S G Thompson

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. ncbi request reprint Bayesian methods for analysis of binary outcome data in cluster randomized trials on the absolute risk scale
    Simon G Thompson
    MRC Biostatistics Unit, Institute of Public Health, Robinson Way, Cambridge CB2 2SR, U K
    Stat Med 23:389-410. 2004
  2. pmc Dietary energy density and adiposity: employing bias adjustments in a meta-analysis of prospective studies
    Desiree C Wilks
    Medical Research Council Human Nutrition Research, Cambridge, UK
    BMC Public Health 11:48. 2011
  3. pmc The DYD-RCT protocol: an on-line randomised controlled trial of an interactive computer-based intervention compared with a standard information website to reduce alcohol consumption among hazardous drinkers
    Elizabeth Murray
    e Health Unit, Department of Primary Care and Population Sciences, University College London, Highgate Hill, London N19 5LW, UK
    BMC Public Health 7:306. 2007
  4. pmc Design and performance of a multi-centre randomised controlled trial and economic evaluation of joint tele-consultations [ISRCTN54264250]
    Paul Wallace
    Department of Primary Care and Population Sciences, Royal Free and University College Medical School, Rowland Hill Street, London NW3 2PF, UK
    BMC Fam Pract 3:1. 2002
  5. pmc Screening men for abdominal aortic aneurysm: 10 year mortality and cost effectiveness results from the randomised Multicentre Aneurysm Screening Study
    S G Thompson
    MRC Biostatistics Unit, Institute of Public Health, Cambridge CB2 0SR
    BMJ 338:b2307. 2009
  6. ncbi request reprint Treating individuals 4: can meta-analysis help target interventions at individuals most likely to benefit?
    Simon G Thompson
    MRC Biostatistics Unit, Institute of Public Health, Cambridge CB2 2 sR, UK
    Lancet 365:341-6. 2005
  7. ncbi request reprint Trial designs for targeted therapies
    Simon G Thompson
    MRC Biostatistics Unit, Institute of Public Health, Robinson Way, Cambridge CB2 2SR, UK
    Biom J 48:908-10; discussion 914-5. 2006
  8. ncbi request reprint Addressing the issues that arise in analysing multicentre cost data, with application to a multinational study
    Simon G Thompson
    MRC Biostatistics Unit, Institute of Public Health, Cambridge, UK
    J Health Econ 25:1015-28. 2006
  9. ncbi request reprint How sensitive are cost-effectiveness analyses to choice of parametric distributions?
    Simon G Thompson
    MRC Biostatistics Unit, Institute of Public Health, Cambridge, UK
    Med Decis Making 25:416-23. 2005
  10. pmc Statistical methods for the time-to-event analysis of individual participant data from multiple epidemiological studies
    Simon Thompson
    MRC Biostatistics Unit, Institute of Public Health, Cambridge, UK
    Int J Epidemiol 39:1345-59. 2010

Collaborators

Detail Information

Publications65

  1. ncbi request reprint Bayesian methods for analysis of binary outcome data in cluster randomized trials on the absolute risk scale
    Simon G Thompson
    MRC Biostatistics Unit, Institute of Public Health, Robinson Way, Cambridge CB2 2SR, U K
    Stat Med 23:389-410. 2004
    ..Using these methods, we can benefit from the advantages of Bayesian modelling of binary outcome data at the same time as providing results on a clinically interpretable scale...
  2. pmc Dietary energy density and adiposity: employing bias adjustments in a meta-analysis of prospective studies
    Desiree C Wilks
    Medical Research Council Human Nutrition Research, Cambridge, UK
    BMC Public Health 11:48. 2011
    ....
  3. pmc The DYD-RCT protocol: an on-line randomised controlled trial of an interactive computer-based intervention compared with a standard information website to reduce alcohol consumption among hazardous drinkers
    Elizabeth Murray
    e Health Unit, Department of Primary Care and Population Sciences, University College London, Highgate Hill, London N19 5LW, UK
    BMC Public Health 7:306. 2007
    ..Researchers internationally are looking at the potential of Internet interventions in this area...
