Research Topics
Species | M ThomSummaryAffiliation: University College London Country: UK Publications
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Publications
Cortical dysplasia with angiodysgenesis and chronic inflammation in multifocal partial epilepsyM Thom
Department of Neuropathology, The National Hospital for Neurology and Neurosurgery, London, UK
Neurology 52:654-7. 1999..The resected temporal lobe revealed cortical dysplasia and angiodysplasia with foci of more recent ischemic necrosis and chronic inflammation as an explanation for the clinical deterioration...
ALK positive inflammatory myofibroblastic tumour of the pineal regionA J Clarke
Department of Neurology, National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK
J Clin Pathol 58:981-3. 2005..There was no tumour recurrence during 18 months of follow-up. Our case extends both the age range and sites of occurrence of this rare tumour...- Cortical neuronal densities and lamination in focal cortical dysplasiaM Thom
Division of Neuropathology and Department of Clinical and Experimental Epilepsy, Institute of Neurology, Queen Square, London, WC1N 3BG, UK
Acta Neuropathol 110:383-92. 2005..The preservation of relative differences in neuronal densities between cortical layers and laminar patterns of neurofilament staining in FCD would support the view that the temporal sequence of lamination is not affected... - Depletion of reduced glutathione precedes inactivation of mitochondrial enzymes following limbic status epilepticus in the rat hippocampusHannah Sleven
Epilepsy Group, Centre for Clinical Neurosciences, St. George's, University of London, Cranmer Terrace, London SW17 0RE, UK
Neurochem Int 48:75-82. 2006.... - Mixed glioneuronal tumour of the fourth ventricle with prominent rosette formationT S Jacques
Division of Neuropathology, The National Hospital for Neurology and Neurosurgery, Queen Square, London, UK
Neuropathol Appl Neurobiol 32:217-20. 2006..However, the clinical data available including the cases presented here, along with the histological features, suggest that these are low grade tumours with a good prognosis after surgical resection... - Variability of sclerosis along the longitudinal hippocampal axis in epilepsy: A post mortem studyMaria Thom
Department of Clinical and Experimental Epilepsy, UK Division of Neuropathology, Institute of Neurology and National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK Electronic address
Epilepsy Res 102:45-59. 2012..In conclusion, this series highlights the variability of HS along the longitudinal axis. Further studies are required to identify factors that lead to focal versus diffuse HS... - The application of cortical layer markers in the evaluation of cortical dysplasias in epilepsyGeorge Hadjivassiliou
Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
Acta Neuropathol 120:517-28. 2010..Finally, immature cell types (Otx1, Pax6 and Tbr2) were noted in varied pathologies. One possibility is activation of progenitor cell populations which could contribute to the pathophysiology of these lesions... - Neurofibrillary tangle pathology and Braak staging in chronic epilepsy in relation to traumatic brain injury and hippocampal sclerosis: a post-mortem studyMaria Thom
Department of Clinical and Experimental Epilepsy, UCL, Institute of Neurology and National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK
Brain 134:2969-81. 2011..Traumatic brain injury, but not seizures, was associated with tau protein accumulation in this series. It is likely that Alzheimer's disease pathology is not the sole explanation for cognitive decline associated with epilepsy... - Cajal-Retzius cells, inhibitory interneuronal populations and neuropeptide Y expression in focal cortical dysplasia and microdysgenesisM Thom
Department of Clinical and Experimental Epilepsy, Division of Neuropathology, Institute of Neurology, Queen Square, WC1N 3BG, London, UK
Acta Neuropathol 105:561-9. 2003.... - Distribution of cortical interneurons in grey matter heterotopia in patients with epilepsyMaria Thom
Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, London, United Kingdom
Epilepsia 45:916-23. 2004..We aimed to identify the subtypes and localisation of interneurons within grey matter heterotopia relative to cortex... - Quantitative post-mortem study of the hippocampus in chronic epilepsy: seizures do not inevitably cause neuronal lossMaria Thom
Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College, London, UK
Brain 128:1344-57. 2005..In conclusion, seizures do not invariably lead to hippocampal injury and white matter heterotopia is not invariably associated with hippocampal sclerosis... - Cell proliferation and granule cell dispersion in human hippocampal sclerosisMaria Thom
