A J Thomas

Summary

Affiliation: University of Newcastle
Country: UK

Publications

  1. doi request reprint Depression and cognition in older adults
    Alan J Thomas
    Institute for Ageing and Health, Newcastle University, Newcastle, UK
    Curr Opin Psychiatry 21:8-13. 2008
  2. ncbi request reprint Increase in interleukin-1beta in late-life depression
    Alan J Thomas
    School of Neurology, Neurobiology and Psychiatry and the Institute for Ageing and Health, University of Newcastle upon Tyne, UK
    Am J Psychiatry 162:175-7. 2005
  3. ncbi request reprint Distribution of amyloid beta 42 in relation to the cerebral microvasculature in an elderly cohort with Alzheimer's disease
    A J Thomas
    Wolfson Research Centre, Newcastle General Hospital, Newcastle upon Tyne, United Kingdom
    Ann N Y Acad Sci 903:83-8. 2000
  4. doi request reprint A comparison of neurocognitive impairment in younger and older adults with major depression
    A J Thomas
    Institute for Ageing and Health, Newcastle University, UK
    Psychol Med 39:725-33. 2009
  5. ncbi request reprint Soluble cell adhesion molecules in late-life depression
    Alan J Thomas
    School of Neurology, Neurobiology and Psychiatry, University of Newcastle upon Tyne, U K
    Int Psychogeriatr 19:914-20. 2007
  6. ncbi request reprint A study of the serotonin transporter in the prefrontal cortex in late-life depression and Alzheimer's disease with and without depression
    A J Thomas
    School of Neurology, Neurobiology and Psychiatry, University of Newcastle upon Tyne, Newcastle upon Tyne, UK
    Neuropathol Appl Neurobiol 32:296-303. 2006
  7. ncbi request reprint Depression and vascular disease: what is the relationship?
    Alan J Thomas
    Wolfson Research Centre, Department of Psychiatry and Institute for Ageing and Health, University of Newcastle upon Tyne, Newcastle upon Tyne NE4 6BE, UK
    J Affect Disord 79:81-95. 2004
  8. ncbi request reprint A neuropathological study of periventricular white matter hyperintensities in major depression
    Alan J Thomas
    Department of Psychiatry and Institute for Ageing and Health, University of Newcastle upon Tyne, Newcastle upon Tyne NE4 6BE, UK
    J Affect Disord 76:49-54. 2003
  9. pmc A neuropathological study of vascular factors in late-life depression
    A J Thomas
    Department of Psychiatry, University of Newcastle upon Tyne, UK
    J Neurol Neurosurg Psychiatry 70:83-7. 2001
  10. ncbi request reprint Neuropathological evidence for ischemia in the white matter of the dorsolateral prefrontal cortex in late-life depression
    Alan J Thomas
    Department of Psychiatry and Institute for Ageing and Health, University of Newcastle upon Tyne, UK
    Int J Geriatr Psychiatry 18:7-13. 2003

