Road, Oxford OX1 3QX, UK
Pain 123:169-78. 2006..The connections identified confirm the existence of an anatomical circuitry for the functionally characterised top-down influences on pain processing via brainstem structures in humans... - Pain relief as an opponent process: a psychophysical investigationSiri Leknes
Oxford Centre for Functional MRI of the Brain, Clinical Neurology and Nuffield Department of Anaesthetics, Oxford University, John Radcliffe Hospital, Oxford, UK
Eur J Neurosci 28:794-801. 2008..Importantly, the high relief pleasantness ratings confirmed the hypothesized link between relief and reward... - Amygdala activity contributes to the dissociative effect of cannabis on pain perceptionMichael C Lee
Centre for Functional MRI ofBrain FMRIB, Department of Clinical Neurology, University of Oxford, Oxford, UK
Pain 154:124-34. 2013..Instead, the data reveal that amygdala activity contributes to interindividual response to cannabinoid analgesia, and suggest that dissociative effects of THC in the brain are relevant to pain relief in humans... - The anxiolytic effects of midazolam during anticipation to pain revealed using fMRIRichard G Wise
Department of Clinical Neurology, Centre for Functional Magnetic Resonance Imaging of the Brain FMRIB, University of Oxford, John Radcliffe Hospital, OX3 9DU Oxford, UK
Magn Reson Imaging 25:801-10. 2007..We present a pharmacological functional magnetic resonance imaging (fMRI) study in which we investigate the selective modulation by midazolam of brain activity associated with anticipation to pain compared to pain itself... - Regions of interest analysis in pharmacological fMRI: how do the definition criteria influence the inferred result?Georgios D Mitsis
Centre for Functional Magnetic Resonance Imaging of the Brain FMRIB, Department of Clinical Neurology, University of Oxford, Oxford, UK
Neuroimage 40:121-32. 2008..For these reasons, fROIs should be employed with caution when it is not possible to make clear anatomical prior hypotheses... - Psychophysical and functional imaging evidence supporting the presence of central sensitization in a cohort of osteoarthritis patientsStephen E Gwilym
University of Oxford, Oxford, UK
Arthritis Rheum 61:1226-34. 2009..We aimed to identify the supraspinal influences that underlie these clinical manifestations that we consider indicative of possible central sensitization... - Dynamic forcing of end-tidal carbon dioxide and oxygen applied to functional magnetic resonance imagingRichard G Wise
Centre for Functional Magnetic Resonance Imaging of the Brain, Department of Clinical Neurology, University of Oxford, John Radcliffe Hospital, Oxford, UK
J Cereb Blood Flow Metab 27:1521-32. 2007..The DEF system can provide flexible, convenient, and physiologically well-controlled respiratory challenges in the MRI environment for mapping dynamic responses of the cerebrovasculature... - Pharmacological FMRI in the development of new analgesic compoundsPetra Schweinhardt
Pain Imaging Neuroscience Group, Department Physiology, Anatomy and Genetics, Oxford University, Oxford, UK
NMR Biomed 19:702-11. 2006..We are therefore optimistic that phFMRI will be used as a tool with high sensitivity and specificity for evaluating analgesic agents in early drug development and clinical studies... - Brainstem functional imaging in humansIrene Tracey
Human Anatomy and Genetics Department, Centre for Functional Magnetic Resonance Imaging of the Brain, Oxford University, South Parks Road, Oxford OX1 3QX, UK
Suppl Clin Neurophysiol 58:52-67. 2006 - An fMRI study of cerebral processing of brush-evoked allodynia in neuropathic pain patientsPetra Schweinhardt
Department of Human Anatomy and Genetics, Oxford University, South Parks Road, Oxford OX1 1QX, UK
Neuroimage 32:256-65. 2006..Taken together, our data and the literature review suggest a functional segregation of anterior insular cortex... - Combining fMRI with a pharmacokinetic model to determine which brain areas activated by painful stimulation are specifically modulated by remifentanilRichard G Wise
Centre for Functional Magnetic Resonance Imaging of the Brain, Department of Clinical Neurology, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DU, United Kingdom
Neuroimage 16:999-1014. 2002..The method of examining time-dependent pharmacological modulation of specific brain activity may be generalized to other drugs that modulate brain activity other than that associated with pain... - Presence of mental imagery associated with chronic pelvic pain: a pilot studyChantal Berna
Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK
