Cheryll Tickle

Summary

Affiliation: University of Dundee
Country: UK

Publications

  1. ncbi Limb development: an international model for vertebrate pattern formation
    C Tickle
    Department of Anatomy and Developmental Biology, University College London, United Kingdom
    Int J Dev Biol 44:101-8. 2000
  2. ncbi The contribution of chicken embryology to the understanding of vertebrate limb development
    C Tickle
    Division of Cell and Developmental Biology, University of Dundee, Dow Street, Dundee DD1 5EH, UK
    Mech Dev 121:1019-29. 2004
  3. ncbi Epithelial cell movements and interactions in limb, neural crest and vasculature
    C Tickle
    Department of Anatomy and Physiology, University of Dundee, The Wellcome Trust Building, Dow Street, Dundee, DD1 5EH, UK
    Curr Opin Genet Dev 9:455-60. 1999
  4. ncbi Molecular basis of vertebrate limb patterning
    Cheryll Tickle
    Division of Cell and Developmental Biology, School of Life Sciences, University of Dundee, Dundee, United Kingdom
    Am J Med Genet 112:250-5. 2002
  5. ncbi Morphological diversity: taking the spine out of three-spine stickleback
    Cheryll Tickle
    Division of Cell and Developmental Biology, Wellcome Trust Biocentre, University of Dundee, Dundee DD1 5EH, Scotland, UK
    Curr Biol 14:R422-4. 2004
  6. ncbi Vertebrate limb development--the early stages in chick and mouse
    C Tickle
    Division of Cell and Developmental Biology, School of Life Sciences, MSI WTB complex, University of Dundee, Dow Street, DD1 5EH, Dundee, UK
    Curr Opin Genet Dev 11:476-81. 2001
  7. ncbi The early history of the polarizing region: from classical embryology to molecular biology
    Cheryll Tickle
    Division of Cell and Developmental Biology, School of Life Sciences, University of Dundee, UK
    Int J Dev Biol 46:847-52. 2002
  8. ncbi Vertebrate limb development and possible clues to diversity in limb form
    Cheryll Tickle
    Division of Cell and Developmental Biology, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK
    J Morphol 252:29-37. 2002
  9. ncbi Patterning systems--from one end of the limb to the other
    C Tickle
    Division of Cell and Developmental Biology, School of Life Sciences, University of Dundee, Dundee DD15EH, United Kingdom
    Dev Cell 4:449-58. 2003
  10. ncbi Making digit patterns in the vertebrate limb
    Cheryll Tickle
    Division of Cell and Developmental Biology, School of Life Sciences, University of Dundee, Dow Street, Dundee, DD1 5EH, UK
    Nat Rev Mol Cell Biol 7:45-53. 2006

Collaborators

Detail Information

Publications63

  1. ncbi Limb development: an international model for vertebrate pattern formation
    C Tickle
    Department of Anatomy and Developmental Biology, University College London, United Kingdom
    Int J Dev Biol 44:101-8. 2000
    ..This has provided a direct link to genetics and thus to genes that cause human congenital limb defects...
  2. ncbi The contribution of chicken embryology to the understanding of vertebrate limb development
    C Tickle
    Division of Cell and Developmental Biology, University of Dundee, Dow Street, Dundee DD1 5EH, UK
    Mech Dev 121:1019-29. 2004
    ..The sequence of the chicken genome, together with other recently assembled chicken genomic resources, will present new opportunities for exploiting the ease of manipulating the limb...
  3. ncbi Epithelial cell movements and interactions in limb, neural crest and vasculature
    C Tickle
    Department of Anatomy and Physiology, University of Dundee, The Wellcome Trust Building, Dow Street, Dundee, DD1 5EH, UK
    Curr Opin Genet Dev 9:455-60. 1999
    ..Direct connections to molecular controls of cell migratory machinery have been shown for first time in neural crest migration. New unsuspected roles are emerging for ephrin ligand/Eph receptor signalling in vascular morphogenesis...
