S A Teichmann

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. ncbi request reprint Immunoglobulin superfamily proteins in Caenorhabditis elegans
    S A Teichmann
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, UK
    J Mol Biol 296:1367-83. 2000
  2. pmc Uncovering the interplay between DNA sequence preferences of transcription factors and nucleosomes
    Sarah A Teichmann
    MRC Laboratory of Molecular Biology Cambridge, UK
    Cell Cycle 11:4487-8. 2012
  3. pmc DNA sequence preferences of transcriptional activators correlate more strongly than repressors with nucleosomes
    Varodom Charoensawan
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
    Mol Cell 47:183-92. 2012
  4. pmc Cellular crowding imposes global constraints on the chemistry and evolution of proteomes
    Emmanuel D Levy
    Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom
    Proc Natl Acad Sci U S A 109:20461-6. 2012
  5. pmc Lineage-specific expansion of DNA-binding transcription factor families
    Varodom Charoensawan
    MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK
    Trends Genet 26:388-93. 2010
  6. pmc How do proteins gain new domains?
    Joseph A Marsh
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, UK
    Genome Biol 11:126. 2010
  7. pmc The developmental expression dynamics of Drosophila melanogaster transcription factors
    Boris Adryan
    Computational Biology Group, Structural Studies Division, MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Genome Biol 11:R40. 2010
  8. pmc Functional protein divergence in the evolution of Homo sapiens
    Nuria Lopez-Bigas
    Research Unit on Biomedical Informatics, Experimental and Health Science Department, Universitat Pompeu Fabra, Barcelona, 08003, Spain
    Genome Biol 9:R33. 2008
  9. pmc Evolution of protein complexes by duplication of homomeric interactions
    Jose B Pereira-Leal
    Instituto Gulbenkian de Ciencia, Apartado 14, Oeiras, Portugal
    Genome Biol 8:R51. 2007
  10. pmc Patterns of evolutionary constraints on genes in humans
    Subhajyoti De
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, UK
    BMC Evol Biol 8:275. 2008

Detail Information

Publications68

  1. ncbi request reprint Immunoglobulin superfamily proteins in Caenorhabditis elegans
    S A Teichmann
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, UK
    J Mol Biol 296:1367-83. 2000
    ..elegans, a framework for refinement and extension of the repertoire as gene and protein definitions improve, and the basis for investigations of their function and for comparisons with the repertoires of other organisms...
  2. pmc Uncovering the interplay between DNA sequence preferences of transcription factors and nucleosomes
    Sarah A Teichmann
    MRC Laboratory of Molecular Biology Cambridge, UK
    Cell Cycle 11:4487-8. 2012
    ..Comment on: Charoensawan V, et al. Mol Cell 2012; 47:183-92...
  3. pmc DNA sequence preferences of transcriptional activators correlate more strongly than repressors with nucleosomes
    Varodom Charoensawan
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
    Mol Cell 47:183-92. 2012
    ..Consistent with this, we show that activators induce more nucleosome disruption upon transcriptional activation than repressors...
  4. pmc Cellular crowding imposes global constraints on the chemistry and evolution of proteomes
    Emmanuel D Levy
    Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom
    Proc Natl Acad Sci U S A 109:20461-6. 2012
    ..Remarkably, the effects observed are consistently larger in E. coli and S. cerevisiae than in H. sapiens, suggesting that promiscuous protein-protein interactions may be freer to accumulate in the human lineage...
  5. pmc Lineage-specific expansion of DNA-binding transcription factor families
    Varodom Charoensawan
    MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK
    Trends Genet 26:388-93. 2010
    ..We found only three out of 131 (2%) DBD families shared by the three superkingdoms...
  6. pmc How do proteins gain new domains?
    Joseph A Marsh
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, UK
    Genome Biol 11:126. 2010
    ..A study of the contributions of different mechanisms of domain gain in animal proteins suggests that gene fusion is likely to be most frequent...
  7. pmc The developmental expression dynamics of Drosophila melanogaster transcription factors
    Boris Adryan
    Computational Biology Group, Structural Studies Division, MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Genome Biol 11:R40. 2010
    ..Their binding to cis-regulatory modules of target genes mediates the precise cell- and context-specific activation and repression of genes. The expression of TFs should therefore reflect the core expression program of each cell...
