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| P J ThornalleySummaryAffiliation: University of Essex Country: UK Publications
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Publications
Isothiocyanates: mechanism of cancer chemopreventive actionPaul J Thornalley
Department of Biological Sciences, University of Essex, Colchester CO4 3SQ, Essex, UK
Anticancer Drugs 13:331-8. 2002..These features of isothiocyanate metabolism and chemoprevention deserve further investigation...
Quantitative screening of advanced glycation endproducts in cellular and extracellular proteins by tandem mass spectrometryPaul J Thornalley
Department of Biological Sciences, University of Essex, Central Campus, Wivenhoe Park, Colchester CO4 3SQ, Essex, UK
Biochem J 375:581-92. 2003..Increased levels of these advanced glycation endproducts were associated with vascular complications in diabetes and uraemia...- Use of aminoguanidine (Pimagedine) to prevent the formation of advanced glycation endproductsPaul J Thornalley
Department of Biological Sciences, University of Essex, Central Campus, Wivenhoe Park, Colchester, CO4 3SQ, Essex, UK
Arch Biochem Biophys 419:31-40. 2003..Pharmacological scavenging of alpha-oxoaldehydes or stimulation of host alpha-oxoaldehyde detoxification remains a worthy therapeutic strategy to prevent diabetic complications and other AGE-related disorders... - The enzymatic defence against glycation in health, disease and therapeutics: a symposium to examine the conceptP J Thornalley
Department of Biological Sciences, University of Essex, Central Campus, Wivenhoe Park, Colchester, Essex CO4 3SQ, U K
Biochem Soc Trans 31:1341-2. 2003..Improved understanding of the balance between glycation and the enzymatic anti-glycation defence will advance disease diagnosis and therapy... - Glyoxalase I--structure, function and a critical role in the enzymatic defence against glycationP J Thornalley
Department of Biological Sciences, University of Essex, Central Campus, Wivenhoe Park, Colchester, Essex CO4 3SQ, U K
Biochem Soc Trans 31:1343-8. 2003..Glyoxalase I has a critical role in the prevention of glycation reactions mediated by methylglyoxal, glyoxal and other alpha-oxoaldehydes in vivo... - Protecting the genome: defence against nucleotide glycation and emerging role of glyoxalase I overexpression in multidrug resistance in cancer chemotherapyP J Thornalley
Department of Biological Sciences, University of Essex, Central Campus, Wivenhoe Park, Colchester, Essex CO4 3SQ, U K
Biochem Soc Trans 31:1372-7. 2003..It countered drug resistance and was a potent antitumour agent against lung and prostate carcinoma. Glyoxalase I overexpression was also found in invasive ovarian cancer and breast cancer... - Advanced glycation end products in renal failurePaul J Thornalley
Department of Biological Sciences, University of Essex, Wivenhoe Park, Colchester, Essex, UK
J Ren Nutr 16:178-84. 2006..Their accumulation may impair vascular cell function and contribute to morbidity and mortality in renal disease... - Unease on the role of glyoxalase 1 in high-anxiety-related behaviourPaul J Thornalley
Disease Mechanisms and Therapeutics Research Group, Department of Biological Sciences, University of Essex, Wivenhoe Park, Colchester, Essex CO4 3Q4, UK
Trends Mol Med 12:195-9. 2006.... - Measurement of protein glycation, glycated peptides, and glycation free adductsPaul J Thornalley
Disease Mechanisms and Therapeutics Research Group, Department of Biological Sciences, University of Essex, Wivenhoe Park, Colchester, Essex, United Kingdom
Perit Dial Int 25:522-33. 2005..Glycation free adducts are the major form of glycation adduct eliminated in dialysate. LC-MS/MS may now be used to quantify concentrations, extents of protein modification, clearances, and excretion rates of glycation adducts in uremia... - Peptide mapping of human serum albumin modified minimally by methylglyoxal in vitro and in vivoNaila Ahmed
Department of Biological Sciences, University of Essex, Wivenhoe Park, Colchester, Essex CO4 3SQ, UK
Ann N Y Acad Sci 1043:260-6. 2005..Modification of arginine residues by methylglyoxal may be particularly damaging because arginine residues have a high frequency of occurrence in ligand and substrate recognition sites in receptor and enzyme active sites... - Dicarbonyl intermediates in the maillard reactionPaul J Thornalley
