Mark G Thomas
Affiliation: University College London
- Evidence for an apartheid-like social structure in early Anglo-Saxon EnglandMark G Thomas
Department of Biology, University College London, Wolfson House, 4 Stephenson Way, London NW1 2HE, UK
Proc Biol Sci 273:2651-7. 2006....
- The origins of lactase persistence in EuropeYuval Itan
Research Department of Genetics, Evolution and Environment, University College London, London, United Kingdom
PLoS Comput Biol 5:e1000491. 2009..Our results provide a coherent and spatially explicit picture of the coevolution of lactase persistence and dairying in Europe...
- The flickering genes of the last mammothsM G Thomas
Research Department of Genetics, Evolution and Environment, University College London, Gower Street, London WC1E 6BT, UK
Mol Ecol 21:3379-81. 2012..While the ultimate agent of mammoth extinction remains unknown, the work of Nyström et al. (2012). suggests that we should be looking for something sudden, like a rapid change in climate/ecology or perhaps the arrival of humans...
- Little genetic differentiation as assessed by uniparental markers in the presence of substantial language variation in peoples of the Cross River region of NigeriaKrishna R Veeramah
Centre for Society and Genetics, University of California, Los Angeles, 90095 722, USA
BMC Evol Biol 10:92. 2010..In addition the Cross River region was analysed in the context of a larger geographical scale by comparison to bordering Igbo speaking groups as well as neighbouring Cameroon populations and more distant Ghanaian communities...
- New genetic evidence supports isolation and drift in the Ladin communities of the South Tyrolean Alps but not an ancient origin in the Middle EastMark G Thomas
Department of Biology, University College London, London NW1 2HE, UK
Eur J Hum Genet 16:124-34. 2008....
- High throughput analysis of 10 microsatellite and 11 diallelic polymorphisms on the human Y-chromosomeM G Thomas
The Centre for Genetic Anthropology, The Department of Anthropology, University College London, UK
Hum Genet 105:577-81. 1999..The method requires only four PCRs and four GeneScan runs per sample and is relatively insensitive to sample DNA concentration...
- Molecular instability in the COII-tRNA(Lys) intergenic region of the human mitochondrial genome: multiple origins of the 9-bp deletion and heteroplasmy for expanded repeatsM G Thomas
Department of Biological Anthropology, University of Cambridge, UK
Philos Trans R Soc Lond B Biol Sci 353:955-65. 1998..From this we conclude that drift in the germ-line lineage is a main factor in the maintenance or loss of heteroplasmy...
- Multiple rare variants as a cause of a common phenotype: several different lactase persistence associated alleles in a single ethnic groupCatherine J E Ingram
Research Department of Genetics, Evolution and Environment, University College London, Wolfson House, 4 Stephenson Way, London, NW1 2HE, UK
J Mol Evol 69:579-88. 2009..This contrasts with the well-documented observation that positive selection decreases diversity by driving up the frequency of a single advantageous allele, and has implications for association studies...
- A novel polymorphism associated with lactose tolerance in Africa: multiple causes for lactase persistence?Catherine J E Ingram
Department of Biology, Galton Laboratory, University College London, Wolfson House, 4 Stephenson Way, London, UK
Hum Genet 120:779-88. 2007..This study reveals the complexity of this phenotypic polymorphism and highlights the limitations of C-13910T as a diagnostic test for lactase persistence status, at least for people with non-European ancestry...
- Y chromosome evidence for Anglo-Saxon mass migrationMichael E Weale
The Centre for Genetic Anthropology, Departments of Biology and Anthropology, University College London, University of London, United Kingdom
Mol Biol Evol 19:1008-21. 2002....
- Lactose digestion and the evolutionary genetics of lactase persistenceCatherine J E Ingram
Department of Genetics Evolution and Environment, University College London, London, UK
Hum Genet 124:579-91. 2009....
- A worldwide correlation of lactase persistence phenotype and genotypesYuval Itan
Research Department of Genetics, Evolution and Environment, University College London, London WC1E 6BT, UK
BMC Evol Biol 10:36. 2010....
- Diet and the frequency of the alanine:glyoxylate aminotransferase Pro11Leu polymorphism in different human populationsElizabeth F Caldwell
Department of Biology, University College London, Gower Street, London, WC1E 6BT, UK
Hum Genet 115:504-9. 2004....