  4. pmc Design and performance of a multi-centre randomised controlled trial and economic evaluation of joint tele-consultations [ISRCTN54264250]
    Paul Wallace
    Department of Primary Care and Population Sciences, Royal Free and University College Medical School, Rowland Hill Street, London NW3 2PF, UK
    BMC Fam Pract 3:1. 2002
    ....
  5. pmc Screening men for abdominal aortic aneurysm: 10 year mortality and cost effectiveness results from the randomised Multicentre Aneurysm Screening Study
    S G Thompson
    MRC Biostatistics Unit, Institute of Public Health, Cambridge CB2 0SR
    BMJ 338:b2307. 2009
    ..To assess whether the mortality benefit from screening men aged 65-74 for abdominal aortic aneurysm decreases over time, and to estimate the long term cost effectiveness of screening...
  6. ncbi request reprint Treating individuals 4: can meta-analysis help target interventions at individuals most likely to benefit?
    Simon G Thompson
    MRC Biostatistics Unit, Institute of Public Health, Cambridge CB2 2 sR, UK
    Lancet 365:341-6. 2005
    ..Also, although meta-analyses generally summarise an intervention's effect as a relative risk reduction, the groups of patients with the greatest absolute risk reduction have the most to gain...
  7. ncbi request reprint Trial designs for targeted therapies
    Simon G Thompson
    MRC Biostatistics Unit, Institute of Public Health, Robinson Way, Cambridge CB2 2SR, UK
    Biom J 48:908-10; discussion 914-5. 2006
    ..This is a discussion of the paper 'Making efficient use of patients in designing phase III trials investigating simultaneously a set of targeted therapies with different targets' by Werner Vach and Rene dePont Christensen...
  8. ncbi request reprint Addressing the issues that arise in analysing multicentre cost data, with application to a multinational study
    Simon G Thompson
    MRC Biostatistics Unit, Institute of Public Health, Cambridge, UK
    J Health Econ 25:1015-28. 2006
    ..Analysis of multinational cost data must recognise differences in mean, spread and skewness across centres, as well as the data's hierarchical structure...
  9. ncbi request reprint How sensitive are cost-effectiveness analyses to choice of parametric distributions?
    Simon G Thompson
    MRC Biostatistics Unit, Institute of Public Health, Cambridge, UK
    Med Decis Making 25:416-23. 2005
    ..Cost data usually have very skewed distributions and can be difficult to model. The authors investigate whether choice of distribution can make a difference to the conclusions drawn...
  10. pmc Statistical methods for the time-to-event analysis of individual participant data from multiple epidemiological studies
    Simon Thompson
    MRC Biostatistics Unit, Institute of Public Health, Cambridge, UK
    Int J Epidemiol 39:1345-59. 2010
    ..Meta-analysis of individual participant time-to-event data from multiple prospective epidemiological studies enables detailed investigation of exposure-risk relationships, but involves a number of analytical challenges...
  11. pmc A proposed method of bias adjustment for meta-analyses of published observational studies
    Simon Thompson
    MRC Biostatistics Unit, Cambridge, UK
    Int J Epidemiol 40:765-77. 2011
    ....
  12. ncbi request reprint How should meta-regression analyses be undertaken and interpreted?
    Simon G Thompson
    MRC Biostatistics Unit, Institute of Public Health, Robinson Way, Cambridge CB2 2SR, UK
    Stat Med 21:1559-73. 2002
    ..The examples considered in this paper show the tension between the scientific rationale for using meta-regression and the difficult interpretative problems to which such analyses are prone...
  13. ncbi request reprint Systematic review and meta-analysis of the growth and rupture rates of small abdominal aortic aneurysms: implications for surveillance intervals and their cost-effectiveness
    S G Thompson
    Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
    Health Technol Assess 17:1-118. 2013
    ..5 cm) at which surgical intervention is considered. The choice of appropriate surveillance intervals is governed by the growth and rupture rates of small AAAs, as well as their relative cost-effectiveness...
