John R Thompson

Summary

Affiliation: University of Leicester
Country: UK

Publications

  1. ncbi request reprint Meta-analysis of genetic studies using Mendelian randomization--a multivariate approach
    John R Thompson
    Department of Health Sciences, Centre for Biostatistics and Genetic Epidemiology, University of Leicester, 22 28 Princess Rd West, Leicester, LE1 6TP, U K
    Stat Med 24:2241-54. 2005
  2. pmc SNP prioritization using a Bayesian probability of association
    John R Thompson
    Department of Health Sciences, University of Leicester, Leicester, United Kingdom
    Genet Epidemiol 37:214-21. 2013
  3. doi request reprint A regulatory SNP of the BICD1 gene contributes to telomere length variation in humans
    Massimo Mangino
    Department of Cardiovascular Sciences, University of Leicester, Leicester, UK
    Hum Mol Genet 17:2518-23. 2008
  4. doi request reprint Meta-analysis of Mendelian randomization studies incorporating all three genotypes
    Tom M Palmer
    Department of Health Sciences, University of Leicester, Leicester, UK
    Stat Med 27:6570-82. 2008
  5. pmc Use of Bayesian multivariate meta-analysis to estimate the HAQ for mapping onto the EQ-5D questionnaire in rheumatoid arthritis
    Sylwia Bujkiewicz
    Biostatistics Research Group, Department of Health Sciences, University of Leicester, Leicester, UK Electronic address
    Value Health 17:109-15. 2014
  6. pmc Genetic architecture of ambulatory blood pressure in the general population: insights from cardiovascular gene-centric array
    Maciej Tomaszewski
    Department of Cardiovascular Sciences, University of Leicester, Clinical Sciences Wing, Glenfield Hospital, Leicester, UK
    Hypertension 56:1069-76. 2010
  7. pmc Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants
    Paul R Burton
    Genetic Epidemiology Group, Department of Health Sciences, University of Leicester, Adrian Building, University Road, Leicester LE1 7RH, UK
    Nat Genet 39:1329-37. 2007
  8. pmc Identification of seven loci affecting mean telomere length and their association with disease
    Veryan Codd
    Department of Cardiovascular Sciences, University of Leicester, Leicester, UK
    Nat Genet 45:422-7, 427e1-2. 2013
  9. ncbi request reprint The choice of a genetic model in the meta-analysis of molecular association studies
    Cosetta Minelli
    Department of Health Sciences, Centre for Biostatistics and Genetic Epidemiology, University of Leicester, Leicester, UK
    Int J Epidemiol 34:1319-28. 2005
  10. pmc Common variants near TERC are associated with mean telomere length
    Veryan Codd
    Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester, UK
    Nat Genet 42:197-9. 2010

