Research Topics
| M ThoresenSummaryAffiliation: University of Bristol Country: UK Publications
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Detail Information
Publications
The pathogenesis of neonatal post-hemorrhagic hydrocephalusShobha Cherian
Department of Clinical Science at South Bristol, University of Bristol, United Kingdom
Brain Pathol 14:305-11. 2004..The identification of mechanisms and mediators of hydrocephalus and white matter damage is leading to the development of new treatments to prevent permanent hydrocephalus and its neurological complications, and to avoid shunt dependence...
Immediate hypothermia is not neuroprotective after severe hypoxia-ischemia and is deleterious when delayed by 12 hours in neonatal ratsHemmen Sabir
School of Clinical Sciences, University of Bristol, St Michael s Hospital, Bristol, BS28EG, United Kingdom
Stroke 43:3364-70. 2012..There is some clinical evidence that HT is more effective against moderate than against severe hypoxic-ischemic encephalopathy, but it is unknown whether delayed HT beyond 6 hours is effective or even injurious...- Lactate dehydrogenase in hypothermia-treated newborn infants with hypoxic-ischaemic encephalopathyMarianne Thoresen
School of Clinical Sciences, University of Bristol, Bristol, UK
Acta Paediatr 101:1038-44. 2012.... 
The TOBY Study. Whole body hypothermia for the treatment of perinatal asphyxial encephalopathy: a randomised controlled trialDennis Azzopardi
Division of Clinical Sciences, Faculty of Medicine, Imperial College London, UK
BMC Pediatr 8:17. 2008....- Therapeutic hypothermia for hypoxic-ischaemic encephalopathy in the newborn infantMarianne Thoresen
Department of Clinical Science, University of Bristol, Bristol, UK
Curr Opin Neurol 18:111-6. 2005..This review examines recent findings from experimental models and clinical trials of induced hypothermia as treatment after cerebral hypoxia-ischaemia in term newborn infants... - Effective selective head cooling during posthypoxic hypothermia in newborn pigletsM Thoresen
Department of Child Health, St Michael s Hospital, Level D, Southwell Street, University of Bristol, Bristol BS2 8EG, U K
Pediatr Res 49:594-9. 2001..5 degrees C. We report for the first time a study, which by direct measurement of deep intracerebral temperatures, validates the cooling cap as an effective method of selective brain cooling in a newborn animal hypoxia-ischemia model... - Hypothermia after perinatal asphyxia: selection for treatment and cooling protocolMarianne Thoresen
Department of Child Health, University of Bristol, Bristol, United Kingdom
J Pediatr 158:e45-9. 2011..HT is a time-critical emergency treatment after perinatal asphyxia that requires optimal collaboration among local hospitals, transport teams, and cooling centers... - Effect of hypothermia on amplitude-integrated electroencephalogram in infants with asphyxiaMarianne Thoresen
Department of Child Health, University of Bristol, Bristol, UK
Pediatrics 126:e131-9. 2010.... - Patient selection and prognostication with hypothermia treatmentMarianne Thoresen
Department of Child Health, University of Bristol, Level D, Child Health, St Michael s Hospital, Bristol BS2 8EG, UK
Semin Fetal Neonatal Med 15:247-52. 2010..The main focus is on convenient bedside technologies such as the amplitude-integrated electroencephalogram that can be easily applied in routine clinical practice... - Significant head cooling can be achieved while maintaining normothermia in the newborn pigletJ R Tooley
Department of Child Health, St Michael's Hospital, Southwell Street, Bristol BS2 8EG, UK
Arch Dis Child Fetal Neonatal Ed 90:F262-6. 2005..This method of cooling may further limit the side effects associated with systemic hypothermia and be feasible for premature infants... - A comparison of cooling methods used in therapeutic hypothermia for perinatal asphyxiaNicholas Hoque
Child Health, School of Clinical Sciences, University of Bristol, St Michael s Hospital, Bristol, Avon, UK
Pediatrics 126:e124-30. 2010..The objective of this study was to compare cooling methods during therapeutic hypothermia (TH) for moderate or severe perinatal asphyxia with regard to temperature and hemodynamic stability... - Cooling the newborn after asphyxia - physiological and experimental background and its clinical useM Thoresen
