Research Topics
| Stephen TischSummaryAffiliation: University College London Country: UK Publications
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Detail Information
Publications
Effect of electrode contact location on clinical efficacy of pallidal deep brain stimulation in primary generalised dystoniaS Tisch
Unit of Functional Neurosurgery, Sobell Department, Institute of Neurology, University College London, Box 146, 8 11 Queen Square, London WC1N 3BG, UK
J Neurol Neurosurg Psychiatry 78:1314-9. 2007..To determine the effect of electrode contact location on efficacy of bilateral globus pallidus internus (GPi) deep brain stimulation (DBS) for primary generalised dystonia (PGD). Subjects and..
Cortical evoked potentials from pallidal stimulation in patients with primary generalized dystoniaStephen Tisch
Unit of Functional Neurosurgery, Sobell Department Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London, United Kingdom
Mov Disord 23:265-73. 2008..Because the EP is larger and more consistently present with stimulation of posteroventral GPi than GPe, it may provide a physiological tool to identify contacts within the optimal surgical target...- The physiological effects of pallidal deep brain stimulation in dystoniaStephen Tisch
Unit of Functional Neurosurgery, Sobell Department of Motor Neuroscience, Institute of Neurology, London WC1N 3BG, UK
IEEE Trans Neural Syst Rehabil Eng 15:166-72. 2007.... - Pallidal stimulation modifies after-effects of paired associative stimulation on motor cortex excitability in primary generalised dystoniaStephen Tisch
Unit of Functional Neurosurgery, Sobell Department Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, Box 146 8 11 Queen Square, London WC1N 3BG, UK
Exp Neurol 206:80-5. 2007..To determine the effect of globus pallidus internus (GPi) deep brain stimulation (DBS) on motor cortex plasticity in patients with primary generalised dystonia... - Deep brain stimulation effects in dystonia: time course of electrophysiological changes in early treatmentDiane Ruge
Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, University College London, London, United Kingdom
Mov Disord 26:1913-21. 2011..Clinical benefit is delayed because engrams of abnormal movement persist and take time to normalize. Our observations suggest that plasticity may be a driver of long-term therapeutic effects of deep brain stimulation in dystonia... - Excessive synchronization of basal ganglia neurons at 20 Hz slows movement in Parkinson's diseaseChiung Chu Chen
Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, UK
Exp Neurol 205:214-21. 2007..This effect was frequency selective. The current data provide proof of the principle that excessive beta synchrony within the basal ganglia-cortical loop may contribute to the slowing of movements in Parkinson's disease... - Intra-operative recordings of local field potentials can help localize the subthalamic nucleus in Parkinson's disease surgeryChiung Chu Chen
Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London WCIN 3BG, UK
Exp Neurol 198:214-21. 2006..Functional physiological localization of STN by the on-line spectral analysis of LFPs is quick to perform and may provide information directly relevant to the position of the electrode contact actually used for DBS... - Changes in blink reflex excitability after globus pallidus internus stimulation for dystoniaStephen Tisch
Unit of Functional Neurosurgery, Sobell Department Motor Neuroscience and Movement Disorders, Institute of Neurology, London, United Kingdom
Mov Disord 21:1650-5. 2006..We conclude that GPi DBS for PTD results in functional reorganization of the nervous system, which includes a long-term increase in brainstem inhibition... - Deep brain stimulation of the subthalamic nucleus: a two-edged swordChiung Chu Chen
Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, UK
Curr Biol 16:R952-3. 2006 
Effects of contact location and voltage amplitude on speech and movement in bilateral subthalamic nucleus deep brain stimulationElina Tripoliti
Unit of Functional Neurosurgery, Sobell Department, Institute of Neurology, London, United Kingdom
Mov Disord 23:2377-83. 2008....- Sensory timing cues improve akinesia of grasping movements in Parkinson's disease: a comparison to the effects of subthalamic nucleus stimulationDennis A Nowak
Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, London, United Kingdom