Detail Information

Publications43

  1. ncbi request reprint Meta-analysis of genetic studies using Mendelian randomization--a multivariate approach
    John R Thompson
    Department of Health Sciences, Centre for Biostatistics and Genetic Epidemiology, University of Leicester, 22 28 Princess Rd West, Leicester, LE1 6TP, U K
    Stat Med 24:2241-54. 2005
    ..We show how either maximum likelihood or a Bayesian approach with vague prior distributions can be used to fit the alternative model...
  2. pmc SNP prioritization using a Bayesian probability of association
    John R Thompson
    Department of Health Sciences, University of Leicester, Leicester, United Kingdom
    Genet Epidemiol 37:214-21. 2013
    ....
  3. doi request reprint A regulatory SNP of the BICD1 gene contributes to telomere length variation in humans
    Massimo Mangino
    Department of Cardiovascular Sciences, University of Leicester, Leicester, UK
    Hum Mol Genet 17:2518-23. 2008
    ..004). BICD1 is involved in Golgi-to-endoplasmic reticulum vacuolar transport. Previous studies have implicated vacuolar genes in telomere length homeostasis in yeast. Our study indicates that BICD1 plays a similar role in humans...
  4. doi request reprint Meta-analysis of Mendelian randomization studies incorporating all three genotypes
    Tom M Palmer
    Department of Health Sciences, University of Leicester, Leicester, UK
    Stat Med 27:6570-82. 2008
    ..The methods are illustrated using a meta-analysis of the effect of a gene related to collagen production on bone mineral density and osteoporotic fracture...
  5. pmc Use of Bayesian multivariate meta-analysis to estimate the HAQ for mapping onto the EQ-5D questionnaire in rheumatoid arthritis
    Sylwia Bujkiewicz
    Biostatistics Research Group, Department of Health Sciences, University of Leicester, Leicester, UK Electronic address
    Value Health 17:109-15. 2014
    ..Therefore, alternative clinical outcomes, including surrogate end points, are increasingly being considered for use in evidence synthesis as part of economic evaluation...
  6. pmc Genetic architecture of ambulatory blood pressure in the general population: insights from cardiovascular gene-centric array
    Maciej Tomaszewski
    Department of Cardiovascular Sciences, University of Leicester, Clinical Sciences Wing, Glenfield Hospital, Leicester, UK
    Hypertension 56:1069-76. 2010
    ....
  7. pmc Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants
    Paul R Burton
    Genetic Epidemiology Group, Department of Health Sciences, University of Leicester, Adrian Building, University Road, Leicester LE1 7RH, UK
    Nat Genet 39:1329-37. 2007
    ....
  8. pmc Identification of seven loci affecting mean telomere length and their association with disease
    Veryan Codd
    Department of Cardiovascular Sciences, University of Leicester, Leicester, UK
    Nat Genet 45:422-7, 427e1-2. 2013
    ..014). Our findings support a causal role of telomere-length variation in some age-related diseases...
  9. ncbi request reprint The choice of a genetic model in the meta-analysis of molecular association studies
    Cosetta Minelli
    Department of Health Sciences, Centre for Biostatistics and Genetic Epidemiology, University of Leicester, Leicester, UK
    Int J Epidemiol 34:1319-28. 2005
    ..A biological justification for the choice of the genetic model is seldom available...
  10. pmc Common variants near TERC are associated with mean telomere length
    Veryan Codd
    Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester, UK
    Nat Genet 42:197-9. 2010
    ..Each copy of the minor allele of rs12696304 was associated with an approximately 75-base-pair reduction in mean telomere length, equivalent to approximately 3.6 years of age-related telomere-length attrition...
  11. ncbi request reprint An integrated approach to the meta-analysis of genetic association studies using Mendelian randomization
    Cosetta Minelli
    Centre for Biostatistics and Genetic Epidemiology, Department of Health Sciences, Leicester Medical School, University of Leicester, 22 28 Princess Road West, Leicester LE1 6TP, United Kingdom
    Am J Epidemiol 160:445-52. 2004
    ..Serious biases may arise if the assumptions behind the analysis based on Mendelian randomization are not met...
  12. doi request reprint Adjusting for bias and unmeasured confounding in Mendelian randomization studies with binary responses
    Tom M Palmer
    Department of Health Sciences, University of Leicester, UK
    Int J Epidemiol 37:1161-8. 2008
    ..When the linearity assumption between the variables does not hold the IV estimates will be biased. The extent of this bias in the phenotype-disease log odds ratio of a Mendelian randomization study is investigated...
  13. pmc Genomewide association analysis of coronary artery disease
    Nilesh J Samani
    University of Leicester, Leicester, United Kingdom
    N Engl J Med 357:443-53. 2007
    ..Modern genotyping platforms permit a systematic search for inherited components of complex diseases. We performed a joint analysis of two genomewide association studies of coronary artery disease...
  14. ncbi request reprint The interleukin-10-1082 'A' allele and abdominal aortic aneurysms
    Matthew J Bown
    Department of Cardiovascular Sciences, University of Leicester, Leicester, UK
    J Vasc Surg 46:687-93. 2007
    ..The aim of this study was to determine whether this polymorphism is associated with AAA and also examine its effect on the growth of small AAA...
  15. ncbi request reprint Evidence-based sample size calculations based upon updated meta-analysis
    Alexander J Sutton
    Department of Health Sciences, University of Leicester, Leicester, UK
    Stat Med 26:2479-500. 2007
