M Tomaszewski

Summary

Affiliation: University of Leicester
Country: UK

Publications

  1. pmc Inheritance of coronary artery disease in men: an analysis of the role of the Y chromosome
    Fadi J Charchar
    School of Health Sciences, University of Ballarat, Ballarat, Vic, Australia
    Lancet 379:915-22. 2012
  2. pmc Pathway analysis shows association between FGFBP1 and hypertension
    Maciej Tomaszewski
    Department of Cardiovascular Sciences, University of Leicester, Leicester NIHR Biomedical Research Unit in Cardiovascular Disease, Glenfield Hospital, Leicester LE3 9QP, UK
    J Am Soc Nephrol 22:947-55. 2011
  3. pmc A common variant in low-density lipoprotein receptor-related protein 6 gene (LRP6) is associated with LDL-cholesterol
    Maciej Tomaszewski
    Department of Cardiovascular Sciences, University of Leicester, Clinical Sciences Wing, Glenfield Hospital, Leicester, LE3 9QP, UK
    Arterioscler Thromb Vasc Biol 29:1316-21. 2009
  4. pmc Inverse associations between androgens and renal function: the Young Men Cardiovascular Association (YMCA) study
    Maciej Tomaszewski
    Department of Cardiovascular Sciences, University of Leicester, Leicester, UK
    Am J Hypertens 22:100-5. 2009
  5. pmc Association between lipid profile and circulating concentrations of estrogens in young men
    Maciej Tomaszewski
    Department of Cardiovascular Sciences, University of Leicester, Leicester, UK
    Atherosclerosis 203:257-62. 2009
  6. ncbi Fibroblast growth factor 1 gene and hypertension: from the quantitative trait locus to positional analysis
    Maciej Tomaszewski
    British Heart Foundation Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UK
    Circulation 116:1915-24. 2007
  7. ncbi Association studies in current cardiovascular genetics - functional variants, tags or both?
    M Tomaszewski
    Department of Cardiovascular Sciences, University of Leicester, Leicester, UK
    J Hum Hypertens 21:425-6. 2007
  8. ncbi Glomerular hyperfiltration: a new marker of metabolic risk
    M Tomaszewski
    BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UK
    Kidney Int 71:816-21. 2007
  9. ncbi Association of the human Y chromosome with cholesterol levels in the general population
    Fadi J Charchar
    BHF Glasgow Cardiovascular Research Centre, Division of Cardiovascular and Medical Sciences, University of Glasgow, Western Infirmary, Glasgow G11 6NT, United Kingdom
    Arterioscler Thromb Vasc Biol 24:308-12. 2004
  10. ncbi Cardiovascular diseases and G-protein beta3 subunit gene (GNB3) in the era of genomewide scans
    M Tomaszewski
    BHF Glasgow Cardiovascular Research Centre, Division of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK
    J Hum Hypertens 17:379-80. 2003

