Roy Taylor

Summary

Affiliation: University of Newcastle
Country: UK

Publications

  1. doi request reprint Combination peroxisome proliferator-activated receptor gamma and alpha agonist treatment in Type 2 diabetes prevents the beneficial pioglitazone effect on liver fat content
    R Balasubramanian
    Newcastle Magnetic Resonance Centre, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK
    Diabet Med 27:150-6. 2010
  2. pmc Banting Memorial lecture 2012: reversing the twin cycles of type 2 diabetes
    R Taylor
    Magnetic Resonance Centre, Institute of Cellular Medicine Newcastle University, Newcastle upon Tyne, UK
    Diabet Med 30:267-75. 2013
  3. pmc Reversal of type 2 diabetes: normalisation of beta cell function in association with decreased pancreas and liver triacylglycerol
    E L Lim
    Magnetic Resonance Centre, Institute of Cellular Medicine, Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne, NE4 5PL, UK
    Diabetologia 54:2506-14. 2011
  4. ncbi request reprint Digami too?
    R Taylor
    Medical School, University of Newcastle upon Tyne, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK
    Diabetologia 49:1134-7. 2006
  5. doi request reprint Pathogenesis of type 2 diabetes: tracing the reverse route from cure to cause
    R Taylor
    Magnetic Resonance Centre, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, UK
    Diabetologia 51:1781-9. 2008
  6. ncbi request reprint Appropriate insulin regimes for type 2 diabetes: a multicenter randomized crossover study
    R Taylor
    Diabetes Center, Newcastle upon Tyne, UK
    Diabetes Care 23:1612-8. 2000
  7. ncbi request reprint Clinical outcomes of pregnancy in women with type 1 diabetes(1)
    Roy Taylor
    Department of Medicine, Royal Victoria Infirmary, Newcastle upon Tyne, United Kingdom
    Obstet Gynecol 99:537-41. 2002
  8. pmc Type 1 diabetes and pregnancy
    Roy Taylor
    Newcastle University, and Royal Victoria Infirmary, Newcastle upon Tyne
    BMJ 334:742-5. 2007
  9. pmc Pioglitazone decreases fasting and postprandial endogenous glucose production in proportion to decrease in hepatic triglyceride content
    Balasubramanian Ravikumar
    Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, U K
    Diabetes 57:2288-95. 2008
  10. doi request reprint Loss of capacity to recover from acidosis in repeat exercise is strongly associated with fatigue in primary biliary cirrhosis
    Kieren G Hollingsworth
    Newcastle Magnetic Resonance Centre, Newcastle University, UK
    J Hepatol 53:155-61. 2010

Collaborators

Detail Information

Publications45

  1. doi request reprint Combination peroxisome proliferator-activated receptor gamma and alpha agonist treatment in Type 2 diabetes prevents the beneficial pioglitazone effect on liver fat content
    R Balasubramanian
    Newcastle Magnetic Resonance Centre, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK
    Diabet Med 27:150-6. 2010
    ..However, the precise effects of combined PPAR-gamma and PPAR-alpha therapy on intra-organ triglyceride content and insulin sensitivity in subjects with Type 2 diabetes have not yet been determined...
  2. pmc Banting Memorial lecture 2012: reversing the twin cycles of type 2 diabetes
    R Taylor
    Magnetic Resonance Centre, Institute of Cellular Medicine Newcastle University, Newcastle upon Tyne, UK
    Diabet Med 30:267-75. 2013
    ..It is now clear that Type 2 diabetes is a reversible condition of intra-organ fat excess to which some people are more susceptible than others...
  3. pmc Reversal of type 2 diabetes: normalisation of beta cell function in association with decreased pancreas and liver triacylglycerol
    E L Lim
    Magnetic Resonance Centre, Institute of Cellular Medicine, Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne, NE4 5PL, UK
    Diabetologia 54:2506-14. 2011
    ..Type 2 diabetes is regarded as inevitably progressive, with irreversible beta cell failure. The hypothesis was tested that both beta cell failure and insulin resistance can be reversed by dietary restriction of energy intake...
  4. ncbi request reprint Digami too?