  4. ncbi Molecular basis of vertebrate limb patterning
    Cheryll Tickle
    Division of Cell and Developmental Biology, School of Life Sciences, University of Dundee, Dundee, United Kingdom
    Am J Med Genet 112:250-5. 2002
    ..Thus, the fields of embryology and clinical medicine increasingly converge. The next challenge will be to go back to animal models to begin to dissect how particular gene mutations lead to specific limb phenotypes...
  5. ncbi Morphological diversity: taking the spine out of three-spine stickleback
    Cheryll Tickle
    Division of Cell and Developmental Biology, Wellcome Trust Biocentre, University of Dundee, Dundee DD1 5EH, Scotland, UK
    Curr Biol 14:R422-4. 2004
    ..A gene already known to play a crucial developmental role in chick and mouse embryos has been fingered as a candidate for naturally occurring variation in three-spine stickleback anatomy...
  6. ncbi Vertebrate limb development--the early stages in chick and mouse
    C Tickle
    Division of Cell and Developmental Biology, School of Life Sciences, MSI WTB complex, University of Dundee, Dow Street, DD1 5EH, Dundee, UK
    Curr Opin Genet Dev 11:476-81. 2001
    ....
  7. ncbi The early history of the polarizing region: from classical embryology to molecular biology
    Cheryll Tickle
    Division of Cell and Developmental Biology, School of Life Sciences, University of Dundee, UK
    Int J Dev Biol 46:847-52. 2002
    ....
  8. ncbi Vertebrate limb development and possible clues to diversity in limb form
    Cheryll Tickle
    Division of Cell and Developmental Biology, School of Life Sciences, University of Dundee, Dundee DD1 5EH, UK
    J Morphol 252:29-37. 2002
    ..Possible mechanisms that could lead to variations in form, including limb reductions and limblessness, differences between fore- and hindlimbs, limb proportions, and interdigital webbing can be suggested...
  9. ncbi Patterning systems--from one end of the limb to the other
    C Tickle
    Division of Cell and Developmental Biology, School of Life Sciences, University of Dundee, Dundee DD15EH, United Kingdom
    Dev Cell 4:449-58. 2003
    ..This review describes current understanding of these regulatory mechanisms and how they form a framework for future analysis of limb patterning...
  10. ncbi Making digit patterns in the vertebrate limb
    Cheryll Tickle
    Division of Cell and Developmental Biology, School of Life Sciences, University of Dundee, Dow Street, Dundee, DD1 5EH, UK
    Nat Rev Mol Cell Biol 7:45-53. 2006
    ....
  11. ncbi Manipulations of PKA in chick limb development reveal roles in digit patterning including a positive role in Sonic Hedgehog signaling
    Eva Tiecke
    Cell and Developmental Biology, School of Life Sciences, University of Dundee, Dow Street, Dundee, DD1 5EH, UK
    Dev Biol 305:312-24. 2007
    ..PKA levels in the limb bud are high posteriorly and low anteriorly, suggesting that PKA activity may influence the outcome of Shh signaling in normal development...
  12. ncbi Interactions between FGF and Wnt signals and Tbx3 gene expression in mammary gland initiation in mouse embryos
    Maxwell C Eblaghie
    Division of Cell and Developmental Biology, Faculty of Life Sciences, Wellcome Trust Biocentre, University of Dundee, Scotland, UK
    J Anat 205:1-13. 2004
    ..These data, taken together with previous findings, suggest a model in which Tbx3 expression is induced and maintained in early gland initiation by both Wnt and Fgf signalling through FGFR1...
  13. ncbi The Talpid3 gene (KIAA0586) encodes a centrosomal protein that is essential for primary cilia formation
    Yili Yin
    Division of Cell and Developmental Biology, Wellcome Trust Biocentre, The University of Dundee, Dundee DD1 5EH, UK
    Development 136:655-64. 2009
    ..Thus, Talpid3 is one of a growing number of centrosomal proteins that affect both ciliogenesis and Hh signalling...