Detail Information

Publications25

  1. doi request reprint Depression and cognition in older adults
    Alan J Thomas
    Institute for Ageing and Health, Newcastle University, Newcastle, UK
    Curr Opin Psychiatry 21:8-13. 2008
    ..This review identifies and clarifies recent progress in this rapidly developing research area...
  2. ncbi request reprint Increase in interleukin-1beta in late-life depression
    Alan J Thomas
    School of Neurology, Neurobiology and Psychiatry and the Institute for Ageing and Health, University of Newcastle upon Tyne, UK
    Am J Psychiatry 162:175-7. 2005
    ..The authors tested the hypothesis that levels of cytokine interleukin-1beta (IL-1beta) would be higher in subjects with late-life major depression...
  3. ncbi request reprint Distribution of amyloid beta 42 in relation to the cerebral microvasculature in an elderly cohort with Alzheimer's disease
    A J Thomas
    Wolfson Research Centre, Newcastle General Hospital, Newcastle upon Tyne, United Kingdom
    Ann N Y Acad Sci 903:83-8. 2000
    ..These observations suggest that high proportions of cortical microvessels are associated with A beta 42, which may affect microvascular function...
  4. doi request reprint A comparison of neurocognitive impairment in younger and older adults with major depression
    A J Thomas
    Institute for Ageing and Health, Newcastle University, UK
    Psychol Med 39:725-33. 2009
    ..We hypothesized that ageing alone would not fully explain the increased neurocognitive impairment in late-life depression but that differences in the illness explain the greater decrements in memory and executive function...
  5. ncbi request reprint Soluble cell adhesion molecules in late-life depression
    Alan J Thomas
    School of Neurology, Neurobiology and Psychiatry, University of Newcastle upon Tyne, U K
    Int Psychogeriatr 19:914-20. 2007
    ..We hypothesized that soluble intercellular adhesion molecule-1 (sICAM-1) and soluble vascular cell adhesion molecule-1 (sVCAM-1) would be increased in late-life major depression...
  6. ncbi request reprint A study of the serotonin transporter in the prefrontal cortex in late-life depression and Alzheimer's disease with and without depression
    A J Thomas
    School of Neurology, Neurobiology and Psychiatry, University of Newcastle upon Tyne, Newcastle upon Tyne, UK
    Neuropathol Appl Neurobiol 32:296-303. 2006
    ..In a group of subjects more typical of late-life depression we did not identify any alterations in SERT density...
  7. ncbi request reprint Depression and vascular disease: what is the relationship?
    Alan J Thomas
    Wolfson Research Centre, Department of Psychiatry and Institute for Ageing and Health, University of Newcastle upon Tyne, Newcastle upon Tyne NE4 6BE, UK
    J Affect Disord 79:81-95. 2004
    ..the 'vascular depression' hypothesis proposes that vascular disease predisposes to, precipitates or perpetuates depression, and this proposal has stimulated further research into the relationship of depression to vascular disease...
  8. ncbi request reprint A neuropathological study of periventricular white matter hyperintensities in major depression
    Alan J Thomas
    Department of Psychiatry and Institute for Ageing and Health, University of Newcastle upon Tyne, Newcastle upon Tyne NE4 6BE, UK
    J Affect Disord 76:49-54. 2003
    ..We hypothesised that different pathologies would be associated with the same MRI appearance of PVH and that such causes would be similar in depressed and control subjects...
  9. pmc A neuropathological study of vascular factors in late-life depression
    A J Thomas
    Department of Psychiatry, University of Newcastle upon Tyne, UK
    J Neurol Neurosurg Psychiatry 70:83-7. 2001
    ..Postmortem tissue was investigated to determine whether late life depression was associated with atheromatous change in large and medium vessels and microvascular disease in the brain...
  10. ncbi request reprint Neuropathological evidence for ischemia in the white matter of the dorsolateral prefrontal cortex in late-life depression
    Alan J Thomas
    Department of Psychiatry and Institute for Ageing and Health, University of Newcastle upon Tyne, UK
    Int J Geriatr Psychiatry 18:7-13. 2003
    ..These lesions are probably vascular in origin and proposed sites for vascular damage include the dorsolateral prefrontal cortex (DLPFC) and anterior cingulate cortex (ACC)...
  11. ncbi request reprint Pathologies and pathological mechanisms for white matter hyperintensities in depression
    Alan J Thomas
    Department of Psychiatry and Institute for Ageing and Health, University of Newcastle upon Tyne, Newcastle upon Tyne NE4 6BE, United Kingdom
    Ann N Y Acad Sci 977:333-9. 2002
    ..However, since large vessel and small vessel disease were not associated with WMH, our findings suggest hypotensive disease might be an important and unrecognized mechanism underlying WMH in late-life depression...
  12. ncbi request reprint Ischemic basis for deep white matter hyperintensities in major depression: a neuropathological study
    Alan J Thomas
    Department of Psychiatry, Institute for Ageing and Health, University of Newcastle upon Tyne, Newcastle General Hospital, Newcastle upon Tyne NE4 6BE, England
    Arch Gen Psychiatry 59:785-92. 2002
    ..We investigated the neuropathological basis of these lesions in depression, hypothesizing that they would be more frequently ischemic in origin in depressed subjects...
  13. ncbi request reprint Cell adhesion molecule expression in the dorsolateral prefrontal cortex and anterior cingulate cortex in major depression in the elderly
