Irene Tracey

Summary

Affiliation: University of Oxford
Country: UK

Publications

  1. doi request reprint How neuroimaging studies have challenged us to rethink: is chronic pain a disease?
    Irene Tracey
    Oxford Centre for Functional Magnetic Resonance Imaging of the Brain, Nuffield Department of Anaesthetics, University of Oxford, John Radcliffe Hospital, Headington, England, UK
    J Pain 10:1113-20. 2009
  2. doi request reprint Getting the pain you expect: mechanisms of placebo, nocebo and reappraisal effects in humans
    Irene Tracey
    Nuffield Department of Anaesthetics and Oxford Centre for Functional Magnetic Resonance Imaging of the Brain, Department of Clinical Neurology, University of Oxford, Oxford, UK
    Nat Med 16:1277-83. 2010
  3. doi request reprint Can neuroimaging studies identify pain endophenotypes in humans?
    Irene Tracey
    Oxford Center for Functional Magnetic Resonance Imaging of the Brain, Nuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK
    Nat Rev Neurol 7:173-81. 2011
  4. ncbi request reprint Imaging pain
    I Tracey
    Centre for Functional Magnetic Resonance Imaging of the Brain, Department of Clinical Neurology, Oxford University, John Radcliffe Hospital, Headington, Oxford, UK
    Br J Anaesth 101:32-9. 2008
  5. ncbi request reprint Imaging attentional modulation of pain in the periaqueductal gray in humans
    Irene Tracey
    Centre for Functional Magnetic Resonance Imaging of the Brain, Department of Clinical Neurology, University of Oxford, Oxford OX3 9DU, United Kingdom
    J Neurosci 22:2748-52. 2002
  6. doi request reprint Neuroimaging of pain mechanisms
    Irene Tracey
    Centre for Functional Magnetic Resonance Imaging of the Brain, Departments of Clinical Neurology and Nuffield Department of Anaesthetics, Oxford University, Oxford, UK
    Curr Opin Support Palliat Care 1:109-16. 2007
  7. ncbi request reprint The cerebral signature for pain perception and its modulation
    Irene Tracey
    Centre for Functional Magnetic Resonance Imaging of the Brain, Clinical Neurology and Nuffield Department of Anaesthetics, Oxford University, OX3 9DU Oxford, England, UK
    Neuron 55:377-91. 2007
  8. ncbi request reprint Slow-wave activity saturation and thalamocortical isolation during propofol anesthesia in humans
    Roisin Ni Mhuircheartaigh
    Oxford Centre for Functional Magnetic Resonance Imaging of the Brain and Nuffield Division of Anaesthetics, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford OX3 9DU, UK
    Sci Transl Med 5:208ra148. 2013
  9. doi request reprint Cortical and subcortical connectivity changes during decreasing levels of consciousness in humans: a functional magnetic resonance imaging study using propofol
    Roisin Ni Mhuircheartaigh
    Centre for Functional Magnetic Resonance of the Brain FMRIB, Department of Clinical Neurology and Nuffield Department of Anaesthetics, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom
    J Neurosci 30:9095-102. 2010
  10. doi request reprint Brain imaging reveals that engagement of descending inhibitory pain pathways in healthy women in a low endogenous estradiol state varies with testosterone
    Katy Vincent
    Centre for Functional Magnetic Resonance Imaging of the Brain, Nuffield Department of Clinical Neurosciences, Nuffield Division of Anaesthetics, University of Oxford, UK
    Pain 154:515-24. 2013

Collaborators

Detail Information

Publications96

  1. doi request reprint How neuroimaging studies have challenged us to rethink: is chronic pain a disease?
    Irene Tracey
    Oxford Centre for Functional Magnetic Resonance Imaging of the Brain, Nuffield Department of Anaesthetics, University of Oxford, John Radcliffe Hospital, Headington, England, UK
    J Pain 10:1113-20. 2009
    ..We discuss these observations within the framework of the current definition of a disease...
  2. doi request reprint Getting the pain you expect: mechanisms of placebo, nocebo and reappraisal effects in humans
    Irene Tracey
    Nuffield Department of Anaesthetics and Oxford Centre for Functional Magnetic Resonance Imaging of the Brain, Department of Clinical Neurology, University of Oxford, Oxford, UK
    Nat Med 16:1277-83. 2010
    ..The findings have relevance for chronic pain states and other disorders, where abnormal functioning of crucial brain regions might affect analgesic outcome even in the normal therapeutic setting...
  3. doi request reprint Can neuroimaging studies identify pain endophenotypes in humans?
    Irene Tracey
    Oxford Center for Functional Magnetic Resonance Imaging of the Brain, Nuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK
    Nat Rev Neurol 7:173-81. 2011
    ..This endophenotypic approach-the focus of this Review-simplifies the connection between genes and behavior and is needed for complex disorders like chronic pain...
  4. ncbi request reprint Imaging pain
    I Tracey
    Centre for Functional Magnetic Resonance Imaging of the Brain, Department of Clinical Neurology, Oxford University, John Radcliffe Hospital, Headington, Oxford, UK
    Br J Anaesth 101:32-9. 2008
    ..In this review, I shall briefly summarize our current state of knowledge regarding the central representation of pain perception in varying situations...
  5. ncbi request reprint Imaging attentional modulation of pain in the periaqueductal gray in humans
    Irene Tracey
    Centre for Functional Magnetic Resonance Imaging of the Brain, Department of Clinical Neurology, University of Oxford, Oxford OX3 9DU, United Kingdom
    J Neurosci 22:2748-52. 2002
    ..This provides direct evidence supporting the notion that the periaqueductal gray is a site for higher cortical control of pain modulation in humans...
