M Thom

Summary

Affiliation: University College London
Country: UK

Publications

  1. ncbi Cortical dysplasia with angiodysgenesis and chronic inflammation in multifocal partial epilepsy
    M Thom
    Department of Neuropathology, The National Hospital for Neurology and Neurosurgery, London, UK
    Neurology 52:654-7. 1999
  2. ncbi Progesterone receptors are expressed with higher frequency by optic nerve sheath meningiomas
    M Thom
    Department of Neuropathology, National Hospital for Neurology and Neurosurgery, Queen Square, London, United Kingdom
    Clin Neuropathol 21:5-8. 2002
  3. ncbi Microdysgenesis with abnormal cortical myelinated fibres in temporal lobe epilepsy: a histopathological study with calbindin D-28-K immunohistochemistry
    M Thom
    Department of Neuropathology, Institute of Neurology, London, UK
    Neuropathol Appl Neurobiol 26:251-7. 2000
  4. ncbi Amygdala sclerosis in sudden and unexpected death in epilepsy
    M Thom
    Department of Neuropathology, National Hospital for Neurology and Neurosurgery, London, UK
    Epilepsy Res 37:53-62. 1999
  5. doi One hundred and one dysembryoplastic neuroepithelial tumors: an adult epilepsy series with immunohistochemical, molecular genetic, and clinical correlations and a review of the literature
    Maria Thom
    Department of Clinical and Experimental Epilepsy, University College London Institute of Neurology, London, UK
    J Neuropathol Exp Neurol 70:859-78. 2011
  6. pmc Quantitative grey matter histological measures do not correlate with grey matter probability values from in vivo MRI in the temporal lobe
    S H Eriksson
    Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, London WC1N3BG, UK
    J Neurosci Methods 181:111-8. 2009
  7. ncbi Drug resistance in epilepsy: human epilepsy
    S M Sisodiya
    University Department of Clinical Neurology, Institute of Neurology, University College London, UK
    Novartis Found Symp 243:167-74; discussion 174-9, 180-5. 2002
  8. pmc Correlation of quantitative MRI and neuropathology in epilepsy surgical resection specimens--T2 correlates with neuronal tissue in gray matter
    S H Eriksson
    Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, Queen Square, Box 29, London WC1N 3BG, UK
    Neuroimage 37:48-55. 2007
  9. ncbi Mcm2 labelling of balloon cells in focal cortical dysplasia
    M Thom
    Department of Clinical and Experimental Epilepsy, Institute of Neurology, London, UK
    Neuropathol Appl Neurobiol 31:580-8. 2005
  10. ncbi Cajal-Retzius cells, inhibitory interneuronal populations and neuropeptide Y expression in focal cortical dysplasia and microdysgenesis
    M Thom
    Department of Clinical and Experimental Epilepsy, Division of Neuropathology, Institute of Neurology, Queen Square, WC1N 3BG, London, UK
    Acta Neuropathol 105:561-9. 2003

