Martin D Tobin

Summary

Affiliation: University of Leicester
Country: UK

Publications

  1. ncbi request reprint Adjusting for treatment effects in studies of quantitative traits: antihypertensive therapy and systolic blood pressure
    Martin D Tobin
    Biostatistics and Genetic Epidemiology, Department of Health Sciences, University of Leicester, 22 28 Princess Road West, Leicester LE1 6TP, U K
    Stat Med 24:2911-35. 2005
  2. ncbi request reprint Selected climatic variables and blood pressure in Central European patients with chronic renal failure on haemodialysis treatment
    Grzegorz Wystrychowski
    Department of Internal Medecine, Diabetology and Nephrology, Medical University of Silesia, Zabrze, Poland
    Blood Press 14:86-92. 2005
  3. pmc Pedigree and genotyping quality analyses of over 10,000 DNA samples from the Generation Scotland: Scottish Family Health Study
    Shona M Kerr
    Centre for Molecular Medicine, University of Edinburgh, Institute of Genetics and Molecular Medicine, Western General Hospital, Crewe Road, Edinburgh, UK
    BMC Med Genet 14:38. 2013
  4. pmc Genome-wide linkage analysis of longitudinal phenotypes using sigma2A random effects (SSARs) fitted by Gibbs sampling
    Lyle J Palmer
    Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    BMC Genet 4:S12. 2003
  5. doi request reprint Gender and effects of a common genetic variant in the NOS1 regulator NOS1AP on cardiac repolarization in 3761 individuals from two independent populations
    Martin D Tobin
    Department of Health Sciences, University of Leicester, UK
    Int J Epidemiol 37:1132-41. 2008
  6. ncbi request reprint Commentary: development of Mendelian randomization: from hypothesis test to 'Mendelian deconfounding'
    Martin D Tobin
    University of Leicester, Department of Epidemiology and Public Health, 22 28 Princess Road West, Leicester LE1 6TP, UK
    Int J Epidemiol 33:26-9. 2004
  7. ncbi request reprint Genotypes and haplotypes predisposing to myocardial infarction: a multilocus case-control study
    Martin D Tobin
    Centre for Biostatistics and Genetic Epidemiology, Department of Health Sciences, University of Leicester, 22 28 Princess Road West, Leicester LE1 6TP, UK
    Eur Heart J 25:459-67. 2004
  8. ncbi request reprint South Asian ethnicity and risk of childhood accidents: an ecological study at enumeration district level in Leicester
    M D Tobin
    Department of Epidemiology and Public Health, University of Leicester, 22 28 Princess Road West, Leicester LE1 6TP
    J Public Health Med 24:313-8. 2002
  9. pmc Effect of five genetic variants associated with lung function on the risk of chronic obstructive lung disease, and their joint effects on lung function
    Maria Soler Artigas
    Department of Health Sciences, University of Leicester, Leicester, UK
    Am J Respir Crit Care Med 184:786-95. 2011
  10. doi request reprint Common variation in the WNK1 gene and blood pressure in childhood: the Avon Longitudinal Study of Parents and Children
    Martin D Tobin
    Departments of Health Sciences and Genetics, Genetic Epidemiology Group, University of Leicester, Leicester, United Kingdom
    Hypertension 52:974-9. 2008

Detail Information

Publications54

  1. ncbi request reprint Adjusting for treatment effects in studies of quantitative traits: antihypertensive therapy and systolic blood pressure
    Martin D Tobin
    Biostatistics and Genetic Epidemiology, Department of Health Sciences, University of Leicester, 22 28 Princess Road West, Leicester LE1 6TP, U K
    Stat Med 24:2911-35. 2005
    ..Given that the more effective methods are straightforward to implement, there is no argument for undertaking a flawed analysis that wastes power and results in excessive bias...
  2. ncbi request reprint Selected climatic variables and blood pressure in Central European patients with chronic renal failure on haemodialysis treatment
    Grzegorz Wystrychowski
    Department of Internal Medecine, Diabetology and Nephrology, Medical University of Silesia, Zabrze, Poland
    Blood Press 14:86-92. 2005
    ..The aim of the study was to assess whether BP varies similarly among patients with chronic renal failure on haemodialysis treatment, who present an increased risk of cardiovascular death...
