Jonathan H Tobias

Summary

Affiliation: University of Bristol
Country: UK

Publications

  1. pmc Habitual levels of high, but not moderate or low, impact activity are positively related to hip BMD and geometry: results from a population-based study of adolescents
    Kevin Deere
    Musculoskeletal Research Unit, School of Clinical Sciences, University of Bristol, Bristol, UK
    J Bone Miner Res 27:1887-95. 2012
  2. pmc The association between insulin levels and cortical bone: findings from a cross-sectional analysis of pQCT parameters in adolescents
    Adrian Sayers
    Musculoskeletal Research Unit, School of Clinical Sciences, University of Bristol, Bristol, United Kingdom
    J Bone Miner Res 27:610-8. 2012
  3. pmc High impact activity is related to lean but not fat mass: findings from a population-based study in adolescents
    Kevin Deere
    Musculoskeletal Research Unit, School of Clinical Sciences, University of Bristol, Bristol, UK
    Int J Epidemiol 41:1124-31. 2012
  4. pmc 25-Hydroxyvitamin-D3 levels are positively related to subsequent cortical bone development in childhood: findings from a large prospective cohort study
    A Sayers
    Musculoskeletal Research Unit, School of Clinical Sciences, University of Bristol, Bristol, UK
    Osteoporos Int 23:2117-28. 2012
  5. pmc The high bone mass phenotype is characterised by a combined cortical and trabecular bone phenotype: findings from a pQCT case-control study
    Celia L Gregson
    Musculoskeletal Research Unit, University of Bristol, Avon Orthopaedic Centre, Southmead Hospital, Bristol BS10 5NB, UK
    Bone 52:380-8. 2013
  6. pmc Distinct relationships of intramuscular and subcutaneous fat with cortical bone: findings from a cross-sectional study of young adult males and females
    K Deere
    Musculoskeletal Research Unit, School of Clinical Sciences, University of Bristol, Bristol BS10 5NB, United Kingdom
    J Clin Endocrinol Metab 98:E1041-9. 2013
  7. ncbi request reprint Joint hypermobility is a risk factor for musculoskeletal pain during adolescence: findings of a prospective cohort study
    Jonathan H Tobias
    University of Bristol and Avon Orthopaedic Centre, Southmead Hospital, Bristol, UK
    Arthritis Rheum 65:1107-15. 2013
  8. pmc A cross-sectional study of the relationship between cortical bone and high-impact activity in young adult males and females
    K Deere
    Musculoskeletal Research Unit, School of Clinical Sciences, University of Bristol, Avon Orthopaedic Centre, Southmead Hospital, Bristol BS10 5NB, United Kingdom
    J Clin Endocrinol Metab 97:3734-43. 2012
  9. pmc Gender differences in the ratio between humerus width and length are established prior to puberty
    E M Clark
    Community Based Medicine, University of Bristol, Bristol, UK
    Osteoporos Int 18:463-70. 2007
  10. pmc Estimated maternal ultraviolet B exposure levels in pregnancy influence skeletal development of the child
    Adrian Sayers
    Academic Rheumatology, Department of Clinical Science at North Bristol, University of Bristol, Bristol BS2 8HW, United Kingdom
    J Clin Endocrinol Metab 94:765-71. 2009

Detail Information

Publications51

  1. pmc Habitual levels of high, but not moderate or low, impact activity are positively related to hip BMD and geometry: results from a population-based study of adolescents
    Kevin Deere
    Musculoskeletal Research Unit, School of Clinical Sciences, University of Bristol, Bristol, UK
    J Bone Miner Res 27:1887-95. 2012
    ..Hence, PA may only strengthen lower limb bones in adolescents, and possibly adults, if this comprises high-impact activity...