    R Taylor
    Medical School, University of Newcastle upon Tyne, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK
    Diabetologia 49:1134-7. 2006
  5. doi request reprint Pathogenesis of type 2 diabetes: tracing the reverse route from cure to cause
    R Taylor
    Magnetic Resonance Centre, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, UK
    Diabetologia 51:1781-9. 2008
    ..These defects are capable of dramatic reversal under hypoenergetic feeding conditions, completely in early diabetes and to a worthwhile extent in more established disease...
  6. ncbi request reprint Appropriate insulin regimes for type 2 diabetes: a multicenter randomized crossover study
    R Taylor
    Diabetes Center, Newcastle upon Tyne, UK
    Diabetes Care 23:1612-8. 2000
    ..Patient treatment satisfaction and quality of life were also examined before and during each treatment...
  7. ncbi request reprint Clinical outcomes of pregnancy in women with type 1 diabetes(1)
    Roy Taylor
    Department of Medicine, Royal Victoria Infirmary, Newcastle upon Tyne, United Kingdom
    Obstet Gynecol 99:537-41. 2002
    ..To evaluate predictors of neonatal hypoglycemia and macrosomia in 107 consecutive pregnancies in type 1 diabetic women...
  8. pmc Type 1 diabetes and pregnancy
    Roy Taylor
    Newcastle University, and Royal Victoria Infirmary, Newcastle upon Tyne
    BMJ 334:742-5. 2007
  9. pmc Pioglitazone decreases fasting and postprandial endogenous glucose production in proportion to decrease in hepatic triglyceride content
    Balasubramanian Ravikumar
    Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, U K
    Diabetes 57:2288-95. 2008
    ..We studied the effect of pioglitazone on hepatic triglyceride content and the consequent effect on postprandial endogenous glucose production (EGP) in type 2 diabetes...
  10. doi request reprint Loss of capacity to recover from acidosis in repeat exercise is strongly associated with fatigue in primary biliary cirrhosis
    Kieren G Hollingsworth
    Newcastle Magnetic Resonance Centre, Newcastle University, UK
    J Hepatol 53:155-61. 2010
    ..We modelled this effect by exploring kinetics of pH recovery during 3 linked exercise episodes using magnetic resonance spectroscopy (MRS)...
  11. pmc Inhibition of lipolysis in Type 2 diabetes normalizes glucose disposal without change in muscle glycogen synthesis rates
    Ee L Lim
    Newcastle Magnetic Resonance Centre, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne NE4 5PL, UK
    Clin Sci (Lond) 121:169-77. 2011
    ..ATP turnover rate in muscle exhibits no relationship to the acute metabolic effect of insulin...
  12. pmc Effects of raising muscle glycogen synthesis rate on skeletal muscle ATP turnover rate in type 2 diabetes
    Ee L Lim
    Institute of Cellular Medicine, Newcastle Magnetic Resonance Centre, Newcastle University, Newcastle upon Tyne, United Kingdom
    Am J Physiol Endocrinol Metab 301:E1155-62. 2011
    ..In type 2 diabetes, skeletal muscle ATP turnover rates reflect the rate of glucose uptake and glycogen synthesis, rather than any primary mitochondrial defect...
  13. ncbi request reprint Acute inhibition of lipolysis does not affect postprandial suppression of endogenous glucose production
    Peter E Carey
    Dept of Medicine, The Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH, UK
    Am J Physiol Endocrinol Metab 289:E941-7. 2005
    ..Acute pharmacological sequestration of fatty acids in triglyceride stores improves postprandial glucose homeostasis without effect on the immediate postprandial suppression of EGP...
  14. doi request reprint Impaired cerebral autoregulation in primary biliary cirrhosis: implications for the pathogenesis of cognitive decline
    Kieren G Hollingsworth
    Newcastle Magnetic Resonance Centre, Newcastle University, Newcastle upon Tyne, UK
    Liver Int 30:878-85. 2010
    ..Cognitive impairment is recognised in the early stages of primary biliary cirrhosis (PBC)...
  15. ncbi request reprint Effect of repaglinide and gliclazide on postprandial control of endogenous glucose production
    Parag Singhal
    Diabetes Research Group, The Medical School, School of Clinical Medical Sciences, University of Newcastle upon Tyne, New Castle upon Tyne NE2, 4HH, UK
    Metabolism 54:79-84. 2005
    ..17). Repaglinide has minimal physiological advantage over gliclazide, but both therapies for type 2 diabetes fall far short of correcting the endocrine and metabolic abnormalities...
