Claire Thorne

Summary

Affiliation: University College London
Country: UK

Publications

  1. ncbi request reprint Higher rates of post-partum complications in HIV-infected than in uninfected women irrespective of mode of delivery
    Simona Fiore
    Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
    AIDS 18:933-8. 2004
  2. ncbi request reprint Are girls more at risk of intrauterine-acquired HIV infection than boys?
    Claire Thorne
    Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, University College, London, UK
    AIDS 18:344-7. 2004
  3. doi request reprint Policies and practices for the clinical management of HIV/HCV coinfected children in Europe: an epidemiological survey
    Kirsty England
    MRC Centre of Epidemiology for Child Health, Institute of Child Health, University College London, London, UK
    Eur J Pediatr 168:915-7. 2009
  4. pmc Factors associated with abandonment of infants born to HIV-positive women: results from a Ukrainian birth cohort
    Heather Bailey
    MRC Centre of Epidemiology for Child Health, UCL Institute of Child Health, University College London, UK
    AIDS Care 22:1439-48. 2010
  5. ncbi request reprint Treatment options for the prevention of mother-to-child transmission of HIV
    Claire Thorne
    Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, University College London, London, UK
    Curr Opin Investig Drugs 6:804-11. 2005
  6. ncbi request reprint Managing mother-to-child transmission of HIV infection in developed-country settings
    Claire Thorne
    Institute of Child Health, Centre for Paediatric Epidemiology and Biostatistics, 30 Guilford Street, London, WC1N 1EH, UK
    Womens Health (Lond Engl) 1:385-99. 2005
  7. pmc Prevention of mother-to-child transmission of human immunodeficiency virus among pregnant women using injecting drugs in Ukraine, 2000-10
    Claire Thorne
    MRC Centre of Epidemiology for Child Health, UCL Institute of Child Health, University College London, London, UK
    Addiction 107:118-28. 2012
  8. ncbi request reprint The safety of antiretroviral drugs in pregnancy
    Claire Thorne
    University College London, Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, 30 Guilford Street, London, WC1N 1EH, UK
    Expert Opin Drug Saf 4:323-35. 2005
  9. ncbi request reprint Prevention of mother-to-child transmission of HIV infection
    Claire Thorne
    Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, University College London, London, UK
    Curr Opin Infect Dis 17:247-52. 2004
  10. pmc Progress in prevention of mother-to-child transmission of HIV infection in Ukraine: results from a birth cohort study
    Claire Thorne
    MRC Centre of Epidemiology for Child Health, UCL Institute of Child Health, University College London, UK
    BMC Infect Dis 9:40. 2009

Detail Information

Publications57

  1. ncbi request reprint Higher rates of post-partum complications in HIV-infected than in uninfected women irrespective of mode of delivery
    Simona Fiore
    Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
    AIDS 18:933-8. 2004
    ..To inform the debate on the use of elective caesarean section (CS) delivery in HIV-infected women, we investigated the occurrence of clinical events in the immediate post-partum period in women delivering in 13 European centres...
  2. ncbi request reprint Are girls more at risk of intrauterine-acquired HIV infection than boys?
    Claire Thorne
    Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, University College, London, UK
    AIDS 18:344-7. 2004
    ..Girls were at a 1.5 times increased risk of MTCT overall, but the sex effect was limited to elective caesarean section deliveries, suggesting that girls may have an increased risk of intrauterine transmission compared with boys...
  3. doi request reprint Policies and practices for the clinical management of HIV/HCV coinfected children in Europe: an epidemiological survey
    Kirsty England
    MRC Centre of Epidemiology for Child Health, Institute of Child Health, University College London, London, UK
    Eur J Pediatr 168:915-7. 2009
    ..Limited experience in the clinical management of this group and the lack of an evidence base to guide policy may be a barrier to achieving optimal care and treatment...
