J A Todd

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. pmc FUT2 nonsecretor status links type 1 diabetes susceptibility and resistance to infection
    Deborah J Smyth
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Diabetes 60:3081-4. 2011
  2. pmc An allele of IKZF1 (Ikaros) conferring susceptibility to childhood acute lymphoblastic leukemia protects against type 1 diabetes
    Austin D E Swafford
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Diabetes 60:1041-4. 2011
  3. pmc Inherited variation in vitamin D genes is associated with predisposition to autoimmune disease type 1 diabetes
    Jason D Cooper
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Diabetes 60:1624-31. 2011
  4. pmc Functional IL6R 358Ala allele impairs classical IL-6 receptor signaling and influences risk of diverse inflammatory diseases
    Ricardo C Ferreira
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, NIHR Cambridge Biomedical Research Centre, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom
    PLoS Genet 9:e1003444. 2013
  5. pmc Genetic association analyses of atopic illness and proinflammatory cytokine genes with type 1 diabetes
    Nada M Saleh
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke s Hospital, Cambridge CB2 0XY, UK
    Diabetes Metab Res Rev 27:838-43. 2011
  6. pmc Plasma concentrations of soluble IL-2 receptor α (CD25) are increased in type 1 diabetes and associated with reduced C-peptide levels in young patients
    Kate Downes
    JDRF Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, NIHR Cambridge Biomedical Research Centre, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke s Hospital, Cambridge, CB2 0XY, UK
    Diabetologia 57:366-72. 2014
  7. doi Constitutive antiviral immunity at the expense of autoimmunity
    John A Todd
    JDRF Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, NIHR Biomedical Research Centre, Cambridge Biomedical Campus, University of Cambridge, Hills Road, Cambridge CB2 0XY, UK Electronic address
    Immunity 40:167-9. 2014
  8. pmc Antibodies against insulin measured by electrochemiluminescence predicts insulitis severity and disease onset in non-obese diabetic mice and can distinguish human type 1 diabetes status
    Bernice Lo
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Transl Med 9:203. 2011
  9. pmc Evidence of association with type 1 diabetes in the SLC11A1 gene region
    Jennie H M Yang
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke s Hospital, Hills Road, Cambridge CB2 0XY, UK
    BMC Med Genet 12:59. 2011
  10. pmc Contrasting genetic association of IL2RA with SLE and ANCA-associated vasculitis
    Edward J Carr
    Cambridge Institute for Medical Research, University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, Hills Road, Cambridge, CB2 0XY, UK
    BMC Med Genet 10:22. 2009

Detail Information

Publications114 found, 100 shown here

  1. pmc FUT2 nonsecretor status links type 1 diabetes susceptibility and resistance to infection
    Deborah J Smyth
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Diabetes 60:3081-4. 2011
    ..This mutation has been reported to provide resistance to Norovirus and susceptibility to Crohn's disease, and hence we aimed to determine if it also affects risk of type 1 diabetes...
  2. pmc An allele of IKZF1 (Ikaros) conferring susceptibility to childhood acute lymphoblastic leukemia protects against type 1 diabetes
    Austin D E Swafford
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Diabetes 60:1041-4. 2011
    ..Because recent genome-wide association (GWA) studies have linked a region of the 3'-UTR of IKZF1 with C-ALL susceptibility, we tested whether IKZF1 is associated with the autoimmune disease type 1 diabetes...
  3. pmc Inherited variation in vitamin D genes is associated with predisposition to autoimmune disease type 1 diabetes
    Jason D Cooper
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Diabetes 60:1624-31. 2011
    ....
  4. pmc Functional IL6R 358Ala allele impairs classical IL-6 receptor signaling and influences risk of diverse inflammatory diseases
    Ricardo C Ferreira
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, NIHR Cambridge Biomedical Research Centre, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom
    PLoS Genet 9:e1003444. 2013
    ....
  5. pmc Genetic association analyses of atopic illness and proinflammatory cytokine genes with type 1 diabetes
    Nada M Saleh
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke s Hospital, Cambridge CB2 0XY, UK
    Diabetes Metab Res Rev 27:838-43. 2011
    ....
  6. pmc Plasma concentrations of soluble IL-2 receptor α (CD25) are increased in type 1 diabetes and associated with reduced C-peptide levels in young patients
    Kate Downes
    JDRF Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, NIHR Cambridge Biomedical Research Centre, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke s Hospital, Cambridge, CB2 0XY, UK
    Diabetologia 57:366-72. 2014
    ....
  7. doi Constitutive antiviral immunity at the expense of autoimmunity
    John A Todd
    JDRF Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, NIHR Biomedical Research Centre, Cambridge Biomedical Campus, University of Cambridge, Hills Road, Cambridge CB2 0XY, UK Electronic address
    Immunity 40:167-9. 2014
    ..The authors show that the autoimmune disease-associated variant of human MDA5 is permanently switched on...
