Paul A Townsend

Summary

Affiliation: University College London
Country: UK

Publications

  1. ncbi BAG-1 proteins protect cardiac myocytes from simulated ischemia/reperfusion-induced apoptosis via an alternate mechanism of cell survival independent of the proteasome
    Paul A Townsend
    Medical Molecular Biology Unit, Institute of Child Health, University College London, London WC1N 1EH, United Kingdom
    J Biol Chem 279:20723-8. 2004
  2. ncbi BAG-1: a multi-functional pro-survival molecule
    Paul A Townsend
    Medical Molecular Biology Unit, Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, UK
    Int J Biochem Cell Biol 37:251-9. 2005
  3. pmc New targets of urocortin-mediated cardioprotection
    Sean P Barry
    Medical Molecular Biology Unit, Institute of Child Health, University College London, London, WC1N 1EH, UK
    J Mol Endocrinol 45:69-85. 2010
  4. ncbi Epigallocatechin-3-gallate inhibits STAT-1 activation and protects cardiac myocytes from ischemia/reperfusion-induced apoptosis
    Paul A Townsend
    Medical Molecular Biology Unit, Institute of Child Health, University College London, London, England
    FASEB J 18:1621-3. 2004
  5. ncbi STAT1 regulates p73-mediated Bax gene expression
    Surinder M Soond
    Medical Molecular Biology Unit, Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, UK
    FEBS Lett 581:1217-26. 2007
  6. ncbi STAT-1 facilitates the ATM activated checkpoint pathway following DNA damage
    Paul A Townsend
    Medical Molecular Biology Unit, Institute of Child Health, University College London, 30 Guilford Street, London, WC1N 1EH, UK
    J Cell Sci 118:1629-39. 2005
  7. pmc STAT3 modulates the DNA damage response pathway
    Sean P Barry
    Medical Molecular Biology Unit, Institute of Child Health, University College London, London, UK
    Int J Exp Pathol 91:506-14. 2010
  8. ncbi STAT-1 interacts with p53 to enhance DNA damage-induced apoptosis
    Paul A Townsend
    Medical Molecular Biology Unit, Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, United Kingdom
    J Biol Chem 279:5811-20. 2004
  9. ncbi Free radical scavenging inhibits STAT phosphorylation following in vivo ischemia/reperfusion injury
    James McCormick
    Department of Medical Molecular Biology, The Institute of Child Health, University College London, 30 Guilford St, London, WC1N 1EH, UK
    FASEB J 20:2115-7. 2006
  10. ncbi Urocortin inhibits Beclin1-mediated autophagic cell death in cardiac myocytes exposed to ischaemia/reperfusion injury
    Lauren Valentim
    Medical Molecular Biology Unit, Institute of Child Health, University College London, 30 Guilford Street, London, WC1N 1EH, UK
    J Mol Cell Cardiol 40:846-52. 2006