Department of Clinical and Experimental Epilepsy, Institute of Neurology, London, UK
J Neuropathol Exp Neurol 64:194-201. 2005..These findings support the view that GCD may be a phenomenon related to increased progenitor cell proliferation in patients with hippocampal damage and chronic epilepsy... - Recent advances in the neuropathology of focal lesions in epilepsyMaria Thom
National Hospital for Neurology and Neurosurgery, Queen Square, London, WC1N 3BG, UK
Expert Rev Neurother 4:973-84. 2004..The important contribution of astrocytes to epileptogenesis is also unfolding and is briefly discussed, as are the possible cellular mechanisms of drug resistance... - Bilateral reorganization of the dentate gyrus in hippocampal sclerosis: a postmortem studyM Thom
Department of Clinical and Experimental Epilepsy, Division of Neuropathology, Institute of Neurology, Queen Square, London, UK
Neurology 73:1033-40. 2009..We aimed to investigate patterns of hippocampal abnormalities in a postmortem series as identified by NPY and dynorphin immunohistochemistry... - Mcm2 labelling of balloon cells in focal cortical dysplasiaM Thom
Department of Clinical and Experimental Epilepsy, Institute of Neurology, London, UK
Neuropathol Appl Neurobiol 31:580-8. 2005..Furthermore, as Mcm2 specifically identifies BC populations, this marker may be of diagnostic value in the subtyping of FCD lesions in patients with epilepsy... - An investigation of the expression of G1-phase cell cycle proteins in focal cortical dysplasia type IIBMaria Thom
Department of Clinical and Experimental Epilepsy, Division of Neuropathology, Institute of Neurology, National Hospital for Neurology and Neurosurgery, Queen Square, London, UK
J Neuropathol Exp Neurol 66:1045-55. 2007..These findings also suggest that dysregulation of cell cycle pathways may occur in focal cortical dysplasia, which opens further areas for exploration as potential new treatment avenues... 
Balloon cells associated with granule cell dispersion in the dentate gyrus in hippocampal sclerosisM Thom
Department of Clinical and Experimental Epilepsy, Institute of Neurology and National Hospital for Neurology and Neurosurgery, Queen Square, London, WC1N 3BG, UK
Acta Neuropathol 115:697-700. 2008..This observation opens up the debate regarding the origin of balloon cells and CD34 expression and their temporal relationship to seizures...- Hippocampal sclerosis: progress since SommerMaria Thom
University College London, Institute of Neurology, Division of Neuropathology, London, UK
Brain Pathol 19:565-72. 2009.... - Temporal lobe sclerosis associated with hippocampal sclerosis in temporal lobe epilepsy: neuropathological featuresMaria Thom
Division of Neuropathology, Department of Clinical and Experimental Epilepsy, UCL, Institute of Neurology, National Hospital for Neurology and Neurosurgery, Queen Square, London, United Kingdom
J Neuropathol Exp Neurol 68:928-38. 2009..Temporal lobe sclerosis is likely an acquired process with accompanying reorganizational dysplasia and an extension of mesial temporal sclerosis rather than a separate pathological entity... - Reliability of patterns of hippocampal sclerosis as predictors of postsurgical outcomeMaria Thom
Divisions of Neuropathology and Neurology, Department of Clinical and Experimental Epilepsy, University College London, Institute of Neurology and National Hospital for Neurology and Neurosurgery, Queen Square, London, U K
Epilepsia 51:1801-8. 2010..Atypical patterns of HS may be associated with poorer outcomes. Our aim was to identify atypical HS cases from a large surgical series and to correlate pathology with clinical and outcome data... - Sudden and unexpected death in epilepsy (SUDEP): evidence of acute neuronal injury using HSP-70 and c-Jun immunohistochemistryM Thom
Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, London
Neuropathol Appl Neurobiol 29:132-43. 2003..The detection of HSP-70 positive neurones in the hippocampus in SUDEP is supportive of ante-mortem neuronal injury including a recent seizure prior to death... - Microdysgenesis in temporal lobe epilepsy. A quantitative and immunohistochemical study of white matter neuronesM Thom
Department of Neuropathology, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
Brain 124:2299-309. 2001..These findings suggest that microdysgenesis may be a significant lesion in temporal lobe epilepsy in terms of post-surgical prognosis... - Bilateral isolated hippocampal malformation in temporal lobe epilepsyM Thom
