Matthew D Taylor

Summary

Affiliation: University of Edinburgh
Country: UK

Publications

  1. doi request reprint T cells in helminth infection: the regulators and the regulated
    Matthew D Taylor
    Institute of Immunology and Infection Research, University of Edinburgh, Ashworth Laboratories, Edinburgh, UK
    Trends Immunol 33:181-9. 2012
  2. pmc Cytokine responses to Schistosoma haematobium in a Zimbabwean population: contrasting profiles for IFN-gamma, IL-4, IL-5 and IL-10 with age
    Francisca Mutapi
    Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Ashworth Laboratories, King s Buildings, West Mains Rd, Edinburgh, EH9 3JT, UK
    BMC Infect Dis 7:139. 2007
  3. ncbi request reprint Human Trichuris-specific antibody responses in vaccinated hu-PBL-SCID mice
    Matthew D Taylor
    Institute of Cell, Animal and Population Biology, University of Edinburgh, Edinburgh and School of Biological Sciences, University of Manchester, Manchester, UK
    Parasite Immunol 24:1-13. 2002
  4. doi request reprint Early recruitment of natural CD4+ Foxp3+ Treg cells by infective larvae determines the outcome of filarial infection
    Matthew D Taylor
    Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh, UK
    Eur J Immunol 39:192-206. 2009
  5. ncbi request reprint CTLA-4 and CD4+ CD25+ regulatory T cells inhibit protective immunity to filarial parasites in vivo
    Matthew D Taylor
    Institute of Immunology and Infection Research, University of Edinburgh, United Kingdom
    J Immunol 179:4626-34. 2007
  6. ncbi request reprint Expansion of Foxp3+ regulatory T cells in mice infected with the filarial parasite Brugia malayi
    Henry J McSorley
    Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh, United Kingdom
    J Immunol 181:6456-66. 2008
  7. ncbi request reprint F4/80+ alternatively activated macrophages control CD4+ T cell hyporesponsiveness at sites peripheral to filarial infection
    Matthew D Taylor
    Institute of Immunology and Infection Research, Ashworth Laboratories, University of Edinburgh, Edinburgh, United Kingdom
    J Immunol 176:6918-27. 2006
  8. ncbi request reprint Removal of regulatory T cell activity reverses hyporesponsiveness and leads to filarial parasite clearance in vivo
    Matthew D Taylor
    Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh, United Kingdom
    J Immunol 174:4924-33. 2005
  9. pmc Helminth-induced CD19+CD23hi B cells modulate experimental allergic and autoimmune inflammation
    Mark S Wilson
    Centre for Immunity, Infection and Evolution, and Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh, UK
    Eur J Immunol 40:1682-96. 2010
  10. pmc Expansion and activation of CD4(+)CD25(+) regulatory T cells in Heligmosomoides polygyrus infection
    Constance A M Finney
    Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh, UK
    Eur J Immunol 37:1874-86. 2007