  2. pmc The association between insulin levels and cortical bone: findings from a cross-sectional analysis of pQCT parameters in adolescents
    Adrian Sayers
    Musculoskeletal Research Unit, School of Clinical Sciences, University of Bristol, Bristol, United Kingdom
    J Bone Miner Res 27:610-8. 2012
    ..However, an inverse association between insulin and both PC and BMD(C) persisted after adjusting for all body composition variables, suggesting insulin also acts to inhibit bone development via additional pathways yet to be elucidated...
  3. pmc High impact activity is related to lean but not fat mass: findings from a population-based study in adolescents
    Kevin Deere
    Musculoskeletal Research Unit, School of Clinical Sciences, University of Bristol, Bristol, UK
    Int J Epidemiol 41:1124-31. 2012
    ..We wished to assess an alternative approach using an accelerometer calibrated according to impact loading...
  4. pmc 25-Hydroxyvitamin-D3 levels are positively related to subsequent cortical bone development in childhood: findings from a large prospective cohort study
    A Sayers
    Musculoskeletal Research Unit, School of Clinical Sciences, University of Bristol, Bristol, UK
    Osteoporos Int 23:2117-28. 2012
    ....
  5. pmc The high bone mass phenotype is characterised by a combined cortical and trabecular bone phenotype: findings from a pQCT case-control study
    Celia L Gregson
    Musculoskeletal Research Unit, University of Bristol, Avon Orthopaedic Centre, Southmead Hospital, Bristol BS10 5NB, UK
    Bone 52:380-8. 2013
    ..In contrast to the radius, neither trabecular nor cortical BMD declined with age in the tibia of HBM cases, suggesting attenuation of age-related bone loss in weight-bearing limbs contributes to the observed bone phenotype...
  6. pmc Distinct relationships of intramuscular and subcutaneous fat with cortical bone: findings from a cross-sectional study of young adult males and females
    K Deere
    Musculoskeletal Research Unit, School of Clinical Sciences, University of Bristol, Bristol BS10 5NB, United Kingdom
    J Clin Endocrinol Metab 98:E1041-9. 2013
    ..Intracellular fat within muscle and visceral tissue has been suggested to adversely influence bone development...
  7. ncbi request reprint Joint hypermobility is a risk factor for musculoskeletal pain during adolescence: findings of a prospective cohort study
    Jonathan H Tobias
    University of Bristol and Avon Orthopaedic Centre, Southmead Hospital, Bristol, UK
    Arthritis Rheum 65:1107-15. 2013
    ..To determine whether joint hypermobility (JH) in childhood is a risk factor for the subsequent development of musculoskeletal pain...
  8. pmc A cross-sectional study of the relationship between cortical bone and high-impact activity in young adult males and females
    K Deere
    Musculoskeletal Research Unit, School of Clinical Sciences, University of Bristol, Avon Orthopaedic Centre, Southmead Hospital, Bristol BS10 5NB, United Kingdom
    J Clin Endocrinol Metab 97:3734-43. 2012
    ..The factors that govern skeletal responses to physical activity remain poorly understood...
  9. pmc Gender differences in the ratio between humerus width and length are established prior to puberty
    E M Clark
    Community Based Medicine, University of Bristol, Bristol, UK
    Osteoporos Int 18:463-70. 2007
    ....
  10. pmc Estimated maternal ultraviolet B exposure levels in pregnancy influence skeletal development of the child
    Adrian Sayers
    Academic Rheumatology, Department of Clinical Science at North Bristol, University of Bristol, Bristol BS2 8HW, United Kingdom
    J Clin Endocrinol Metab 94:765-71. 2009
    ..Relationships between vitamin D exposure of the mother in pregnancy and skeletal development of the child are poorly understood...
  11. ncbi request reprint Effect of an estrogen receptor-alpha intron 4 polymorphism on fat mass in 11-year-old children
    J H Tobias
    Rheumatology Unit, Bristol Royal Infirmary, Bristol, UK
    J Clin Endocrinol Metab 92:2286-91. 2007
    ..Polymorphisms in the ESR1 gene encoding estrogen receptor (ER)-alpha may be associated with fat mass in adults...