Department of Biological Sciences, University of Essex, Wivenhoe Park, Colchester, Essex CO4 3SQ, UK
Ann N Y Acad Sci 1043:111-7. 2005..Along with fructosamine formation, alpha-oxoaldehyde intermediates of the Maillard reaction represent a major source of damage to the proteome and genome... - The potential role of thiamine (vitamin B1) in diabetic complicationsPaul J Thornalley
Department of Biological Sciences, University of Essex, Central Campus, Wivenhoe Park, Colchester, Essex CO4 3SQ, United Kingdom
Curr Diabetes Rev 1:287-98. 2005.... - Mass spectrometric monitoring of albumin in uremiaP J Thornalley
Department of Biological Sciences, University of Essex, Essex, England, United Kingdom Kingdom
Kidney Int 58:2228-34. 2000..AGE-modified peptides are thought to bind and modify plasma proteins. Monitoring of the consequent increase in molecular mass of serum albumin may be used in surveillance of the clinical management of uremia... - Glutathione-dependent detoxification of alpha-oxoaldehydes by the glyoxalase system: involvement in disease mechanisms and antiproliferative activity of glyoxalase I inhibitorsP J Thornalley
Department of Biological and Chemical Sciences, University of Essex, Colchester, UK
Chem Biol Interact 111:137-51. 1998..The modification of DNA induces mutagenesis and apoptosis. The modification of proteins leads to protein degradation and activation of a cytokine-mediated immune response... - Suppression of the accumulation of triosephosphates and increased formation of methylglyoxal in human red blood cells during hyperglycaemia by thiamine in vitroP J Thornalley
Department of Biological Sciences, University of Essex, Central Campus, Wivenhoe Park, Colchester CO4 3SQ, Essex, UK
J Biochem 129:543-9. 2001..Biochemical changes implicated in the development of diabetic complications were thereby prevented. This provides a biochemical basis for high dose thiamine therapy for the prevention of diabetic complications... - Formation of glyoxal, methylglyoxal and 3-deoxyglucosone in the glycation of proteins by glucoseP J Thornalley
Department of Biological Sciences, University of Essex, Central Campus, Wivenhoe Park, Colchester CO43SQ, Essex, U K
Biochem J 344:109-16. 1999..Short periods of hyperglycaemia, as occur in impaired glucose tolerance, may be sufficient to increase the concentrations of alpha-oxoaldehydes in vivo... - Kinetics and mechanism of the reaction of aminoguanidine with the alpha-oxoaldehydes glyoxal, methylglyoxal, and 3-deoxyglucosone under physiological conditionsP J Thornalley
Department of Biological Sciences, University of Essex, Central Campus, Wivenhoe Park, Colchester, United Kingdom
Biochem Pharmacol 60:55-65. 2000..This effect is limited, however, by the rapid renal elimination of AG. Decreased AGE formation is implicated in the prevention of microvascular complications of diabetes by AG... 
Increased protein damage in renal glomeruli, retina, nerve, plasma and urine and its prevention by thiamine and benfotiamine therapy in a rat model of diabetesN Karachalias
Department of Biological Sciences, University of Essex, Central Campus, Wivenhoe Park, Colchester, Essex, UK
Diabetologia 53:1506-16. 2010..The aim of this study was to quantify protein damage by glycation, oxidation and nitration in a rat model of diabetes at the sites of development of microvascular complications, including the effects of thiamine and benfotiamine therapy...- High prevalence of low plasma thiamine concentration in diabetes linked to a marker of vascular diseaseP J Thornalley
Department of Biological Sciences, University of Essex, Colchester, Essex, UK
Diabetologia 50:2164-70. 2007..To assess thiamine status by analysis of plasma, erythrocytes and urine in type 1 and type 2 diabetic patients and links to markers of vascular dysfunction... - Advanced glycation endproducts: what is their relevance to diabetic complications?N Ahmed
Department of Biological Sciences, University of Essex, Central Campus, Wivenhoe Park, Colchester, Essex, CO4 3SQ, UK
Diabetes Obes Metab 9:233-45. 2007..Increasing expression of enzymes of the enzymatic defence against glycation provides a novel and potentially effective future therapeutic strategy to suppress protein glycation... - Trioses and related substances: tools for the study of pancreatic beta-cell functionL Best
Department of Medicine, University of Manchester, England, UK
