M Thom

Summary

Affiliation: University College London
Country: UK

Publications

  1. ncbi request reprint Cortical dysplasia with angiodysgenesis and chronic inflammation in multifocal partial epilepsy
    M Thom
    Department of Neuropathology, The National Hospital for Neurology and Neurosurgery, London, UK
    Neurology 52:654-7. 1999
  2. pmc ALK positive inflammatory myofibroblastic tumour of the pineal region
    A J Clarke
    Department of Neurology, National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK
    J Clin Pathol 58:981-3. 2005
  3. ncbi request reprint Cortical neuronal densities and lamination in focal cortical dysplasia
    M Thom
    Division of Neuropathology and Department of Clinical and Experimental Epilepsy, Institute of Neurology, Queen Square, London, WC1N 3BG, UK
    Acta Neuropathol 110:383-92. 2005
  4. ncbi request reprint Depletion of reduced glutathione precedes inactivation of mitochondrial enzymes following limbic status epilepticus in the rat hippocampus
    Hannah Sleven
    Epilepsy Group, Centre for Clinical Neurosciences, St George s, University of London, Cranmer Terrace, London SW17 0RE, UK
    Neurochem Int 48:75-82. 2006
  5. ncbi request reprint Mixed glioneuronal tumour of the fourth ventricle with prominent rosette formation
    T S Jacques
    Division of Neuropathology, The National Hospital for Neurology and Neurosurgery, Queen Square, London, UK
    Neuropathol Appl Neurobiol 32:217-20. 2006
  6. pmc Variability of sclerosis along the longitudinal hippocampal axis in epilepsy: a post mortem study
    Maria Thom
    Department of Clinical and Experimental Epilepsy, UK
    Epilepsy Res 102:45-59. 2012
  7. pmc The application of cortical layer markers in the evaluation of cortical dysplasias in epilepsy
    George Hadjivassiliou
    Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
    Acta Neuropathol 120:517-28. 2010
  8. pmc Temporal lobe sclerosis associated with hippocampal sclerosis in temporal lobe epilepsy: neuropathological features
    Maria Thom
    Division of Neuropathology, Department of Clinical and Experimental Epilepsy, UCL, Institute of Neurology, National Hospital for Neurology and Neurosurgery, Queen Square, London, United Kingdom
    J Neuropathol Exp Neurol 68:928-38. 2009
  9. pmc Neurofibrillary tangle pathology and Braak staging in chronic epilepsy in relation to traumatic brain injury and hippocampal sclerosis: a post-mortem study
    Maria Thom
    Department of Clinical and Experimental Epilepsy, UCL, Institute of Neurology and National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK
    Brain 134:2969-81. 2011
  10. ncbi request reprint Cell proliferation and granule cell dispersion in human hippocampal sclerosis
    Maria Thom
    Department of Clinical and Experimental Epilepsy, Institute of Neurology, London, UK
    J Neuropathol Exp Neurol 64:194-201. 2005

Collaborators

Detail Information

Publications74

  1. ncbi request reprint Cortical dysplasia with angiodysgenesis and chronic inflammation in multifocal partial epilepsy
    M Thom
    Department of Neuropathology, The National Hospital for Neurology and Neurosurgery, London, UK
    Neurology 52:654-7. 1999
    ..The resected temporal lobe revealed cortical dysplasia and angiodysplasia with foci of more recent ischemic necrosis and chronic inflammation as an explanation for the clinical deterioration...
  2. pmc ALK positive inflammatory myofibroblastic tumour of the pineal region
    A J Clarke
    Department of Neurology, National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK
    J Clin Pathol 58:981-3. 2005
    ..There was no tumour recurrence during 18 months of follow-up. Our case extends both the age range and sites of occurrence of this rare tumour...
  3. ncbi request reprint Cortical neuronal densities and lamination in focal cortical dysplasia
    M Thom
    Division of Neuropathology and Department of Clinical and Experimental Epilepsy, Institute of Neurology, Queen Square, London, WC1N 3BG, UK
    Acta Neuropathol 110:383-92. 2005
    ..The preservation of relative differences in neuronal densities between cortical layers and laminar patterns of neurofilament staining in FCD would support the view that the temporal sequence of lamination is not affected...