  8. pmc Antibodies against insulin measured by electrochemiluminescence predicts insulitis severity and disease onset in non-obese diabetic mice and can distinguish human type 1 diabetes status
    Bernice Lo
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Transl Med 9:203. 2011
    ..Therefore, a rapid, non-radioactive, and reproducible assay is highly desirable...
  9. pmc Evidence of association with type 1 diabetes in the SLC11A1 gene region
    Jennie H M Yang
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke s Hospital, Hills Road, Cambridge CB2 0XY, UK
    BMC Med Genet 12:59. 2011
    ..Here, we have conducted association analysis of this candidate gene region, and then investigated potential correlations between the most T1D-associated variant and RNA expression of the SLC11A1 gene and its splice isoform...
  10. pmc Contrasting genetic association of IL2RA with SLE and ANCA-associated vasculitis
    Edward J Carr
    Cambridge Institute for Medical Research, University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, Hills Road, Cambridge, CB2 0XY, UK
    BMC Med Genet 10:22. 2009
    ....
  11. pmc The candidate genes TAF5L, TCF7, PDCD1, IL6 and ICAM1 cannot be excluded from having effects in type 1 diabetes
    Jason D Cooper
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    BMC Med Genet 8:71. 2007
    ..In addition, we tested seven genes, TAF5L, PDCD1, TCF7, IL12B, IL6, ICAM1 and TBX21, with published marginal or inconsistent evidence of an association with type 1 diabetes...
  12. pmc Analysis of polymorphisms in 16 genes in type 1 diabetes that have been associated with other immune-mediated diseases
    Deborah J Smyth
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, Wellcome Trust MRC Building, Addenbrooke s Hospital, Hills Rd, Cambridge, CB2 2XY, UK
    BMC Med Genet 7:20. 2006
    ..Therefore, we tested the hypothesis that alleles of susceptibility genes previously associated with other immune-mediated diseases might perturb immune homeostasis, and hence also associate with predisposition to T1D...
  13. pmc Polymorphism discovery and association analyses of the interferon genes in type 1 diabetes
    Gerard A J Morris
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Institute for Medical Research, University of Cambridge, Addenbrooke s Hospital, Cambridge, CB2 2XY, UK
    BMC Genet 7:12. 2006
    ....
  14. pmc Sequencing and association analysis of the type 1 diabetes-linked region on chromosome 10p12-q11
    Sergey Nejentsev
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK
    BMC Genet 8:24. 2007
    ..Here, we studied sequence polymorphisms in 23 Mb on chromosome 10p12-q11, including the putative IDDM10 region, to identify genes associated with T1D...
  15. pmc Common polymorphism in H19 associated with birthweight and cord blood IGF-II levels in humans
    Clive J Petry
    Department of Paediatrics, University of Cambridge, Addenbrooke s Hospital Level 8, Box 116, Cambridge CB2 2QQ, UK
    BMC Genet 6:22. 2005
    ....
  16. pmc Construction and analysis of tag single nucleotide polymorphism maps for six human-mouse orthologous candidate genes in type 1 diabetes
    Lisa M Maier
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust MRC Building, Hills Road, Cambridge, UK
    BMC Genet 6:9. 2005
    ..2), FRAP1 (orthologous to Frap1 in Idd9.2), 4-1BB/CD137/TNFRSF9 (orthologous to 4-1bb/Cd137/Tnrfrsf9 in Idd9.3), CD101/IGSF2 (orthologous to Cd101/Igsf2 in Idd10), B2M (orthologous to B2m in Idd13) and VAV3 (orthologous to Vav3 in Idd18)...
  17. pmc Investigating the utility of combining phi29 whole genome amplification and highly multiplexed single nucleotide polymorphism BeadArray genotyping
    Rebecca Pask
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes, Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust MRC Building, Cambridge, CB2 2XY, UK
    BMC Biotechnol 4:15. 2004
    ..As part of a large-scale BeadArray genotyping experiment we made a direct comparison of genotyping data generated from MDA product with that from genomic DNA (gDNA) templates...
  18. pmc Genome bioinformatic analysis of nonsynonymous SNPs
    David F Burke
    Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge, CB2 1GA, UK
    BMC Bioinformatics 8:301. 2007
    ....
  19. pmc Strategies for the prevention of autoimmune type 1 diabetes
    J A Todd
    University of Cambridge, UK
    Diabet Med 28:1141-3. 2011
    ..Combinations of interventions should be considered as they may allow targeting different components of disease, thus lowering side effects while increasing efficacy...
  20. pmc Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes
    John A Todd
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, University of Cambridge, Addenbrooke s Hospital, Cambridge CB2 0XY, UK
    Nat Genet 39:857-64. 2007
    ..Several regions, including 18q22 and 18p11, showed association with autoimmune thyroid disease. This study increases the number of T1D loci with compelling evidence from six to at least ten...
  21. ncbi Statistical false positive or true disease pathway?
    John A Todd
    University of Cambridge, Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, Addenbrooke s Hospital Cambridge, Cambridgeshire CB2 2XY, UK
    Nat Genet 38:731-3. 2006
    ..Given 20 years of a literature full of irreproducible results, what has changed?..
