S S Taylor

Summary

Affiliation: University of Manchester
Country: UK

Publications

  1. ncbi request reprint Kinetochore localisation and phosphorylation of the mitotic checkpoint components Bub1 and BubR1 are differentially regulated by spindle events in human cells
    S S Taylor
    School of Biological Sciences, University of Manchester, 2 205 Stopford Building, Oxford Road, Manchester M13 9PT, UK
    J Cell Sci 114:4385-95. 2001
  2. pmc Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores
    Claire Ditchfield
    School of Biological Sciences, University of Manchester, 2 205 Stopford Building, Oxford Rd, Manchester M13 9PT, UK
    J Cell Biol 161:267-80. 2003
  3. ncbi request reprint Chromosome segregation: dual control ensures fidelity
    S S Taylor
    School of Biological Sciences, University of Manchester, 2 205 Stopford Building, Oxford Road, Manchester, M13 9PT, UK
    Curr Biol 9:R562-4. 1999
  4. ncbi request reprint The spindle checkpoint: a quality control mechanism which ensures accurate chromosome segregation
    Stephen S Taylor
    School of Biological Sciences, University of Manchester, The Michael Smith Building, Oxford Road, Manchester M13 9PT, United Kingdom
    Chromosome Res 12:599-616. 2004
  5. pmc Aneuploid colon cancer cells have a robust spindle checkpoint
    A Tighe
    School of Biological Sciences, University of Manchester, 2.205 Stopford Building, Manchester M13 9PT, UK
    EMBO Rep 2:609-14. 2001
  6. doi request reprint Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery
    Libor Macurek
    Department of Medical Oncology, University Medical Center Utrecht, Utrecht 3584CG, The Netherlands
    Nature 455:119-23. 2008
  7. ncbi request reprint Bub1 maintains centromeric cohesion by activation of the spindle checkpoint
    David Perera
    Faculty of Life Sciences, University of Manchester, Michael Smith Building, Oxford Road, Manchester M13 9PT, United Kingdom
    Dev Cell 13:566-79. 2007
  8. pmc GSK-3 inhibitors induce chromosome instability
    Anthony Tighe
    Faculty of Life Sciences, Michael Smith Building, Oxford Road, University of Manchester, Manchester M13 9PT, UK
    BMC Cell Biol 8:34. 2007
  9. ncbi request reprint Protein phosphatase 2A and separase form a complex regulated by separase autocleavage
    Andrew J Holland
    Faculty of Life Sciences, Michael Smith Building, Oxford Road, University of Manchester, Manchester M13 9PT, United Kingdom
    J Biol Chem 282:24623-32. 2007
  10. ncbi request reprint Cenp-F links kinetochores to Ndel1/Nde1/Lis1/dynein microtubule motor complexes
    Mailys A S Vergnolle
    Faculty of Life Sciences, Michael Smith Building, Oxford Road, University of Manchester, Manchester, UK
    Curr Biol 17:1173-9. 2007