  4. ncbi request reprint Depletion of reduced glutathione precedes inactivation of mitochondrial enzymes following limbic status epilepticus in the rat hippocampus
    Hannah Sleven
    Epilepsy Group, Centre for Clinical Neurosciences, St George s, University of London, Cranmer Terrace, London SW17 0RE, UK
    Neurochem Int 48:75-82. 2006
    ....
  5. ncbi request reprint Mixed glioneuronal tumour of the fourth ventricle with prominent rosette formation
    T S Jacques
    Division of Neuropathology, The National Hospital for Neurology and Neurosurgery, Queen Square, London, UK
    Neuropathol Appl Neurobiol 32:217-20. 2006
    ..However, the clinical data available including the cases presented here, along with the histological features, suggest that these are low grade tumours with a good prognosis after surgical resection...
  6. pmc Variability of sclerosis along the longitudinal hippocampal axis in epilepsy: a post mortem study
    Maria Thom
    Department of Clinical and Experimental Epilepsy, UK
    Epilepsy Res 102:45-59. 2012
    ..In conclusion, this series highlights the variability of HS along the longitudinal axis. Further studies are required to identify factors that lead to focal versus diffuse HS...
  7. pmc The application of cortical layer markers in the evaluation of cortical dysplasias in epilepsy
    George Hadjivassiliou
    Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
    Acta Neuropathol 120:517-28. 2010
    ..Finally, immature cell types (Otx1, Pax6 and Tbr2) were noted in varied pathologies. One possibility is activation of progenitor cell populations which could contribute to the pathophysiology of these lesions...
  8. pmc Temporal lobe sclerosis associated with hippocampal sclerosis in temporal lobe epilepsy: neuropathological features
    Maria Thom
    Division of Neuropathology, Department of Clinical and Experimental Epilepsy, UCL, Institute of Neurology, National Hospital for Neurology and Neurosurgery, Queen Square, London, United Kingdom
    J Neuropathol Exp Neurol 68:928-38. 2009
    ..Temporal lobe sclerosis is likely an acquired process with accompanying reorganizational dysplasia and an extension of mesial temporal sclerosis rather than a separate pathological entity...
  9. pmc Neurofibrillary tangle pathology and Braak staging in chronic epilepsy in relation to traumatic brain injury and hippocampal sclerosis: a post-mortem study
    Maria Thom
    Department of Clinical and Experimental Epilepsy, UCL, Institute of Neurology and National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK
    Brain 134:2969-81. 2011
    ..Traumatic brain injury, but not seizures, was associated with tau protein accumulation in this series. It is likely that Alzheimer's disease pathology is not the sole explanation for cognitive decline associated with epilepsy...
  10. ncbi request reprint Cell proliferation and granule cell dispersion in human hippocampal sclerosis
    Maria Thom
    Department of Clinical and Experimental Epilepsy, Institute of Neurology, London, UK
    J Neuropathol Exp Neurol 64:194-201. 2005
    ..These findings support the view that GCD may be a phenomenon related to increased progenitor cell proliferation in patients with hippocampal damage and chronic epilepsy...
  11. ncbi request reprint Reliability of patterns of hippocampal sclerosis as predictors of postsurgical outcome
    Maria Thom
    Divisions of Neuropathology and Neurology, Department of Clinical and Experimental Epilepsy, University College London, Institute of Neurology and National Hospital for Neurology and Neurosurgery, Queen Square, London, U K
    Epilepsia 51:1801-8. 2010
    ..Atypical patterns of HS may be associated with poorer outcomes. Our aim was to identify atypical HS cases from a large surgical series and to correlate pathology with clinical and outcome data...