  3. pmc Pedigree and genotyping quality analyses of over 10,000 DNA samples from the Generation Scotland: Scottish Family Health Study
    Shona M Kerr
    Centre for Molecular Medicine, University of Edinburgh, Institute of Genetics and Molecular Medicine, Western General Hospital, Crewe Road, Edinburgh, UK
    BMC Med Genet 14:38. 2013
    ..The few deviations in marker transmission in the 925 parent-child trios analysed were assessed as to whether they were likely to be miscalled genotypes, data or sample handling errors, or pedigree inaccuracies including non-paternity...
  4. pmc Genome-wide linkage analysis of longitudinal phenotypes using sigma2A random effects (SSARs) fitted by Gibbs sampling
    Lyle J Palmer
    Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    BMC Genet 4:S12. 2003
    ..We have now demonstrated in this paper the use of SSARs in the context of longitudinal family data...
  5. doi request reprint Gender and effects of a common genetic variant in the NOS1 regulator NOS1AP on cardiac repolarization in 3761 individuals from two independent populations
    Martin D Tobin
    Department of Health Sciences, University of Leicester, UK
    Int J Epidemiol 37:1132-41. 2008
    ..We investigated the association between rs10494366 in NOS1AP and QTc, and assessed gender-specific NOS1AP associations with QTc during rest and after exercise...
  6. ncbi request reprint Commentary: development of Mendelian randomization: from hypothesis test to 'Mendelian deconfounding'
    Martin D Tobin
    University of Leicester, Department of Epidemiology and Public Health, 22 28 Princess Road West, Leicester LE1 6TP, UK
    Int J Epidemiol 33:26-9. 2004
  7. ncbi request reprint Genotypes and haplotypes predisposing to myocardial infarction: a multilocus case-control study
    Martin D Tobin
    Centre for Biostatistics and Genetic Epidemiology, Department of Health Sciences, University of Leicester, 22 28 Princess Road West, Leicester LE1 6TP, UK
    Eur Heart J 25:459-67. 2004
    ..To identify polymorphisms and haplotypes in candidate genes that predispose to myocardial infarction (MI) using a multilocus approach...
  8. ncbi request reprint South Asian ethnicity and risk of childhood accidents: an ecological study at enumeration district level in Leicester
    M D Tobin
    Department of Epidemiology and Public Health, University of Leicester, 22 28 Princess Road West, Leicester LE1 6TP
    J Public Health Med 24:313-8. 2002
    ..Surveys of 'self-reported' accidents suggest that South Asian children in the United Kingdom may have lower rates of childhood accidents, but little is known about their susceptibility to severe accidents compared with white children...
  9. pmc Effect of five genetic variants associated with lung function on the risk of chronic obstructive lung disease, and their joint effects on lung function
    Maria Soler Artigas
    Department of Health Sciences, University of Leicester, Leicester, UK
    Am J Respir Crit Care Med 184:786-95. 2011
    ....
  10. doi request reprint Common variation in the WNK1 gene and blood pressure in childhood: the Avon Longitudinal Study of Parents and Children
    Martin D Tobin
    Departments of Health Sciences and Genetics, Genetic Epidemiology Group, University of Leicester, Leicester, United Kingdom
    Hypertension 52:974-9. 2008
    ..Our study suggests that previously reported effects of WNK1 variants on blood pressure are mediated via effects on the gradient of blood pressure change with age...
  11. pmc Genetic architecture of ambulatory blood pressure in the general population: insights from cardiovascular gene-centric array
    Maciej Tomaszewski
    Department of Cardiovascular Sciences, University of Leicester, Clinical Sciences Wing, Glenfield Hospital, Leicester, UK
    Hypertension 56:1069-76. 2010
    ....
  12. doi request reprint Common variants in genes underlying monogenic hypertension and hypotension and blood pressure in the general population
    Martin D Tobin
    Department of Health Sciences and Genetics, University of Leicester, UK
    Hypertension 51:1658-64. 2008
    ..Notably, variants in KCNJ1, which causes Bartter syndrome type 2, were strongly associated, potentially providing a novel target for intervention...
