N C Thomson

Summary

Affiliation: University of Glasgow
Country: UK

Publications

  1. ncbi request reprint Role of symptoms and lung function in determining asthma control in smokers with asthma
    R Chaudhuri
    Department of Respiratory Medicine, University of Glasgow, Glasgow, UK
    Allergy 63:132-5. 2008
  2. ncbi request reprint The role of environmental tobacco smoke in the origins and progression of asthma
    Neil C Thomson
    Department of Respiratory Medicine, Division of Immunology, Infection and Inflammation, Western Infirmary and University of Glasgow, Glasgow G11 6NT, UK
    Curr Allergy Asthma Rep 7:303-9. 2007
  3. ncbi request reprint Asthma and cigarette smoking
    N C Thomson
    Dept of Respiratory Medicine, Division of Immunology, Infection and Inflammation, Western Infirmary and University of Glasgow, Glasgow, G11 6NT, UK
    Eur Respir J 24:822-33. 2004
  4. ncbi request reprint The influence of smoking on the treatment response in patients with asthma
    Neil C Thomson
    Department of Respiratory Medicine, Division of Immunology, Infection and Inflammation, University of Glasgow, Glasgow, UK
    Curr Opin Allergy Clin Immunol 5:57-63. 2005
  5. pmc Identification and management of adults with asthma prone to exacerbations: can we do better?
    Neil C Thomson
    Respiratory Medicine Section, Division of Immunology, Infection and Inflammation, University of Glasgow, Glasgow, UK
    BMC Pulm Med 8:27. 2008
  6. doi request reprint Asthma in smokers: challenges and opportunities
    Neil C Thomson
    Division of Immunology, Infection and Inflammation, Department of Respiratory Medicine, University of Glasgow, Gartnavel General Hospital, Glasgow, UK
    Curr Opin Pulm Med 15:39-45. 2009
  7. ncbi request reprint Asthma therapy: theophylline
    N C Thomson
    University of Glasgow, Glasgow, United Kingdom
    Can Respir J 5:60A-3A. 1998
  8. doi request reprint Effects of atorvastatin added to inhaled corticosteroids on lung function and sputum cell counts in atopic asthma
    E J Hothersall
    Respiratory Medicine Section, Division of Immunology, Infection and Inflammation, University of Glasgow, Glasgow, UK
    Thorax 63:1070-5. 2008
  9. doi request reprint Effect of low-dose theophylline plus beclometasone on lung function in smokers with asthma: a pilot study
    M Spears
    Faculty of Medicine, University of Glasgow, Glasgow, UK
    Eur Respir J 33:1010-7. 2009
  10. doi request reprint Bronchodilatory effect of the PPAR-gamma agonist rosiglitazone in smokers with asthma
    M Spears
    Department of Respiratory Medicine, Faculty of Medicine, University of Glasgow, Glasgow, UK
    Clin Pharmacol Ther 86:49-53. 2009

Collaborators

Detail Information

Publications55

  1. ncbi request reprint Role of symptoms and lung function in determining asthma control in smokers with asthma
    R Chaudhuri
    Department of Respiratory Medicine, University of Glasgow, Glasgow, UK
    Allergy 63:132-5. 2008
    ..Cigarette smoking in asthma increases the severity and accelerates the decline in lung function. The relative role of symptoms and lung function in determining asthma control in smokers with asthma is not known...
  2. ncbi request reprint The role of environmental tobacco smoke in the origins and progression of asthma
    Neil C Thomson
    Department of Respiratory Medicine, Division of Immunology, Infection and Inflammation, Western Infirmary and University of Glasgow, Glasgow G11 6NT, UK
    Curr Allergy Asthma Rep 7:303-9. 2007
    ..Workplace smoking restrictions and reduced smoking in the home may lower the prevalence of asthma, improve asthma control, and reduce the use of medical services in both children and adults who are exposed to ETS...
  3. ncbi request reprint Asthma and cigarette smoking
    N C Thomson
    Dept of Respiratory Medicine, Division of Immunology, Infection and Inflammation, Western Infirmary and University of Glasgow, Glasgow, G11 6NT, UK
    Eur Respir J 24:822-33. 2004
    ..Alternative or additional therapies to inhaled corticosteroids are needed for asthmatic patients who are unable to quit smoking...