  12. ncbi request reprint Sudden and unexpected death in epilepsy (SUDEP): evidence of acute neuronal injury using HSP-70 and c-Jun immunohistochemistry
    M Thom
    Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, London
    Neuropathol Appl Neurobiol 29:132-43. 2003
    ..The detection of HSP-70 positive neurones in the hippocampus in SUDEP is supportive of ante-mortem neuronal injury including a recent seizure prior to death...
  13. ncbi request reprint Quantitative post-mortem study of the hippocampus in chronic epilepsy: seizures do not inevitably cause neuronal loss
    Maria Thom
    Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College, London, UK
    Brain 128:1344-57. 2005
    ..In conclusion, seizures do not invariably lead to hippocampal injury and white matter heterotopia is not invariably associated with hippocampal sclerosis...
  14. pmc Bilateral reorganization of the dentate gyrus in hippocampal sclerosis: a postmortem study
    M Thom
    Department of Clinical and Experimental Epilepsy, Division of Neuropathology, Institute of Neurology, Queen Square, London, UK
    Neurology 73:1033-40. 2009
    ..We aimed to investigate patterns of hippocampal abnormalities in a postmortem series as identified by NPY and dynorphin immunohistochemistry...
  15. ncbi request reprint Distribution of cortical interneurons in grey matter heterotopia in patients with epilepsy
    Maria Thom
    Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, London, United Kingdom
    Epilepsia 45:916-23. 2004
    ..We aimed to identify the subtypes and localisation of interneurons within grey matter heterotopia relative to cortex...
  16. ncbi request reprint Cajal-Retzius cells, inhibitory interneuronal populations and neuropeptide Y expression in focal cortical dysplasia and microdysgenesis
    M Thom
    Department of Clinical and Experimental Epilepsy, Division of Neuropathology, Institute of Neurology, Queen Square, WC1N 3BG, London, UK
    Acta Neuropathol 105:561-9. 2003
    ....
  17. ncbi request reprint Bilateral isolated hippocampal malformation in temporal lobe epilepsy
    M Thom
    Department of Clinical and Esperimental Epilepsy, Institute of Neurology, National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, United Kingdom
    Neurology 58:1683-6. 2002
    ..Postmortem examination revealed abnormal position and complex convolutional malformations isolated to the hippocampal formation in an adult with temporal lobe epilepsy in whom MRI demonstrated bilateral hippocampal abnormalities...
  18. ncbi request reprint An investigation of the expression of G1-phase cell cycle proteins in focal cortical dysplasia type IIB
    Maria Thom
    Department of Clinical and Experimental Epilepsy, Division of Neuropathology, Institute of Neurology, National Hospital for Neurology and Neurosurgery, Queen Square, London, UK
    J Neuropathol Exp Neurol 66:1045-55. 2007
    ..These findings also suggest that dysregulation of cell cycle pathways may occur in focal cortical dysplasia, which opens further areas for exploration as potential new treatment avenues...
  19. ncbi request reprint Mcm2 labelling of balloon cells in focal cortical dysplasia
    M Thom
    Department of Clinical and Experimental Epilepsy, Institute of Neurology, London, UK
    Neuropathol Appl Neurobiol 31:580-8. 2005
    ..Furthermore, as Mcm2 specifically identifies BC populations, this marker may be of diagnostic value in the subtyping of FCD lesions in patients with epilepsy...
  20. ncbi request reprint Balloon cells associated with granule cell dispersion in the dentate gyrus in hippocampal sclerosis
    M Thom
    Department of Clinical and Experimental Epilepsy, Institute of Neurology and National Hospital for Neurology and Neurosurgery, Queen Square, London, WC1N 3BG, UK
    Acta Neuropathol 115:697-700. 2008
    ..This observation opens up the debate regarding the origin of balloon cells and CD34 expression and their temporal relationship to seizures...
  21. doi request reprint Hippocampal sclerosis: progress since Sommer
    Maria Thom
    University College London, Institute of Neurology, Division of Neuropathology, London, UK
    Brain Pathol 19:565-72. 2009
    ....