  12. ncbi request reprint Estrogen receptor alpha regulates area-adjusted bone mineral content in late pubertal girls
    J H Tobias
    Clinical Science at South Bristol, University of Bristol, Bristol, United Kingdom
    J Clin Endocrinol Metab 92:641-7. 2007
    ..Whether the action of estrogen in skeletal development depends on estrogen receptor alpha as encoded by the ESR1 gene is unknown...
  13. ncbi request reprint Use of clinical risk factors to identify postmenopausal women with vertebral fractures
    J H Tobias
    Department of Clinical Science at South Bristol, University of Bristol, Bristol, BS2 8HW, UK
    Osteoporos Int 18:35-43. 2007
    ..Here, we investigated whether a stronger relationship exists with prevalent VF when conventional risk factors are combined with additional information obtained from detailed one-to-one assessment...
  14. ncbi request reprint Bone mass in childhood is related to maternal diet in pregnancy
    J H Tobias
    Clinical Science at South Bristol, Bristol, UK
    Osteoporos Int 16:1731-41. 2005
    ..Our observation that constituents of maternal diet are related to DXA measures at age 9 is consistent with the hypothesis that the trajectory of bone development in childhood is programmed by early life factors...
  15. ncbi request reprint Novel therapeutic targets in osteoporosis
    J H Tobias
    Rheumatology Unit, University of Bristol, UK
    Expert Opin Ther Targets 6:41-56. 2002
    ..However, it is anticipated that these will provide the basis for significant numbers of new therapies for osteoporosis in the foreseeable future...
  16. ncbi request reprint Analysis of the contribution of dydrogesterone to bone turnover changes in postmenopausal women commencing hormone replacement therapy
    J H Tobias
    Rheumatology Unit, University of Bristol Division of Medicine, Rowett Research Institute, Aberdeen, United Kingdom AB21 9SB
    J Clin Endocrinol Metab 86:1194-8. 2001
    ..These results suggest that gestagens may reduce estrogen's beneficial effects on the skeleton of postmenopausal women, as assessed over the first 8 weeks of replacement therapy...
  17. ncbi request reprint PTH/PTHrP activity and the programming of skeletal development in utero
    Jonathan H Tobias
    Department of Clinical Sciences at South Bristol, University of Bristol, Bristol, United Kingdom
    J Bone Miner Res 19:177-82. 2004
    ....
  18. ncbi request reprint At the crossroads of skeletal responses to estrogen and exercise
    Jonathan H Tobias
    Rheumatology Unit, Bristol Royal Infirmary, BS2 8HW, Bristol, UK
    Trends Endocrinol Metab 14:441-3. 2003
    ..In view of previous findings that estrogen deficiency leads to a fall in ERalpha numbers, postmenopausal bone loss might result from the impaired response of bone to mechanical strain caused by deficient ERalpha signalling...
  19. pmc Adipose tissue stimulates bone growth in prepubertal children
    E M Clark
    Rheumatology Unit, Bristol Royal Infirmary, Bristol BS2 8HW, United Kingdom
    J Clin Endocrinol Metab 91:2534-41. 2006
    ..Fat mass represents a positive influence on bone mass in adults, independently of other factors such as lean mass, but whether a similar action occurs in children is unclear...
  20. pmc How does body fat influence bone mass in childhood? A Mendelian randomization approach
    Nicholas J Timpson
    MRC Centre for Causal Analyses in Translational Epidemiology, Department of Social Medicine, University of Bristol, Bristol, UK
    J Bone Miner Res 24:522-33. 2009
    ....
  21. pmc Epidemiology of generalized joint laxity (hypermobility) in fourteen-year-old children from the UK: a population-based evaluation
    Jacqui Clinch
    Bristol Royal Hospital for Children, University of Bristol, Bristol, UK
    Arthritis Rheum 63:2819-27. 2011
    ..The present study was undertaken to describe the point prevalence and pattern of hypermobility in 14-year-old children from a population-based cohort...
