M Thoresen

Summary

Affiliation: University of Bristol
Country: UK

Publications

  1. ncbi request reprint The pathogenesis of neonatal post-hemorrhagic hydrocephalus
    Shobha Cherian
    Department of Clinical Science at South Bristol, University of Bristol, United Kingdom
    Brain Pathol 14:305-11. 2004
  2. doi request reprint Immediate hypothermia is not neuroprotective after severe hypoxia-ischemia and is deleterious when delayed by 12 hours in neonatal rats
    Hemmen Sabir
    School of Clinical Sciences, University of Bristol, St Michael s Hospital, Bristol, BS28EG, United Kingdom
    Stroke 43:3364-70. 2012
  3. doi request reprint Lactate dehydrogenase in hypothermia-treated newborn infants with hypoxic-ischaemic encephalopathy
    Marianne Thoresen
    School of Clinical Sciences, University of Bristol, Bristol, UK
    Acta Paediatr 101:1038-44. 2012
  4. pmc The TOBY Study. Whole body hypothermia for the treatment of perinatal asphyxial encephalopathy: a randomised controlled trial
    Dennis Azzopardi
    Division of Clinical Sciences, Faculty of Medicine, Imperial College London, UK
    BMC Pediatr 8:17. 2008
  5. doi request reprint Patient selection and prognostication with hypothermia treatment
    Marianne Thoresen
    Department of Child Health, University of Bristol, Level D, Child Health, St Michael s Hospital, Bristol BS2 8EG, UK
    Semin Fetal Neonatal Med 15:247-52. 2010
  6. doi request reprint Effect of hypothermia on amplitude-integrated electroencephalogram in infants with asphyxia
    Marianne Thoresen
    Department of Child Health, University of Bristol, Bristol, UK
    Pediatrics 126:e131-9. 2010
  7. doi request reprint Hypothermia after perinatal asphyxia: selection for treatment and cooling protocol
    Marianne Thoresen
    Department of Child Health, University of Bristol, Bristol, United Kingdom
    J Pediatr 158:e45-9. 2011
  8. ncbi request reprint Therapeutic hypothermia for hypoxic-ischaemic encephalopathy in the newborn infant
    Marianne Thoresen
    Department of Clinical Science, University of Bristol, Bristol, UK
    Curr Opin Neurol 18:111-6. 2005
  9. ncbi request reprint Effective selective head cooling during posthypoxic hypothermia in newborn piglets
    M Thoresen
    Department of Child Health, St Michael s Hospital, Level D, Southwell Street, University of Bristol, Bristol BS2 8EG, U K
    Pediatr Res 49:594-9. 2001
  10. pmc Significant head cooling can be achieved while maintaining normothermia in the newborn piglet
    J R Tooley
    Department of Child Health, St Michael s Hospital, Southwell Street, Bristol BS2 8EG, UK
    Arch Dis Child Fetal Neonatal Ed 90:F262-6. 2005

Collaborators

Detail Information

Publications47

  1. ncbi request reprint The pathogenesis of neonatal post-hemorrhagic hydrocephalus
    Shobha Cherian
    Department of Clinical Science at South Bristol, University of Bristol, United Kingdom
    Brain Pathol 14:305-11. 2004
    ..The identification of mechanisms and mediators of hydrocephalus and white matter damage is leading to the development of new treatments to prevent permanent hydrocephalus and its neurological complications, and to avoid shunt dependence...
  2. doi request reprint Immediate hypothermia is not neuroprotective after severe hypoxia-ischemia and is deleterious when delayed by 12 hours in neonatal rats
    Hemmen Sabir
    School of Clinical Sciences, University of Bristol, St Michael s Hospital, Bristol, BS28EG, United Kingdom
    Stroke 43:3364-70. 2012
    ..There is some clinical evidence that HT is more effective against moderate than against severe hypoxic-ischemic encephalopathy, but it is unknown whether delayed HT beyond 6 hours is effective or even injurious...
  3. doi request reprint Lactate dehydrogenase in hypothermia-treated newborn infants with hypoxic-ischaemic encephalopathy
    Marianne Thoresen
    School of Clinical Sciences, University of Bristol, Bristol, UK
    Acta Paediatr 101:1038-44. 2012
    ....
  4. pmc The TOBY Study. Whole body hypothermia for the treatment of perinatal asphyxial encephalopathy: a randomised controlled trial
    Dennis Azzopardi
    Division of Clinical Sciences, Faculty of Medicine, Imperial College London, UK
    BMC Pediatr 8:17. 2008
    ..5 degrees C have been reported. No complications were noted but the group sizes were too small to evaluate benefit...