  14. ncbi request reprint Multilevel models for meta-analysis, and their application to absolute risk differences
    S G Thompson
    MRC Biostatistics Unit, Institute of Public Health, Robinson Way, Cambridge, CB2 2SR, UK
    Stat Methods Med Res 10:375-92. 2001
    ..We show how this can be achieved within a Bayesian analysis, while still recognizing the binary nature of the original outcome data...
  15. ncbi request reprint Implications of screening for abdominal aortic aneurysms on surgical workload
    L G Kim
    Medical Research Council Biostatistics Unit, Cambridge, UK
    Br J Surg 92:171-6. 2005
    ..If a national screening programme for AAA were adopted in the UK, it would be expected to increase the elective and decrease the emergency surgical workload...
  16. ncbi request reprint Late results concerning feasibility and compliance from a randomized trial of ultrasonographic screening for abdominal aortic aneurysm
    K A Vardulaki
    Medical Research Council Biostatistics Unit, Institute of Public Health and Strangeways Research Laboratory, Cambridge, UK
    Br J Surg 89:861-4. 2002
    ..The extent of benefit, feasibility and compliance were examined, and reasons why this intervention may fail a proportion of those screened were identified...
  17. ncbi request reprint How cost-effective is screening for abdominal aortic aneurysms?
    L G Kim
    MRC Biostatistics Unit, Institute of Public Health, Robinson Way, Cambridge CB2 2SR, UK
    J Med Screen 14:46-52. 2007
    ..To provide reliable estimates of the long-term cost-effectiveness of abdominal aortic aneurysm screening in men...
  18. ncbi request reprint Parametric modelling of cost data in medical studies
    R M Nixon
    Biostatistics Unit, University Forvie Site MRC, Robinson Way, Cambridge CB2 2SR, U K
    Stat Med 23:1311-31. 2004
    ..Investigating the sensitivity of conclusions to choice of model should thus be an essential component of analysing cost data in practice...
  19. ncbi request reprint Bayesian random effects meta-analysis of trials with binary outcomes: methods for the absolute risk difference and relative risk scales
    D E Warn
    MRC Biostatistics Unit, Institute of Public Health, University Forvie Site, Robinson Way, Cambridge, CB2 2SR, UK
    Stat Med 21:1601-23. 2002
    ..The advantages and flexibility of a fully Bayesian approach to meta-analysis of binary outcome data, considered on an absolute risk or relative risk scale, are now available...
  20. ncbi request reprint Meta-analysis of continuous outcome data from individual patients
    J P Higgins
    MRC Biostatistics Unit, Institute of Public Health, University Forvie Site, Robinson Way, Cambridge CB2 2SR, U K
    Stat Med 20:2219-41. 2001
    ..Relative merits of the three software packages for such meta-analyses are discussed, as are the assessment of model assumptions and extensions to incorporate more than two treatments...
  21. pmc Separate and combined associations of body-mass index and abdominal adiposity with cardiovascular disease: collaborative analysis of 58 prospective studies
    David Wormser
    Emerging Risk Factors Collaboration Coordinating Centre, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge CB1 8RN, UK
    Lancet 377:1085-95. 2011
    ..We studied the separate and combined associations of body-mass index (BMI), waist circumference, and waist-to-hip ratio with risk of first-onset cardiovascular disease...
  22. pmc Triglyceride-mediated pathways and coronary disease: collaborative analysis of 101 studies
    Nadeem Sarwar
    Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Wort s Causeway, Cambridge CB1 8RN, UK
    Lancet 375:1634-9. 2010
    ..Whether triglyceride-mediated pathways are causally relevant to coronary heart disease is uncertain. We studied a genetic variant that regulates triglyceride concentration to help judge likelihood of causality...
  23. ncbi request reprint Prior distributions for the intracluster correlation coefficient, based on multiple previous estimates, and their application in cluster randomized trials
    Rebecca M Turner
    MRC Biostatistics Unit, Institute of Public Health, Cambridge, UK
    Clin Trials 2:108-18. 2005
    ..The methods proposed enable available ICC information to be summarised appropriately by an informative prior distribution, which is of direct practical use in cluster randomized trials...