  8. pmc Functional protein divergence in the evolution of Homo sapiens
    Nuria Lopez-Bigas
    Research Unit on Biomedical Informatics, Experimental and Health Science Department, Universitat Pompeu Fabra, Barcelona, 08003, Spain
    Genome Biol 9:R33. 2008
    ..However, it is not well understood how this has given rise to the enormous diversity of metazoa present today...
  9. pmc Evolution of protein complexes by duplication of homomeric interactions
    Jose B Pereira-Leal
    Instituto Gulbenkian de Ciencia, Apartado 14, Oeiras, Portugal
    Genome Biol 8:R51. 2007
    ..The mechanisms driving the emergence and evolution of these modules are still unclear. Here we investigate the evolutionary origins of protein complexes, modules in physical protein-protein interaction networks...
  10. pmc Patterns of evolutionary constraints on genes in humans
    Subhajyoti De
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, UK
    BMC Evol Biol 8:275. 2008
    ..A strong or even moderate change in constraints in functional regions, for example in coding regions, can have significant evolutionary consequences...
  11. pmc Protein domain organisation: adding order
    Sarah K Kummerfeld
    Department of Developmental Biology, 279 Campus Dr, Stanford, 94305, CA, USA
    BMC Bioinformatics 10:39. 2009
    ..Recognising these patterns and unravelling how they have arisen may allow us to understand the functional relationships between domains and understand how the protein repertoire has evolved...
  12. ncbi request reprint Gene regulatory network growth by duplication
    Sarah A Teichmann
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Nat Genet 36:492-6. 2004
    ..In addition, we conclude that evolution has been incremental, rather than making entire regulatory circuits or motifs by duplication with inheritance of interactions...
  13. pmc Transcriptional networking
    Sarah A Teichmann
    Structural Studies Division, MRC Laboratory of Molecular Biology, Cambridge CB2 2QH, UK
    Genome Biol 6:344. 2005
  14. ncbi request reprint The constraints protein-protein interactions place on sequence divergence
    Sarah A Teichmann
    MRC Laboratory of Molecular Biology, Hills Road, CB2 2QH, Cambridge, UK
    J Mol Biol 324:399-407. 2002
    ..This trend is independent of whether the proteins are involved in informational functions (transcription, translation and replication) or not and of protein dispensability...
  15. ncbi request reprint Conservation of gene co-regulation in prokaryotes and eukaryotes
    Sarah A Teichmann
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Trends Biotechnol 20:407-10; discussion 410. 2002
    ..Our analysis reveals that the number of conserved co-regulated genes is small in eukaryotes, as has been shown previously in prokaryotes, indicating that there are extensive variations in the gene regulatory network across organisms...
  16. ncbi request reprint Fast assignment of protein structures to sequences using the intermediate sequence library PDB-ISL
    S A Teichmann
    MRC Laboratory of Molecular Biology, Cambridge, UK
    Bioinformatics 16:117-24. 2000
    ..A new approach using intermediate sequences was tested as a shortcut to iterative multiple sequence search methods such as PSI-BLAST...
  17. ncbi request reprint Is there a phylogenetic signal in prokaryote proteins?
    S A Teichmann
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    J Mol Evol 49:98-107. 1999
    ....
  18. ncbi request reprint Advances in structural genomics
    S A Teichmann
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, UK
    Curr Opin Struct Biol 9:390-9. 1999
    ..These assignments give a new perspective on domain structures, gene duplications, protein families and protein folds in genome sequences...
  19. ncbi request reprint The evolution and structural anatomy of the small molecule metabolic pathways in Escherichia coli
    S A Teichmann
    Department of Biochemistry and Molecular Biology, University College London, Darwin Building, Gower Street, London, WC1E 6BT, UK
    J Mol Biol 311:693-708. 2001
    ..Most of the domains that form SMM pathways have homologues in non-SMM pathways. Taken together, these results imply a pervasive "mosaic" model for the formation of protein repertoires and pathways...
