M J Taylor

Summary

Affiliation: University of Liverpool
Country: UK

Publications

  1. doi request reprint Lymphatic filariasis and onchocerciasis
    Mark J Taylor
    Liverpool School of Tropical Medicine, Liverpool, UK
    Lancet 376:1175-85. 2010
  2. pmc Community-directed delivery of doxycycline for the treatment of onchocerciasis in areas of co-endemicity with loiasis in Cameroon
    Samuel Wanji
    Department of Biochemistry and Microbiology, University of Buea, P, O, Box 63, Buea Cameroon
    Parasit Vectors 2:39. 2009
  3. pmc Lipoprotein biosynthesis as a target for anti-Wolbachia treatment of filarial nematodes
    Kelly L Johnston
    Filariasis Research Laboratory, Molecular and Biochemical Parasitology Group, Liverpool School of Tropical Medicine, Liverpool, L3 5QA, UK
    Parasit Vectors 3:99. 2010
  4. ncbi request reprint A new insight into the pathogenesis of filarial disease
    Mark J Taylor
    Liverpool School of Tropical Medicine, UK
    Curr Mol Med 2:299-302. 2002
  5. ncbi request reprint Wolbachia in the inflammatory pathogenesis of human filariasis
    Mark J Taylor
    Filariasis Research Laboratory, Division of Molecular and Biochemical Parasitology, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L3 5QA, UK
    Ann N Y Acad Sci 990:444-9. 2003
  6. ncbi request reprint A new approach to the treatment of filariasis
    M J Taylor
    Liverpool School of Tropical Medicine, Liverpool, UK
    Curr Opin Infect Dis 14:727-31. 2001
  7. pmc Absence of Wolbachia endobacteria in the non-filariid nematodes Angiostrongylus cantonensis and A. costaricensis
    Jeremy M Foster
    Molecular and Biochemical Parasitology, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK
    Parasit Vectors 1:31. 2008
  8. ncbi request reprint Severe reactions to filarial chemotherapy and release of Wolbachia endosymbionts into blood
    H F Cross
    Liverpool School of Tropical Medicine, Pembroke Place, L3 5QA, Liverpool, UK
    Lancet 358:1873-5. 2001
  9. ncbi request reprint Wolbachia endosymbiotic bacteria of filarial nematodes. A new insight into disease pathogenesis and control
    Mark J Taylor
    Division of Molecular and Biochemical Parasitology, Liverpool School of Tropical Medicine, Liverpool, UK
    Arch Med Res 33:422-4. 2002
  10. pmc Inflammatory responses induced by the filarial nematode Brugia malayi are mediated by lipopolysaccharide-like activity from endosymbiotic Wolbachia bacteria
    M J Taylor
    Cellular Immunology Laboratory, Division of Molecular Biology and Immunology, Liverpool School of Tropical Medicine, Liverpool L3 5QA, United Kingdom
    J Exp Med 191:1429-36. 2000