    ..This raises issues regarding the appropriateness of the use of random effect models when designing and drawing inferences across a series of studies...
  16. pmc Multivariate meta-analysis of mixed outcomes: a Bayesian approach
    Sylwia Bujkiewicz
    Biostatistics Research Group, Department of Health Sciences, University of Leicester, University Road, Leicester, LE1 7RH, U K
    Stat Med 32:3926-43. 2013
    ..We have applied this model to a motivating example in rheumatoid arthritis with the aim of incorporating all available evidence in the synthesis and potentially reducing uncertainty around the estimate of interest...
  17. ncbi request reprint Bayesian implementation of a genetic model-free approach to the meta-analysis of genetic association studies
    Cosetta Minelli
    Centre for Biostatistics and Genetic Epidemiology, Department of Health Sciences, University of Leicester, Leicester, UK
    Stat Med 24:3845-61. 2005
    ..However, under some circumstances the prospective likelihood has been shown to produce identical results and it is usually preferred for its simplicity. In our meta-analyses the two likelihoods give very similar results...
  18. ncbi request reprint Telomere length, risk of coronary heart disease, and statin treatment in the West of Scotland Primary Prevention Study: a nested case-control study
    Scott W Brouilette
    Department of Cardiovascular Sciences, University of Leicester, Leicester, UK
    Lancet 369:107-14. 2007
    ..Inter-individual differences in biological ageing could affect susceptibility to coronary heart disease. Our aim was to determine whether mean leucocyte telomere length is a predictor of the development of coronary heart disease...
  19. ncbi request reprint LGALS2 functional variant rs7291467 is not associated with susceptibility to myocardial infarction in Caucasians
    Massimo Mangino
    Department of Cardiovascular Sciences, University of Leicester, Clinical Sciences Wing, Glenfield Hospital, Groby Road, Leicester LE3 9QP, UK
    Atherosclerosis 194:112-5. 2007
    ..Despite this, we found no significant association of allele frequency with risk of MI. Stratification for age, gender and other cardiovascular risk factors also failed to reveal an association of this polymorphism with MI...
  20. pmc Urotensin-II system in genetic control of blood pressure and renal function
    Radoslaw Debiec
    Department of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom
    PLoS ONE 8:e83137. 2013
    ..The signatures of evolutionary forces acting on urotensin-II system indicate that it may have evolved towards loss of function since the divergence of primates. ..
  21. ncbi request reprint Dimorphism in the P2Y1 ADP receptor gene is associated with increased platelet activation response to ADP
    Simon L Hetherington
    Department of Cardiovascular Sciences, University of Leicester, United Kingdom
    Arterioscler Thromb Vasc Biol 25:252-7. 2005
    ..There is marked interindividual variation in platelet response to ADP. We studied whether genetic variants in the P2Y1 or P2Y12 genes affect platelet response to ADP...
  22. ncbi request reprint Using pseudo-data to correct for publication bias in meta-analysis
    Jack Bowden
    Department of Health Sciences, Centre for Biostatistics and Genetic Epidemiology, University of Leicester, Leicester, UK
    Stat Med 25:3798-813. 2006
    ..This method can be thought of as an example of the selection model approach to publication bias correction. As the selection mechanism must be assumed, it is important to investigate the sensitivity of any conclusions to this assumption...
  23. ncbi request reprint Estimating and modeling the cure fraction in population-based cancer survival analysis
    Paul C Lambert
    Department of Health Sciences, Centre for Biostatistics and Genetic Epidemiology, University of Leicester, 22 28 Princess Road West, Leicester LE1 6TP, UK
    Biostatistics 8:576-94. 2007
    ..We compare the estimates of relative survival and the cure fraction between the 2 types of model and also investigate the importance of modeling the ancillary parameters in the selected parametric distribution for both types of model...
  24. ncbi request reprint Resuscitated cardiac arrest and prognosis following myocardial infarction
    Albert E Alahmar
    Department of Cardiovascular Sciences, University of Leicester, and Leicester NIHR Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester, UK
    Heart 100:1125-32. 2014
    ..To determine whether resuscitated cardiac arrest (CA) complicating ST elevation myocardial infarction (STEMI) impacts outcome, particularly in patients surviving to discharge...
  25. pmc Mapping of a major locus that determines telomere length in humans
    Mariuca Vasa-Nicotera
    Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester LE3 9QP, United Kingdom
    Am J Hum Genet 76:147-51. 2005
    ..Identification of the gene involved and elucidation of its mechanism of action could have important implications for our understanding of chromosomal assembly, telomere biology, and susceptibility to age-related diseases...
  26. doi request reprint The prevalence of nystagmus: the Leicestershire nystagmus survey
    Nagini Sarvananthan
    Department of Ophthalmology, University of Leicester and Leicester Royal Infirmary, Leicester, United Kingdom
    Invest Ophthalmol Vis Sci 50:5201-6. 2009
    ..The authors carried out the first epidemiologic study to specifically establish the prevalence of nystagmus in Leicestershire and Rutland in the United Kingdom...
  27. ncbi request reprint Genotypes and haplotypes predisposing to myocardial infarction: a multilocus case-control study
    Martin D Tobin
    Centre for Biostatistics and Genetic Epidemiology, Department of Health Sciences, University of Leicester, 22 28 Princess Road West, Leicester LE1 6TP, UK
    Eur Heart J 25:459-67. 2004
