Research Topics
Genomes and GenesSpecies | Evropi TheodoratouSummaryAffiliation: University of Edinburgh Country: UK Publications
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Publications
Dietary flavonoids and the risk of colorectal cancerEvropi Theodoratou
Public Health Sciences, College of Medicine and Vet Medicine, University of Edinburgh, Edinburgh, United Kingdom
Cancer Epidemiol Biomarkers Prev 16:684-93. 2007..22), and phytoestrogens (P(trend) = 0.26). This was the first of several a priori hypotheses to be tested in this large study and showed strong and linear inverse associations of flavonoids with colorectal cancer risk...
Dietary vitamin B6 intake and the risk of colorectal cancerEvropi Theodoratou
Public Health Sciences, College of Medicine and Vet Medicine, University of Edinburgh, Edinburgh, United Kingdom
Cancer Epidemiol Biomarkers Prev 17:171-82. 2008..Evidence from larger cohort and experimental studies is now required to confirm and define the anticarcinogenic actions of vitamin B6 and to explore the mechanisms by which this effect is mediated...
Modification of the associations between lifestyle, dietary factors and colorectal cancer risk by APC variantsEvropi Theodoratou
Public Health Sciences, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, UK
Carcinogenesis 29:1774-80. 2008..However, further large-scale studies are necessary in order to replicate these findings and confirm the role of these APC gene variants and their interaction with dietary and lifestyle exposures in colorectal carcinogenesis...
Preventive zinc supplementation in developing countries: impact on mortality and morbidity due to diarrhea, pneumonia and malariaMohammad Yawar Yakoob
Division of Women and Child Health, The Aga Khan University, Karachi, Pakistan
BMC Public Health 11:S23. 2011....
Ten common genetic variants associated with colorectal cancer risk are not associated with survival after diagnosisAlbert Tenesa
Colon Cancer Genetics Group and Academic Coloproctology, Institute of Genetics and Molecular Medicine, Western General Hospital Edinburgh, University of Edinburgh and MRC Human Genetics Unit, Edinburgh, United Kingdom
Clin Cancer Res 16:3754-9. 2010..To date, genomewide association studies have identified 10 genetic loci associated with colorectal cancer (CRC) susceptibility. We hypothesized that these loci might also affect cancer survival...
The association of dietary intake of purine-rich vegetables, sugar-sweetened beverages and dairy with plasma urate, in a cross-sectional studyLina Zgaga
Centre for Population Health Sciences, University of Edinburgh, Edinburgh, United Kingdom
PLoS ONE 7:e38123. 2012..Objective of this study was to investigate the association between plasma urate concentration and: a) food items: dairy, sugar-sweetened beverages (SSB) and purine-rich vegetables; b) related nutrients: lactose, calcium and fructose...
Association between common mtDNA variants and all-cause or colorectal cancer mortalityEvropi Theodoratou
Public Health Sciences, College of Medicine and Veterinary Medicine, University of Edinburgh, Edinburgh, UK
Carcinogenesis 31:296-301. 2010..These findings are interesting and consistent with other biological knowledge but need to be confirmed through replication in independent cohorts...
Modification of the inverse association between dietary vitamin D intake and colorectal cancer risk by a FokI variant supports a chemoprotective action of Vitamin D intake mediated through VDR bindingEvropi Theodoratou
Public Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, United Kingdom
Int J Cancer 123:2170-9. 2008..70, 95% CI 0.56, 0.87). The evidence of interaction we report here further supports the inverse association between vitamin D mediated through binding to the VDR...
Instrumental variable estimation of the causal effect of plasma 25-hydroxy-vitamin D on colorectal cancer risk: a mendelian randomization analysisEvropi Theodoratou
Centre for Population Health Sciences, University of Edinburgh, Edinburgh, United Kingdom
PLoS ONE 7:e37662. 2012..To elucidate the effect of vitamin D on CRC cancer risk, additional large studies of vitamin D and CRC risk are required and/or the application of alternative methods that are less sensitive to weak instrument restrictions...