  6. doi request reprint Neuroimaging of pain mechanisms
    Irene Tracey
    Centre for Functional Magnetic Resonance Imaging of the Brain, Departments of Clinical Neurology and Nuffield Department of Anaesthetics, Oxford University, Oxford, UK
    Curr Opin Support Palliat Care 1:109-16. 2007
    ..It is timely, therefore, to review the advances in neuroimaging applications to pain...
  7. ncbi request reprint The cerebral signature for pain perception and its modulation
    Irene Tracey
    Centre for Functional Magnetic Resonance Imaging of the Brain, Clinical Neurology and Nuffield Department of Anaesthetics, Oxford University, OX3 9DU Oxford, England, UK
    Neuron 55:377-91. 2007
    ....
  8. ncbi request reprint Slow-wave activity saturation and thalamocortical isolation during propofol anesthesia in humans
    Roisin Ni Mhuircheartaigh
    Oxford Centre for Functional Magnetic Resonance Imaging of the Brain and Nuffield Division of Anaesthetics, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford OX3 9DU, UK
    Sci Transl Med 5:208ra148. 2013
    ..We conclude that SWA saturation is a potential individualized indicator of perception loss that could prove useful for monitoring depth of anesthesia and studying altered states of consciousness. ..
  9. doi request reprint Cortical and subcortical connectivity changes during decreasing levels of consciousness in humans: a functional magnetic resonance imaging study using propofol
    Roisin Ni Mhuircheartaigh
    Centre for Functional Magnetic Resonance of the Brain FMRIB, Department of Clinical Neurology and Nuffield Department of Anaesthetics, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom
    J Neurosci 30:9095-102. 2010
    ..This result has not been previously described and suggests that disruption of subcortical thalamo-regulatory systems may occur before, or even precipitate, failure of thalamo-cortical transmission with the induction of unconsciousness...
  10. doi request reprint Brain imaging reveals that engagement of descending inhibitory pain pathways in healthy women in a low endogenous estradiol state varies with testosterone
    Katy Vincent
    Centre for Functional Magnetic Resonance Imaging of the Brain, Nuffield Department of Clinical Neurosciences, Nuffield Division of Anaesthetics, University of Oxford, UK
    Pain 154:515-24. 2013
    ..Specifically, failure to engage descending inhibition at the level of the rostral ventromedial medulla may be responsible for the reduction in temperature required by COCP users with low circulating testosterone...
  11. pmc Amygdala activity contributes to the dissociative effect of cannabis on pain perception
    Michael C Lee
    Centre for Functional MRI ofBrain FMRIB, Department of Clinical Neurology, University of Oxford, Oxford, UK
    Pain 154:124-34. 2013
    ..Instead, the data reveal that amygdala activity contributes to interindividual response to cannabinoid analgesia, and suggest that dissociative effects of THC in the brain are relevant to pain relief in humans...
  12. doi request reprint Induction of depressed mood disrupts emotion regulation neurocircuitry and enhances pain unpleasantness
    Chantal Berna
    Centre for Functional Magnetic Resonance Imaging of the Brain, Department of Clinical Neurology, University of Oxford, Oxford, United Kingdom
    Biol Psychiatry 67:1083-90. 2010
    ..We hypothesized that dysregulation of the neural circuitry underlying emotion regulation is the mechanism whereby pain processing is affected during depressed mood...
  13. doi request reprint Resting functional connectivity reveals residual functional activity in Alzheimer's disease
    Giovanna Zamboni
    Oxford Project to Investigate Memory and Ageing, University of Oxford, United Kingdom
    Biol Psychiatry 74:375-83. 2013
    ..We combined resting fMRI and task fMRI to examine the correspondence between these methods in individuals with cognitive impairment...
  14. pmc An fMRI study exploring the overlap and differences between neural representations of physical and recalled pain
    Merle Fairhurst
    Nuffield Division Anaesthetics, Nuffield Department Clinical Neurosciences, Centre for Functional Magnetic Resonance Imaging of the Brain, University of Oxford, Oxford, England, United Kingdom
    PLoS ONE 7:e48711. 2012
    ..Together, these observations further our understanding of centrally-mediated pain experiences and pain memory as well as the potential relevance of these factors in the maintenance of chronic pain...
  15. doi request reprint Opioids depress cortical centers responsible for the volitional control of respiration
    Kyle T S Pattinson
    Nuffield Department of Anaesthetics, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom
    J Neurosci 29:8177-86. 2009
    ..Opioids have profound effects on the cortical centers that control breathing, which potentiates their actions in the brainstem...
  16. doi request reprint Identifying brain activity specifically related to the maintenance and perceptual consequence of central sensitization in humans
    Michael C Lee
    Department of Clinical Neurology, Centre for Functional Magnetic Resonance Imaging of the Brain, University of Oxford, Oxford, United Kingdom
    J Neurosci 28:11642-9. 2008
    ....
  17. pmc The importance of context: when relative relief renders pain pleasant
    Siri Leknes
    Centre for Functional Magnetic Resonance Imaging of the Brain, Nuffield Department of Clinical Neurosciences Nuffield Division of Anaesthetics, University of Oxford, Oxford, UK
    Pain 154:402-10. 2013
    ..The findings of this study point to a role for brainstem and reward circuitry in a context-induced "hedonic flip" of pain...