  22. ncbi Genetic protection from the inflammatory disease type 1 diabetes in humans and animal models
    J A Todd
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 2XY, United Kingdom
    Immunity 15:387-95. 2001
    ..Identification of these alleles, some which are likely to function in immune recognition, tolerance, and regulation, will facilitate the development of diagnostics as well as therapeutics that alter disease progression...
  23. doi Etiology of type 1 diabetes
    John A Todd
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, UK
    Immunity 32:457-67. 2010
    ..Certain inherited immune phenotypes will be early precursors of type 1 diabetes and could be useful in future clinical trials...
  24. pmc Shared and distinct genetic variants in type 1 diabetes and celiac disease
    Deborah J Smyth
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke s Hospital, Cambridge, United Kingdom
    N Engl J Med 359:2767-77. 2008
    ..Since both diseases are associated with the HLA class II genes on chromosome 6p21, we tested whether non-HLA loci are shared...
  25. pmc CD226 Gly307Ser association with multiple autoimmune diseases
    J P Hafler
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, Addenbrooke s Hospital, University of Cambridge, Cambridge, UK
    Genes Immun 10:5-10. 2009
    ..20 x 10(-4)) and rheumatoid arthritis (RA) (P=0.017). The Ser(307) allele of rs763361 in exon 7 of CD226 predisposes to T1D, MS, and possibly AITD and RA, and based on the tag SNP analysis, could be the causal variant...
  26. ncbi Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes
    Christopher E Lowe
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke s Hospital, UK
    Nat Genet 39:1074-82. 2007
    ..635). Furthermore, we have associated IL2RA T1D susceptibility genotypes with lower circulating levels of the biomarker, soluble IL-2RA (P = 6.28 x 10(-28)), suggesting that an inherited lower immune responsiveness predisposes to T1D...
  27. ncbi Testing the possible negative association of type 1 diabetes and atopic disease by analysis of the interleukin 4 receptor gene
    L M Maier
    JDRF WT Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK
    Genes Immun 4:469-75. 2003
    ..001 in the combined and P=0.02 in the Finnish data set). We, therefore, cannot rule out a genetic effect of IL4RA in T1D, but it is not a major one...
  28. pmc Confirmation of HLA class II independent type 1 diabetes associations in the major histocompatibility complex including HLA-B and HLA-A
    J M M Howson
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Diabetes Obes Metab 11:31-45. 2009
    ..Here we test for HLA class II-independent associations in the MHC using fine mapping data generated by the Type 1 Diabetes Genetics Consortium (T1DGC)...
  29. ncbi Identification of the sources of error in allele frequency estimations from pooled DNA indicates an optimal experimental design
    B J Barratt
    JDRF WT Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust MRC Building, Hills Road, Cambridge, CB2 2XY, UK
    Ann Hum Genet 66:393-405. 2002
    ..In this way further savings in efficiency may be possible by using pooled allele frequency estimates to infer haplotype frequencies and hence, allele frequencies at untyped markers...
  30. pmc A type 1 diabetes subgroup with a female bias is characterised by failure in tolerance to thyroid peroxidase at an early age and a strong association with the cytotoxic T-lymphocyte-associated antigen-4 gene
    J M M Howson
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust MRC Building, Addenbrooke s Hospital, Cambridge, CB2 0XY, UK
    Diabetologia 50:741-6. 2007
    ..Using thyroid peroxidase autoantibodies (TPOAbs) as an indicator of thyroid autoimmunity, we assessed whether the association of these loci is different in type 1 diabetes patients with TPOAbs than in those without...
  31. ncbi Analysis of 17 autoimmune disease-associated variants in type 1 diabetes identifies 6q23/TNFAIP3 as a susceptibility locus
    E Y M G Fung
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK
    Genes Immun 10:188-91. 2009
    ..70 x 10(-3) to 3.20 x 10(-5). These findings extend our knowledge of susceptibility locus sharing across different autoimmune diseases, and provide convincing evidence that the RA/SLE locus 6q23/TNFAIP3 is a newly identified T1D locus...
  32. pmc Statistical modeling of interlocus interactions in a complex disease: rejection of the multiplicative model of epistasis in type 1 diabetes
    H J Cordell
    Department of Medical Genetics, University of Cambridge, Wellcome Trust Centre for Molecular Mechanisms in Disease, Addenbrooke s Hospital, Hills Road, Cambridge, CB2 2XY, United Kingdom
    Genetics 158:357-67. 2001
    ..The degree to which statistical analyses can elucidate underlying biologic mechanisms may be limited and may require prior knowledge of the underlying etiology...
  33. pmc Analysis of 55 autoimmune disease and type II diabetes loci: further confirmation of chromosomes 4q27, 12q13.2 and 12q24.13 as type I diabetes loci, and support for a new locus, 12q13.3-q14.1
    J D Cooper
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke s Hospital, Hills Road, Cambridge, UK
    Genes Immun 10:S95-120. 2009
    ..0 x 10(-4); odds ratio (OR)=0.92, 95% CI=0.88-0.96). This region, which contains many genes, has also been associated with rheumatoid arthritis...