Pain Med 12:1086-93. 2011..To ascertain whether a small sample of patients with chronic pelvic pain experienced any pain-related cognitions in the form of mental images... - Relief as a reward: hedonic and neural responses to safety from painSiri Leknes
Nuffield Division of Anaesthetics, Nuffield Department of Clinical Neurosciences, Centre for Functional Magnetic Resonance Imaging of the Brain FMRIB, University of Oxford, Oxford, Oxfordshire, United Kingdom
PLoS ONE 6:e17870. 2011..In conclusion, relief differs from appetitive rewards due to its reliance on negative expectations, the violation of which is reflected in relief-related accumbens activation... - The effect of treatment expectation on drug efficacy: imaging the analgesic benefit of the opioid remifentanilUlrike Bingel
Oxford Centre for Functional MRI of the Brain, Nuffield Department of Clinical Neurosciences Division of Anaesthetics, University of Oxford, OX3 9DU Oxford, UK
Sci Transl Med 3:70ra14. 2011..We propose that it may be necessary to integrate patients' beliefs and expectations into drug treatment regimes alongside traditional considerations in order to optimize treatment outcomes... - Anterior insula integrates information about salience into perceptual decisions about painKatja Wiech
Nuffield Department of Anaesthetics, University of Oxford, John Radcliffe Hospital, Oxford, UK
J Neurosci 30:16324-31. 2010..These findings provide evidence that the anterior insula and MCC as a "salience network" integrate information about the significance of an impending stimulation into perceptual decision-making in the context of pain... - Thalamic atrophy associated with painful osteoarthritis of the hip is reversible after arthroplasty: a longitudinal voxel-based morphometric studyStephen E Gwilym
University of Oxford, Oxford, UK
Arthritis Rheum 62:2930-40. 2010..From this previous work, it appears that chronic pain is associated with altered brain morphology. The present study was undertaken to assess these potential alterations in patients with painful hip osteoarthritis (OA)... - From nociception to pain perception: imaging the spinal and supraspinal pathwaysJonathan Brooks
Pain Imaging Neuroscience Group, Department of Human Anatomy and Genetics, University of Oxford, UK
J Anat 207:19-33. 2005..The ultimate goal of such research is to take these new techniques into the clinic, to investigate and provide new remedies for chronic pain sufferers... - Neuroanatomy of impaired self-awareness in Alzheimer's disease and mild cognitive impairmentGiovanna Zamboni
Oxford Project to Investigate Memory and Ageing OPTIMA, Nuffield Department of Clinical Medicine, University of Oxford, UK
Cortex 49:668-78. 2013..In the present study we aimed to explore the functional correlates of self-awareness in patients with MCI and AD... - Brain imaging reveals that engagement of descending inhibitory pain pathways in healthy women in a low endogenous estradiol state varies with testosteroneKaty Vincent
Centre for Functional Magnetic Resonance Imaging of the Brain, Nuffield Department of Clinical Neurosciences, Nuffield Division of Anaesthetics, University of Oxford, UK
Pain 154:515-24. 2013..Specifically, failure to engage descending inhibition at the level of the rostral ventromedial medulla may be responsible for the reduction in temperature required by COCP users with low circulating testosterone... - Decoding the perception of pain from fMRI using multivariate pattern analysisKay H Brodersen
Centre for Functional Magnetic Resonance Imaging of the Brain FMRIB, Nuffield Department of Clinical Neurosciences, Nuffield Division Anaesthetics, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK
Neuroimage 63:1162-70. 2012..In addition to its utility in establishing structure-function mappings, our approach affords trial-by-trial predictions and thus represents a step towards the goal of establishing an objective neuronal marker of pain perception... - Imaging how attention modulates pain in humans using functional MRISusanna J Bantick
Oxford University Department of Clinical Neurology, Centre for Functional Magnetic Resonance Imaging of the Brain, John Radcliffe Hospital, Headington, Oxford, UK
Brain 125:310-9. 2002..In contrast, many areas of the pain matrix (i.e. thalamus, insula, cognitive division of the ACC) displayed reduced activation, supporting the behavioural results of reduced pain perception... - Using fMRI to quantify the time dependence of remifentanil analgesia in the human brainRichard G Wise
Department of Clinical Neurology, Centre for Functional Magnetic Resonance Imaging of the Brain, University of Oxford, John Radcliffe Hospital, Oxford, UK