    ..To identify polymorphisms and haplotypes in candidate genes that predispose to myocardial infarction (MI) using a multilocus approach...
  28. ncbi request reprint Commentary: development of Mendelian randomization: from hypothesis test to 'Mendelian deconfounding'
    Martin D Tobin
    University of Leicester, Department of Epidemiology and Public Health, 22 28 Princess Road West, Leicester LE1 6TP, UK
    Int J Epidemiol 33:26-9. 2004
  29. ncbi request reprint Turning the pump handle: evolving methods for integrating the evidence on gene-disease association
    Julian P T Higgins
    Am J Epidemiol 166:863-6. 2007
  30. ncbi request reprint White cell telomere length and risk of premature myocardial infarction
    Scott Brouilette
    Division of Cardiology, Department of Medicine, University of Leicester, United Kingdom
    Arterioscler Thromb Vasc Biol 23:842-6. 2003
    ..Mean telomeres lengths provide an assessment of biological age with shorter telomeres, indicating increased biological age. We investigated whether subjects with premature myocardial infarction (MI) had shorter leukocyte telomeres...
  31. pmc Bivariate random-effects meta-analysis and the estimation of between-study correlation
    Richard D Riley
    Centre for Medical Statistics and Health Evaluation, School of Health Sciences, University of Liverpool, Shelley s Cottage, Brownlow Street, Liverpool, L69 3GS, UK
    BMC Med Res Methodol 7:3. 2007
    ..A multivariate random-effects meta-analysis must incorporate and estimate the between-study correlation (rhoB)...
  32. pmc Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes
    Eleftheria Zeggini
    Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, OX3 7LJ, UK
    Science 316:1336-41. 2007
    ..The regions identified underscore the importance of pathways influencing pancreatic beta cell development and function in the etiology of type 2 diabetes...
  33. ncbi request reprint Re: Estimation of bias in nongenetic observational studies using "Mendelian triangulation" by Bautista et al
    Duncan C Thomas
    Ann Epidemiol 17:511-3. 2007
  34. doi request reprint Biostatistical aspects of genome-wide association studies
    Andreas Ziegler
    Institut fur Medizinische Biometrie und Statistik, Universitat zu Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Biom J 50:8-28. 2008
    ..Another aspect of GWAs requiring special attention is the search for gene-gene and gene-environment interactions. We finally describe multistage approaches to GWAs...
  35. pmc Repeated replication and a prospective meta-analysis of the association between chromosome 9p21.3 and coronary artery disease
    Heribert Schunkert
    Medizinische Klinik II, Universitat zu Lubeck, Lubeck, Germany
    Circulation 117:1675-84. 2008
    ..3 as affecting the risk of coronary artery disease (CAD). We investigated the association of this locus with CAD in 7 case-control studies and undertook a meta-analysis...
  36. pmc Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease
    Sheila A Fisher
    Department of Medical and Molecular Genetics, King s College London School of Medicine, 8th Floor Guy s Tower, Guy s Hospital, London SE1 9RT, UK
    Nat Genet 40:710-2. 2008
    ..These data provide the first detailed illustration of the genetic relationship between these common inflammatory bowel diseases...
  37. pmc Common variants near MC4R are associated with fat mass, weight and risk of obesity
    Ruth J F Loos
    MRC Epidemiology Unit, Addenbrooke s Hospital, Cambridge CB2 0QQ, UK
    Nat Genet 40:768-75. 2008
    ....
  38. ncbi request reprint An alternative model for bivariate random-effects meta-analysis when the within-study correlations are unknown
    Richard D Riley
    Centre for Medical Statistics and Health Evaluation, Faculty of Medicine, University of Liverpool, Liverpool, England L69 3GS
    Biostatistics 9:172-86. 2008
    ..The alternative model greatly facilitates the utilization of correlation in meta-analysis and should allow an increased application of BRMA in practice...
  39. pmc Serious complications of local anaesthesia for cataract surgery: a 1 year national survey in the United Kingdom
    Tom Eke
    Norfolk and Norwich University Hospitals NHS Trust, Colney Lane, Norwich NR4 7UY, UK
    Br J Ophthalmol 91:470-5. 2007
    ..The techniques of sub-Tenon's, topical and topical-intracameral local anaesthesia (LA) have become common in routine practice...
  40. doi request reprint A novel selective peroxisome proliferator-activator receptor-gamma modulator-SPPARgammaM5 improves insulin sensitivity with diminished adverse cardiovascular effects
    Ching H Chang
    Department of Pharmacology, Merck Research Laboratories, Rahway, NJ 07065, USA
    Eur J Pharmacol 584:192-201. 2008
    ..Thus, compounds such as SPPARgammaM5 may offer beneficial effects on glycemic control with significantly attenuated adverse effects...
  41. ncbi request reprint How should we use information about HWE in the meta-analyses of genetic association studies?
    Cosetta Minelli
    Respiratory Epidemiology and Public Health Group, National Heart and Lung Institute, Imperial College London, SW3 6LR, London, UK
    Int J Epidemiol 37:136-46. 2008
    ..However, tests for HWE have low power and there is currently no consensus about how to handle studies that deviate significantly from HWE...
  42. ncbi request reprint Factors associated with success in first-time trabeculectomy for patients at low risk of failure with chronic open-angle glaucoma
    Beth Edmunds
    Royal College of Ophthalmologists, London, United Kingdom
    Ophthalmology 111:97-103. 2004
    ..To examine the relationships between study factors and trabeculectomy outcome in a representative sample of United Kingdom ophthalmology surgeons and patients...