Gavin H Thomas

Summary

Affiliation: University of York
Country: UK

Publications

  1. ncbi Evolutionary diversification of an ancient gene family (rhs) through C-terminal displacement
    Andrew P Jackson
    The Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridge, CB10 1SA, UK
    BMC Genomics 10:584. 2009
  2. ncbi A fragile metabolic network adapted for cooperation in the symbiotic bacterium Buchnera aphidicola
    Gavin H Thomas
    Department of Biology, University of York, PO Box 373, York, YO10 5YW, UK
    BMC Syst Biol 3:24. 2009
  3. ncbi Homes for the orphans: utilization of multiple substrate-binding proteins by ABC transporters
    Gavin H Thomas
    Department of Biology Area 10, University of York, York YO10 4BG, UK
    Mol Microbiol 75:6-9. 2010
  4. ncbi Furanose-specific sugar transport: characterization of a bacterial galactofuranose-binding protein
    Richard S P Horler
    Department of Biology, University of York, York YO10 5YW, United Kingdom
    J Biol Chem 284:31156-63. 2009
  5. ncbi Compensating stereochemical changes allow murein tripeptide to be accommodated in a conventional peptide-binding protein
    Abbas Maqbool
    Department of Biology Area 10, University of York, York YO10 5YW, United Kingdom
    J Biol Chem 286:31512-21. 2011
  6. ncbi The substrate-binding protein imposes directionality on an electrochemical sodium gradient-driven TRAP transporter
    Christopher Mulligan
    Department of Biology Area 10, University of York, P O Box 373, York YO10 5YW, United Kingdom
    Proc Natl Acad Sci U S A 106:1778-83. 2009
  7. ncbi Characterization of a novel sialic acid transporter of the sodium solute symporter (SSS) family and in vivo comparison with known bacterial sialic acid transporters
    Emmanuele Severi
    Department of Biology, University of York, York, UK
    FEMS Microbiol Lett 304:47-54. 2010
  8. ncbi Tripartite ATP-independent periplasmic transporters: application of a relational database for genome-wide analysis of transporter gene frequency and organization
    Christopher Mulligan
    Department of Biology, University of York, York, UK
    J Mol Microbiol Biotechnol 12:218-26. 2007
  9. ncbi Sialic acid mutarotation is catalyzed by the Escherichia coli beta-propeller protein YjhT
    Emmanuele Severi
    Department of Biology Area 10, York Structural Biology Laboratory, University of York, York YO10 5YW, United Kingdom
    J Biol Chem 283:4841-9. 2008
  10. ncbi Caught in a TRAP: substrate-binding proteins in secondary transport
    Marcus Fischer
    York Structural Biology Laboratory, Department of Chemistry, University of York, York, YO10 5DD, UK
    Trends Microbiol 18:471-8. 2010

