Cathy Tournier

Summary

Affiliation: University of Manchester
Country: UK

Publications

  1. ncbi request reprint Impaired JNK Signaling Cooperates with KrasG12D Expression to Accelerate Pancreatic Ductal Adenocarcinoma
    Clare C Davies
    Authors Affiliations Faculty of Life Sciences and Department of Histopathology Medical School, University of Manchester, Manchester Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, United Kingdom and Howard Hughes Medical Institute and Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts
    Cancer Res 74:3344-56. 2014
  2. pmc Regulation of neuronal survival by the extracellular signal-regulated protein kinase 5
    K G Finegan
    Faculty of Life Sciences, University of Manchester, Manchester, UK
    Cell Death Differ 16:674-83. 2009
  3. ncbi request reprint Regulation of cellular functions by the ERK5 signalling pathway
    Xin Wang
    Faculty of Life Sciences, University of Manchester, Michael Smith Building, Oxford Road, Manchester M13 9PT, UK
    Cell Signal 18:753-60. 2006
  4. pmc A novel mitogen-activated protein kinase docking site in the N terminus of MEK5alpha organizes the components of the extracellular signal-regulated kinase 5 signaling pathway
    Jan Seyfried
    Faculty of Life Sciences, University of Manchester, Michael Smith Building, Oxford Road, Manchester M13 9PT, United Kingdom
    Mol Cell Biol 25:9820-8. 2005
  5. ncbi request reprint The regulation of Bax by c-Jun N-terminal protein kinase (JNK) is a prerequisite to the mitochondrial-induced apoptotic pathway
    Emmanouil S Papadakis
    Faculty of Life Sciences, University of Manchester, Michael Smith Building, Oxford Road, Manchester M13 9PT, UK
    FEBS Lett 580:1320-6. 2006
  6. pmc Targeted deletion of the mitogen-activated protein kinase kinase 4 gene in the nervous system causes severe brain developmental defects and premature death
    Xin Wang
    Faculty of Life Sciences, Wellcome Trust Center for Cell Matrix Research, University of Manchester, Michael Smith Building, Oxford Road, Manchester M13 9PT, United Kingdom
    Mol Cell Biol 27:7935-46. 2007
  7. pmc Selective regulation of c-jun gene expression by mitogen-activated protein kinases via the 12-o-tetradecanoylphorbol-13-acetate- responsive element and myocyte enhancer factor 2 binding sites
    Midori Kayahara
    Faculty of Life Sciences, University of Manchester, The Michael Smith Building, Oxford Road, Manchester M13 9PT, United Kingdom
    Mol Cell Biol 25:3784-92. 2005
  8. ncbi request reprint Physiological roles of MKK4 and MKK7: insights from animal models
    Xin Wang
    Faculty of Life Sciences, University of Manchester, Michael Smith Building, Oxford Road, Manchester M13 9PT, UK
    Biochim Biophys Acta 1773:1349-57. 2007
  9. pmc JNK and PTEN cooperatively control the development of invasive adenocarcinoma of the prostate
    Anette Hübner
    University of Massachusetts Medical School, Worcester, MA 01605, USA
    Proc Natl Acad Sci U S A 109:12046-51. 2012
  10. doi request reprint The loss of c-Jun N-terminal protein kinase activity prevents the amyloidogenic cleavage of amyloid precursor protein and the formation of amyloid plaques in vivo
    Sonia Mazzitelli
    Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, United Kingdom
    J Neurosci 31:16969-76. 2011

