Jennifer C Thompson

Summary

Affiliation: University of Manchester
Country: UK

Publications

  1. doi request reprint Longitudinal evaluation of neuropsychiatric symptoms in Huntington's disease
    Jennifer C Thompson
    Cerebral Function Unit, Greater Manchester Neuroscience Centre, Salford Royal NHS Foundation Trust, Salford, UK
    J Neuropsychiatry Clin Neurosci 24:53-60. 2012
  2. pmc Qualitative neuropsychological performance characteristics in frontotemporal dementia and Alzheimer's disease
    J C Thompson
    Cerebral Function Unit, Greater Manchester Neuroscience Centre, Hope Hospital, Salford M6 8HD, UK
    J Neurol Neurosurg Psychiatry 76:920-7. 2005
  3. doi request reprint Automaticity and attention in Huntington's disease: when two hands are not better than one
    Jennifer C Thompson
    Cerebral Function Unit, Greater Manchester Neuroscience Centre, Salford Royal NHS Foundation Trust, M6 8HD, UK
    Neuropsychologia 48:171-8. 2010
  4. doi request reprint Classification and pathology of primary progressive aphasia
    Jennifer M Harris
    From the Manchester Academic Health Sciences Centre J M H, C G, J C T, A M T R, D N, D d P, P P, D M A M, J S S, M J, Cerebral Function Unit, Greater Manchester Neuroscience Centre, Salford Royal NHS Foundation Trust, Salford and Institute of Brain, Behaviour and Mental Health J M H, D N, D M A M, J S S, M J, University of Manchester, UK
    Neurology 81:1832-9. 2013
  5. doi request reprint Variability in cognitive presentation of Alzheimer's disease
    Cheryl L Stopford
    Cerebral Function Unit, Greater Manchester Neuroscience Centre, Salford Royal Hospital NHS Foundation Trust, Salford, UK
    Cortex 44:185-95. 2008
  6. doi request reprint Working memory, attention, and executive function in Alzheimer's disease and frontotemporal dementia
    Cheryl L Stopford
    Cerebral Function Unit, Greater Manchester Neuroscience Centre, Salford Royal NHS Foundation Trust, UK
    Cortex 48:429-46. 2012
  7. pmc Distinct clinical and pathological characteristics of frontotemporal dementia associated with C9ORF72 mutations
    Julie S Snowden
    Cerebral Function Unit, Greater Manchester Neuroscience Centre, Salford Royal Foundation Trust, Salford, M6 8HD, UK
    Brain 135:693-708. 2012
  8. doi request reprint Do NIA-AA criteria distinguish Alzheimer's disease from frontotemporal dementia?
    Jennifer M Harris
    Manchester Academic Health Sciences Centre, Cerebral Function Unit, Greater Manchester Neuroscience Centre, Salford Royal NHS Foundation Trust, Salford, UK Institute of Brain, Behaviour and Mental Health, University of Manchester, Manchester, UK
    Alzheimers Dement 11:207-15. 2015
  9. doi request reprint Sensitivity and specificity of FTDC criteria for behavioral variant frontotemporal dementia
    Jennifer M Harris
    Manchester Academic Health Sciences Centre, Cerebral Function Unit, Greater Manchester Neuroscience Centre, Salford Royal NHS Foundation Trust, Salford, UK
    Neurology 80:1881-7. 2013
  10. doi request reprint Cognitive phenotypes in Alzheimer's disease and genetic variants in ACE and IDE
    Emma R L C Vardy
    Cerebral Function Unit, Salford Royal NHS Foundation Trust, Salford, UK
    Neurobiol Aging 33:1486.e1-2. 2012