  22. ncbi request reprint Microdysgenesis in temporal lobe epilepsy. A quantitative and immunohistochemical study of white matter neurones
    M Thom
    Department of Neuropathology, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
    Brain 124:2299-309. 2001
    ..These findings suggest that microdysgenesis may be a significant lesion in temporal lobe epilepsy in terms of post-surgical prognosis...
  23. ncbi request reprint Recent advances in the neuropathology of focal lesions in epilepsy
    Maria Thom
    National Hospital for Neurology and Neurosurgery, Queen Square, London, WC1N 3BG, UK
    Expert Rev Neurother 4:973-84. 2004
    ..The important contribution of astrocytes to epileptogenesis is also unfolding and is briefly discussed, as are the possible cellular mechanisms of drug resistance...
  24. ncbi request reprint Drug resistance in epilepsy: human epilepsy
    S M Sisodiya
    University Department of Clinical Neurology, Institute of Neurology, University College London, UK
    Novartis Found Symp 243:167-74; discussion 174-9, 180-5. 2002
    ..The timing shows that expression may be constitutive in some pathologies. These findings suggest that drug resistance proteins may contribute to drug resistance in refractory epilepsy...
  25. pmc Quantitative grey matter histological measures do not correlate with grey matter probability values from in vivo MRI in the temporal lobe
    S H Eriksson
    Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, London WC1N3BG, UK
    J Neurosci Methods 181:111-8. 2009
    ....
  26. ncbi request reprint Persistent reelin-expressing Cajal-Retzius cells in polymicrogyria
    S H Eriksson
    The National Society for Epilepsy and Epilepsy Research Group, University Department of Clinical Neurology, University College London, UK
    Brain 124:1350-61. 2001
    ....
  27. pmc Correlation of quantitative MRI and neuropathology in epilepsy surgical resection specimens--T2 correlates with neuronal tissue in gray matter
    S H Eriksson
    Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, Queen Square, Box 29, London WC1N 3BG, UK
    Neuroimage 37:48-55. 2007
    ..This will enable better identification and delineation of the structural causes of refractory focal epilepsy, and will be of particular benefit in patients in whom current optimal MRI does not identify a relevant abnormality...
  28. ncbi request reprint Drug resistance in epilepsy: expression of drug resistance proteins in common causes of refractory epilepsy
    S M Sisodiya
    Epilepsy Research Group, University Department of Clinical Neurology, University College London, London, UK
    Brain 125:22-31. 2002
    ..We propose that overexpressed resistance proteins lower the interstitial concentration of AEDs in the vicinity of the epileptogenic pathology and thereby render the epilepsy caused by these pathologies resistant to treatment with AEDs...
  29. ncbi request reprint Expression patterns of glial fibrillary acidic protein (GFAP)-delta in epilepsy-associated lesional pathologies
    L Martinian
    Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College, London, UK
    Neuropathol Appl Neurobiol 35:394-405. 2009
    ..The aim of this study was to investigate its expression in common causes of lesion-related refractory epilepsy...
  30. ncbi request reprint Vascular colocalization of P-glycoprotein, multidrug-resistance associated protein 1, breast cancer resistance protein and major vault protein in human epileptogenic pathologies
    S M Sisodiya
    Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, London WC1N 3BG, UK
    Neuropathol Appl Neurobiol 32:51-63. 2006
    ....
  31. ncbi request reprint Microdysgenesis with abnormal cortical myelinated fibres in temporal lobe epilepsy: a histopathological study with calbindin D-28-K immunohistochemistry
    M Thom
    Department of Neuropathology, Institute of Neurology, London, UK
    Neuropathol Appl Neurobiol 26:251-7. 2000
    ..In addition, prominent numbers of neurogliaform calbindin-positive nerve cells were observed in the microdysgenesis cases and the nature of these cells is speculated upon...
  32. ncbi request reprint Neocortical abnormalities of [11C]-flumazenil PET in mesial temporal lobe epilepsy
    A Hammers
    National Society for Epilepsy and Institute of Neurology, Queen Square, London
    Neurology 56:897-906. 2001
    ..The finding of abnormalities in patients who were thought to have unilateral HS only based on MRI suggests that more widespread abnormalities are present in HS...
