D R Tocher
Affiliation: University of Stirling
Murray D, Hager H, Tocher D, Kainz M. Docosahexaenoic acid in Arctic charr (Salvelinus alpinus): the importance of dietary supply and physiological response during the entire growth period. Comp Biochem Physiol B Biochem Mol Biol. 2015;181:7-14 pubmed publisher
..Finally, this long-term feeding study in Arctic charr indicated a non-linear function in DHA retention in dorsal and ventral muscle tissues throughout the life cycle, which varied in its relationship to dietary DHA. ..
Morais S, Mourente G, MartÃnez A, Gras N, Tocher D. Docosahexaenoic acid biosynthesis via fatty acyl elongase and Î”4-desaturase and its modulation by dietary lipid level and fatty acid composition in a marine vertebrate. Biochim Biophys Acta. 2015;1851:588-97 pubmed publisher
..Results indicated functionality and biological relevance of the Î”4 LC-PUFA biosynthesis pathway in S. senegalensis. ..
Glencross B, De Santis C, Bicskei B, Taggart J, Bron J, Betancor M, et al
. A comparative analysis of the response of the hepatic transcriptome to dietary docosahexaenoic acid in Atlantic salmon (Salmo salar) post-smolts. BMC Genomics. 2015;16:684 pubmed publisher
..These findings suggest that in addition to clear roles in influencing lipid metabolic pathways, DHA might also have key functional roles in other pathways distinct from lipid metabolism. ..
KrÃ³l E, Douglas A, Tocher D, Crampton V, Speakman J, Secombes C, et al
. Differential responses of the gut transcriptome to plant protein diets in farmed Atlantic salmon. BMC Genomics. 2016;17:156 pubmed publisher
..Ultimately, understanding diet-gut interactions and intestinal homeostasis in farmed fish is important to maximise performance and to ensure that aquaculture continues to be a sustainable source of food for a growing world population. ..
Carmona AntoÃ±anzas G, Zheng X, Tocher D, Leaver M. Regulatory divergence of homeologous Atlantic salmon elovl5 genes following the salmonid-specific whole-genome duplication. Gene. 2016;591:34-42 pubmed publisher
Monroig O, de Llanos R, Varó I, Hontoria F, Tocher D, Puig S, et al
. Biosynthesis of Polyunsaturated Fatty Acids in Octopus vulgaris: Molecular Cloning and Functional Characterisation of a Stearoyl-CoA Desaturase and an Elongation of Very Long-Chain Fatty Acid 4 Protein. Mar Drugs. 2017;15: pubmed publisher
..Moreover, the octopus Elovl4 was confirmed to play a key role in the biosynthesis of very long-chain (>C24) PUFAs. ..
Vera L, Metochis C, Taylor J, Clarkson M, Skjærven K, Migaud H, et al
. Early nutritional programming affects liver transcriptome in diploid and triploid Atlantic salmon, Salmo salar. BMC Genomics. 2017;18:886 pubmed publisher
..In addition, differences between diploid and triploid salmon were found, supporting recent data that indicate nutritional requirements of triploid salmon may differ from those of their diploid counterparts. ..
Morais S, Silva T, Cordeiro O, Rodrigues P, Guy D, Bron J, et al
. Effects of genotype and dietary fish oil replacement with vegetable oil on the intestinal transcriptome and proteome of Atlantic salmon (Salmo salar). BMC Genomics. 2012;13:448 pubmed
Morais S, Pratoomyot J, Taggart J, Bron J, Guy D, Bell J, et al
. Genotype-specific responses in Atlantic salmon (Salmo salar) subject to dietary fish oil replacement by vegetable oil: a liver transcriptomic analysis. BMC Genomics. 2011;12:255 pubmed publisher
..Further studies are required but data suggest that it will be possible to identify families better adapted to alternative diet formulations that might be appropriate for future genetic selection programmes. ..