P Thorn

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. ncbi request reprint Spatial domains of Ca2+ signaling in secretory epithelial cells
    P Thorn
    Department of Pharmacology, University of Cambridge, UK
    Cell Calcium 20:203-14. 1996
  2. pmc Two phases of zymogen granule lifetime in mouse pancreas: ghost granules linger after exocytosis of contents
    Peter Thorn
    Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, UK
    J Physiol 563:433-42. 2005
  3. pmc Zymogen granule exocytosis is characterized by long fusion pore openings and preservation of vesicle lipid identity
    Peter Thorn
    Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, United Kingdom
    Proc Natl Acad Sci U S A 101:6774-9. 2004
  4. ncbi request reprint Activation of Ca(2+)- and cAMP-sensitive K(+) channels in murine colonic epithelia by 1-ethyl-2-benzimidazolone
    A W Cuthbert
    Department of Pharmacology, University of Cambridge, Cambridge CB2 1QJ, United Kingdom
    Am J Physiol 277:C111-20. 1999
  5. ncbi request reprint Calcium signalling: IP3 rises again...and again
    C W Taylor
    Department of Pharmacology, Tennis Court Road, CB2 1QJ, Cambridge
    Curr Biol 11:R352-5. 2001
  6. ncbi request reprint The plasma membrane Q-SNARE syntaxin 2 enters the zymogen granule membrane during exocytosis in the pancreatic acinar cell
    James A Pickett
    Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, United Kingdom
    J Biol Chem 280:1506-11. 2005
  7. ncbi request reprint Modulation of IP(3)-sensitive Ca(2+) release by 2,3-butanedione monoxime
    Matthew R Turvey
    Department of Pharmacology, Tennis Court Road, CB2 1PD, Cambridge, UK
    Pflugers Arch 445:614-21. 2003
  8. pmc Syncollin is required for efficient zymogen granule exocytosis
    Barbara Wäsle
    Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, UK
    Biochem J 385:721-7. 2005
  9. pmc Dynamic regulation of the large exocytotic fusion pore in pancreatic acinar cells
    Olga Larina
    Department of Pharmacology, University of Cambridge, Cambridge, CB2 1PD, United Kingdom
    Mol Biol Cell 18:3502-11. 2007
  10. ncbi request reprint Carbachol-stimulated chloride secretion in mouse colon: evidence of a role for autocrine prostaglandin E2 release
    M A Carew
    Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QJ, UK
    Exp Physiol 85:67-72. 2000