  4. ncbi request reprint The influence of smoking on the treatment response in patients with asthma
    Neil C Thomson
    Department of Respiratory Medicine, Division of Immunology, Infection and Inflammation, University of Glasgow, Glasgow, UK
    Curr Opin Allergy Clin Immunol 5:57-63. 2005
    ..We also consider the effect smoking has on other drugs commonly used to treat patients with asthma...
  5. pmc Identification and management of adults with asthma prone to exacerbations: can we do better?
    Neil C Thomson
    Respiratory Medicine Section, Division of Immunology, Infection and Inflammation, University of Glasgow, Glasgow, UK
    BMC Pulm Med 8:27. 2008
    ....
  6. doi request reprint Asthma in smokers: challenges and opportunities
    Neil C Thomson
    Division of Immunology, Infection and Inflammation, Department of Respiratory Medicine, University of Glasgow, Gartnavel General Hospital, Glasgow, UK
    Curr Opin Pulm Med 15:39-45. 2009
    ..We summarize recent evidence supporting the adverse effects of smoking in asthma and consider strategies to manage these patients...
  7. ncbi request reprint Asthma therapy: theophylline
    N C Thomson
    University of Glasgow, Glasgow, United Kingdom
    Can Respir J 5:60A-3A. 1998
    ..The relative efficacy and side effect profile of oral theophylline versus oral leukotriene modulators as an 'add on' therapy remain to be established...
  8. doi request reprint Effects of atorvastatin added to inhaled corticosteroids on lung function and sputum cell counts in atopic asthma
    E J Hothersall
    Respiratory Medicine Section, Division of Immunology, Infection and Inflammation, University of Glasgow, Glasgow, UK
    Thorax 63:1070-5. 2008
    ..A study was undertaken to test the hypothesis that atorvastatin added to inhaled corticosteroids improves lung function and airway inflammation in atopic adults with asthma...
  9. doi request reprint Effect of low-dose theophylline plus beclometasone on lung function in smokers with asthma: a pilot study
    M Spears
    Faculty of Medicine, University of Glasgow, Glasgow, UK
    Eur Respir J 33:1010-7. 2009
    ..Larger trials are required to extend and confirm these findings...
  10. doi request reprint Bronchodilatory effect of the PPAR-gamma agonist rosiglitazone in smokers with asthma
    M Spears
    Department of Respiratory Medicine, Faculty of Medicine, University of Glasgow, Glasgow, UK
    Clin Pharmacol Ther 86:49-53. 2009
    ..24 l/s, P = 0.030) as compared with inhaled beclometasone dipropionate. Further trials using PPAR-gamma agonists in steroid-resistant airway disease are indicated...
  11. ncbi request reprint Smoking and airway inflammation in patients with mild asthma
    G W Chalmers
    Department of Respiratory Medicine, Western Infirmary, Glasgow, UK
    Chest 120:1917-22. 2001
    ....
  12. ncbi request reprint Systemic sensitivity to corticosteroids in smokers with asthma
    E Livingston
    Department of Respiratory Medicine, Division of Immunology, Infection and Inflammation, University of Glasgow and Western Infirmary, Glasgow, G11 6NT, UK
    Eur Respir J 29:64-71. 2007
    ..This finding suggests that the insensitivity to corticosteroids in smokers with asthma affects tissue sites other than the airways...
  13. ncbi request reprint Immuno-regulatory cytokines in asthma: IL-15 and IL-13 in induced sputum
    M Komai-Koma
    Department of Immunology, Western Infirmary, Glasgow, UK
    Clin Exp Allergy 31:1441-8. 2001
    ..The macrophage-derived cytokine, interleukin (IL)-15 has a number of T cell regulatory properties which might be of relevance to asthma and its treatment...
  14. ncbi request reprint Serum and sputum neurotrophin levels in chronic persistent cough
    R Chaudhuri
    Departments of Respiratory Medicine, University of Glasgow and Western Infirmary, Glasgow, UK
    Clin Exp Allergy 35:949-53. 2005
    ..Neurogenic inflammation is implicated in the pathogenesis of chronic cough in individuals with normal chest radiography, but the role of NTs in this condition is unknown...