  34. ncbi PTPN22 Trp620 explains the association of chromosome 1p13 with type 1 diabetes and shows a statistical interaction with HLA class II genotypes
    Deborah J Smyth
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Diabetes 57:1730-7. 2008
    ....
  35. pmc Cell-specific protein phenotypes for the autoimmune locus IL2RA using a genotype-selectable human bioresource
    Calliope A Dendrou
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke s Hospital, Hills Road, Cambridge, UK
    Nat Genet 41:1011-5. 2009
    ....
  36. pmc Analysis of 19 genes for association with type I diabetes in the Type I Diabetes Genetics Consortium families
    J M M Howson
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke s Hospital, Hills Road, Cambridge, UK
    Genes Immun 10:S74-84. 2009
    ..0005), with RR=1.14 (1.06-1.23). In contrast, no convincing evidence of association was obtained for SUMO4, VDR, PAX4, OAS1, IRS1, IL4, IL4R, IL13, IL12B, CEACAM21 or CAPSL gene regions (http://www.T1DBase.org)...
  37. ncbi Analysis of the mouse CD30 gene: a candidate for the NOD mouse type 1 diabetes locus Idd9.2
    T Siegmund
    Wellcome Trust Centre for Molecular Mechanisms in Disease, University of Cambridge, Addenbrooke s Hospital, UK
    Diabetes 49:1612-6. 2000
    ..Given its role in protecting against autoimmunity, one or more of the coding variants within CD30 is a good candidate for the Idd9.2 etiological variant...
  38. ncbi Mapping by genetic interaction: high-resolution congenic mapping of the type 1 diabetes loci Idd10 and Idd18 in the NOD mouse
    P A Lyons
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge University, Cambridge, UK
    Diabetes 50:2633-7. 2001
    ..We have mapped the Idd10 and Idd18 loci to 1.3- and 2.0-cM intervals, respectively, by holding the Idd3 allele constant. In addition, we have excluded Csf1 and Nras as candidates for both loci...
  39. pmc Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A
    Sergey Nejentsev
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute of Medical Research, University of Cambridge, CB2 0XY, UK
    Nature 450:887-92. 2007
    ..Taken together with previous studies, we conclude that MHC-class-I-mediated events, principally involving HLA-B*39, contribute to the aetiology of type 1 diabetes...
  40. ncbi No evidence for association of OAS1 with type 1 diabetes in unaffected siblings or type 1 diabetic cases
    Deborah J Smyth
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, Wellcome Trust MRC Building, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2XY, U K
    Diabetes 55:1525-8. 2006
    ..99; P = 0.83). These results suggest that additional evidence of association of a low penetrance effect in common disease should be sought when the primary result comes from unaffected siblings in the absence of any effect in cases...
  41. pmc Development of an integrated genome informatics, data management and workflow infrastructure: a toolbox for the study of complex disease genetics
    Oliver S Burren
    Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust MRC Building, Addenbrooke s Hospital, Cambridge, CB2 2XY, UK
    Hum Genomics 1:98-109. 2004
    ..Our system is applicable to any genetic study of complex disease, of either large or small scale...
  42. pmc No association of multiple type 2 diabetes loci with type 1 diabetes
    S M Raj
    Cambridge Institute for Medical Research, University of Cambridge, UK
    Diabetologia 52:2109-16. 2009
    ..11 at a false-positive rate of 0.003...
  43. pmc HLA class II gene associations in African American type 1 diabetes reveal a protective HLA-DRB1*03 haplotype
    J M M Howson
    JDRF Wellcome Trust Diabetes and Inflammation Laboratory, NIHR Biomedical Research Centre, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK
    Diabet Med 30:710-6. 2013
    ..We aimed to study the human leukocyte antigen (HLA) region in African American Type 1 diabetes...
  44. ncbi Suggestive evidence for association of human chromosome 18q12-q21 and its orthologue on rat and mouse chromosome 18 with several autoimmune diseases
    T R Merriman
    Wellcome Trust Centre for Molecular Mechanisms in Disease, University of Cambridge, UK
    Diabetes 50:184-94. 2001
    ..Collectively, these data suggest that a locus (or loci) exists on human chromosome 18q12-q21 that influences multiple autoimmune diseases and that this association might be conserved between species...
  45. pmc Association analysis of the IGF1 gene with childhood growth, IGF-1 concentrations and type 1 diabetes
    A Vella
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK
    Diabetologia 51:811-5. 2008
    ..We therefore examined the association between common genetic variation in IGF1 and predisposition to type 1 diabetes, childhood growth and metabolism...
  46. pmc Follow-up of 1715 SNPs from the Wellcome Trust Case Control Consortium genome-wide association study in type I diabetes families
    J D Cooper
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke s Hospital, Hills Road, Cambridge, UK
    Genes Immun 10:S85-94. 2009
    ..Both TLR8 and TLR7 are functional candidate genes owing to their key roles as pathogen recognition receptors and, in the case of TLR7, overexpression has been associated directly with murine autoimmune disease...