Collaborators

Detail Information

Publications23

  1. ncbi request reprint Kinetochore localisation and phosphorylation of the mitotic checkpoint components Bub1 and BubR1 are differentially regulated by spindle events in human cells
    S S Taylor
    School of Biological Sciences, University of Manchester, 2 205 Stopford Building, Oxford Road, Manchester M13 9PT, UK
    J Cell Sci 114:4385-95. 2001
    ..We suggest therefore that Bub1 and BubR1 may integrate different 'spindle assembly signals' into a single signal which can then be interpreted by downstream cell cycle regulators...
  2. pmc Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores
    Claire Ditchfield
    School of Biological Sciences, University of Manchester, 2 205 Stopford Building, Oxford Rd, Manchester M13 9PT, UK
    J Cell Biol 161:267-80. 2003
    ..Together, these results suggest that by targeting checkpoint proteins to kinetochores, Aurora B couples chromosome alignment with anaphase onset...
  3. ncbi request reprint Chromosome segregation: dual control ensures fidelity
    S S Taylor
    School of Biological Sciences, University of Manchester, 2 205 Stopford Building, Oxford Road, Manchester, M13 9PT, UK
    Curr Biol 9:R562-4. 1999
    ..A mitotic checkpoint arrests cell cycle progression in response to spindle damage. It now appears that this checkpoint has two separate arms, one that prevents anaphase and a second that prevents cytokinesis and DNA re-replication...
  4. ncbi request reprint The spindle checkpoint: a quality control mechanism which ensures accurate chromosome segregation
    Stephen S Taylor
    School of Biological Sciences, University of Manchester, The Michael Smith Building, Oxford Road, Manchester M13 9PT, United Kingdom
    Chromosome Res 12:599-616. 2004
    ..This article provides a brief historical overview before focusing on some of the outstanding issues and more recent developments in the field...
  5. pmc Aneuploid colon cancer cells have a robust spindle checkpoint
    A Tighe
    School of Biological Sciences, University of Manchester, 2.205 Stopford Building, Manchester M13 9PT, UK
    EMBO Rep 2:609-14. 2001
    ..Significantly, we show here that expression of an APC mutant in MIN cells reduces the mitotic index following spindle damage to a level observed in CIN cells, suggesting that APC dysfunction may contribute to CIN...
  6. doi request reprint Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery
    Libor Macurek
    Department of Medical Oncology, University Medical Center Utrecht, Utrecht 3584CG, The Netherlands
    Nature 455:119-23. 2008
    ..Taken together, these data demonstrate that the initial activation of PLK1 is a primary function of aurora A...
  7. ncbi request reprint Bub1 maintains centromeric cohesion by activation of the spindle checkpoint
    David Perera
    Faculty of Life Sciences, University of Manchester, Michael Smith Building, Oxford Road, Manchester M13 9PT, United Kingdom
    Dev Cell 13:566-79. 2007
    ..Centromeres in Bub1-deficient cells also separate prematurely; however, we show that this is a consequence of SAC dysfunction rather than a direct role for Bub1 in protecting centromeric cohesion...
  8. pmc GSK-3 inhibitors induce chromosome instability
    Anthony Tighe
    Faculty of Life Sciences, Michael Smith Building, Oxford Road, University of Manchester, Manchester M13 9PT, UK
    BMC Cell Biol 8:34. 2007
    ..Here, we turn our attention to GSK-3 - a protein kinase, which in concert with APC, targets beta-catenin for proteolysis - and ask whether GSK-3 is required for accurate chromosome segregation...
  9. ncbi request reprint Protein phosphatase 2A and separase form a complex regulated by separase autocleavage
    Andrew J Holland
    Faculty of Life Sciences, Michael Smith Building, Oxford Road, University of Manchester, Manchester M13 9PT, United Kingdom
    J Biol Chem 282:24623-32. 2007
    ..Together these observations provide a new mechanistic insight into a physiological function for separase self-cleavage...
  10. ncbi request reprint Cenp-F links kinetochores to Ndel1/Nde1/Lis1/dynein microtubule motor complexes
    Mailys A S Vergnolle
    Faculty of Life Sciences, Michael Smith Building, Oxford Road, University of Manchester, Manchester, UK
    Curr Biol 17:1173-9. 2007
    ..A major function of Cenp-F, therefore, is to link the Ndel1/Nde1/Lis1/Dynein pathway to kinetochores. Furthermore, our data demonstrate that Ndel1 and Nde1 play distinct roles to ensure chromosome alignment and segregation...
  11. pmc Comment on "A centrosome-independent role for gamma-TuRC proteins in the spindle assembly checkpoint"
    Stephen S Taylor
    Faculty of Life Sciences, University of Manchester, Manchester, UK
    Science 316:982; author reply 982. 2007
    ..Because gamma-TuRC inhibition leads to pleiotropic spindle defects, which are well known to activate kinetochore-derived checkpoint signaling, we believe that this conclusion is premature...
  12. ncbi request reprint Validating Aurora B as an anti-cancer drug target
    Fiona Girdler
    Faculty of Life Sciences, Michael Smith Building, Oxford Road, University of Manchester, Manchester, M13 9PT, UK
    J Cell Sci 119:3664-75. 2006