  24. ncbi request reprint Modelling multivariate outcomes in hierarchical data, with application to cluster randomised trials
    Rebecca M Turner
    MRC Biostatistics Unit, Institute of Public Health, Robinson Way, Cambridge CB2 2SR, UK
    Biom J 48:333-45. 2006
    ..The methods are applied to an example of a cluster randomised trial in the prevention of coronary heart disease. The modelling strategy presented would also be useful in other situations involving hierarchical multivariate outcomes...
  25. ncbi request reprint Controlling the risk of spurious findings from meta-regression
    Julian P T Higgins
    MRC Biostatistics Unit, Institute of Public Health, Robinson Way, Cambridge CB2 2SR, U K
    Stat Med 23:1663-82. 2004
    ..The permutation test appropriately tempers the statistical significance of meta-regression findings. We recommend its use before a statistically significant relationship is claimed from a standard meta-regression analysis...
  26. ncbi request reprint Constructing intervals for the intracluster correlation coefficient using Bayesian modelling, and application in cluster randomized trials
    Rebecca M Turner
    MRC Biostatistics Unit, Institute of Public Health, Robinson Way, Cambridge, CB2 2SR, UK
    Stat Med 25:1443-56. 2006
    ..There is also the opportunity to incorporate prior beliefs on likely values of the ICC. The methods are exemplified using data from a cluster randomized trial...
  27. ncbi request reprint A sustained mortality benefit from screening for abdominal aortic aneurysm
    Lois G Kim
    Institute of Public Health, Cambridge, United Kingdom, and St Richard s Hospital, Chichester, United Kingdom
    Ann Intern Med 146:699-706. 2007
    ..Longer-term mortality benefit and cost-effectiveness for abdominal aortic aneurysm (AAA) screening are uncertain...
  28. ncbi request reprint A modelling strategy for the analysis of clinical trials with partly missing longitudinal data
    Ian R White
    MRC Biostatistics Unit, Institute of Public Health, Cambridge, UK
    Int J Methods Psychiatr Res 12:139-50. 2003
    ..All models give similar estimates of the intervention effect and we conclude that non-response bias is likely to be small...
  29. ncbi request reprint Allowing for imprecision of the intracluster correlation coefficient in the design of cluster randomized trials
    Rebecca M Turner
    MRC Biostatistics Unit, Institute of Public Health, Robinson Way, Cambridge CB2 2SR, U K
    Stat Med 23:1195-214. 2004
    ..The methods presented in this paper can be used by applied researchers to protect against loss of power, or to choose a design which reduces the impact of uncertainty in the ICC...
  30. ncbi request reprint Modelling multiple sources of dissemination bias in meta-analysis
    Jack Bowden
    MRC Biostatistics Unit, Institute of Public Health, Robinson Way, Cambridge CB2 0SR, U K
    Stat Med 29:945-55. 2010
    ..In practical applications, the methods can be used to provide sensitivity analyses for the potential effects of multiple dissemination biases operating in meta-analysis...
  31. ncbi request reprint Extending DerSimonian and Laird's methodology to perform multivariate random effects meta-analyses
    Dan Jackson
    MRC Biostatistics Unit, Institute of Public Health, Robinson Way, Cambridge CB2 0SR, UK
    Stat Med 29:1282-97. 2010
    ..The method is applied to some real data sets and an extension to multivariate meta-regression is described...
  32. pmc Measuring inconsistency in meta-analyses
    Julian P T Higgins
    MRC Biostatistics Unit, Institute of Public Health, Cambridge CB2 2SR
    BMJ 327:557-60. 2003
  33. ncbi request reprint Are missing outcome data adequately handled? A review of published randomized controlled trials in major medical journals
    Angela M Wood
    MRC Biostatistics Unit, Institute of Public Health, Cambridge, UK
    Clin Trials 1:368-76. 2004
    ..We examine how missing outcome data are handled in randomized controlled trials in order to assess whether adequate steps have been taken to reduce nonresponse bias and to identify ways to improve procedures for missing data...
