A J Todd

Summary

Affiliation: University of Glasgow
Country: UK

Publications

  1. pmc Two populations of neurokinin 1 receptor-expressing projection neurons in lamina I of the rat spinal cord that differ in AMPA receptor subunit composition and density of excitatory synaptic input
    E Polgar
    Neuroscience and Molecular Pharmacology, Faculty of Biomedical and Life Sciences, West Medical Building, University Avenue, University of Glasgow, Glasgow G12 8QQ, UK
    Neuroscience 167:1192-204. 2010
  2. pmc A population of large neurons in laminae III and IV of the rat spinal cord that have long dorsal dendrites and lack the neurokinin 1 receptor
    Erika Polgár
    Spinal Cord Group, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK
    Eur J Neurosci 26:1587-98. 2007
  3. pmc Soma size distinguishes projection neurons from neurokinin 1 receptor-expressing interneurons in lamina I of the rat lumbar spinal dorsal horn
    K S Al Ghamdi
    Neuroscience and Molecular Pharmacology, Faculty of Biomedical and Life Sciences, West Medical Building, University Avenue, University of Glasgow, Glasgow G12 8QQ, UK
    Neuroscience 164:1794-804. 2009
  4. pmc Collateral projections of neurons in laminae I, III, and IV of rat spinal cord to thalamus, periaqueductal gray matter, and lateral parabrachial area
    Khulood M Al-Khater
    Neuroscience and Molecular Pharmacology, Faculty of Biomedical and Life Sciences, University of Glasgow, Glasgow, UK
    J Comp Neurol 515:629-46. 2009
  5. pmc Quantitative study of NPY-expressing GABAergic neurons and axons in rat spinal dorsal horn
    Erika Polgár
    Institute of Neuroscience and Psychology, University of Glasgow, Glasgow G128QQ, UK
    J Comp Neurol 519:1007-23. 2011
  6. pmc Populations of inhibitory and excitatory interneurons in lamina II of the adult rat spinal dorsal horn revealed by a combined electrophysiological and anatomical approach
    Toshiharu Yasaka
    Neuroscience and Molecular Pharmacology, Faculty of Biomedical and Life Sciences, University of Glasgow, Glasgow, UK
    Pain 151:475-88. 2010
  7. pmc Expression of AMPA receptor subunits at synapses in laminae I-III of the rodent spinal dorsal horn
    Erika Polgár
    Spinal Cord Group, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK
    Mol Pain 4:5. 2008
  8. pmc Phosphorylation of ERK in neurokinin 1 receptor-expressing neurons in laminae III and IV of the rat spinal dorsal horn following noxious stimulation
    Erika Polgár
    Spinal Cord Group, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK
    Mol Pain 3:4. 2007
  9. pmc A quantitative study of brainstem projections from lamina I neurons in the cervical and lumbar enlargement of the rat
    Erika Polgár
    Neuroscience and Molecular Pharmacology, Faculty of Biomedical and Life Sciences, West Medical Building, University of Glasgow, Glasgow G12 8QQ, UK
    Brain Res 1308:58-67. 2010
  10. pmc A quantitative study of spinothalamic neurons in laminae I, III, and IV in lumbar and cervical segments of the rat spinal cord
    Khulood M Al-Khater
    Spinal Cord Group, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, United Kingdom
    J Comp Neurol 511:1-18. 2008

Collaborators

Detail Information

Publications42

  1. pmc Two populations of neurokinin 1 receptor-expressing projection neurons in lamina I of the rat spinal cord that differ in AMPA receptor subunit composition and density of excitatory synaptic input
    E Polgar
    Neuroscience and Molecular Pharmacology, Faculty of Biomedical and Life Sciences, West Medical Building, University Avenue, University of Glasgow, Glasgow G12 8QQ, UK
    Neuroscience 167:1192-204. 2010
    ....
  2. pmc A population of large neurons in laminae III and IV of the rat spinal cord that have long dorsal dendrites and lack the neurokinin 1 receptor
    Erika Polgár
    Spinal Cord Group, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK
    Eur J Neurosci 26:1587-98. 2007
    ..The present findings demonstrate the need for caution when attempting to classify neurons solely on the basis of somatodendritic morphology...