  4. pmc Factors associated with abandonment of infants born to HIV-positive women: results from a Ukrainian birth cohort
    Heather Bailey
    MRC Centre of Epidemiology for Child Health, UCL Institute of Child Health, University College London, UK
    AIDS Care 22:1439-48. 2010
    ..23 for ≥19 years versus ≤16 years). Interventions to extend family planning and IDU harm reduction services along with non-stigmatising antenatal care to marginalised women are needed, and may reduce abandonment...
  5. ncbi request reprint Treatment options for the prevention of mother-to-child transmission of HIV
    Claire Thorne
    Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, University College London, London, UK
    Curr Opin Investig Drugs 6:804-11. 2005
    ....
  6. ncbi request reprint Managing mother-to-child transmission of HIV infection in developed-country settings
    Claire Thorne
    Institute of Child Health, Centre for Paediatric Epidemiology and Biostatistics, 30 Guilford Street, London, WC1N 1EH, UK
    Womens Health (Lond Engl) 1:385-99. 2005
    ....
  7. pmc Prevention of mother-to-child transmission of human immunodeficiency virus among pregnant women using injecting drugs in Ukraine, 2000-10
    Claire Thorne
    MRC Centre of Epidemiology for Child Health, UCL Institute of Child Health, University College London, London, UK
    Addiction 107:118-28. 2012
    ..To compare clinical status, mother-to-child transmission (MTCT) rates, use of prevention of (PMTCT) interventions and pregnancy outcomes between HIV-infected injecting drug users (IDUs) and non-IDUs...
  8. ncbi request reprint The safety of antiretroviral drugs in pregnancy
    Claire Thorne
    University College London, Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, 30 Guilford Street, London, WC1N 1EH, UK
    Expert Opin Drug Saf 4:323-35. 2005
    ..Based on current knowledge, the immense benefits of antiretroviral prophylaxis in reducing the risk of MTCT, far outweigh the potential for adverse effects...
  9. ncbi request reprint Prevention of mother-to-child transmission of HIV infection
    Claire Thorne
    Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, University College London, London, UK
    Curr Opin Infect Dis 17:247-52. 2004
    ..There is a need for alternative, easier and more effective interventions for population-based programmes...
  10. pmc Progress in prevention of mother-to-child transmission of HIV infection in Ukraine: results from a birth cohort study
    Claire Thorne
    MRC Centre of Epidemiology for Child Health, UCL Institute of Child Health, University College London, UK
    BMC Infect Dis 9:40. 2009
    ....
  11. doi request reprint Central Asia: hotspot in the worldwide HIV epidemic
    Claire Thorne
    MRC Centre of Epidemiology for Child Health, UCL Institute of Child Health, University College London, 30 Guilford Street, London, UK
    Lancet Infect Dis 10:479-88. 2010
    ..Some recent progress has been made towards scaling-up prevention, treatment, and care services, including harm reduction for IDUs, although key challenges remain...
  12. ncbi request reprint Injecting drug use in pregnant HIV-infected women in Europe
    Claire Thorne
    Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, University College London, 30 Guilford Street, London, WC1N 1EH, UK
    Med Wieku Rozwoj 10:1005-16. 2006
    ..to describe the characteristics of pregnant HIV-infected women with past or current injecting drug use (IDU) and their infants in a large European cohort...
  13. ncbi request reprint Antenatal and neonatal antiretroviral therapy in HIV-infected women and their infants: a review of safety issues
    Claire Thorne
    Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, University College, 30 Guilford Street, WC1N 1EH London, UK
    Med Wieku Rozwoj 7:425-36. 2003
    ....
  14. ncbi request reprint Safety of agents used to prevent mother-to-child transmission of HIV: is there any cause for concern?
    Claire Thorne
    Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, University College London, London, UK
    Drug Saf 30:203-13. 2007
    ..However, these potential adverse effects require further and longer term monitoring because they are likely to be rare and to occur later in childhood...
  15. ncbi request reprint Mother-to-child transmission of HIV infection and its prevention
    Claire Thorne
    Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, University College London, UK
    Curr HIV Res 1:447-62. 2003
    ..However, the key to prevention of paediatric HIV infections is adequate prevention of infection in women of reproductive age...