  14. ncbi Initiation of dorso-ventral axis during chick limb development
    Muriel Altabef
    Department of Anatomy and Developmental Biology, University College London, Medawar Building, Malet Place, UK
    Mech Dev 116:19-27. 2002
    ..Furthermore, we suggest that an inhibitor present in the flank normally prevents Lmx-1 expression in this region and restricts its expression to limb-forming regions...
  15. ncbi Negative feedback predominates over cross-regulation to control ERK MAPK activity in response to FGF signalling in embryos
    Terence Gordon Smith
    Division of Cell and Developmental Biology, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, UK
    FEBS Lett 580:4242-5. 2006
    ..We conclude that MKP-3/Pyst1 expression is mediated by ERK activation and that negative feedback control predominates in limiting the extent of FGF-induced ERK activity...
  16. ncbi Negative feedback regulation of FGF signaling levels by Pyst1/MKP3 in chick embryos
    Maxwell C Eblaghie
    Division of Cell and Developmental Biology, School of Life Sciences, University of Dundee, Dow Street, United Kingdom
    Curr Biol 13:1009-18. 2003
    ..Our results demonstrate both the importance of MAPK signaling in neural induction and limb bud outgrowth and the critical role played by dual specificity MAP kinase phosphatases in regulating developmental outcomes in vertebrates...
  17. ncbi Expression of limb initiation genes and clues to the morphological diversification of threespine stickleback
    Nicholas J Cole
    Division of Cell and Developmental Biology, Wellcome Trust Biocentre, University of Dundee, Dundee DD1 5EH, Scotland, UK
    Curr Biol 13:R951-2. 2003
  18. ncbi Fgf signaling controls the number of phalanges and tip formation in developing digits
    Juan Jose Sanz-Ezquerro
    Division of Cell and Developmental Biology, School of Life Sciences, Wellcome Trust Building Medical Sciences Institute complex, University of Dundee, Dow Street, DD1 5EH, Dundee, United Kingdom
    Curr Biol 13:1830-6. 2003
    ..We also propose that the process that generates the digit tips is independent of that which generates more proximal phalanges. This has implications for understanding human limb congenital malformations and evolution of digit diversity...
  19. ncbi Comparative analysis of 3D expression patterns of transcription factor genes and digit fate maps in the developing chick wing
    Malcolm Fisher
    Division of Cell and Developmental Biology, University of Dundee, Dundee, Scotland, United Kingdom
    PLoS ONE 6:e18661. 2011
    ..These dynamic patterns of expression suggest that these genes may play different roles in digit identity either together or in combination at different stages including the digit condensation stage...
  20. ncbi Cell fate in the chick limb bud and relationship to gene expression
    N Vargesson
    Department of Anatomy and Developmental Biology, University College London, UK
    Development 124:1909-18. 1997
    ..Instead the changes in extent of expression fit with the fate maps and can be attributed to expansion and fanning out of cell populations initially expressing the genes...
  21. ncbi Expression of the short stature homeobox gene Shox is restricted by proximal and distal signals in chick limb buds and affects the length of skeletal elements
    Eva Tiecke
    Division of Cell and Developmental Biology, School of Life Sciences, University of Dundee, Dow Street, Dundee, DD1 5EH, UK
    Dev Biol 298:585-96. 2006
    ..These results fit well with the proposed role of Shox in cartilage and bone differentiation and suggest chick embryos as a useful model to study further the role of Shox in limb development...
  22. ncbi The expression of Flrt3 during chick limb development
    Terence G Smith
    Division of Cell and Developmental Biology, University of Dundee, Dundee, UK
    Int J Dev Biol 50:701-4. 2006
    ..FLRT3 may have a crucial role in regulating cellular adhesion between the epithelial apical ridge and the underlying mesenchyme and in establishing the dorso-ventral position of the ridge...
