Martin S Taylor

Summary

Affiliation: University of Oxford
Country: UK

Publications

  1. pmc Sushi gets serious: the draft genome sequence of the pufferfish Fugu rubripes
    Martin S Taylor
    MRC Human Genetics Unit, Western General Hospital, Edinburgh, UK
    Genome Biol 3:reviews1025. 2002
  2. ncbi Evolutionary constraints on the Disrupted in Schizophrenia locus
    Martin S Taylor
    Medical Genetics Section, Molecular Medicine Centre, University of Edinburgh, Crewe Road, Edinburgh EH4 2XU, UK
    Genomics 81:67-77. 2003
  3. pmc Occurrence and consequences of coding sequence insertions and deletions in Mammalian genomes
    Martin S Taylor
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK
    Genome Res 14:555-66. 2004
  4. pmc Dynamic and physical clustering of gene expression during epidermal barrier formation in differentiating keratinocytes
    Jennifer M Taylor
    Wellcome Trust Centre for Human Genetics, Oxford, England
    PLoS ONE 4:e7651. 2009
  5. pmc Pervasive haplotypic variation in the spliceo-transcriptome of the human major histocompatibility complex
    Claire Vandiedonck
    Wellcome Trust Centre for Human Genetics, Oxford University, Oxford, UK
    Genome Res 21:1042-54. 2011
  6. pmc Heterotachy in mammalian promoter evolution
    Martin S Taylor
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
    PLoS Genet 2:e30. 2006
  7. pmc A high-resolution single nucleotide polymorphism genetic map of the mouse genome
    Sagiv Shifman
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
    PLoS Biol 4:e395. 2006
  8. doi Singleton SNPs in the human genome and implications for genome-wide association studies
    Xiayi Ke
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Eur J Hum Genet 16:506-15. 2008
  9. pmc Identification of common genetic variation that modulates alternative splicing
    Jeremy Hull
    University Department of Paediatrics, John Radcliffe Hospital, Oxford, United Kingdom
    PLoS Genet 3:e99. 2007
  10. pmc Heterozygous Loss-of-Function Mutations in YAP1 Cause Both Isolated and Syndromic Optic Fissure Closure Defects
    Kathleen A Williamson
    Medical Research Council Human Genetics Unit, Medical Research Council Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK
    Am J Hum Genet 94:295-302. 2014