  33. ncbi request reprint Amygdala sclerosis in sudden and unexpected death in epilepsy
    M Thom
    Department of Neuropathology, National Hospital for Neurology and Neurosurgery, London, UK
    Epilepsy Res 37:53-62. 1999
    ....
  34. ncbi request reprint Cytoarchitectural abnormalities in hippocampal sclerosis
    Maria Thom
    Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College of London, United Kingdom
    J Neuropathol Exp Neurol 61:510-9. 2002
    ..Although a role for Cajal-Retzius cells is therefore not implicated in the mechanism of granule cell disorganization, their excess number may be indicative of underlying hippocampal maldevelopment in HS...
  35. ncbi request reprint Sulcogyral variation in NMDA receptor 2A/B subunit immunoreactivity in human brain
    S M Sisodiya
    Epilepsy Research Group, University Department of Clinical Neurology, University College London, UK
    Neuroreport 11:2601-6. 2000
    ..Neurofilament and calretinin immunoreactivity do not show this phenomenon. The findings suggest novel functional regionalization at the sulcogyral level in normal human brain...
  36. ncbi request reprint Methodological aspects of 3D and automated 2D analyses of white matter neuronal density in temporal lobe epilepsy
    S H Eriksson
    Department of Clinical and Experimental Epilepsy, National Society for Epilepsy, London, UK
    Neuropathol Appl Neurobiol 32:260-70. 2006
    ..These findings have implications for studies requiring neuronal counts in normal and disease states...
  37. pmc Infundibulohypophysitis in a man presenting with diabetes insipidus and cavernous sinus involvement
    N Tubridy
    National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK
    J Neurol Neurosurg Psychiatry 71:798-801. 2001
    ..The diagnosis of infundibulohypophysitis was made on histological evidence. The patient was treated with prednisolone and methotrexate. At 9 months he is well, without symptoms, and the radiological abnormalities have resolved...
  38. pmc Relapsing intracranial Rosai-Dorfman disease
    A Petzold
    Department of Neuroimmunology, Institute of Neurology, Queen Square, London WC1N 3BG and Moorfields Eye Hospital, City Road, London EC1 2PD, UK
    J Neurol Neurosurg Psychiatry 71:538-41. 2001
    ..Review of the literature on intracranial Rosai-Dorfman disease leads to the suggestion that postoperative radiotherapy may be advisable in all cases...
  39. pmc PROPELLER MRI visualizes detailed pathology of hippocampal sclerosis
    Sofia H Eriksson
    Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, London, UK
    Epilepsia 49:33-9. 2008
    ..The aim of the current report was to explore PROPELLER image quality of the hippocampus compared to routine sequences...
  40. doi request reprint Calbindin D28K expression in relation to granule cell dispersion, mossy fibre sprouting and memory impairment in hippocampal sclerosis: a surgical and post mortem series
    L Martinian
    Department of Clinical and Experimental Epilepsy, Division of Neuropathology, UCL, Institute of Neurology and National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK
    Epilepsy Res 98:14-24. 2012
    ..The functional significance of CB loss, in terms of epileptogenesis and effects on memory, remain uncertain...
  41. ncbi request reprint Bilateral hippocampal granule cell dispersion: autopsy study of 3 infants
    B Harding
    Great Ormond Street Hospital for Children and National Hospital for Neurology and Neurosurgery, London, UK
    Neuropathol Appl Neurobiol 27:245-51. 2001
    ..The present observations bring into question the hypothesis that GCD is causally related to seizure activity in early life, suggesting an opposing view that it is an independent developmental disorder...
  42. ncbi request reprint Deregulation of cdk5 in Hippocampal sclerosis
    Arjune Sen
    Department of Clinical and Experimental Epilepsy, The Institute of Neurology, University College London, Queen Square, London, U K
    J Neuropathol Exp Neurol 65:55-66. 2006
    ..Our results suggest that p25 is pathologically increased in HS and that deregulation of cdk5 by p25 might contribute to neuronal death in this condition...