Department of Clinical and Esperimental Epilepsy, Institute of Neurology, National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, United Kingdom
Neurology 58:1683-6. 2002..Postmortem examination revealed abnormal position and complex convolutional malformations isolated to the hippocampal formation in an adult with temporal lobe epilepsy in whom MRI demonstrated bilateral hippocampal abnormalities... - Drug resistance in epilepsy: human epilepsyS M Sisodiya
University Department of Clinical Neurology, Institute of Neurology, University College London, UK
Novartis Found Symp 243:167-74; discussion 174-9, 180-5. 2002..The timing shows that expression may be constitutive in some pathologies. These findings suggest that drug resistance proteins may contribute to drug resistance in refractory epilepsy... - Quantitative grey matter histological measures do not correlate with grey matter probability values from in vivo MRI in the temporal lobeS H Eriksson
Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, London WC1N3BG, UK
J Neurosci Methods 181:111-8. 2009.... - Correlation of quantitative MRI and neuropathology in epilepsy surgical resection specimens--T2 correlates with neuronal tissue in gray matterS H Eriksson
Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, Queen Square, Box 29, London WC1N 3BG, UK
Neuroimage 37:48-55. 2007..This will enable better identification and delineation of the structural causes of refractory focal epilepsy, and will be of particular benefit in patients in whom current optimal MRI does not identify a relevant abnormality... - Persistent reelin-expressing Cajal-Retzius cells in polymicrogyriaS H Eriksson
The National Society for Epilepsy and Epilepsy Research Group, University Department of Clinical Neurology, University College London, UK
Brain 124:1350-61. 2001.... - Drug resistance in epilepsy: expression of drug resistance proteins in common causes of refractory epilepsyS M Sisodiya
Epilepsy Research Group, University Department of Clinical Neurology, University College London, London, UK
Brain 125:22-31. 2002..We propose that overexpressed resistance proteins lower the interstitial concentration of AEDs in the vicinity of the epileptogenic pathology and thereby render the epilepsy caused by these pathologies resistant to treatment with AEDs... - Expression patterns of glial fibrillary acidic protein (GFAP)-delta in epilepsy-associated lesional pathologiesL Martinian
Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College, London, UK
Neuropathol Appl Neurobiol 35:394-405. 2009..The aim of this study was to investigate its expression in common causes of lesion-related refractory epilepsy... - Neocortical abnormalities of [11C]-flumazenil PET in mesial temporal lobe epilepsyA Hammers
National Society for Epilepsy and Institute of Neurology, Queen Square, London
Neurology 56:897-906. 2001..The finding of abnormalities in patients who were thought to have unilateral HS only based on MRI suggests that more widespread abnormalities are present in HS... - Microdysgenesis with abnormal cortical myelinated fibres in temporal lobe epilepsy: a histopathological study with calbindin D-28-K immunohistochemistryM Thom
Department of Neuropathology, Institute of Neurology, London, UK
Neuropathol Appl Neurobiol 26:251-7. 2000..In addition, prominent numbers of neurogliaform calbindin-positive nerve cells were observed in the microdysgenesis cases and the nature of these cells is speculated upon... - Amygdala sclerosis in sudden and unexpected death in epilepsyM Thom
Department of Neuropathology, National Hospital for Neurology and Neurosurgery, London, UK
Epilepsy Res 37:53-62. 1999.... - Vascular colocalization of P-glycoprotein, multidrug-resistance associated protein 1, breast cancer resistance protein and major vault protein in human epileptogenic pathologiesS M Sisodiya
Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, London WC1N 3BG, UK
Neuropathol Appl Neurobiol 32:51-63. 2006.... - Cytoarchitectural abnormalities in hippocampal sclerosisMaria Thom
Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College of London, United Kingdom
J Neuropathol Exp Neurol 61:510-9. 2002..Although a role for Cajal-Retzius cells is therefore not implicated in the mechanism of granule cell disorganization, their excess number may be indicative of underlying hippocampal maldevelopment in HS... - Relapsing intracranial Rosai-Dorfman diseaseA Petzold
Department of Neuroimmunology, Institute of Neurology, Queen Square, London WC1N 3BG and Moorfields Eye Hospital, City Road, London EC1 2PD, UK
