Mark G Thomas

Summary

Affiliation: University College London
Country: UK

Publications

  1. pmc Evidence for an apartheid-like social structure in early Anglo-Saxon England
    Mark G Thomas
    Department of Biology, University College London, Wolfson House, 4 Stephenson Way, London NW1 2HE, UK
    Proc Biol Sci 273:2651-7. 2006
  2. pmc The origins of lactase persistence in Europe
    Yuval Itan
    Research Department of Genetics, Evolution and Environment, University College London, London, United Kingdom
    PLoS Comput Biol 5:e1000491. 2009
  3. ncbi request reprint The flickering genes of the last mammoths
    M G Thomas
    Research Department of Genetics, Evolution and Environment, University College London, Gower Street, London WC1E 6BT, UK
    Mol Ecol 21:3379-81. 2012
  4. pmc Little genetic differentiation as assessed by uniparental markers in the presence of substantial language variation in peoples of the Cross River region of Nigeria
    Krishna R Veeramah
    Centre for Society and Genetics, University of California, Los Angeles, 90095 722, USA
    BMC Evol Biol 10:92. 2010
  5. ncbi request reprint New genetic evidence supports isolation and drift in the Ladin communities of the South Tyrolean Alps but not an ancient origin in the Middle East
    Mark G Thomas
    Department of Biology, University College London, London NW1 2HE, UK
    Eur J Hum Genet 16:124-34. 2008
  6. ncbi request reprint High throughput analysis of 10 microsatellite and 11 diallelic polymorphisms on the human Y-chromosome
    M G Thomas
    The Centre for Genetic Anthropology, The Department of Anthropology, University College London, UK
    Hum Genet 105:577-81. 1999
  7. pmc Molecular instability in the COII-tRNA(Lys) intergenic region of the human mitochondrial genome: multiple origins of the 9-bp deletion and heteroplasmy for expanded repeats
    M G Thomas
    Department of Biological Anthropology, University of Cambridge, UK
    Philos Trans R Soc Lond B Biol Sci 353:955-65. 1998
  8. doi request reprint Multiple rare variants as a cause of a common phenotype: several different lactase persistence associated alleles in a single ethnic group
    Catherine J E Ingram
    Research Department of Genetics, Evolution and Environment, University College London, Wolfson House, 4 Stephenson Way, London, NW1 2HE, UK
    J Mol Evol 69:579-88. 2009
  9. ncbi request reprint A novel polymorphism associated with lactose tolerance in Africa: multiple causes for lactase persistence?
    Catherine J E Ingram
    Department of Biology, Galton Laboratory, University College London, Wolfson House, 4 Stephenson Way, London, UK
    Hum Genet 120:779-88. 2007
  10. ncbi request reprint Y chromosome evidence for Anglo-Saxon mass migration
    Michael E Weale
    The Centre for Genetic Anthropology, Departments of Biology and Anthropology, University College London, University of London, United Kingdom
    Mol Biol Evol 19:1008-21. 2002

Detail Information

Publications52

  1. pmc Evidence for an apartheid-like social structure in early Anglo-Saxon England
    Mark G Thomas
    Department of Biology, University College London, Wolfson House, 4 Stephenson Way, London NW1 2HE, UK
    Proc Biol Sci 273:2651-7. 2006
    ....
  2. pmc The origins of lactase persistence in Europe
    Yuval Itan
    Research Department of Genetics, Evolution and Environment, University College London, London, United Kingdom
    PLoS Comput Biol 5:e1000491. 2009
    ..Our results provide a coherent and spatially explicit picture of the coevolution of lactase persistence and dairying in Europe...
  3. ncbi request reprint The flickering genes of the last mammoths
    M G Thomas
    Research Department of Genetics, Evolution and Environment, University College London, Gower Street, London WC1E 6BT, UK
    Mol Ecol 21:3379-81. 2012
    ..While the ultimate agent of mammoth extinction remains unknown, the work of Nyström et al. (2012). suggests that we should be looking for something sudden, like a rapid change in climate/ecology or perhaps the arrival of humans...
  4. pmc Little genetic differentiation as assessed by uniparental markers in the presence of substantial language variation in peoples of the Cross River region of Nigeria
    Krishna R Veeramah
    Centre for Society and Genetics, University of California, Los Angeles, 90095 722, USA
    BMC Evol Biol 10:92. 2010
    ..In addition the Cross River region was analysed in the context of a larger geographical scale by comparison to bordering Igbo speaking groups as well as neighbouring Cameroon populations and more distant Ghanaian communities...