  43. ncbi request reprint Lack of support for a role for RLIP76 (RALBP1) in response to treatment or predisposition to epilepsy
    Nicole Soranzo
    Department of Clinical and Experimental Epilepsy, Institute of Neurology, UCL, London, UK
    Epilepsia 48:674-83. 2007
    ..Knowledge of which transporters may be critical in drug resistance is important for design of potential therapies. We tested the hypothesis that RLIP76 mediates AED resistance using methods complementary to those in the original report...
  44. ncbi request reprint The neuropathology of paraneoplastic syndromes
    F Scaravilli
    Department of Neuropathology, Institute of Neurology, The National Hospital Queen Square, London, UK
    Brain Pathol 9:251-60. 1999
    ..The Lambert-Eaton myasthenic syndrome will be dealt with separately in another paper in this symposium...
  45. ncbi request reprint The potential role of cyclin-dependent kinase 5 in focal cortical dysplasia
    Arjune Sen
    Department of Clinical and Experimental Epilepsy, University College London, London, UK
    Dev Neurosci 30:96-104. 2008
    ....
  46. pmc Cortical neuronal loss and hippocampal sclerosis are not detected by voxel-based morphometry in individual epilepsy surgery patients
    Sofia H Eriksson
    Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, London WC1N3BG, United Kingdom
    Hum Brain Mapp 30:3351-60. 2009
    ..This suggests that the methodology may currently not be suitable to detect particular occult abnormalities possibly associated with seizure onset zone in individual epilepsy patients with unremarkable standard structural MRI...
  47. pmc In vivo monitoring of neuronal loss in traumatic brain injury: a microdialysis study
    Axel Petzold
    Department of Neuroimmunology, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK
    Brain 134:464-83. 2011
    ....
  48. ncbi request reprint Immunolabeling recovery in archival, post-mortem, human brain tissue using modified antigen retrieval and the catalyzed signal amplification system
    Joan Y W Liu
    Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology and National Hospital for Neurology and Neurosurgery, 33 Queen Square, London WC1N 3BG, UK
    J Neurosci Methods 190:49-56. 2010
    ..Importantly, this study provides a method of overcoming formalin-masking of antigens in long-fixed human tissue, thus allowing essential immunohistochemical studies to be undertaken using precious human tissue...
  49. ncbi request reprint Focal cortical dysplasia type II: biological features and clinical perspectives
    Sanjay M Sisodiya
    Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, Queen Square, London, UK
    Lancet Neurol 8:830-43. 2009
    ....
  50. ncbi request reprint Major vault protein, a marker of drug resistance, is upregulated in refractory epilepsy
    Sanjay M Sisodiya
    Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, England
    Epilepsia 44:1388-96. 2003
    ..Other proteins associated with resistance in cancer include major vault protein (MVP) and breast cancer resistance protein (BCRP). We hypothesized that these proteins would also be upregulated in human epileptogenic pathologies...
  51. ncbi request reprint Widespread upregulation of drug-resistance proteins in fatal human status epilepticus
    Sanjay M Sisodiya
    Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, London, England
    Epilepsia 44:261-4. 2003
    ..We wished to determine if status epilepticus might cause upregulation of these proteins...
  52. ncbi request reprint Synergism between topiramate and budipine in refractory status epilepticus in the rat
    Andrew Fisher
    Department of Clinical and Experimental Epilepsy, Institute of Neurology, UCL, London, United Kingdom
    Epilepsia 45:1300-7. 2004
    ..To evaluate the antiepileptic and neuroprotective properties of topiramate (TPM) alone and with coadministration of the N-methyl-D-aspartate (NMDA)-receptor antagonist budipine in a rat model of refractory status epilepticus...
  53. ncbi request reprint Reliable registration of preoperative MRI with histopathology after temporal lobe resections
    Sofia H Eriksson
    Department of Clinical and Experimental Epilepsy, National Society for Epilepsy, United Kingdom
    Epilepsia 46:1646-53. 2005
    ..We have developed a method to facilitate registration of preoperative MRI with the resected specimen and to enable correlation of MRI findings with histopathology...