  15. doi request reprint Peripheral blood dendritic cell subtypes are significantly elevated in subjects with asthma
    M Spears
    Department of Respiratory Medicine, Institute of Infection, Immunity and Inflammation, Gartnavel General Hospital, University of Glasgow, Glasgow, UK
    Clin Exp Allergy 41:665-72. 2011
    ..Smokers with asthma display altered therapeutic behaviour and a reduction in endobronchial DC CD83 expression compared with non-smokers with asthma. No information is available on the impact of smoking on peripheral blood DC profiles...
  16. pmc High resolution computed tomographic assessment of airway wall thickness in chronic asthma: reproducibility and relationship with lung function and severity
    S A Little
    Department of Respiratory Medicine, Western Infirmary, Glasgow, UK
    Thorax 57:247-53. 2002
    ....
  17. pmc Efficacy of low and high dose inhaled corticosteroid in smokers versus non-smokers with mild asthma
    J E M Tomlinson
    Department of General Practice, University of Glasgow, Glasgow, UK
    Thorax 60:282-7. 2005
    ..Cigarette smokers with asthma are insensitive to short term inhaled corticosteroid therapy, but efficacy when given for a longer duration at different doses is unknown...
  18. ncbi request reprint Effect of improved home ventilation on asthma control and house dust mite allergen levels
    G R Wright
    Department of Respiratory Medicine, Division of Immunology, Infection and Inflammation, University of Glasgow, Glasgow, UK
    Allergy 64:1671-80. 2009
    ..We tested the hypothesis that a domestic mechanical heat recovery ventilation system (MHRV), in addition to allergen avoidance measures, can improve asthma control by attenuating re-colonization rates...
  19. ncbi request reprint The effect of acute alteration in oxygen tension on the bronchodilator response to salbutamol in vitro and in vivo in man
    K D Dagg
    Department of Respiratory Medicine, North Glasgow Hospitals University NHS Trust, Glasgow, G12 0YN, UK
    Pulm Pharmacol Ther 14:99-105. 2001
    ..We conclude that acute hypoxia attenuates airway smooth muscle relaxation in response to salbutamol in vitro but has no effect on salbutamol-induced bronchodilation in in-patients with asthma...
  20. ncbi request reprint Effect of infused angiotensin II on the bronchoconstrictor activity of inhaled endothelin-1 in asthma
    G W Chalmers
    Department of Respiratory Medicine, West Glasgow Hospitals University NHS Trust, Scotland, UK
    Chest 115:352-6. 1999
    ..We wished to examine any potentiation of the bronchoconstrictor activity of inhaled ET-1 by infused Ang II at subbronchoconstrictor doses...
  21. ncbi request reprint No effect of the oral neutral endopeptidase inhibitor candoxatril, on bronchomotor tone and histamine reactivity in asthma
    R M Angus
    Dept of Respiratory Medicine, Western Infirmary, Glasgow, UK
    Eur Respir J 7:1084-9. 1994
    ..17 (0.25-25.8) and 0.93 (0.13-32) mg.ml-1, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)..
  22. ncbi request reprint Interleukin-18 levels in induced sputum are reduced in asthmatic and normal smokers
    A McKay
    Division of Immunology, Infection and Inflammation, University of Glasgow, Glasgow, UK
    Clin Exp Allergy 34:904-10. 2004
    ..As such, it may have a regulatory role in asthma by modifying Th2 lymphocyte responses. Cigarette smoking may amplify the airway inflammation associated with asthma...
  23. doi request reprint Long-term macrolide treatment of chronic inflammatory airway diseases: risks, benefits and future developments
    E J Cameron
    Respiratory Medicine, Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, UK
    Clin Exp Allergy 42:1302-12. 2012
    ..Potentially novel macrolides may overcome a significant barrier to the use of this type of drug for the long-term treatment of chronic inflammatory airway diseases...