  22. ncbi request reprint Insights into the programming of bone development from the Avon Longitudinal Study of Parents and Children (ALSPAC)
    Colin D Steer
    Centre for Child and Adolescent Health and Academic Rheumatology, Southmead Hospital, University of Bristol, United Kingdom
    Am J Clin Nutr 94:1861S-1864S. 2011
    ..Together, these results confirm that there is a relation between bone development in childhood and several proxy measures for nutritional status in utero...
  23. ncbi request reprint Mice rendered severely deficient in megakaryocytes through targeted gene deletion of the thrombopoietin receptor c-Mpl have a normal skeletal phenotype
    Mark J Perry
    Anatomy and Clinical Sciences North Bristol, University of Bristol, Southwell Street, Bristol, BS2 8EJ, UK
    Calcif Tissue Int 81:224-31. 2007
    ..These results represent the first in vivo evidence that severe megakaryocyte deficiency does not affect bone formation, suggesting that this process is not dependent on normal megakaryocyte number...
  24. ncbi request reprint Impaired growth plate function in bmp-6 null mice
    Mark J Perry
    Department of Clinical Science North Bristol, Bristol University, Bristol, UK
    Bone 42:216-25. 2008
    ....
  25. ncbi request reprint Transcriptional regulation of a BMP-6 promoter by estrogen receptor alpha
    Delia B Ong
    Academic Rheumatology, University of Bristol, Bristol, United Kingdom
    J Bone Miner Res 19:447-54. 2004
    ....
  26. pmc Fat mass exerts a greater effect on cortical bone mass in girls than boys
    Adrian Sayers
    Academic Rheumatology, Avon Orthopaedic Centre, Southmead Hospital, Bristol BS10 5NB, United Kingdom
    J Clin Endocrinol Metab 95:699-706. 2010
    ....
  27. pmc Investigation of sex differences in hip structure in peripubertal children
    Adrian Sayers
    Academic Rheumatology, Clinical Science at North Bristol, University of Bristol, and Avon Orthopaedic Centre, Southmead Hospital, Bristol BS10 5NB, United Kingdom
    J Clin Endocrinol Metab 95:3876-83. 2010
    ..There is evidence that sex differences in hip structure are increased during puberty, possibly as a consequence of associated changes in body composition...
  28. doi request reprint IL-6 may modulate the skeletal response to glucocorticoids during exacerbations of inflammatory bowel disease
    Muhammed Kriel
    Clinical Science at South Bristol, University of Bristol, Bristol, UK
    Calcif Tissue Int 86:375-81. 2010
    ..In conclusion, IL-6 is elevated in active IBD and may protect against GC-induced suppression of bone formation via a mechanism which appears to be independent of systemic GC sensitivity...
  29. doi request reprint Potential use of an estrogen-glucocorticoid receptor chimera as a drug screen for tissue selective estrogenic activity
    Benit S Maru
    Laboratory for Integrated Neurosciences and Endocrinology, University of Bristol, UK
    Bone 44:102-12. 2009
    ..Further studies utilising this system are justified to explore the mechanistic basis for estrogenic stimulation of osteoblast activity, and to identify newer SERMs capable of targeting this activity...
  30. pmc Friend or foe: high bone mineral density on routine bone density scanning, a review of causes and management
    Celia L Gregson
    Musculoskeletal Research Unit, School of Clinical Sciences, University of Bristol, Bristol, UK
    Rheumatology (Oxford) 52:968-85. 2013
    ....
  31. ncbi request reprint Estrogen receptor-alpha dependency of estrogen's stimulatory action on cancellous bone formation in male mice
    Kathleen E McDougall
    Academic Rheumatology, University of Bristol, Bristol BS2 8HW, United Kingdom
    Endocrinology 144:1994-9. 2003
    ..Taken together, our results suggest that estrogen stimulates bone formation in mouse long bones via a mechanism that requires the presence of full-length ER alpha possessing activation function-1...
