Gavin H Thomas

Summary

Affiliation: University of York
Country: UK

Publications

  1. pmc Evolutionary diversification of an ancient gene family (rhs) through C-terminal displacement
    Andrew P Jackson
    The Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridge, CB10 1SA, UK
    BMC Genomics 10:584. 2009
  2. doi request reprint Homes for the orphans: utilization of multiple substrate-binding proteins by ABC transporters
    Gavin H Thomas
    Department of Biology Area 10, University of York, York YO10 4BG, UK
    Mol Microbiol 75:6-9. 2010
  3. pmc A fragile metabolic network adapted for cooperation in the symbiotic bacterium Buchnera aphidicola
    Gavin H Thomas
    Department of Biology, University of York, PO Box 373, York, YO10 5YW, UK
    BMC Syst Biol 3:24. 2009
  4. pmc Furanose-specific sugar transport: characterization of a bacterial galactofuranose-binding protein
    Richard S P Horler
    Department of Biology, University of York, York YO10 5YW, United Kingdom
    J Biol Chem 284:31156-63. 2009
  5. pmc The substrate-binding protein imposes directionality on an electrochemical sodium gradient-driven TRAP transporter
    Christopher Mulligan
    Department of Biology Area 10, University of York, P O Box 373, York YO10 5YW, United Kingdom
    Proc Natl Acad Sci U S A 106:1778-83. 2009
  6. pmc Compensating stereochemical changes allow murein tripeptide to be accommodated in a conventional peptide-binding protein
    Abbas Maqbool
    Department of Biology Area 10, University of York, York YO10 5YW, United Kingdom
    J Biol Chem 286:31512-21. 2011
  7. doi request reprint Characterization of a novel sialic acid transporter of the sodium solute symporter (SSS) family and in vivo comparison with known bacterial sialic acid transporters
    Emmanuele Severi
    Department of Biology, University of York, York, UK
    FEMS Microbiol Lett 304:47-54. 2010
  8. ncbi request reprint Sialic acid mutarotation is catalyzed by the Escherichia coli beta-propeller protein YjhT
    Emmanuele Severi
    Department of Biology Area 10, York Structural Biology Laboratory, University of York, York YO10 5YW, United Kingdom
    J Biol Chem 283:4841-9. 2008
  9. ncbi request reprint Tripartite ATP-independent periplasmic transporters: application of a relational database for genome-wide analysis of transporter gene frequency and organization
    Christopher Mulligan
    Department of Biology, University of York, York, UK
    J Mol Microbiol Biotechnol 12:218-26. 2007
  10. doi request reprint Staphyloferrin A as siderophore-component in fluoroquinolone-based Trojan horse antibiotics
    Stephen J Milner
    Department of Chemistry, University of York, Heslington, York YO10 5DD, UK
    Org Biomol Chem 11:3461-8. 2013

Collaborators

  • Angela E Douglas
  • Reinhard Kramer
  • David Kelly
  • Richard Moxon
  • Roderick E Hubbard
  • Eric R Geertsma
  • Derek W Hood
  • Mireille Hervé
  • Bert Poolman
  • Anna M Snelling
  • James A Brannigan
  • Dominique Mengin-Lecreulx
  • Emmanuele Severi
  • Christopher Mulligan
  • Richard S P Horler
  • Abbas Maqbool
  • Axel Muller
  • Stephen J Milner
  • Marcus Fischer
  • Anthony J Wilkinson
  • Keith S Wilson
  • Adam P Hopkins
  • Sandy J Macdonald
  • Nadine Gruteser
  • Judith A Hawkhead
  • Kevin G Kerr
  • Anne Routledge
  • Anne Kathrin Duhme-Klair
  • Siti R Md-Saleh
  • Andrew P Jackson
  • Jennifer R Potts
  • Vladimir M Levdikov
  • M Dennis Prickett
  • Raju V Misra
  • Alexandra Seve
  • Kay Marin
  • Calum W Russell
  • George G Lin
  • Andrew P Leech
  • Elena V Blagova
  • Arthur H F Hosie
  • Qian Yi Zhang
  • David C Williamson
  • Emily C Chilvers
  • Peter D Ashton
  • Nikitas Papangelopoulos
  • Julian Parkhill
  • Andrew Butcher
  • Jan P Weber
  • Nicholas R Thomson
  • David Williamson
  • Andrew Leech
  • Matt Page
  • Mark J Fogg
  • Kate Whitfield
  • Elena Blagova
  • Richard Horler
  • Igor I Goryanin
  • Rosie Young
  • Wolfgang Reindl
  • Gaynor Randle
  • Polly Kivlin