  47. ncbi Interactions between Idd5.1/Ctla4 and other type 1 diabetes genes
    Kara Hunter
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom
    J Immunol 179:8341-9. 2007
    ..This masking of CTLA-4 alleles by different genetic backgrounds provides an explanation for our observation that the human CTLA-4 gene is only associated with T1D in the subgroup of human T1D patients with anti-thyroid autoimmunity...
  48. ncbi Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease
    Hironori Ueda
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust MRC Building, Cambridge, CB2 2XY, UK
    Nature 423:506-11. 2003
    ..Genetic mapping of variants conferring a small disease risk can identify pathways in complex disorders, as exemplified by our discovery of inherited, quantitative alterations of CTLA4 contributing to autoimmune tissue destruction...
  49. pmc Common variants near MC4R are associated with fat mass, weight and risk of obesity
    Ruth J F Loos
    MRC Epidemiology Unit, Addenbrooke s Hospital, Cambridge CB2 0QQ, UK
    Nat Genet 40:768-75. 2008
    ....
  50. ncbi Population structure, differential bias and genomic control in a large-scale, case-control association study
    David G Clayton
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, University of Cambridge, Cambridge Institute for Medical Research, Wellcome Trust MRC Building, Cambridge, CB2 2XY, UK
    Nat Genet 37:1243-6. 2005
    ..To avoid excluding SNPs and losing valuable information, we extended the genomic control method by applying a variable downweighting to each SNP...
  51. pmc Confirmation of novel type 1 diabetes risk loci in families
    J D Cooper
    Department of Medical Genetics, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Diabetologia 55:996-1000. 2012
    ....
  52. ncbi Interaction analysis of the CBLB and CTLA4 genes in type 1 diabetes
    Felicity Payne
    Juvenile Diabetes Research Foundation Wellcome Trust, Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust MRC Building, Addenbrooke s Hospital, Cambridge, UK
    J Leukoc Biol 81:581-3. 2007
    ....
  53. ncbi Sequencing-based genotyping and association analysis of the MICA and MICB genes in type 1 diabetes
    Sarah F Field
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Diabetes 57:1753-6. 2008
    ....
  54. pmc Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes
    Jeffrey C Barrett
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Nat Genet 41:703-7. 2009
    ..01; overall P < 5 × 10(-8)) and 4 additional regions provided nominal evidence of replication (P < 0.05). The many new candidate genes suggested by these results include IL10, IL19, IL20, GLIS3, CD69 and IL27...
  55. pmc Nonobese diabetic congenic strain analysis of autoimmune diabetes reveals genetic complexity of the Idd18 locus and identifies Vav3 as a candidate gene
    Heather I Fraser
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Cambridge
    J Immunol 184:5075-84. 2010
    ..This study also demonstrates that a congenic strain mapping approach can isolate closely linked susceptibility genes...
  56. ncbi Haplotype tag single nucleotide polymorphism analysis of the human orthologues of the rat type 1 diabetes genes Ian4 (Lyp/Iddm1) and Cblb
    Felicity Payne
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke s Hospital, Cambridge, U K
    Diabetes 53:505-9. 2004
    ..484 for IAN4L1 and 0.692 for CBLB, suggesting that neither gene influences susceptibility to common alleles of human type 1 diabetes in these populations...
  57. ncbi Limitations of stratifying sib-pair data in common disease linkage studies: an example using chromosome 10p14-10q11 in type 1 diabetes
    Gillian C L Johnson
    JDRF WT Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom
    Am J Med Genet 113:158-66. 2002
    ..These data highlight the limitations of stratifying small datasets (n < 500) by additional criteria and the recurrent problems of multiple testing in genetic analysis...
  58. ncbi Association mapping of complex diseases in linked regions: estimation of genetic effects and feasibility of testing rare variants
    William Y S Wang
    Department of Medical Genetics, University of Cambridge, Cambridge, UK
    Genet Epidemiol 24:36-43. 2003
    ..Under alternative models, provided epistatic effects are minor, larger achievable sample sizes will provide sufficient power to map almost any disease gene that may have initially contributed to linkage...
  59. pmc The imprinted DLK1-MEG3 gene region on chromosome 14q32.2 alters susceptibility to type 1 diabetes
    Chris Wallace
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Nat Genet 42:68-71. 2010
    ..2. The highest association was at marker rs2304256 (odds ratio (OR) = 0.86; 95%CI = 0.82-0.90) in the TYK2 gene, which has previously been associated with systemic lupus erythematosus and multiple sclerosis...
  60. ncbi No evidence for a major effect of two common polymorphisms of the catalase gene in type 1 diabetes susceptibility
    Rebecca Pask
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, CB2 2XY UK
    Diabetes Metab Res Rev 22:356-60. 2006
    ..Replication of association in independent, large-sample studies is essential to further identify the genes involved in T1D. Two single nucleotide polymorphisms (SNPs) in the catalase gene have been reported to be associated with T1D...