  3. pmc Soma size distinguishes projection neurons from neurokinin 1 receptor-expressing interneurons in lamina I of the rat lumbar spinal dorsal horn
    K S Al Ghamdi
    Neuroscience and Molecular Pharmacology, Faculty of Biomedical and Life Sciences, West Medical Building, University Avenue, University of Glasgow, Glasgow G12 8QQ, UK
    Neuroscience 164:1794-804. 2009
    ..Since almost all of the NK1r-immunoreactive cells with soma size >200 microm(2) were retrogradely labelled, cells of this type can be identified as projection cells in anatomical studies...
  4. pmc Collateral projections of neurons in laminae I, III, and IV of rat spinal cord to thalamus, periaqueductal gray matter, and lateral parabrachial area
    Khulood M Al-Khater
    Neuroscience and Molecular Pharmacology, Faculty of Biomedical and Life Sciences, University of Glasgow, Glasgow, UK
    J Comp Neurol 515:629-46. 2009
    ..These results confirm that neurons in these laminae have extensive collateral projections and suggest that different neuronal subpopulations in lamina I have characteristic patterns of supraspinal projection...
  5. pmc Quantitative study of NPY-expressing GABAergic neurons and axons in rat spinal dorsal horn
    Erika Polgár
    Institute of Neuroscience and Psychology, University of Glasgow, Glasgow G128QQ, UK
    J Comp Neurol 519:1007-23. 2011
    ..These results show that NPY-containing neurons make up a considerable proportion of the inhibitory interneurons in laminae I-III, and that their axons preferentially target certain classes of dorsal horn neuron...
  6. pmc Populations of inhibitory and excitatory interneurons in lamina II of the adult rat spinal dorsal horn revealed by a combined electrophysiological and anatomical approach
    Toshiharu Yasaka
    Neuroscience and Molecular Pharmacology, Faculty of Biomedical and Life Sciences, University of Glasgow, Glasgow, UK
    Pain 151:475-88. 2010
    ..Combining this approach with identification of other neurochemical markers should allow further clarification of neuronal circuitry in the superficial dorsal horn...
  7. pmc Expression of AMPA receptor subunits at synapses in laminae I-III of the rodent spinal dorsal horn
    Erika Polgár
    Spinal Cord Group, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK
    Mol Pain 4:5. 2008
    ..In addition, we have compared staining of AMPArs with that for PSD-95, a major constituent of glutamatergic synapses. We also examined tissue from knock-out mice to confirm the validity of the immunostaining...
  8. pmc Phosphorylation of ERK in neurokinin 1 receptor-expressing neurons in laminae III and IV of the rat spinal dorsal horn following noxious stimulation
    Erika Polgár
    Spinal Cord Group, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK
    Mol Pain 3:4. 2007
    ..The stimuli were mechanical (repeated pinching), thermal (immersion in water at 52 degrees C) or chemical (injection of 2% formaldehyde)...
  9. pmc A quantitative study of brainstem projections from lamina I neurons in the cervical and lumbar enlargement of the rat
    Erika Polgár
    Neuroscience and Molecular Pharmacology, Faculty of Biomedical and Life Sciences, West Medical Building, University of Glasgow, Glasgow G12 8QQ, UK
    Brain Res 1308:58-67. 2010
    ..We also found that lamina I cells in L4 that project to the dorsal medulla are included in the population retrogradely labelled from LPb, thus confirming the estimate that there are around 400 lamina I projection cells in this segment...
  10. pmc A quantitative study of spinothalamic neurons in laminae I, III, and IV in lumbar and cervical segments of the rat spinal cord
    Khulood M Al-Khater
    Spinal Cord Group, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, United Kingdom
    J Comp Neurol 511:1-18. 2008
    ..Because PoT projects to second somatosensory and insular cortices, our results suggest that these are major targets for information conveyed by both these populations of spinothalamic neurons...
  11. pmc Neurokinin 1 receptor-expressing projection neurons in laminae III and IV of the rat spinal cord have synaptic AMPA receptors that contain GluR2, GluR3 and GluR4 subunits
    Andrew J Todd
    Neuroscience and Molecular Pharmacology, Faculty of Biomedical and Life Sciences, University of Glasgow, Glasgow, UK
    Eur J Neurosci 29:718-26. 2009
    ..These results show that synaptic AMPArs on the dendrites of the lamina III/IV NK1r projection neurons contain GluR2, GluR3 and GluR4, but not GluR1 subunits...