Collaborators

Detail Information

Publications23

  1. ncbi Evolutionary diversification of an ancient gene family (rhs) through C-terminal displacement
    Andrew P Jackson
    The Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridge, CB10 1SA, UK
    BMC Genomics 10:584. 2009
    ..coli. By comparing rhs repertoires across the Enterobacteriaceae, this study provides a robust explanation of rhs diversification and evolution, and a mechanistic model of how rhs diversity is gained and lost...
  2. ncbi A fragile metabolic network adapted for cooperation in the symbiotic bacterium Buchnera aphidicola
    Gavin H Thomas
    Department of Biology, University of York, PO Box 373, York, YO10 5YW, UK
    BMC Syst Biol 3:24. 2009
    ..coli genome...
  3. ncbi Homes for the orphans: utilization of multiple substrate-binding proteins by ABC transporters
    Gavin H Thomas
    Department of Biology Area 10, University of York, York YO10 4BG, UK
    Mol Microbiol 75:6-9. 2010
    ..This new finding provides an important piece of in vivo data leading to further insight into how this ubiquitous family of transporters operates...
  4. ncbi Furanose-specific sugar transport: characterization of a bacterial galactofuranose-binding protein
    Richard S P Horler
    Department of Biology, University of York, York YO10 5YW, United Kingdom
    J Biol Chem 284:31156-63. 2009
    ..coli, suggesting that this bacterium has evolved complementary transporters that enable it to use all the available galactose present during carbon limiting conditions...
  5. ncbi Compensating stereochemical changes allow murein tripeptide to be accommodated in a conventional peptide-binding protein
    Abbas Maqbool
    Department of Biology Area 10, University of York, York YO10 5YW, United Kingdom
    J Biol Chem 286:31512-21. 2011
    ....
  6. ncbi The substrate-binding protein imposes directionality on an electrochemical sodium gradient-driven TRAP transporter
    Christopher Mulligan
    Department of Biology Area 10, University of York, P O Box 373, York YO10 5YW, United Kingdom
    Proc Natl Acad Sci U S A 106:1778-83. 2009
    ..Importantly, the binding protein also confers directionality on the transporter, and reversal of sialic acid transport from import to export is only possible in the presence of an excess of unliganded SiaP...
  7. ncbi Characterization of a novel sialic acid transporter of the sodium solute symporter (SSS) family and in vivo comparison with known bacterial sialic acid transporters
    Emmanuele Severi
    Department of Biology, University of York, York, UK
    FEMS Microbiol Lett 304:47-54. 2010
    ....
  8. ncbi Tripartite ATP-independent periplasmic transporters: application of a relational database for genome-wide analysis of transporter gene frequency and organization
    Christopher Mulligan
    Department of Biology, University of York, York, UK
    J Mol Microbiol Biotechnol 12:218-26. 2007
    ..Additionally, we report a number of new organizations of TRAP transporter genes and proteins which suggest the recruitment of TRAP transporter components for use in other biological contexts...
  9. ncbi Sialic acid mutarotation is catalyzed by the Escherichia coli beta-propeller protein YjhT
    Emmanuele Severi
    Department of Biology Area 10, York Structural Biology Laboratory, University of York, York YO10 5YW, United Kingdom
    J Biol Chem 283:4841-9. 2008
    ..We also present data suggesting that the ability to utilize alpha-N-acetylneuraminic acid released from complex sialoconjugates in vivo provides a physiological advantage to bacteria containing YjhT...
  10. ncbi Caught in a TRAP: substrate-binding proteins in secondary transport
    Marcus Fischer
    York Structural Biology Laboratory, Department of Chemistry, University of York, York, YO10 5DD, UK
    Trends Microbiol 18:471-8. 2010
    ..Other SBPs used in secondary transporters are structurally similar to ABC SBPs, demonstrating that multiple families of SBPs have evolved to function with secondary transporters...
  11. ncbi MpaA is a murein-tripeptide-specific zinc carboxypeptidase that functions as part of a catabolic pathway for peptidoglycan-derived peptides in γ-proteobacteria
    Abbas Maqbool
    Department of Biology Area 10, Department of Chemistry, University of York, York YO10 5DD, UK
    Biochem J 448:329-41. 2012
    ....
  12. ncbi Staphyloferrin A as siderophore-component in fluoroquinolone-based Trojan horse antibiotics
    Stephen J Milner
    Department of Chemistry, University of York, Heslington, York YO10 5DD, UK
    Org Biomol Chem 11:3461-8. 2013
    ..The loss of potency observed for the (R)- and (S)-ornithine-based ciprofloxacin conjugates correlates with their reduced inhibitory activity against the target enzyme DNA gyrase...