Detail Information

Publications21

  1. pmc Sushi gets serious: the draft genome sequence of the pufferfish Fugu rubripes
    Martin S Taylor
    MRC Human Genetics Unit, Western General Hospital, Edinburgh, UK
    Genome Biol 3:reviews1025. 2002
    ..The publication of the Fugu rubripes draft genome sequence will take this fish from culinary delicacy to potent tool in deciphering the mysteries of human genome function...
  2. ncbi Evolutionary constraints on the Disrupted in Schizophrenia locus
    Martin S Taylor
    Medical Genetics Section, Molecular Medicine Centre, University of Edinburgh, Crewe Road, Edinburgh EH4 2XU, UK
    Genomics 81:67-77. 2003
    ..The amino acid sequence of DISC1 is diverging rapidly, although a putative nuclear localization signal and discrete blocks of coiled coil are specifically conserved features...
  3. pmc Occurrence and consequences of coding sequence insertions and deletions in Mammalian genomes
    Martin S Taylor
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK
    Genome Res 14:555-66. 2004
    ..There is a specific enrichment of CpG dinucleotides in close proximity to insertion events, and both insertions and deletions are more common in higher G+C content sequences...
  4. pmc Dynamic and physical clustering of gene expression during epidermal barrier formation in differentiating keratinocytes
    Jennifer M Taylor
    Wellcome Trust Centre for Human Genetics, Oxford, England
    PLoS ONE 4:e7651. 2009
    ..The findings provide a reference for subsequent understanding of how the barrier functions in health and disease...
  5. pmc Pervasive haplotypic variation in the spliceo-transcriptome of the human major histocompatibility complex
    Claire Vandiedonck
    Wellcome Trust Centre for Human Genetics, Oxford University, Oxford, UK
    Genome Res 21:1042-54. 2011
    ....
  6. pmc Heterotachy in mammalian promoter evolution
    Martin S Taylor
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
    PLoS Genet 2:e30. 2006
    ....
  7. pmc A high-resolution single nucleotide polymorphism genetic map of the mouse genome
    Sagiv Shifman
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
    PLoS Biol 4:e395. 2006
    ..Genetic maps are available from http://gscan.well.ox.ac.uk/#genetic_map and as supporting information to this publication...
  8. doi Singleton SNPs in the human genome and implications for genome-wide association studies
    Xiayi Ke
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Eur J Hum Genet 16:506-15. 2008
    ....
  9. pmc Identification of common genetic variation that modulates alternative splicing
    Jeremy Hull
    University Department of Paediatrics, John Radcliffe Hospital, Oxford, United Kingdom
    PLoS Genet 3:e99. 2007
    ..Our findings suggest that phenotypic variation in splicing patterns is determined by the presence of SNPs within flanking introns or exons. Effects on splicing may represent an important mechanism by which SNPs influence gene function...
  10. pmc Heterozygous Loss-of-Function Mutations in YAP1 Cause Both Isolated and Syndromic Optic Fissure Closure Defects
    Kathleen A Williamson
    Medical Research Council Human Genetics Unit, Medical Research Council Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK
    Am J Hum Genet 94:295-302. 2014
    ..1066G>T mutation in family 132 should result in NMD in transcripts from either TSS. Amelioration of the phenotype by the alternative transcripts provides a plausible explanation for the phenotypic differences between the families. ..
  11. pmc Quantifying single nucleotide variant detection sensitivity in exome sequencing
    Alison M Meynert
    MRC Human Genetics Unit, MRC Institute for Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Crewe Road, Edinburgh, UK
    BMC Bioinformatics 14:195. 2013
    ..To fully interpret the polymorphisms identified in a genetic study it is often essential to both detect polymorphisms and to understand where and with what probability real polymorphisms may have been missed...
  12. ncbi Genome-wide genetic association of complex traits in heterogeneous stock mice
    William Valdar
    Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
    Nat Genet 38:879-87. 2006
    ..Our data set, freely available at http://gscan.well.ox.ac.uk, provides an entry point to the functional characterization of genes involved in many complex traits...
  13. pmc Genetic analysis of pathways regulated by the von Hippel-Lindau tumor suppressor in Caenorhabditis elegans
    Tammie Bishop
    The Henry Wellcome Building of Genomic Medicine, University of Oxford, Oxford, United Kingdom
    PLoS Biol 2:e289. 2004
    ....
  14. pmc The extracellular matrix gene Frem1 is essential for the normal adhesion of the embryonic epidermis
    Ian Smyth
    Medical Research Council Human Genetics Unit, Crewe Road, Edinburgh EH4 2XU, Scotland, United Kingdom
    Proc Natl Acad Sci U S A 101:13560-5. 2004
    ....
  15. ncbi Monoallelic and Biallelic Mutations in MAB21L2 Cause a Spectrum of Major Eye Malformations
    Joe Rainger
    Medical Research Council Human Genetics Unit, Medical Research Council Institute of Genetics and Molecular Medicine, Edinburgh EH4 2XU, UK
    Am J Hum Genet 94:915-23. 2014
    ..The phenotype associated with the homozygous mutation might be a consequence of complete loss of MAB21L2 RNA binding, although the cellular function of this interaction remains unknown. ..
  16. ncbi Sequence characterization of teleost fish melanocortin receptors
    Darren W Logan
    MRC Human Genetics Unit, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, United Kingdom
    Ann N Y Acad Sci 994:319-30. 2003
    ..We have confirmed the sequences of these 10 genes and show the comparison of the amino acid sequences of the encoded proteins with the orthologous receptor in other vertebrates...
  17. ncbi Interaction of the anaphase-promoting complex/cyclosome and proteasome protein complexes with multiubiquitin chain-binding proteins
    Michael Seeger
    Medical Research Council Human Genetics Unit, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, United Kingdom
    J Biol Chem 278:16791-6. 2003
    ..The putative role of Pus1 as a factor involved in allocation of ubiquitinylated substrates for the proteasome is discussed...
  18. ncbi Genome sequence of the Brown Norway rat yields insights into mammalian evolution
    Richard A Gibbs
    Human Genome Sequencing Center, Department of Molecular and Human Genetics, Baylor College of Medicine, MS BCM226, One Baylor Plaza, Houston, Texas 77030, USA lt http www hgsc bcm tmc edu
    Nature 428:493-521. 2004
    ....
  19. pmc Genomic anatomy of the Tyrp1 (brown) deletion complex
    Ian M Smyth
    Medical Research Council Human Genetics Unit, Edinburgh EH4 2XU, United Kingdom
    Proc Natl Acad Sci U S A 103:3704-9. 2006
    ..This study provides a molecular insight into the basis of several characterized mouse mutants, which will allow further dissection of this region by targeted or chemical mutagenesis...
  20. ncbi The structure and evolution of the melanocortin and MCH receptors in fish and mammals
    Darren W Logan
    MRC Human Genetics Unit, Western General Hospital, Edinburgh, EH4 2XU, UK
    Genomics 81:184-91. 2003
    ..Unlike other species, we find the Fugu genes contain introns, one of which is in a conserved location and is probably ancestral. We also detail the differential expression of the zebrafish genes throughout development...
  21. ncbi Genome-wide analysis of mammalian promoter architecture and evolution
    Piero Carninci
    Genome Exploration Research Group, RIKEN Genomic Sciences Center, RIKEN Yokohama Institute, 1 7 22 Suehiro cho, Tsurumi ku, Yokohama, Kanagawa, 230 0045, Japan
    Nat Genet 38:626-35. 2006
    ..These data permit genome-scale identification of tissue-specific promoters and analysis of the cis-acting elements associated with them...