Collaborators

Detail Information

Publications31

  1. ncbi BAG-1 proteins protect cardiac myocytes from simulated ischemia/reperfusion-induced apoptosis via an alternate mechanism of cell survival independent of the proteasome
    Paul A Townsend
    Medical Molecular Biology Unit, Institute of Child Health, University College London, London WC1N 1EH, United Kingdom
    J Biol Chem 279:20723-8. 2004
    ..Our studies demonstrate that BAG-1 can influence cellular response to stress by multiple mechanisms, potentially influenced by the cell type and nature of the stress signal...
  2. ncbi BAG-1: a multi-functional pro-survival molecule
    Paul A Townsend
    Medical Molecular Biology Unit, Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, UK
    Int J Biochem Cell Biol 37:251-9. 2005
    ....
  3. pmc New targets of urocortin-mediated cardioprotection
    Sean P Barry
    Medical Molecular Biology Unit, Institute of Child Health, University College London, London, WC1N 1EH, UK
    J Mol Endocrinol 45:69-85. 2010
    ..These data uncover novel gene expression changes induced by UCNs, which will serve as a platform to further understand their mechanism of action in normal physiology and cardioprotection...
  4. ncbi Epigallocatechin-3-gallate inhibits STAT-1 activation and protects cardiac myocytes from ischemia/reperfusion-induced apoptosis
    Paul A Townsend
    Medical Molecular Biology Unit, Institute of Child Health, University College London, London, England
    FASEB J 18:1621-3. 2004
    ....
  5. ncbi STAT1 regulates p73-mediated Bax gene expression
    Surinder M Soond
    Medical Molecular Biology Unit, Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, UK
    FEBS Lett 581:1217-26. 2007
    ..This study presents the first report physically linking STAT1 and TA-p73 signalling and highlights the modulation of the Bax promoter in the context of IFN-gamma stimulation...
  6. ncbi STAT-1 facilitates the ATM activated checkpoint pathway following DNA damage
    Paul A Townsend
    Medical Molecular Biology Unit, Institute of Child Health, University College London, 30 Guilford Street, London, WC1N 1EH, UK
    J Cell Sci 118:1629-39. 2005
    ..These results imply that STAT-1 plays a crucial role in the DNA-damage-response by regulating the expression of 53BP1 and MDC1, factors known to be important for mediating ATM-dependent checkpoint pathways...
  7. pmc STAT3 modulates the DNA damage response pathway
    Sean P Barry
    Medical Molecular Biology Unit, Institute of Child Health, University College London, London, UK
    Int J Exp Pathol 91:506-14. 2010
    ..These findings demonstrate that STAT3 is necessary for efficient repair of damaged DNA, partly by modulating the ATM-Chk2 and ATR-Chk1 pathways...
  8. ncbi STAT-1 interacts with p53 to enhance DNA damage-induced apoptosis
    Paul A Townsend
    Medical Molecular Biology Unit, Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, United Kingdom
    J Biol Chem 279:5811-20. 2004
    ..Therefore, in addition to negatively regulating Mdm2, STAT-1 also acts as a coactivator for p53. Hence STAT-1 is another member of a growing family of protein partners able to modulate the p53-activated apoptotic pathway...
  9. ncbi Free radical scavenging inhibits STAT phosphorylation following in vivo ischemia/reperfusion injury
    James McCormick
    Department of Medical Molecular Biology, The Institute of Child Health, University College London, 30 Guilford St, London, WC1N 1EH, UK
    FASEB J 20:2115-7. 2006
    ..This study demonstrates that careful dissection of the molecular mechanisms that underpin I/R injury may reveal cardioprotective targets for future therapy...
  10. ncbi Urocortin inhibits Beclin1-mediated autophagic cell death in cardiac myocytes exposed to ischaemia/reperfusion injury
    Lauren Valentim
    Medical Molecular Biology Unit, Institute of Child Health, University College London, 30 Guilford Street, London, WC1N 1EH, UK
    J Mol Cell Cardiol 40:846-52. 2006
    ..The inhibition of autophagy by urocortin is mediated in part by inhibition of Beclin1 expression, an effect which is mediated by activation of the PI3 kinase/Akt pathway but which does not involve activation of p42/p44 MAPK...
  11. pmc ERK and the F-box protein betaTRCP target STAT1 for degradation
    Surinder M Soond
    Medical Molecular Biology Unit, Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, United Kingdom