  13. ncbi The membrane proteins SiaQ and SiaM form an essential stoichiometric complex in the sialic acid tripartite ATP-independent periplasmic (TRAP) transporter SiaPQM (VC1777-1779) from Vibrio cholerae
    Christopher Mulligan
    Department of Biology Area 10, University of York, York YO10 5YW, United Kingdom
    J Biol Chem 287:3598-608. 2012
    ..Using reconstituted proteoliposomes containing particular combinations of the three subunits, we demonstrate biochemically that all three subunits are likely to be essential to form a functional TRAP transporter...
  14. ncbi Tripartite ATP-independent periplasmic (TRAP) transporters in bacteria and archaea
    Christopher Mulligan
    Department of Biology, University of York, York, UK
    FEMS Microbiol Rev 35:68-86. 2011
    ....
  15. ncbi The central role of the host cell in symbiotic nitrogen metabolism
    Sandy J Macdonald
    Department of Biology Area 10, University of York, York, UK
    Proc Biol Sci 279:2965-73. 2012
    ..Host cell-mediated nitrogen recycling may be general among insect symbioses with shared EAA biosynthetic pathways generated by the loss of symbiont genes mediating terminal reactions in EAA synthesis...
  16. ncbi Sialic acid utilization by the soil bacterium Corynebacterium glutamicum
    Nadine Gruteser
    Department of Biology Area 10, University of York, York, UK
    FEMS Microbiol Lett 336:131-8. 2012
    ..The demonstration that a member of the Actinobacteria can transport and catabolize Neu5Ac efficiently suggests that sialic acid metabolism has a physiological role in the soil environment...
  17. ncbi Sialic acid transport in Haemophilus influenzae is essential for lipopolysaccharide sialylation and serum resistance and is dependent on a novel tripartite ATP-independent periplasmic transporter
    Emmanuele Severi
    Department of Biology, University of York, York, YO10 5YW, UK
    Mol Microbiol 58:1173-85. 2005
    ..The inactivation of the SiaPQM TRAP transporter also results in decreased growth of H. influenzae in a chemically defined medium containing Neu5Ac, supporting an additional nutritional role of sialic acid in H. influenzae physiology...
  18. ncbi Synthesis of citrate-ciprofloxacin conjugates
    Siti R Md-Saleh
    Department of Chemistry, University of York, Heslington, York, YO10 5DD, UK
    Bioorg Med Chem Lett 19:1496-8. 2009
    ..Cellular uptake mechanisms were investigated using wild-type and ompF deletion strains of Escherichia coli K-12...
  19. ncbi BuchneraBASE: a post-genomic resource for Buchnera sp. APS
    M Dennis Prickett
    Department of Biology, University of York, York YO10 5YW, UK
    Bioinformatics 22:641-2. 2006
    ..The database is designed to accommodate genome-wide post-genomic datasets that are becoming available for this organism. AVAILABILITY: BuchneraBASE is available at http://www.buchnera.org/...
  20. ncbi Sialic acid utilization by bacterial pathogens
    Emmanuele Severi
    Department of Biology Area 10, University of York, PO Box 373, York YO10 5YW, UK
    Microbiology 153:2817-22. 2007
    ..In this mini-review we will summarize recent findings relating to sialic acid transport, modification of sialic acid by O-acetylation, and the mechanisms of sialic acid-mediated complement resistance...
  21. ncbi EchoLOCATION: an in silico analysis of the subcellular locations of Escherichia coli proteins and comparison with experimentally derived locations
    Richard S P Horler
    Department of Biology Area 10, University of York, York, UK
    Bioinformatics 25:163-6. 2009
    ..From analysis of disagreements between in silico predictions and experimental data, we provide an analysis of protein types where subcellular prediction algorithms are currently not accurate...
  22. ncbi An ATP-binding cassette-type cysteine transporter in Campylobacter jejuni inferred from the structure of an extracytoplasmic solute receptor protein
    Axel Muller
    Structural Biology Laboratory, Department of Chemistry, University of York, York, YO10 5YW, UK
    Mol Microbiol 57:143-55. 2005
    ..These data imply that Cj0982 is the binding protein component of an ABC-type cysteine transporter system and that cysteine uptake is important in the physiology of C. jejuni...
  23. ncbi EchoBASE: an integrated post-genomic database for Escherichia coli
    Raju V Misra
    Department of Biology (Area 10, University of York, PO Box 373, York, YO10 5YW, UK
    Nucleic Acids Res 33:D329-33. 2005
    ..EchoBASE also contains annotated information on 'orphan' enzyme activities from this microbe to aid characterization of the proteins that catalyse these elusive biochemical reactions...