Neuropsychopharmacology 29:626-35. 2004..Comparison of the time course of regional brain activity with pain perception could reveal those regions engaged in drug-induced analgesia... - Itch and motivation to scratch: an investigation of the central and peripheral correlates of allergen- and histamine-induced itch in humansSiri G Leknes
Department of Physiology, Anatomy and Genetics, University of Oxford, South Parks Rd, Oxford OX1 3QX, UK
J Neurophysiol 97:415-22. 2007..g., addiction and obsessive compulsive disorder. The patterns of itch-induced activation reported here may help explain why chronic itch sufferers frequently self-harm through uncontrollable itch-scratch cycles... - Imaging pain in patients: is it meaningful?Petra Schweinhardt
Department of Physiology, Anatomy and Genetics, Oxford University, Oxford, Oxford, UK
Curr Opin Neurol 19:392-400. 2006..The timing is ideal to assess the utility of data generated from these studies... - Quantitative assessment of the reproducibility of functional activation measured with BOLD and MR perfusion imaging: implications for clinical trial designTeddy Tjandra
Oxford Centre for Functional Magnetic Resonance Imaging of the Brain, Department of Clinical Neurology, University of Oxford, England, UK
Neuroimage 27:393-401. 2005..In addition, the reduction of variance over time using CBF measurements (non-significant) suggests it could potentially provide a more useful approach when assessing longitudinal activation changes... - Neuroimaging as a tool for pain diagnosis and analgesic developmentKarolina Wartolowska
Centre for Functional Magnetic Resonance Imaging of Brain, Department of Clinical Neurology, and Nuffield Department of Anaesthetics, University of Oxford, Oxford, England, OX3 9DU, United Kingdom
Neurotherapeutics 6:755-60. 2009..Moreover, neuroimaging shows promising results for analgesic drug development and in characterizing different types of pain, bringing us closer to development of mechanism-based diagnoses and treatments for the chronic pain patient... - Cold or calculating? Reduced activity in the subgenual cingulate cortex reflects decreased emotional aversion to harming in counterintuitive utilitarian judgmentKatja Wiech
Nuffield Department of Clinical Neurosciences, Nuffield Division Anaesthetics, University of Oxford, John Radcliffe Hospital, Headley Way, Oxford OX3 9DU, UK Oxford Centre for Functional Magnetic Resonance Imaging of the Brain, Nuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, Headley Way, Oxford OX3 9DU, UK Electronic address
Cognition 126:364-72. 2013..It may rather reflect a lack of empathic concern, and diminished aversion to harming others... - Dysmenorrhoea is associated with central changes in otherwise healthy womenKaty Vincent
Centre for Functional Magnetic Resonance Imaging of the Brain, Nuffield Department of Clinical Neurosciences, Nuffield Division Anaesthetics, University of Oxford, UK
Pain 152:1966-75. 2011..These findings indicate the potential importance of early and adequate treatment of dysmenorrhoea... - A comparison of visceral and somatic pain processing in the human brainstem using functional magnetic resonance imagingPaul Dunckley
Department of Human Anatomy and Genetics, University of Oxford, Oxford OX1 3QX, United Kingdom
J Neurosci 25:7333-41. 2005..05, Pearson's r, two-tailed) but not somatic stimulation. We propose that the differences in NCF and right PAG activation observed may represent a greater nocifensive response and greater emotive salience of visceral over somatic pain... - Imaging CNS modulation of pain in humansUlrike Bingel
Department of Neurology, NeuroImage Nord, University Medical Center Hamburg Eppendorf, Germany
Physiology (Bethesda) 23:371-80. 2008..Research on the involved circuitry and implemented mechanisms is a major focus of contemporary neuroscientific research in the field of pain and should provide new insights to prevent and treat chronic pain states... - Physiological noise modelling for spinal functional magnetic resonance imaging studiesJonathan C W Brooks
PAIN Group, Department of Physiology Anatomy and Genetics, Le Gros Clark Building, South Parks Road, Oxford OX1 3QX, UK
Neuroimage 39:680-92. 2008.... - Blood oxygenation level dependent functional magnetic resonance imaging: current and potential uses in obstetrics and gynaecologyK Vincent
Nuffield Department of Obstetrics and Gynaecology, Oxford University, John Radcliffe Hospital, Headley Way, Oxford, OX3 9DU, UK
BJOG 116:240-6. 2009..Finally we review some of the more novel applications of the technique, such as imaging of pelvic floor function and the effects of hypoxia on the fetus... - Importance of anti- and pro-nociceptive mechanisms in human diseaseI Tracey
Pain Imaging Neuroscience (PaIN) Group, Human Anatomy and Genetics Department, FMRIB Centre, Oxford University, South Parks Rd, Oxford OX1 3QX, UK