  5. doi request reprint Patient selection and prognostication with hypothermia treatment
    Marianne Thoresen
    Department of Child Health, University of Bristol, Level D, Child Health, St Michael s Hospital, Bristol BS2 8EG, UK
    Semin Fetal Neonatal Med 15:247-52. 2010
    ..The main focus is on convenient bedside technologies such as the amplitude-integrated electroencephalogram that can be easily applied in routine clinical practice...
  6. doi request reprint Effect of hypothermia on amplitude-integrated electroencephalogram in infants with asphyxia
    Marianne Thoresen
    Department of Child Health, University of Bristol, Bristol, UK
    Pediatrics 126:e131-9. 2010
    ....
  7. doi request reprint Hypothermia after perinatal asphyxia: selection for treatment and cooling protocol
    Marianne Thoresen
    Department of Child Health, University of Bristol, Bristol, United Kingdom
    J Pediatr 158:e45-9. 2011
    ..HT is a time-critical emergency treatment after perinatal asphyxia that requires optimal collaboration among local hospitals, transport teams, and cooling centers...
  8. ncbi request reprint Therapeutic hypothermia for hypoxic-ischaemic encephalopathy in the newborn infant
    Marianne Thoresen
    Department of Clinical Science, University of Bristol, Bristol, UK
    Curr Opin Neurol 18:111-6. 2005
    ..This review examines recent findings from experimental models and clinical trials of induced hypothermia as treatment after cerebral hypoxia-ischaemia in term newborn infants...
  9. ncbi request reprint Effective selective head cooling during posthypoxic hypothermia in newborn piglets
    M Thoresen
    Department of Child Health, St Michael s Hospital, Level D, Southwell Street, University of Bristol, Bristol BS2 8EG, U K
    Pediatr Res 49:594-9. 2001
    ..5 degrees C. We report for the first time a study, which by direct measurement of deep intracerebral temperatures, validates the cooling cap as an effective method of selective brain cooling in a newborn animal hypoxia-ischemia model...
  10. pmc Significant head cooling can be achieved while maintaining normothermia in the newborn piglet
    J R Tooley
    Department of Child Health, St Michael s Hospital, Southwell Street, Bristol BS2 8EG, UK
    Arch Dis Child Fetal Neonatal Ed 90:F262-6. 2005
    ..It is hypothesised that selective head cooling (SHC) while maintaining normal core temperature would enable local hypothermic neuroprotection while limiting the stress and side effects of hypothermia...
  11. doi request reprint A comparison of cooling methods used in therapeutic hypothermia for perinatal asphyxia
    Nicholas Hoque
    Child Health, School of Clinical Sciences, University of Bristol, St Michael s Hospital, Bristol, Avon, UK
    Pediatrics 126:e124-30. 2010
    ..The objective of this study was to compare cooling methods during therapeutic hypothermia (TH) for moderate or severe perinatal asphyxia with regard to temperature and hemodynamic stability...
  12. ncbi request reprint Cooling the newborn after asphyxia - physiological and experimental background and its clinical use
    M Thoresen
    St Michael s Hospital, Dept of Child Health, University of Bristol, UK
    Semin Neonatol 5:61-73. 2000
    ..Different enzymes have different sensitivity to changes in temperature, hence some effects may be beneficial and some deleterious. Hypothermia and cardiovascular responses and coagulation needs careful monitoring...
  13. ncbi request reprint Posthaemorrhagic ventricular dilatation: new mechanisms and new treatment
    A Whitelaw
    Division of Child Health, University of Bristol Medical School, Southmead Hospital, Bristol, UK
    Acta Paediatr Suppl 93:11-4. 2004
    ..We have piloted drainage, irrigation and fibrinolytic therapy as a way of removing blood early enough to stop the progressive deposition of matrix proteins, permanent hydrocephalus and shunt dependence...
  14. pmc Posthaemorrhagic ventricular dilatation
    A Whitelaw
    Division of Child Health, University of Bristol, Bristol, UK
    Arch Dis Child Fetal Neonatal Ed 86:F72-4. 2002
    ..It results initially from multiple small blood clots throughout the cerebrospinal fluid channels impeding circulation and reabsorption. Management is difficult and new treatment approaches are needed...