  13. pmc Pathway analysis shows association between FGFBP1 and hypertension
    Maciej Tomaszewski
    Department of Cardiovascular Sciences, University of Leicester, Leicester NIHR Biomedical Research Unit in Cardiovascular Disease, Glenfield Hospital, Leicester LE3 9QP, UK
    J Am Soc Nephrol 22:947-55. 2011
    ..Taken together, these data suggest that FGFBP1 associates with hypertension and that systematic analysis of signaling pathways can identify previously undescribed genetic associations...
  14. doi request reprint Meta-analysis of Mendelian randomization studies incorporating all three genotypes
    Tom M Palmer
    Department of Health Sciences, University of Leicester, Leicester, UK
    Stat Med 27:6570-82. 2008
    ..The methods are illustrated using a meta-analysis of the effect of a gene related to collagen production on bone mineral density and osteoporotic fracture...
  15. pmc Large-scale candidate gene analysis of HDL particle features
    Bernhard M Kaess
    Department of Cardiovascular Science, University of Leicester, Leicester, United Kingdom
    PLoS ONE 6:e14529. 2011
    ..We therefore assessed HDL particles by NMR spectroscopy and conducted a large-scale candidate gene association analysis...
  16. ncbi request reprint Meta-analysis of genetic studies using Mendelian randomization--a multivariate approach
    John R Thompson
    Department of Health Sciences, Centre for Biostatistics and Genetic Epidemiology, University of Leicester, 22 28 Princess Rd West, Leicester, LE1 6TP, U K
    Stat Med 24:2241-54. 2005
    ..We show how either maximum likelihood or a Bayesian approach with vague prior distributions can be used to fit the alternative model...
  17. pmc Identification of seven loci affecting mean telomere length and their association with disease
    Veryan Codd
    Department of Cardiovascular Sciences, University of Leicester, Leicester, UK
    Nat Genet 45:422-7, 427e1-2. 2013
    ..014). Our findings support a causal role of telomere-length variation in some age-related diseases...
  18. ncbi request reprint Association of WNK1 gene polymorphisms and haplotypes with ambulatory blood pressure in the general population
    Martin D Tobin
    Department of Health Sciences, University of Leicester, Leicester, England
    Circulation 112:3423-9. 2005
    ..Mutations in the WNK1 and WNK4 genes cause a rare monogenic hypertensive syndrome, pseudohypoaldosteronism type II. We investigated whether polymorphisms in these WNK genes influence BP in the general population...
  19. pmc Inverse associations between androgens and renal function: the Young Men Cardiovascular Association (YMCA) study
    Maciej Tomaszewski
    Department of Cardiovascular Sciences, University of Leicester, Leicester, UK
    Am J Hypertens 22:100-5. 2009
    ..Men exhibit higher risk of nondiabetic renal diseases than women. This male susceptibility to renal disease may be mediated by gender-specific factors such as sex hormones...
  20. pmc Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function
    Maria Soler Artigas
    Department of Health Sciences, University of Leicester, Leicester, UK
    Nat Genet 43:1082-90. 2011
    ..Identification of these 16 new loci may provide insight into the molecular mechanisms regulating pulmonary function and into molecular targets for future therapy to alleviate reduced lung function...
  21. doi request reprint The novel genetic variant predisposing to coronary artery disease in the region of the PSRC1 and CELSR2 genes on chromosome 1 associates with serum cholesterol
    Nilesh J Samani
    Department of Cardiovascular Sciences, University of Leicester, Clinical Sciences Wing, Glenfield Hospital, Groby Road, Leicester, LE3 9QP, UK
    J Mol Med (Berl) 86:1233-41. 2008
    ..The findings support further investigation of the role of these genes in cholesterol metabolism and coronary risk...
  22. pmc Genomewide association analysis of coronary artery disease
    Nilesh J Samani
    University of Leicester, Leicester, United Kingdom
    N Engl J Med 357:443-53. 2007
    ..Modern genotyping platforms permit a systematic search for inherited components of complex diseases. We performed a joint analysis of two genomewide association studies of coronary artery disease...