  23. ncbi Regulation of Tbx3 expression by anteroposterior signalling in vertebrate limb development
    Stefan Tümpel
    Division of Cell and Developmental Biology, The Wellcome Trust Biocentre, University of Dundee, Dundee DD1 5EH, United Kingdom
    Dev Biol 250:251-62. 2002
    ..Anterior Tbx3 expression appears to be related to the width of limb bud, which determines digit number...
  24. ncbi Shh, Fgf4 and Hoxd gene expression in the mouse limb mutant hypodactyly
    K E Robertson
    Department of Anatomy and Developmental Biology, University College London, UK
    Int J Dev Biol 41:733-6. 1997
    ..Similar interactions between mutant and normal HOX gene products have been suggested to occur in the human semidominant disorder, synpolydactyly, caused by mutations in HOXD13...
  25. ncbi Tbx18 and boundary formation in chick somite and wing development
    Mikiko Tanaka
    Division of Cell and Developmental Biology, Wellcome Trust Biocentre, University of Dundee, Dundee DD1 5EH, UK
    Dev Biol 268:470-80. 2004
    ..These results suggest that Tbx18 is involved in producing mesodermal boundaries, generating in paraxial mesoderm morphological boundaries between somites and in lateral plate mesoderm a wing- or non-wing-forming boundary...
  26. ncbi Expression of genes encoding bone morphogenetic proteins and sonic hedgehog in talpid (ta3) limb buds: their relationships in the signalling cascade involved in limb patterning
    P H Francis-West
    Department of Anatomy and Developmental Biology, University College of London, United Kingdom
    Dev Dyn 203:187-97. 1995
    ..In addition, the dissociation between the expression of shh and Bmps suggests distinct roles for the encoded molecules in signalling and response in a-p patterning of limb buds...
  27. ncbi Tbx genes and limb identity in chick embryo development
    A Isaac
    Department of Anatomy and Developmental Biology, University College London, London WC1E 6BT, UK
    Development 125:1867-75. 1998
    ..The ectopic limb always displays a limb-like Tbx-3 expression. Thus Tbx-4 and Tbx-5 are strong candidates for encoding 'wingness' and 'legness'...
  28. ncbi Integration of growth and specification in chick wing digit-patterning
    Matthew Towers
    Division of Cell and Developmental Biology, WTB MSI Complex, University of Dundee, Dow Street, Dundee DD1 5EH, UK
    Nature 452:882-6. 2008
    ..Our findings that Shh signalling has dual functions that can be temporally uncoupled have implications for understanding congenital and evolutionary digit reductions...
  29. ncbi The expression of Fat-1 cadherin during chick limb development
    Terence G Smith
    Division of Cell and Developmental Biology, University of Dundee, Dow Street, Dundee DD1 5EH, U K
    Int J Dev Biol 51:173-6. 2007
    ..During hand plate formation, Fat-1 transcripts were expressed in the mesenchyme adjacent to the wrist joint zone and in the interdigit mesenchyme...
  30. ncbi The chicken talpid3 gene encodes a novel protein essential for Hedgehog signaling
    Megan G Davey
    Division of Cell and Developmental Biology, Wellcome Trust Biocentre WTB, University of Dundee, Dundee DD1 5EH, United Kingdom
    Genes Dev 20:1365-77. 2006
    ..These results suggest that the talpid3 protein operates in the cytoplasm to regulate the activity of both Gli repressor and activator proteins...
  31. ncbi Micro-magnetic resonance imaging and embryological analysis of wild-type and pma mutant mice with clubfoot
    Suzanne Duce
    Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, UK
    J Anat 216:108-20. 2010
    ....
  32. ncbi Characterisation of hoxa gene expression in the chick limb bud in response to FGF
    N Vargesson
    Department of Anatomy and Developmental Biology, University College London, London, United Kingdom
    Dev Dyn 220:87-90. 2001
    ..Therefore FGF4 signalling is necessary but not sufficient for Hoxa gene expression in the limb bud...
  33. ncbi Integrating technologies for comparing 3D gene expression domains in the developing chick limb
    Malcolm E Fisher
    Department of Cell and Developmental Biology, University of Dundee, Dow Street, Dundee, UK
    Dev Biol 317:13-23. 2008
    ..Such an atlas could be extended to include other types of data, such as fate maps, and the approach is also more generally applicable to embryos, organs and tissues...