Gut 53:1553-5. 2004 - Operculoinsular cortex encodes pain intensity at the earliest stages of cortical processing as indicated by amplitude of laser-evoked potentials in humansG D Iannetti
Department of Human Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, UK
Neuroscience 131:199-208. 2005.... - Simultaneous recording of laser-evoked brain potentials and continuous, high-field functional magnetic resonance imaging in humansG D Iannetti
Department of Human Anatomy and Genetics, University of Oxford, Oxford, UK
Neuroimage 28:708-19. 2005..Truly simultaneous recording of LEPs and fMRI is still desirable in specific experimental conditions, such as single-trial, learning, and pharmacological studies... - Pharmacological modulation of pain-related brain activity during normal and central sensitization states in humansG D Iannetti
Department of Human Anatomy and Genetics, and Centre for Functional Magnetic Resonance Imaging of the Brain, University of Oxford, UK
Proc Natl Acad Sci U S A 102:18195-200. 2005.... - Adelta nociceptor response to laser stimuli: selective effect of stimulus duration on skin temperature, brain potentials and pain perceptionG D Iannetti
Department of Human Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, UK
Clin Neurophysiol 115:2629-37. 2004..To disclose a possible effect of duration of pulsed laser heat stimuli on Adelta nociceptor responses, skin temperature profiles, brain evoked potentials and pain perception... - Similar nociceptive afferents mediate psychophysical and electrophysiological responses to heat stimulation of glabrous and hairy skin in humansG D Iannetti
Department of Physiology, Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, UK
J Physiol 577:235-48. 2006..e. CO(2) laser) as stimulation procedure... - Exacerbation of pain by anxiety is associated with activity in a hippocampal networkA Ploghaus
Oxford Centre for Functional Magnetic Resonance Imaging of the Brain, Department of Clinical Neurology, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom
J Neurosci 21:9896-903. 2001..It supports the proposal that during anxiety, the hippocampal formation amplifies aversive events to prime behavioral responses that are adaptive to the worst possible outcome... - Learning about pain: the neural substrate of the prediction error for aversive eventsA Ploghaus
Centre for Functional MRI of the Brain, Department of Clinical Neurology, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom
Proc Natl Acad Sci U S A 97:9281-6. 2000..Searching for interventions to specifically modulate activation of these brain regions therefore offers an approach to identifying new treatments for chronic pain, which often has a substantial associative learning component... - Dissociating pain from its anticipation in the human brainA Ploghaus
Centre for Functional Magnetic Resonance Imaging of the Brain, Department of Clinical Neurology, University of Oxford, Oxford OX3 9DU, UK
Science 284:1979-81. 1999..Selective manipulations of activity at these sites may offer therapeutic possibilities for treating chronic pain... - Cerebellar responses during anticipation of noxious stimuli in subjects recovered from depression. Functional magnetic resonance imaging studyK A Smith
University Department of Psychiatry, Warneford Hospital, Oxford, UK
Br J Psychiatry 181:411-5. 2002..CONCLUSIONS: Our data suggest that abnormal cerebellar function could be a marker of vulnerability to recurrent depression. This could provide a new target for therapeutic interventions... - An in vivo and in vitro H-magnetic resonance spectroscopy study of mdx mouse brain: abnormal development or neural necrosis?I Tracey
MRC Biochemical and Clinical Magnetic Resonance Unit, Department of Biochemistry, Oxford University, UK
J Neurol Sci 141:13-8. 1996..In contrast, choline compounds and myo-inositol levels were increased, indicative of gliosis or developmental abnormalities in dystrophic brain... - Somatotopic organisation of the human insula to painful heat studied with high resolution functional imagingJ C W Brooks
Department of Human Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, UK
Neuroimage 27:201-9. 2005..037). Based on single subject analyses, the average standard space (MNI) coordinates for face, hand and foot activity were (-40,-16,11), (-40,-19,14) and (-35,-21,11) respectively... - Remembering John Newsom-Davis' contribution to human imaging in OxfordP M Matthews
Centre for Functional MRI of the Brain and Department of Clinical Neurology, John Radcliffe Hospital, University of Oxford, United Kingdom
J Neuroimmunol 201:250-4. 2008.... - The importance of context: when relative relief renders pain pleasantSiri Leknes