Mov Disord 21:166-72. 2006..This implies that subthalamic nucleus stimulation produces a generalized upregulation in the gain of all components of a movement without the subtlety of focused control that is required to normalize performance... - Oscillatory activity in the pedunculopontine area of patients with Parkinson's diseaseAlexandros G Androulidakis
Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, Queen Square, London, UK
Exp Neurol 211:59-66. 2008..The subcortical oscillations are coupled to cortical alpha activity and possibly allied to motor related attentional processes... - Cortico-cortical coupling in Parkinson's disease and its modulation by therapyPaul Silberstein
Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, UK
Brain 128:1277-91. 2005..This mechanistic similarity may underscore the strong clinical correlation between the therapeutic effects of these treatment modalities... - The beneficial effects of subthalamic nucleus stimulation on manipulative finger force control in Parkinson's diseaseDennis A Nowak
Sobell Department of Motor Neuroscience and Movements Disorders, Institute of Neurology, University of London, London, UK
Exp Neurol 193:427-36. 2005..STN stimulation enables Parkinson subjects to scale grip force more accurately to the loads arising from voluntary manipulation of hand-held objects... - Stereotactic localization of the human pedunculopontine nucleus: atlas-based coordinates and validation of a magnetic resonance imaging protocol for direct localizationLudvic Zrinzo
Unit of Functional Neurosurgery, Institute of Neurology, University College London, UK
Brain 131:1588-98. 2008..Direct MRI localization may allow greater individual accuracy than that afforded by atlas-based coordinates when localizing the human PPN and may be relevant to groups evaluating the clinical role of PPN DBS... - Can chronic subthalamic nucleus stimulation induce de novo tremor in Parkinson's disease?Stephane Thobois
Sobell Department of Motor Neurosciences and Movement Disorders, Unit of Functional Neurosurgery, Institute of Neurology, London, United Kingdom
Mov Disord 20:1066-9. 2005..We report on the cases of 3 patients who developed such modification of their parkinsonian symptomatology. Physiopathological hypotheses are discussed... - The basal ganglia: anatomy, physiology, and pharmacologyStephen Tisch
Sobell Department of Motor Neuroscience and Movement Disorders Institute of Neurology, Queen Square, London WC1N 3BG, United Kingdom
Psychiatr Clin North Am 27:757-99. 2004..Further work will elucidate this to a greater extent, but for now, it is clear that the basal ganglia form an important nexus in the binding of cognitive, limbic, and motor information into thought and action... - Variability of the subthalamic nucleus: the case for direct MRI guided targetingK Ashkan
Functional Neurosurgery Unit, Institute of Neurology, London, UK
Br J Neurosurg 21:197-200. 2007..The coordinates of the directly visualised STN were significantly different from those of the atlas target. Variability of the position of the STN may render direct visualisation a more accurate means of targeting this nucleus... - Suppression of beta oscillations in the subthalamic nucleus following cortical stimulation in humansL M F Doyle Gaynor
Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, UK
Eur J Neurosci 28:1686-95. 2008..The results may have implications for mechanisms underlying the reported therapeutic benefits of cortical stimulation... - Changes in forearm reciprocal inhibition following pallidal stimulation for dystoniaS Tisch
obell Department Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square London, United Kingdom
Neurology 66:1091-3. 2006..The authors conclude that pallidal DBS for dystonia results in functional reorganization of the nervous system, which includes a long-term increase in spinal inhibition... - Activation of the subthalamic region during emotional processing in Parkinson diseaseA A Kühn
Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, WC1N 3BG, UK
Neurology 65:707-13. 2005..To elucidate the involvement of the human subthalamic nucleus (STN) region in the processing or transmission of emotional information... - Severe tongue protrusion dystonia: clinical syndromes and possible treatmentS A Schneider
Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, UCL, London WC1N 3BG, UK
Neurology 67:940-3. 2006..Tongue protrusion dystonia is often unresponsive to oral drugs but may benefit from botulinum toxin injections into the genioglossus muscle. Bilateral deep brain pallidal stimulation was beneficial in two cases...