  34. ncbi Fin development in a cartilaginous fish and the origin of vertebrate limbs
    Mikiko Tanaka
    Division of Cell and Developmental Biology, Wellcome Trust Biocentre, University of Dundee, Dow Street, Dundee DD1 5EH, UK
    Nature 416:527-31. 2002
    ..Freeing' fins from the body axis and establishing a separate 'limb' axis has been proposed to be a crucial step in evolution of tetrapod limbs. We suggest that Shh plays a critical role in this process...
  35. ncbi Hox9 genes and vertebrate limb specification
    M J Cohn
    Department of Anatomy and Developmental Biology, University College London Medical School, UK
    Nature 387:97-101. 1997
    ..Independent regulation of Hox gene expression in lateral plate mesoderm may have been a key step in the evolution of paired appendages...
  36. ncbi Bone morphogenetic proteins and a signalling pathway that controls patterning in the developing chick limb
    P H Francis
    Department of Anatomy and Developmental Biology, University College London Medical School, UK
    Development 120:209-18. 1994
    ..There is a close relationship, both temporal and spatial, between the activation of the Bmp-2 and Hoxd-13 genes in response to retinoic acid and polarizing region grafts, suggesting that expression of the two genes might be linked...
  37. ncbi Limbs: a model for pattern formation within the vertebrate body plan
    M J Cohn
    Department of Anatomy and Developmental Biology, University College and Middlesex School of Medicine, London, UK
    Trends Genet 12:253-7. 1996
    ..The limb is a model system and the same sets of molecules are used at different times and places in vertebrate embryos. There is also remarkable conservation of the molecular mechanisms of limb development in insects and vertebrates...
  38. ncbi Local origin of cells in FGF-4 - induced outgrowth of amputated chick wing bud stumps
    K Kostakopoulou
    Department of Anatomy and Developmental Biology, University College London, United Kingdom
    Int J Dev Biol 41:747-50. 1997
    ..We show that the FGF-4-induced outgrowth of the regenerating wing bud stump is comprised of mesenchyme cells that originate from a region within 200 microm of the FGF-4 bead, and that cells proximal to the bead move distally...
  39. ncbi FGF and genes encoding transcription factors in early limb specification
    A Isaac
    Department of Anatomy and Developmental Biology, University College London, UK
    Mech Dev 93:41-8. 2000
    ..FGF-2 leads to ectopic expression of Tbx-4 and Tbx-5 as rapidly as ectopic expression of SnR, but the patterns of ectopic transcripts suggest that induction of SnR and Tbx gene expression occur via different pathways...
  40. ncbi Autoregulation of Shh expression and Shh induction of cell death suggest a mechanism for modulating polarising activity during chick limb development
    J J Sanz-Ezquerro
    Department of Anatomy and Physiology, Wellcome Trust Biocentre, University of Dundee, Dow Street, Dundee DD1 5EH, UK
    Development 127:4811-23. 2000
    ..They also suggest that cell death induced by Shh could be the cellular mechanism involved. Such an autoregulatory process based on cell death could represent a general way for regulating patterning signals in embryos...
  41. ncbi Distribution of polarizing activity and potential for limb formation in mouse and chick embryos and possible relationships to polydactyly
    M Tanaka
    Department of Anatomy and Physiology, Wellcome Trust Biocentre, University of Dundee, Dow Street, Dundee DD1 5EH, UK
    Development 127:4011-21. 2000
    ..Furthermore, when we apply simultaneously a polarizing signal and a limb induction signal to early chick flank, this leads to limb duplications...
  42. ncbi Micro-magnetic resonance imaging study of live quail embryos during embryonic development
    Suzanne Duce
    Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, DD1 5EH Dundee, UK
    Magn Reson Imaging 29:132-9. 2011
    ....