Biochem Pharmacol 57:583-8. 1999..These substances are also likely to be of pathophysiological importance, especially in the context of sugar toxicity and autoxidative cell damage... - Removal of advanced glycation end products in clinical renal failure by peritoneal dialysis and haemodialysisS Agalou
Department of Biological Sciences, University of Essex, Central Campus, Wivenhoe Park, Colchester, Essex CO4 3SQ, U.K
Biochem Soc Trans 31:1394-6. 2003..Inadequate clearance of free AGEs may be linked to the increased risk of cardiovascular disease in patients with renal failure... - Degradation products of proteins damaged by glycation, oxidation and nitration in clinical type 1 diabetesN Ahmed
Department of Biological Sciences, University of Essex, Colchester, Essex CO4 3SQ, UK
Diabetologia 48:1590-603. 2005.... - The glyoxalase system: new developments towards functional characterization of a metabolic pathway fundamental to biological lifeP J Thornalley
Department of Chemistry and Biological Chemistry, University of Essex, Colchester, U.K
Biochem J 269:1-11. 1990 - Accumulation of fructosyl-lysine and advanced glycation end products in the kidney, retina and peripheral nerve of streptozotocin-induced diabetic ratsN Karachalias
Department of Biological Sciences, University of Essex, Central Campus, Wivenhoe Park, Colchester, Essex CO4 3SQ, U.K
Biochem Soc Trans 31:1423-5. 2003..High-dose therapy with thiamine and Benfotiamine suppressed the accumulation of AGEs, and is a novel approach to preventing the development of diabetic complications... - High-dose thiamine therapy counters dyslipidaemia in streptozotocin-induced diabetic ratsR Babaei-Jadidi
Department of Biological Sciences, University of Essex, Wivenhoe Park, Colchester, Essex, CO4 3SQ, UK
Diabetologia 47:2235-46. 2004..Benfotiamine was ineffective... - Signal transduction activated by the cancer chemopreventive isothiocyanates: cleavage of BID protein, tyrosine phosphorylation and activation of JNKK Xu
Department of Biological Sciences, University of Essex, Central Campus, Wivenhoe Park, Colchester, Essex, CO4 3SQ, UK
Br J Cancer 84:670-3. 2001..This suggests that in isothiocyanate-induced apoptosis, the caspase pathway has an essential role, the JNK pathway a supporting role, and inhibition of protein tyrosine phosphatases is not involved... - Quantitative screening of protein biomarkers of early glycation, advanced glycation, oxidation and nitrosation in cellular and extracellular proteins by tandem mass spectrometry multiple reaction monitoringN Ahmed
Department of Biological Sciences, University of Essex, Central Campus, Wivenhoe Park, Colchester, Essex CO4 3SQ, U.K
Biochem Soc Trans 31:1417-22. 2003..The enzymatic defences against glycation, antioxidants and proteasomal protein degradation inside cells are probable factors regulating biomarker levels of cellular protein... - Cell activation by glycated proteins. AGE receptors, receptor recognition factors and functional classification of AGEsP J Thornalley
Department of Biological Sciences, University of Essex, Colchester, UK
Cell Mol Biol (Noisy-le-grand) 44:1013-23. 1998.... - Protein and nucleotide damage by glyoxal and methylglyoxal in physiological systems--role in ageing and diseasePaul J Thornalley
Protein Damage and Systems Biology Research Group, Clinical Sciences Research Institute, Warwick Medical School, University of Warwick, University Hospital, Coventry, UK
Drug Metabol Drug Interact 23:125-50. 2008..Latest research suggests there are functional modifications of this process--implying a role in cell signalling, ageing and disease... - Increased protein glycation in cirrhosis and therapeutic strategies to prevent itNaila Ahmed
Department of Biological Sciences, University of Essex, Wivenhoe Park, Colchester, Essex CO4 3SQ, UK
Ann N Y Acad Sci 1043:718-24. 2005..Therapeutic strategies to decrease dicarbonyl compounds may be beneficial, such as dicarbonyl scavengers, glutathione repleting agents, and high-dose thiamine therapy... - High-dose thiamine therapy counters dyslipidemia and advanced glycation of plasma protein in streptozotocin-induced diabetic ratsNikolaos Karachalias
Department of Biological Sciences, University of Essex, Wivenhoe Park, Colchester, Essex CO4 3SQ, UK
Ann N Y Acad Sci 1043:777-83. 2005..These are probably lipid-derived aldehydes... - High glucose increases angiopoietin-2 transcription in microvascular endothelial cells through methylglyoxal modification of mSin3ADachun Yao