Detail Information

Publications29

  1. pmc Inheritance of coronary artery disease in men: an analysis of the role of the Y chromosome
    Fadi J Charchar
    School of Health Sciences, University of Ballarat, Ballarat, Vic, Australia
    Lancet 379:915-22. 2012
    ..We explored the role of the Y chromosome in coronary artery disease in the context of this sexual inequity...
  2. pmc Pathway analysis shows association between FGFBP1 and hypertension
    Maciej Tomaszewski
    Department of Cardiovascular Sciences, University of Leicester, Leicester NIHR Biomedical Research Unit in Cardiovascular Disease, Glenfield Hospital, Leicester LE3 9QP, UK
    J Am Soc Nephrol 22:947-55. 2011
    ..Taken together, these data suggest that FGFBP1 associates with hypertension and that systematic analysis of signaling pathways can identify previously undescribed genetic associations...
  3. pmc A common variant in low-density lipoprotein receptor-related protein 6 gene (LRP6) is associated with LDL-cholesterol
    Maciej Tomaszewski
    Department of Cardiovascular Sciences, University of Leicester, Clinical Sciences Wing, Glenfield Hospital, Leicester, LE3 9QP, UK
    Arterioscler Thromb Vasc Biol 29:1316-21. 2009
    ..We hypothesized that common variants in LRP6 could predispose subjects to elevated LDL-cholesterol (LDL-C)...
  4. pmc Inverse associations between androgens and renal function: the Young Men Cardiovascular Association (YMCA) study
    Maciej Tomaszewski
    Department of Cardiovascular Sciences, University of Leicester, Leicester, UK
    Am J Hypertens 22:100-5. 2009
    ..Men exhibit higher risk of nondiabetic renal diseases than women. This male susceptibility to renal disease may be mediated by gender-specific factors such as sex hormones...
  5. pmc Association between lipid profile and circulating concentrations of estrogens in young men
    Maciej Tomaszewski
    Department of Cardiovascular Sciences, University of Leicester, Leicester, UK
    Atherosclerosis 203:257-62. 2009
    ..Unlike androgens, estrogens were not extensively investigated in relation to cardiovascular phenotypes in men...
  6. ncbi Fibroblast growth factor 1 gene and hypertension: from the quantitative trait locus to positional analysis
    Maciej Tomaszewski
    British Heart Foundation Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UK
    Circulation 116:1915-24. 2007
    ..The distal portion of the long arm of chromosome 5 is linked to hypertension and contains functional candidate blood pressure-regulating genes...
  7. ncbi Association studies in current cardiovascular genetics - functional variants, tags or both?
    M Tomaszewski
    Department of Cardiovascular Sciences, University of Leicester, Leicester, UK
    J Hum Hypertens 21:425-6. 2007
  8. ncbi Glomerular hyperfiltration: a new marker of metabolic risk
    M Tomaszewski
    BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UK
    Kidney Int 71:816-21. 2007
    ..Furthermore, the results indicate that high metabolic risk is associated with glomerular hyperfiltration before overt manifestations of cardiovascular disease...
  9. ncbi Association of the human Y chromosome with cholesterol levels in the general population
    Fadi J Charchar
    BHF Glasgow Cardiovascular Research Centre, Division of Cardiovascular and Medical Sciences, University of Glasgow, Western Infirmary, Glasgow G11 6NT, United Kingdom
    Arterioscler Thromb Vasc Biol 24:308-12. 2004
    ..Males are at higher risk of cardiovascular diseases than females. The aim of the study was to test whether the potential of the Y chromosome to affect cardiovascular risk could be attributed to its influence on lipids...
  10. ncbi Cardiovascular diseases and G-protein beta3 subunit gene (GNB3) in the era of genomewide scans
    M Tomaszewski
    BHF Glasgow Cardiovascular Research Centre, Division of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK
    J Hum Hypertens 17:379-80. 2003
  11. doi The novel genetic variant predisposing to coronary artery disease in the region of the PSRC1 and CELSR2 genes on chromosome 1 associates with serum cholesterol
    Nilesh J Samani
    Department of Cardiovascular Sciences, University of Leicester, Clinical Sciences Wing, Glenfield Hospital, Groby Road, Leicester, LE3 9QP, UK
    J Mol Med (Berl) 86:1233-41. 2008
    ..The findings support further investigation of the role of these genes in cholesterol metabolism and coronary risk...
  12. ncbi Essential hypertension and beta2-adrenergic receptor gene: linkage and association analysis
    Maciej Tomaszewski
    British Heart Foundation Blood Pressure Group, Department of Medicine and Therapeutics, University of Glasgow, Glasgow, United Kingdom
    Hypertension 40:286-91. 2002
    ..The detailed analysis of 3 single nucleotide polymorphisms does not support the role of the beta2-adrenergic receptor gene as a major causative gene for the detected linkage...
  13. pmc Genetic architecture of ambulatory blood pressure in the general population: insights from cardiovascular gene-centric array
    Maciej Tomaszewski
    Department of Cardiovascular Sciences, University of Leicester, Clinical Sciences Wing, Glenfield Hospital, Leicester, UK
    Hypertension 56:1069-76. 2010
    ....
  14. doi Common variants in genes underlying monogenic hypertension and hypotension and blood pressure in the general population
    Martin D Tobin
    Department of Health Sciences and Genetics, University of Leicester, UK
    Hypertension 51:1658-64. 2008