    J Biol Chem 283:16077-83. 2008
    ..These data suggest that constitutively active ERK may inappropriately degrade STAT1, with loss of its pro-apoptotic and tumor suppressor functions...
  12. pmc STAT3 deletion sensitizes cells to oxidative stress
    Sean P Barry
    Medical Molecular Biology Unit, Institute of Child Health, University College London, 30 Guilford Street, London WC1N1EH, UK
    Biochem Biophys Res Commun 385:324-9. 2009
    ..Depletion of STAT3 sensitized cells to apoptotic cell death following oxidative stress. These results provide direct evidence for the role of STAT3 as a cytoprotective transcription factor in cells exposed to oxidative stress...
  13. doi Transgenic overexpression of HSP56 does not result in cardiac hypertrophy nor protect from ischaemia/reperfusion injury
    Christopher J Carroll
    Medical Molecular Biology Unit, Institute of Child Health, University College London, London WC1N 1EH, UK
    Int J Biochem Cell Biol 43:74-9. 2011
    ..These observations now suggest a more intricate HSP56-Sp. Cardiophenotype that requires further studies to determine if HSP56 is necessary in mediating hypertrophy induced by other myocardial stimuli...
  14. ncbi The transcriptional coactivator p300 plays a critical role in the hypertrophic and protective pathways induced by phenylephrine in cardiac cells but is specific to the hypertrophic effect of urocortin
    Sean M Davidson
    Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, UK
    Chembiochem 6:162-70. 2005
    ....
  15. ncbi The cardioprotective effect of urocortin during ischaemia/reperfusion involves the prevention of mitochondrial damage
    Kevin M Lawrence
    Medical Molecular Biology Unit, Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, UK
    Biochem Biophys Res Commun 321:479-86. 2004
    ..These proteins may interact at the mitochondria to produce the protective effect...
  16. ncbi Hypertrophic effects of urocortin homologous peptides are mediated via activation of the Akt pathway
    Anastasios Chanalaris
    Medical Molecular Biology Unit, Institute of Child Health, University College London, London WC1N 1EH, UK
    Biochem Biophys Res Commun 328:442-8. 2005
    ..In addition, we provide a mechanism of action for the three peptides and show that Akt phosphorylation is important for their hypertrophic action, whereas MAPK p42/44 is not involved in this effect...
  17. ncbi The carboxyl-terminal activation domain of the STAT-1 transcription factor enhances ischemia/reperfusion-induced apoptosis in cardiac myocytes
    Anastasis Stephanou
    Medical Molecular Biology Unit, Institute of Child Health, University College London, London WC1N 1EH, UK
    FASEB J 16:1841-3. 2002
    ..These studies demonstrate that the C-terminal transactivation domain of STAT-1 is necessary and sufficient for I/R injury-induced apoptosis in cardiac myocytes...
  18. ncbi Role of the JAK-STAT pathway in myocardial injury
    Sean P Barry
    Medical Molecular Biology Unit, The Institute of Child Health, University College London, 30 Guilford Street, London, UK
    Trends Mol Med 13:82-9. 2007
    ....
  19. doi Molecular regulation of cardiac hypertrophy
    Sean P Barry
    Medical Molecular Biology Unit, Institute of Child Health, University College London, 30 Guilford Street, London WC1N IEH, United Kingdom
    Int J Biochem Cell Biol 40:2023-39. 2008
    ..The challenge will be translating this knowledge into potential pharmacological therapies for the treatment of cardiac pathologies...
  20. doi The powerful cardioprotective effects of urocortin and the corticotropin releasing hormone (CRH) family
    Sean M Davidson
    The Hatter Cardiovascular Institute, University College London Hospital and Medical School, London, UK
    Biochem Pharmacol 77:141-50. 2009
    ....
  21. doi Cardiac release of urocortin precedes the occurrence of irreversible myocardial damage in the rat heart exposed to ischemia/reperfusion injury
    Richard A Knight
    Medical Molecular Biology Unit, Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, United Kingdom
    FEBS Lett 582:984-90. 2008
    ..Hence, since cardiac release of urocortin, unlike that of conventional biomarkers, occurs before and apart from cell death, urocortin levels may be clinically useful in the diagnosis of sublethal myocardial ischemia...