  16. doi request reprint Cardiac structure and function are altered in adults with non-alcoholic fatty liver disease
    Kate Hallsworth
    Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK
    J Hepatol 58:757-62. 2013
    ..This study aimed to address this by defining the effect of NAFLD on cardiac function, structure, and metabolism...
  17. doi request reprint Impaired cardiovascular response to standing in chronic fatigue syndrome
    Kieren G Hollingsworth
    Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK
    Eur J Clin Invest 40:608-15. 2010
    ..This study examined the relationship between skeletal and cardiac muscle function and symptoms on standing in CFS using magnetic resonance spectroscopy (MRS) and impedance cardiography...
  18. pmc The second-meal phenomenon in type 2 diabetes
    Ana Jovanovic
    Diabetes Research Group and Newcastle Magnetic Resonance Centre, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK
    Diabetes Care 32:1199-201. 2009
    ..In health, the rise in glucose after lunch is less if breakfast is eaten. We evaluated the second-meal effect in type 2 diabetes...
  19. pmc Measuring the acute effect of insulin infusion on ATP turnover rate in human skeletal muscle using phosphorus-31 magnetic resonance saturation transfer spectroscopy
    Ee Lin Lim
    Institute of Cellular Medicine, Newcastle Magnetic Resonance Centre, Newcastle University, Newcastle upon Tyne, UK
    NMR Biomed 23:952-7. 2010
    ..03 vs baseline). The in vivo time course of insulin stimulation of skeletal muscle ATP turnover rate is not consistent with a rate limiting effect upon the initiation of insulin-stimulated glycogen synthesis...
  20. pmc Cardiac torsion-strain relationships in fatigued primary biliary cirrhosis patients show accelerated aging: a pilot cross-sectional study
    Kieren G Hollingsworth
    Newcastle Magnetic Resonance Centre and Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom
    J Appl Physiol (1985) 112:2043-8. 2012
    ..This is analogous to the changes found in healthy aging for subjects ∼16 yr older than the fatigued PBC patients. Hence the hearts of fatigued PBC patients may be subject to processes of accelerated aging...
  21. doi request reprint The second-meal phenomenon is associated with enhanced muscle glycogen storage in humans
    Ana Jovanovic
    Diabetes Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, U K
    Clin Sci (Lond) 117:119-27. 2009
    ..48, P<0.05). The second-meal effect is associated with priming of muscle glycogen synthesis consequent upon sustained suppression of plasma NEFA concentrations...
  22. doi request reprint Globus pallidus magnetization transfer ratio, T(1) and T(2) in primary biliary cirrhosis: relationship with disease stage and age
    Kieren G Hollingsworth
    Newcastle Magnetic Resonance Centre, Newcastle University, UK
    J Magn Reson Imaging 29:780-4. 2009
    ....
  23. pmc Resistance exercise reduces liver fat and its mediators in non-alcoholic fatty liver disease independent of weight loss
    Kate Hallsworth
    Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK2NIHR Biomedical Research Centre for Ageing and Age related Disease, Newcastle University, Newcastle upon Tyne, UK
    Gut 60:1278-83. 2011
    ..Aerobic exercise is not well sustained and the effectiveness of the better tolerated resistance exercise upon liver lipid and mediators of liver lipid has not been assessed...
  24. pmc Increased daily walking improves lipid oxidation without changes in mitochondrial function in type 2 diabetes
    Michael I Trenell
    Diabetes Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK
    Diabetes Care 31:1644-9. 2008
    ..To determine whether increased daily physical activity improves mitochondrial function and/or lipid oxidation in type 2 diabetes...
  25. pmc Utilizing the second-meal effect in type 2 diabetes: practical use of a soya-yogurt snack
    Mei Jun Chen
    Newcastle Magnetic Resonance Centre, Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne, UK
    Diabetes Care 33:2552-4. 2010
    ..To evaluate the effect of a prebreakfast high-protein snack upon postbreakfast hyperglycemia...
  26. doi request reprint Pilot study of peripheral muscle function in primary biliary cirrhosis: potential implications for fatigue pathogenesis
    Kieren G Hollingsworth
    Newcastle Magnetic Resonance Centre, Newcastle University, Newcastle upon Tyne, United Kingdom
    Clin Gastroenterol Hepatol 6:1041-8. 2008
    ..Although anti-PDC inhibits PDC function in vitro, mitochondrial function in vivo in PBC has not been examined...