  43. ncbi Cholesterol metabolism: the main pathway acting downstream of cytochrome P450 oxidoreductase in skeletal development of the limb
    Katy Schmidt
    Division of Cell and Developmental Biology, Wellcome Trust Biocentre, University of Dundee, Dundee DD1 5EH, United Kingdom
    Mol Cell Biol 29:2716-29. 2009
    ..Thus, cellular POR-dependent cholesterol synthesis is essential during limb and skeletal development. Modulation of P450 activity could contribute to susceptibility of the embryo and developing organs to teratogenesis...
  44. ncbi Fate maps old and new
    J D Clarke
    Department of Anatomy and Developmental Biology, University College London, UK
    Nat Cell Biol 1:E103-9. 1999
    ....
  45. ncbi "Fingering" the vertebrate limb
    J J Sanz-Ezquerro
    Division of Cell and Developmental Biology, School of Life Sciences, University of Dundee, Great Britain
    Differentiation 69:91-9. 2001
    ..Interactions between polarizing region cells and other cells in the limb bud ensure that a thumb develops at one edge of the hand (anterior) and a little finger at the other (posterior)...
  46. ncbi Analysis of talpid3 and wild-type chicken embryos reveals roles for Hedgehog signalling in development of the limb bud vasculature
    M G Davey
    Division of Cell and Developmental Biology, WTB, University of Dundee, Dundee, UK
    Dev Biol 301:155-65. 2007
    ..Thus Hedgehog signalling has a pivotal role in the cascade of angiogenic events in a growing embryonic organ which is similar to that proposed in tumours...
  47. ncbi Expression patterns of Notch1, Serrate1, Serrate2 and Delta1 in tissues of the developing chick limb
    N Vargesson
    Department of Anatomy and Developmental Biology, University College London, Medawar Building, Gower Street, London, WC1E 6BT, UK
    Mech Dev 77:197-9. 1998
    ..We show these genes are expressed, in different combinations, in the vasculature, the musculature and the tissues of the handplate...
  48. ncbi Roles for alpha 1 connexin in morphogenesis of chick embryos revealed using a novel antisense approach
    D L Becker
    Department of Anatomy and Developmental Biology, University College London, UK
    Dev Genet 24:33-42. 1999
    ..The results imply a major role for alpha 1 connexin communication in the integration of signaling required for pattern formation during embryonic development. This novel antisense technique may also be widely applicable...
  49. ncbi Dorso-ventral ectodermal compartments and origin of apical ectodermal ridge in developing chick limb
    M Altabef
    Department of Anatomy and Developmental Biology, University College London, UK
    Development 124:4547-56. 1997
    ....
  50. ncbi Micro-magnetic resonance imaging of avian embryos
    Xiaojing Li
    Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, UK
    J Anat 211:798-809. 2007
    ..The work with the living quail embryos lays the foundations for using micro-magnetic resonance imaging as an experimental tool to follow the consequences of such manipulations over time...
  51. ncbi Fate map of the developing chick face: analysis of expansion of facial primordia and establishment of the primary palate
    I M McGonnell
    Department of Anatomy and Developmental Biology, University College London, United Kingdom
    Dev Dyn 212:102-18. 1998
    ..Expansion of other cell populations in the treated upper face was more even rather than directed. This further supports the idea that tension exerted by neighbouring tissues plays a major role in global shaping of the upper face...
  52. ncbi Connexin43 gap junction protein plays an essential role in morphogenesis of the embryonic chick face
    I M McGonnell
    Department of Anatomy and Developmental Biology, University College London, London, United Kingdom
    Dev Dyn 222:420-38. 2001
    ..Taken together, these results indicate that connexin43 plays an essential role during early morphogenesis and subsequent outgrowth of the developing chick face...
  53. ncbi Molecular interactions between Tbx3 and Bmp4 and a model for dorsoventral positioning of mammary gland development
    Kyoung Won Cho
    Division in Anatomy and Developmental Biology, Department of Oral Biology, Research Center for Orofacial Hard Tissue Regeneration, Brain Korea21 Project, College of Dentistry, Yonsei Center of Biotechnology, Yonsei University, Seoul 120 752, Korea
    Proc Natl Acad Sci U S A 103:16788-93. 2006
    ..Furthermore, Bmp signaling appears to be a fundamental feature of DV patterning...