  5. ncbi request reprint New genetic evidence supports isolation and drift in the Ladin communities of the South Tyrolean Alps but not an ancient origin in the Middle East
    Mark G Thomas
    Department of Biology, University College London, London NW1 2HE, UK
    Eur J Hum Genet 16:124-34. 2008
    ....
  6. ncbi request reprint High throughput analysis of 10 microsatellite and 11 diallelic polymorphisms on the human Y-chromosome
    M G Thomas
    The Centre for Genetic Anthropology, The Department of Anthropology, University College London, UK
    Hum Genet 105:577-81. 1999
    ..The method requires only four PCRs and four GeneScan runs per sample and is relatively insensitive to sample DNA concentration...
  7. pmc Molecular instability in the COII-tRNA(Lys) intergenic region of the human mitochondrial genome: multiple origins of the 9-bp deletion and heteroplasmy for expanded repeats
    M G Thomas
    Department of Biological Anthropology, University of Cambridge, UK
    Philos Trans R Soc Lond B Biol Sci 353:955-65. 1998
    ..From this we conclude that drift in the germ-line lineage is a main factor in the maintenance or loss of heteroplasmy...
  8. doi request reprint Multiple rare variants as a cause of a common phenotype: several different lactase persistence associated alleles in a single ethnic group
    Catherine J E Ingram
    Research Department of Genetics, Evolution and Environment, University College London, Wolfson House, 4 Stephenson Way, London, NW1 2HE, UK
    J Mol Evol 69:579-88. 2009
    ..This contrasts with the well-documented observation that positive selection decreases diversity by driving up the frequency of a single advantageous allele, and has implications for association studies...
  9. ncbi request reprint A novel polymorphism associated with lactose tolerance in Africa: multiple causes for lactase persistence?
    Catherine J E Ingram
    Department of Biology, Galton Laboratory, University College London, Wolfson House, 4 Stephenson Way, London, UK
    Hum Genet 120:779-88. 2007
    ..This study reveals the complexity of this phenotypic polymorphism and highlights the limitations of C-13910T as a diagnostic test for lactase persistence status, at least for people with non-European ancestry...
  10. ncbi request reprint Y chromosome evidence for Anglo-Saxon mass migration
    Michael E Weale
    The Centre for Genetic Anthropology, Departments of Biology and Anthropology, University College London, University of London, United Kingdom
    Mol Biol Evol 19:1008-21. 2002
    ....
  11. doi request reprint Lactose digestion and the evolutionary genetics of lactase persistence
    Catherine J E Ingram
    Department of Genetics Evolution and Environment, University College London, London, UK
    Hum Genet 124:579-91. 2009
    ....
  12. pmc A worldwide correlation of lactase persistence phenotype and genotypes
    Yuval Itan
    Research Department of Genetics, Evolution and Environment, University College London, London WC1E 6BT, UK
    BMC Evol Biol 10:36. 2010
    ....
  13. ncbi request reprint Diet and the frequency of the alanine:glyoxylate aminotransferase Pro11Leu polymorphism in different human populations
    Elizabeth F Caldwell
    Department of Biology, University College London, Gower Street, London, WC1E 6BT, UK
    Hum Genet 115:504-9. 2004
    ....
  14. pmc Ethiopian genetic diversity reveals linguistic stratification and complex influences on the Ethiopian gene pool
    Luca Pagani
    Division of Biological Anthropology, University of Cambridge, UK
    Am J Hum Genet 91:83-96. 2012
    ..Linkage-disequilibrium decay with genomic distance was less rapid in both the whole genome and the African component than in southern African samples, suggesting a less ancient history for Ethiopian populations...
  15. pmc Evolution of lactase persistence: an example of human niche construction
    Pascale Gerbault
    Research Department of Genetics, Evolution and Environment, University College London, Wolfson House, 4 Stephenson Way, London NW1 2HE, UK
    Philos Trans R Soc Lond B Biol Sci 366:863-77. 2011
    ..These studies illustrate how genetic and archaeological information can be integrated to bring new insights to the origins and spread of lactase persistence. Finally, we discuss possible improvements to these models...
  16. doi request reprint Late Pleistocene demography and the appearance of modern human behavior
    Adam Powell
    Research Department of Genetics, Evolution, and Environment, University College London, Wolfson House, 4 Stephenson Way, London NW1 2HE, UK
    Science 324:1298-301. 2009
    ..Demographic factors can thus explain geographic variation in the timing of the first appearance of modern behavior without invoking increased cognitive capacity...