Collaborators

Detail Information

Publications18

  1. ncbi request reprint Impaired JNK Signaling Cooperates with KrasG12D Expression to Accelerate Pancreatic Ductal Adenocarcinoma
    Clare C Davies
    Authors Affiliations Faculty of Life Sciences and Department of Histopathology Medical School, University of Manchester, Manchester Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, United Kingdom and Howard Hughes Medical Institute and Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts
    Cancer Res 74:3344-56. 2014
    ..Cancer Res; 74(12); 3344-56. ©2014 AACR. ..
  2. pmc Regulation of neuronal survival by the extracellular signal-regulated protein kinase 5
    K G Finegan
    Faculty of Life Sciences, University of Manchester, Manchester, UK
    Cell Death Differ 16:674-83. 2009
    ..Together these findings reveal a novel signaling mechanism that promotes neuronal survival during the development of the PNS...
  3. ncbi request reprint Regulation of cellular functions by the ERK5 signalling pathway
    Xin Wang
    Faculty of Life Sciences, University of Manchester, Michael Smith Building, Oxford Road, Manchester M13 9PT, UK
    Cell Signal 18:753-60. 2006
    ..The analysis of genetically modified mice in which the erk5 gene can be specifically deleted in certain tissues is shedding light into the physiological function of the ERK5 pathway during development and pathogenesis...
  4. pmc A novel mitogen-activated protein kinase docking site in the N terminus of MEK5alpha organizes the components of the extracellular signal-regulated kinase 5 signaling pathway
    Jan Seyfried
    Faculty of Life Sciences, University of Manchester, Michael Smith Building, Oxford Road, Manchester M13 9PT, United Kingdom
    Mol Cell Biol 25:9820-8. 2005
    ..Altogether these results establish that the N terminus of MEK5alpha is critical for the specific organization of the components of the ERK5 signaling pathway...
  5. ncbi request reprint The regulation of Bax by c-Jun N-terminal protein kinase (JNK) is a prerequisite to the mitochondrial-induced apoptotic pathway
    Emmanouil S Papadakis
    Faculty of Life Sciences, University of Manchester, Michael Smith Building, Oxford Road, Manchester M13 9PT, UK
    FEBS Lett 580:1320-6. 2006
    ..The absence of apoptotic death correlates with a specific defect in activation of Bax. We conclude that JNK-dependent regulation of Bax is essential to mediate the apoptotic release of cytochrome c regardless of Bid and Bim activation...
  6. pmc Targeted deletion of the mitogen-activated protein kinase kinase 4 gene in the nervous system causes severe brain developmental defects and premature death
    Xin Wang
    Faculty of Life Sciences, Wellcome Trust Center for Cell Matrix Research, University of Manchester, Michael Smith Building, Oxford Road, Manchester M13 9PT, United Kingdom
    Mol Cell Biol 27:7935-46. 2007
    ..Together, our data demonstrate for the first time that MKK4 is an essential activator of JNK required for the normal development of the brain...
  7. pmc Selective regulation of c-jun gene expression by mitogen-activated protein kinases via the 12-o-tetradecanoylphorbol-13-acetate- responsive element and myocyte enhancer factor 2 binding sites
    Midori Kayahara
    Faculty of Life Sciences, University of Manchester, The Michael Smith Building, Oxford Road, Manchester M13 9PT, United Kingdom
    Mol Cell Biol 25:3784-92. 2005
    ..Overall, these data provide important insights into the mechanisms that ultimately determine the function of c-Jun as a regulator of cell fate...
  8. ncbi request reprint Physiological roles of MKK4 and MKK7: insights from animal models
    Xin Wang
    Faculty of Life Sciences, University of Manchester, Michael Smith Building, Oxford Road, Manchester M13 9PT, UK
    Biochim Biophys Acta 1773:1349-57. 2007
    ..For example, whereas MKK4 can activate p38 MAPK, MKK7 functions as a specific activator of JNK. Here we summarize the studies that have shed light on the mechanism of activation of MKK4 and MKK7 and on their physiological functions...
  9. pmc JNK and PTEN cooperatively control the development of invasive adenocarcinoma of the prostate
    Anette Hübner
    University of Massachusetts Medical School, Worcester, MA 01605, USA
    Proc Natl Acad Sci U S A 109:12046-51. 2012
    ..These data demonstrate that the JNK and PTEN signaling pathways can cooperate to regulate the progression of prostate neoplasia to invasive adenocarcinoma...