  54. ncbi Rescue of cytochrome P450 oxidoreductase (Por) mouse mutants reveals functions in vasculogenesis, brain and limb patterning linked to retinoic acid homeostasis
    Vanessa Ribes
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, UMR 7104 du CNRS, U 596 de l INSERM, Universite Louis Pasteur, BP 10142, 67404 Illkirch Cedex, CU de Strasbourg, France
    Dev Biol 303:66-81. 2007
    ....
  55. ncbi Long-range conserved non-coding SHOX sequences regulate expression in developing chicken limb and are associated with short stature phenotypes in human patients
    Nitin Sabherwal
    Department of Molecular Human Genetics, University of Heidelberg, Im Neuenheimer Feld 366, 69120 Heidelberg, Germany
    Hum Mol Genet 16:210-22. 2007
    ....
  56. ncbi Craniofacial development in the talpid3 chicken mutant
    Paul Buxton
    Department of Craniofacial Development, GKT Dental Institute, Floor 27 Guy s Tower, Guy s Hospital, London SE1 9RT, UK
    Differentiation 72:348-62. 2004
    ..This gene expression analysis in the talpid(3) head also confirms and extends knowledge of the importance of Shh signaling and the balance between activation and repression of Shh targets in many aspects of craniofacial morphogenesis...
  57. ncbi Identification of novel roles of the cytochrome p450 system in early embryogenesis: effects on vasculogenesis and retinoic Acid homeostasis
    Diana M E Otto
    Cancer Research UK, Molecular Pharmacology Unit, Biomedical Research Centre, Ninewells Hospital and Medical School, Dundee DD1 9SY, United Kingdom
    Mol Cell Biol 23:6103-16. 2003
    ....
  58. ncbi Pattern formation and developmental mechanisms: good mileage from comparative studies in cell biology, gene regulation, development and evolution
    William McGinnis
    Curr Opin Genet Dev 15:355-7. 2005
  59. ncbi A robust system for RNA interference in the chicken using a modified microRNA operon
    Raman M Das
    Department of Molecular Biology and Biotechnology, The University of Sheffield, Firth Court, Western Bank, Sheffield S10 2TN, UK
    Dev Biol 294:554-63. 2006
    ..1, Nkx2.2, Notch1 and Shh in discrete regions of the chicken embryonic nervous system. The efficiency and ease of use of this RNAi system paves the way for large-scale genetic screens in the chicken embryo...
  60. ncbi Sequence and comparative analysis of the chicken genome provide unique perspectives on vertebrate evolution
    Ladeana W Hillier
    Genome Sequencing Center, Washington University School of Medicine, Campus Box 8501, 4444 Forest Park Avenue, St Louis, Missouri 63108, USA
    Nature 432:695-716. 2004
    ..The distinctive properties of avian microchromosomes, together with the inferred patterns of conserved synteny, provide additional insights into vertebrate chromosome architecture...
  61. ncbi The chicken as a model for large-scale analysis of vertebrate gene function
    William R A Brown
    Institute of Genetics, Nottingham University, Queen's Medical Centre, Nottingham NG7 2UH, UK
    Nat Rev Genet 4:87-98. 2003
  62. ncbi A comprehensive collection of chicken cDNAs
    Paul E Boardman
    Department of Biomolecular Sciences, University of Manchester Institute of Science and Technology, P.O. Box 88, M60 1QD, Manchester, United Kingdom
    Curr Biol 12:1965-9. 2002
    ..Using this dataset, we estimate that chickens have approximately 35,000 genes in total, suggesting that this number may be a characteristic feature of vertebrates...
  63. ncbi The progress zone -- alive or dead?
    Cheryll Tickle
    Nat Cell Biol 4:E216-7. 2002