Detail Information

Publications37

  1. ncbi Cortical dysplasia with angiodysgenesis and chronic inflammation in multifocal partial epilepsy
    M Thom
    Department of Neuropathology, The National Hospital for Neurology and Neurosurgery, London, UK
    Neurology 52:654-7. 1999
    ..The resected temporal lobe revealed cortical dysplasia and angiodysplasia with foci of more recent ischemic necrosis and chronic inflammation as an explanation for the clinical deterioration...
  2. ncbi Progesterone receptors are expressed with higher frequency by optic nerve sheath meningiomas
    M Thom
    Department of Neuropathology, National Hospital for Neurology and Neurosurgery, Queen Square, London, United Kingdom
    Clin Neuropathol 21:5-8. 2002
    ....
  3. ncbi Microdysgenesis with abnormal cortical myelinated fibres in temporal lobe epilepsy: a histopathological study with calbindin D-28-K immunohistochemistry
    M Thom
    Department of Neuropathology, Institute of Neurology, London, UK
    Neuropathol Appl Neurobiol 26:251-7. 2000
    ..In addition, prominent numbers of neurogliaform calbindin-positive nerve cells were observed in the microdysgenesis cases and the nature of these cells is speculated upon...
  4. ncbi Amygdala sclerosis in sudden and unexpected death in epilepsy
    M Thom
    Department of Neuropathology, National Hospital for Neurology and Neurosurgery, London, UK
    Epilepsy Res 37:53-62. 1999
    ....
  5. doi One hundred and one dysembryoplastic neuroepithelial tumors: an adult epilepsy series with immunohistochemical, molecular genetic, and clinical correlations and a review of the literature
    Maria Thom
    Department of Clinical and Experimental Epilepsy, University College London Institute of Neurology, London, UK
    J Neuropathol Exp Neurol 70:859-78. 2011
    ..This study supports the existence of a range of subtypes of DNT some with overlapping features with ganglioglioma; molecular genetic abnormalities were not predictive of atypical behavior...
  6. pmc Quantitative grey matter histological measures do not correlate with grey matter probability values from in vivo MRI in the temporal lobe
    S H Eriksson
    Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, London WC1N3BG, UK
    J Neurosci Methods 181:111-8. 2009
    ....
  7. ncbi Drug resistance in epilepsy: human epilepsy
    S M Sisodiya
    University Department of Clinical Neurology, Institute of Neurology, University College London, UK
    Novartis Found Symp 243:167-74; discussion 174-9, 180-5. 2002
    ..The timing shows that expression may be constitutive in some pathologies. These findings suggest that drug resistance proteins may contribute to drug resistance in refractory epilepsy...
  8. pmc Correlation of quantitative MRI and neuropathology in epilepsy surgical resection specimens--T2 correlates with neuronal tissue in gray matter
    S H Eriksson
    Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, Queen Square, Box 29, London WC1N 3BG, UK
    Neuroimage 37:48-55. 2007
    ..This will enable better identification and delineation of the structural causes of refractory focal epilepsy, and will be of particular benefit in patients in whom current optimal MRI does not identify a relevant abnormality...
  9. ncbi Mcm2 labelling of balloon cells in focal cortical dysplasia
    M Thom
    Department of Clinical and Experimental Epilepsy, Institute of Neurology, London, UK
    Neuropathol Appl Neurobiol 31:580-8. 2005
    ..Furthermore, as Mcm2 specifically identifies BC populations, this marker may be of diagnostic value in the subtyping of FCD lesions in patients with epilepsy...
  10. ncbi Cajal-Retzius cells, inhibitory interneuronal populations and neuropeptide Y expression in focal cortical dysplasia and microdysgenesis
    M Thom
    Department of Clinical and Experimental Epilepsy, Division of Neuropathology, Institute of Neurology, Queen Square, WC1N 3BG, London, UK
    Acta Neuropathol 105:561-9. 2003
    ....
  11. pmc Bilateral reorganization of the dentate gyrus in hippocampal sclerosis: a postmortem study
    M Thom
    Department of Clinical and Experimental Epilepsy, Division of Neuropathology, Institute of Neurology, Queen Square, London, UK
    Neurology 73:1033-40. 2009
    ..We aimed to investigate patterns of hippocampal abnormalities in a postmortem series as identified by NPY and dynorphin immunohistochemistry...
  12. ncbi Neocortical abnormalities of [11C]-flumazenil PET in mesial temporal lobe epilepsy
    A Hammers
    National Society for Epilepsy and Institute of Neurology, Queen Square, London
    Neurology 56:897-906. 2001
    ..The finding of abnormalities in patients who were thought to have unilateral HS only based on MRI suggests that more widespread abnormalities are present in HS...
  13. ncbi Vascular colocalization of P-glycoprotein, multidrug-resistance associated protein 1, breast cancer resistance protein and major vault protein in human epileptogenic pathologies