J Neurol Neurosurg Psychiatry 71:538-41. 2001..Review of the literature on intracranial Rosai-Dorfman disease leads to the suggestion that postoperative radiotherapy may be advisable in all cases... - Methodological aspects of 3D and automated 2D analyses of white matter neuronal density in temporal lobe epilepsyS H Eriksson
Department of Clinical and Experimental Epilepsy, National Society for Epilepsy, London, UK
Neuropathol Appl Neurobiol 32:260-70. 2006..These findings have implications for studies requiring neuronal counts in normal and disease states... - Infundibulohypophysitis in a man presenting with diabetes insipidus and cavernous sinus involvementN Tubridy
National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK
J Neurol Neurosurg Psychiatry 71:798-801. 2001..The diagnosis of infundibulohypophysitis was made on histological evidence. The patient was treated with prednisolone and methotrexate. At 9 months he is well, without symptoms, and the radiological abnormalities have resolved... - PROPELLER MRI visualizes detailed pathology of hippocampal sclerosisSofia H Eriksson
Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, London, UK
Epilepsia 49:33-9. 2008..The aim of the current report was to explore PROPELLER image quality of the hippocampus compared to routine sequences... - Sulcogyral variation in NMDA receptor 2A/B subunit immunoreactivity in human brainS M Sisodiya
Epilepsy Research Group, University Department of Clinical Neurology, University College London, UK
Neuroreport 11:2601-6. 2000..Neurofilament and calretinin immunoreactivity do not show this phenomenon. The findings suggest novel functional regionalization at the sulcogyral level in normal human brain... - Calbindin D28K expression in relation to granule cell dispersion, mossy fibre sprouting and memory impairment in hippocampal sclerosis: a surgical and post mortem seriesL Martinian
Department of Clinical and Experimental Epilepsy, Division of Neuropathology, UCL, Institute of Neurology and National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK
Epilepsy Res 98:14-24. 2012..The functional significance of CB loss, in terms of epileptogenesis and effects on memory, remain uncertain... - Bilateral hippocampal granule cell dispersion: autopsy study of 3 infantsB Harding
Great Ormond Street Hospital for Children and National Hospital for Neurology and Neurosurgery, London, UK
Neuropathol Appl Neurobiol 27:245-51. 2001..The present observations bring into question the hypothesis that GCD is causally related to seizure activity in early life, suggesting an opposing view that it is an independent developmental disorder... - Lack of support for a role for RLIP76 (RALBP1) in response to treatment or predisposition to epilepsyNicole Soranzo
Department of Clinical and Experimental Epilepsy, Institute of Neurology, UCL, London, UK
Epilepsia 48:674-83. 2007..Knowledge of which transporters may be critical in drug resistance is important for design of potential therapies. We tested the hypothesis that RLIP76 mediates AED resistance using methods complementary to those in the original report... - Deregulation of cdk5 in Hippocampal sclerosisArjune Sen
Department of Clinical and Experimental Epilepsy, The Institute of Neurology, University College London, Queen Square, London, U.K
J Neuropathol Exp Neurol 65:55-66. 2006..Our results suggest that p25 is pathologically increased in HS and that deregulation of cdk5 by p25 might contribute to neuronal death in this condition... - The neuropathology of paraneoplastic syndromesF Scaravilli
Department of Neuropathology, Institute of Neurology, The National Hospital Queen Square, London, UK
Brain Pathol 9:251-60. 1999..The Lambert-Eaton myasthenic syndrome will be dealt with separately in another paper in this symposium... - Focal cortical dysplasia type II: biological features and clinical perspectivesSanjay M Sisodiya
Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, Queen Square, London, UK
Lancet Neurol 8:830-43. 2009.... - Immunolabeling recovery in archival, post-mortem, human brain tissue using modified antigen retrieval and the catalyzed signal amplification systemJoan Y W Liu
Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology and National Hospital for Neurology and Neurosurgery, 33 Queen Square, London WC1N 3BG, UK
J Neurosci Methods 190:49-56. 2010..Importantly, this study provides a method of overcoming formalin-masking of antigens in long-fixed human tissue, thus allowing essential immunohistochemical studies to be undertaken using precious human tissue... - In vivo monitoring of neuronal loss in traumatic brain injury: a microdialysis studyAxel Petzold
Department of Neuroimmunology, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK
Brain 134:464-83. 2011.... - Abnormal expression of cdk5 in focal cortical dysplasia in humansSanjay M Sisodiya
Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
Neurosci Lett 328:217-20. 2002..Here we examine eight cases of human FCD for expression of cdk5. We show abnormal cdk5 immunoreactivity and aggregation of protein suggesting alterations in cdk5 may also be involved in this important epileptogenic human pathology... - Widespread upregulation of drug-resistance proteins in fatal human status epilepticusSanjay M Sisodiya
Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, London, England
Epilepsia 44:261-4. 2003..We wished to determine if status epilepticus might cause upregulation of these proteins... - The potential role of cyclin-dependent kinase 5 in focal cortical dysplasiaArjune Sen
Department of Clinical and Experimental Epilepsy, University College London, London, UK
Dev Neurosci 30:96-104. 2008.... - Cortical neuronal loss and hippocampal sclerosis are not detected by voxel-based morphometry in individual epilepsy surgery patientsSofia H Eriksson
Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, London WC1N3BG, United Kingdom
Hum Brain Mapp 30:3351-60. 2009..This suggests that the methodology may currently not be suitable to detect particular occult abnormalities possibly associated with seizure onset zone in individual epilepsy patients with unremarkable standard structural MRI... - Mitochondrial dysfunction associated with neuronal death following status epilepticus in ratHannah R Cock
Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, Queen Square, WC1N 3BG, London, UK
Epilepsy Res 48:157-68. 2002..The pattern of abnormalities is consistent with reversible mechanisms being involved in excitotoxic cell damage. This, together with the timing of changes, suggests new avenues for therapeutic intervention... - Reliable registration of preoperative MRI with histopathology after temporal lobe resectionsSofia H Eriksson
Department of Clinical and Experimental Epilepsy, National Society for Epilepsy, United Kingdom
Epilepsia 46:1646-53. 2005..We have developed a method to facilitate registration of preoperative MRI with the resected specimen and to enable correlation of MRI findings with histopathology... - Synergism between topiramate and budipine in refractory status epilepticus in the ratAndrew Fisher
Department of Clinical and Experimental Epilepsy, Institute of Neurology, UCL, London, United Kingdom
Epilepsia 45:1300-7. 2004..CONCLUSIONS: Budipine and TPM are an effective drug combination in stopping self-sustained status epilepticus, and TPM alone was neuroprotective, despite the continuation of seizure activity... - Major vault protein, a marker of drug resistance, is upregulated in refractory epilepsySanjay M Sisodiya
Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, England
Epilepsia 44:1388-96. 2003..Other proteins associated with resistance in cancer include major vault protein (MVP) and breast cancer resistance protein (BCRP). We hypothesized that these proteins would also be upregulated in human epileptogenic pathologies... - Brain biopsy in dementiaJ D Warren
Dementia Research Centre, Institute of Neurology, London, UK
Brain 128:2016-25. 2005.... - Hippocampal malformations do not necessarily evolve into hippocampal sclerosisArjune Sen
Department of Clinical and Experimental Epilepsy, The Institute of Neurology, University College London, London, England
Epilepsia 46:939-43. 2005..CONCLUSIONS: These two cases demonstrate histologically that, even in long-standing epilepsy, malformations of the hippocampus do not necessarily develop into hippocampal sclerosis... - Balloon cells in human cortical dysplasia and tuberous sclerosis: isolation of a pathological progenitor-like cellShireena A Yasin
Department of Histopathology, Great Ormond Street Hospital, London, UK
Acta Neuropathol 120:85-96. 2010..We have characterised the immunohistochemical, morphological and ultrastructural features of these cells. This is the first isolation of an abnormal cell with features of a progenitor/stem cell from a non-neoplastic disease of the brain... - Increased immunoreactivity of cdk5 activators in hippocampal sclerosisArjune Sen
Department of Clinical and Experimental Epilepsy, Division of Neuropathology, Institute of Neurology, University College London, UK
Neuroreport 18:511-6. 2007..Our findings suggest that deregulation of cyclin-dependent kinase 5 might contribute to the pathogenesis of hippocampal sclerosis... - Pathological tau tangles localize to focal cortical dysplasia in older patientsArjune Sen
Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, Queen Square, London, UK