  34. ncbi request reprint The use of random effects models to allow for clustering in individually randomized trials
    Katherine J Lee
    MRC Biostatistics Unit, Institute of Public Health, Cambridge, UK
    Clin Trials 2:163-73. 2005
    ..We propose random effects models to allow for such clustering, across a range of contexts and trial designs, and investigate their effect on estimation and interpretation of the treatment effect...
  35. ncbi request reprint Quantifying heterogeneity in a meta-analysis
    Julian P T Higgins
    MRC Biostatistics Unit, Institute of Public Health, Robinson Way, Cambridge CB2 2SR, UK
    Stat Med 21:1539-58. 2002
    ..One or both should be presented in published meta-analyses in preference to the test for heterogeneity...
  36. pmc Clustering by health professional in individually randomised trials
    Katherine J Lee
    MRC Biostatistics Unit, Institute of Public Health, Cambridge CB2 2SR
    BMJ 330:142-4. 2005
  37. ncbi request reprint Adjusting for partially missing baseline measurements in randomized trials
    Ian R White
    MRC Biostatistics Unit, Institute of Public Health, Robinson Way, Cambridge CB2 2SR, U K
    Stat Med 24:993-1007. 2005
    ..The methods are illustrated in a randomized trial in community psychiatry...
  38. ncbi request reprint Choice of test for comparing two groups, with particular application to skewed outcomes
    Ian R White
    MRC Biostatistics Unit, Institute of Public Health, Robinson Way, Cambridge CB2 2SR, UK
    Stat Med 22:1205-15. 2003
    ..We show that a comparison of sample means is a reasonable choice in this case despite the skewness...
  39. ncbi request reprint Methods for incorporating covariate adjustment, subgroup analysis and between-centre differences into cost-effectiveness evaluations
    Richard M Nixon
    MRC Biostatistics Unit, Institute of Public Health, Robinson Way, Cambridge, UK
    Health Econ 14:1217-29. 2005
    ..It is often important, however, also to investigate how cost-effectiveness varies between patient subgroups. Yet such analyses are rarely undertaken, because appropriate methods have not been sufficiently developed...
  40. ncbi request reprint Plasma fibrinogen level and the risk of major cardiovascular diseases and nonvascular mortality: an individual participant meta-analysis
    John Danesh
    Department of Public Health and Primary Care, University of Cambridge, Cambridge, England
    JAMA 294:1799-809. 2005
    ..Plasma fibrinogen levels may be associated with the risk of coronary heart disease (CHD) and stroke...
  41. ncbi request reprint Screening for abdominal aortic aneurysms: the effects of age and social deprivation on screening uptake, prevalence and attendance at follow-up in the MASS trial
    L G Kim
    MRC Biostatistics Unit, Institute of Public Health, University Forvie Site, Robinson Way, Cambridge CB2 2SR, UK
    J Med Screen 11:50-3. 2004
    ..Data from the Multicentre Aneurysm Screening Study (MASS) are used to examine the influences of age and social deprivation in the context of screening for abdominal aortic aneurysms (AAAs)...
  42. ncbi request reprint Baseline adjustments for binary data in repeated cross-sectional cluster randomized trials
    R M Nixon
    MRC Biostatistics Unit, Institute of Public Health, Robinson Way, Cambridge, CB2 2SR, UK
    Stat Med 22:2673-92. 2003
    ....
  43. pmc Bayesian methods for meta-analysis of causal relationships estimated using genetic instrumental variables
    Stephen Burgess
    MRC Biostatistics Unit, Cambridge University, UK
    Stat Med 29:1298-311. 2010
    ..Issues discussed include weak instrument bias, analysis of binary outcome data such as disease risk, missing genetic data, and the use of haplotypes...