  20. ncbi request reprint Small-molecule metabolism: an enzyme mosaic
    S A Teichmann
    Dept of Biochemistry and Molecular Biology, University College London, Darwin Building, Gower Street, WC1E 6BT, London, UK
    Trends Biotechnol 19:482-6. 2001
    ..This is analogous to a mosaic in which a stone of a certain colour is selected to fill a position in the picture...
  21. pmc Structural assignments to the Mycoplasma genitalium proteins show extensive gene duplications and domain rearrangements
    S A Teichmann
    Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, United Kingdom
    Proc Natl Acad Sci U S A 95:14658-63. 1998
    ..The PDB domain matches also describe the domain structure of the matched sequences: just over a quarter contain one domain and the rest have combinations of two or more domains...
  22. ncbi request reprint Domain combinations in archaeal, eubacterial and eukaryotic proteomes
    G Apic
    Laboratory of Molecular Biology, MRC, Hills Road, Cambridge, CB2 2QH, UK
    J Mol Biol 310:311-25. 2001
    ..Finally, we compare the set of the domain combinations in the genomes to those in the RCSB Protein Data Bank, and discuss the implications for structural genomics...
  23. ncbi request reprint Evolution of the protein repertoire
    Cyrus Chothia
    Structural Studies Division, MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Science 300:1701-3. 2003
    ..Proteins of known structure can be matched to about 50% of genome sequences, and these data provide a quantitative description and can suggest hypotheses about the origins of these processes...
  24. ncbi request reprint Multi-domain protein families and domain pairs: comparison with known structures and a random model of domain recombination
    Gordana Apic
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    J Struct Funct Genomics 4:67-78. 2003
    ..Of particular interest are those combinations that occur in the largest number of multi-domain proteins, and several of these frequent novel combinations contain DNA-binding domains...
  25. ncbi request reprint Principles of protein-protein interactions
    Sarah A Teichmann
    MRC Laboratory of Molecular Biology, Cambridge, UK
    Bioinformatics 18:S249. 2002
    ..Given that all proteins consist of their evolutionary units, the domains, all interactions occur between these domains. The interactions between domains belonging to different protein families will be the second topic of my talk...
  26. ncbi request reprint Determination of protein function, evolution and interactions by structural genomics
    S A Teichmann
    Department of Biochemistry and Molecular Biology, University College London, Gower Street, WC1E 6BT, London, UK
    Curr Opin Struct Biol 11:354-63. 2001
    ....
  27. ncbi request reprint The transcriptional program controlled by the stem cell leukemia gene Scl/Tal1 during early embryonic hematopoietic development
    Nicola K Wilson
    University of Cambridge, Department of Haematology, Cambridge Institute for Medical Research, Cambridge, United Kingdom
    Blood 113:5456-65. 2009
    ....
  28. ncbi request reprint An insight into domain combinations
    G Apic
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, UK
    Bioinformatics 17:S83-9. 2001
    ..This type of pattern can be described by a scale-free network. Finally, we study domain repeats and we compare the set of the domain combinations in the genomes to those in PDB, and discuss the implications for structural genomics...
  29. pmc DBD--taxonomically broad transcription factor predictions: new content and functionality
    Derek Wilson
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 0QH, UK
    Nucleic Acids Res 36:D88-92. 2008
    ..Eukaryotes follow a slower rate of increase in TFs than prokaryotes, which could be due to the presence of splice variants or an increase in combinatorial control...
  30. pmc Assembly reflects evolution of protein complexes
    Emmanuel D Levy
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Nature 453:1262-5. 2008
    ..Our model of self-assembly allows reliable prediction of evolution and assembly of a complex solely from its crystal structure...
  31. pmc 3D complex: a structural classification of protein complexes
    Emmanuel D Levy
    Medical Research Council Laboratory of Molecular Biology, Cambridge, United Kingdom
    PLoS Comput Biol 2:e155. 2006
    ..Our classification, available as a database and Web server at http://www.3Dcomplex.org, will be a starting point for future work aimed at understanding the structure and evolution of protein complexes...
  32. ncbi request reprint Computational identification of site-specific transcription factors in Drosophila
    Boris Adryan
    Theoretical and Computational Biology, MRC Laboratory of Molecular Biology, Cambridge, UK lmb cam ac uk
    Fly (Austin) 1:142-5. 2007
    ..This article deals with the computational identification of TFs (how to find them in genomes) and with online resources such as the FlyTF database of Drosophila site-specific TFs (how to find them online)...