    Alan J Thomas
    Wolfson Research Centre, Institute for Ageing and Health, Newcastle General Hospital, Newcastle upon Tyne, UK
    Br J Psychiatry 181:129-34. 2002
    ..Neuroimaging studies have demonstrated changes in the dorsolateral prefrontal cortex (DLPFC) and anterior cingulate cortex (ACC) in major depression...
  14. ncbi request reprint Elevation in late-life depression of intercellular adhesion molecule-1 expression in the dorsolateral prefrontal cortex
    A J Thomas
    Department of Psychiatry, University of Newcastle upon Tyne, UK
    Am J Psychiatry 157:1682-4. 2000
    ..The authors investigated this association by determining whether intercellular adhesion molecule-1 (ICAM-1), a marker of ischemia-induced inflammation, is elevated in the dorsolateral prefrontal cortex in depression...
  15. doi request reprint A study of orthostatic hypotension in late-life depression
    Jonathan Richardson
    Institute for Ageing and Health, Newcastle University, England, UK
    Am J Geriatr Psychiatry 17:996-9. 2009
    ..Studies examining vascular risk factors in depression report conflicting evidence but have not assessed orthostatic hypotension, a recently recognized risk factor for white matter hyperintensities...
  16. doi request reprint The pattern and course of cognitive impairment in late-life depression
    S Kohler
    Wolfson Research Centre, Institute for Ageing and Health, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne NE4 5PL, UK
    Psychol Med 40:591-602. 2010
    ..To investigate this, we followed the pattern of cognitive impairments over time and examined the effects of current mood, remission status, age of depression onset and antidepressant (AD) treatment on these deficits...
  17. doi request reprint Morphometric analysis of neuronal and glial cell pathology in the dorsolateral prefrontal cortex in late-life depression
    Ahmad Khundakar
    Cbiol MiBiol, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne NE4 5PL, UK
    Br J Psychiatry 195:163-9. 2009
    ..Neuroimaging and morphometric studies have identified abnormalities in the dorsolateral prefrontal cortex...
  18. doi request reprint Morphometric changes in early- and late-life major depressive disorder: evidence from postmortem studies
    Ahmad A Khundakar
    Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK
    Int Psychogeriatr 21:844-54. 2009
    ..It has therefore been hypothesized that different morphometric and pathological changes may be associated with MDD, depending on age...
  19. doi request reprint Functional connectivity in late-life depression using resting-state functional magnetic resonance imaging
    Eva R Kenny
    Newcastle Magnetic Resonance Centre, Newcastle University, Newcastle upon Tyne, UK
    Am J Geriatr Psychiatry 18:643-51. 2010
    ..To investigate whether there are differences in brain connectivity in late-life depression (LLD) and nondepressed subjects using the left and right heads of caudate nuclei (hCN) as the seed regions...
  20. doi request reprint A morphometric examination of neuronal and glial cell pathology in the orbitofrontal cortex in late-life depression
    Ahmad Khundakar
    Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK
    Int Psychogeriatr 23:132-40. 2011
    ..This study aims to examine morphometrically glial cell and neuronal density and neuronal volume in the orbitofrontal cortex of late-life major depression patients...
  21. ncbi request reprint Neuropathological study of the dorsal raphe nuclei in late-life depression and Alzheimer's disease with and without depression
    Michelle Hendricksen
    School of Neurology, Neurobiology and Psychiatry, University of Newcastle upon Tyne, Newcastle upon Tyne, UK
    Am J Psychiatry 161:1096-102. 2004
    ....
  22. ncbi request reprint Elevation of cell adhesion molecule immunoreactivity in the anterior cingulate cortex in bipolar disorder
    Alan J Thomas
    School of Neurology, Neurobiology and Psychiatry, University of Newcastle upon Tyne, UK
    Biol Psychiatry 55:652-5. 2004
    ..Neuroimaging reports of increases in signal hyperintensities in white and deep gray matter and other work indicate that there might be an inflammatory response in affective disorders...
  23. doi request reprint White matter hyperintensities, cortisol levels, brain atrophy and continuing cognitive deficits in late-life depression
    Sebastian Kohler
    Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK
    Br J Psychiatry 196:143-9. 2010
    ..Cerebrovascular changes and glucocorticoid mediated hippocampal atrophy are considered relevant for depression-related cognitive deficits, forming putative treatment targets...
  24. ncbi request reprint A comparison of the efficacy of donepezil in Parkinson's disease with dementia and dementia with Lewy bodies
    Alan J Thomas
    Institute for Ageing and Health, University of Newcastle upon Tyne, Wolfson Research Centre, Newcastle General Hospital, Newcastle upon Tyne, UK
    Int J Geriatr Psychiatry 20:938-44. 2005
    ..Parkinson's disease with dementia (PDD) and dementia with Lewy bodies (DLB) overlap in phenomenology and neurochemical deficits. We hypothesised they would not differ in their response to the cholinesterase inhibitor donepezil...
  25. doi request reprint Relationship of orthostatic blood pressure to white matter hyperintensities and subcortical volumes in late-life depression
    Sean J Colloby
    Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, UK
    Br J Psychiatry 199:404-10. 2011
    ..There is strong evidence linking vascular disease to WMH, but limited evidence on its association with subcortical volumes...