Research Topics
Genomes and Genes | Philip R TaylorSummaryAffiliation: University of Oxford Country: UK Publications
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Publications
Pattern recognition receptors and differentiation antigens define murine myeloid cell heterogeneity ex vivoPhilip R Taylor
Sir William Dunn School of Pathology, Oxford University, Oxford, GB
Eur J Immunol 33:2090-7. 2003....- The role of SIGNR1 and the beta-glucan receptor (dectin-1) in the nonopsonic recognition of yeast by specific macrophagesPhilip R Taylor
Sir William Dunn School of Pathology, Oxford University, South Parks Road, Oxford OX1 3RE, United Kingdom
J Immunol 172:1157-62. 2004..These studies have identified SIGNR1 as a major MR for fungal and other pathogens present on specific subsets of Mphi... - The beta-glucan receptor, dectin-1, is predominantly expressed on the surface of cells of the monocyte/macrophage and neutrophil lineagesPhilip R Taylor
Sir William Dunn School of Pathology, Oxford University, Oxford, United Kingdom
J Immunol 169:3876-82. 2002..These observations imply the existence of an additional mannan-dependent receptor involved in the recognition of zymosan by resident peritoneal Mphi... - Analysis of mannose receptor regulation by IL-4, IL-10, and proteolytic processing using novel monoclonal antibodiesLuisa Martinez-Pomares
Sir William Dunn School of Pathology, Oxford, United Kingdom
J Leukoc Biol 73:604-13. 2003..These data support a role for the MR in T helper cell type 2 cytokine-driven, immune responses and suggest a non-M(phi) contribution to sMR production in vivo... - Dectin-1 expression and function are enhanced on alternatively activated and GM-CSF-treated macrophages and are negatively regulated by IL-10, dexamethasone, and lipopolysaccharideJanet A Willment
Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom
J Immunol 171:4569-73. 2003..These results correlate with the known effects of these cytokines and other agents on the ability of the immune system to recognize and respond to fungal pathogens... - Mannose receptor expression and function define a new population of murine dendritic cellsEmma J McKenzie
Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom
J Immunol 178:4975-83. 2007..In accordance with these observations, ligands highly specific for the MR elicit enhanced humoral responses in vivo only when administered in combination with endotoxin... - Expression of functionally different dectin-1 isoforms by murine macrophagesSigrid E M Heinsbroek
Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom
J Immunol 176:5513-8. 2006..These results are the first evidence that dectin-1 isoforms are functionally distinct and indicate that differential isoform usage may represent a mechanism of regulating cellular responses to beta-glucans... 
Stage-specific sampling by pattern recognition receptors during Candida albicans phagocytosisSigrid E M Heinsbroek
Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom
PLoS Pathog 4:e1000218. 2008..albicans uptake. Our data suggest that pattern recognition receptors sample the fungal phagosome in a sequential fashion...- Dectin-2 is predominantly myeloid restricted and exhibits unique activation-dependent expression on maturing inflammatory monocytes elicited in vivoPhilip R Taylor
Sir William Dunn School of Pathology, Oxford University, Oxford, UK
Eur J Immunol 35:2163-74. 2005..These observations show Dectin-2 expression to be characteristic of monocyte activation/maturation at an inflammatory lesion and provide a new perspective on the interpretation of Dectin-2 function in vivo... - Dectin-1 is a major beta-glucan receptor on macrophagesGordon D Brown
Sir William Dunn School of Pathology, University of Oxford, United Kingdom
J Exp Med 196:407-12. 2002..Furthermore, these results identify Dectin-1 as a new target for examining the immunomodulatory properties of beta-glucans for therapeutic drug design... - Development of a specific system for targeting protein to metallophilic macrophagesPhilip R Taylor
Sir William Dunn School of Pathology, Oxford University, South Parks Road, Oxford OX1 3RE, United Kingdom
Proc Natl Acad Sci U S A 101:1963-8. 2004..This model will allow the dissection of the role of metallophilic M in an immune response in vivo... - The mannose receptor: linking homeostasis and immunity through sugar recognitionPhilip R Taylor
Sir William Dunn School of Pathology, Oxford University, South Parks Road, Oxford OX1 3RE, UK
Trends Immunol 26:104-10. 2005 - The carbohydrate-recognition domain of Dectin-2 is a C-type lectin with specificity for high mannoseEamon P McGreal
Sir William Dunn School of Pathology, Oxford University, Oxford OX1 3RE, UK