Juvenile Diabetes Research Foundation International Center for Diabetic Complications Research, Albert Einstein College of Medicine, Bronx, New York 10461, USA
J Biol Chem 282:31038-45. 2007..This novel mechanism for regulating gene expression may play a role in the pathobiology of diabetic vascular disease... - Endogenous alpha-oxoaldehydes and formation of protein and nucleotide advanced glycation endproducts in tissue damagePaul J Thornalley
Protein Damage and Systems Biology Research Group, Warwick Medical School and Systems Biology Centre, Clinical Sciences Research Institute, University of Warwick, University Hospital, Coventry CV2 2DX, UK
Novartis Found Symp 285:229-43; discussion 243-6. 2007..Tissue damage by alpha-oxoaldehyde glycation is implicated in diabetic and non-diabetic vascular disease, renal failure, cirrhosis, Alzheimer's disease, arthritis and ageing... - Effect of storage, processing and cooking on glucosinolate content of Brassica vegetablesLijiang Song
Disease Mechanisms and Therapeutic Research Group, Department of Biological Sciences, University of Essex, Wivenhoe Park, Colchester, Essex CO4 3SQ, United Kingdom
Food Chem Toxicol 45:216-24. 2007..Most of the loss of the glucosinolates (approximately 90%) was detected in the cooking water. Increased bioavailability of dietary isothiocyanates may be achieved by avoiding boiling of vegetables... - Preparation of nucleotide advanced glycation endproducts--imidazopurinone adducts formed by glycation of deoxyguanosine with glyoxal and methylglyoxalThomas Fleming
Department of Biological Sciences, University of Essex, Colchester, United Kingdom
Ann N Y Acad Sci 1126:280-2. 2008..Analysis of dG-G, dG-MG, and the oxidative marker 8-hydroxydeoxyguanosine in the DNA of cultured human cells and mononuclear leukocytes showed that nucleotide advanced glycation endproducts are major markers of DNA damage in human cells... - Assay of advanced glycation endproducts in selected beverages and food by liquid chromatography with tandem mass spectrometric detectionNaila Ahmed
Department of Biological Sciences, University of Essex, Colchester, UK
Mol Nutr Food Res 49:691-9. 2005..Experimental diabetes is associated with a marked increase in exposure to endogenous formation of methylglyoxal-derived hydroimidazolone which is linked to the development of diabetic nephropathy... - Idiopathic hypoalbuminemia explained by reduced synthesis rate and an increased catabolic rateBerthil H C M T Prinsen
Department of Vascular Medicine and Metabolism, University Medical Center, Utrecht, The Netherlands
Clin Biochem 35:545-53. 2002..To determine the contribution of albumin synthetic and catabolic rates to steady state levels in a patient with idiopathic hypoalbuminemia... - Increased formation of methylglyoxal and protein glycation, oxidation and nitrosation in triosephosphate isomerase deficiencyNaila Ahmed
Department of Biological Sciences, University of Essex, Central Campus, Wivenhoe Park, Colchester, Essex CO4 3SQ, UK
Biochim Biophys Acta 1639:121-32. 2003..The increased derangement of MG metabolism and associated glycation, oxidative and nitrosative stress in the propositus may be linked to neurodegenerative process in triosephosphate isomerase deficiency... - Methods for studying the binding of advanced glycated proteins to receptors for advanced glycation endproducts (AGE receptors)Paul J Thornalley
Department of Biological Sciences, Wivenhoe Park, University of Essex, Colchester, United Kingdom
Methods Mol Biol 196:49-62. 2002 - Methylglyoxal-derived hydroimidazolone advanced glycation end-products of human lens proteinsNaila Ahmed
Department of Biological Sciences, University of Essex, Central Campus, Wivenhoe Park, Colchester, Essex CO4 3SQ, United Kingdom
Invest Ophthalmol Vis Sci 44:5287-92. 2003..These substantial modifications of lens proteins may stimulate further glycation, oxidation, and protein aggregation leading to the formation of cataract... - Peptide mapping identifies hotspot site of modification in human serum albumin by methylglyoxal involved in ligand binding and esterase activityNaila Ahmed
Department of Biological Sciences, University of Essex, Colchester, Essex CO4 3SQ, UK