Dietary fatty acids and colorectal cancer: a case-control studyEvropi Theodoratou
Public Health Sciences, University of Edinburgh, Edinburgh, United Kingdom
Am J Epidemiol 166:181-95. 2007..The observed different effects of different types of fatty acids underline the importance of type of fat in the etiology and prevention of colorectal cancer...
Diet, environmental factors, and lifestyle underlie the high prevalence of vitamin D deficiency in healthy adults in Scotland, and supplementation reduces the proportion that are severely deficientLina Zgaga
Centre for Population Health Sciences, University of Edinburgh, Edinburgh EH8 9AG, UK
J Nutr 141:1535-42. 2011....
Statin use and association with colorectal cancer survival and risk: case control study with prescription data linkageFatim Lakha
Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, UK
BMC Cancer 12:487. 2012..Epidemiological studies have reported conflicting associations between statins and CRC risk and there is one published report of the association between statins and CRC survival...
Abundant pleiotropy in human complex diseases and traitsShanya Sivakumaran
Centre for Population Health Sciences, The University of Edinburgh, Edinburgh EH8 9AG, UK
Am J Hum Genet 89:607-18. 2011....
Estimating pneumonia deaths of post-neonatal children in countries of low or no death certification in 2008Evropi Theodoratou
Centre for Population Health Sciences, University of Edinburgh Medical School, Edinburgh, United Kingdom
PLoS ONE 6:e25095. 2011....
Systematic meta-analyses and field synopsis of genetic association studies in colorectal cancerEvropi Theodoratou
Centre for Population Health Sciences, University of Edinburgh, UK
J Natl Cancer Inst 104:1433-57. 2012..chs.med.ed.ac.uk/CRCgene/)...
Optimizing community case management strategies to achieve equitable reduction of childhood pneumonia mortality: An application of Equitable Impact Sensitive Tool (EQUIST) in five low- and middle-income countriesDonald Waters
Centre for Population Health Sciences and Global Health Academy, The University of Edinburgh Medical School, Edinburgh, Scotland, UK
J Glob Health 2:20402. 2012....
Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer riskMalcolm G Dunlop
Colon Cancer Genetics Group, Institute of Genetics and Molecular Medicine, University of Edinburgh and Medical Research Council MRC Human Genetics Unit, Edinburgh, UK
Nat Genet 44:770-6. 2012..2 (rs5934683, near SHROOM2; P = 7.30 × 10(-10)) This brings the number of independent loci associated with CRC risk to 20 and provides further insight into the genetic architecture of inherited susceptibility to CRC...
Setting research priorities to reduce global mortality from childhood pneumonia by 2015Igor Rudan
Centre for Population Health Sciences, The University of Edinburgh Medical School, Edinburgh, Scotland, United Kingdom
PLoS Med 8:e1001099. 2011..Igor Rudan and colleagues report the results of their consensus building exercise that identified health research priorities to help reduce child mortality from pneumonia...
Global burden of respiratory infections due to seasonal influenza in young children: a systematic review and meta-analysisHarish Nair
Centre for Population Health Sciences, Global Health Academy, The University of Edinburgh, Edinburgh, UK
Lancet 378:1917-30. 2011..We aimed to estimate the global incidence of and mortality from lower respiratory infections associated with influenza in children younger than 5 years...
An evaluation of oxygen systems for treatment of childhood pneumoniaAlastair G Catto
Centre for Population Health Sciences, College of Medicine and Veterinary Medicine, University of Edinburgh, UK
BMC Public Health 11:S28. 2011..This review aims to assess the utility of oxygen systems as a method for reducing childhood mortality from pneumonia...
The effect of Haemophilus influenzae type b and pneumococcal conjugate vaccines on childhood pneumonia incidence, severe morbidity and mortalityEvropi Theodoratou
Public Health Sciences, University of Edinburgh, Edinburgh, UK
Int J Epidemiol 39:i172-85. 2010....
Estimating the incidence of colorectal cancer in Sub-Saharan Africa: A systematic analysisAlice Graham
Centre for Population Health Sciences and Global Health Academy, The University of Edinburgh Medical School, Edinburgh, Scotland, UK
J Glob Health 2:20404. 2012..This study analyses the data available to produce an estimate of the incidence of colorectal cancer in Sub-Saharan Africa (SSA)...