Collaborators

Detail Information

Publications32

  1. doi request reprint Longitudinal evaluation of neuropsychiatric symptoms in Huntington's disease
    Jennifer C Thompson
    Cerebral Function Unit, Greater Manchester Neuroscience Centre, Salford Royal NHS Foundation Trust, Salford, UK
    J Neuropsychiatry Clin Neurosci 24:53-60. 2012
    ..Depression did not increase significantly at any stage of disease. The neuropsychiatric syndrome of apathy appears to be intrinsic to the evolution and progression of HD...
  2. pmc Qualitative neuropsychological performance characteristics in frontotemporal dementia and Alzheimer's disease
    J C Thompson
    Cerebral Function Unit, Greater Manchester Neuroscience Centre, Hope Hospital, Salford M6 8HD, UK
    J Neurol Neurosurg Psychiatry 76:920-7. 2005
    ..A possible reason is that studies typically rely on overall accuracy scores, which may obscure differences in reasons for failure...
  3. doi request reprint Automaticity and attention in Huntington's disease: when two hands are not better than one
    Jennifer C Thompson
    Cerebral Function Unit, Greater Manchester Neuroscience Centre, Salford Royal NHS Foundation Trust, M6 8HD, UK
    Neuropsychologia 48:171-8. 2010
    ..The findings have implications for the interpretation of 'high level' deficits in attention and executive function previously reported in HD...
  4. doi request reprint Classification and pathology of primary progressive aphasia
    Jennifer M Harris
    From the Manchester Academic Health Sciences Centre J M H, C G, J C T, A M T R, D N, D d P, P P, D M A M, J S S, M J, Cerebral Function Unit, Greater Manchester Neuroscience Centre, Salford Royal NHS Foundation Trust, Salford and Institute of Brain, Behaviour and Mental Health J M H, D N, D M A M, J S S, M J, University of Manchester, UK
    Neurology 81:1832-9. 2013
    ..We aimed to determine the extent to which patients with progressive language impairment conform to 2011 primary progressive aphasia (PPA) classification and to examine clinicopathologic correlations within PPA variants...
  5. doi request reprint Variability in cognitive presentation of Alzheimer's disease
    Cheryl L Stopford
    Cerebral Function Unit, Greater Manchester Neuroscience Centre, Salford Royal Hospital NHS Foundation Trust, Salford, UK
    Cortex 44:185-95. 2008
    ..The findings emphasise variability in presentation and indicate that distinct phenotypic variations appear to lie on a continuum rather than representing discrete forms of disease...
  6. doi request reprint Working memory, attention, and executive function in Alzheimer's disease and frontotemporal dementia
    Cheryl L Stopford
    Cerebral Function Unit, Greater Manchester Neuroscience Centre, Salford Royal NHS Foundation Trust, UK
    Cortex 48:429-46. 2012
    ..They underline also the phenotypic variation within AD...
  7. pmc Distinct clinical and pathological characteristics of frontotemporal dementia associated with C9ORF72 mutations
    Julie S Snowden
    Cerebral Function Unit, Greater Manchester Neuroscience Centre, Salford Royal Foundation Trust, Salford, M6 8HD, UK
    Brain 135:693-708. 2012
    ..Mutations in the C9ORF72 gene may be a major cause not only of frontotemporal dementia with motor neuron disease but also of late onset psychosis...
  8. doi request reprint Do NIA-AA criteria distinguish Alzheimer's disease from frontotemporal dementia?
    Jennifer M Harris
    Manchester Academic Health Sciences Centre, Cerebral Function Unit, Greater Manchester Neuroscience Centre, Salford Royal NHS Foundation Trust, Salford, UK Institute of Brain, Behaviour and Mental Health, University of Manchester, Manchester, UK
    Alzheimers Dement 11:207-15. 2015
    ..Clinical criteria are important for improving diagnostic accuracy and ensuring comparability of patient cohorts in research studies...
  9. doi request reprint Sensitivity and specificity of FTDC criteria for behavioral variant frontotemporal dementia
    Jennifer M Harris
    Manchester Academic Health Sciences Centre, Cerebral Function Unit, Greater Manchester Neuroscience Centre, Salford Royal NHS Foundation Trust, Salford, UK
    Neurology 80:1881-7. 2013
    ..We aimed to assess sensitivity and specificity of the updated criteria for behavioral variant frontotemporal dementia (bvFTD) based on a large autopsy-confirmed cohort of patients with dementia...
  10. doi request reprint Cognitive phenotypes in Alzheimer's disease and genetic variants in ACE and IDE
    Emma R L C Vardy
    Cerebral Function Unit, Salford Royal NHS Foundation Trust, Salford, UK
    Neurobiol Aging 33:1486.e1-2. 2012
    ..Of the 10 genetic variants of IDE, and the 3 genetic variants of ACE studied, only ACErs4291 and ACErs1800764 were nominally associated with the amnestic presentation...
  11. doi request reprint Frontotemporal dementia with amyotrophic lateral sclerosis: a clinical comparison of patients with and without repeat expansions in C9orf72