    S M Sisodiya
    Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, London WC1N 3BG, UK
    Neuropathol Appl Neurobiol 32:51-63. 2006
    ....
  14. ncbi Microdysgenesis in temporal lobe epilepsy. A quantitative and immunohistochemical study of white matter neurones
    M Thom
    Department of Neuropathology, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
    Brain 124:2299-309. 2001
    ..These findings suggest that microdysgenesis may be a significant lesion in temporal lobe epilepsy in terms of post-surgical prognosis...
  15. doi Expression patterns of glial fibrillary acidic protein (GFAP)-delta in epilepsy-associated lesional pathologies
    L Martinian
    Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College, London, UK
    Neuropathol Appl Neurobiol 35:394-405. 2009
    ..The aim of this study was to investigate its expression in common causes of lesion-related refractory epilepsy...
  16. doi Balloon cells associated with granule cell dispersion in the dentate gyrus in hippocampal sclerosis
    M Thom
    Department of Clinical and Experimental Epilepsy, Institute of Neurology and National Hospital for Neurology and Neurosurgery, Queen Square, London, WC1N 3BG, UK
    Acta Neuropathol 115:697-700. 2008
    ..This observation opens up the debate regarding the origin of balloon cells and CD34 expression and their temporal relationship to seizures...
  17. pmc Infundibulohypophysitis in a man presenting with diabetes insipidus and cavernous sinus involvement
    N Tubridy
    National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK
    J Neurol Neurosurg Psychiatry 71:798-801. 2001
    ..The diagnosis of infundibulohypophysitis was made on histological evidence. The patient was treated with prednisolone and methotrexate. At 9 months he is well, without symptoms, and the radiological abnormalities have resolved...
  18. ncbi Cortical neuronal densities and lamination in focal cortical dysplasia
    M Thom
    Division of Neuropathology and Department of Clinical and Experimental Epilepsy, Institute of Neurology, Queen Square, London, WC1N 3BG, UK
    Acta Neuropathol 110:383-92. 2005
    ..The preservation of relative differences in neuronal densities between cortical layers and laminar patterns of neurofilament staining in FCD would support the view that the temporal sequence of lamination is not affected...
  19. doi Calbindin D28K expression in relation to granule cell dispersion, mossy fibre sprouting and memory impairment in hippocampal sclerosis: a surgical and post mortem series
    L Martinian
    Department of Clinical and Experimental Epilepsy, Division of Neuropathology, UCL, Institute of Neurology and National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK
    Epilepsy Res 98:14-24. 2012
    ..The functional significance of CB loss, in terms of epileptogenesis and effects on memory, remain uncertain...
  20. ncbi Bilateral hippocampal granule cell dispersion: autopsy study of 3 infants
    B Harding
    Great Ormond Street Hospital for Children and National Hospital for Neurology and Neurosurgery, London, UK
    Neuropathol Appl Neurobiol 27:245-51. 2001
    ..The present observations bring into question the hypothesis that GCD is causally related to seizure activity in early life, suggesting an opposing view that it is an independent developmental disorder...
  21. ncbi Methodological aspects of 3D and automated 2D analyses of white matter neuronal density in temporal lobe epilepsy
    S H Eriksson
    Department of Clinical and Experimental Epilepsy, National Society for Epilepsy, London, UK
    Neuropathol Appl Neurobiol 32:260-70. 2006
    ..These findings have implications for studies requiring neuronal counts in normal and disease states...
  22. ncbi Sudden and unexpected death in epilepsy (SUDEP): evidence of acute neuronal injury using HSP-70 and c-Jun immunohistochemistry
    M Thom
    Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, London
    Neuropathol Appl Neurobiol 29:132-43. 2003
    ..The detection of HSP-70 positive neurones in the hippocampus in SUDEP is supportive of ante-mortem neuronal injury including a recent seizure prior to death...
  23. ncbi Bilateral isolated hippocampal malformation in temporal lobe epilepsy
    M Thom
    Department of Clinical and Esperimental Epilepsy, Institute of Neurology, National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, United Kingdom
    Neurology 58:1683-6. 2002
    ..Postmortem examination revealed abnormal position and complex convolutional malformations isolated to the hippocampal formation in an adult with temporal lobe epilepsy in whom MRI demonstrated bilateral hippocampal abnormalities...
  24. ncbi Brain biopsy in dementia
    J D Warren
    Dementia Research Centre, Institute of Neurology, London, UK