Centre for Functional Magnetic Resonance Imaging of the Brain, Nuffield Department of Clinical Neurosciences Nuffield Division of Anaesthetics, University of Oxford, Oxford, UK
Pain 154:402-10. 2013..The findings of this study point to a role for brainstem and reward circuitry in a context-induced "hedonic flip" of pain... - Structural changes of the brain in rheumatoid arthritisKarolina Wartolowska
Oxford Centre for Functional Magnetic Resonance Imaging of the Brain and University of Oxford, Oxford, UK
Arthritis Rheum 64:371-9. 2012..To investigate whether structural changes are present in the cortical and subcortical gray matter of the brains of patients with rheumatoid arthritis (RA)... - Assessment of physiological noise modelling methods for functional imaging of the spinal cordYazhuo Kong
Centre for Functional Magnetic Resonance Imaging of the Brain FMRIB, University of Oxford, Oxford, UK
Neuroimage 60:1538-49. 2012..Pre-whitening was found to reduce non-white noise, which was not accounted for by physiological noise correction, and decrease false positive detection rates... - Resting fluctuations in arterial carbon dioxide induce significant low frequency variations in BOLD signalRichard G Wise
Centre for Functional Magnetic Resonance Imaging of the Brain, Department of Clinical Neurology, John Radcliffe Hospital, University of Oxford, Oxford, UK
Neuroimage 21:1652-64. 2004..These fluctuations are a source of physiological noise and a potentially important confounding factor in fMRI paradigms that modify breathing. However, they can also be used for mapping regional vascular responsiveness to CO(2)... - Neural correlates of an injury-free model of central sensitization induced by opioid withdrawal in humansVishvarani Wanigasekera
Centre for Functional Magnetic Resonance Imaging of the Brain, Nuffield Department of Clinical Neurosciences, Division of Anaesthetics, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DU, United Kingdom
J Neurosci 31:2835-42. 2011.... - An investigation to dissociate the analgesic and anesthetic properties of ketamine using functional magnetic resonance imagingRichard Rogers
Nuffield Department of Anesthetics, John Radcliffe Hospital, Oxford, Oxfordshire, OX3 9DU, United Kingdom
Anesthesiology 100:292-301. 2004..The aim of this study was to determine whether the analgesic effects of ketamine could be imaged... - An fMRI study measuring analgesia enhanced by religion as a belief systemKatja Wiech
Nuffield Department of Anaesthetics, University of Oxford, John Radcliffe Hospital, Oxford, UK
Pain 139:467-76. 2008..We suggest that religious belief might provide a framework that allows individuals to engage known pain-regulatory brain processes... - Nociceptive processing in the human brainIrene Tracey
Department Human Anatomy and Genetics, Centre for Functional Magnetic Resonance Imaging of the Brain, Oxford University, Oxford OX1 3QX, England, UK
Curr Opin Neurobiol 15:478-87. 2005..The result has produced a dramatic shift in our thinking about the neural circuitry involved in nociceptive processing, revealing that pain is much more than a submodality of the sense of touch... - The influence of negative emotions on pain: behavioral effects and neural mechanismsKatja Wiech
Nuffield Department of Anaesthetics, University of Oxford, John Radcliffe Hospital, Headley Way, Oxford OX3 9DU, UK
Neuroimage 47:987-94. 2009..We discuss possible neural mechanisms underlying this modulatory influence focusing on the periaqueductal grey (PAG), amygdala, anterior cingulate cortex (ACC) and anterior insula as key players in both, pain and affective processing... - Investigation into the neural correlates of emotional augmentation of clinical painPetra Schweinhardt
Centre for Functional Magnetic Resonance Imaging, Department of Clinical Neurology, John Radcliffe Hospital, Oxford, OX3 9DU, UK
Neuroimage 40:759-66. 2008.... - A role for the brainstem in central sensitisation in humans. Evidence from functional magnetic resonance imagingL Zambreanu
Pain Imaging Neuroscience (PaIN) Group, Department of Human Anatomy and Genetics, Oxford University, South Parks Road, Oxford OX1 3QX, UK
Pain 114:397-407. 2005..These results suggest that structures in the mesencephalic reticular formation, possibly the NCF and PAG, are involved in central sensitisation in humans... - A 31P-NMR study of muscle exercise metabolism in mdx mice: evidence for abnormal pH regulationJ F Dunn
Dept of Biochemistry, University of Oxford, UK
J Neurol Sci 113:108-13. 1992..This provides more evidence of impaired ionic regulation in dystrophic muscle and could be used as an index for the evaluation in vivo of therapeutic interventions such as myoblast transfer or gene replacement therapy... - Structural and functional bases of visuospatial associative memory in older adultsGiovanna Zamboni