St Michael s Hospital, Dept of Child Health, University of Bristol, UK
Semin Neonatol 5:61-73. 2000..Different enzymes have different sensitivity to changes in temperature, hence some effects may be beneficial and some deleterious. Hypothermia and cardiovascular responses and coagulation needs careful monitoring... - Posthaemorrhagic ventricular dilatation: new mechanisms and new treatmentA Whitelaw
Division of Child Health, University of Bristol Medical School, Southmead Hospital, Bristol, UK
Acta Paediatr Suppl 93:11-4. 2004..We have piloted drainage, irrigation and fibrinolytic therapy as a way of removing blood early enough to stop the progressive deposition of matrix proteins, permanent hydrocephalus and shunt dependence... - Antenatal steroids and the developing brainA Whitelaw
Division of Child Health, University of Bristol Medical School, Southmead Hospital, Bristol BS10 5NB, UK
Arch Dis Child Fetal Neonatal Ed 83:F154-7. 2000..In view of the animal and postnatal data, clinicians should be cautious with repeated courses of antenatal corticosteroids and repetition may be unnecessary for lung maturity... - Posthaemorrhagic ventricular dilatationA Whitelaw
Division of Child Health, University of Bristol, Bristol, UK
Arch Dis Child Fetal Neonatal Ed 86:F72-4. 2002..It results initially from multiple small blood clots throughout the cerebrospinal fluid channels impeding circulation and reabsorption. Management is difficult and new treatment approaches are needed... - Phase 1 trial of prevention of hydrocephalus after intraventricular hemorrhage in newborn infants by drainage, irrigation, and fibrinolytic therapyAndrew Whitelaw
Division of Child Health, University of Bristol, Bristol, United Kingdom
Pediatrics 111:759-65. 2003..Treatment of posthemorrhagic ventricular dilation in premature infants is fraught with failures and complications. We have piloted a new treatment aimed at removing intraventricular blood and the cytokines associated with hydrocephalus... - Randomized clinical trial of prevention of hydrocephalus after intraventricular hemorrhage in preterm infants: brain-washing versus tapping fluidAndrew Whitelaw
Department of Clinical Science at North Bristol, University of Bristol, Bristol, United Kingdom
Pediatrics 119:e1071-8. 2007..The aim of this study was to test a new treatment intended to prevent hydrocephalus and shunt dependence after intraventricular hemorrhage... - Xenon enhances hypothermic neuroprotection in asphyxiated newborn pigsElavazhagan Chakkarapani
Department of Clinical Sciences at South Bristol, University of Bristol, Bristol, United Kingdom
Ann Neurol 68:330-41. 2010..To investigate whether inhaling 50% xenon during hypothermia (HT) offers better neuroprotection than xenon or HT alone... - Clinical trials of treatments after perinatal asphyxiaAndrew Whitelaw
Division of Child Health, University of Bristol, Bristol, United Kingdom
Curr Opin Pediatr 14:664-8. 2002..As time is critical with post-hypoxic interventions, the delay involved in obtaining informed parental consent for such trials might obscure a clinically important therapeutic effect... - Supportive care during neuroprotective hypothermia in the term newborn: adverse effects and their preventionMarianne Thoresen
Child Health, St Michael s Hospital, Level D, University of Bristol, Bristol, UK
Clin Perinatol 35:749-63, vii. 2008..The practical cooling recommendations suggested herein are therefore likely to develop and change over time as more experience is gained... - Neonatal rat model of intraventricular haemorrhage and post-haemorrhagic ventricular dilatation with long-term survival into adulthoodK Aquilina
School of Clinical Sciences, University of Bristol Department of Neurosurgery, Frenchay Hospital, Bristol, UK
Neuropathol Appl Neurobiol 37:156-65. 2011..Our objective is to evaluate survival, to adulthood, in our immature (7-day-old, P7) neonatal rat model, and to analyse early motor reflexes and fine motor and cognitive function, and neuropathology, at 8-12 weeks... - Serum gentamicin concentrations in encephalopathic infants are not affected by therapeutic hypothermiaXun Liu
Department of Child Health, St Michael s Hospital, University of Bristol, Bristol, United Kingdom