Glycobiology 16:422-30. 2006.... - Actin and phosphoinositide recruitment to fully formed Candida albicans phagosomes in mouse macrophagesSigrid E M Heinsbroek
Sir William Dunn School of Pathology, University of Oxford, Oxford, UK
J Innate Immun 1:244-53. 2009..albicans phagosome was independent of PI3K. The ability of mature C. albicans phagosomes to stimulate actin polymerization could facilitate the escape of the growing yeast from the Mphi... - Innate immune response to human bone marrow fibroblastic cell implantation in CB17 scid/beige miceZhidao Xia
Botnar Research Centre, Institute of Musculoskeletal Science, Nuffield Department of Orthopaedic Surgery, The University of Oxford, Oxford, OX3 7LD, United Kingdom
J Cell Biochem 98:966-80. 2006..This study highlights the importance of the innate immune cells in the anti-xenograft response and suggests that strategies to block the activities of these cells may ameliorate the progressive long-term elimination of xenotransplants... - Monocyte and macrophage heterogeneitySiamon Gordon
Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
Nat Rev Immunol 5:953-64. 2005..These advances in our understanding have implications for the development of therapeutic strategies that are targeted to modify particular subpopulations of monocytes... - RNA interference mutant induction in vivo demonstrates the essential nature of trypanosome flagellar function during mammalian infectionSamantha Griffiths
Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, United Kingdom
Eukaryot Cell 6:1248-50. 2007..This validation provides a paradigm for the flagellum as a target for future assays and interventions against this human pathogen... - The follicular dendritic cell restricted epitope, FDC-M2, is complement C4; localization of immune complexes in mouse tissuesPhilip R Taylor
Sir William Dunn School of Pathology, Oxford University, South Parks Road, Oxford, GB
Eur J Immunol 32:1888-96. 2002..These results demonstrate that mAb209, in addition to its role as an FDC marker, is a valuable reagent for the analysis of complement deposition in vivo... - Monocyte heterogeneity and innate immunityPhilip R Taylor
Sir William Dunn School of Pathology, Oxford University, South Parks Road, OX1 3RE, Oxford, United Kingdom
Immunity 19:2-4. 2003..In this issue, Geissmann et al. use chemokine receptors to define two monocyte subsets and Serbina et al. highlight the importance of selective monocyte recruitment in the innate immune response to Listeria... - Regulation of cytosolic phospholipase A2 activation and cyclooxygenase 2 expression in macrophages by the beta-glucan receptorSaritha Suram
Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
J Biol Chem 281:5506-14. 2006.... - Recognition of bacterial capsular polysaccharides and lipopolysaccharides by the macrophage mannose receptorSusanne Zamze
Edward Jenner Institute for Vaccine Research, Compton, Berkshire RG20 7NN, United Kingdom
J Biol Chem 277:41613-23. 2002..The possible involvement of the mannose receptor, either cell surface or soluble, in the innate and adaptive immune responses to bacterial polysaccharides is discussed... - The induction of inflammation by dectin-1 in vivo is dependent on myeloid cell programming and the progression of phagocytosisMarcela Rosas
Medical Biochemistry and Immunology, Cardiff University School of Medicine, Cardiff, United Kingdom
J Immunol 181:3549-57. 2008..This has implications for the mechanism by which myeloid cells are activated during fungal infections and the processes involved in the therapeutic manipulation of the immune system via exogenous dectin-1 stimulation or blockade... - Oncostatin M receptor-beta signaling limits monocytic cell recruitment in acute inflammationEmily Hams
Department of Medical Biochemistry and Immunology, Cardiff University, Cardiff, United Kingdom
J Immunol 181:2174-80. 2008..These findings suggest that IL-6 and OSM individually affect the profile of leukocyte trafficking, and they point to a hitherto unidentified interplay between OSM signaling and the inflammatory activation of NF-kappaB... - Syk kinase is required for collaborative cytokine production induced through Dectin-1 and Toll-like receptorsKevin M Dennehy
Institute of Infectious Disease and Molecular Medicine, Clinical Laboratory Sciences Division of Immunology, University of Cape Town, Cape Town, South Africa
Eur J Immunol 38:500-6. 2008..These findings establish the first example of Syk- and MyD88-coupled PRR collaboration, further supporting the concept that paired receptors collaborate to control infectious agents... - Murine CD93 (C1qRp) contributes to the removal of apoptotic cells in vivo but is not required for C1q-mediated enhancement of phagocytosisPeter J Norsworthy