  32. pmc Parental smoking during pregnancy and offspring bone mass at age 10 years: findings from a prospective birth cohort
    C Macdonald-Wallis
    MRC Centre for Causal Analyses in Translational Epidemiology, Department of Social Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, UK
    Osteoporos Int 22:1809-19. 2011
    ..This appears to be due to familial factors related to parental smoking influencing increased offspring adiposity rather than a direct intrauterine effect...
  33. pmc Association between bone density and fractures in children: a systematic review and meta-analysis
    E M Clark
    Department of Community Based Medicine, University of Bristol, Bristol, United Kingdom
    Pediatrics 117:e291-7. 2006
    ..The objective of this article was to systematically review all published studies that investigated the association between bone density and fractures in children...
  34. pmc OPG and RANK polymorphisms are both associated with cortical bone mineral density: findings from a metaanalysis of the Avon longitudinal study of parents and children and gothenburg osteoporosis and obesity determinants cohorts
    L Paternoster
    Medical Research Council Centre for Causal Analyses in Translational Epidemiology, Department of Social Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, United Kingdom
    J Clin Endocrinol Metab 95:3940-8. 2010
    ..Several single-nucleotide polymorphisms (SNPs) have been reliably associated with areal bone mineral density (aBMD) in genome-wide association studies of mostly older subjects...
  35. ncbi request reprint Characterisation of the temporal sequence of osteoblast gene expression during estrogen-induced osteogenesis in female mice
    A Plant
    Rheumatology Unit, University of Bristol, Division of Medicine, Bristol, United Kingdom
    J Cell Biochem 82:683-91. 2001
    ....
  36. ncbi request reprint Tamoxifen stimulates cancellous bone formation in long bones of female mice
    M J Perry
    Department of Anatomy, University of Bristol, Bristol, United Kingdom
    Endocrinology 146:1060-5. 2005
    ....
  37. ncbi request reprint Does estrogen stimulate osteoblast function in postmenopausal women?
    J H Tobias
    Rheumatology Unit, University of Bristol Division of Medicine, Bristol Royal Infirmary, UK
    Bone 24:121-4. 1999
    ....
  38. pmc A meta-analysis of the associations between common variation in the PDE8B gene and thyroid hormone parameters, including assessment of longitudinal stability of associations over time and effect of thyroid hormone replacement
    Peter N Taylor
    Henry Wellcome Laboratories for Integrative Neurosciences and Endocrinology, University of Bristol, Bristol BS1 3NY, UK
    Eur J Endocrinol 164:773-80. 2011
    ..Furthermore, the stability of the association has not been examined in longitudinal studies or in patients on levothyroxine (l-T(4))...
  39. ncbi request reprint Estrogen-induced osteogenesis in mice is associated with the appearance of Cbfa1-expressing bone marrow cells
    Andrea Plant
    Rheumatology Unit, University of Bristol Division of Medicine, Bristol Royal Infirmary, Bristol BS2 8HW, United Kingdom
    J Cell Biochem 84:285-94. 2002
    ....
  40. ncbi request reprint Role of endothelial nitric oxide synthase in estrogen-induced osteogenesis
    A Samuels
    Rheumatology Unit, University of Bristol Division of Medicine, Bristol, UK
    Bone 29:24-9. 2001
    ..Taken together, our results suggest that eNOS plays a role in mediating estrogen-induced bone formation in intact female mice, possibly as a consequence of posttranscriptional regulation of eNOS activity by estrogen...
  41. ncbi request reprint Effects of combination therapy with PTH and 17beta-estradiol on long bones of female mice
    A Samuels
    University of Bristol Division of Medicine, UK
    Calcif Tissue Int 69:164-70. 2001
    ..We conclude that PTH and E2 exert an additive effect on bone mass in long bones of female mice, possibly reflecting an ability of PTH to oppose E2-induced suppression of periosteal bone formation...