  18. doi request reprint Stimulus site and modality dependence of functional activity within the human spinal cord
    Jonathan C W Brooks
    Centre for Functional Magnetic Resonance Imaging of the Brain, Nuffield Department of Clinical Neurosciences, Nuffield Division of Anaesthetics, University of Oxford, Oxford OX3 9DU, UK
    J Neurosci 32:6231-9. 2012
    ..The development of these techniques opens the path to understanding, at a subject-specific level, central sensitization processes that contribute to chronic pain states...
  19. doi request reprint Measurement of relative cerebral blood volume using BOLD contrast and mild hypoxic hypoxia
    Richard G Wise
    Department of Clinical Neurology, Centre for Functional Magnetic Resonance Imaging of the Brain, John Radcliffe Hospital, University of Oxford, Oxford, UK
    Magn Reson Imaging 28:1129-34. 2010
    ..5 ± 0.2 (mean ± S.D.) for cortical gray matter to white matter and 1.0 ± 0.3 for cortical gray matter to deep gray matter...
  20. doi request reprint Determination of the human brainstem respiratory control network and its cortical connections in vivo using functional and structural imaging
    Kyle T S Pattinson
    Nuffield Department of Anaesthetics, University of Oxford, John Radcliffe Hospital, Oxford, UK
    Neuroimage 44:295-305. 2009
    ..From these results we speculate that the thalamus plays an important role in integrating respiratory signals to and from the brainstem respiratory centres...
  21. doi request reprint Flexible cerebral connectivity patterns subserve contextual modulations of pain
    Markus Ploner
    FMRIB Centre and Nuffield Department of Anaesthetics, University of Oxford, Oxford OX3 9DU, UK
    Cereb Cortex 21:719-26. 2011
    ....
  22. doi request reprint Neuroanatomy of impaired self-awareness in Alzheimer's disease and mild cognitive impairment
    Giovanna Zamboni
    Oxford Project to Investigate Memory and Ageing OPTIMA, Nuffield Department of Clinical Medicine, University of Oxford, UK
    Cortex 49:668-78. 2013
    ..In the present study we aimed to explore the functional correlates of self-awareness in patients with MCI and AD...
  23. pmc Baseline reward circuitry activity and trait reward responsiveness predict expression of opioid analgesia in healthy subjects
    Vishvarani Wanigasekera
    Centre for Functional Magnetic Resonance Imaging of the Brain, Nuffield Department of Clinical Neurosciences, Nuffield Division of Anaesthetics, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DU, United Kingdom
    Proc Natl Acad Sci U S A 109:17705-10. 2012
    ..These results support the notion of future imaging-based subject-stratification paradigms that can guide therapeutic decisions...
  24. doi request reprint Neurocognitive aspects of pain perception
    Katja Wiech
    Nuffield Department of Anaesthetics, University of Oxford, John Radcliffe Hospital, Headley Way, Oxford OX3 9DU, UK
    Trends Cogn Sci 12:306-13. 2008
    ..Taking placebo-induced analgesia as an example, we discuss the contribution of attention, expectation and reappraisal as three basic mechanisms that are important for the cognitive modulation of pain...
  25. ncbi request reprint Anticipatory brainstem activity predicts neural processing of pain in humans
    Merle Fairhurst
    Department of Physiology, Anatomy and Genetics, Department of Clinical Neurology, University of Oxford, Oxford OX1 3QX, United Kingdom
    Pain 128:101-10. 2007
    ..Together, the results suggest a possible role of brainstem areas in anticipatory mechanisms involved in the maintenance of chronic pain...
  26. ncbi request reprint Cortical processing of visceral and somatic stimulation: differentiating pain intensity from unpleasantness
    P Dunckley
    Department of Human Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, UK
    Neuroscience 133:533-42. 2005
    ..We believe that the observed patterns of activation represent the differences in cortical process of interoceptive (visceral) and exteroceptive (somatic) stimuli when matched for unpleasantness...
  27. pmc Cold or calculating? Reduced activity in the subgenual cingulate cortex reflects decreased emotional aversion to harming in counterintuitive utilitarian judgment
    Katja Wiech
    Nuffield Department of Clinical Neurosciences, Nuffield Division Anaesthetics, University of Oxford, John Radcliffe Hospital, Headley Way, Oxford OX3 9DU, UK
    Cognition 126:364-72. 2013
    ..It may rather reflect a lack of empathic concern, and diminished aversion to harming others...
  28. doi request reprint Pain relief as an opponent process: a psychophysical investigation
    Siri Leknes
    Oxford Centre for Functional MRI of the Brain, Clinical Neurology and Nuffield Department of Anaesthetics, Oxford University, John Radcliffe Hospital, Oxford, UK
    Eur J Neurosci 28:794-801. 2008
    ..Importantly, the high relief pleasantness ratings confirmed the hypothesized link between relief and reward...
  29. pmc Prestimulus functional connectivity determines pain perception in humans
    Markus Ploner
    Oxford Centre for Functional Magnetic Resonance Imaging of Brain, Department of Clinical Neurology, University of Oxford, UK
    Proc Natl Acad Sci U S A 107:355-60. 2010
    ..We conclude that variations in functional connectivity underlie personality-related differences in individual susceptibility to pain...
  30. ncbi request reprint Determining anatomical connectivities between cortical and brainstem pain processing regions in humans: a diffusion tensor imaging study in healthy controls
    George Hadjipavlou
    Pain Imaging Neuroscience PaIN Group, Department of Physiology, Anatomy and Genetics, Oxford University, South Parks Road, Oxford OX1 3QX, UK
    Pain 123:169-78. 2006
    ..The connections identified confirm the existence of an anatomical circuitry for the functionally characterised top-down influences on pain processing via brainstem structures in humans...