J Biol Chem 280:5724-32. 2005..Methylglyoxal modification of critical arginine residues, therefore, whether experimental or physiological, is expected to disrupt protein-ligand interactions and inactivate enzyme activity by hydroimidazolone formation... - Transcription factor Nrf2 is essential for induction of NAD(P)H:quinone oxidoreductase 1, glutathione S-transferases, and glutamate cysteine ligase by broccoli seeds and isothiocyanatesGail K McWalter
Biomedical Research Centre, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, United Kingdom
J Nutr 134:3499S-3506S. 2004..These experiments show that broccoli seeds are effective at inducing antioxidant and detoxication proteins, both in vivo and ex vivo, in an Nrf2-dependent manner... - Processing of protein glycation, oxidation and nitrosation adducts in the liver and the effect of cirrhosisNaila Ahmed
Department of Biological Sciences, University of Essex, Wivenhoe Park, Central Campus, Colchester, Essex CO4 3SQ, UK
J Hepatol 41:913-9. 2004.... - Nepsilon-(Carboxymethyl)lysine and 3-DG-imidazolone are major AGE structures in protein modification by 3-deoxyglucosoneTadashi Jono
Department of Medical Biochemistry, Graduate School of Medical and Pharmaceutical Sciences, Kumamoto University, Kumamoto, 860-0811, Japan
J Biochem (Tokyo) 136:351-8. 2004..Our results provide the first evidence that CML and 3-DG-imidazolone are major AGE structures in 3-DG-modified proteins, and that 3-DG-imidazolone provides a better marker for protein modification by 3-DG than pyrraline... - Glycation in diabetic neuropathy: characteristics, consequences, causes, and therapeutic optionsPaul J Thornalley
Department of Biological Sciences, University of Essex, Colchester, Essex CO4 3SQ, United Kingdom
Int Rev Neurobiol 50:37-57. 2002..Future possible therapeutic strategies are RAGE antagonists and inducers of the enzymatic antiglycation defense. More research is required to understand the role of glycation in the development of diabetic neuropathy... - Profound mishandling of protein glycation degradation products in uremia and dialysisStamatina Agalou
Department of Biological Sciences, University of Essex, Wivenhoe Park, Colchester, Essex CO4 3SQ, United Kingdom
J Am Soc Nephrol 16:1471-85. 2005..It is concluded that there are severe deficits of protein glycation free adduct clearance in chronic renal failure and in ESRD on PD and HD therapy... - Chromatographic assay of glycation adducts in human serum albumin glycated in vitro by derivatization with 6-aminoquinolyl-N-hydroxysuccinimidyl-carbamate and intrinsic fluorescenceNaila Ahmed
Department of Biological Sciences, University of Essex, Central Campus, Wivenhoe Park, Colchester, Essex CO4 3SQ, U.K
Biochem J 364:15-24. 2002..Significant proportions of arginine and lysine-derived AGEs in albumin modified highly by methylglyoxal, and lysine-derived AGEs in albumin modified highly by glucose, remain to be identified... - Dietary AGEs and ALEs and risk to human health by their interaction with the receptor for advanced glycation endproducts (RAGE)--an introductionPaul J Thornalley
Clinical Sciences Research Institute, University of Warwick, University Hospital, Coventry, UK
Mol Nutr Food Res 51:1107-10. 2007.... - Methylglyoxal administration induces diabetes-like microvascular changes and perturbs the healing process of cutaneous woundsJorge Berlanga
Centre for Genetic Engineering and Biotechnology, Ave 31 e 158 and 190 Playa 10600, Havana, Cuba
Clin Sci (Lond) 109:83-95. 2005..We conclude that exposure to increased MG in vivo is associated with the onset of microvascular damage and other diabetes-like complications within a normoglycaemic context... - Dicarbonyls linked to damage in the powerhouse: glycation of mitochondrial proteins and oxidative stressNaila Rabbani
Protein Damage and Systems Biology Research Group, Clinical Sciences Research Institute, Warwick Medical School, University of Warwick, University Hospital, Coventry CV2 2DX, UK
Biochem Soc Trans 36:1045-50. 2008..Future research will address the functional charges in mitochondrial proteins that are the targets for dicarbonyl glycation... - Assay of advanced glycation endproducts (AGEs): surveying AGEs by chromatographic assay with derivatization by 6-aminoquinolyl-N-hydroxysuccinimidyl-carbamate and application to Nepsilon-carboxymethyl-lysine- and Nepsilon-(1-carboxyethyl)lysine-modified aNaila Ahmed
Department of Biological Sciences, University of Essex, Central Campus, Wivenhoe Park, Colchester, Essex CO4 3SQ, U.K