  61. pmc Unbiased application of the transmission/disequilibrium test to multilocus haplotypes
    F Dudbridge
    Wellcome Trust Centre for Molecular Mechanisms in Disease, University of Cambridge, United Kingdom
    Am J Hum Genet 66:2009-12. 2000
    ..An illustration using data from the insulin-gene region in type 1 diabetes shows that the validity and power of the TDT may vary by an order of magnitude, depending on the method of analysis...
  62. ncbi Haplotype tagging for the identification of common disease genes
    G C Johnson
    JDRF/WT Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust/Medical Research Council Building, Hills Road, Cambridge, UK
    Nat Genet 29:233-7. 2001
    ..A directed re-sequencing effort of the approximately 10% of the genome in or near genes in the major ethnic groups would aid the systematic evaluation of the common variant model of common disease...
  63. ncbi The usefulness of different density SNP maps for disease association studies of common variants
    William Y S Wang
    JDRF WT Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, UK
    Hum Mol Genet 12:3145-9. 2003
    ....
  64. ncbi Identification of a structurally distinct CD101 molecule encoded in the 950-kb Idd10 region of NOD mice
    Carlos Penha-Goncalves
    Juvenile Diabetes Research Foundation Wellcome Trust JDRF WT Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke s Hospital, Cambridge CB2 2XY, U K
    Diabetes 52:1551-6. 2003
    ....
  65. pmc Localization of a type 1 diabetes locus in the IL2RA/CD25 region by use of tag single-nucleotide polymorphisms
    Adrian Vella
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, Wellcome Trust Medical Research Council Building, Addenbrooke s Hospital, Cambridge, United Kingdom
    Am J Hum Genet 76:773-9. 2005
    ..3x10(-3); combined P=1.3x10(-10)). These results illustrate the utility of tag SNPs in a chromosome-regional test of disease association and justify future fine mapping of the causal variant in the region...
  66. pmc Association of the vitamin D metabolism gene CYP27B1 with type 1 diabetes
    Rebecca Bailey
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK
    Diabetes 56:2616-21. 2007
    ..Our aim was to study the association between the CYP27B1 and CYP24A1 gene polymorphisms and type 1 diabetes...
  67. ncbi Replication of an association between the lymphoid tyrosine phosphatase locus (LYP/PTPN22) with type 1 diabetes, and evidence for its role as a general autoimmunity locus
    Deborah Smyth
    Juvenile Diabetes Research Foundation JDRF Wellcome Trust WT Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research CIMR, University of Cambridge, Cambridge, UK
    Diabetes 53:3020-3. 2004
    ..24 x 10(-4); OR 1.43 [95% CI 1.17-1.76]). Taken together, these results indicate a more general association of the PTPN22 locus with autoimmune disease...
  68. ncbi Analysis of polymorphisms of the interleukin-18 gene in type 1 diabetes and Hardy-Weinberg equilibrium testing
    Jeffrey S Szeszko
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, UK
    Diabetes 55:559-62. 2006
    ....
  69. pmc Genetic analysis of completely sequenced disease-associated MHC haplotypes identifies shuffling of segments in recent human history
    James A Traherne
    Department of Pathology, Immunology Division, University of Cambridge, Cambridge, United Kingdom
    PLoS Genet 2:e9. 2006
    ....
  70. ncbi Resequencing and association analysis of the SP110 gene in adult pulmonary tuberculosis
    Jeffrey S Szeszko
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, Department of Medical Genetics, University of Cambridge, WT MRC building, Addenbrooke s Hospital, Cambridge, CB2 2XY, UK
    Hum Genet 121:155-60. 2007
    ..Our results indicate that common polymorphisms of the SP110 gene have no major effect on susceptibility to tuberculosis in this population...
  71. ncbi The sequence and gene characterization of a 400-kb candidate region for IDDM4 on chromosome 11q13
    R C Twells
    Wellcome Trust Centre for Molecular Mechanisms in Disease, University of Cambridge, Cambridge, United Kingdom
    Genomics 72:231-42. 2001
    ..The full-length C11orf23 cDNA is the first mammalian orthologue of the yeast SAP family to be identified. Identification of these four genes in a 400-kb region of the IDDM4 region underpins our strategy to identify the IDDM4 locus...
  72. pmc Genetic association of zinc transporter 8 (ZnT8) autoantibodies in type 1 diabetes cases
    J M M Howson
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, Department of Medical Genetics, University of Cambridge, Addenbrooke s Hospital, Hills Road, Cambridge CB2 0XY, UK
    Diabetologia 55:1978-84. 2012
    ..Apart from the SLC30A8 gene itself, little is known about the genetic basis of ZnT8A. We hypothesise that other loci in addition to SLC30A8 are associated with ZnT8A...
  73. ncbi Maternal-fetal interactions and birth order influence insulin variable number of tandem repeats allele class associations with head size at birth and childhood weight gain
    Ken K Ong
    Department of Pediatrics, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Diabetes 53:1128-33. 2004
    ..Our results indicate that complex prenatal and postnatal gene-maternal/fetal interactions influence size at birth and childhood risk factors for adult disease...