  12. ncbi Neurokinin 1 receptor expression by neurons in laminae I, III and IV of the rat spinal dorsal horn that project to the brainstem
    A J Todd
    Spinal Cord Group, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ UK
    Eur J Neurosci 12:689-700. 2000
    ..These results demonstrate that dorsal horn neurons which express the neurokinin 1 receptor contribute to several ascending pathways that are thought to be important in pain mechanisms...
  13. ncbi Projection neurons in lamina I of rat spinal cord with the neurokinin 1 receptor are selectively innervated by substance p-containing afferents and respond to noxious stimulation
    Andrew J Todd
    Spinal Cord Group, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, United Kingdom
    J Neurosci 22:4103-13. 2002
    ..We conclude that presence or absence of the NK1 receptor is a better indicator of function than morphology for lamina I projection neurons in the rat...
  14. ncbi Anatomy of primary afferents and projection neurones in the rat spinal dorsal horn with particular emphasis on substance P and the neurokinin 1 receptor
    A J Todd
    Spinal Cord Group, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK
    Exp Physiol 87:245-9. 2002
    ..These observations indicate that there are specific patterns of synaptic connectivity within the spinal dorsal horn...
  15. ncbi Fos induction in lamina I projection neurons in response to noxious thermal stimuli
    A J Todd
    Spinal Cord Group, Institute of Biomedical and Life Sciences, West Medical Building, University of Glasgow, Glasgow G12 8QQ, UK
    Neuroscience 131:209-17. 2005
    ..There therefore appears to be a correlation between morphology and function for lamina I projection neurons in the rat...
  16. ncbi The expression of vesicular glutamate transporters VGLUT1 and VGLUT2 in neurochemically defined axonal populations in the rat spinal cord with emphasis on the dorsal horn
    A J Todd
    Spinal Cord Group, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK
    Eur J Neurosci 17:13-27. 2003
    ..As all primary afferents are thought to be glutamatergic, this raises the possibility that unmyelinated afferents, most of which are nociceptors, express a different vesicular glutamate transporter...
  17. ncbi A population of large lamina I projection neurons with selective inhibitory input in rat spinal cord
    Z Puskar
    Spinal Cord Group, IBLS, University of Glasgow, G12 8QQ, Glasgow, UK
    Neuroscience 102:167-76. 2001
    ..These cells are under powerful inhibitory control, and the study provides further evidence that inhibitory circuits in the dorsal horn are organized in a specific manner...
  18. ncbi MOR-1-immunoreactive neurons in the dorsal horn of the rat spinal cord: evidence for nonsynaptic innervation by substance P-containing primary afferents and for selective activation by noxious thermal stimuli
    R C Spike
    Spinal Cord Group, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow, G12 8QQ, UK
    Eur J Neurosci 15:1306-16. 2002
    ....
  19. ncbi Selective innervation of lamina I projection neurones that possess the neurokinin 1 receptor by serotonin-containing axons in the rat spinal cord
    E Polgar
    Spinal Cord Group, IBLS, University of Glasgow, UK
    Neuroscience 109:799-809. 2002
    ....
  20. ncbi A quantitative and morphological study of projection neurons in lamina I of the rat lumbar spinal cord
    R C Spike
    Spinal Cord Group, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, United Kingdom
    Eur J Neurosci 18:2433-48. 2003
    ..These results suggest that many lamina I cells project to more than one site in the brain and that those projecting to PAG may represent a distinct subclass of lamina I projection neuron...
  21. pmc Large projection neurons in lamina I of the rat spinal cord that lack the neurokinin 1 receptor are densely innervated by VGLUT2-containing axons and possess GluR4-containing AMPA receptors
    Erika Polgár
    Faculty of Biomedical and Life Sciences, University of Glasgow, Glasgow, United Kingdom
    J Neurosci 28:13150-60. 2008
    ..Our results also provide the first evidence that postsynaptic GluR4-containing AMPA receptors are involved in spinal nociceptive transmission...
  22. pmc Tactile allodynia can occur in the spared nerve injury model in the rat without selective loss of GABA or GABA(A) receptors from synapses in laminae I-II of the ipsilateral spinal dorsal horn
    E Polgar
    Spinal Cord Group, Faculty of Biomedical and Life Sciences, West Medical Building, University of Glasgow, University Avenue, Glasgow G12 8QQ, UK
    Neuroscience 156:193-202. 2008
    ..An alternative explanation for disinhibition after nerve injury is that it results from reduced excitatory drive to GABAergic dorsal horn neurons following loss of primary afferent input to these cells...