  23. doi request reprint Adjusting for bias and unmeasured confounding in Mendelian randomization studies with binary responses
    Tom M Palmer
    Department of Health Sciences, University of Leicester, UK
    Int J Epidemiol 37:1161-8. 2008
    ..When the linearity assumption between the variables does not hold the IV estimates will be biased. The extent of this bias in the phenotype-disease log odds ratio of a Mendelian randomization study is investigated...
  24. pmc A common variant in low-density lipoprotein receptor-related protein 6 gene (LRP6) is associated with LDL-cholesterol
    Maciej Tomaszewski
    Department of Cardiovascular Sciences, University of Leicester, Clinical Sciences Wing, Glenfield Hospital, Leicester, LE3 9QP, UK
    Arterioscler Thromb Vasc Biol 29:1316-21. 2009
    ..We hypothesized that common variants in LRP6 could predispose subjects to elevated LDL-cholesterol (LDL-C)...
  25. ncbi request reprint Coronary artery disease-associated locus on chromosome 9p21 and early markers of atherosclerosis
    Nilesh J Samani
    Department of Cardiovascular Sciences, University of Leicester, UK
    Arterioscler Thromb Vasc Biol 28:1679-83. 2008
    ..The effect of the locus on early markers of atherosclerosis is unknown. We examined its association with carotid intima-media thickness (CIMT) and brachial flow-mediated dilatation (FMD)...
  26. pmc Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants
    Paul R Burton
    Genetic Epidemiology Group, Department of Health Sciences, University of Leicester, Adrian Building, University Road, Leicester LE1 7RH, UK
    Nat Genet 39:1329-37. 2007
    ....
  27. pmc Common variants near TERC are associated with mean telomere length
    Veryan Codd
    Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester, UK
    Nat Genet 42:197-9. 2010
    ..Each copy of the minor allele of rs12696304 was associated with an approximately 75-base-pair reduction in mean telomere length, equivalent to approximately 3.6 years of age-related telomere-length attrition...
  28. ncbi request reprint Covariance components models for longitudinal family data
    Paul R Burton
    Biostatistics and Genetic Epidemiology, Department of Health Sciences, Institute of Genetics, University of Leicester, UK
    Int J Epidemiol 34:1063-77; discussion 1077-9. 2005
    ..We demonstrate the efficacy of our methods using a range of simulated data analyses, and illustrate its practical application to longitudinal blood pressure data measured in families from the Framingham Heart Study...
  29. ncbi request reprint Beyond "misunderstanding": written information and decisions about taking part in a genetic epidemiology study
    Mary Dixon-Woods
    University of Leicester, Leicester, UK
    Soc Sci Med 65:2212-22. 2007
    ..These questions need to be addressed through engagement and dialogue between the research, research participants, social science, and ethics communities...
  30. doi request reprint Pharmacogenetic interactions and their potential effects on genetic analyses of blood pressure
    Nicholas Masca
    Department of Health Sciences, University of Leicester, University Road, Leicester, U K
    Stat Med 30:769-83. 2011
    ..This work demonstrates the potential influence of pharmacogenetic interactions in genetic analyses of BP...
  31. ncbi request reprint Genomic copy number variation, human health, and disease
    Louise V Wain
    Department of Health Sciences and Department of Genetics, University of Leicester, Leicester, UK
    Lancet 374:340-50. 2009
    ..We review efforts to map copy number variants and discuss present and future prospects for assessment of their relation to human health and disease...
  32. pmc Genome-wide association study identifies five loci associated with lung function
    Emmanouela Repapi
    Departments of Health Sciences and Genetics, Adrian Building, University of Leicester, Leicester, UK
    Nat Genet 42:36-44. 2010
    ..These associations offer mechanistic insight into pulmonary function regulation and indicate potential targets for interventions to alleviate respiratory disease...