Epilepsia 48:1447-54. 2007..We therefore hypothesized that the developmentally abnormal cortex of FCD might be more susceptible to tau-mediated neurodegeneration than adjacent histologically normal cortex... - Increased NKCC1 expression in refractory human epilepsyArjune Sen
Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, United Kingdom
Epilepsy Res 74:220-7. 2007..Our results suggest that NKCC1 might contribute to the pathogenesis or pathophysiology of HS and FCD, thereby potentially offering a new therapeutic target in the treatment of pharmacoresistant epilepsy... - Abnormalities of grey and white matter [11C]flumazenil binding in temporal lobe epilepsy with normal MRIA Hammers
MRC Clinical Sciences Centre and Division of Neuroscience, Faculty of Medicine, Imperial College, London, UK
Brain 125:2257-71. 2002..Furthermore, increases in FMZ binding in TLWM, indicating microdysgenesis, were detected in the majority of these patients and may represent the structural basis of their epilepsy... - Tonic GABA(A) receptor-mediated currents in human brainAnnalisa Scimemi
Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
Eur J Neurosci 24:1157-60. 2006..These tonic currents have cell type-specific pharmacologies, opening up the possibility of targeted therapeutics... - Doublecortin expression in focal cortical dysplasia in epilepsyNisaharan Srikandarajah
Department of Clinical and Experimental Epilepsy, Institute of Neurology, Queen Square, London, United Kingdom
Epilepsia 50:2619-28. 2009..The aim was to study DCX expression patterns in such lesions compared to normal developing and mature cortex... - Genetic predictors of the maximum doses patients receive during clinical use of the anti-epileptic drugs carbamazepine and phenytoinSarah K Tate
Department of Biology, University College London, Darwin Building, Gower Street, London WC1E 6BT, United Kingdom
Proc Natl Acad Sci U S A 102:5507-12. 2005..Although the case made here is compelling, our results cannot be considered definitive or ready for clinical application until they are confirmed by independent replication... - Aggressive CNS lupus vasculitis in the absence of systemic disease activityC M Everett
Department of Molecular Neuroscience and Centre for Neuromuscular Disease, Institute of Neurology and The National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK
Rheumatology (Oxford) 47:107-9. 2008 - Progesterone receptors are expressed with higher frequency by optic nerve sheath meningiomasM Thom
Department of Neuropathology, National Hospital for Neurology and Neurosurgery, Queen Square, London, United Kingdom
Clin Neuropathol 21:5-8. 2002.... - Unihemispheric cerebral vasculitis mimicking Rasmussen's encephalitisC Derry
Department of Neuroinflammation, Institute of Neurology, Queen Square, London, UK
Neurology 58:327-8. 2002 - Mesial temporal lobe epilepsy: How do we improve surgical outcome?Maria Thom
Institute of Neurology, National Hospital for Neurology and Neurosurgery, University College London, London, UK
Ann Neurol 68:424-34. 2010..That recognition may lead to identifying the appropriate subgroups that will require different diagnostic and surgical approaches to improve surgical outcomes... - Diffusion tensor imaging in refractory epilepsyFergus J Rugg-Gunn
MRI Unit, National Society for Epilepsy and Research Department of Clinical and Experimental Epilepsy, Institute of Neurology, London, UK
Lancet 359:1748-51. 2002..Histopathological examination of the resected tissue showed gliosis. Our findings may affect the investigation of similar patients, and provide histopathological confirmation of diffusion abnormalities... - Microdysgenesis in mesial temporal lobe epilepsySofia H Eriksson
Ann Neurol 55:596-7; author reply 597. 2004 - Quantitative neuropathology of the entorhinal cortex region in patients with hippocampal sclerosis and temporal lobe epilepsyStephen Dawodu
Division of Neuropathology and Department of Clinical and Experimental Epilepsy, National Hospital for Neurology and Neurosurgery and Institute of Neurology, London, England
Epilepsia 46:23-30. 2005..CONCLUSIONS: A stereotypical pattern of neuronal loss and gliosis in the EC region in patients with HS is not confirmed that distinguishes this pathologic process from that in patients with lesional TLE... - Ammon's horn sclerosis: a maldevelopmental disorder associated with temporal lobe epilepsyIngmar Blumcke
Department of Neuropathology, University of Bonn Medical Center, Germany
Brain Pathol 12:199-211. 2002..Its association with a lowered seizure threshold and an increased susceptibility for segmental cell loss in the hippocampus during the long course of the disease may constitute additional elements in a pathogenic cascade...