Collaborators

Detail Information

Publications18

  1. doi request reprint T cells in helminth infection: the regulators and the regulated
    Matthew D Taylor
    Institute of Immunology and Infection Research, University of Edinburgh, Ashworth Laboratories, Edinburgh, UK
    Trends Immunol 33:181-9. 2012
    ..Future vaccine or therapeutic strategies should aim to minimize extrinsic regulatory effects and simultaneously negate Th2 anergy to drive effector responses into a long-term functionally competent state...
  2. pmc Cytokine responses to Schistosoma haematobium in a Zimbabwean population: contrasting profiles for IFN-gamma, IL-4, IL-5 and IL-10 with age
    Francisca Mutapi
    Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Ashworth Laboratories, King s Buildings, West Mains Rd, Edinburgh, EH9 3JT, UK
    BMC Infect Dis 7:139. 2007
    ..This study determined the cytokine-age profiles of Zimbabweans resident in a Schistosoma haematobium endemic area and further investigated the relationship between the cytokine responses and infection intensity...
  3. ncbi request reprint Human Trichuris-specific antibody responses in vaccinated hu-PBL-SCID mice
    Matthew D Taylor
    Institute of Cell, Animal and Population Biology, University of Edinburgh, Edinburgh and School of Biological Sciences, University of Manchester, Manchester, UK
    Parasite Immunol 24:1-13. 2002
    ..muris homogenate in a donor-dependent manner. This work shows the potential of using the humanized mouse model for studying the immune responses of humans living in T. trichiura endemic areas...
  4. doi request reprint Early recruitment of natural CD4+ Foxp3+ Treg cells by infective larvae determines the outcome of filarial infection
    Matthew D Taylor
    Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh, UK
    Eur J Immunol 39:192-206. 2009
    ..These CD4(+)Foxp3(+) Treg cells are predominantly recruited from the 'natural' regulatory pool and act to inhibit protective immunity over the full course of infection...
  5. ncbi request reprint CTLA-4 and CD4+ CD25+ regulatory T cells inhibit protective immunity to filarial parasites in vivo
    Matthew D Taylor
    Institute of Immunology and Infection Research, University of Edinburgh, United Kingdom
    J Immunol 179:4626-34. 2007
    ..This work suggests that during filarial infection CTLA-4 coinhibition and CD4+ CD25+ Treg cells form complementary components of immune regulation that inhibit protective immunity in vivo...
  6. ncbi request reprint Expansion of Foxp3+ regulatory T cells in mice infected with the filarial parasite Brugia malayi
    Henry J McSorley
    Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh, United Kingdom
    J Immunol 181:6456-66. 2008
    ..We conclude that filarial infections significantly skew the balance of the host immune system toward Treg expansion and activation, in a manner dependent on live parasites but independent of a concomitant Th2 response...
  7. ncbi request reprint F4/80+ alternatively activated macrophages control CD4+ T cell hyporesponsiveness at sites peripheral to filarial infection
    Matthew D Taylor
    Institute of Immunology and Infection Research, Ashworth Laboratories, University of Edinburgh, Edinburgh, United Kingdom
    J Immunol 176:6918-27. 2006
    ..Filarial immunosuppression, therefore, evolves over time at sites increasingly distal to infection, and the mechanisms of filarial down-regulation are dependent on proximity to the infection site...
  8. ncbi request reprint Removal of regulatory T cell activity reverses hyporesponsiveness and leads to filarial parasite clearance in vivo
    Matthew D Taylor
    Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh, United Kingdom
    J Immunol 174:4924-33. 2005
    ..These data suggest that regulatory T cells act, in an IL-10-independent manner, to suppress host immunity to filariasis...
  9. pmc Helminth-induced CD19+CD23hi B cells modulate experimental allergic and autoimmune inflammation
    Mark S Wilson
    Centre for Immunity, Infection and Evolution, and Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh, UK
    Eur J Immunol 40:1682-96. 2010
    ..These data expand previous observations and highlight the broad regulatory environment that develops during helminth infections that can abate diverse inflammatory disorders in vivo...
  10. pmc Expansion and activation of CD4(+)CD25(+) regulatory T cells in Heligmosomoides polygyrus infection
    Constance A M Finney
    Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh, UK
    Eur J Immunol 37:1874-86. 2007
    ....
  11. ncbi request reprint IL-4R signaling is required to induce IL-10 for the establishment of T(h)2 dominance
    Adam Balic
    Institute of Immunology and Infection Research, Ashworth Laboratories, West Mains Road, University of Edinburgh, EH9 3JT, UK
    Int Immunol 18:1421-31. 2006
    ..We conclude that T(h)2 cell development in response to N. brasiliensis antigen requires both IL-4 and IL-10 to act in concert on incipient populations of both T(h)1 and T(h)2 types...
  12. pmc ICOS controls Foxp3(+) regulatory T-cell expansion, maintenance and IL-10 production during helminth infection
    Stephen A Redpath
    Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh, UK Centre for Immunity, Infection and Evolution, School of Biological Sciences, University of Edinburgh, Edinburgh, UK
    Eur J Immunol 43:705-15. 2013
    ..Thus, ICOS regulates Type 2 immunity in a tissue-specific manner, and plays a key role in driving Foxp3 Treg-cell expansion and function during helminth infections...
  13. ncbi request reprint Quantitative appraisal of murine filariasis confirms host strain differences but reveals that BALB/c females are more susceptible than males to Litomosoides sigmodontis
    Andrea L Graham
    Institute of Evolution, School of Biological Sciences, University of Edinburgh, King s Buildings, Ashworth Laboratories, Edinburgh EH9 3JT, UK
    Microbes Infect 7:612-8. 2005
    ..In summary, this study has significantly refined our understanding of the host-L. sigmodontis relationship and, critically, has challenged the dogma that males are more susceptible to filarial infection...
  14. pmc Th2 responses to helminth parasites can be therapeutically enhanced by, but are not dependent upon, GITR-GITR ligand costimulation in vivo
    Nienke Van Der Werf
    Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JT, United Kingdom
    J Immunol 187:1411-20. 2011
    ....
  15. pmc Suppression of allergic airway inflammation by helminth-induced regulatory T cells
    Mark S Wilson
    Institute of Immunology and Infection Research, University of Edinburgh, UK
    J Exp Med 202:1199-212. 2005
    ..These data support the contention that helminth infections elicit a regulatory T cell population able to down-regulate allergen induced lung pathology in vivo...
  16. pmc Chitinase and Fizz family members are a generalized feature of nematode infection with selective upregulation of Ym1 and Fizz1 by antigen-presenting cells
    Meera G Nair
    Ashworth Laboratories, University of Edinburgh, Edinburgh EH9 3JT, United Kingdom
    Infect Immun 73:385-94. 2005
    ..ChaFFs may therefore be important effector or wound-repair molecules at the site of nematode infection, with potential regulatory roles for Ym1 and Fizz1 in the draining lymph nodes...
  17. ncbi request reprint Vaccination against filarial nematodes with irradiated larvae provides long-term protection against the third larval stage but not against subsequent life cycle stages
    Simon A Babayan
    Parasitologie comparée et modèles expérimentaux, Museum national d histoire naturelle, 75005 Paris, France
    Int J Parasitol 36:903-14. 2006
    ..Thus, long-term vaccination protocols generated a strong memory response that led to significant but incomplete protection that was limited to the infective larval stage suggesting alternative vaccination strategies are needed...
  18. ncbi request reprint Ethyl pyruvate enhances ATP levels, reduces oxidative stress and preserves cardiac function in a rat model of off-pump coronary bypass
    Matthew D Taylor
    University of Pennsylvania School of Medicine, Division of Cardiothoracic Surgery, Department of Surgery, Silverstein 4, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Heart Lung Circ 14:25-31. 2005
    ..The purpose of this study was to investigate the efficacy of ethyl pyruvate as a myocardial protective agent in a rat model of off-pump coronary artery bypass grafting associated with transient myocardial dysfunction without infarction...