- Ethiopian genetic diversity reveals linguistic stratification and complex influences on the Ethiopian gene poolLuca Pagani
Division of Biological Anthropology, University of Cambridge, UK
Am J Hum Genet 91:83-96. 2012..Linkage-disequilibrium decay with genomic distance was less rapid in both the whole genome and the African component than in southern African samples, suggesting a less ancient history for Ethiopian populations...
- Evolution of lactase persistence: an example of human niche constructionPascale Gerbault
Research Department of Genetics, Evolution and Environment, University College London, Wolfson House, 4 Stephenson Way, London NW1 2HE, UK
Philos Trans R Soc Lond B Biol Sci 366:863-77. 2011..These studies illustrate how genetic and archaeological information can be integrated to bring new insights to the origins and spread of lactase persistence. Finally, we discuss possible improvements to these models...
- Late Pleistocene demography and the appearance of modern human behaviorAdam Powell
Research Department of Genetics, Evolution, and Environment, University College London, Wolfson House, 4 Stephenson Way, London NW1 2HE, UK
Science 324:1298-301. 2009..Demographic factors can thus explain geographic variation in the timing of the first appearance of modern behavior without invoking increased cognitive capacity...
- The potentially deleterious functional variant flavin-containing monooxygenase 2*1 is at high frequency throughout sub-Saharan AfricaKrishna R Veeramah
The Centre for Genetic Anthropology, Research Department of Genetics, University College, London, UK
Pharmacogenet Genomics 18:877-86. 2008..FMO2 may also be involved in the metabolism of drugs that are used to treat diseases that are prevalent in Africa...
- The T allele of a single-nucleotide polymorphism 13.9 kb upstream of the lactase gene (LCT) (C-13.9kbT) does not predict or cause the lactase-persistence phenotype in AfricansCharlotte A Mulcare
The Centre for Genetic Anthropology TCGA, University College London, London NW1 2HE, United Kingdom
Am J Hum Genet 74:1102-10. 2004..We also present Y-chromosome data that are consistent with previously reported evidence for a back-migration event into Cameroon, and we comment on the implications for the introgression of the -13.9kb*T allele...
- A Y chromosome census of the British IslesCristian Capelli
Department of Biology, University College London, Gower Street, London WC1E 6BT, United Kingdom
Curr Biol 13:979-84. 2003....
- Herders of Indian and European cattle share their predominant allele for lactase persistenceIrene Gallego Romero
Department of Biological Anthropology, Leverhulme Centre for Human Evolutionary Studies, University of Cambridge, Cambridge, United Kingdom
Mol Biol Evol 29:249-60. 2012..We confirm that the mutation is identical by descent to the European allele and is associated with the same>1 Mb extended haplotype in both populations...
- CYP1A2 is more variable than previously thought: a genomic biography of the gene behind the human drug-metabolizing enzymeSarah L Browning
The Centre for Genetic Anthropology, University College London, London, UK
Pharmacogenet Genomics 20:647-64. 2010....
- Prevalence of clinically relevant UGT1A alleles and haplotypes in African populationsLaura J Horsfall
Department of Genetics, Evolution and Environment, University College London, Wolfson House, UK
Ann Hum Genet 75:236-46. 2011....
- Y-chromosome evidence for differing ancient demographic histories in the AmericasMaria Catira Bortolini
Department of Biology, University College, London, United Kingdom
Am J Hum Genet 73:524-39. 2003..Age estimates based on Y-chromosome microsatellite diversity place the initial settlement of the American continent at approximately 14,000 years ago, in relative agreement with the age of well-established archaeological evidence...
- The frequency of an IL-18-associated haplotype in AfricansSimon R Thompson
UCL Centre for Cardiovascular Genetics, Rayne Institute, London, UK
Eur J Hum Genet 21:465-8. 2013..Potentially protective variants may, as a consequence, be found at low frequency in African individuals and may confer a difference in disease risk...
- Genetic evidence for different male and female roles during cultural transitions in the British IslesJ F Wilson
Galton Laboratory, Department of Biology, University College London, Wolfson House, 4 Stephenson Way, London NW1 2HE, United Kingdom
Proc Natl Acad Sci U S A 98:5078-83. 2001..In contrast, patterns of mtDNA and X-chromosome variation indicate that one or more of these pre-Anglo-Saxon cultural revolutions had a major effect on the maternal genetic heritage of the British Isles...