  15. pmc Antenatal steroids and the developing brain
    A Whitelaw
    Division of Child Health, University of Bristol Medical School, Southmead Hospital, Bristol BS10 5NB, UK
    Arch Dis Child Fetal Neonatal Ed 83:F154-7. 2000
    ..In view of the animal and postnatal data, clinicians should be cautious with repeated courses of antenatal corticosteroids and repetition may be unnecessary for lung maturity...
  16. ncbi request reprint Clinical trials of treatments after perinatal asphyxia
    Andrew Whitelaw
    Division of Child Health, University of Bristol, Bristol, United Kingdom
    Curr Opin Pediatr 14:664-8. 2002
    ..As time is critical with post-hypoxic interventions, the delay involved in obtaining informed parental consent for such trials might obscure a clinically important therapeutic effect...
  17. ncbi request reprint Randomized clinical trial of prevention of hydrocephalus after intraventricular hemorrhage in preterm infants: brain-washing versus tapping fluid
    Andrew Whitelaw
    Department of Clinical Science at North Bristol, University of Bristol, Bristol, United Kingdom
    Pediatrics 119:e1071-8. 2007
    ..The aim of this study was to test a new treatment intended to prevent hydrocephalus and shunt dependence after intraventricular hemorrhage...
  18. ncbi request reprint Phase 1 trial of prevention of hydrocephalus after intraventricular hemorrhage in newborn infants by drainage, irrigation, and fibrinolytic therapy
    Andrew Whitelaw
    Division of Child Health, University of Bristol, Bristol, United Kingdom
    Pediatrics 111:759-65. 2003
    ..Treatment of posthemorrhagic ventricular dilation in premature infants is fraught with failures and complications. We have piloted a new treatment aimed at removing intraventricular blood and the cytokines associated with hydrocephalus...
  19. doi request reprint Xenon enhances hypothermic neuroprotection in asphyxiated newborn pigs
    Elavazhagan Chakkarapani
    Department of Clinical Sciences at South Bristol, University of Bristol, Bristol, United Kingdom
    Ann Neurol 68:330-41. 2010
    ..To investigate whether inhaling 50% xenon during hypothermia (HT) offers better neuroprotection than xenon or HT alone...
  20. doi request reprint Supportive care during neuroprotective hypothermia in the term newborn: adverse effects and their prevention
    Marianne Thoresen
    Child Health, St Michael s Hospital, Level D, University of Bristol, Bristol, UK
    Clin Perinatol 35:749-63, vii. 2008
    ..The practical cooling recommendations suggested herein are therefore likely to develop and change over time as more experience is gained...
  21. doi request reprint Neonatal rat model of intraventricular haemorrhage and post-haemorrhagic ventricular dilatation with long-term survival into adulthood
    K Aquilina
    School of Clinical Sciences, University of Bristol Department of Neurosurgery, Frenchay Hospital, Bristol, UK
    Neuropathol Appl Neurobiol 37:156-65. 2011
    ..Our objective is to evaluate survival, to adulthood, in our immature (7-day-old, P7) neonatal rat model, and to analyse early motor reflexes and fine motor and cognitive function, and neuropathology, at 8-12 weeks...
  22. ncbi request reprint A neonatal piglet model of intraventricular hemorrhage and posthemorrhagic ventricular dilation
    Kristian Aquilina
    Department of Child Health, University of Bristol, Clinical Sciences at South Bristol, United Kingdom
    J Neurosurg 107:126-36. 2007
    ..The authors have developed a neonatal large animal model of IVH with long-term survival, allowing the full development of PHVD...
  23. doi request reprint Xenon and hypothermia combine additively, offering long-term functional and histopathologic neuroprotection after neonatal hypoxia/ischemia
    Catherine Hobbs
    Department of Clinical Sciences at South Bristol, University of Bristol, Bristol, UK
    Stroke 39:1307-13. 2008
    ..We investigated combinations of 50% xenon (Xe(50%)) and hypothermia of 32 degrees C (HT(32 degrees C)) as a post-HI therapy...
  24. doi request reprint Xenon/hypothermia neuroprotection regimes in spontaneously breathing neonatal rats after hypoxic-ischemic insult: the respiratory and sedative effects
    John Dingley
    Clinical Science at South Bristol, Child Health, University of Bristol, St Michael s Hospital, Bristol, UK
    Anesth Analg 106:916-23, table of contents. 2008
    ....
  25. doi request reprint Serum gentamicin concentrations in encephalopathic infants are not affected by therapeutic hypothermia
    Xun Liu
    Department of Child Health, St Michael s Hospital, University of Bristol, Bristol, United Kingdom
    Pediatrics 124:310-5. 2009
    ..We aimed to compare the SGCs in encephalopathic infants who underwent intensive care with therapeutic hypothermia or normothermia...