    ..Notably, variants in KCNJ1, which causes Bartter syndrome type 2, were strongly associated, potentially providing a novel target for intervention...
  15. doi Association between anthropometric obesity measures and coronary artery disease: a cross-sectional survey of 16,657 subjects from 444 Polish cities
    B M Kaess
    Department of Cardiovascular Sciences, University of Leicester, Leicester LE3 9QP, UK
    Heart 96:131-5. 2010
    ..Excessive body weight is known to cluster with cardiovascular (CV) risk factors, but it is not clear which anthropometric obesity measure provides best independent predictive value of coronary artery disease (CAD)...
  16. ncbi Epistatic interaction between beta2-adrenergic receptor and neuropeptide Y genes influences LDL-cholesterol in hypertension
    Maciej Tomaszewski
    British Heart Foundation Glasgow Cardiovascular Research Centre, Division of Cardiovascular and Medical Sciences, University of Glasgow, Western Infirmary, Glasgow G11 6NT, United Kingdom
    Hypertension 44:689-94. 2004
    ....
  17. ncbi Corcoran Lecture. Cardiovascular genomics and oxidative stress
    Anna F Dominiczak
    BHF Glasgow Cardiovascular Research Centre, Division of Cardiovascular and Medical Sciences, Western Infirmary, University of Glasgow, Scotland, UK
    Hypertension 45:636-42. 2005
    ..Therefore, in parallel to genome-wide or proteome-wide studies, it will be constructive to pursue "pathwayomics" defined here as functional studies of a candidate pathway for disease pathogenesis...
  18. ncbi Y is there a risk to being male?
    Fadi J Charchar
    BHF Glasgow Cardiovascular Research Centre, Division of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow G11 6NT, Scotland, UK
    Trends Endocrinol Metab 14:163-8. 2003
    ....
  19. ncbi Serum C-reactive protein and lipids in ultra-Marathon runners
    Maciej Tomaszewski
    British Heart Foundation Glasgow Cardiovascular Research Centre, Division of Cardiovascular and Medical Sciences, and Department of Pathological Biochemistry, University of Glasgow, Glasgow, United Kingdom
    Am J Cardiol 94:125-6. 2004
    ..This exercise-induced reduction in low-density lipoprotein cholesterol was independent of the decrease in C-reactive protein levels...
  20. ncbi Strikingly low circulating CRP concentrations in ultramarathon runners independent of markers of adiposity: how low can you go?
    Maciej Tomaszewski
    British Heart Foundation Glasgow Cardiovascular Research Centre, Division of Cardiovascular and Medical Sciences, University of Glasgow, UK
    Arterioscler Thromb Vasc Biol 23:1640-4. 2003
    ....
  21. doi Gender and effects of a common genetic variant in the NOS1 regulator NOS1AP on cardiac repolarization in 3761 individuals from two independent populations
    Martin D Tobin
    Department of Health Sciences, University of Leicester, UK
    Int J Epidemiol 37:1132-41. 2008
    ..We investigated the association between rs10494366 in NOS1AP and QTc, and assessed gender-specific NOS1AP associations with QTc during rest and after exercise...
  22. ncbi [Fibroblast growth factor 1 gene and essential hypertension--from the chromosomal region linked to blood pressure to renal glomerulus]
    Ewa Zukowska-Szczechowska
    Katedra i Klinika Chorob Wewnetrznych, Diabetologii i Nefrologii SUM, Szpital Kliniczny nr 1, ul 3 Maja 13 15, 41 800 Zabrze
    Kardiol Pol 66:227-8. 2008
  23. ncbi The Y chromosome effect on blood pressure in two European populations
    Fadi J Charchar
    British Heart Foundation Blood Pressure Group, Department of Medicine, University of Glasgow, United Kingdom
    Hypertension 39:353-6. 2002
    ..The polymorphism in the aldosterone synthase gene may interact with the Y chromosome to increase the odds of an individual's developing higher BP...
  24. ncbi Cerebral hemodynamics and investigations of cerebral blood flow regulation
    Wojciech Rudzinski
    Department of Radiology, Division of Neuroradiology of the University of Pennsylvania, Philadelphia, PA 19104, USA
    Nucl Med Rev Cent East Eur 10:29-42. 2007
    ....
  25. ncbi [Monogenic hypertension]
    Beata Łacka
    Katedra i Klinika Chorob Wewnetrznych, Diabetologii i Nefrologii w Zabrzu Slaskiej Akademii Medycznej w Katowicach
    Przegl Lek 60:824-7. 2003
    ....
  26. ncbi [Role of advanced glycosylation end products in the pathogenesis of hypertension]
    Ewa Zukowska-Szczechowska
    Katedra i Klinika Chorob Wewnetrznych, Diabetologii i Nefrologii, Slaskiej Akademii Medycznej w Katowicach
    Przegl Lek 60:585-7. 2003
    ..The investigations aiming to explain the reasons of disturbed metabolism of AGEs in hypertension will implicate therapeutic interventions...
  27. ncbi Functional significance of single nucleotide polymorphisms within the 5'-flanking region of beta2-adrenergic receptor gene
    Maciej Tomaszewski
    J Hypertens 24:2473-4; author reply 2474-6. 2006
  28. ncbi Genetic information in the diagnosis and treatment of hypertension
    Maciej Tomaszewski
    Curr Hypertens Rep 8:309-16. 2006
    ....
  29. ncbi Selected climatic variables and blood pressure in Central European patients with chronic renal failure on haemodialysis treatment
    Grzegorz Wystrychowski
    Department of Internal Medecine, Diabetology and Nephrology, Medical University of Silesia, Zabrze, Poland
    Blood Press 14:86-92. 2005
    ..The aim of the study was to assess whether BP varies similarly among patients with chronic renal failure on haemodialysis treatment, who present an increased risk of cardiovascular death...