  31. ncbi request reprint Pharmacological FMRI: measuring opioid effects on the BOLD response to hypercapnia
    Kyle T S Pattinson
    Nuffield Department of Anaesthetics, Oxford University, John Radcliffe Hospital, Oxford, UK
    J Cereb Blood Flow Metab 27:414-23. 2007
    ..We suggest that similar methodology should be used when investigating other potentially vasoactive compounds with FMRI...
  32. pmc Phantom pain is associated with preserved structure and function in the former hand area
    Tamar R Makin
    FMRIB Centre, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford OX3 9DU, UK
    Nat Commun 4:1570. 2013
    ..Our results prompt a revisiting of the link between phantom pain and brain organization...
  33. ncbi request reprint The anxiolytic effects of midazolam during anticipation to pain revealed using fMRI
    Richard G Wise
    Department of Clinical Neurology, Centre for Functional Magnetic Resonance Imaging of the Brain FMRIB, University of Oxford, John Radcliffe Hospital, OX3 9DU Oxford, UK
    Magn Reson Imaging 25:801-10. 2007
    ..We present a pharmacological functional magnetic resonance imaging (fMRI) study in which we investigate the selective modulation by midazolam of brain activity associated with anticipation to pain compared to pain itself...
  34. doi request reprint Psychophysical and functional imaging evidence supporting the presence of central sensitization in a cohort of osteoarthritis patients
    Stephen E Gwilym
    University of Oxford, Oxford, UK
    Arthritis Rheum 61:1226-34. 2009
    ..We aimed to identify the supraspinal influences that underlie these clinical manifestations that we consider indicative of possible central sensitization...
  35. doi request reprint Regions of interest analysis in pharmacological fMRI: how do the definition criteria influence the inferred result?
    Georgios D Mitsis
    Centre for Functional Magnetic Resonance Imaging of the Brain FMRIB, Department of Clinical Neurology, University of Oxford, Oxford, UK
    Neuroimage 40:121-32. 2008
    ..For these reasons, fROIs should be employed with caution when it is not possible to make clear anatomical prior hypotheses...
  36. pmc Widespread modulation of cerebral perfusion induced during and after transcranial direct current stimulation applied to the left dorsolateral prefrontal cortex
    Charlotte J Stagg
    Oxford Centre for Functional Magnetic Resonance Imaging of the Brain and Nuffield Division of Anaesthetics, Nuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom
    J Neurosci 33:11425-31. 2013
    ..2003). ..
  37. pmc Decoding the perception of pain from fMRI using multivariate pattern analysis
    Kay H Brodersen
    Centre for Functional Magnetic Resonance Imaging of the Brain FMRIB, Nuffield Department of Clinical Neurosciences, Nuffield Division Anaesthetics, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK
    Neuroimage 63:1162-70. 2012
    ..In addition to its utility in establishing structure-function mappings, our approach affords trial-by-trial predictions and thus represents a step towards the goal of establishing an objective neuronal marker of pain perception...
  38. pmc From nociception to pain perception: imaging the spinal and supraspinal pathways
    Jonathan Brooks
    Pain Imaging Neuroscience Group, Department of Human Anatomy and Genetics, University of Oxford, UK
    J Anat 207:19-33. 2005
    ..The ultimate goal of such research is to take these new techniques into the clinic, to investigate and provide new remedies for chronic pain sufferers...
  39. doi request reprint Anterior insula integrates information about salience into perceptual decisions about pain
    Katja Wiech
    Nuffield Department of Anaesthetics, University of Oxford, John Radcliffe Hospital, Oxford, UK
    J Neurosci 30:16324-31. 2010
    ..These findings provide evidence that the anterior insula and MCC as a "salience network" integrate information about the significance of an impending stimulation into perceptual decision-making in the context of pain...
  40. ncbi request reprint Combining fMRI with a pharmacokinetic model to determine which brain areas activated by painful stimulation are specifically modulated by remifentanil
    Richard G Wise
    Centre for Functional Magnetic Resonance Imaging of the Brain, Department of Clinical Neurology, University of Oxford, John Radcliffe Hospital, Oxford, OX3 9DU, United Kingdom
    Neuroimage 16:999-1014. 2002
    ..The method of examining time-dependent pharmacological modulation of specific brain activity may be generalized to other drugs that modulate brain activity other than that associated with pain...
  41. ncbi request reprint Dynamic forcing of end-tidal carbon dioxide and oxygen applied to functional magnetic resonance imaging
    Richard G Wise
    Centre for Functional Magnetic Resonance Imaging of the Brain, Department of Clinical Neurology, University of Oxford, John Radcliffe Hospital, Oxford, UK
    J Cereb Blood Flow Metab 27:1521-32. 2007
    ..The DEF system can provide flexible, convenient, and physiologically well-controlled respiratory challenges in the MRI environment for mapping dynamic responses of the cerebrovasculature...
  42. doi request reprint The effect of treatment expectation on drug efficacy: imaging the analgesic benefit of the opioid remifentanil
    Ulrike Bingel
    Oxford Centre for Functional MRI of the Brain, Nuffield Department of Clinical Neurosciences Division of Anaesthetics, University of Oxford, OX3 9DU Oxford, UK
    Sci Transl Med 3:70ra14. 2011
    ..We propose that it may be necessary to integrate patients' beliefs and expectations into drug treatment regimes alongside traditional considerations in order to optimize treatment outcomes...