  33. pmc Tight regulation of unstructured proteins: from transcript synthesis to protein degradation
    Jörg Gsponer
    Medical Research Council MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
    Science 322:1365-8. 2008
    ..Fidelity in signaling may require that most IUPs be available in appropriate amounts and not present longer than needed...
  34. pmc The impact of genomic neighborhood on the evolution of human and chimpanzee transcriptome
    Subhajyoti De
    MRC Laboratory of Molecular Biology, Cambridge, UK
    Genome Res 19:785-94. 2009
    ..We propose that, in addition to other molecular mechanisms, change in genomic neighborhood is an important factor that drives transcriptome evolution...
  35. pmc Genomic repertoires of DNA-binding transcription factors across the tree of life
    Varodom Charoensawan
    MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK
    Nucleic Acids Res 38:7364-77. 2010
    ..As pointed out before, prokaryotic TFs increase faster than linearly. We further observe a similar relationship in eukaryotic genomes with a slower increase in TFs...
  36. pmc The impact of gene expression regulation on evolution of extracellular signaling pathways
    Varodom Charoensawan
    Medical Research Council Laboratory of Molecular Biology, Cambridge CB20QH, United Kingdom
    Mol Cell Proteomics 9:2666-77. 2010
    ..This allows homologous extracellular receptors to attain specialized functions and become specific to tissues and/or developmental stages...
  37. pmc EpiChIP: gene-by-gene quantification of epigenetic modification levels
    Daniel Hebenstreit
    MRC Laboratory of Molecular Biology, Hills Rd, CB2 0QH Cambridge, UK
    Nucleic Acids Res 39:e27. 2011
    ..We have developed a software package called EpiChIP that carries out this type of analysis, including integration with and visualization of gene expression data...
  38. pmc Networks for all
    Sebastian E Ahnert
    Theory of Condensed Matter Group, Cavendish Laboratory, University of Cambridge, JJ Thomson Avenue, Cambridge, UK
    Genome Biol 9:324. 2008
    ..A report on the Cold Spring Harbor Laboratory/Wellcome Trust conference on Network Biology, Hinxton, UK, 27-31 August 2008...
  39. ncbi request reprint Divergence of interdomain geometry in two-domain proteins
    Jung Hoon Han
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, United Kingdom
    Structure 14:935-45. 2006
    ..Variable interdomain geometries can be found in homologous structures with high sequence identities (70%)...
  40. ncbi request reprint FlyTF: a systematic review of site-specific transcription factors in the fruit fly Drosophila melanogaster
    Boris Adryan
    MRC Laboratory of Molecular Biology Cambridge CB2 2QH, UK
    Bioinformatics 22:1532-3. 2006
    ..We propose a set of 753 TFs in the fruit fly, of which 23 are confident novel predictions of this function for previously uncharacterized proteins...
  41. ncbi request reprint The relationship between domain duplication and recombination
    Christine Vogel
    MRC Laboratory of Molecular Biology, Hills Rd, Cambridge CB2 2QH, UK
    J Mol Biol 346:355-65. 2005
    ..Some of the pair-wise domain combinations that are highly duplicated also recur frequently with other partner domains, and thus represent evolutionary units larger than single protein domains, which we term "supra-domains"...
  42. ncbi request reprint Statistical analysis of domains in interacting protein pairs
    Tom M W Nye
    Medical Research Council Biostatistics Unit, Cambridge, UK
    Bioinformatics 21:993-1001. 2005
    ..Our approach is driven by the need to assess the evidence for physical contacts between domains in a statistically rigorous way...
  43. ncbi request reprint Structure and evolution of transcriptional regulatory networks
    M Madan Babu
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Curr Opin Struct Biol 14:283-91. 2004
    ..Interactions are conserved to varying degrees among genomes. Insights from the structure and evolution of these networks can be translated into predictions and used for engineering of the regulatory networks of different organisms...