  74. ncbi Combining mouse congenic strains and microarray gene expression analyses to study a complex trait: the NOD model of type 1 diabetes
    Iain A Eaves
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust Medical Research Council Building, Addenbrooke s Hospital, Cambridge, CB2 2XY, UK
    Genome Res 12:232-43. 2002
    ..These observations have important implications for the design of future microarray-based studies in T1D and, more generally, for studies that aim to combine genome-wide expression profiling and congenic mapping...
  75. ncbi Natural genetic variants influencing type 1 diabetes in humans and in the NOD mouse
    Linda S Wicker
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, Wellcome Trust MRC Building, Addenbrooke s Hospital, University of Cambridge, Cambridge CB2 2XY, UK
    Novartis Found Symp 267:57-65; discussion 65-75. 2005
    ..There is also growing evidence that the initiation or progression of many autoimmune diseases is likely to be influenced by some of the same genes...
  76. ncbi Genome-wide association studies: theoretical and practical concerns
    William Y S Wang
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 2XY, UK
    Nat Rev Genet 6:109-18. 2005
    ....
  77. ncbi Cost-effective analysis of candidate genes using htSNPs: a staged approach
    C E Lowe
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust MRC Building, Cambridge, UK
    Genes Immun 5:301-5. 2004
    ..A saving of approximately 75% of potential genotyping reactions could be made with minimal loss of power. There was little evidence from our analysis for association between the TRANCE and RANK genes and T1D in the populations tested...
  78. pmc Congenic mapping of the type 1 diabetes locus, Idd3, to a 780-kb region of mouse chromosome 3: identification of a candidate segment of ancestral DNA by haplotype mapping
    P A Lyons
    Department of Medical Genetics, Wellcome Trust Centre for the Study of Molecular Mechanisms in Disease, University of Cambridge, UK
    Genome Res 10:446-53. 2000
    ..Instead, all of the current data support our hypothesis that Idd3 corresponds to amino acid variation at the amino terminus of Il2...
  79. pmc Rare variants of IFIH1, a gene implicated in antiviral responses, protect against type 1 diabetes
    Sergey Nejentsev
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, CB2 0XY, UK
    Science 324:387-9. 2009
    ..This finding firmly establishes the role of IFIH1 in T1D and demonstrates that resequencing studies can pinpoint disease-causing genes in genomic regions initially identified by GWASs...
  80. ncbi Comparative high-resolution analysis of linkage disequilibrium and tag single nucleotide polymorphisms between populations in the vitamin D receptor gene
    Sergey Nejentsev
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, UK
    Hum Mol Genet 13:1633-9. 2004
    ..Direct comparison indicates that the tag SNPs selected in one European population effectively predict the non-tag SNPs in the other Europeans, but not in the Gambians, for this region...
  81. pmc Replication analysis identifies TYK2 as a multiple sclerosis susceptibility factor
    Maria Ban
    Department of Clinical Neuroscience, Addenbrooke s, Hospital, University of Cambridge, Cambridge, UK
    Eur J Hum Genet 17:1309-13. 2009
    ....
  82. pmc Statistical independence of the colocalized association signals for type 1 diabetes and RPS26 gene expression on chromosome 12q13
    Vincent Plagnol
    Juveniles Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK
    Biostatistics 10:327-34. 2009
    ..Here, we derive and apply a statistical test of this hypothesis. We conclude that RPS26 expression is unlikely to be the molecular trait responsible for T1D susceptibility at this locus, at least not in a direct, linear connection...
  83. pmc Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci
    Jason D Cooper
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Nat Genet 40:1399-401. 2008
    ..7 x 10(-12)), 10p15 (PRKCQ, P = 3.7 x 10(-9)), 15q24 (CTSH, P = 3.2 x 10(-15)) and 22q13 (C1QTNF6, P = 2.0 x 10(-8))...
  84. ncbi Analysis of the vitamin D receptor gene sequence variants in type 1 diabetes
    Sergey Nejentsev
    Juvenile Diabetes Research Foundation Wellcome Trust DiabetesInflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, WT MRC building, Addenbrooke s Hospital, Cambridge, CB2 2XY, UK
    Diabetes 53:2709-12. 2004
    ..K. and found no evidence of association. Overall, our results indicate that common sequence variation in the VDR gene has no major effect in type 1 diabetes in the populations tested...
  85. ncbi Type 1 diabetes genes and pathways shared by humans and NOD mice
    Linda S Wicker
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, University of Cambridge, Cambridge Institute for Medical Research, Cambridge CB2 2XY, UK
    J Autoimmun 25:29-33. 2005
    ..These observations underscore the value of the NOD mouse model for mechanistic studies on human T1D-associated molecular and cellular pathways...
  86. ncbi A multimarker regression-based test of linkage for affected sib-pairs at two linked loci
    Mathew J Barber
    Department of Medical Genetics, University of Cambridge, Cambridge, United Kingdom
    Genet Epidemiol 30:191-208. 2006
    ..03 to 0.002, using different methods) approximately 15 cM centromeric of the original localisation...