  17. pmc The potentially deleterious functional variant flavin-containing monooxygenase 2*1 is at high frequency throughout sub-Saharan Africa
    Krishna R Veeramah
    The Centre for Genetic Anthropology, Research Department of Genetics, University College, London, UK
    Pharmacogenet Genomics 18:877-86. 2008
    ..FMO2 may also be involved in the metabolism of drugs that are used to treat diseases that are prevalent in Africa...
  18. pmc The T allele of a single-nucleotide polymorphism 13.9 kb upstream of the lactase gene (LCT) (C-13.9kbT) does not predict or cause the lactase-persistence phenotype in Africans
    Charlotte A Mulcare
    The Centre for Genetic Anthropology TCGA, University College London, London NW1 2HE, United Kingdom
    Am J Hum Genet 74:1102-10. 2004
    ..We also present Y-chromosome data that are consistent with previously reported evidence for a back-migration event into Cameroon, and we comment on the implications for the introgression of the -13.9kb*T allele...
  19. ncbi request reprint A Y chromosome census of the British Isles
    Cristian Capelli
    Department of Biology, University College London, Gower Street, London WC1E 6BT, United Kingdom
    Curr Biol 13:979-84. 2003
    ....
  20. doi request reprint Herders of Indian and European cattle share their predominant allele for lactase persistence
    Irene Gallego Romero
    Department of Biological Anthropology, Leverhulme Centre for Human Evolutionary Studies, University of Cambridge, Cambridge, United Kingdom
    Mol Biol Evol 29:249-60. 2012
    ..We confirm that the mutation is identical by descent to the European allele and is associated with the same>1 Mb extended haplotype in both populations...
  21. doi request reprint CYP1A2 is more variable than previously thought: a genomic biography of the gene behind the human drug-metabolizing enzyme
    Sarah L Browning
    The Centre for Genetic Anthropology, University College London, London, UK
    Pharmacogenet Genomics 20:647-64. 2010
    ....
  22. doi request reprint Prevalence of clinically relevant UGT1A alleles and haplotypes in African populations
    Laura J Horsfall
    Department of Genetics, Evolution and Environment, University College London, Wolfson House, UK
    Ann Hum Genet 75:236-46. 2011
    ....
  23. pmc Y-chromosome evidence for differing ancient demographic histories in the Americas
    Maria Catira Bortolini
    Department of Biology, University College, London, United Kingdom
    Am J Hum Genet 73:524-39. 2003
    ..Age estimates based on Y-chromosome microsatellite diversity place the initial settlement of the American continent at approximately 14,000 years ago, in relative agreement with the age of well-established archaeological evidence...
  24. pmc The frequency of an IL-18-associated haplotype in Africans
    Simon R Thompson
    UCL Centre for Cardiovascular Genetics, Rayne Institute, London, UK
    Eur J Hum Genet 21:465-8. 2013
    ..Potentially protective variants may, as a consequence, be found at low frequency in African individuals and may confer a difference in disease risk...
  25. pmc Genetic evidence for different male and female roles during cultural transitions in the British Isles
    J F Wilson
    Galton Laboratory, Department of Biology, University College London, Wolfson House, 4 Stephenson Way, London NW1 2HE, United Kingdom
    Proc Natl Acad Sci U S A 98:5078-83. 2001
    ..In contrast, patterns of mtDNA and X-chromosome variation indicate that one or more of these pre-Anglo-Saxon cultural revolutions had a major effect on the maternal genetic heritage of the British Isles...
  26. pmc Founding mothers of Jewish communities: geographically separated Jewish groups were independently founded by very few female ancestors
    Mark G Thomas
    Departments of Biology and Anthropology, The Centre for Genetic Anthropology, University College London, Gower Street, London WC1E 6BT, UK
    Am J Hum Genet 70:1411-20. 2002
    ....
  27. ncbi request reprint High-throughput analysis of informative CYP2D6 compound haplotypes
    Benjamin Fletcher
    The Centre for Genetic Anthropology, Department of Biology and Department of Anthropology, University College London, UK
    Genomics 81:166-74. 2003
    ..1 using microsatellite variation, and (3) generation of compound haplotypes for investigating the evolution of CYP2D6 variation. We also report compound haplotype frequencies for an Ashkenazi Jewish and a British sample...