  16. pmc Predictors of pregnancy and changes in pregnancy incidence among HIV-positive women accessing HIV clinical care
    Susie E Huntington
    Medical Research Council MRC Centre of Epidemiology for Child Health, Institute of Child Health, University College London, London, UK
    AIDS 27:95-103. 2013
    ..To describe predictors of pregnancy and changes in pregnancy incidence among HIV-positive women accessing HIV clinical care...
  17. pmc Characteristics and management of HIV-1-infected pregnant women enrolled in a randomised trial: differences between Europe and the USA
    Marie Louise Newell
    Centre of Paediatric Epidemiology and Biostatistics, Institute of Child Health, University College London, UK
    BMC Infect Dis 7:60. 2007
    ....
  18. pmc Impact of expanded access to combination antiretroviral therapy in pregnancy: results from a cohort study in Ukraine
    Heather Bailey
    Medical Research Council Centre of Epidemiology for Child Health, University College London Institute of Child Health, 30 Guilford Street, London, WC1N 1EH, England
    Bull World Health Organ 91:491-500. 2013
    ..To investigate the scale-up of antenatal combination antiretroviral therapy (cART) in Ukraine since this became part of the national policy for the prevention of mother-to-child transmission (PMTCT) of human immunodeficiency virus (HIV)...
  19. ncbi request reprint Antiretroviral therapy and mother-to-child transmission of HIV-1
    Marie Louise Newell
    University College London, Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
    Expert Rev Anti Infect Ther 2:717-32. 2004
    ..However, postnatal transmission of infection through breastfeeding significantly reduces the longer-term efficacy of these strategies. Ongoing research is focusing on the use of antiretroviral therapy in the breastfeeding period...
  20. pmc Treatment and disease progression in a birth cohort of vertically HIV-1 infected children in Ukraine
    Saboura Mahdavi
    MRC Centre of Epidemiology for Child Health, UCL Institute of Child Health, University College London, London, UK
    BMC Pediatr 10:85. 2010
    ..Our objective was to describe the clinical, immunological and virological characteristics, treatment and response in vertically HIV-infected children living in Ukraine and followed from birth...
  21. ncbi request reprint Within and between race differences in lymphocyte, CD4+, CD8+ and neutrophil levels in HIV-uninfected children with or without HIV exposure in Europe and Uganda
    Madeleine Bunders
    Centre for Paediatric Epidemiology, Institute of Child Health, University College, London, UK
    Ann Trop Paediatr 26:169-79. 2006
    ..Racial immuno-haematological differences have been reported in children but to date have not been well quantified...
  22. ncbi request reprint HIV and HCV progression in parenterally coinfected children
    Kirsty England
    MRC Centre of Epidemiology for Child Health, UCL Institute of Child Health, University College London, London, UK
    Curr HIV Res 7:346-53. 2009
    ....
  23. ncbi request reprint CD4 cell response to antiretroviral therapy in children with vertically acquired HIV infection: is it associated with age at initiation?
    Marie Louise Newell
    Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, University College London, United Kingdom
    J Infect Dis 193:954-62. 2006
    ..Considerable uncertainty remains as to whether early initiation of antiretroviral therapy (ART) in children with vertically acquired human immunodeficiency virus (HIV) infection increases the benefit in terms of immunological response...
  24. ncbi request reprint Does exposure to antiretroviral therapy affect growth in the first 18 months of life in uninfected children born to HIV-infected women?
    Claire Hankin
    Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, 30 Guilford Street, London, WC1N 1EH, United Kingdom
    J Acquir Immune Defic Syndr 40:364-70. 2005
    ..10 [P = 0.019]; height, -0.12 [P = 0.008]; and OFC, -0.14 [P = 0.001]). Although the effect of combination therapy exposure is minimal, long-term monitoring of these children is important...