- Founding mothers of Jewish communities: geographically separated Jewish groups were independently founded by very few female ancestorsMark G Thomas
Departments of Biology and Anthropology, The Centre for Genetic Anthropology, University College London, Gower Street, London WC1E 6BT, UK
Am J Hum Genet 70:1411-20. 2002....
- High-throughput analysis of informative CYP2D6 compound haplotypesBenjamin Fletcher
The Centre for Genetic Anthropology, Department of Biology and Department of Anthropology, University College London, UK
Genomics 81:166-74. 2003..1 using microsatellite variation, and (3) generation of compound haplotypes for investigating the evolution of CYP2D6 variation. We also report compound haplotype frequencies for an Ashkenazi Jewish and a British sample...
- Rare deep-rooting Y chromosome lineages in humans: lessons for phylogeographyMichael E Weale
The Centre for Genetic Anthropology, Department of Biology, University College, London WC1E 6BT, United Kingdom
Genetics 165:229-34. 2003..We discuss the problems presented by rare deep-rooting lineages for Y chromosome phylogeography...
- Molecular diversity and population structure at the Cytochrome P450 3A5 gene in AfricaRipudaman K Bains
Research Department of Genetics, Evolution and Environment, University College London, Darwin Building, Gower Street, London, WC1E 6BT, UK
BMC Genet 14:34. 2013..Finally, we examined a hypothesis that CYP3A5 is important in salt retention adaptation by performing correlations with ecological data relating to aridity for the present day, 10,000 and 50,000 years ago...
- Detecting gene duplications in the human lineageYuval Itan
Research Department of Genetics, Evolution and Environment, University College London, UK
Ann Hum Genet 74:555-65. 2010..In this study, we have developed a set of bioinformatic tools to overcome a number of the conceptual problems that are prevalent in previous studies and have collected a reliable and representative set of human inparalogues...
- Presence of a newly described human DNA virus (TTV) in patients with liver diseaseN V Naoumov
Institute of Hepatology, Department of Medicine, University College London Medical School, UK
Lancet 352:195-7. 1998..We investigated the presence of this virus in patients with liver disease in the UK to find out whether TTV infection is associated with liver damage...
- Armenian Y chromosome haplotypes reveal strong regional structure within a single ethno-national groupM E Weale
Centre for Genetic Anthropology, Departments of Biology and Anthropology, University College London, University of London, Darwin Bdg, Gower St, London WC1E 6BT, UK
Hum Genet 109:659-74. 2001....
- AIP mutation in pituitary adenomas in the 18th century and todayHarvinder S Chahal
Department of Endocrinology, Barts and the London School of Medicine, Queen Mary University of London, London, United Kingdom
N Engl J Med 364:43-50. 2011..Using coalescent theory, we infer that these persons share a common ancestor who lived about 57 to 66 generations earlier...
- Regional population collapse followed initial agriculture booms in mid-Holocene EuropeStephen Shennan
Institute of Archaeology, University College London, 31 34 Gordon Square, London WC1H 0PY, UK
Nat Commun 4:2486. 2013..However, we find no evidence to support a relationship. Our results thus suggest that the demographic patterns may have arisen from endogenous causes, although this remains speculative. ..
- Evaluating bacterial pathogen DNA preservation in museum osteological collectionsIan Barnes
Department of Biology, University College London, Gower Street, London WC1E 6BT, UK
Proc Biol Sci 273:645-53. 2006....
- Population genetic structure of variable drug responseJ F Wilson
Galton Laboratory, Department of Biology, University College London, London, UK
Nat Genet 29:265-9. 2001..Our comparison of drug-metabolizing profiles across the inferred clusters establishes a framework for assessing the appropriate level of resolution in relating genetic structure to drug response...
- The phylogenetic position of the 'giant deer' Megaloceros giganteusA M Lister
Department of Biology, University College London, London WC1E 6BT, UK
Nature 438:850-3. 2005..Our results include the successful extraction and sequencing of DNA from this extinct species, and highlight the value of a joint molecular and morphological approach...
- How long have adult humans been consuming milk?Pascale Gerbault
Research Department of Genetics, Evolution and Environment, University College London, London, WC1E 6BT, UK
IUBMB Life 65:983-90. 2013..We review here the archaeological and genetic evidence available that have contributed to a better understanding of the gene-culture co-evolution of LP and dairying...
- Population structure in the Mediterranean basin: a Y chromosome perspectiveC Capelli
Department of Biology, University College of London, London, UK
Ann Hum Genet 70:207-25. 2006..In particular, Near Eastern samples tend to separate according to the presence of Arab Y chromosome lineages, suggesting that the Arab expansion played a major role in shaping the current genetic structuring within the Fertile Crescent...