  27. pmc Hepatic cholesteryl ester accumulation in lysosomal acid lipase deficiency: non-invasive identification and treatment monitoring by magnetic resonance
    Peter E Thelwall
    Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK
    J Hepatol 59:543-9. 2013
    ..Secondly, we used MR spectroscopy to monitor the effects of an enzyme replacement therapy (ERT), sebelipase alfa (a recombinant human lysosomal acid lipase), on hepatic TG and CE content in the preclinical model...
  28. pmc Impaired cardiovascular function in primary biliary cirrhosis
    David E J Jones
    Institute of Cellular Medicine, Newcastle Univ, UK
    Am J Physiol Gastrointest Liver Physiol 298:G764-73. 2010
    ..005). Our findings suggest the presence of altered myocardial function in PBC. Autonomic "dysfunction" may, rather than being an abnormal process, represent a compensatory mechanism to increase cardiac return to mitigate these effects...
  29. ncbi request reprint Effect of insulin therapy on plasma leptin and body weight in patients with type 2 diabetes
    P E Carey
    Diabetes Centre, Newcastle upon Tyne
    Horm Metab Res 35:372-6. 2003
    ..This study set out to define relationships between changes in plasma leptin and changes in body weight, plasma insulin and blood glucose control during a 12-month crossover study of once-daily Ultratard or twice-daily Insulatard insulin...
  30. ncbi request reprint Life-threatening hypokalaemia on a low-carbohydrate diet associated with previously undiagnosed primary hyperaldosteronism [corrected]
    A Advani
    Department of Diabetes and Metabolism, Medical School, William Leech Building, 1 Framlington Place, Newcastle upon Tyne NE2 4HH, UK
    Diabet Med 22:1605-7. 2005
    ..We present a patient with Type 2 diabetes and previously undiagnosed hyperaldosteronism who developed life-threatening hypokalaemia while following a low-carbohydrate diet...
  31. ncbi request reprint Causation of type 2 diabetes -- the Gordian knot unravels
    Roy Taylor
    University of Newcastle upon Tyne Medical School, Newcastle upon Tyne, United Kingdom
    N Engl J Med 350:639-41. 2004
  32. pmc Do obese but metabolically normal women differ in intra-abdominal fat and physical activity levels from those with the expected metabolic abnormalities? A cross-sectional study
    Louise Hayes
    Institute of Health and Society, Newcastle University, Newcastle upon Tyne, UK
    BMC Public Health 10:723. 2010
    ..The aim of this study was to determine to what extent differences in metabolic health in very obese women are explained by differences in body fat distribution, insulin resistance and level of physical activity...
  33. ncbi request reprint Direct assessment of muscle glycogen storage after mixed meals in normal and type 2 diabetic subjects
    P E Carey
    Department of Diabetes and Metabolism, University of Newcastle upon Tyne, Newcastle upon Tyne NE2 4HH, United Kingdom
    Am J Physiol Endocrinol Metab 284:E688-94. 2003
    ..87, P < 0.002). This study quantitates for the first time the subnormal basal muscle glycogen concentration and the inadequate glycogen storage after meals in type 2 diabetes...
  34. ncbi request reprint Long-term progression of retinopathy after initiation of insulin therapy in Type 2 diabetes: an observational study
    C S Arun
    Department of Medicine, The Medical School, University of Newcastle, Newcastle upon Tyne, UK
    Diabetologia 47:1380-4. 2004
    ..Universal worsening of retinopathy after starting insulin therapy in Type 2 diabetes has been suggested in previous work...
  35. doi request reprint Cognitive impairment in primary biliary cirrhosis: symptom impact and potential etiology
    Julia L Newton
    Liver Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK
    Hepatology 48:541-9. 2008
    ..Structural brain lesions were found in PBC, the density of which correlated with degree of cognitive impairment (P = 0.01, r(2) = 0.5) and autonomic function (P = 0.03, r(2) = 0.2)...
