Research Topics
| David R TomlinsonSummaryAffiliation: University of Manchester Country: UK Publications
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Detail Information
Publications
Neurotrophin-3 prevents the proximal accumulation of neurofilament proteins in sensory neurons of streptozocin-induced diabetic ratsNicola M Sayers
School of Biological Sciences, University of Manchester, Manchester, UK
Diabetes 52:2372-80. 2003..It is proposed that the accumulation of NF-H and NF-M subunits in the proximal axon is an etiologic factor in the distal axon degeneration observed in diabetes...- Mitogen-activated protein kinase p38 mediates reduced nerve conduction velocity in experimental diabetic neuropathy: interactions with aldose reductaseSally A Price
Division of Neuroscience, School of Biological Sciences, University of Manchester, Stopford Building 1 124, Oxford Road, Manchester M13 9PT, UK
Diabetes 53:1851-6. 2004..Insulin and aldose reductase inhibitors can prevent excess polyol pathway flux, and hence these agents may prevent NCV deficits by preventing p38 MAP kinase activation... 
Diabetic neuropathies: components of etiologyDavid R Tomlinson
Faculty of Life Sciences, University of Manchester, Manchester, UK
J Peripher Nerv Syst 13:112-21. 2008..Recent work also links MAPK activation to the development of neuropathic pain...- Glucose neurotoxicityDavid R Tomlinson
Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester, M13 9PT, UK
Nat Rev Neurosci 9:36-45. 2008..This article reviews the pathophysiological manifestation of raised glucose in neurons and how this can explain the major components of diabetic neuropathy... - Thioredoxin interacting protein is increased in sensory neurons in experimental diabetesSally A Price
Faculty of Life Sciences, Stopford Building, University of Manchester, 3 613 4 Stopford Building, Oxford Road, Manchester M13 9PT, UK
Brain Res 1116:206-14. 2006..These results indicate another mechanism by which diabetes may cause oxidative damage in peripheral nerve, and may represent a novel target for therapeutic intervention... 
Advanced glycation end products in extracellular matrix proteins contribute to the failure of sensory nerve regeneration in diabetesBeatriz Duran-Jimenez
Faculty of Life Sciences, University of Manchester, Manchester, U K
Diabetes 58:2893-903. 2009..We also investigated the impact of advanced glycation end product (AGE) residue content of ECM on neurite outgrowth from sensory neurons...- Preconditioning injury-induced neurite outgrowth of adult rat sensory neurons on fibronectin is mediated by mobilisation of axonal alpha5 integrinNatalie J Gardiner
Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester, M13 9PT, UK
Mol Cell Neurosci 35:249-60. 2007..We show that alpha5 integrin localises to adhesion complexes in the growth cone and neurites of preconditioned neurons, but not control neurons... - Engineered zinc finger protein-mediated VEGF-a activation restores deficient VEGF-a in sensory neurons in experimental diabetesElizabeth J Pawson
Faculty of Life Sciences, University of Manchester, Manchester, UK
Diabetes 59:509-18. 2010.... - Alpha7 integrin mediates neurite outgrowth of distinct populations of adult sensory neuronsNatalie J Gardiner
School of Biological Sciences, University of Manchester, Manchester, M13 9PT, UK
Mol Cell Neurosci 28:229-40. 2005..These results define an essential interaction between alpha7 integrin and laminin for mediating neurite outgrowth of subpopulations of injured adult sensory neurons... - Activation of JNK in sensory neurons protects against sensory neuron cell death in diabetes and on exposure to glucose/oxidative stress in vitroSally A Price
Division of Neuroscience, 1 124 Stopford Building, University of Manchester, Manchester, M13 9PT, England, United Kingdom
Ann N Y Acad Sci 1010:95-9. 2003.... - Insulin prevents depolarization of the mitochondrial inner membrane in sensory neurons of type 1 diabetic rats in the presence of sustained hyperglycemiaTze-Jen Huang
School of Biological Sciences, University of Manchester, Manchester, UK
Diabetes 52:2129-36. 2003..05). The results demonstrate that loss of insulin-dependent neurotrophic support may contribute to mitochondrial membrane depolarization in sensory neurons in diabetic neuropathy... - Neuritin mediates nerve growth factor-induced axonal regeneration and is deficient in experimental diabetic neuropathyEugenia Karamoysoyli
Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester, M13 9PT, UK
Diabetes 57:181-9. 2008..The mechanisms behind this failure are not fully understood; however, a deficit in neurotrophic support and signaling has been implicated... - Gene transfer of an engineered transcription factor promoting expression of VEGF-A protects against experimental diabetic neuropathySally A Price
Faculty of Life Sciences, University of Manchester, Manchester, UK
Diabetes 55:1847-54. 2006..These data suggest that VEGF-A-activating ZFP-TFs may ultimately be of clinical utility in the treatment of this disease... - Peripheral axon crush elevates transport of p75NTR in the central projection of sensory neurones of ratsJean Dominique Delcroix
School of Biological Sciences, University of Manchester, Manchester, UK
Neurosci Lett 351:181-5. 2003..Sciatic nerve crush induced a 2-fold increase (P<0.05) in the bidirectional axonal transport of p75(NTR) in the dorsal root while trkA transport remained below detectable levels... - Inhibition of p38 MAP kinase corrects biochemical and neurological deficits in experimental diabetic neuropathySithiporn Agthong
Division of Neuroscience, School of Biological Sciences, University of Manchester, Oxford Road, Manchester M13 9PT, UK
Ann N Y Acad Sci 973:359-62. 2002..This implicates activation of MAP kinase p38 as an early step in the signal pathway to dysfunction in experimental diabetic neuropathy... - Diminished transcription factor survival signals in dorsal root ganglia in rats with streptozotocin-induced diabetesTertia D Purves
Neuroscience Division, Manchester University, Manchester, M13 9PT, England, UK
Ann N Y Acad Sci 973:472-6. 2002..Thus, these changes my underlie consequences of impaired neurotrophic regulation of phenotype reported in other studies in diabetic rats... - Therapeutic efficacy of sonic hedgehog protein in experimental diabetic neuropathyNigel A Calcutt
Department of Pathology, University of California at San Diego, La Jolla, California 92093 0612, USA
J Clin Invest 111:507-14. 2003.... - Are mitogen-activated protein kinases glucose transducers for diabetic neuropathies?Tertia D Purves
Neuroscience Division, University of Manchester, School of Biological Sciences, Manchester M13 9PT, United Kingdom
Int Rev Neurobiol 50:83-114. 2002