  43. ncbi request reprint Pharmacological FMRI in the development of new analgesic compounds
    Petra Schweinhardt
    Pain Imaging Neuroscience Group, Department Physiology, Anatomy and Genetics, Oxford University, Oxford, UK
    NMR Biomed 19:702-11. 2006
    ..We are therefore optimistic that phFMRI will be used as a tool with high sensitivity and specificity for evaluating analgesic agents in early drug development and clinical studies...
  44. pmc Relief as a reward: hedonic and neural responses to safety from pain
    Siri Leknes
    Nuffield Division of Anaesthetics, Nuffield Department of Clinical Neurosciences, Centre for Functional Magnetic Resonance Imaging of the Brain FMRIB, University of Oxford, Oxford, Oxfordshire, United Kingdom
    PLoS ONE 6:e17870. 2011
    ..In conclusion, relief differs from appetitive rewards due to its reliance on negative expectations, the violation of which is reflected in relief-related accumbens activation...
  45. pmc Presence of mental imagery associated with chronic pelvic pain: a pilot study
    Chantal Berna
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK
    Pain Med 12:1086-93. 2011
    ..To ascertain whether a small sample of patients with chronic pelvic pain experienced any pain-related cognitions in the form of mental images...
  46. ncbi request reprint An fMRI study of cerebral processing of brush-evoked allodynia in neuropathic pain patients
    Petra Schweinhardt
    Department of Human Anatomy and Genetics, Oxford University, South Parks Road, Oxford OX1 1QX, UK
    Neuroimage 32:256-65. 2006
    ..Taken together, our data and the literature review suggest a functional segregation of anterior insular cortex...
  47. ncbi request reprint Brainstem functional imaging in humans
    Irene Tracey
    Human Anatomy and Genetics Department, Centre for Functional Magnetic Resonance Imaging of the Brain, Oxford University, South Parks Road, Oxford OX1 3QX, UK
    Suppl Clin Neurophysiol 58:52-67. 2006
  48. doi request reprint Thalamic atrophy associated with painful osteoarthritis of the hip is reversible after arthroplasty: a longitudinal voxel-based morphometric study
    Stephen E Gwilym
    University of Oxford, Oxford, UK
    Arthritis Rheum 62:2930-40. 2010
    ..From this previous work, it appears that chronic pain is associated with altered brain morphology. The present study was undertaken to assess these potential alterations in patients with painful hip osteoarthritis (OA)...
  49. doi request reprint Structural and functional bases of visuospatial associative memory in older adults
    Giovanna Zamboni
    Oxford Project to Investigate Memory and Ageing OPTIMA, Experimental Medicine Division of Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK
    Neurobiol Aging 34:961-72. 2013
    ....
  50. doi request reprint Neuroimaging as a tool for pain diagnosis and analgesic development
    Karolina Wartolowska
    Centre for Functional Magnetic Resonance Imaging of Brain, Department of Clinical Neurology, and Nuffield Department of Anaesthetics, University of Oxford, Oxford, England, OX3 9DU, United Kingdom
    Neurotherapeutics 6:755-60. 2009
    ..Moreover, neuroimaging shows promising results for analgesic drug development and in characterizing different types of pain, bringing us closer to development of mechanism-based diagnoses and treatments for the chronic pain patient...
  51. ncbi request reprint Imaging pain in patients: is it meaningful?
    Petra Schweinhardt
    Department of Physiology, Anatomy and Genetics, Oxford University, Oxford, Oxford, UK
    Curr Opin Neurol 19:392-400. 2006
    ..The timing is ideal to assess the utility of data generated from these studies...
  52. ncbi request reprint Quantitative assessment of the reproducibility of functional activation measured with BOLD and MR perfusion imaging: implications for clinical trial design
    Teddy Tjandra
    Oxford Centre for Functional Magnetic Resonance Imaging of the Brain, Department of Clinical Neurology, University of Oxford, England, UK
    Neuroimage 27:393-401. 2005
    ..In addition, the reduction of variance over time using CBF measurements (non-significant) suggests it could potentially provide a more useful approach when assessing longitudinal activation changes...
  53. ncbi request reprint Itch and motivation to scratch: an investigation of the central and peripheral correlates of allergen- and histamine-induced itch in humans
    Siri G Leknes
    Department of Physiology, Anatomy and Genetics, University of Oxford, South Parks Rd, Oxford OX1 3QX, UK
    J Neurophysiol 97:415-22. 2007
    ..g., addiction and obsessive compulsive disorder. The patterns of itch-induced activation reported here may help explain why chronic itch sufferers frequently self-harm through uncontrollable itch-scratch cycles...
  54. ncbi request reprint Using fMRI to quantify the time dependence of remifentanil analgesia in the human brain
    Richard G Wise
    Department of Clinical Neurology, Centre for Functional Magnetic Resonance Imaging of the Brain, University of Oxford, John Radcliffe Hospital, Oxford, UK
    Neuropsychopharmacology 29:626-35. 2004
    ..Comparison of the time course of regional brain activity with pain perception could reveal those regions engaged in drug-induced analgesia...
  55. ncbi request reprint Imaging how attention modulates pain in humans using functional MRI
    Susanna J Bantick
    Oxford University Department of Clinical Neurology, Centre for Functional Magnetic Resonance Imaging of the Brain, John Radcliffe Hospital, Headington, Oxford, UK
    Brain 125:310-9. 2002
    ..In contrast, many areas of the pain matrix (i.e. thalamus, insula, cognitive division of the ACC) displayed reduced activation, supporting the behavioural results of reduced pain perception...