    Brain 128:2016-25. 2005
    ....
  25. pmc Relapsing intracranial Rosai-Dorfman disease
    A Petzold
    Department of Neuroimmunology, Institute of Neurology, Queen Square, London WC1N 3BG and Moorfields Eye Hospital, City Road, London EC1 2PD, UK
    J Neurol Neurosurg Psychiatry 71:538-41. 2001
    ..Review of the literature on intracranial Rosai-Dorfman disease leads to the suggestion that postoperative radiotherapy may be advisable in all cases...
  26. ncbi Mixed glioneuronal tumour of the fourth ventricle with prominent rosette formation
    T S Jacques
    Division of Neuropathology, The National Hospital for Neurology and Neurosurgery, Queen Square, London, UK
    Neuropathol Appl Neurobiol 32:217-20. 2006
    ..However, the clinical data available including the cases presented here, along with the histological features, suggest that these are low grade tumours with a good prognosis after surgical resection...
  27. ncbi The neuropathology of paraneoplastic syndromes
    F Scaravilli
    Department of Neuropathology, Institute of Neurology, The National Hospital Queen Square, London, UK
    Brain Pathol 9:251-60. 1999
    ..The Lambert-Eaton myasthenic syndrome will be dealt with separately in another paper in this symposium...
  28. pmc ALK positive inflammatory myofibroblastic tumour of the pineal region
    A J Clarke
    Department of Neurology, National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK
    J Clin Pathol 58:981-3. 2005
    ..There was no tumour recurrence during 18 months of follow-up. Our case extends both the age range and sites of occurrence of this rare tumour...
  29. ncbi Drug resistance in epilepsy: expression of drug resistance proteins in common causes of refractory epilepsy
    S M Sisodiya
    Epilepsy Research Group, University Department of Clinical Neurology, University College London, London, UK
    Brain 125:22-31. 2002
    ..We propose that overexpressed resistance proteins lower the interstitial concentration of AEDs in the vicinity of the epileptogenic pathology and thereby render the epilepsy caused by these pathologies resistant to treatment with AEDs...
  30. doi A comparative study of the dentate gyrus in hippocampal sclerosis in epilepsy and dementia
    R Bandopadhyay
    Department of Clinical and Experimental Epilepsy, UCL, Institute of Neurology and National Hospital for Neurology and Neurosurgery, London, UK
    Neuropathol Appl Neurobiol 40:177-90. 2014
    ..We sought to compare the pathology of HSE and HSD , focusing on re-organization in the dentate gyrus...
  31. ncbi Aggressive CNS lupus vasculitis in the absence of systemic disease activity
    C M Everett
    Department of Molecular Neuroscience and Centre for Neuromuscular Disease, Institute of Neurology and The National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK
    Rheumatology (Oxford) 47:107-9. 2008
  32. ncbi Abnormalities of grey and white matter [11C]flumazenil binding in temporal lobe epilepsy with normal MRI
    A Hammers
    MRC Clinical Sciences Centre and Division of Neuroscience, Faculty of Medicine, Imperial College, London, UK
    Brain 125:2257-71. 2002
    ..Furthermore, increases in FMZ binding in TLWM, indicating microdysgenesis, were detected in the majority of these patients and may represent the structural basis of their epilepsy...
  33. ncbi Unihemispheric cerebral vasculitis mimicking Rasmussen's encephalitis
    C Derry
    Department of Neuroinflammation, Institute of Neurology, Queen Square, London, UK
    Neurology 58:327-8. 2002
  34. ncbi Diffuse cerebral gangliocytoma in an adult with late-onset refractory epilepsy
    B Ratilal
    Neuropathol Appl Neurobiol 33:706-9. 2007
  35. ncbi Persistent reelin-expressing Cajal-Retzius cells in polymicrogyria
    S H Eriksson
    The National Society for Epilepsy and Epilepsy Research Group, University Department of Clinical Neurology, University College London, UK
    Brain 124:1350-61. 2001
    ....
  36. pmc Studies of GABA(B) receptors labelled with [(3)H]-CGP62349 in hippocampus resected from patients with temporal lobe epilepsy
    A P Princivalle
    Division of Neuroscience, Department of Pharmacology, Medical School, University of Birmingham, UK
    Br J Pharmacol 136:1099-106. 2002
    ..These results suggest altered GABA(B) receptor function may occur in human TLE, possibly as a result of synaptic reorganization, and may contribute to epileptogenesis...
  37. ncbi GABA(B1a), GABA(B1b) AND GABA(B2) mRNA variants expression in hippocampus resected from patients with temporal lobe epilepsy
    A P Princivalle
    Department of Pharmacology, Medical School, University of Birmingham, Birmingham B15 2TT, UK
    Neuroscience 122:975-84. 2003
    ..These results demonstrate that altered GABA(B) receptor mRNA expression occurs in human TLE; possibly the observed changes may also serve to counteract ongoing hyperexcitability...