Detail Information

Publications24

  1. pmc Evolutionary diversification of an ancient gene family (rhs) through C-terminal displacement
    Andrew P Jackson
    The Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridge, CB10 1SA, UK
    BMC Genomics 10:584. 2009
    ..coli. By comparing rhs repertoires across the Enterobacteriaceae, this study provides a robust explanation of rhs diversification and evolution, and a mechanistic model of how rhs diversity is gained and lost...
  2. doi request reprint Homes for the orphans: utilization of multiple substrate-binding proteins by ABC transporters
    Gavin H Thomas
    Department of Biology Area 10, University of York, York YO10 4BG, UK
    Mol Microbiol 75:6-9. 2010
    ..This new finding provides an important piece of in vivo data leading to further insight into how this ubiquitous family of transporters operates...
  3. pmc A fragile metabolic network adapted for cooperation in the symbiotic bacterium Buchnera aphidicola
    Gavin H Thomas
    Department of Biology, University of York, PO Box 373, York, YO10 5YW, UK
    BMC Syst Biol 3:24. 2009
    ..coli genome...
  4. pmc Furanose-specific sugar transport: characterization of a bacterial galactofuranose-binding protein
    Richard S P Horler
    Department of Biology, University of York, York YO10 5YW, United Kingdom
    J Biol Chem 284:31156-63. 2009
    ..coli, suggesting that this bacterium has evolved complementary transporters that enable it to use all the available galactose present during carbon limiting conditions...
  5. pmc The substrate-binding protein imposes directionality on an electrochemical sodium gradient-driven TRAP transporter
    Christopher Mulligan
    Department of Biology Area 10, University of York, P O Box 373, York YO10 5YW, United Kingdom
    Proc Natl Acad Sci U S A 106:1778-83. 2009
    ..Importantly, the binding protein also confers directionality on the transporter, and reversal of sialic acid transport from import to export is only possible in the presence of an excess of unliganded SiaP...
  6. pmc Compensating stereochemical changes allow murein tripeptide to be accommodated in a conventional peptide-binding protein
    Abbas Maqbool
    Department of Biology Area 10, University of York, York YO10 5YW, United Kingdom
    J Biol Chem 286:31512-21. 2011
    ....
  7. doi request reprint Characterization of a novel sialic acid transporter of the sodium solute symporter (SSS) family and in vivo comparison with known bacterial sialic acid transporters
    Emmanuele Severi
    Department of Biology, University of York, York, UK
    FEMS Microbiol Lett 304:47-54. 2010
    ....
  8. ncbi request reprint Sialic acid mutarotation is catalyzed by the Escherichia coli beta-propeller protein YjhT
    Emmanuele Severi
    Department of Biology Area 10, York Structural Biology Laboratory, University of York, York YO10 5YW, United Kingdom
    J Biol Chem 283:4841-9. 2008
    ..We also present data suggesting that the ability to utilize alpha-N-acetylneuraminic acid released from complex sialoconjugates in vivo provides a physiological advantage to bacteria containing YjhT...
  9. ncbi request reprint Tripartite ATP-independent periplasmic transporters: application of a relational database for genome-wide analysis of transporter gene frequency and organization
    Christopher Mulligan
    Department of Biology, University of York, York, UK
    J Mol Microbiol Biotechnol 12:218-26. 2007
    ..Additionally, we report a number of new organizations of TRAP transporter genes and proteins which suggest the recruitment of TRAP transporter components for use in other biological contexts...
  10. doi request reprint Staphyloferrin A as siderophore-component in fluoroquinolone-based Trojan horse antibiotics
    Stephen J Milner
    Department of Chemistry, University of York, Heslington, York YO10 5DD, UK
    Org Biomol Chem 11:3461-8. 2013
    ..The loss of potency observed for the (R)- and (S)-ornithine-based ciprofloxacin conjugates correlates with their reduced inhibitory activity against the target enzyme DNA gyrase...
  11. doi request reprint Caught in a TRAP: substrate-binding proteins in secondary transport
    Marcus Fischer
    York Structural Biology Laboratory, Department of Chemistry, University of York, York, YO10 5DD, UK
    Trends Microbiol 18:471-8. 2010
    ..Other SBPs used in secondary transporters are structurally similar to ABC SBPs, demonstrating that multiple families of SBPs have evolved to function with secondary transporters...
  12. doi request reprint MpaA is a murein-tripeptide-specific zinc carboxypeptidase that functions as part of a catabolic pathway for peptidoglycan-derived peptides in γ-proteobacteria
    Abbas Maqbool
    Department of Biology Area 10, Department of Chemistry, University of York, York YO10 5DD, UK
    Biochem J 448:329-41. 2012
    ....
  13. pmc The membrane proteins SiaQ and SiaM form an essential stoichiometric complex in the sialic acid tripartite ATP-independent periplasmic (TRAP) transporter SiaPQM (VC1777-1779) from Vibrio cholerae