    Julie S Snowden
    Manchester Academic Health Sciences Centre, Cerebral Function Unit, Greater Manchester Neuroscience Centre, Salford Royal NHS Foundation Trust, Salford, UK
    Amyotroph Lateral Scler Frontotemporal Degener 14:172-6. 2013
    ..The presence of psychiatric symptoms in the context of FTD-ALS should alert clinicians to the possibility of C9orf72 expansions...
  12. doi request reprint Famous people knowledge and the right and left temporal lobes
    Julie S Snowden
    Cerebral Function Unit, Greater Manchester Neuroscience Centre, Salford Royal Foundation Trust, Salford, UK
    Behav Neurol 25:35-44. 2012
    ..The data present a challenge for the influential `semantic hub' model, which views the anterior temporal lobes as an area of convergence in which semantic information is represented in amodal form...
  13. doi request reprint The clinical diagnosis of early-onset dementias: diagnostic accuracy and clinicopathological relationships
    Julie S Snowden
    Cerebral Function Unit, Greater Manchester Neuroscience Centre, Salford Royal NHS Foundation Trust, Salford M6 8HD, UK
    Brain 134:2478-92. 2011
    ..Moreover, careful clinical phenotyping allows prediction of histopathological subtype of frontotemporal lobar degeneration. The principles guiding diagnosis provide the foundation for future prospective studies...
  14. doi request reprint Cognitive-behavioural features of progressive supranuclear palsy syndrome overlap with frontotemporal dementia
    Christopher Kobylecki
    Cerebral Function Unit, Greater Manchester Neurosciences Centre, Salford Royal NHS Foundation Trust, Stott Lane, Salford, M6 8HD, UK
    J Neurol 262:916-22. 2015
    ..Cognitive and behavioural profiling should be an integral part of the assessment of patients with PSPS. ..
  15. doi request reprint Patterns of microglial cell activation in frontotemporal lobar degeneration
    Suzannah B Lant
    Clinical and Cognitive Sciences Research Group, Institute of Brain, Behaviour and Mental Health, Faculty of Medical and Human Sciences, University of Manchester, Salford Royal Hospital, Salford, UK
    Neuropathol Appl Neurobiol 40:686-96. 2014
    ....
  16. pmc Psychiatric disorders in preclinical Huntington's disease
    Camille L Julien
    Cerebral Function Unit, Greater Manchester Neuroscience Centre, Hope Hospital, Salford, UK
    J Neurol Neurosurg Psychiatry 78:939-43. 2007
    ..Few studies have investigated the temporal course of psychiatric disorder across the preclinical period...
  17. ncbi request reprint Distinct memory profiles in Alzheimer's disease
    Cheryl L Stopford
    Cerebral Function Unit, Greater Manchester Neuroscience Centre, Hope Hospital, Salford, UK
    Cortex 43:846-57. 2007
    ..The link between working memory and language performance, together with findings of posterior hemisphere abnormalities on neuroimaging, lead us to reassess the nature of working memory deficits in AD...
  18. doi request reprint Histone deacetylases (HDACs) in frontotemporal lobar degeneration
    Amy Whitehouse
    Clinical and Cognitive Sciences Research Group, Institute of Brain, Behaviour and Mental Health, Faculty of Medical and Human Sciences, University of Manchester, Salford Royal Hospital, Salford, UK
    Neuropathol Appl Neurobiol 41:245-57. 2015
    ..Epigenetic factors such as histone regulation by histone deacetylases (HDAC) may play a role in the dysregulation of transcriptional activity, thought to underpin the neurodegenerative process...
  19. doi request reprint No interaction between tau and TDP-43 pathologies in either frontotemporal lobar degeneration or motor neurone disease
    Andrew C Robinson
    Clinical and Cognitive Sciences Research Group, Institute of Brain, Behaviour and Mental Health, Faculty of Medical and Human Sciences, University of Manchester, Salford Royal Hospital, Salford
    Neuropathol Appl Neurobiol 40:844-54. 2014
    ..While such a classification implies only a single type of protein should be present, recent studies have demonstrated dual tau and TDP-43 proteinopathy can occur, particularly in inherited FTLD...
  20. pmc Brain distribution of dipeptide repeat proteins in frontotemporal lobar degeneration and motor neurone disease associated with expansions in C9ORF72
    Yvonne S Davidson
    Clinical and Cognitive Sciences Research Group, Institute of Brain, Behaviour and Mental Health, Faculty of Medical and Human Sciences, University of Manchester, Salford Royal Hospital, Salford M6 8HD, UK
    Acta Neuropathol Commun 2:70. 2014
    ....
  21. doi request reprint Progressive aphasia presenting with deep dyslexia and dysgraphia
    Julie S Snowden
    Cerebral Function Unit, Greater Manchester Neuroscience Centre, Salford Royal Foundation Trust, Salford, UK
    Cortex 48:1234-9. 2012
    ..TheĀ findings have potential practical implications for speech and language therapy in progressive aphasia. Moreover, they illustrate both the remarkable specificity yet clinical diversity in presentation of progressive aphasia...