  28. pmc Rare deep-rooting Y chromosome lineages in humans: lessons for phylogeography
    Michael E Weale
    The Centre for Genetic Anthropology, Department of Biology, University College, London WC1E 6BT, United Kingdom
    Genetics 165:229-34. 2003
    ..We discuss the problems presented by rare deep-rooting lineages for Y chromosome phylogeography...
  29. pmc Molecular diversity and population structure at the Cytochrome P450 3A5 gene in Africa
    Ripudaman K Bains
    Research Department of Genetics, Evolution and Environment, University College London, Darwin Building, Gower Street, London, WC1E 6BT, UK
    BMC Genet 14:34. 2013
    ..Finally, we examined a hypothesis that CYP3A5 is important in salt retention adaptation by performing correlations with ecological data relating to aridity for the present day, 10,000 and 50,000 years ago...
  30. doi request reprint Detecting gene duplications in the human lineage
    Yuval Itan
    Research Department of Genetics, Evolution and Environment, University College London, UK
    Ann Hum Genet 74:555-65. 2010
    ..In this study, we have developed a set of bioinformatic tools to overcome a number of the conceptual problems that are prevalent in previous studies and have collected a reliable and representative set of human inparalogues...
  31. ncbi request reprint Presence of a newly described human DNA virus (TTV) in patients with liver disease
    N V Naoumov
    Institute of Hepatology, Department of Medicine, University College London Medical School, UK
    Lancet 352:195-7. 1998
    ..We investigated the presence of this virus in patients with liver disease in the UK to find out whether TTV infection is associated with liver damage...
  32. ncbi request reprint Armenian Y chromosome haplotypes reveal strong regional structure within a single ethno-national group
    M E Weale
    Centre for Genetic Anthropology, Departments of Biology and Anthropology, University College London, University of London, Darwin Bdg, Gower St, London WC1E 6BT, UK
    Hum Genet 109:659-74. 2001
    ....
  33. doi request reprint AIP mutation in pituitary adenomas in the 18th century and today
    Harvinder S Chahal
    Department of Endocrinology, Barts and the London School of Medicine, Queen Mary University of London, London, United Kingdom
    N Engl J Med 364:43-50. 2011
    ..Using coalescent theory, we infer that these persons share a common ancestor who lived about 57 to 66 generations earlier...
  34. pmc Regional population collapse followed initial agriculture booms in mid-Holocene Europe
    Stephen Shennan
    Institute of Archaeology, University College London, 31 34 Gordon Square, London WC1H 0PY, UK
    Nat Commun 4:2486. 2013
    ..However, we find no evidence to support a relationship. Our results thus suggest that the demographic patterns may have arisen from endogenous causes, although this remains speculative. ..
  35. pmc Evaluating bacterial pathogen DNA preservation in museum osteological collections
    Ian Barnes
    Department of Biology, University College London, Gower Street, London WC1E 6BT, UK
    Proc Biol Sci 273:645-53. 2006
    ....
  36. ncbi request reprint Population genetic structure of variable drug response
    J F Wilson
    Galton Laboratory, Department of Biology, University College London, London, UK
    Nat Genet 29:265-9. 2001
    ..Our comparison of drug-metabolizing profiles across the inferred clusters establishes a framework for assessing the appropriate level of resolution in relating genetic structure to drug response...
  37. ncbi request reprint The phylogenetic position of the 'giant deer' Megaloceros giganteus
    A M Lister
    Department of Biology, University College London, London WC1E 6BT, UK
    Nature 438:850-3. 2005
    ..Our results include the successful extraction and sequencing of DNA from this extinct species, and highlight the value of a joint molecular and morphological approach...
  38. doi request reprint How long have adult humans been consuming milk?
    Pascale Gerbault
    Research Department of Genetics, Evolution and Environment, University College London, London, WC1E 6BT, UK
    IUBMB Life 65:983-90. 2013
    ..We review here the archaeological and genetic evidence available that have contributed to a better understanding of the gene-culture co-evolution of LP and dairying...
  39. ncbi request reprint Population structure in the Mediterranean basin: a Y chromosome perspective
    C Capelli
    Department of Biology, University College of London, London, UK
    Ann Hum Genet 70:207-25. 2006
    ..In particular, Near Eastern samples tend to separate according to the presence of Arab Y chromosome lineages, suggesting that the Arab expansion played a major role in shaping the current genetic structuring within the Fertile Crescent...