  26. doi request reprint Delayed hypothermia as selective head cooling or whole body cooling does not protect brain or body in newborn pig subjected to hypoxia-ischemia
    Mathias Karlsson
    Clinical Science at South Bristol Child Health, University of Bristol, Bristol, BS2 8EG, United Kingdom
    Pediatr Res 64:74-8. 2008
    ..Delayed HT improves postinsult recovery of plasma-calcium, magnesium, and potassium. There were no differences in adverse effects across groups...
  27. doi request reprint Minimum alveolar concentration (MAC) for sevoflurane and xenon at normothermia and hypothermia in newborn pigs
    X Liu
    Neonatal Neuroscience, School of Clinical Sciences, University of Bristol, Bristol, UK
    Acta Anaesthesiol Scand 57:646-53. 2013
    ..Minimum alveolar concentration (MAC) of xenon is unknown in any neonatal species...
  28. ncbi request reprint Transforming growth factor-betas in a rat model of neonatal posthaemorrhagic hydrocephalus
    S Cherian
    Department of Clinical Science South Bristol, University of Bristol, Bristol, UK
    Neuropathol Appl Neurobiol 30:585-600. 2004
    ....
  29. ncbi request reprint Posthemorrhagic ventricular dilation in the neonate: development and characterization of a rat model
    Shobha S Cherian
    Division of Child Health, St Michael s Hospital, Bristol, United Kingdom
    J Neuropathol Exp Neurol 62:292-303. 2003
    ..001). Body weights were not significantly different from controls. Hydrocephalic animals had reduced motor performance as assessed by a grip traction test (p = 0.0002). This model is well suited to studying the pathogenesis of PHVD...
  30. ncbi request reprint Effects of hypothermia on energy metabolism in Mammalian central nervous system
    Maria Erecinska
    Department of Anatomy, University of Bristol, Bristol, United Kingdom
    J Cereb Blood Flow Metab 23:513-30. 2003
    ..Hypothermia may thus prove a promising avenue in the treatment of stroke and trauma and, in particular, of perinatal brain injury...
  31. ncbi request reprint Head cooling with mild systemic hypothermia in anesthetized piglets is neuroprotective
    James R Tooley
    Department of Child Health, St Michael s Hospital, University of Bristol, United Kingdom
    Ann Neurol 53:65-72. 2003
    ..We conclude that selective head cooling combined with mild systemic hypothermia and anesthesia is neuroprotective when started immediately after the insult in our piglet model of hypoxic-ischemic encephalopathy...
  32. ncbi request reprint Significant selective head cooling can be maintained long-term after global hypoxia ischemia in newborn piglets
    James Tooley
    Department of Child Health, St Michael s Hospital, University of Bristol, Bristol, United Kingdom
    Pediatrics 109:643-9. 2002
    ..The aim of this study was to examine whether the brain (T(deep brain)) could be cooled to below the rectal temperature (T(rectal)) in our piglet hypoxia ischemia (HI) model for a period of 24 hours, using a head-cooling cap...
  33. doi request reprint Do drugs that block transforming growth factor beta reduce posthaemorrhagic ventricular dilatation in a neonatal rat model?
    Kristian Aquilina
    Department of Clinical Science at South Bristol, University of Bristol, Bristol, United Kingdom
    Acta Paediatr 97:1181-6. 2008
    ..They have excellent CSF and brain penetration. We hypothesized that administration of pirfenidone or losartan would reduce ventricular dilatation...
  34. doi request reprint A closed-circuit neonatal xenon delivery system: a technical and practical neuroprotection feasibility study in newborn pigs
    Ela Chakkarapani
    Department of Clinical Sciences at South Bristol, Universityof Bristol, Bristol, United Kingdom
    Anesth Analg 109:451-60. 2009
    ....
  35. doi request reprint Cooling combined with immediate or delayed xenon inhalation provides equivalent long-term neuroprotection after neonatal hypoxia-ischemia
    Marianne Thoresen
    Department of Clinical Sciences at South Bristol, University of Bristol, Bristol, UK
    J Cereb Blood Flow Metab 29:707-14. 2009
    ..024). Females had significantly better motor scores than males, but no sex-dependent difference in pathology results. The neuroprotection of short, delayed Xe treatment would allow transport to specialist facilities to receive Xe...