    Christopher Mulligan
    Department of Biology Area 10, University of York, York YO10 5YW, United Kingdom
    J Biol Chem 287:3598-608. 2012
    ..Using reconstituted proteoliposomes containing particular combinations of the three subunits, we demonstrate biochemically that all three subunits are likely to be essential to form a functional TRAP transporter...
  14. doi request reprint Tripartite ATP-independent periplasmic (TRAP) transporters in bacteria and archaea
    Christopher Mulligan
    Department of Biology, University of York, York, UK
    FEMS Microbiol Rev 35:68-86. 2011
    ....
  15. pmc The central role of the host cell in symbiotic nitrogen metabolism
    Sandy J Macdonald
    Department of Biology Area 10, University of York, York, UK
    Proc Biol Sci 279:2965-73. 2012
    ..Host cell-mediated nitrogen recycling may be general among insect symbioses with shared EAA biosynthetic pathways generated by the loss of symbiont genes mediating terminal reactions in EAA synthesis...
  16. doi request reprint Sialic acid utilization by the soil bacterium Corynebacterium glutamicum
    Nadine Gruteser
    Department of Biology Area 10, University of York, York, UK
    FEMS Microbiol Lett 336:131-8. 2012
    ..The demonstration that a member of the Actinobacteria can transport and catabolize Neu5Ac efficiently suggests that sialic acid metabolism has a physiological role in the soil environment...
  17. ncbi request reprint Sialic acid transport in Haemophilus influenzae is essential for lipopolysaccharide sialylation and serum resistance and is dependent on a novel tripartite ATP-independent periplasmic transporter
    Emmanuele Severi
    Department of Biology, University of York, York, YO10 5YW, UK
    Mol Microbiol 58:1173-85. 2005
    ..The inactivation of the SiaPQM TRAP transporter also results in decreased growth of H. influenzae in a chemically defined medium containing Neu5Ac, supporting an additional nutritional role of sialic acid in H. influenzae physiology...
  18. doi request reprint Synthesis of citrate-ciprofloxacin conjugates
    Siti R Md-Saleh
    Department of Chemistry, University of York, Heslington, York, YO10 5DD, UK
    Bioorg Med Chem Lett 19:1496-8. 2009
    ..Cellular uptake mechanisms were investigated using wild-type and ompF deletion strains of Escherichia coli K-12...
  19. ncbi request reprint Sialic acid utilization by bacterial pathogens
    Emmanuele Severi
    Department of Biology Area 10, University of York, PO Box 373, York YO10 5YW, UK
    Microbiology 153:2817-22. 2007
    ..In this mini-review we will summarize recent findings relating to sialic acid transport, modification of sialic acid by O-acetylation, and the mechanisms of sialic acid-mediated complement resistance...
  20. ncbi request reprint BuchneraBASE: a post-genomic resource for Buchnera sp. APS
    M Dennis Prickett
    Department of Biology, University of York, York YO10 5YW, UK
    Bioinformatics 22:641-2. 2006
    ..The database is designed to accommodate genome-wide post-genomic datasets that are becoming available for this organism...
  21. doi request reprint Transport and catabolism of the sialic acids N-glycolylneuraminic acid and 3-keto-3-deoxy-D-glycero-D-galactonononic acid by Escherichia coli K-12
    Adam P Hopkins
    Department of Biology, University of York, Heslington, York, UK
    FEMS Microbiol Lett 347:14-22. 2013
    ..Typhimurium, suggesting that the ability to use Neu5Gc and KDN in addition to Neu5Ac is present in a number of human pathogens...
  22. doi request reprint EchoLOCATION: an in silico analysis of the subcellular locations of Escherichia coli proteins and comparison with experimentally derived locations
    Richard S P Horler
    Department of Biology Area 10, University of York, York, UK
    Bioinformatics 25:163-6. 2009
    ..From analysis of disagreements between in silico predictions and experimental data, we provide an analysis of protein types where subcellular prediction algorithms are currently not accurate...
  23. ncbi request reprint An ATP-binding cassette-type cysteine transporter in Campylobacter jejuni inferred from the structure of an extracytoplasmic solute receptor protein
    Axel Muller
    Structural Biology Laboratory, Department of Chemistry, University of York, York, YO10 5YW, UK
    Mol Microbiol 57:143-55. 2005
    ..These data imply that Cj0982 is the binding protein component of an ABC-type cysteine transporter system and that cysteine uptake is important in the physiology of C. jejuni...
  24. pmc EchoBASE: an integrated post-genomic database for Escherichia coli
    Raju V Misra
    Department of Biology Area 10, University of York, PO Box 373, York, YO10 5YW, UK
    Nucleic Acids Res 33:D329-33. 2005
    ..EchoBASE also contains annotated information on 'orphan' enzyme activities from this microbe to aid characterization of the proteins that catalyse these elusive biochemical reactions...