  22. ncbi BAG-1: a multifunctional regulator of cell growth and survival
    Paul A Townsend
    Cancer Research UK Oncology Unit, Cancer Sciences Division, School of Medicine, University of Southampton, Southampton SO16 6YD, UK
    Biochim Biophys Acta 1603:83-98. 2003
    ..This review summarises current understanding of molecular mechanisms of BAG-1 expression and function...
  23. ncbi The retinoblastoma protein interacts with Bag-1 in human colonic adenoma and carcinoma derived cell lines
    Nathalie J Arhel
    Cancer Research UK Colorectal Tumour Biology Research Group, Department of Pathology and Microbiology, University of Bristol, School of Medical Sciences, Bristol BS8 1TD, United Kingdom
    Int J Cancer 106:364-71. 2003
    ..Our work establishes that the Rb protein interacts with the Bag-1 apoptotic regulator protein, and introduces a novel function for Rb, involving modulation of the subcellular localisation of Bag-1 in human colonic epithelial cells...
  24. ncbi BAG-1 prevents stress-induced long-term growth inhibition in breast cancer cells via a chaperone-dependent pathway
    Paul A Townsend
    Cancer Research UK Oncology Unit, Cancer Sciences Division, University of Southampton School of Medicine, Southampton General Hospital, Southampton S016 6YD, United Kingdom
    Cancer Res 63:4150-7. 2003
    ..Targeting the interaction of BAG-1 with chaperones is an attractive strategy to counter the biological effects of BAG-1...
  25. doi Amino acid supplementation differentially modulates STAT1 and STAT3 activation in the myocardium exposed to ischemia/reperfusion injury
    Tiziano M Scarabelli
    Center for Heart and Vessel Preclinical Studies, St John Hospital and Medical Center, Wayne State University School of Medicine, Detroit, Michigan, USA
    Am J Cardiol 101:63E-68E. 2008
    ....
  26. pmc PIAS-1 is a checkpoint regulator which affects exit from G1 and G2 by sumoylation of p73
    Eliana Munarriz
    Medical Research Council, Toxicology Unit, Hodgkin Building, Leicester University, Lancaster Road, P O Box 138, Leicester LE1 9HN, United Kingdom
    Mol Cell Biol 24:10593-610. 2004
    ..These data suggest that PIAS-1, acting partly through binding and sumoylation of p73, is an important component of the cell cycle machinery...
  27. ncbi Bcl-2-associated athanogene-1 (BAG-1): a transcriptional regulator mediating chondrocyte survival and differentiation during endochondral ossification
    Rahul S Tare
    Bone and Joint Research Group, Centre for Human Development, Stem Cells and Regeneration, Institute of Developmental Sciences, University of Southampton, Southampton General Hospital, Tremona Road, Southampton, SO16 6YD, UK
    Bone 42:113-28. 2008
    ..Modulation of Bag-1 expression can therefore mediate chondrocyte differentiation and turnover, and offer further insight into the molecular regulation of endochondral ossification...
  28. pmc Urocortin prevents mitochondrial permeability transition in response to reperfusion injury indirectly by reducing oxidative stress
    Paul A Townsend
    Human Genetics Division, University of Southampton, Southampton, UK
    Am J Physiol Heart Circ Physiol 293:H928-38. 2007
    ..Our data suggest that acute UCN treatment protects the heart by inhibiting MPTP opening. However, the mechanism appears to be indirect, involving a PKC-mediated reduction in oxidative stress...
  29. ncbi BAG-1 in carcinogenesis
    Adam Sharp
    Cancer Research UK Oncology Unit, The Somers Cancer Research Building, University of Southampton School of Medicine, Southampton General Hospital, Southampton, S016 6YD, UK
    Expert Rev Mol Med 6:1-15. 2004
    ..This review describes the structure and function of BAG-1 isoforms and the potential clinical implications of their expression in tumour cells...
  30. ncbi The nuclear BAG-1 isoform, BAG-1L, enhances oestrogen-dependent transcription
    Ramsey I Cutress
    Cancer Research UK Oncology Unit, Cancer Sciences Division, School of Medicine, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK
    Oncogene 22:4973-82. 2003
    ..These data suggest that BAG-1L is an important determinant of ER function in vitro and in human breast cancer...
  31. pmc SELDI-TOF proteomic profiling of breast carcinomas identifies clinicopathologically relevant groups of patients similar to previously defined clusters from cDNA expression
    Bashar A Zeidan
    Breast Cancer Res 10:107. 2008
    ....