  24. pmc Influence of cigarette smoking on inhaled corticosteroid treatment in mild asthma
    G W Chalmers
    Departments of Respiratory Medicine and Immunology, Western Infirmary, Glasgow G11 6NT, UK
    Thorax 57:226-30. 2002
    ..A study was undertaken to investigate the effect of active cigarette smoking on responses to treatment with inhaled corticosteroids in patients with mild asthma...
  25. ncbi request reprint Peroxisome proliferator-activated receptor-gamma agonists as potential anti-inflammatory agents in asthma and chronic obstructive pulmonary disease
    M Spears
    Department of Respiratory Medicine, Division of Immunology, Infection and Inflammation, University of Glasgow, Glasgow, UK
    Clin Exp Allergy 36:1494-504. 2006
    ..We review the evidence from these experimental models and their applicability to asthma and COPD and the requirements for future clinical and experimental research...
  26. ncbi request reprint Effects of smoking cessation on lung function and airway inflammation in smokers with asthma
    Rekha Chaudhuri
    FRCP, Department of Respiratory Medicine, Division of Immunology, Infection and Inflammation, University of Glasgow and Western Infirmary, Glasgow G11 6NT, UK
    Am J Respir Crit Care Med 174:127-33. 2006
    ..Active smoking in asthma is associated with worsening of symptoms, accelerated decline in lung function, and impaired response to corticosteroids...
  27. pmc Interleukin-33 amplifies IgE synthesis and triggers mast cell degranulation via interleukin-4 in naïve mice
    M Komai-Koma
    Institute of Infection, Immunity and Inflammation, University of Glasgow, UK
    Allergy 67:1118-26. 2012
    ..IL-33 administration increases serum IgE in mice with unknown mechanism. We tested the hypothesis that IL-33 provides an antigen-independent stimulus for IgE production and mast cell degranulation...
  28. ncbi request reprint Sputum endothelin-1 is increased in cystic fibrosis and chronic obstructive pulmonary disease
    G W Chalmers
    Dept of Respiratory Medicine, West Glasgow Hospitals University NHS Trust, UK
    Eur Respir J 13:1288-92. 1999
    ..The role of endothelin-1 in contributing to airflow obstruction through bronchoconstriction and mitogenesis in cystic fibrosis needs now to be explored...
  29. ncbi request reprint Short and long-term effects of cigarette smoking independently influence exhaled nitric oxide concentration in asthma
    Charles P McSharry
    Department of Immunology, Division of Immunology, Infection and Inflammation, University of Glasgow, United Kingdom
    J Allergy Clin Immunol 116:88-93. 2005
    ..The fractional concentration of nitric oxide in exhaled breath (FeNO) is elevated in asthma. FeNO measurement has been proposed as a noninvasive index of disease activity. Cigarette smoking suppresses FeNO, which limits its use in smokers...
  30. ncbi request reprint Challenges of treating asthma in people who smoke
    Mark Spears
    Respiratory Medicine Section, Division of Immunology, Infection and Inflammation, Gartnavel General Hospital and University of Glasgow, Glasgow G12 OYN, UK
    Expert Rev Clin Immunol 6:257-68. 2010
    ..This review examines the range of adverse health effects of smoking in asthma, the inflammatory mechanisms that may influence the efficacy of current drugs and discusses potential future therapeutic directions...
  31. ncbi request reprint Nerve growth factor in serum and lymphocyte culture in pigeon fanciers' acute hypersensitivity pneumonitis
    Charles P McSharry
    Department of Immunology, Division of Immunology, Infection and Inflammation, University of Glasgow, UK
    Chest 130:37-42. 2006
    ..Nerve growth factor (NGF) is a neurotrophic cytokine with immunomodulatory activity. NGF contributes to neurogenic inflammation and has been described in asthma and idiopathic pulmonary fibrosis...
  32. ncbi request reprint Arachidonic acid metabolites and enzyme transcripts in asthma are altered by cigarette smoking
    N C Thomson
    Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, UK
    Allergy 69:527-36. 2014
    ..The aim of the study was to examine the effect of smoking status on urinary, sputum, and plasma eicosanoid concentrations and relevant enzyme transcripts in asthma...