Collaborators

Detail Information

Publications37

  1. doi request reprint Lymphatic filariasis and onchocerciasis
    Mark J Taylor
    Liverpool School of Tropical Medicine, Liverpool, UK
    Lancet 376:1175-85. 2010
    ..Global programmes for control and elimination have been developed to provide sustained delivery of drugs to affected communities to interrupt transmission of disease and ultimately eliminate this burden on public health...
  2. pmc Community-directed delivery of doxycycline for the treatment of onchocerciasis in areas of co-endemicity with loiasis in Cameroon
    Samuel Wanji
    Department of Biochemistry and Microbiology, University of Buea, P, O, Box 63, Buea Cameroon
    Parasit Vectors 2:39. 2009
    ..abstract:..
  3. pmc Lipoprotein biosynthesis as a target for anti-Wolbachia treatment of filarial nematodes
    Kelly L Johnston
    Filariasis Research Laboratory, Molecular and Biochemical Parasitology Group, Liverpool School of Tropical Medicine, Liverpool, L3 5QA, UK
    Parasit Vectors 3:99. 2010
    ..abstract:..
  4. ncbi request reprint A new insight into the pathogenesis of filarial disease
    Mark J Taylor
    Liverpool School of Tropical Medicine, UK
    Curr Mol Med 2:299-302. 2002
    ..It may be possible, through the use of antibiotic therapy, to clear worms of their bacteria, in the hope that this will prevent the onset and development of filarial pathology...
  5. ncbi request reprint Wolbachia in the inflammatory pathogenesis of human filariasis
    Mark J Taylor
    Filariasis Research Laboratory, Division of Molecular and Biochemical Parasitology, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L3 5QA, UK
    Ann N Y Acad Sci 990:444-9. 2003
    ..The use of antibiotic therapy to target Wolbachia of filarial parasites may therefore provide a means to prevent the development of filarial pathology...
  6. ncbi request reprint A new approach to the treatment of filariasis
    M J Taylor
    Liverpool School of Tropical Medicine, Liverpool, UK
    Curr Opin Infect Dis 14:727-31. 2001
    ..Since Wolbachia also contribute to the inflammatory pathogenesis of filarial disease, antibiotic therapy could, in addition to effects on worm fertility or viability, prevent the onset or development of filarial pathology...
  7. pmc Absence of Wolbachia endobacteria in the non-filariid nematodes Angiostrongylus cantonensis and A. costaricensis
    Jeremy M Foster
    Molecular and Biochemical Parasitology, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK
    Parasit Vectors 1:31. 2008
    ..This study demonstrates the need for caution in relying solely on PCR for identification of new endosymbiont strains from invertebrate DNA samples...
  8. ncbi request reprint Severe reactions to filarial chemotherapy and release of Wolbachia endosymbionts into blood
    H F Cross
    Liverpool School of Tropical Medicine, Pembroke Place, L3 5QA, Liverpool, UK
    Lancet 358:1873-5. 2001
    ..We suggest that these severe inflammatory reactions are associated with the release of endosymbionts into the blood after treatment for filariasis...
  9. ncbi request reprint Wolbachia endosymbiotic bacteria of filarial nematodes. A new insight into disease pathogenesis and control
    Mark J Taylor
    Division of Molecular and Biochemical Parasitology, Liverpool School of Tropical Medicine, Liverpool, UK
    Arch Med Res 33:422-4. 2002
    ..In addition to the uncovering of a fascinating symbiotic relationship, this discovery means we can now consider using antibiotics as a new approach to the treatment of filarial diseases...
  10. pmc Inflammatory responses induced by the filarial nematode Brugia malayi are mediated by lipopolysaccharide-like activity from endosymbiotic Wolbachia bacteria
    M J Taylor
    Cellular Immunology Laboratory, Division of Molecular Biology and Immunology, Liverpool School of Tropical Medicine, Liverpool L3 5QA, United Kingdom
    J Exp Med 191:1429-36. 2000
    ..Thus, Wolbachia LPS may be one of the major mediators of inflammatory pathogenesis in filarial nematode disease...
  11. ncbi request reprint Wolbachia bacteria of filarial nematodes
    M J Taylor
    Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, UK L3 5QA
    Parasitol Today 15:437-42. 1999
    ....
  12. pmc Onchocerciasis Control: Vision for the Future from a Ghanian perspective
    Mark J Taylor
    Molecular and Biochemical Parasitology, Liverpool School of Tropical Medicine, Liverpool, UK
    Parasit Vectors 2:7. 2009
    ....
  13. ncbi request reprint Wolbachia bacteria in filarial immunity and disease
    M J Taylor
    Cellular Immunology Laboratory, Division of Molecular Biology and Immunology, Liverpool School of Tropical Medicine, Liverpool, UK
    Parasite Immunol 23:401-9. 2001
    ..The recognition of the contribution of endosymbiotic bacteria to filarial disease could be exploited for clinical intervention by the targeting of bacteria with antibiotics in an attempt to reduce the development of filarial pathology...
  14. pmc Down-regulated lymphoproliferation coincides with parasite maturation and with the collapse of both gamma interferon and interleukin-4 responses in a bovine model of onchocerciasis
    S P Graham
    Liverpool School of Tropical Medicine, Liverpool L3 5QA, United Kingdom
    Infect Immun 69:4313-9. 2001