  87. ncbi A genome-wide association study of nonsynonymous SNPs identifies a type 1 diabetes locus in the interferon-induced helicase (IFIH1) region
    Deborah J Smyth
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, Wellcome Trust MRC Building, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2XY, UK
    Nat Genet 38:617-9. 2006
    ..In 4,253 cases, 5,842 controls and 2,134 parent-child trio genotypes, the risk ratio for the minor allele of the nsSNP rs1990760 A --> G (A946T) was 0.86 (95% confidence interval = 0.82-0.90) at P = 1.42 x 10(-10)...
  88. ncbi Comparison of population- and family-based methods for genetic association analysis in the presence of interacting loci
    Joanna M M Howson
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, University of Cambridge, Cambridge Institute for Medical Research, Addenbrooke s Hospital, UK
    Genet Epidemiol 29:51-67. 2005
    ....
  89. ncbi Remapping the insulin gene/IDDM2 locus in type 1 diabetes
    Bryan J Barratt
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK
    Diabetes 53:1884-9. 2004
    ....
  90. ncbi Fine mapping, gene content, comparative sequencing, and expression analyses support Ctla4 and Nramp1 as candidates for Idd5.1 and Idd5.2 in the nonobese diabetic mouse
    Linda S Wicker
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 2XY, UK
    J Immunol 173:164-73. 2004
    ..Future experiments to test the identity of Idd5.1 and Idd5.2 as Ctla4 and Nramp1, respectively, can now be justified using approaches to specifically alter or mimic the candidate causative SNPs...
  91. ncbi Association of intercellular adhesion molecule-1 gene with type 1 diabetes
    Sergey Nejentsev
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke s Hospital, CB2 2XY, Cambridge, UK
    Lancet 362:1723-4. 2003
    ..91, p=0.03; 446 families, 0.60, p=0.006). Our data indicate an aetiological role for ICAM-1 in type 1 diabetes, which needs to be confirmed in future genetic and functional experiments...
  92. pmc Haplotype structure, LD blocks, and uneven recombination within the LRP5 gene
    Rebecca C J Twells
    JDRF WT Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 2XY, UK
    Genome Res 13:845-55. 2003
    ..The identification of hot spots in between these LD blocks provides additional evidence that LD blocks are separated by areas of higher recombination...
  93. ncbi Linkage and association mapping of the LRP5 locus on chromosome 11q13 in type 1 diabetes
    Rebecca C J Twells
    Department of Medical Genetics, JDRF WT Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust MRC Building, Addenbrooke s Hospital, Cambridge CB2 2XY, UK
    Hum Genet 113:99-105. 2003
    ..The continued search for the variants of the putative IDDM4 locus will greatly benefit from the future development of a haplotype map of the genome...
  94. ncbi A comprehensive, statistically powered analysis of GAD2 in type 1 diabetes
    Gillian C L Johnson
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, U K
    Diabetes 51:2866-70. 2002
    ..Our results suggest that GAD2 does not play a major role in type 1 diabetes in these two European populations...
  95. ncbi Parameters for reliable results in genetic association studies in common disease
    Ingrid Dahlman
    JDRF WT Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust MRC Building, Hills Road, Cambridge CB2 2XY, UK
    Nat Genet 30:149-50. 2002
    ..These results emphasize the need for large datasets, small P values and independent replication if results are to be reliable...
  96. pmc Commonality in the genetic control of Type 1 diabetes in humans and NOD mice: variants of genes in the IL-2 pathway are associated with autoimmune diabetes in both species
    Dan B Rainbow
    Juvenile Diabetes Research Foundation Wellcome Trust JDRF WT Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke s Hospital, UK
    Biochem Soc Trans 36:312-5. 2008
    ....
  97. pmc T1DBase, a community web-based resource for type 1 diabetes research
    Luc J Smink
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Wellcome Trust MRC Building, Cambridge CB2 2XY, UK
    Nucleic Acids Res 33:D544-9. 2005
    ..All data are open access and all software is open source...
  98. pmc A method to address differential bias in genotyping in large-scale association studies
    Vincent Plagnol
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom
    PLoS Genet 3:e74. 2007
    ..Therefore, we propose the use of "fuzzy" calls to deal with uncertain genotypes that would otherwise be labeled as missing...
  99. pmc Multi-parametric flow cytometric and genetic investigation of the peripheral B cell compartment in human type 1 diabetes
    W S Thompson
    JDRF Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, NIHR Cambridge Biomedical Research Centre, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK
    Clin Exp Immunol 177:571-85. 2014
    ..The IL2-IL21 association we have identified, if confirmed, suggests a novel role for B cells in T1D pathogenesis through the production of IL-10, and reinforces the importance of IL-10 production by autoreactive CD4(+) T cells. ..
  100. ncbi The MHC haplotype project: a resource for HLA-linked association studies
    R J N Allcock
    University of Cambridge, UK
    Tissue Antigens 59:520-1. 2002