  33. ncbi request reprint Effects of a FLAP inhibitor, GSK2190915, in asthmatics with high sputum neutrophils
    R Chaudhuri
    Institute of Infection, Immunity and Inflammation, University of Glasgow and Respiratory Medicine, Gartnavel General Hospital, Glasgow, UK Electronic address
    Pulm Pharmacol Ther 27:62-9. 2014
    ..There were no safety issues. Despite suppressing the target mediator LTB4, FLAP inhibitor GSK2190915 had no short-term effect on sputum cell counts or clinical endpoints in patients with asthma and sputum neutrophilia...
  34. doi request reprint Treating patients with respiratory disease who smoke
    Georgina Braganza
    Department of Respiratory Medicine, Division of Immunology, Infection and Inflammation, University of Glasgow, Glasgow, UK
    Ther Adv Respir Dis 2:95-107. 2008
    ....
  35. doi request reprint Assessment of the presence of occult myocardial infarction in chronic obstructive pulmonary disease using contrast-enhanced cardiac magnetic resonance imaging
    C Aengus Murphy
    Cardiology Department, Western Infirmary, University of Glasgow, Glasgow, UK
    Respiration 78:263-9. 2009
    ..Chronic obstructive pulmonary disease (COPD) has been identified as a risk factor for ischaemic heart disease, independent of smoking history, and inflammation is thought to play a role...
  36. ncbi request reprint Association of forced expiratory volume with disease duration and sputum neutrophils in chronic asthma
    Stuart A Little
    Department of Respiratory Medicine, University of Glasgow, Glasgow, Scotland, United Kingdom
    Am J Med 112:446-52. 2002
    ..The negative associations of sputum neutrophil count and activation with maximal FEV(1) suggest that neutrophils may be involved in the pathophysiology of irreversible airflow obstruction in asthma...
  37. ncbi request reprint Effects of angiotensin II on remodelling of the airway and the vasculature in the rat
    S G Ramsay
    Department of Respiratory Medicine, West Glasgow Hospitals University NHS Trust, Glasgow, Scotland, U K
    Clin Sci (Lond) 98:1-7. 2000
    ..Therefore a 2-week infusion of angiotensin II increases blood pressure and DNA synthesis in the mesenteric arteries, but does not cause airway remodelling, in the rat...
  38. pmc Potential therapeutic role for statins in respiratory disease
    E Hothersall
    Department of Respiratory Medicine, Division of Immunology, Infection and Inflammation, Western Infirmary and University of Glasgow, Glasgow G11 6NT, UK
    Thorax 61:729-34. 2006
    ..This review considers the evidence for the anti-inflammatory properties of statins in the lung, and how these effects are being applied to research into the role of statins as a novel treatment of respiratory diseases...
  39. ncbi request reprint In vivo and in vitro human airway responsiveness to leukotriene D4 in patients without asthma
    J A Roberts
    Department of Respiratory Medicine, Western Infirmary, Glasgow, Scotland
    J Allergy Clin Immunol 80:688-94. 1987
    ....
  40. ncbi request reprint Impact of smoking on asthma therapy: a critical review of clinical evidence
    Eric Livingston
    Department of Respiratory Medicine, Division of Immunology, Infection and Inflammation, University of Glasgow, Glasgow, UK
    Drugs 65:1521-36. 2005
    ..Smoking cessation measures must be given a high priority in individuals with asthma who smoke...
  41. ncbi request reprint Asthma: ten myths debunked
    Gillian Vallance
    Department of Respiratory Medicine, Division of Immunology, Infection and Inflammation, University of Glasgow
    Practitioner 248:844-7. 2004
  42. ncbi request reprint Cigarette smoking impairs the therapeutic response to oral corticosteroids in chronic asthma
    Rekha Chaudhuri
    Department of Respiratory Medicine, University of Glasgow, Glasgow, UK
    Am J Respir Crit Care Med 168:1308-11. 2003
    ..1; CI, 2.3, 56; p = 0.04 and 52.4; CI, 26, 79; p = 0.003, respectively), but not in FEV1 or asthma control score. We conclude that active smoking impairs the efficacy of short-term oral corticosteroid treatment in chronic asthma...