Collaborators

Detail Information

Publications18

  1. ncbi request reprint Spatial domains of Ca2+ signaling in secretory epithelial cells
    P Thorn
    Department of Pharmacology, University of Cambridge, UK
    Cell Calcium 20:203-14. 1996
    ..The [Ca2+]i signal within a single microdomain has been shown to be the crucial trigger in the regulation of the ion channels important in fluid secretion...
  2. pmc Two phases of zymogen granule lifetime in mouse pancreas: ghost granules linger after exocytosis of contents
    Peter Thorn
    Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, UK
    J Physiol 563:433-42. 2005
    ....
  3. pmc Zymogen granule exocytosis is characterized by long fusion pore openings and preservation of vesicle lipid identity
    Peter Thorn
    Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, United Kingdom
    Proc Natl Acad Sci U S A 101:6774-9. 2004
    ..The lack of lipid intermixing may then facilitate selective recycling of granule membrane and preservation of apical membrane integrity...
  4. ncbi request reprint Activation of Ca(2+)- and cAMP-sensitive K(+) channels in murine colonic epithelia by 1-ethyl-2-benzimidazolone
    A W Cuthbert
    Department of Pharmacology, University of Cambridge, Cambridge CB2 1QJ, United Kingdom
    Am J Physiol 277:C111-20. 1999
    ..CFTR is also activated by the accumulation of cAMP as well as by direct activation...
  5. ncbi request reprint Calcium signalling: IP3 rises again...and again
    C W Taylor
    Department of Pharmacology, Tennis Court Road, CB2 1QJ, Cambridge
    Curr Biol 11:R352-5. 2001
    ....
  6. ncbi request reprint The plasma membrane Q-SNARE syntaxin 2 enters the zymogen granule membrane during exocytosis in the pancreatic acinar cell
    James A Pickett
    Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, United Kingdom
    J Biol Chem 280:1506-11. 2005
    ..We conclude that syntaxin 2 enters the membrane of a fused zymogen granule after the opening of the fusion pore, and we suggest that this movement might permit the onset of secondary fusion...
  7. ncbi request reprint Modulation of IP(3)-sensitive Ca(2+) release by 2,3-butanedione monoxime
    Matthew R Turvey
    Department of Pharmacology, Tennis Court Road, CB2 1PD, Cambridge, UK
    Pflugers Arch 445:614-21. 2003
    ..We conclude that BDM cannot be used for unequivocal identification of the involvement of myosin motors in a cellular response. Further, our evidence suggests that BDM can act directly to modify the opening of IP(3) receptors...
  8. pmc Syncollin is required for efficient zymogen granule exocytosis
    Barbara Wäsle
    Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, UK
    Biochem J 385:721-7. 2005
    ..We conclude that syncollin is required for efficient exocytosis in the pancreatic acinar cell, and that it plays a particularly important role in compound exocytosis...
  9. pmc Dynamic regulation of the large exocytotic fusion pore in pancreatic acinar cells
    Olga Larina
    Department of Pharmacology, University of Cambridge, Cambridge, CB2 1PD, United Kingdom
    Mol Biol Cell 18:3502-11. 2007
    ..Instead, for many granules the fusion pore closes, probably as a transition to endocytosis, and likely involving an F-actin-dependent mechanism...
  10. ncbi request reprint Carbachol-stimulated chloride secretion in mouse colon: evidence of a role for autocrine prostaglandin E2 release
    M A Carew
    Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QJ, UK
    Exp Physiol 85:67-72. 2000
    ..We conclude that autocrine release of PGs from epithelial cells is sufficient to support the CCh-induced Cl- secretory response and is a likely co-factor in this response...
  11. ncbi request reprint Inositol (1,4,5)-trisphosphate receptor links to filamentous actin are important for generating local Ca2+ signals in pancreatic acinar cells
    Matthew R Turvey
    Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge, CB2 IPD, UK
    J Cell Sci 118:971-80. 2005
    ..Based on these findings, we suggest that IP(3)Rs form links with F-actin in the apical domain and that these links are essential for the generation of local Ca(2+) spikes...
  12. ncbi request reprint Lysine-fixable dye tracing of exocytosis shows F-actin coating is a step that follows granule fusion in pancreatic acinar cells
    Matthew R Turvey
    Department of Pharmacology, University of Cambridge, Tennis Court Road, CB2 1PD, Cambridge, UK
    Pflugers Arch 448:552-5. 2004
    ..The results show that F-actin coating is associated specifically with dye-filled granules and therefore is a step that follows exocytosis...
  13. ncbi request reprint The properties of the secretagogue-evoked chloride current in mouse pancreatic acinar cells
    J F Kidd
    Department of Pharmacology, University of Cambridge, UK
    Pflugers Arch 441:489-97. 2001
    ..We conclude that the agonist-evoked rise in Ca2+ is alone a sufficient signal to activate the CL- current...
  14. ncbi request reprint Regulation of adenylyl cyclase by membrane potential
    D M Cooper
    Department of Pharmacology, University of Cambridge, Cambridge CB2 1QJ, United Kingdom
    J Biol Chem 273:27703-7. 1998
    ....
  15. ncbi request reprint Ca2+ dynamics in salivary acinar cells: distinct morphology of the acinar lumen underlies near-synchronous global Ca2+ responses
    Olga Larina
    Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, UK
    J Cell Sci 118:4131-9. 2005
    ..We suggest that this may be a structural adaptation in submandibular cells to support the copious amounts of fluid secreted...
  16. ncbi request reprint The structural integrity of the endoplasmic reticulum, and its possible regulation by inositol 1,3,4,5-tetrakisphosphate
    David Brough
    Department of Pharmacology, Cambridge, UK
    Cell Calcium 38:153-9. 2005
    ..However, we were subsequently unable to detect by FRAP any significant effect of Ins(1,3,4,5)P(4) on ER integrity...
  17. ncbi request reprint Paclitaxel affects cytosolic calcium signals by opening the mitochondrial permeability transition pore
    Jackie F Kidd
    Biomedical Imaging Group, Department of Physiology, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    J Biol Chem 277:6504-10. 2002
    ..This work indicates that some of the more rapidly developing side effects of chemotherapy might be due to an action of antimitotic drugs on mitochondrial function and an interference with the Ca(2+) signal cascade...
  18. ncbi request reprint A constitutively active nonselective cation conductance underlies resting Ca2+ influx and secretion in bovine adrenal chromaffin cells
    Timothy R Cheek
    Institute for Cell and Molecular Biosciences, University of Newcastle upon Tyne, The Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH, UK
    Cell Calcium 40:309-18. 2006
    ....