  23. pmc P boutons in lamina IX of the rodent spinal cord express high levels of glutamic acid decarboxylase-65 and originate from cells in deep medial dorsal horn
    D I Hughes
    Spinal Cord Group, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, United Kingdom
    Proc Natl Acad Sci U S A 102:9038-43. 2005
    ..They also provide a means of identifying P boutons that will be important in studies of the organization of presynaptic control of Ia afferents...
  24. ncbi Selective loss of spinal GABAergic or glycinergic neurons is not necessary for development of thermal hyperalgesia in the chronic constriction injury model of neuropathic pain
    E Polgar
    Spinal Cord Group, Institute of Biomedical and Life Sciences, West Medical Building, University of Glasgow, Glasgow G12 8QQ, UK
    Pain 104:229-39. 2003
    ..Our results suggest that significant loss of GABAergic or glycinergic neurons is not necessary for the development of thermal hyperalgesia in the CCI model of neuropathic pain...
  25. ncbi Distribution and colocalisation of glutamate decarboxylase isoforms in the rat spinal cord
    M Mackie
    Spinal Cord Group, IBLS, West Medical Building, University of Glasgow, Glasgow G12 8QQ, UK
    Neuroscience 119:461-72. 2003
    ....
  26. ncbi Lack of evidence for significant neuronal loss in laminae I-III of the spinal dorsal horn of the rat in the chronic constriction injury model
    E Polgar
    Spinal Cord Group, Institute of Biomedical and Life Sciences, University of Glasgow, West Medical Building, Glasgow G12 8QQ, UK
    Pain 111:144-50. 2004
    ..These results do not, therefore, support the suggestion that there is significant neuronal death in the dorsal horn in this model...
  27. pmc Evidence against AMPA receptor-lacking glutamatergic synapses in the superficial dorsal horn of the rat spinal cord
    Toshiharu Yasaka
    Neuroscience and Molecular Pharmacology, Faculty of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, United Kingdom
    J Neurosci 29:13401-9. 2009
    ..This suggests that pure NMDAr-mediated EPSCs seen in previous studies do not correspond to AMPAr-lacking synapses but result from another mechanism, for example, loss of labile AMPArs from recently formed synapses...
  28. ncbi Widespread expression of the AMPA receptor GluR2 subunit at glutamatergic synapses in the rat spinal cord and phosphorylation of GluR1 in response to noxious stimulation revealed with an antigen-unmasking method
    Gergely G Nagy
    Spinal Cord Group, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, United Kingdom
    J Neurosci 24:5766-77. 2004
    ..This finding demonstrates plastic changes, presumably contributing to central sensitization, at the synaptic level...
  29. ncbi Lack of evidence for sprouting of Abeta afferents into the superficial laminas of the spinal cord dorsal horn after nerve section
    David I Hughes
    Spinal Cord Group, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, United Kingdom
    J Neurosci 23:9491-9. 2003
    ..Therefore these results do not support the hypothesis that Abeta afferents sprout into the superficial laminas after nerve section...
  30. pmc Upregulation of substance P in low-threshold myelinated afferents is not required for tactile allodynia in the chronic constriction injury and spinal nerve ligation models
    David I Hughes
    Spinal Cord Group, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, United Kingdom
    J Neurosci 27:2035-44. 2007
    ..They also suggest that any release of substance P from injured Abeta afferents is unlikely to activate NK1 receptors in the dorsal horn or contribute to neuropathic pain...
  31. ncbi Synaptic distribution of the NR1, NR2A and NR2B subunits of the N-methyl-d-aspartate receptor in the rat lumbar spinal cord revealed with an antigen-unmasking technique
    Gergely G Nagy
    Spinal Cord Group, West Medical Building, Institute of Biomedical and Life Sciences, University of Glasgow, University Avenue, Glasgow G12 8QQ, UK
    Eur J Neurosci 20:3301-12. 2004
    ..These results suggest that many, but not all, glutamatergic synapses in the spinal cord possess NMDA receptors and that subunit composition varies in different regions...
  32. ncbi Peripheral axotomy induces depletion of the vesicular glutamate transporter VGLUT1 in central terminals of myelinated afferent fibres in the rat spinal cord
    David I Hughes
    Spinal Cord Group, Institute of Biomedical and Life Sciences, University of Glasgow, West Medical Building, Glasgow G12 8QQ, UK
    Brain Res 1017:69-76. 2004
    ..This suggests that loss of VGLUT1 is more severe in proprioceptive than cutaneous afferents. Depletion of VGLUT1 may lead to a decrease in levels of transmitter glutamate in these afferents and thus to a reduction in synaptic efficacy...