Biochem J 364:1-14. 2002..The assay was applied to the characterization of human serum albumin minimally and highly modified by N(epsilon)-carboxymethyl-lysine and N(epsilon)-(1-carboxyethyl)-lysine... - Reversal of hyperglycemia-induced angiogenesis deficit of human endothelial cells by overexpression of glyoxalase 1 in vitroUsman Ahmed
Department of Biological Sciences, University of Essex, Colchester, United Kingdom
Ann N Y Acad Sci 1126:262-4. 2008..We conclude that increased protection against dicarbonyl glycation of endothelial cell protein protects hyperglycemia-induced angiogenesis deficit... - The dicarbonyl proteome: proteins susceptible to dicarbonyl glycation at functional sites in health, aging, and diseaseNaila Rabbani
Clinical Sciences Research Institute, Warwick Medical School, University of Warwick, Coventry CV2 2DX, UK
Ann N Y Acad Sci 1126:124-7. 2008.... - Assay of 3-nitrotyrosine in tissues and body fluids by liquid chromatography with tandem mass spectrometric detectionNaila Rabbani
Protein Damage and Systems Biology Research Group, Clinical Sciences Research Institute, Warwick Medical School, University of Warwick, University Hospital, Coventry, United Kingdom
Methods Enzymol 440:337-59. 2008..Changes of 3-nitrotyrosine residue and free 3-nitrotyrosine in diabetes, cirrhosis, acute and chronic renal failure, and neurological disorders, including Alzheimer's disease, are presented and compared with independent estimates... - Prevention of incipient diabetic nephropathy by high-dose thiamine and benfotiamineRoya Babaei-Jadidi
Department of Biological Sciences, University of Essex, Central Campus, Wivenhoe Park, Colchester, Essex, UK
Diabetes 52:2110-20. 2003..High-dose thiamine and benfotiamine therapy is a potential novel strategy for the prevention of clinical diabetic nephropathy... - Stimulation of suicidal erythrocyte death by methylglyoxalJan P Nicolay
Department of Physiology, , , Germany
Cell Physiol Biochem 18:223-32. 2006..In conclusion, methylglyoxal impairs energy production and anti-oxidative defense, effects contributing to the enhanced PS exposure of circulating erythrocytes and eventually resulting in anemia and deranged microcirculation... - Methylglyoxal modification of mSin3A links glycolysis to angiopoietin-2 transcriptionDachun Yao
JDRF International Center for Diabetic Complications Research, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Cell 124:275-86. 2006.... - Glycation, receptor-mediated cell activation and vascular complications of diabetesPaul J Thornalley
Diab Vasc Dis Res 1:21-2. 2004 - Analysis of glucosinolates, isothiocyanates, and amine degradation products in vegetable extracts and blood plasma by LC-MS/MSLijiang Song
Disease Mechanisms and Therapeutic Research Group, Department of Biological Sciences, University of Essex, Wivenhoe Park, Colchester, Essex CO4 3SQ, UK
Anal Biochem 347:234-43. 2005..These methods provide facile access to comprehensive analytical data on the major dietary glucosinolates and related metabolites to quantify inputs and metabolic formation of these compounds in cancer prevention and related studies... - Glycated and oxidized protein degradation products are indicators of fasting and postprandial hyperglycemia in diabetesNaila Ahmed
Department of Biological Sciences, University of Essex, Colchester, UK
Diabetes Care 28:2465-71. 2005.... - Glycation free adduct accumulation in renal disease: the new AGEPaul J Thornalley
Pediatr Nephrol 20:1515-22. 2005..AGE free adducts may also contribute to vascular disease in uraemia. They represent an important new age for glycation research in nephrology... - Protein glycation, oxidation and nitration adduct residues and free adducts of cerebrospinal fluid in Alzheimer's disease and link to cognitive impairmentNaila Ahmed
Department of Biological Sciences, University of Essex, Colchester, Essex, UK
J Neurochem 92:255-63. 2005..A combination of nitration and glycation adduct estimates of CSF may provide an indicator for the diagnosis of Alzheimer's disease... - Increased dicarbonyl metabolism in endothelial cells in hyperglycemia induces anoikis and impairs angiogenesis by RGD and GFOGER motif modificationDarin Dobler
Department of Biological Sciences, University of Essex, Colchester, Essex CO4 3SQ, UK
Diabetes 55:1961-9. 2006..Thus, increased formation of methylglyoxal and ECM glycation in hyperglycemia impairs endothelial cell survival and angiogenesis and likely contributes to similar vascular dysfunction in diabetes...