  44. ncbi request reprint Supra-domains: evolutionary units larger than single protein domains
    Christine Vogel
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, UK
    J Mol Biol 336:809-23. 2004
    ..Since this is the case for only a quarter of the supra-domains, we provide a list of the most important unknown supra-domains as potential targets for structural genomics projects...
  45. ncbi request reprint Structure, function and evolution of multidomain proteins
    Christine Vogel
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Curr Opin Struct Biol 14:208-16. 2004
    ..Future work will require a domain-centric functional classification scheme and efforts to determine structures of domain combinations...
  46. ncbi request reprint Nuclear receptors: the evolution of diversity
    John W R Schwabe
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Sci STKE 2004:pe4. 2004
    ....
  47. ncbi request reprint The immunoglobulin superfamily in Drosophila melanogaster and Caenorhabditis elegans and the evolution of complexity
    Christine Vogel
    MRC Laboratory of Molecular Biology, Cambridge CB2 2QH, UK
    Development 130:6317-28. 2003
    ..These results suggest that the expansion of this protein superfamily is one of the factors that have contributed to the formation of the more complex physiological features that are found in Drosophila...
  48. pmc Evolution of transcription factors and the gene regulatory network in Escherichia coli
    M Madan Babu
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Nucleic Acids Res 31:1234-44. 2003
    ....
  49. ncbi request reprint Relative rates of gene fusion and fission in multi-domain proteins
    Sarah K Kummerfeld
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge, UK, CB2 2QH
    Trends Genet 21:25-30. 2005
    ..We found that fusion events are approximately four times more common than fission events, and we established that, in most cases, any particular fusion or fission event only occurred once during the course of evolution...
  50. pmc The origins and evolution of functional modules: lessons from protein complexes
    Jose B Pereira-Leal
    MRC Laboratory of Molecular Biology Hills Road, Cambridge CB2 2QH, UK
    Philos Trans R Soc Lond B Biol Sci 361:507-17. 2006
    ..We also provide a perspective on the evolutionary mechanisms driving the growth of other modular cellular networks such as transcriptional regulatory and metabolic networks...
  51. pmc DBD: a transcription factor prediction database
    Sarah K Kummerfeld
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Nucleic Acids Res 34:D74-81. 2006
    ..Users can browse, search or download the predictions by genome, domain family or sequence identifier, view families of transcription factors based on domain architecture and receive predictions for a protein sequence...
  52. ncbi request reprint Functional determinants of transcription factors in Escherichia coli: protein families and binding sites
    M Madan Babu
    MRC Laboratory of Molecular Biology, Hills Road, CB2 2QH, Cambridge, UK
    Trends Genet 19:75-9. 2003
    ....
  53. ncbi request reprint Evolutionary dynamics of prokaryotic transcriptional regulatory networks
    M Madan Babu
    National Center for Biotechnology Information, National Institutes of Health, MD 20894, USA
    J Mol Biol 358:614-33. 2006
    ..The methods for biological network analysis introduced here can be applied generally to study other networks, and these predictions can be used to guide specific experiments...
  54. pmc Novel specificities emerge by stepwise duplication of functional modules
    Jose B Pereira-Leal
    MRC Laboratory of Molecular Biology, Structural Studies Division, Cambridge CB2 2QH, United Kingdom
    Genome Res 15:552-9. 2005
    ..We show that duplicated complexes retain the same overall function, but have different binding specificities and regulation, revealing that duplication of these modules is associated with functional specialization...
  55. ncbi request reprint The folding and evolution of multidomain proteins
    Jung Hoon Han
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Nat Rev Mol Cell Biol 8:319-30. 2007
    ..Furthermore, recent studies indicate that multidomain proteins have evolved mechanisms to minimize the problems of interdomain misfolding...
  56. ncbi request reprint Homomeric protein complexes: evolution and assembly
    A J Venkatakrishnan
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Biochem Soc Trans 38:879-82. 2010
    ..Also, we briefly discuss the pathway of their assembly in solution...
  57. pmc Structure and distribution of pentapeptide repeats in bacteria
    A Bateman
    Medical Research Council Laboratory of Molecular Biology, Cambridge, United Kingdom
    Protein Sci 7:1477-80. 1998
    ..A structural model of the pentapeptide repeats is presented...