  33. pmc Longitudinal variance components models for systolic blood pressure, fitted using Gibbs sampling
    Katrina J Scurrah
    Institute of Genetics and Department of Epidemiology and Public Health, University of Leicester, 22 28 Princess Road, Leicester, LE1 6TP, United Kingdom
    BMC Genet 4:S25. 2003
    ..The first-stage analysis provided evidence for general genetic effects on both the baseline and slope of blood pressure, and the linkage analysis found evidence of several genes, again for both baseline and slope...
  34. pmc Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure
    Louise V Wain
    Department of Health Sciences, University of Leicester, Leicester, UK
    Nat Genet 43:1005-11. 2011
    ..These findings suggest new genetic pathways underlying blood pressure variation, some of which may differentially influence SBP and DBP...
  35. pmc The role of copy number variation in susceptibility to amyotrophic lateral sclerosis: genome-wide association study and comparison with published loci
    Louise V Wain
    Department of Health Sciences, University of Leicester, Leicester, United Kingdom
    PLoS ONE 4:e8175. 2009
    ....
  36. pmc Whole Exome Re-Sequencing Implicates CCDC38 and Cilia Structure and Function in Resistance to Smoking Related Airflow Obstruction
    Louise V Wain
    University of Leicester, Department of Health Sciences, Leicester, United Kingdom
    PLoS Genet 10:e1004314. 2014
    ..We suggest that genetic influences on the development or function of cilia in the bronchial epithelium may affect growth of cilia or the extent of damage caused by tobacco smoke. ..
  37. ncbi request reprint An integrated approach to the meta-analysis of genetic association studies using Mendelian randomization
    Cosetta Minelli
    Centre for Biostatistics and Genetic Epidemiology, Department of Health Sciences, Leicester Medical School, University of Leicester, 22 28 Princess Road West, Leicester LE1 6TP, United Kingdom
    Am J Epidemiol 160:445-52. 2004
    ..Serious biases may arise if the assumptions behind the analysis based on Mendelian randomization are not met...
  38. doi request reprint Genome-wide association studies in lung disease
    Maria Soler Artigas
    Department of Health Sciences, University of Leicester, Leicester LE1 7RH, UK
    Thorax 67:271-3, 280. 2012
    ..This paper summarises the key features of a GWAS, references some recent findings and discusses how the chest physician can interpret the validity and utility of future GWAS and related studies...
  39. pmc Association between lipid profile and circulating concentrations of estrogens in young men
    Maciej Tomaszewski
    Department of Cardiovascular Sciences, University of Leicester, Leicester, UK
    Atherosclerosis 203:257-62. 2009
    ..Unlike androgens, estrogens were not extensively investigated in relation to cardiovascular phenotypes in men...
  40. pmc FGF21 signalling pathway and metabolic traits - genetic association analysis
    Bernhard M Kaess
    Department of Cardiovascular Sciences, University of Leicester, Glenfield General Hospital, Leicester, UK
    Eur J Hum Genet 18:1344-8. 2010
    ..017). The direction of allelic effect of rs2071616 upon LDL-C was consistent in all examined populations. These data show that common genetic variations in FGFR2 may be associated with LDL-C in subjects of white European ancestry...
  41. ncbi request reprint Key concepts in genetic epidemiology
    Paul R Burton
    Department of Health Sciences, University of Leicester, Leicester, UK
    Lancet 366:941-51. 2005
    ..We anticipate that, depending on their professional background and specialist knowledge, some readers will wish to skip some of this article...
  42. pmc Copy number variation of the beta-defensin genes in europeans: no supporting evidence for association with lung function, chronic obstructive pulmonary disease or asthma
    Louise V Wain
    Department of Health Sciences, University of Leicester, Leicester, United Kingdom
    PLoS ONE 9:e84192. 2014
    ..Suboptimal measurement of copy number can lead to spurious associations. Further beta-defensin copy number measurement in larger sample sizes of COPD cases and children with asthma are needed. ..
  43. doi request reprint Copy number variation
    Louise V Wain
    Department of Health Sciences, University of Leicester, Leicester, UK
    Methods Mol Biol 713:167-83. 2011
    ..The study of CNV and its effects on human health and disease therefore present a dynamic and exciting challenge for researchers in the field of genetic epidemiology...