  33. pmc A quantitative study of neuronal nitric oxide synthase expression in laminae I-III of the rat spinal dorsal horn
    T C P Sardella
    Institute of Neuroscience and Psychology, West Medical Building, University Avenue, University of Glasgow, Glasgow, G12 8QQ, UK
    Neuroscience 192:708-20. 2011
    ..They provide further evidence that axons of neurochemically defined populations of inhibitory interneuron are selective in their post-synaptic targets...
  34. pmc Neuronal circuitry for pain processing in the dorsal horn
    Andrew J Todd
    Institute of Neuroscience and Psychology, College of Medical, Veterinary and Life Sciences, West Medical Building, University of Glasgow, G12 8QQ, UK
    Nat Rev Neurosci 11:823-36. 2010
    ..Recent studies have begun to shed light on the neuronal organization and circuitry of this complex region...
  35. ncbi Loss of neurons from laminas I-III of the spinal dorsal horn is not required for development of tactile allodynia in the spared nerve injury model of neuropathic pain
    Erika Polgár
    Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, United Kingdom
    J Neurosci 25:6658-66. 2005
    ..These results suggest that a significant loss of neurons from the dorsal horn is not necessary for the development of tactile allodynia in the SNI model...
  36. ncbi Serotoninergic-mediated inhibition of substance P sensitive deep dorsal horn neurons: a combined electrophysiological and morphological study in vitro
    Matthew A Worsley
    School of Biomedical Sciences, University of Leeds, Leeds, LS2 9NQ, UK
    Exp Brain Res 160:360-7. 2005
    ..Inhibition by 5-HT of deep DH neurons directly responsive to SP may account at least in part for monoamine-induced modulation of nociceptive processing in the spinal cord...
  37. ncbi Do central terminals of intact myelinated primary afferents sprout into the superficial dorsal horn of rat spinal cord after injury to a neighboring peripheral nerve?
    Safa Aldeen S Shehab
    Department of Anatomy, Faculty of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates
    J Comp Neurol 474:427-37. 2004
    ..These results do not support the suggestion that the central terminals of intact myelinated afferents sprout into regions of lamina II occupied by adjacent nerves that have been axotomized peripherally...
  38. ncbi Anatomical evidence for an anticonvulsant relay in the rat ventromedial medulla
    Safa Shehab
    Department of Anatomy, Faculty of Medicine and Health Sciences, United Arab Emirates University, PO Box 17666, Al Ain, UAE
    Eur J Neurosci 22:1431-44. 2005
    ....
  39. ncbi Anti-disialoside antibodies kill perisynaptic Schwann cells and damage motor nerve terminals via membrane attack complex in a murine model of neuropathy
    Susan K Halstead
    Division of Clinical Neurosciences, Institute of Neurological Sciences, University of Glasgow Southern General Hospital, Glasgow G51 4TF, UK
    Brain 127:2109-23. 2004
    ..This is the first demonstration that complement mediated pSC injury occurs in a model of autoimmune neuropathy and provides a rationale for investigating the possibility of pSC injury in equivalent conditions in man...
  40. pmc Spinal cholinergic interneurons regulate the excitability of motoneurons during locomotion
    Gareth B Miles
    Department of Anatomy and Neurobiology, Dalhousie University, Halifax, NS, Canada B3H 1X5
    Proc Natl Acad Sci U S A 104:2448-53. 2007
    ..These results highlight a unique component of spinal motor networks that is critical in ensuring that sufficient output is generated by motoneurons to drive motor behavior...
  41. pmc Postnatal phenotype and localization of spinal cord V1 derived interneurons
    Francisco J Alvarez
    Department of Neuroscience, Cell Biology and Physiology, Wright State University, Dayton, Ohio 45435, USA
    J Comp Neurol 493:177-92. 2005
    ..In summary, V1 interneurons develop into ipsilaterally projecting, inhibitory interneurons that include Renshaw cells, Ia inhibitory interneurons, and other unidentified proprioceptive interneurons...
  42. ncbi Conditional rhythmicity of ventral spinal interneurons defined by expression of the Hb9 homeodomain protein
    Jennifer M Wilson
    Department of Anatomy and Neurobiology, Dalhousie University, Halifax, Nova Scotia, B3H 1X5, Canada
    J Neurosci 25:5710-9. 2005
    ....