  44. ncbi request reprint Flexible parametric models for random-effects distributions
    Katherine J Lee
    MRC Biostatistics Unit, Institute of Public Health, Robinson Way, Cambridge CB2 0SR, UK
    Stat Med 27:418-34. 2008
    ..We conclude that inferences regarding the random effects can crucially depend on the assumptions made and recommend using a distribution, such as those suggested here, which is more flexible than the normal...
  45. ncbi request reprint Meta-analysis of individual patient data to examine factors affecting growth and rupture of small abdominal aortic aneurysms
    M J Sweeting
    MRC Biostatistics Unit, Institute of Public Health, London, UK
    Br J Surg 99:655-65. 2012
    ..Surveillance is a common management strategy for small abdominal aortic aneurysm (AAA) (3.0-5.4 cm in diameter). Individual characteristics, other than diameter, may influence aneurysm growth or rupture rates...
  46. ncbi request reprint Probabilities of progression of aortic aneurysms: estimates and implications for screening policy
    E Couto
    MRC Biostatistics Unit, Institute of Public Health, Robinson Way, Cambridge CB2 2SR, UK
    J Med Screen 9:40-2. 2002
    ..If a screening programme is implemented, it is essential to determine appropriate follow up intervals for rescreening. This paper estimates probabilities of progression growth of aortic diameter to provide evidence for this...
  47. ncbi request reprint Meta-analysis of individual patient data from randomized trials: a review of methods used in practice
    Mark C Simmonds
    MRC Biostatistics Unit, Robinson Way, Cambridge, UK
    Clin Trials 2:209-17. 2005
    ..Meta-analyses based on individual patient data (IPD) are regarded as the gold standard for systematic reviews. However, the methods used for analysing and presenting results from IPD meta-analyses have received little discussion...
  48. pmc Two-stage designs optimal under the alternative hypothesis for phase II cancer clinical trials
    A P Mander
    MRC Biostatistics Unit Hub for Trials Methodology Research, Institute of Public Health, Robinson Way, Cambridge, CB2 0SR, United Kingdom
    Contemp Clin Trials 31:572-8. 2010
    ..We conclude that it is relevant to consider optimal designs under a range of hypotheses about the true response rate, and that allowing early stopping for efficacy is always advantageous in terms of expected sample size...
  49. ncbi request reprint The use of hospital admission data as a measure of outcome in clinical studies of heart failure
    C Metcalfe
    Medical Research Council Biostatistics Unit, Institute of Public Health, Cambridge, UK
    Eur Heart J 24:105-12. 2003
    ..To describe and evaluate the methods currently used to summarize, depict, and analyse hospitalization data in clinical studies of patients with heart failure...
  50. ncbi request reprint Use of angiotensin converting enzyme inhibitors is associated with increased growth rate of abdominal aortic aneurysms
    Michael J Sweeting
    MRC Biostatistics Unit, Institute of Public Health, Cambridge, United Kingdom
    J Vasc Surg 52:1-4. 2010
    ..To evaluate whether either angiotensin converting enzyme (ACE) inhibitors or other classes of antihypertensive drug attenuate or increase growth rates of small infrarenal abdominal aortic aneurysms...
  51. ncbi request reprint Improving costing methods in multicentre economic evaluation: the use of multiple imputation for unit costs
    Richard Grieve
    Health Services Research Unit, London School of Hygiene and Tropical Medicine, Cambridge, UK
    Health Econ 19:939-54. 2010
    ....
  52. pmc Poorer self assessed health in a prospective study of men with screen detected abdominal aortic aneurysm: a predictor or a consequence of screening outcome?
    Theresa M Marteau
    Health Psychology Section Guy s, 5th Floor Thomas Guy House, London Bridge, London SE1 9RT, UK
    J Epidemiol Community Health 58:1042-6. 2004
    ..To assess the extent to which poorer self assessed health in men in whom an abdominal aortic aneurysm (AAA) is detected at screening is a consequence or a predictor of screening outcome...
  53. ncbi request reprint Regression dilution methods for meta-analysis: assessing long-term variability in plasma fibrinogen among 27,247 adults in 15 prospective studies
    Angela M Wood
    Int J Epidemiol 35:1570-8. 2006
    ..The extent of this regression dilution bias for plasma fibrinogen was investigated using repeat measurement data collected at varying time intervals on 27 247 adults in 15 prospective studies...