  22. doi request reprint TDP-43 pathological changes in early onset familial and sporadic Alzheimer's disease, late onset Alzheimer's disease and Down's syndrome: association with age, hippocampal sclerosis and clinical phenotype
    Yvonne S Davidson
    Mental Health and Neurodegeneration Research Group, Salford Royal Foundation Trust, University of Manchester, Salford M6 8HD, UK
    Acta Neuropathol 122:703-13. 2011
    ..005), but this association disappeared when TDP-43-positive cases were excluded from the analysis. TDP-43 may, after all, be integral to the pathology of AD, and to some extent determine the clinical phenotype present...
  23. ncbi request reprint Behavior in Huntington's disease: dissociating cognition-based and mood-based changes
    Jennifer C Thompson
    Cerebral Function Unit, Greater Manchester Neuroscience Center, Salford, United Kingdom
    J Neuropsychiatry Clin Neurosci 14:37-43. 2002
    ..The findings suggest that certain behavioral alterations are intrinsic to the evolution and progression of HD, whereas others are more variable and are independent of other indices of disease progression...
  24. pmc Dipeptide repeat proteins are present in the p62 positive inclusions in patients with frontotemporal lobar degeneration and motor neurone disease associated with expansions in C9ORF72
    David M A Mann
    Clinical and Cognitive Sciences Research Group, Institute of Brain, Behaviour and Mental Health, Faculty of Medical and Human Sciences, University of Manchester, Salford Royal Hospital, Salford M6 8HD, UK
    Acta Neuropathol Commun 1:68. 2013
    ....
  25. ncbi request reprint Cognitive phenotypes in Alzheimer's disease and genetic risk
    Julie S Snowden
    Clinical Neuroscience Research Group, Greater Manchester Neuroscience Centre, Hope Hospital, Salford, UK
    Cortex 43:835-45. 2007
    ..The findings indicate that risk factors other than APOE epsilon4 allele underlie the non-familial, early onset posterior hemisphere presentations of AD...
  26. doi request reprint Understanding quantity in semantic dementia
    Camille L Julien
    Cerebral Function Unit, Greater Manchester Neuroscience Centre, Salford Royal Foundation Trust, Salford, UK
    Cogn Neuropsychol 27:3-29. 2010
    ..The findings challenge the view that knowledge of quantity is totally preserved in SD and suggest that the temporal lobes have a contributory role in the conceptual understanding of quantity...
  27. ncbi request reprint Knowledge of famous faces and names in semantic dementia
    J S Snowden
    Cerebral Function Unit, Greater Manchester Neuroscience Centre, Hope Hospital, Salford M6 8HD, UK
    Brain 127:860-72. 2004
    ..Moreover, they lead us to argue that the focal syndrome of progressive prosopagnosia is one of the clinical presentations of semantic dementia and not a separate clinical entity...
  28. doi request reprint Emotion recognition in Huntington's disease and frontotemporal dementia
    J S Snowden
    Cerebral Function Unit, Greater Manchester Neuroscience Centre, Salford Royal Foundation Trust, Hope Hospital, Salford, United Kingdom
    Neuropsychologia 46:2638-49. 2008
    ..The data raise the possibility that linguistic influences and conceptual complexities of the emotion of disgust may contribute to the variable finding of selective disgust impairment in HD...
  29. doi request reprint Arithmetic knowledge in semantic dementia: is it invariably preserved?
    C L Julien
    Cerebral Function Unit, Greater Manchester Neuroscience Centre, Salford Royal Hospital, Stott Lane, Salford M6 8HD, UK
    Neuropsychologia 46:2732-44. 2008
    ..The findings challenge the notion of arithmetic knowledge as a totally separate semantic domain and suggest that the temporal lobes play an important role in arithmetic understanding...
  30. ncbi request reprint New learning and remote memory in atypical Alzheimer's disease
    Jennifer C Thompson
    Cerebral Function Unit, Greater Manchester Neuroscience Centre, Hope Hospital, Manchester, Salford, UK
    Cortex 39:751-66. 2003
    ..e. 'old' versus 'recent') are considered, with particular reference to the contrasting theoretical frameworks that have recently been advanced by Squire and Moscovitch...
  31. ncbi request reprint Inferring thought and action in motor neurone disease
    Z C Gibbons
    Cerebral Function Unit, Greater Manchester Neuroscience Centre, Hope Hospital, Salford M6 8HD, UK
    Neuropsychologia 45:1196-207. 2007
    ..The findings contribute to the understanding of ToM performance in neurodegenerative disease and provide further evidence of the association between MND and FTD...
  32. ncbi request reprint Evidence of an early information processing speed deficit in unipolar major depression
    G Tsourtos
    Department of Psychiatry, University of Adelaide, South Australia
    Psychol Med 32:259-65. 2002
    ....