  10. doi request reprint The loss of c-Jun N-terminal protein kinase activity prevents the amyloidogenic cleavage of amyloid precursor protein and the formation of amyloid plaques in vivo
    Sonia Mazzitelli
    Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, United Kingdom
    J Neurosci 31:16969-76. 2011
    ..Therefore, inhibition of increased JNK activity associated with aging or with a pathological condition constitutes a potential strategy for the treatment of AD...
  11. pmc Targeted deletion of mek5 causes early embryonic death and defects in the extracellular signal-regulated kinase 5/myocyte enhancer factor 2 cell survival pathway
    Xin Wang
    University of Manchester, The Michael Smith Building, Oxford Road, Manchester M13 9PT, United Kingdom
    Mol Cell Biol 25:336-45. 2005
    ..Overall, this is the first study to rigorously establish the role of MEK5 in vivo as an activator of ERK5 and as an essential regulator of cell survival that is required for normal embryonic development...
  12. doi request reprint Exploring the function of the JNK (c-Jun N-terminal kinase) signalling pathway in physiological and pathological processes to design novel therapeutic strategies
    Clare Davies
    Faculty of Life Sciences, University of Manchester, Michael Smith Building, Oxford Road, Manchester M13 9PT, UK
    Biochem Soc Trans 40:85-9. 2012
    ..Further insights into the specific functions of the JNK activators in cancer cells and in neurons will be of critical importance to validate MKK4 and MKK7 as promising drug targets...
  13. ncbi request reprint Activation of integrin alpha5beta1 delays apoptosis of Ntera2 neuronal cells
    Rosemary M Gibson
    Faculty of Life Sciences, University of Manchester, 1 124 Stopford Building, Oxford Road, Manchester, M13 9PT, UK
    Mol Cell Neurosci 28:588-98. 2005
    ..The antibody 12G10 specifically delayed loss of phosphorylation of AKT on serine 473, and GSK-3beta on serine 9, induced by serum withdrawal, suggesting that these kinases are critical sensors of integrin activation on neuronal cells...
  14. doi request reprint The extracellular-regulated protein kinase 5 (ERK5) promotes cell proliferation through the down-regulation of inhibitors of cyclin dependent protein kinases (CDKs)
    Diana Perez-Madrigal
    University of Manchester, Faculty of Life Sciences, Manchester, UK
    Cell Signal 24:2360-8. 2012
    ..Together with evidence that cancer patients with poor prognosis display a high level of expression of components of the ERK5 signaling pathway, these findings support the hypothesis that ERK5 can be a potential target for cancer therapy...
  15. pmc The mitogen-activated protein kinase kinase 4 has a pro-oncogenic role in skin cancer
    Katherine G Finegan
    Faculty of Life Sciences, University of Manchester, Michael Smith Building, Oxford Road, Manchester, United Kingdom
    Cancer Res 70:5797-806. 2010
    ..Together, our results provide the first genetic demonstration that MKK4 is essential to mediate the oncogenic effect of Ras in vivo, thereby validating MKK4 as a potential drug target for cancer therapy...
  16. pmc The requirement of uncoordinated 51-like kinase 1 (ULK1) and ULK2 in the regulation of autophagy
    Eun Ju Lee
    Faculty of Life Sciences, University of Manchester, Manchester, UK
    Autophagy 7:689-95. 2011
    ..Together, these results provide strong genetic evidence that ULK1 is an essential component of the autophagic signaling pathway. The ability of ULK2 to compensate for the loss of ULK1 function is cell-type specific...
  17. pmc Integration of protein kinases mTOR and extracellular signal-regulated kinase 5 in regulating nucleocytoplasmic localization of NFATc4
    Teddy T C Yang
    Department of Molecular Pharmacology, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA
    Mol Cell Biol 28:3489-501. 2008
    ..These data also expand the repertoire of physiological substrates of mTOR and ERK5...
  18. doi request reprint ERK5 regulation in naïve T-cell activation and survival
    Olga Ananieva
    MRC Protein Phosphorylation Unit, College of Life Sciences, Sir James Black Centre, University of Dundee, Dundee, UK
    Eur J Immunol 38:2534-47. 2008
    ..These results suggest that while ERK5 does contribute to Klf2 regulation in T cells, it is not essential for the expression of CD62L or T-cell survival...