  36. ncbi request reprint Regulation of endogenous glucose production after a mixed meal in type 2 diabetes
    Parag Singhal
    Diabetes Research Group, School of Clinical Medical Sciences, University of Newcastle upon Tyne, Newcastle upon Tyne NE2 4HH, United Kingdom
    Am J Physiol Endocrinol Metab 283:E275-83. 2002
    ..1.31 +/- 0.13 mg x kg(-1) x min(-1), P < 0.02). These data quantitate the initial rapid suppression of EGP after a mixed meal in type 2 diabetes and the contribution of continuing excess glucose production to subsequent hyperglycemia...
  37. ncbi request reprint Receptor binding and biological potency of despentapeptide insulin
    R Taylor
    Department of Medicine, University of Newcastle upon Tyne, United Kingdom
    Horm Metab Res 21:249-52. 1989
    ..These data suggest differences in the binding-action linking in the cells of different tissues and different species...
  38. ncbi request reprint Whole body protein kinetics in women: effect of pregnancy and IDDM during anabolic stimulation
    P G Whittaker
    Department of Obstetrics and Gynecology, University of Newcastle upon Tyne, Royal Victoria Infirmary, Newcastle, Tyne and Wear NE1 4LP, United Kingdom
    Am J Physiol Endocrinol Metab 279:E978-88. 2000
    ..05). These alterations may enable amino acid conservation for protein synthesis and accretion in late pregnancy. Well-controlled type 1 diabetes caused no abnormalities in the regulation of basal or stimulated protein metabolism...
  39. ncbi request reprint Management of incidental hyperglycaemia in acute medical emergencies
    A Al-Bermani
    Diabetes Unit, Royal Victoria Infirmary, Newcastle upon Tyne, UK
    Diabet Med 22:937-41. 2005
    ..To assess whether compliance with management guidelines for hyperglycaemia in acute medical emergencies was affected by prior diagnosis of diabetes, and to assess the effect of an educational campaign upon management...
  40. doi request reprint Influence of pregnancy on long-term progression of retinopathy in patients with type 1 diabetes
    C S Arun
    Royal Victoria Infirmary and Diabetes Centre, Newcastle upon Tyne, UK
    Diabetologia 51:1041-5. 2008
    ..It has been reported that deterioration continues in the months after delivery, but direct data are lacking. It is also unclear what impact pregnancy has on the long-term progression of retinopathy...
  41. ncbi request reprint Management of hyperemesis gravidarum: the importance of weight loss as a criterion for steroid therapy
    P Moran
    Department of Fetal Medicine, Royal Victoria Infirmary, Newcastle upon Tyne, UK
    QJM 95:153-8. 2002
    ....
  42. doi request reprint Abnormalities in pH handling by peripheral muscle and potential regulation by the autonomic nervous system in chronic fatigue syndrome
    D E J Jones
    Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK
    J Intern Med 267:394-401. 2010
    ..To examine muscle acid handling following exercise in chronic fatigue syndrome (CFS/ME) and the relationship with autonomic dysfunction...
  43. pmc The prevention of progression of arterial disease and diabetes (POPADAD) trial: factorial randomised placebo controlled trial of aspirin and antioxidants in patients with diabetes and asymptomatic peripheral arterial disease
    Jill Belch
    Institute of Cardiovascular Research, University of Dundee, Ninewells Hospital, Dundee DD1 9SY
    BMJ 337:a1840. 2008
    ..To determine whether aspirin and antioxidant therapy, combined or alone, are more effective than placebo in reducing the development of cardiovascular events in patients with diabetes mellitus and asymptomatic peripheral arterial disease...
  44. pmc A prevalent variant in PPP1R3A impairs glycogen synthesis and reduces muscle glycogen content in humans and mice
    David B Savage
    Department of Clinical Biochemistry and Medicine, University of Cambridge, Cambridge, United Kingdom
    PLoS Med 5:e27. 2008
    ..However, the functional implications of the mutation were not known. The objective of this study was to characterise the molecular and physiological consequences of this genetic variant...
  45. ncbi request reprint Mathematical model for photocatalytic destruction of organic contaminants in air
    Wipada Sanongraj
    Chemical Engineering Department, Ubon Ratchathani University, Ubon Ratchathani, Thailand
    J Air Waste Manag Assoc 57:1112-22. 2007
    ..We discuss applicability of the model to estimate the influence of process variables and to evaluate photocatalyst performance...