    ..Because small molecule-mediated inhibition of Aurora A and Aurora B yields distinct phenotypes, our observations indicate that the Auroras may present two avenues for anti-cancer drug discovery...
  13. ncbi request reprint Cyclin-B1-mediated inhibition of excess separase is required for timely chromosome disjunction
    Andrew J Holland
    Faculty of Life Sciences, Michael Smith Building, Oxford Road, University of Manchester, Manchester, M13 9PT, UK
    J Cell Sci 119:3325-36. 2006
    ..Surprisingly, however, cohesion is maintained during the early stages of mitosis, indicating the existence of another mechanism that either inhibits separase or protects its substrate during early mitosis...
  14. ncbi request reprint Silencing Cenp-F weakens centromeric cohesion, prevents chromosome alignment and activates the spindle checkpoint
    Sarah V Holt
    Faculty of Life Sciences, University of Manchester, The Michael Smith Building, Oxford Road, Manchester, M13 9PT, UK
    J Cell Sci 118:4889-900. 2005
    ..Intriguingly, whereas most of the sister-less kinetochores cluster near the spindle poles, some align at the spindle equator, possibly through merotelic or lateral orientations...
  15. ncbi request reprint Farnesylation of Cenp-F is required for G2/M progression and degradation after mitosis
    Deema Hussein
    School of Biological Sciences, University of Manchester, 2 205 Stopford Building, Oxford Road, Manchester M13 9PT, UK
    J Cell Sci 115:3403-14. 2002
    ..In addition, these observations raise the possibility that the anti-proliferative effects induced by farnesyl transferase inhibitors may be due to inhibition of Cenp-F function and/or turnover...
  16. ncbi request reprint Bub1 is required for kinetochore localization of BubR1, Cenp-E, Cenp-F and Mad2, and chromosome congression
    Victoria L Johnson
    School of Biological Sciences, University of Manchester, 2 205 Stopford Building, Oxford Road, Manchester M13 9PT, UK
    J Cell Sci 117:1577-89. 2004
    ..This raises the possibility that, in the absence of Bub1, other mechanisms contribute to spindle checkpoint function...
  17. ncbi request reprint Truncating APC mutations have dominant effects on proliferation, spindle checkpoint control, survival and chromosome stability
    Anthony Tighe
    Faculty of Life Sciences, University of Manchester, The Michael Smith Building, Oxford Road, Manchester, M13 9PT, UK
    J Cell Sci 117:6339-53. 2004
    ..We suggest therefore that the initial APC mutation acts as a 'double whammy', destabilising the genome and setting the stage for deregulated proliferation upon loss of the second APC allele...
  18. pmc The kinase haspin is required for mitotic histone H3 Thr 3 phosphorylation and normal metaphase chromosome alignment
    Jun Dai
    Division of Rheumatology, Immunology and Allergy, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genes Dev 19:472-88. 2005
    ..This work reveals a new kinase involved in composing the histone code and adds haspin to the select group of kinases that integrate regulation of chromosome and spindle function during mitosis and meiosis...
  19. ncbi request reprint Bub1 and aurora B cooperate to maintain BubR1-mediated inhibition of APC/CCdc20
    Christopher J Morrow
    Faculty of Sciences, University of Manchester, The Michael Smith Building, Oxford Road, Manchester, M13 9PT, UK
    J Cell Sci 118:3639-52. 2005
    ..This bifurcation in the signalling mechanism may help explain why many tumour cells mount a robust checkpoint response following spindle damage, despite exhibiting chromosome instability...
  20. doi request reprint Cancer cells display profound intra- and interline variation following prolonged exposure to antimitotic drugs
    Karen E Gascoigne
    Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester M13 9PT, UK
    Cancer Cell 14:111-22. 2008
    ..We present data supporting a model wherein cell fate is dictated by two competing networks, one involving caspase activation, the other protecting cyclin B1 from degradation...
  21. ncbi request reprint The Ipl1/Aurora kinase family: methods of inhibition and functional analysis in mammalian cells
    Claire Ditchfield
    School of Biological Sciences, University of Manchester, Manchester, UK
    Methods Mol Biol 296:371-81. 2005
    ..Furthermore, because the mechanism underlying the inhibition is different in each case, caution must be taken when interpreting the data...
  22. ncbi request reprint Mitochondrial targeting of adenomatous polyposis coli protein is stimulated by truncating cancer mutations: regulation of Bcl-2 and implications for cell survival
    Mariana Brocardo
    Westmead Institute for Cancer Research, University of Sydney, Westmead Millennium Institute at Westmead Hospital, Westmead, New South Wales 2145, Australia
    J Biol Chem 283:5950-9. 2008
    ..We propose that a subset of cancer mutations induce APC mitochondrial localization and that APC regulation of Bcl-2 at mitochondria may contribute to tumor cell survival...
  23. ncbi request reprint Bub1 up-regulation and hyperphosphorylation promote malignant transformation in SV40 tag-induced transgenic mouse models
    Conghui Guo
    Department of Surgery, University of Western Ontario, London, Ontario, Canada
    Mol Cancer Res 4:957-69. 2006
    ....