  56. doi request reprint Dysmenorrhoea is associated with central changes in otherwise healthy women
    Katy Vincent
    Centre for Functional Magnetic Resonance Imaging of the Brain, Nuffield Department of Clinical Neurosciences, Nuffield Division Anaesthetics, University of Oxford, UK
    Pain 152:1966-75. 2011
    ..These findings indicate the potential importance of early and adequate treatment of dysmenorrhoea...
  57. ncbi request reprint A comparison of visceral and somatic pain processing in the human brainstem using functional magnetic resonance imaging
    Paul Dunckley
    Department of Human Anatomy and Genetics, University of Oxford, Oxford OX1 3QX, United Kingdom
    J Neurosci 25:7333-41. 2005
    ..05, Pearson's r, two-tailed) but not somatic stimulation. We propose that the differences in NCF and right PAG activation observed may represent a greater nocifensive response and greater emotive salience of visceral over somatic pain...
  58. ncbi request reprint Imaging CNS modulation of pain in humans
    Ulrike Bingel
    Department of Neurology, NeuroImage Nord, University Medical Center Hamburg Eppendorf, Germany
    Physiology (Bethesda) 23:371-80. 2008
    ..Research on the involved circuitry and implemented mechanisms is a major focus of contemporary neuroscientific research in the field of pain and should provide new insights to prevent and treat chronic pain states...
  59. ncbi request reprint Physiological noise modelling for spinal functional magnetic resonance imaging studies
    Jonathan C W Brooks
    PAIN Group, Department of Physiology Anatomy and Genetics, Le Gros Clark Building, South Parks Road, Oxford OX1 3QX, UK
    Neuroimage 39:680-92. 2008
    ....
  60. ncbi request reprint Adelta nociceptor response to laser stimuli: selective effect of stimulus duration on skin temperature, brain potentials and pain perception
    G D Iannetti
    Department of Human Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, UK
    Clin Neurophysiol 115:2629-37. 2004
    ..To disclose a possible effect of duration of pulsed laser heat stimuli on Adelta nociceptor responses, skin temperature profiles, brain evoked potentials and pain perception...
  61. ncbi request reprint An in vivo and in vitro H-magnetic resonance spectroscopy study of mdx mouse brain: abnormal development or neural necrosis?
    I Tracey
    MRC Biochemical and Clinical Magnetic Resonance Unit, Department of Biochemistry, Oxford University, UK
    J Neurol Sci 141:13-8. 1996
    ..In contrast, choline compounds and myo-inositol levels were increased, indicative of gliosis or developmental abnormalities in dystrophic brain...
  62. ncbi request reprint Somatotopic organisation of the human insula to painful heat studied with high resolution functional imaging
    J C W Brooks
    Department of Human Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, UK
    Neuroimage 27:201-9. 2005
    ..037). Based on single subject analyses, the average standard space (MNI) coordinates for face, hand and foot activity were (-40,-16,11), (-40,-19,14) and (-35,-21,11) respectively...
  63. ncbi request reprint Dissociating pain from its anticipation in the human brain
    A Ploghaus
    Centre for Functional Magnetic Resonance Imaging of the Brain, Department of Clinical Neurology, University of Oxford, Oxford OX3 9DU, UK
    Science 284:1979-81. 1999
    ..Selective manipulations of activity at these sites may offer therapeutic possibilities for treating chronic pain...
  64. ncbi request reprint Operculoinsular cortex encodes pain intensity at the earliest stages of cortical processing as indicated by amplitude of laser-evoked potentials in humans
    G D Iannetti
    Department of Human Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, UK
    Neuroscience 131:199-208. 2005
    ....
  65. pmc Importance of anti- and pro-nociceptive mechanisms in human disease
    I Tracey
    Pain Imaging Neuroscience PaIN Group, Human Anatomy and Genetics Department, FMRIB Centre, Oxford University, South Parks Rd, Oxford OX1 3QX, UK
    Gut 53:1553-5. 2004
  66. ncbi request reprint Cerebellar responses during anticipation of noxious stimuli in subjects recovered from depression. Functional magnetic resonance imaging study
    K A Smith
    University Department of Psychiatry, Warneford Hospital, Oxford, UK
    Br J Psychiatry 181:411-5. 2002
    ..Subjects recovered from depression have a substantial risk for recurrence of depression, suggesting persistent abnormalities in brain activity...
  67. ncbi request reprint Exacerbation of pain by anxiety is associated with activity in a hippocampal network
    A Ploghaus
    Oxford Centre for Functional Magnetic Resonance Imaging of the Brain, Department of Clinical Neurology, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom
    J Neurosci 21:9896-903. 2001
    ..It supports the proposal that during anxiety, the hippocampal formation amplifies aversive events to prime behavioral responses that are adaptive to the worst possible outcome...
  68. pmc Learning about pain: the neural substrate of the prediction error for aversive events
    A Ploghaus
    Centre for Functional MRI of the Brain, Department of Clinical Neurology, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, United Kingdom
    Proc Natl Acad Sci U S A 97:9281-6. 2000
    ..Searching for interventions to specifically modulate activation of these brain regions therefore offers an approach to identifying new treatments for chronic pain, which often has a substantial associative learning component...
  69. pmc Similar nociceptive afferents mediate psychophysical and electrophysiological responses to heat stimulation of glabrous and hairy skin in humans
    G D Iannetti
    Department of Physiology, Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, UK
    J Physiol 577:235-48. 2006
    ..e. CO(2) laser) as stimulation procedure...