  25. ncbi request reprint European participation in an international perinatal trial
    Simona Fiore
    Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, University College, 30 Guilford Street, WC1N 1EH London, UK
    Med Wieku Rozwoj 7:449-58. 2003
    ..To compare the population enrolled in a Phase III trial to that enrolled during the same period in a parallel longitudinal cohort, and to assess the generalisability of the trial results...
  26. ncbi request reprint Disease progression in children with vertically-acquired HIV infection in sub-Saharan Africa: reviewing the need for HIV treatment
    Kirsty Little
    Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, University College London, UK
    Curr HIV Res 5:139-53. 2007
    ..Additionally, improvements in health infrastructures could improve care provision, not only through improved detection and monitoring but also through treatment of co-morbidities and nutritional support...
  27. doi request reprint Influence of short-course antenatal antiretroviral therapy on viral load and mother-to-child transmission in subsequent pregnancies among HIV-infected women
    Clare E French
    MRC Centre of Epidemiology for Child Health, UCL Institute of Child Health, London, UK
    Antivir Ther 18:183-92. 2013
    ..HIV-infected women not requiring treatment for their own health usually receive short-course antiretroviral therapy (ART) during pregnancy. Little is known about the effect of this on response to HAART in subsequent pregnancies...
  28. ncbi request reprint Increased risk of adverse pregnancy outcomes in HIV-infected women treated with highly active antiretroviral therapy in Europe
    Claire Thorne
    Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, University College London, London, UK
    AIDS 18:2337-9. 2004
    ..05, 95% CI 1.43, 2.95), particularly severe prematurity. The implication of increased prematurity is evidenced in high neonatal mortality in these groups (0.66% for infants at 34-36 weeks and 7.37% at < 34 weeks' gestation)...
  29. ncbi request reprint Maternal and infant factors and lymphocyte, CD4 and CD8 cell counts in uninfected children of HIV-1-infected mothers
    Madeleine Bunders
    Institue of Child Health, University College, London, UK
    AIDS 19:1071-9. 2005
    ..To evaluate the effects of antiretroviral treatment (ART) for mother-to-child transmission of HIV and infant/maternal characteristics on total lymphocytes (TLC) and lymphocyte subsets in uninfected children of HIV-1-infected mothers...
  30. ncbi request reprint Antiretroviral therapy-associated modulation of Th1 and Th2 immune responses in HIV-infected pregnant women
    Simona Fiore
    Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, University College London UCL, London, UK
    J Reprod Immunol 70:143-50. 2006
    ..0-1.17; p=0.005). HAART use in pregnancy provides significant benefits in delaying HIV disease progression and reducing the risk of mother-to-child-transmission, but may be counterproductive in terms of successful pregnancy outcome...
  31. pmc Using two on-going HIV studies to obtain clinical data from before, during and after pregnancy for HIV-positive women
    Susie E Huntington
    Research Department of Infection and Population Health, University College London, Royal Free Campus, Rowland Hill Street, London, NW3 2PF, UK
    BMC Med Res Methodol 12:110. 2012
    ..A methodology was developed to find and match records for women reported to both studies thereby obtaining clinical and treatment data on pregnant HIV-positive women not available from either dataset alone...
  32. pmc Cervical screening within HIV care: findings from an HIV-positive cohort in Ukraine
    Heather Bailey
    MRC Centre of Epidemiology for Child Health, UCL Institute of Child Health, University College London, London, United Kingdom
    PLoS ONE 7:e34706. 2012
    ..Little is known about cervical screening coverage or the prevalence of abnormal cytology among HIV-positive women in Ukraine, which has the most severe HIV epidemic in Europe...
  33. pmc Body fat abnormality in HIV-infected children and adolescents living in Europe: prevalence and risk factors
    Naufil Alam
    MRC Centre of Epidemiology for Child Health, University College London Institute of Child Health, London, UK
    J Acquir Immune Defic Syndr 59:314-24. 2012
    ..To estimate the prevalence of and identify risk factors for lipodystrophy syndrome (LS) and body fat abnormality in a population of HIV-infected children and adolescents...