  36. doi request reprint Development of amplitude-integrated electroencephalography and interburst interval in the rat
    Alexander M Tucker
    Department of Child Health, University of Bristol, Bristol, BS2 8EG, United Kingdom
    Pediatr Res 65:62-6. 2009
    ..Based on aEEG trace analysis, the rat aEEG pattern at P1 corresponds to human aEEG at 23-wk gestation; P7 corresponds to 30-32 wk and P10 to 40-42 wk...
  37. ncbi request reprint Mild hypothermia and the distribution of cerebral lesions in neonates with hypoxic-ischemic encephalopathy
    Mary A Rutherford
    Imaging Sciences Department, Imperial College, Hammersmith Hospital, London, United Kingdom
    Pediatrics 116:1001-6. 2005
    ..This decrease was significant in infants with a moderate aEEG finding but not in those with a severe aEEG finding. A decrease in the incidence of severe cortical lesions was seen in the infants treated with SHC...
  38. doi request reprint Hypothermia: an evolving treatment for neonatal hypoxic ischemic encephalopathy
    Alistair J Gunn
    Pediatrics 121:648-9; author reply 649-50. 2008
  39. ncbi request reprint Xenon provides short-term neuroprotection in neonatal rats when administered after hypoxia-ischemia
    John Dingley
    University of Wales Swansea, United Kingdom
    Stroke 37:501-6. 2006
    ..We sought to determine whether xenon administration after the initial hypoxic-ischemic insult was neuroprotective...
  40. ncbi request reprint Hypothermia and perinatal asphyxia: executive summary of the National Institute of Child Health and Human Development workshop
    Rosemary D Higgins
    Pregnancy and Perinatology Branch, Center for Developmental Biology and Perinatal Medicine, National Institute of Child Health and Human Development NIH, 6100 Executive Boulevard, MSC 7510, Bethesda, MD 20892, USA
    J Pediatr 148:170-175. 2006
  41. doi request reprint Therapeutic hypothermia in neonates. Review of current clinical data, ILCOR recommendations and suggestions for implementation in neonatal intensive care units
    Thomas Hoehn
    Neonatology and Pediatric Intensive Care Medicine, Department of General Pediatrics, Heinrich Heine University, Duesseldorf, Germany
    Resuscitation 78:7-12. 2008
    ....
  42. ncbi request reprint Selective head cooling with mild systemic hypothermia after neonatal encephalopathy: multicentre randomised trial
    Peter D Gluckman
    The Liggins Institute, University of Auckland, Auckland, New Zealand
    Lancet 365:663-70. 2005
    ..We did a multicentre randomised controlled trial to find out if delayed head cooling can improve neurodevelopmental outcome in babies with neonatal encephalopathy...
  43. ncbi request reprint Analysis of neuronal, glial, endothelial, axonal and apoptotic markers following moderate therapeutic hypothermia and anesthesia in the developing piglet brain
    Pierre Gressens
    INSERM, U676, Paris, France
    Brain Pathol 18:10-20. 2008
    ..Longer survival studies are necessary to verify the safety of hypothermia in the developing brain...
  44. ncbi request reprint Non-protein-bound iron in brain interstitium of newborn pigs after hypoxia
    Karin Savman
    Department of Pediatrics, Perinatal Center, Goteborg University, The Queen Silvia Children s Hospital, Goteborg, Sweden
    Dev Neurosci 27:176-84. 2005
    ..97 (0.69) to 2.75 (1.85) micromol/l (not corrected for recovery rate) during early reoxygenation. NPBI may contribute to oxidative injury after perinatal hypoxic insults...
  45. ncbi request reprint Translational stroke research in the developing brain
    Zinaida S Vexler
    Department of Neurology, University of California San Francisco, San Francisco, California 94143 0663, USA
    Pediatr Neurol 34:459-63. 2006
    ..These issues need to be carefully addressed in designing future clinical trials...
  46. ncbi request reprint Determinants of outcomes after head cooling for neonatal encephalopathy
    John S Wyatt
    Department of Paediatrics and Child Health, University College London, London, United Kingdom
    Pediatrics 119:912-21. 2007
    ..The goal of this study was to evaluate the role of factors that may determine the efficacy of treatment with delayed head cooling and mild systemic hypothermia for neonatal encephalopathy...
  47. ncbi request reprint Therapeutic hypothermia changes the prognostic value of clinical evaluation of neonatal encephalopathy
    Alistair J Gunn
    Department of Physiology, University of Auckland, Auckland, New Zealand
    J Pediatr 152:55-8, 58.e1. 2008
    ..To evaluate whether therapeutic hypothermia alters the prognostic value of clinical grading of neonatal encephalopathy...