- Staying out in the cold: glacial refugia and mitochondrial DNA phylogeography in ancient European brown bearsCristina E Valdiosera
Centro Mixto UCM ISCIII de Evolución y Comportamiento Humanos, c Sinesio Delgado 4 Pabellon 14, 28029 Madrid, Spain
Mol Ecol 16:5140-8. 2007..We propose continuous gene flow across southern Europe, from which brown bear populations expanded after the last glaciation...
- Excavating past population structures by surname-based sampling: the genetic legacy of the Vikings in northwest EnglandGeorgina R Bowden
Department of Genetics, University of Leicester, Leicester, United Kingdom
Mol Biol Evol 25:301-9. 2008....
- Mitochondrial DNA analysis shows a Near Eastern Neolithic origin for domestic cattle and no indication of domestication of European aurochsCeiridwen J Edwards
Smurfit Institute of Genetics, Trinity College, Dublin 2, Ireland
Proc Biol Sci 274:1377-85. 2007..During the period of coexistence, it appears that domestic cattle were kept separate from wild aurochs and introgression was extremely rare...
- Multiple origins of Ashkenazi Levites: Y chromosome evidence for both Near Eastern and European ancestriesDoron M Behar
Bruce Rappaport Faculty of Medicine and Research Institute, Technion and Rambam Medical Center, Haifa, Israel
Am J Hum Genet 73:768-79. 2003....
- Normophosphatemic familial tumoral calcinosis is caused by deleterious mutations in SAMD9, encoding a TNF-alpha responsive proteinIlana Chefetz
Laboratory of Molecular Dermatology and Department of Dermatology, Rambam Health Care Campus, Haifa, Israel
J Invest Dermatol 128:1423-9. 2008..These data link NFTC and SAMD9 to the TNF-alpha signaling pathway, suggesting a role for this system in the regulation of extra-osseous calcification...
- Surprising migration and population size dynamics in ancient Iberian brown bears (Ursus arctos)Cristina E Valdiosera
Centro Mixto, Universidad Complutense de Madrid Instituto de Salud Carlos III de Evolución y Comportamiento Humanos, c Sinesio Delgado 4 Pabellon 14, 28029 Madrid, Spain
Proc Natl Acad Sci U S A 105:5123-8. 2008..Thus, the current situation is highly unusual and the population may in fact be isolated for the first time in its history...
- Genetic structure and extinction of the woolly mammoth, Mammuthus primigeniusIan Barnes
School of Biological Sciences, Royal Holloway, University of London, Egham, Surrey TW20 0EX, United Kingdom
Curr Biol 17:1072-5. 2007..The most marked change in diversity at this time is the loss of one of two major mitochondrial lineages...
- Effects of intravenous zoledronate on bone turnover and BMD persist for at least 24 monthsMark J Bolland
Department of Medicine, University of Auckland, Auckland, New Zealand
J Bone Miner Res 23:1304-8. 2008..Randomized trials that address this issue should be performed...
- Skin infections of the limbs of Polynesian childrenMark G Thomas
N Z Med J 117:U1059. 2004
- A new time-scale for ray-finned fish evolutionImogen A Hurley
Department of Organismal Biology and Anatomy, University of Chicago, Chicago, IL 60637, USA
Proc Biol Sci 274:489-98. 2007..While the date estimate of this event overlaps the probable range of the teleost stem group, a correlation between the genome duplication and the large-scale pattern of actinopterygian phylogeny remains elusive...
- Tuberculosis in New Zealand: poverty casts a long shadowMark G Thomas
N Z Med J 119:U2267. 2006
- Bone mineral density is not reduced in HIV-infected Caucasian men treated with highly active antiretroviral therapyMark J Bolland
Department of Medicine, University of Auckland, Auckland, New Zealand
Clin Endocrinol (Oxf) 65:191-7. 2006..We sought to determine whether BMD in HIV-infected men treated with HAART for at least 3 months is different from that in healthy controls, and, if so, what HIV-related factors might explain this finding...
- Evolution of a length polymorphism in the human PER3 gene, a component of the circadian systemNachiket A Nadkarni
Department of Biology University College London, UK
J Biol Rhythms 20:490-9. 2005..We therefore find no evidence for differential or balancing selection in the contemporary pattern of global PER3allele frequencies...