  34. ncbi request reprint Older children and adolescents surviving with vertically acquired HIV infection
    Claire Thorne
    Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, London, UK
    J Acquir Immune Defic Syndr 29:396-401. 2002
    ..As they enter adolescence, additional services are needed including support with disclosure to others, therapy, and sexual health...
  35. doi request reprint Response to antiretroviral therapy (ART): comparing women with previous use of zidovudine monotherapy (ZDVm) in pregnancy with ART naïve women
    Susie Huntington
    Centre for Paediatric Epidemiology and Biostatistics, UCL Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
    BMC Infect Dis 14:127. 2014
    ..Short-term zidovudine monotherapy (ZDVm) remains an option for some pregnant HIV-positive women not requiring treatment for their own health but may affect treatment responses once antiretroviral therapy (ART) is subsequently started...
  36. doi request reprint Improvements in virological control among women conceiving on combination antiretroviral therapy in Western Europe
    Heather Bailey
    University College London, London, UK
    AIDS 27:2312-5. 2013
    ..In adjusted analyses, younger women and those with at least two children were at increased risk of virological failure, highlighting the importance of close monitoring and adherence support. ..
  37. doi request reprint Earlier initiation of ART and further decline in mother-to-child HIV transmission rates, 2000-2011
    Claire L Townsend
    aCentre for Paediatric Epidemiology and Biostatistics, UCL Institute of Child Health, University College London bGuys and St Thomas NHS Foundation Trust cImperial College Healthcare NHS Trust, London, UK
    AIDS 28:1049-57. 2014
    ..To analyze mother-to-child HIV transmission (MTCT) rates over time in light of changes in management, demographic, and pregnancy characteristics...
  38. ncbi request reprint HIV
    Claire Thorne
    Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, UK
    Semin Fetal Neonatal Med 12:174-81. 2007
    ..However, based on current knowledge, the immense benefits of antiretroviral prophylaxis in reducing MTCT risk far outweigh the potential for adverse effects...
  39. pmc Incidence, patterns, and predictors of repeat pregnancies among HIV-infected women in the United Kingdom and Ireland, 1990-2009
    Clare E French
    MRC Centre of Epidemiology for Child Health, UCL Institute of Child Health, London, UK
    J Acquir Immune Defic Syndr 59:287-93. 2012
    ....
  40. doi request reprint Age- and sex-related reference ranges of alanine aminotransferase levels in children: European paediatric HCV network
    Kirsty England
    MRC Centre of Epidemiology for Child Health, Institute of Child Health, University College London, London, UK
    J Pediatr Gastroenterol Nutr 49:71-7. 2009
    ..Recently, ALT reference ranges for adults were queried and revised ranges proposed with lower upper limits of normality. The appropriateness of current paediatric ALT reference ranges is unclear...
  41. pmc Insufficient antiretroviral therapy in pregnancy: missed opportunities for prevention of mother-to-child transmission of HIV in Europe
    Heather Bailey
    MRC Centre of Epidemiology for Child Health, UCL Institute of Child Health, University College London, London, UK
    Antivir Ther 16:895-903. 2011
    ..Duration of antenatal combination antiretroviral therapy (ART) is strongly associated with MTCT risk...
  42. ncbi request reprint Vertically acquired paediatric coinfection with HIV and hepatitis C virus
    Kirsty England
    Centre for Paediatric Epidemiology and Biostatistics, Institute of Child Health, University College London, London, UK
    Lancet Infect Dis 6:83-90. 2006
    ..Future research must therefore focus on vertically acquired HIV/HCV coinfection to inform treatment trials addressing coinfection management...
