Affiliation: University College London
Location: London, UK
Collopy L, Ware T, Goncalves T, Ã Kongsstovu S, Yang Q, Amelina H, et al
. LARP7 family proteins have conserved function in telomerase assembly. Nat Commun. 2018;9:557 pubmed publisher
..Collectively, we demonstrate that Lar7 is a crucial player in fission yeast telomerase biogenesis, similarly to p65 in Tetrahymena, and highlight the LARP7 family as a conserved factor in telomere maintenance. ..
Tomita K, Bez C, Fennell A, Cooper J. A single internal telomere tract ensures meiotic spindle formation. EMBO Rep. 2013;14:252-60 pubmed publisher
..Moreover, the telomeric overhang-binding protein Pot1 is dispensable for rescue of spindle formation. Hence, an inherent feature of the double-strand telomeric region endows telomeres with the capacity to promote spindle formation. ..
Amelina H, Subramaniam S, Moiseeva V, Armstrong C, Pearson S, Tomita K. Telomere protein Rap1 is a charge resistant scaffolding protein in chromosomal bouquet formation. BMC Biol. 2015;13:37 pubmed publisher
..Thus, Rap1 is able to retain bouquet formation under heavily phosphorylated status. ..
Armstrong C, Pearson S, Amelina H, Moiseeva V, Tomita K. Telomerase activation after recruitment in fission yeast. Curr Biol. 2014;24:2006-11 pubmed publisher
..Our findings reveal a layer of telomerase regulation that controls activity after recruitment. ..
Amelina H, Moiseeva V, Collopy L, Pearson S, Armstrong C, Tomita K. Sequential and counter-selectable cassettes for fission yeast. BMC Biotechnol. 2016;16:76 pubmed
..The plasmid constructs and techniques described here are invaluable tools for sequential gene targeting and will simplify construction of fission yeast strains required for study. ..
Armstrong C, Tomita K. Fundamental mechanisms of telomerase action in yeasts and mammals: understanding telomeres and telomerase in cancer cells. Open Biol. 2017;7: pubmed publisher
..Finally, we discuss the differences in telomere homeostasis between normal cells and cancer cells, which may provide a foundation for telomere/telomerase targeted cancer treatments. ..