  43. ncbi request reprint Managing chronic obstructive pulmonary disease
    Eric Livingston
    Department of Respiratory Medicine, University of Glasgow, Western Infirmary, Glasgow
    Practitioner 247:289, 292, 296 passim. 2003
  44. ncbi request reprint Antiinflammatory effects of salmeterol/fluticasone propionate in chronic obstructive lung disease
    Neil C Barnes
    Department of Respiratory Medicine, London Chest Hospital, London, UK
    Am J Respir Crit Care Med 173:736-43. 2006
    ..No currently available treatment is reported to reduce the exaggerated airway wall inflammation of chronic obstructive pulmonary disease...
  45. ncbi request reprint Effect of inhaled corticosteroids on symptom severity and sputum mediator levels in chronic persistent cough
    Rekha Chaudhuri
    Department of Respiratory Medicine, Division of Immunology, Infection and Inflammation, University of Glasgow and Western Infirmary, Glasgow G11 6NT, Scotland, United Kingdom
    J Allergy Clin Immunol 113:1063-70. 2004
    ..Chronic cough often lasts for more than 1 year and is associated with airway inflammation. The effect of inhaled corticosteroids on symptom severity and inflammatory mediator levels in these patients is unknown...
  46. ncbi request reprint Glucocorticoid-induced TNFR family-related protein (GITR) activation exacerbates murine asthma and collagen-induced arthritis
    Manish Patel
    Division of Immunology, Infection and Inflammation, University of Glasgow, Glasgow, UK
    Eur J Immunol 35:3581-90. 2005
    ..Our results therefore provide direct evidence that GITR can modulate both Th1- and Th2-mediated inflammatory diseases, and may be a potential target for therapeutic intervention...
  47. ncbi request reprint A novel anti-inflammatory role of simvastatin in a murine model of allergic asthma
    Anne McKay
    Division of Immunology, Infection, and Inflammation, Section of Respiratory Medicine, University of Glasgow, Glasgow, United Kingdom
    J Immunol 172:2903-8. 2004
    ..Simvastatin treatment did not alter serum total IgE or OVA-specific IgG1 and IgG2a levels. These data demonstrate the therapeutic potential of statin-sensitive pathways in allergic airways disease...
  48. pmc Stepping down inhaled corticosteroids in asthma: randomised controlled trial
    Gillian Hawkins
    Department of General Practice, University of Glasgow, Glasgow G12 0RR
    BMJ 326:1115. 2003
    ..To determine whether the dose of inhaled corticosteroids can be stepped down in patients with chronic stable asthma while maintaining control...
  49. ncbi request reprint Budesonide and formoterol in a single inhaler improves asthma control compared with increasing the dose of corticosteroid in adults with mild-to-moderate asthma
    Umesh G Lalloo
    Nelson R Mandela School of Medicine, University of Natal, Durban, South Africa
    Chest 123:1480-7. 2003
    ....
  50. ncbi request reprint Why is eosinophilic bronchitis not asthma?
    Neil C Thomson
    Am J Respir Crit Care Med 170:4-5. 2004
  51. ncbi request reprint Glucocorticoid receptor alpha:beta ratio in blood mononuclear cells is reduced in cigarette smokers
    Eric Livingston
    J Allergy Clin Immunol 114:1475-8. 2004
  52. ncbi request reprint Asthma control during the year after bronchial thermoplasty
    Gerard Cox
    St Joseph s Healthcare, McMaster University, Hamilton, ON, Canada
    N Engl J Med 356:1327-37. 2007
    ..Bronchial thermoplasty is a bronchoscopic procedure to reduce the mass of airway smooth muscle and attenuate bronchoconstriction. We examined the effect of bronchial thermoplasty on the control of moderate or severe persistent asthma...
  53. ncbi request reprint Safety and efficacy of bronchial thermoplasty in symptomatic, severe asthma
    Ian D Pavord
    Glenfield General Hospital, University Hospitals of Leicester NHS Trust, Groby Road, Leicester LE3 9QP, United Kingdom
    Am J Respir Crit Care Med 176:1185-91. 2007
    ..Bronchial thermoplasty (BT) is designed to reduce airway smooth muscle and improve asthma control...
  54. ncbi request reprint Smokers with asthma: what are the management options?
    Neil C Thomson
    Am J Respir Crit Care Med 175:749-50. 2007