  43. ncbi request reprint Antiretroviral therapy during pregnancy and the risk of an adverse outcome
    Claire Thorne
    N Engl J Med 348:471-2; author reply 471-2. 2003
  44. ncbi request reprint Pregnancy and HIV infection: A european consensus on management
    Oriol Coll
    Hospital Clinic, University of Barcelona, Spain
    AIDS 16:S1-18. 2002
  45. ncbi request reprint Increasing likelihood of further live births in HIV-infected women in recent years
    Annalisa Agangi
    Department of Gynaecology and Obstetrics, University Federico II, Naples, Italy
    BJOG 112:881-8. 2005
    ..To examine how the subsequent childbearing of HIV-infected mothers enrolled in the European Collaborative Study (ECS) has changed over time and identify factors predictive of further childbearing...
  46. ncbi request reprint Does highly active antiretroviral therapy increase the risk of congenital abnormalities in HIV-infected women?
    Deven Patel
    J Acquir Immune Defic Syndr 40:116-8. 2005
  47. ncbi request reprint Prevalence of sexually transmitted infections in HIV-1 infected pregnant women in Europe
    Megan Landes
    Department of Family and Community Medicine, University of Toronto, Toronto, Canada
    Eur J Epidemiol 22:925-36. 2007
    ..HIV-infected women should receive adequate screening for STIs during pregnancy together with appropriate counseling and follow-up for treatment and prevention...
  48. ncbi request reprint Pregnancies in young women with vertically acquired HIV infection in Europe
    Claire Thorne
    AIDS 21:2552-6. 2007
  49. doi request reprint Current guidelines on management of HIV-infected pregnant women: impact on mode of delivery
    Anna Suy
    Institut Clinic de Ginecologia, Obstetricia i Neonatologia, Hospital Clinic, IDIBAPS, Barcelona, Spain
    Eur J Obstet Gynecol Reprod Biol 139:127-32. 2008
    ..To evaluate acceptance, feasibility and difficulties in the application of a policy of vaginal delivery in selected cases in HIV-infected women...
  50. doi request reprint Reproductive experience of HIV-infected women living in Europe
    Simona Fiore
    Department of Obstetrics and Gynaecology, DSC Sacco, University of Milan, Milan, Italy
    Hum Reprod 23:2140-4. 2008
    ..The aim of this study was to describe the experience of pregnant and non-pregnant HIV-infected women regarding fertility and childbearing, with a view to inform policies and practices to improve reproductive outcome...
  51. doi request reprint Response to combination antiretroviral therapy: variation by age
    Caroline A Sabin
    AIDS 22:1463-73. 2008
    ..To provide information on responses to combination antiretroviral therapy in children, adolescents and older HIV-infected persons...
  52. ncbi request reprint Time to undetectable viral load after highly active antiretroviral therapy initiation among HIV-infected pregnant women
    Deven Patel
    Clin Infect Dis 44:1647-56. 2007
    ....
  53. ncbi request reprint Prevention of mother-to-child transmission of HIV infection: Ukraine experience to date
    Ruslan Malyuta
    World Health Organization Regional Office for Europe, Copenhagen, Denmark
    Eur J Public Health 16:123-7. 2006
    ..This article sets out to describe the first 2 years of the implementation of the national PMTCT programme in Ukraine...
  54. ncbi request reprint Prenatal diagnosis in human immunodeficiency virus-infected women: a new screening program for chromosomal anomalies
    Oriol Coll
    Institut Clinic de Ginecologia, Obstetricia i Neonatologia, Barcelona, Spain
    Am J Obstet Gynecol 194:192-8. 2006
    ..This study was undertaken to describe a new prenatal diagnosis program among human immunodeficiency virus (HIV)-infected women, and the perinatal outcome of this program's application over a more than 2-year period...
  55. ncbi request reprint Response to Kourtis et al. 'Use of antiretroviral therapy in pregnant HIV-infected women and the risk of premature delivery: a meta-analysis'
    Deven Patel
    AIDS 21:1656-7; author reply1657-8. 2007
  56. pmc Mother-to-child transmission risk is increased among HIV-infected pregnant women in Ukraine with serological test results positive for syphilis
    Claire Thorne
    Clin Infect Dis 47:1114-5. 2008