Rheumatology Section, Division of Medicine, Faculty of Medicine, Imperial College, Hammersmith Campus, London, UK
J Immunol 172:3406-14. 2004..However, our results suggest that it may contribute to the in vivo clearance of dying cells... - Dectin-1 is required for beta-glucan recognition and control of fungal infectionPhilip R Taylor
Sir William Dunn School of Pathology, University of Oxford, Oxford OX13RE, UK
Nat Immunol 8:31-8. 2007..Our results establish a fundamental function for beta-glucan recognition by dectin-1 in antifungal immunity and demonstrate a signaling non-Toll-like pattern-recognition receptor required for the induction of protective immune responses... - Ly49B is expressed on multiple subpopulations of myeloid cellsFrances Gays
Institute of Cell and Molecular Biosciences, The Medical School, Newcastle NE2 4HH, United Kingdom
J Immunol 177:5840-51. 2006..In transfected cells, Ly49B was found to associate with SHP-1, SHP-2, and SHIP in a manner strongly regulated by intracellular phosphorylation events... - Soluble Dectin-1 as a tool to detect beta-glucansLisa M Graham
Institute of Infectious Disease and Molecular Medicine, CLS, Faculty of Health Sciences, University of Cape Town, Observatory, 7925 Cape Town, South Africa
J Immunol Methods 314:164-9. 2006.... - Expression of the beta-glucan receptor, Dectin-1, on murine leukocytes in situ correlates with its function in pathogen recognition and reveals potential roles in leukocyte interactionsDelyth M Reid
The Edward Jenner Institute for Vaccine Research, Compton, Berkshire, RG20 7NN, UK
J Leukoc Biol 76:86-94. 2004..Tissue localization thus revealed potential roles of Dectin-1 in leukocyte interactions during innate immune responses and T cell development... - Polymorphisms in inflammation-related genes and risk of gastric cancer (Finland)Farin Kamangar
Division of Cancer Epidemiology and Genetics, US National Cancer Institute, Bethesda, MD 20892 7232, USA
Cancer Causes Control 17:117-25. 2006..Our results do not support the hypothesis that polymorphisms in genes involved in the inflammatory response confer differences in gastric cancer risk among different individuals... - Variants of the IL8 and IL8RB genes and risk for gastric cardia adenocarcinoma and esophageal squamous cell carcinomaSharon A Savage
Section on Genomic Variation, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, Advanced Technology Center, 8717 Grovemont Circle, Gaithersburg, MD 20892 4605, USA
Cancer Epidemiol Biomarkers Prev 13:2251-7. 2004..These variants could confer an altered IL8 expression pattern or interact with environmental factors to increase the risk for inflammation and GCC... - Polymorphisms in interleukin -2, -6, and -10 are not associated with gastric cardia or esophageal cancer in a high-risk chinese populationSharon A Savage
Pediatric Oncology Branch, Center for Cancer Research, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA
Cancer Epidemiol Biomarkers Prev 13:1547-9. 2004 - Characterisation of murine MICL (CLEC12A) and evidence for an endogenous ligandElwira Pyz
The Institute of Infectious Disease and Molecular Medicine, Division of Immunology, University of Cape Town, Cape Town, South Africa
Eur J Immunol 38:1157-63. 2008..Finally, we show that mMICL recognises an endogenous ligand in a variety of murine tissues, suggesting that the receptor plays a role in homeostasis... - p16, MGMT, RARbeta2, CLDN3, CRBP and MT1G gene methylation in esophageal squamous cell carcinoma and its precursor lesionsMark J Roth
National Cancer Institute, 6120 Executive Blvd, EPS 320, MSC 7232, Rockville, MD 20892, USA
Oncol Rep 15:1591-7. 2006..Balloon cytology may be able to screen the length of the esophagus effectively for a subset of cells with abnormal methylation, and may be useful in a primary screening test for ESCC and its precursor lesions... - Characterisation of the expression and function of the GM-CSF receptor alpha-chain in miceMarcela Rosas
Medical Biochemistry and Immunology, Cardiff University School of Medicine, Cardiff, UK
Eur J Immunol 37:2518-28. 2007..The ability to detect GM-CSF receptor expression in experimental studies should greatly facilitate the analysis of its role in immune pathologies... - Common leptin receptor polymorphisms do not modify the effect of alcohol ingestion on serum leptin levels in a controlled feeding and alcohol ingestion studyMark J Roth
Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Suite 705, MSC 8314, Bethesda, Maryland 20892, USA
Cancer Epidemiol Biomarkers Prev 14:1576-8. 2005..No significant effects were found between common leptin receptor polymorphisms and serum leptin levels (P > or = 0.26)...