  70. pmc Blood oxygenation level dependent functional magnetic resonance imaging: current and potential uses in obstetrics and gynaecology
    K Vincent
    Nuffield Department of Obstetrics and Gynaecology, Oxford University, John Radcliffe Hospital, Headley Way, Oxford, OX3 9DU, UK
    BJOG 116:240-6. 2009
    ..Finally we review some of the more novel applications of the technique, such as imaging of pelvic floor function and the effects of hypoxia on the fetus...
  71. doi request reprint Remembering John Newsom-Davis' contribution to human imaging in Oxford
    P M Matthews
    Centre for Functional MRI of the Brain and Department of Clinical Neurology, John Radcliffe Hospital, University of Oxford, United Kingdom
    J Neuroimmunol 201:250-4. 2008
    ....
  72. pmc Pharmacological modulation of pain-related brain activity during normal and central sensitization states in humans
    G D Iannetti
    Department of Human Anatomy and Genetics, and Centre for Functional Magnetic Resonance Imaging of the Brain, University of Oxford, UK
    Proc Natl Acad Sci U S A 102:18195-200. 2005
    ....
  73. ncbi request reprint Simultaneous recording of laser-evoked brain potentials and continuous, high-field functional magnetic resonance imaging in humans
    G D Iannetti
    Department of Human Anatomy and Genetics, University of Oxford, Oxford, UK
    Neuroimage 28:708-19. 2005
    ..Truly simultaneous recording of LEPs and fMRI is still desirable in specific experimental conditions, such as single-trial, learning, and pharmacological studies...
  74. doi request reprint Structural changes of the brain in rheumatoid arthritis
    Karolina Wartolowska
    Oxford Centre for Functional Magnetic Resonance Imaging of the Brain and University of Oxford, Oxford, UK
    Arthritis Rheum 64:371-9. 2012
    ..To investigate whether structural changes are present in the cortical and subcortical gray matter of the brains of patients with rheumatoid arthritis (RA)...
  75. doi request reprint Assessment of physiological noise modelling methods for functional imaging of the spinal cord
    Yazhuo Kong
    Centre for Functional Magnetic Resonance Imaging of the Brain FMRIB, University of Oxford, Oxford, UK
    Neuroimage 60:1538-49. 2012
    ..Pre-whitening was found to reduce non-white noise, which was not accounted for by physiological noise correction, and decrease false positive detection rates...
  76. ncbi request reprint An investigation to dissociate the analgesic and anesthetic properties of ketamine using functional magnetic resonance imaging
    Richard Rogers
    Nuffield Department of Anesthetics, John Radcliffe Hospital, Oxford, Oxfordshire, OX3 9DU, United Kingdom
    Anesthesiology 100:292-301. 2004
    ..The aim of this study was to determine whether the analgesic effects of ketamine could be imaged...
  77. doi request reprint The influence of negative emotions on pain: behavioral effects and neural mechanisms
    Katja Wiech
    Nuffield Department of Anaesthetics, University of Oxford, John Radcliffe Hospital, Headley Way, Oxford OX3 9DU, UK
    Neuroimage 47:987-94. 2009
    ..We discuss possible neural mechanisms underlying this modulatory influence focusing on the periaqueductal grey (PAG), amygdala, anterior cingulate cortex (ACC) and anterior insula as key players in both, pain and affective processing...
  78. pmc Neural correlates of an injury-free model of central sensitization induced by opioid withdrawal in humans
    Vishvarani Wanigasekera
    Centre for Functional Magnetic Resonance Imaging of the Brain, Nuffield Department of Clinical Neurosciences, Division of Anaesthetics, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DU, United Kingdom
    J Neurosci 31:2835-42. 2011
    ....
  79. ncbi request reprint Nociceptive processing in the human brain
    Irene Tracey
    Department Human Anatomy and Genetics, Centre for Functional Magnetic Resonance Imaging of the Brain, Oxford University, Oxford OX1 3QX, England, UK
    Curr Opin Neurobiol 15:478-87. 2005
    ..The result has produced a dramatic shift in our thinking about the neural circuitry involved in nociceptive processing, revealing that pain is much more than a submodality of the sense of touch...
  80. ncbi request reprint An fMRI study measuring analgesia enhanced by religion as a belief system
    Katja Wiech
    Nuffield Department of Anaesthetics, University of Oxford, John Radcliffe Hospital, Oxford, UK
    Pain 139:467-76. 2008
    ..We suggest that religious belief might provide a framework that allows individuals to engage known pain-regulatory brain processes...
  81. doi request reprint Investigation into the neural correlates of emotional augmentation of clinical pain
    Petra Schweinhardt
    Centre for Functional Magnetic Resonance Imaging, Department of Clinical Neurology, John Radcliffe Hospital, Oxford, OX3 9DU, UK
    Neuroimage 40:759-66. 2008
    ....
  82. ncbi request reprint Resting fluctuations in arterial carbon dioxide induce significant low frequency variations in BOLD signal
    Richard G Wise
    Centre for Functional Magnetic Resonance Imaging of the Brain, Department of Clinical Neurology, John Radcliffe Hospital, University of Oxford, Oxford, UK
    Neuroimage 21:1652-64. 2004
    ..These fluctuations are a source of physiological noise and a potentially important confounding factor in fMRI paradigms that modify breathing. However, they can also be used for mapping regional vascular responsiveness to CO(2)...