  58. ncbi request reprint Homology, pathway distance and chromosomal localization of the small molecule metabolism enzymes in Escherichia coli
    Stuart C G Rison
    Department of Biochemistry and Molecular Biology, University College London, Darwin Building, Gower Street, London WC1E 6BT, UK
    J Mol Biol 318:911-32. 2002
    ..SMM exploits regulatory strategies involving chromosomal location, isozymes and the reuse of enzymes...
  59. ncbi request reprint A census of human transcription factors: function, expression and evolution
    Juan M Vaquerizas
    EMBL European Bioinformatics Institute, Wellcome Trust Genome Campus, Cambridge, UK
    Nat Rev Genet 10:252-63. 2009
    ..Much remains to be explored, but this study provides a solid foundation for future investigations to elucidate regulatory mechanisms underlying diverse mammalian biological processes...
  60. pmc BloodExpress: a database of gene expression in mouse haematopoiesis
    Diego Miranda-Saavedra
    Department of Haematology, Cambridge Institute for Medical Research, University of Cambridge, Hills Road, Cambridge CB2 0XY, UK
    Nucleic Acids Res 37:D873-9. 2009
    ..BloodExpress thus constitutes a platform for the discovery of novel gene functions across the haematopoietic tree. BloodExpress is freely accessible at http://hscl.cimr.cam.ac.uk/bloodexpress/...
  61. pmc The (in)dependence of alternative splicing and gene duplication
    David Talavera
    Molecular Modeling and Bioinformatics Unit, Parc Cientific de Barcelona, Barcelona, Spain
    PLoS Comput Biol 3:e33. 2007
    ..We discuss possible explanations that relate to the order of appearance of AS and GD in a gene family, and to the selection pressure imposed by the environment...
  62. ncbi request reprint The importance of sequence diversity in the aggregation and evolution of proteins
    Caroline F Wright
    Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK
    Nature 438:878-81. 2005
    ..We propose that such low sequence identities could have a crucial and general role in safeguarding proteins against misfolding and aggregation...
  63. ncbi request reprint The properties of protein family space depend on experimental design
    Victor Kunin
    Computational Genomics Group, The European Bioinformatics Institute, EMBL Cambridge Outstation, Cambridge CB10 1SD, UK
    Bioinformatics 21:2618-22. 2005
    ..Databases of protein families often exhibit drastically different properties of the protein family space...
  64. ncbi request reprint Genomic analysis of regulatory network dynamics reveals large topological changes
    Nicholas M Luscombe
    Department of Molecular Biophysics and Biochemistry, Yale University, PO Box 208114, New Haven, Connecticut 06520 8114, USA
    Nature 431:308-12. 2004
    ..We anticipate that many of the concepts presented here--particularly the large-scale topological changes and hub transience--will apply to other biological networks, including complex sub-systems in higher eukaryotes...
  65. doi request reprint Sequences and topology: from genome structure to protein structure
    Sarah A Teichmann
    Curr Opin Struct Biol 18:340-1. 2008
  66. pmc Comparison of the small molecule metabolic enzymes of Escherichia coli and Saccharomyces cerevisiae
    Oliver Jardine
    Department of Crystallography, Birkbeck College, London WC1E 7HX, United Kingdom
    Genome Res 12:916-29. 2002
    ..Only one fifth of the common enzymes have nonhomologous domains between the two organisms. Around the common core very different extensions have been made to small molecule metabolism in the two organisms...
  67. pmc Integrated mapping, chromosomal sequencing and sequence analysis of Cryptosporidium parvum
    Alan T Bankier
    Medical Research Council MRC Laboratory of Molecular Biology, Cambridge CB 2 2QH, UK
    Genome Res 13:1787-99. 2003
    ..parvum, whereas the other is shared with (but has previously gone unnoticed in) all known genomes of the Coccidia and Haemosporida. These motifs appear to be unique in their structure, distribution and sequences...
  68. pmc Common variants near MC4R are associated with fat mass, weight and risk of obesity
    Ruth J F Loos
    MRC Epidemiology Unit, Addenbrooke s Hospital, Cambridge CB2 0QQ, UK
    Nat Genet 40:768-75. 2008
    ....