  42. ncbi request reprint Increased bone morphogenetic protein-6 expression in mouse long bones after estrogen administration
    Andrea Plant
    Rheumatology Unit, University of Bristol Division of Medicine, United Kingdom
    J Bone Miner Res 17:782-90. 2002
    ..These findings raise the possibility that BMP-6 serves as a paracrine mediator of estrogen's osteogenic action in mice...
  43. ncbi request reprint Effect of a case-finding strategy for osteoporosis on bisphosphonate prescribing in primary care
    L S Morrison
    Rheumatology Unit, Clinical Science at South Bristol, University of Bristol, Bristol, UK
    Osteoporos Int 16:71-7. 2005
    ..In contrast, the overall rate of bisphosphonate prescribing is unaffected by this intervention...
  44. pmc Habitual levels of vigorous, but not moderate or light, physical activity is positively related to cortical bone mass in adolescents
    A Sayers
    Musculoskeletal Research Unit, School of Clinical Sciences, University of Bristol, Bristol BS10 5NB, United Kingdom
    J Clin Endocrinol Metab 96:E793-802. 2011
    ..The intensity of habitual physical activity (PA) needed to affect skeletal development in childhood is currently unclear...
  45. ncbi request reprint Estrogen-induced osteogenesis in intact female mice lacking ERbeta
    K E McDougall
    Academic Rheumatology, University of Bristol, Bristol BS2 8HW, United Kingdom
    Am J Physiol Endocrinol Metab 283:E817-23. 2002
    ..We conclude that, although ERbeta acts as a negative modulator of cortical modeling, this isoform does not appear to contribute to high-dose estrogen's ability to induce new cancellous bone formation in mouse long bones...
  46. ncbi request reprint Rapid hip bone loss in active Crohn's disease patients receiving short-term corticosteroid therapy
    J H Tobias
    Department of Clinical Science at South Bristol, University of Bristol, Bristol, UK
    Aliment Pharmacol Ther 20:951-7. 2004
    ..Uncertainty over whether corticosteroids cause bone loss in patients with Crohn's disease may reflect their short, intermittent use...
  47. pmc A common variant of HMGA2 is associated with adult and childhood height in the general population
    Michael N Weedon
    Genetics of Complex Traits, Institute of Biomedical and Clinical Science, Peninsula Medical School, Magdalen Road, Exeter EX1 2LU, UK
    Nat Genet 39:1245-50. 2007
    ..There are few examples of common genetic variants reproducibly associated with human quantitativetraits; these results represent, to our knowledge, the first consistently replicated association with adult and childhood height...
  48. pmc The effect of LRP5 polymorphisms on bone mineral density is apparent in childhood
    M Audrey Koay
    Institute of Musculoskeletal Sciences, University of Oxford, Botnar Research Centre, Nuffield Orthopaedic Centre, Windmill Road, Headington, Oxford, OX3 7LD, UK
    Calcif Tissue Int 81:1-9. 2007
    ..These results indicate that LRP5 influences volumetric bone density in childhood, possibly through effects on trabecular bone formation...
  49. pmc Common variants near MC4R are associated with fat mass, weight and risk of obesity
    Ruth J F Loos
    MRC Epidemiology Unit, Addenbrooke s Hospital, Cambridge CB2 0QQ, UK
    Nat Genet 40:768-75. 2008
    ....
  50. pmc A novel member of the SAF (scaffold attachment factor)-box protein family inhibits gene expression and induces apoptosis
    Ching Wan Chan
    Henry Wellcome Laboratories for Integrative Neurosciences and Endocrinology, Dorothy Hodgkin Building, Whitson Street, Bristol BS1 3NY, UK
    Biochem J 407:355-62. 2007
    ..While indicating a crucial role for SLTM in cellular function, these results also emphasize the need for caution when interpreting phenotypic changes associated with manipulation of protein expression levels...