  44. ncbi request reprint The Y chromosome effect on blood pressure in two European populations
    Fadi J Charchar
    British Heart Foundation Blood Pressure Group, Department of Medicine, University of Glasgow, United Kingdom
    Hypertension 39:353-6. 2002
    ..The polymorphism in the aldosterone synthase gene may interact with the Y chromosome to increase the odds of an individual's developing higher BP...
  45. ncbi request reprint Association of the human Y chromosome with cholesterol levels in the general population
    Fadi J Charchar
    BHF Glasgow Cardiovascular Research Centre, Division of Cardiovascular and Medical Sciences, University of Glasgow, Western Infirmary, Glasgow G11 6NT, United Kingdom
    Arterioscler Thromb Vasc Biol 24:308-12. 2004
    ..Males are at higher risk of cardiovascular diseases than females. The aim of the study was to test whether the potential of the Y chromosome to affect cardiovascular risk could be attributed to its influence on lipids...
  46. ncbi request reprint Essential hypertension and beta2-adrenergic receptor gene: linkage and association analysis
    Maciej Tomaszewski
    British Heart Foundation Blood Pressure Group, Department of Medicine and Therapeutics, University of Glasgow, Glasgow, United Kingdom
    Hypertension 40:286-91. 2002
    ..The detailed analysis of 3 single nucleotide polymorphisms does not support the role of the beta2-adrenergic receptor gene as a major causative gene for the detected linkage...
  47. ncbi request reprint Y is there a risk to being male?
    Fadi J Charchar
    BHF Glasgow Cardiovascular Research Centre, Division of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow G11 6NT, Scotland, UK
    Trends Endocrinol Metab 14:163-8. 2003
    ....
  48. ncbi request reprint Serum C-reactive protein and lipids in ultra-Marathon runners
    Maciej Tomaszewski
    British Heart Foundation Glasgow Cardiovascular Research Centre, Division of Cardiovascular and Medical Sciences, and Department of Pathological Biochemistry, University of Glasgow, Glasgow, United Kingdom
    Am J Cardiol 94:125-6. 2004
    ..This exercise-induced reduction in low-density lipoprotein cholesterol was independent of the decrease in C-reactive protein levels...
  49. ncbi request reprint Cerebral hemodynamics and investigations of cerebral blood flow regulation
    Wojciech Rudzinski
    Department of Radiology, Division of Neuroradiology of the University of Pennsylvania, Philadelphia, PA 19104, USA
    Nucl Med Rev Cent East Eur 10:29-42. 2007
    ....
  50. ncbi request reprint [Fibroblast growth factor 1 gene and essential hypertension--from the chromosomal region linked to blood pressure to renal glomerulus]
    Ewa Zukowska-Szczechowska
    Katedra i Klinika Chorob Wewnetrznych, Diabetologii i Nefrologii SUM, Szpital Kliniczny nr 1, ul 3 Maja 13 15, 41 800 Zabrze
    Kardiol Pol 66:227-8. 2008
  51. ncbi request reprint Fibroblast growth factor 1 gene and hypertension: from the quantitative trait locus to positional analysis
    Maciej Tomaszewski
    British Heart Foundation Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UK
    Circulation 116:1915-24. 2007
    ..The distal portion of the long arm of chromosome 5 is linked to hypertension and contains functional candidate blood pressure-regulating genes...
  52. ncbi request reprint Epistatic interaction between beta2-adrenergic receptor and neuropeptide Y genes influences LDL-cholesterol in hypertension
    Maciej Tomaszewski
    British Heart Foundation Glasgow Cardiovascular Research Centre, Division of Cardiovascular and Medical Sciences, University of Glasgow, Western Infirmary, Glasgow G11 6NT, United Kingdom
    Hypertension 44:689-94. 2004
    ....
  53. ncbi request reprint Genetic information in the diagnosis and treatment of hypertension
    Maciej Tomaszewski
    Curr Hypertens Rep 8:309-16. 2006
    ....
  54. ncbi request reprint Letter re: Inflammation and lipoprotein changes with protracted exercise
    Maciej Tomaszewski
    J Clin Endocrinol Metab 90:4981. 2005