Oxford Project to Investigate Memory and Ageing OPTIMA, Experimental Medicine Division of Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK
Neurobiol Aging 34:961-72. 2013.... - The role of fMRI in drug discoveryRichard G Wise
Pain Imaging Neuroscience Group, Department of Human Anatomy and Genetics, University of Oxford, South Parks Road, Oxford, UK
J Magn Reson Imaging 23:862-76. 2006..In future, pharmacological fMRI is likely to extend to examinations of the spinal cord and into pharmacogenetics to relate genetic polymorphisms to differential responses of the brain to drugs... - A common neurobiology for pain and pleasureSiri Leknes
Oxford Centre for Functional MRI of the Brain, Department of Clinical Neurology, Oxford University, John Radcliffe Hospital, Oxford, OX3 9DU, UK
Nat Rev Neurosci 9:314-20. 2008..Understanding the mutually inhibitory effects that pain and reward processing have on each other, and the neural mechanisms that underpin such modulation, is important for alleviating unnecessary suffering and improving well-being... - Counter-stimulatory effects on pain perception and processing are significantly altered by attention: an fMRI studyS E Longe
Centre for Functional Magnetic Resonance Imaging of the Brain (FMRIB, Dept of Clinical Neurology, University of Oxford, John Radcliffe Hospital, Headley Way, Oxford, OX3 9DU, UK
Neuroreport 12:2021-5. 2001..These results suggest attention plays an important part in the pain relief experienced from counter-stimulation... - Brain metabolism is abnormal in the mdx model of Duchenne muscular dystrophyI Tracey
Department of Biochemistry, Oxford University, UK
Brain 119:1039-44. 1996..It is proposed that these biochemical changes may be a factor in the reduced cognitive capacity of mdx mice and some DMD children... - Attentional modulation of visceral and somatic painP Dunckley
Department of Physiology, Anatomy and Genetics, Oxford, UK
Neurogastroenterol Motil 19:569-77. 2007..These results suggest that pain intensity perception during attentional modulation is reflected in the primary somatosensory cortex (visceral pain) and aIns cortex activity (somatic pain)... - Imaging the neural correlates of neuropathic pain and pleasurable relief associated with inherited erythromelalgia in a single subject with quantitative arterial spin labellingAndrew R Segerdahl
Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, Oxfordshire, UK
Pain 153:1122-7. 2012..This combined approach allowed us to confirm the presence of a temperature-sensitive channelopathy of peripheral neurons and to investigate the neural correlates of tonic neuropathic pain and relief in a single subject... - Sex hormones and pain: the evidence from functional imagingKaty Vincent
Functional Magnetic Resonance Imaging of the Brain Centre, Department of Clinical Neurology, University of Oxford, John Radcliffe Hospital, Headley Way, Oxford, OX3 9DU, UK
Curr Pain Headache Rep 14:396-403. 2010..Finally, we conclude by considering how results of studies imaging the influence of sex hormones in related areas such as emotion and cognition also may inform our understanding of this complex area... - A 31P-magnetic resonance spectroscopy and biochemical study of the mo(vbr) mouse: potential model for the mitochondrial encephalomyopathiesI Tracey
Department of Biochemistry, Oxford University, United Kingdom
Muscle Nerve 20:1352-9. 1997..The PCr recovery rate, measured by 31P-MRS, was sensitive to the muscle abnormality. This strain is best described as having chronic mitochondrial dysfunction... - Functional connectivity and pain: how effectively connected is your brain?Irene Tracey
Pain 116:173-4. 2005 - Lateralisation of nociceptive processing in the human brain: a functional magnetic resonance imaging studyPaula D Youell
Human Pain Research Group, University of Manchester Rheumatic Diseases Centre, Hope Hospital, Salford M6 8HD, UK
Neuroimage 23:1068-77. 2004.... - Functional responses in the human spinal cord during willed motor actions: evidence for side- and rate-dependent activityMarta Maieron
Dipartimento di Scienze Biomediche, Universita di Modena e Reggio Emilia, 41100 Modena, Italy
J Neurosci 27:4182-90. 2007.... - Evidence for asymmetric frontal-lobe involvement in episodic memory from functional magnetic resonance imaging and patients with unilateral frontal-lobe excisionsAndy C H Lee
MRC Cognition and Brain Sciences Unit, 15 Chaucer Road, CB2 2EF, Cambridge, UK
Neuropsychologia 40:2420-37. 2002..This result suggests that the memory-related asymmetries observed during functional neuroimaging studies may not be critical for task performance...