  54. ncbi request reprint Abnormal expression of cdk5 in focal cortical dysplasia in humans
    Sanjay M Sisodiya
    Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
    Neurosci Lett 328:217-20. 2002
    ..Here we examine eight cases of human FCD for expression of cdk5. We show abnormal cdk5 immunoreactivity and aggregation of protein suggesting alterations in cdk5 may also be involved in this important epileptogenic human pathology...
  55. ncbi request reprint Mitochondrial dysfunction associated with neuronal death following status epilepticus in rat
    Hannah R Cock
    Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, Queen Square, WC1N 3BG, London, UK
    Epilepsy Res 48:157-68. 2002
    ..The pattern of abnormalities is consistent with reversible mechanisms being involved in excitotoxic cell damage. This, together with the timing of changes, suggests new avenues for therapeutic intervention...
  56. ncbi request reprint Brain biopsy in dementia
    J D Warren
    Dementia Research Centre, Institute of Neurology, London, UK
    Brain 128:2016-25. 2005
    ....
  57. ncbi request reprint Increased immunoreactivity of cdk5 activators in hippocampal sclerosis
    Arjune Sen
    Department of Clinical and Experimental Epilepsy, Division of Neuropathology, Institute of Neurology, University College London, UK
    Neuroreport 18:511-6. 2007
    ..Our findings suggest that deregulation of cyclin-dependent kinase 5 might contribute to the pathogenesis of hippocampal sclerosis...
  58. ncbi request reprint Hippocampal malformations do not necessarily evolve into hippocampal sclerosis
    Arjune Sen
    Department of Clinical and Experimental Epilepsy, The Institute of Neurology, University College London, London, England
    Epilepsia 46:939-43. 2005
    ..We seek to address, in patients with recurrent convulsive seizures over many decades, whether hippocampal malformations necessarily progress to hippocampal sclerosis...
  59. ncbi request reprint Balloon cells in human cortical dysplasia and tuberous sclerosis: isolation of a pathological progenitor-like cell
    Shireena A Yasin
    Department of Histopathology, Great Ormond Street Hospital, London, UK
    Acta Neuropathol 120:85-96. 2010
    ..We have characterised the immunohistochemical, morphological and ultrastructural features of these cells. This is the first isolation of an abnormal cell with features of a progenitor/stem cell from a non-neoplastic disease of the brain...
  60. ncbi request reprint Pathological tau tangles localize to focal cortical dysplasia in older patients
    Arjune Sen
    Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, Queen Square, London, UK
    Epilepsia 48:1447-54. 2007
    ..We therefore hypothesized that the developmentally abnormal cortex of FCD might be more susceptible to tau-mediated neurodegeneration than adjacent histologically normal cortex...
  61. ncbi request reprint Increased NKCC1 expression in refractory human epilepsy
    Arjune Sen
    Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, United Kingdom
    Epilepsy Res 74:220-7. 2007
    ..Our results suggest that NKCC1 might contribute to the pathogenesis or pathophysiology of HS and FCD, thereby potentially offering a new therapeutic target in the treatment of pharmacoresistant epilepsy...
  62. ncbi request reprint Abnormalities of grey and white matter [11C]flumazenil binding in temporal lobe epilepsy with normal MRI
    A Hammers
    MRC Clinical Sciences Centre and Division of Neuroscience, Faculty of Medicine, Imperial College, London, UK
    Brain 125:2257-71. 2002
    ..Furthermore, increases in FMZ binding in TLWM, indicating microdysgenesis, were detected in the majority of these patients and may represent the structural basis of their epilepsy...
  63. ncbi request reprint Doublecortin expression in focal cortical dysplasia in epilepsy
    Nisaharan Srikandarajah
    Department of Clinical and Experimental Epilepsy, Institute of Neurology, Queen Square, London, United Kingdom
    Epilepsia 50:2619-28. 2009
    ..The aim was to study DCX expression patterns in such lesions compared to normal developing and mature cortex...