  54. ncbi request reprint Analyzing the duration of recurrent events in clinical trials: a comparison of approaches using data from the UK700 trial of psychiatric case management
    Chris Metcalfe
    Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Road, Bristol, BS8 2PR, United Kingdom
    Contemp Clin Trials 26:443-58. 2005
    ..We conclude that total duration is an appropriate primary outcome for clinical trials, but that multi-state models deserve greater use as an informative secondary analysis...
  55. ncbi request reprint The importance of varying the event generation process in simulation studies of statistical methods for recurrent events
    Chris Metcalfe
    Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Road, Bristol BS8 2PR, UK
    Stat Med 25:165-79. 2006
    ..In conclusion, it is important that simulation studies of statistical methods for recurrent events include simulated data sets based upon a range of models for event generation...
  56. ncbi request reprint Randomized trial to determine the effect of nebivolol on mortality and cardiovascular hospital admission in elderly patients with heart failure (SENIORS)
    Marcus D Flather
    Clinical Trials and Evaluation Unit, Royal Brompton and Harefield NHS Trust, London, UK
    Eur Heart J 26:215-25. 2005
    ..The SENIORS study was performed to assess effects of the beta-blocker, nebivolol, in patients >/=70 years, regardless of ejection fraction...
  57. ncbi request reprint Abdominal aortic aneurysm expansion: risk factors and time intervals for surveillance
    Anthony R Brady
    MRC Clinical Trials Unit, London, UK
    Circulation 110:16-21. 2004
    ..The aim of this study was to characterize AAA growth in a national cohort of patients with AAA both overall and by cardiovascular risk factors...
  58. ncbi request reprint Multilevel models for estimating incremental net benefits in multinational studies
    Richard Grieve
    Department of Public Health and Policy, London School of Hygiene and Tropical Medicine, London, UK
    Health Econ 16:815-26. 2007
    ..We conclude that the validity of assumptions underlying MLMs used in CEA need to be critically evaluated before reliable conclusions can be drawn...
  59. ncbi request reprint Wei, Lin and Weissfeld's marginal analysis of multivariate failure time data: should it be applied to a recurrent events outcome?
    Chris Metcalfe
    Department of Social Medicine, University of Bristol, Canynge Hall, Bristol, UK
    Stat Methods Med Res 16:103-22. 2007
    ....
  60. ncbi request reprint Using multilevel models for assessing the variability of multinational resource use and cost data
    Richard Grieve
    Department of Public Health and Policy, London School of Hygiene and Tropical Medicine, London, UK
    Health Econ 14:185-96. 2005
    ..We conclude that using OLS models for assessing international variation can lead to incorrect inferences, and that MLMs are more appropriate for assessing why resource use and costs vary across centres...
  61. ncbi request reprint Intensive case management for severe psychotic illness: is there a general benefit for patients with complex needs? A secondary analysis of the UK700 trial data
    Chris Metcalfe
    Dept of Social Medicine, University of Bristol, Canynge Hall, Bristol, BS8 2PR, UK
    Soc Psychiatry Psychiatr Epidemiol 40:718-24. 2005
    ..The benefit of ICM for patients with borderline intelligence is an isolated effect which should be interpreted cautiously until further data are available...
  62. ncbi request reprint Turning the pump handle: evolving methods for integrating the evidence on gene-disease association
    Julian P T Higgins
    Am J Epidemiol 166:863-6. 2007
  63. ncbi request reprint The rupture rate of large abdominal aortic aneurysms: is this modified by anatomical suitability for endovascular repair?
    Janet T Powell
    Department of Vascular Surgery, Imperial College at Charing Cross, London, United Kingdom
    Ann Surg 247:173-9. 2008
    ..There are no precise estimates of the rate of rupture of large abdominal aortic aneurysms (AAA). There is recent suspicion that anatomic suitability for endovascular repair may be associated with a decreased risk of AAA rupture...