  40. ncbi request reprint Staying out in the cold: glacial refugia and mitochondrial DNA phylogeography in ancient European brown bears
    Cristina E Valdiosera
    Centro Mixto UCM ISCIII de Evolución y Comportamiento Humanos, c Sinesio Delgado 4 Pabellon 14, 28029 Madrid, Spain
    Mol Ecol 16:5140-8. 2007
    ..We propose continuous gene flow across southern Europe, from which brown bear populations expanded after the last glaciation...
  41. pmc Excavating past population structures by surname-based sampling: the genetic legacy of the Vikings in northwest England
    Georgina R Bowden
    Department of Genetics, University of Leicester, Leicester, United Kingdom
    Mol Biol Evol 25:301-9. 2008
    ....
  42. pmc Mitochondrial DNA analysis shows a Near Eastern Neolithic origin for domestic cattle and no indication of domestication of European aurochs
    Ceiridwen J Edwards
    Smurfit Institute of Genetics, Trinity College, Dublin 2, Ireland
    Proc Biol Sci 274:1377-85. 2007
    ..During the period of coexistence, it appears that domestic cattle were kept separate from wild aurochs and introgression was extremely rare...
  43. pmc Multiple origins of Ashkenazi Levites: Y chromosome evidence for both Near Eastern and European ancestries
    Doron M Behar
    Bruce Rappaport Faculty of Medicine and Research Institute, Technion and Rambam Medical Center, Haifa, Israel
    Am J Hum Genet 73:768-79. 2003
    ....
  44. pmc Normophosphatemic familial tumoral calcinosis is caused by deleterious mutations in SAMD9, encoding a TNF-alpha responsive protein
    Ilana Chefetz
    Laboratory of Molecular Dermatology and Department of Dermatology, Rambam Health Care Campus, Haifa, Israel
    J Invest Dermatol 128:1423-9. 2008
    ..These data link NFTC and SAMD9 to the TNF-alpha signaling pathway, suggesting a role for this system in the regulation of extra-osseous calcification...
  45. pmc Surprising migration and population size dynamics in ancient Iberian brown bears (Ursus arctos)
    Cristina E Valdiosera
    Centro Mixto, Universidad Complutense de Madrid Instituto de Salud Carlos III de Evolución y Comportamiento Humanos, c Sinesio Delgado 4 Pabellon 14, 28029 Madrid, Spain
    Proc Natl Acad Sci U S A 105:5123-8. 2008
    ..Thus, the current situation is highly unusual and the population may in fact be isolated for the first time in its history...
  46. ncbi request reprint Genetic structure and extinction of the woolly mammoth, Mammuthus primigenius
    Ian Barnes
    School of Biological Sciences, Royal Holloway, University of London, Egham, Surrey TW20 0EX, United Kingdom
    Curr Biol 17:1072-5. 2007
    ..The most marked change in diversity at this time is the loss of one of two major mitochondrial lineages...
  47. doi request reprint Effects of intravenous zoledronate on bone turnover and BMD persist for at least 24 months
    Mark J Bolland
    Department of Medicine, University of Auckland, Auckland, New Zealand
    J Bone Miner Res 23:1304-8. 2008
    ..Randomized trials that address this issue should be performed...
  48. ncbi request reprint Skin infections of the limbs of Polynesian children
    Mark G Thomas
    N Z Med J 117:U1059. 2004
  49. pmc A new time-scale for ray-finned fish evolution
    Imogen A Hurley
    Department of Organismal Biology and Anatomy, University of Chicago, Chicago, IL 60637, USA
    Proc Biol Sci 274:489-98. 2007
    ..While the date estimate of this event overlaps the probable range of the teleost stem group, a correlation between the genome duplication and the large-scale pattern of actinopterygian phylogeny remains elusive...
  50. ncbi request reprint Tuberculosis in New Zealand: poverty casts a long shadow
    Mark G Thomas
    N Z Med J 119:U2267. 2006
  51. ncbi request reprint Bone mineral density is not reduced in HIV-infected Caucasian men treated with highly active antiretroviral therapy
    Mark J Bolland
    Department of Medicine, University of Auckland, Auckland, New Zealand
    Clin Endocrinol (Oxf) 65:191-7. 2006
    ..We sought to determine whether BMD in HIV-infected men treated with HAART for at least 3 months is different from that in healthy controls, and, if so, what HIV-related factors might explain this finding...
  52. ncbi request reprint Evolution of a length polymorphism in the human PER3 gene, a component of the circadian system
    Nachiket A Nadkarni
    Department of Biology University College London, UK
    J Biol Rhythms 20:490-9. 2005
    ..We therefore find no evidence for differential or balancing selection in the contemporary pattern of global PER3allele frequencies...