  64. pmc Genetic predictors of the maximum doses patients receive during clinical use of the anti-epileptic drugs carbamazepine and phenytoin
    Sarah K Tate
    Department of Biology, University College London, Darwin Building, Gower Street, London WC1E 6BT, United Kingdom
    Proc Natl Acad Sci U S A 102:5507-12. 2005
    ..Although the case made here is compelling, our results cannot be considered definitive or ready for clinical application until they are confirmed by independent replication...
  65. ncbi request reprint Tonic GABA(A) receptor-mediated currents in human brain
    Annalisa Scimemi
    Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
    Eur J Neurosci 24:1157-60. 2006
    ..These tonic currents have cell type-specific pharmacologies, opening up the possibility of targeted therapeutics...
  66. doi request reprint A comparative study of the dentate gyrus in hippocampal sclerosis in epilepsy and dementia
    R Bandopadhyay
    Department of Clinical and Experimental Epilepsy, UCL, Institute of Neurology and National Hospital for Neurology and Neurosurgery, London, UK
    Neuropathol Appl Neurobiol 40:177-90. 2014
    ..We sought to compare the pathology of HSE and HSD , focusing on re-organization in the dentate gyrus...
  67. ncbi request reprint Aggressive CNS lupus vasculitis in the absence of systemic disease activity
    C M Everett
    Department of Molecular Neuroscience and Centre for Neuromuscular Disease, Institute of Neurology and The National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK
    Rheumatology (Oxford) 47:107-9. 2008
  68. ncbi request reprint Progesterone receptors are expressed with higher frequency by optic nerve sheath meningiomas
    M Thom
    Department of Neuropathology, National Hospital for Neurology and Neurosurgery, Queen Square, London, United Kingdom
    Clin Neuropathol 21:5-8. 2002
    ....
  69. ncbi request reprint Unihemispheric cerebral vasculitis mimicking Rasmussen's encephalitis
    C Derry
    Department of Neuroinflammation, Institute of Neurology, Queen Square, London, UK
    Neurology 58:327-8. 2002
  70. pmc Mesial temporal lobe epilepsy: How do we improve surgical outcome?
    Maria Thom
    Institute of Neurology, National Hospital for Neurology and Neurosurgery, University College London, London, UK
    Ann Neurol 68:424-34. 2010
    ..That recognition may lead to identifying the appropriate subgroups that will require different diagnostic and surgical approaches to improve surgical outcomes...
  71. ncbi request reprint Diffusion tensor imaging in refractory epilepsy
    Fergus J Rugg-Gunn
    MRI Unit, National Society for Epilepsy and Research Department of Clinical and Experimental Epilepsy, Institute of Neurology, London, UK
    Lancet 359:1748-51. 2002
    ..Histopathological examination of the resected tissue showed gliosis. Our findings may affect the investigation of similar patients, and provide histopathological confirmation of diffusion abnormalities...
  72. ncbi request reprint Ammon's horn sclerosis: a maldevelopmental disorder associated with temporal lobe epilepsy
    Ingmar Blumcke
    Department of Neuropathology, University of Bonn Medical Center, Germany
    Brain Pathol 12:199-211. 2002
    ..Its association with a lowered seizure threshold and an increased susceptibility for segmental cell loss in the hippocampus during the long course of the disease may constitute additional elements in a pathogenic cascade...
  73. ncbi request reprint Quantitative neuropathology of the entorhinal cortex region in patients with hippocampal sclerosis and temporal lobe epilepsy
    Stephen Dawodu
    Division of Neuropathology and Department of Clinical and Experimental Epilepsy, National Hospital for Neurology and Neurosurgery and Institute of Neurology, London, England
    Epilepsia 46:23-30. 2005
    ..Few neuropathologic studies of this region have been undertaken in patients with HS undergoing surgery, some suggesting preferential loss of layer III neurones...
  74. ncbi request reprint Microdysgenesis in mesial temporal lobe epilepsy
    Sofia H Eriksson
    Ann Neurol 55:596-7; author reply 597. 2004