Pediatrics 124:310-5. 2009..We aimed to compare the SGCs in encephalopathic infants who underwent intensive care with therapeutic hypothermia or normothermia... - Delayed hypothermia as selective head cooling or whole body cooling does not protect brain or body in newborn pig subjected to hypoxia-ischemiaMathias Karlsson
Clinical Science at South Bristol Child Health, University of Bristol, Bristol, BS2 8EG, United Kingdom
Pediatr Res 64:74-8. 2008..Delayed HT improves postinsult recovery of plasma-calcium, magnesium, and potassium. There were no differences in adverse effects across groups... - A neonatal piglet model of intraventricular hemorrhage and posthemorrhagic ventricular dilationKristian Aquilina
Department of Child Health, University of Bristol, Clinical Sciences at South Bristol, United Kingdom
J Neurosurg 107:126-36. 2007..The authors have developed a neonatal large animal model of IVH with long-term survival, allowing the full development of PHVD... - Xenon/hypothermia neuroprotection regimes in spontaneously breathing neonatal rats after hypoxic-ischemic insult: the respiratory and sedative effectsJohn Dingley
Clinical Science at South Bristol, Child Health, University of Bristol, St Michael s Hospital, Bristol, UK
Anesth Analg 106:916-23, table of contents. 2008.... - Xenon and hypothermia combine additively, offering long-term functional and histopathologic neuroprotection after neonatal hypoxia/ischemiaCatherine Hobbs
Department of Clinical Sciences at South Bristol, University of Bristol, Bristol, UK
Stroke 39:1307-13. 2008..We investigated combinations of 50% xenon (Xe(50%)) and hypothermia of 32 degrees C (HT(32 degrees C)) as a post-HI therapy... - Transforming growth factor-betas in a rat model of neonatal posthaemorrhagic hydrocephalusS Cherian
Department of Clinical Science (South Bristol, University of Bristol, Bristol, UK
Neuropathol Appl Neurobiol 30:585-600. 2004.... - Do drugs that block transforming growth factor beta reduce posthaemorrhagic ventricular dilatation in a neonatal rat model?Kristian Aquilina
Department of Clinical Science at South Bristol, University of Bristol, Bristol, United Kingdom
Acta Paediatr 97:1181-6. 2008..They have excellent CSF and brain penetration. We hypothesized that administration of pirfenidone or losartan would reduce ventricular dilatation... - Head cooling with mild systemic hypothermia in anesthetized piglets is neuroprotectiveJames R Tooley
Department of Child Health, St. Michael's Hospital, University of Bristol, United Kingdom
Ann Neurol 53:65-72. 2003..We conclude that selective head cooling combined with mild systemic hypothermia and anesthesia is neuroprotective when started immediately after the insult in our piglet model of hypoxic-ischemic encephalopathy... - Posthemorrhagic ventricular dilation in the neonate: development and characterization of a rat modelShobha S Cherian
Division of Child Health, St. Michael's Hospital, Bristol, United Kingdom
J Neuropathol Exp Neurol 62:292-303. 2003..001). Body weights were not significantly different from controls. Hydrocephalic animals had reduced motor performance as assessed by a grip traction test (p = 0.0002). This model is well suited to studying the pathogenesis of PHVD... - Effects of hypothermia on energy metabolism in Mammalian central nervous systemMaria Erecinska
Department of Anatomy, University of Bristol, Bristol, United Kingdom
J Cereb Blood Flow Metab 23:513-30. 2003..Hypothermia may thus prove a promising avenue in the treatment of stroke and trauma and, in particular, of perinatal brain injury... - Significant selective head cooling can be maintained long-term after global hypoxia ischemia in newborn pigletsJames Tooley
Department of Child Health, St Michael's Hospital, University of Bristol, Bristol, United Kingdom
Pediatrics 109:643-9. 2002..However, we were unable to predict temperatures inside the brain using surface temperature probes on the head... - Development of amplitude-integrated electroencephalography and interburst interval in the ratAlexander M Tucker
Department of Child Health, University of Bristol, Bristol, BS2 8EG, United Kingdom
Pediatr Res 65:62-6. 2009..Based on aEEG trace analysis, the rat aEEG pattern at P1 corresponds to human aEEG at 23-wk gestation; P7 corresponds to 30-32 wk and P10 to 40-42 wk... - Cooling combined with immediate or delayed xenon inhalation provides equivalent long-term neuroprotection after neonatal hypoxia-ischemiaMarianne Thoresen