  83. ncbi request reprint A 31P-NMR study of muscle exercise metabolism in mdx mice: evidence for abnormal pH regulation
    J F Dunn
    Dept of Biochemistry, University of Oxford, UK
    J Neurol Sci 113:108-13. 1992
    ..This provides more evidence of impaired ionic regulation in dystrophic muscle and could be used as an index for the evaluation in vivo of therapeutic interventions such as myoblast transfer or gene replacement therapy...
  84. ncbi request reprint A role for the brainstem in central sensitisation in humans. Evidence from functional magnetic resonance imaging
    L Zambreanu
    Pain Imaging Neuroscience PaIN Group, Department of Human Anatomy and Genetics, Oxford University, South Parks Road, Oxford OX1 3QX, UK
    Pain 114:397-407. 2005
    ..These results suggest that structures in the mesencephalic reticular formation, possibly the NCF and PAG, are involved in central sensitisation in humans...
  85. ncbi request reprint The role of fMRI in drug discovery
    Richard G Wise
    Pain Imaging Neuroscience Group, Department of Human Anatomy and Genetics, University of Oxford, South Parks Road, Oxford, UK
    J Magn Reson Imaging 23:862-76. 2006
    ..In future, pharmacological fMRI is likely to extend to examinations of the spinal cord and into pharmacogenetics to relate genetic polymorphisms to differential responses of the brain to drugs...
  86. doi request reprint A common neurobiology for pain and pleasure
    Siri Leknes
    Oxford Centre for Functional MRI of the Brain, Department of Clinical Neurology, Oxford University, John Radcliffe Hospital, Oxford, OX3 9DU, UK
    Nat Rev Neurosci 9:314-20. 2008
    ..Understanding the mutually inhibitory effects that pain and reward processing have on each other, and the neural mechanisms that underpin such modulation, is important for alleviating unnecessary suffering and improving well-being...
  87. ncbi request reprint Brain metabolism is abnormal in the mdx model of Duchenne muscular dystrophy
    I Tracey
    Department of Biochemistry, Oxford University, UK
    Brain 119:1039-44. 1996
    ..It is proposed that these biochemical changes may be a factor in the reduced cognitive capacity of mdx mice and some DMD children...
  88. ncbi request reprint Counter-stimulatory effects on pain perception and processing are significantly altered by attention: an fMRI study
    S E Longe
    Centre for Functional Magnetic Resonance Imaging of the Brain (FMRIB, Dept of Clinical Neurology, University of Oxford, John Radcliffe Hospital, Headley Way, Oxford, OX3 9DU, UK
    Neuroreport 12:2021-5. 2001
    ..These results suggest attention plays an important part in the pain relief experienced from counter-stimulation...
  89. ncbi request reprint Attentional modulation of visceral and somatic pain
    P Dunckley
    Department of Physiology, Anatomy and Genetics, Oxford, UK
    Neurogastroenterol Motil 19:569-77. 2007
    ..These results suggest that pain intensity perception during attentional modulation is reflected in the primary somatosensory cortex (visceral pain) and aIns cortex activity (somatic pain)...
  90. pmc Imaging the neural correlates of neuropathic pain and pleasurable relief associated with inherited erythromelalgia in a single subject with quantitative arterial spin labelling
    Andrew R Segerdahl
    Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, Oxfordshire, UK
    Pain 153:1122-7. 2012
    ..This combined approach allowed us to confirm the presence of a temperature-sensitive channelopathy of peripheral neurons and to investigate the neural correlates of tonic neuropathic pain and relief in a single subject...
  91. doi request reprint Sex hormones and pain: the evidence from functional imaging
    Katy Vincent
    Functional Magnetic Resonance Imaging of the Brain Centre, Department of Clinical Neurology, University of Oxford, John Radcliffe Hospital, Headley Way, Oxford, OX3 9DU, UK
    Curr Pain Headache Rep 14:396-403. 2010
    ..Finally, we conclude by considering how results of studies imaging the influence of sex hormones in related areas such as emotion and cognition also may inform our understanding of this complex area...
  92. ncbi request reprint A 31P-magnetic resonance spectroscopy and biochemical study of the mo(vbr) mouse: potential model for the mitochondrial encephalomyopathies
    I Tracey
    Department of Biochemistry, Oxford University, United Kingdom
    Muscle Nerve 20:1352-9. 1997
    ..The PCr recovery rate, measured by 31P-MRS, was sensitive to the muscle abnormality. This strain is best described as having chronic mitochondrial dysfunction...
  93. ncbi request reprint Lateralisation of nociceptive processing in the human brain: a functional magnetic resonance imaging study
    Paula D Youell
    Human Pain Research Group, University of Manchester Rheumatic Diseases Centre, Hope Hospital, Salford M6 8HD, UK
    Neuroimage 23:1068-77. 2004
    ....
  94. ncbi request reprint Functional connectivity and pain: how effectively connected is your brain?
    Irene Tracey
    Pain 116:173-4. 2005
  95. ncbi request reprint Functional responses in the human spinal cord during willed motor actions: evidence for side- and rate-dependent activity
    Marta Maieron
    Dipartimento di Scienze Biomediche, Universita di Modena e Reggio Emilia, 41100 Modena, Italy
    J Neurosci 27:4182-90. 2007
    ....
  96. ncbi request reprint Evidence for asymmetric frontal-lobe involvement in episodic memory from functional magnetic resonance imaging and patients with unilateral frontal-lobe excisions
    Andy C H Lee
    MRC Cognition and Brain Sciences Unit, 15 Chaucer Road, CB2 2EF, Cambridge, UK
    Neuropsychologia 40:2420-37. 2002
    ..This result suggests that the memory-related asymmetries observed during functional neuroimaging studies may not be critical for task performance...