Department of Clinical Sciences at South Bristol, University of Bristol, Bristol, UK
J Cereb Blood Flow Metab 29:707-14. 2009..024). Females had significantly better motor scores than males, but no sex-dependent difference in pathology results. The neuroprotection of short, delayed Xe treatment would allow transport to specialist facilities to receive Xe... - A closed-circuit neonatal xenon delivery system: a technical and practical neuroprotection feasibility study in newborn pigsEla Chakkarapani
Department of Clinical Sciences at South Bristol, Universityof Bristol, Bristol, United Kingdom
Anesth Analg 109:451-60. 2009.... - Xenon provides short-term neuroprotection in neonatal rats when administered after hypoxia-ischemiaJohn Dingley
University of Wales Swansea, United Kingdom
Stroke 37:501-6. 2006..Because xenon does not cause other neurotoxic effects and has demonstrated minimal side effects in extensive anesthesia studies, it would make an ideal candidate for the treatment after human perinatal hypoxia-ischemia... - Hypothermia and perinatal asphyxia: executive summary of the National Institute of Child Health and Human Development workshopRosemary D Higgins
Pregnancy and Perinatology Branch, Center for Developmental Biology and Perinatal Medicine, National Institute of Child Health and Human Development/NIH, 6100 Executive Boulevard, MSC 7510, Bethesda, MD 20892, USA
J Pediatr 148:170-175. 2006 - Mild hypothermia and the distribution of cerebral lesions in neonates with hypoxic-ischemic encephalopathyMary A Rutherford
Imaging Sciences Department, Imperial College, Hammersmith Hospital, London, United Kingdom
Pediatrics 116:1001-6. 2005..This decrease was significant in infants with a moderate aEEG finding but not in those with a severe aEEG finding. A decrease in the incidence of severe cortical lesions was seen in the infants treated with SHC... - Hypothermia: an evolving treatment for neonatal hypoxic ischemic encephalopathyAlistair J Gunn
Pediatrics 121:648-9; author reply 649-50. 2008 - Therapeutic hypothermia in neonates. Review of current clinical data, ILCOR recommendations and suggestions for implementation in neonatal intensive care unitsThomas Hoehn
Neonatology and Pediatric Intensive Care Medicine, Department of General Pediatrics, Heinrich Heine University, Duesseldorf, Germany
Resuscitation 78:7-12. 2008.... - Determinants of outcomes after head cooling for neonatal encephalopathyJohn S Wyatt
Department of Paediatrics and Child Health, University College London, London, United Kingdom
Pediatrics 119:912-21. 2007..The goal of this study was to evaluate the role of factors that may determine the efficacy of treatment with delayed head cooling and mild systemic hypothermia for neonatal encephalopathy... - Therapeutic hypothermia changes the prognostic value of clinical evaluation of neonatal encephalopathyAlistair J Gunn
Department of Physiology, University of Auckland, Auckland, New Zealand
J Pediatr 152:55-8, 58.e1. 2008..To evaluate whether therapeutic hypothermia alters the prognostic value of clinical grading of neonatal encephalopathy... - Analysis of neuronal, glial, endothelial, axonal and apoptotic markers following moderate therapeutic hypothermia and anesthesia in the developing piglet brainPierre Gressens
INSERM, U676, Paris, France
Brain Pathol 18:10-20. 2008..Longer survival studies are necessary to verify the safety of hypothermia in the developing brain... - Non-protein-bound iron in brain interstitium of newborn pigs after hypoxiaKarin Savman
Department of Pediatrics, Perinatal Center, Goteborg University, The Queen Silvia Children s Hospital, Goteborg, Sweden
Dev Neurosci 27:176-84. 2005..97 (0.69) to 2.75 (1.85) micromol/l (not corrected for recovery rate) during early reoxygenation. NPBI may contribute to oxidative injury after perinatal hypoxic insults... - Selective head cooling with mild systemic hypothermia after neonatal encephalopathy: multicentre randomised trialPeter D Gluckman
The Liggins Institute, University of Auckland, Auckland, New Zealand
Lancet 365:663-70. 2005.... - Translational stroke research in the developing brainZinaida S Vexler
Department of Neurology, University of California San Francisco, San Francisco, California 94143 0663, USA
Pediatr Neurol 34:459-63. 2006..These issues need to be carefully addressed in designing future clinical trials...