    ..The natural host-parasite relationship of O. ochengi in cattle may be useful as both a descriptive and predictive tool to test more refined models of immunomodulation in onchocerciasis...
  15. ncbi request reprint Eosinophils are the major effector cells of immunity to microfilariae in a mouse model of onchocerciasis
    S G Folkard
    Liverpool School of Tropical Medicine, UK
    Parasitology 112:323-9. 1996
    ..This report describes the first direct evidence for eosinophil-mediated killing of microfilariae in vivo, and is consistent with Th-2 cell responses previously described in this model...
  16. ncbi request reprint Wolbachia bacterial endosymbionts of filarial nematodes
    Mark J Taylor
    Filariasis Research Laboratory, Molecular and Biochemical Parasitology, Liverpool School of Tropical Medicine, Liverpool, L3 5QA, UK
    Adv Parasitol 60:245-84. 2005
    ....
  17. pmc Tropomyosin implicated in host protective responses to microfilariae in onchocerciasis
    R E Jenkins
    Division of Molecular Biology and Immunology, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L3 5QA, United Kingdom
    Proc Natl Acad Sci U S A 95:7550-5. 1998
    ....
  18. ncbi request reprint Population dynamics of Wolbachia bacterial endosymbionts in Brugia malayi
    Helen F McGarry
    Filariasis Research Laboratory, Molecular and Biochemical Parasitology, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK
    Mol Biochem Parasitol 135:57-67. 2004
    ..These results support the hypothesis that the bacteria are essential for larval development in the mammalian host and for the long-term survival of adult worms...
  19. doi request reprint Current practices in the management of lymphatic filariasis
    Moses J Bockarie
    Centre for Neglected Tropical Diseases, Liverpool School of Tropical Medicine, Liverpool, UK
    Expert Rev Anti Infect Ther 7:595-605. 2009
    ..The role of integrated vector management as a supplementary strategy for mass drug administration and new strategies for treatment and morbidity control through antibiotic targeting of the Wolbachia endosymbionts are also discussed...
  20. ncbi request reprint Macrofilaricidal activity after doxycycline treatment of Wuchereria bancrofti: a double-blind, randomised placebo-controlled trial
    Mark J Taylor
    Filariasis Research Group, Molecular and Biochemical Parasitology, Liverpool School of Tropical Medicine, Liverpool, UK
    Lancet 365:2116-21. 2005
    ..We used this strategy to investigate the effects of doxycycline treatment on the major cause of lymphatic filariasis, Wuchereria bancrofti...
  21. ncbi request reprint IL-5-dependent immunity to microfilariae is independent of IL-4 in a mouse model of onchocerciasis
    P J Hogarth
    Division of Molecular Biology and Immunology, Liverpool School of Tropical Medicine, United Kingdom
    J Immunol 160:5436-40. 1998
    ..Importantly, they also segregate T cell-mediated mechanisms of protective immunity from those characterized in ocular pathologic responses in onchocerciasis, which are dependent on IL-4...
  22. ncbi request reprint Current status and future prospects of the Global Lymphatic Filariasis Programme
    D H Molyneux
    Liverpool School of Tropical Medicine, Liverpool, UK
    Curr Opin Infect Dis 14:155-9. 2001
    ..Herein we review the current status and future prospects of the Global Lymphatic Filariasis Programme, which was launched in 2000...
  23. ncbi request reprint Wolbachia endosymbiotic bacteria of Brugia malayi mediate macrophage tolerance to TLR- and CD40-specific stimuli in a MyD88/TLR2-dependent manner
    Joseph D Turner
    Filariasis Research Laboratory, Molecular and Biochemical Parasitology, Liverpool School of Tropical Medicine, Pembroke Place, L3 5QA Liverpool, United Kingdom
    J Immunol 177:1240-9. 2006
    ..Our data promote a role for Wolbachia in contributing toward the dysregulated and tolerized immunological phenotype that accompanies the majority of human filarial infections...
  24. pmc Wolbachia lipoprotein stimulates innate and adaptive immunity through Toll-like receptors 2 and 6 to induce disease manifestations of filariasis
    Joseph D Turner
    Filariasis Research Laboratory, Molecular and Biochemical Parasitology, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, United Kingdom
    J Biol Chem 284:22364-78. 2009
    ..Thus, in addition to innate inflammatory activation, Wolbachia lipoproteins drive interferon-gamma-dependent CD4+ T cell polarization and antibody switching...
  25. ncbi request reprint Mass drug treatment for lymphatic filariasis and onchocerciasis
    David H Molyneux
    Lymphatic Filariasis Support Centre, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK
    Trends Parasitol 19:516-22. 2003
  26. ncbi request reprint Accelerated clearance of Onchocerca microfilariae and resistance to reinfection in interleukin-4 gene knockout mice
    P J Hogarth
    Liverpool School of Tropical Medicine, UK
    Parasite Immunol 17:653-7. 1995
    ..The data presented here suggest that elimination of mf can occur independent of IL-4 and that in this model it may even be detrimental to the host...
  27. ncbi request reprint A randomized, double-blind clinical trial of a 3-week course of doxycycline plus albendazole and ivermectin for the treatment of Wuchereria bancrofti infection
    Joseph D Turner
    Liverpool School of Tropical Medicine, Liverpool, United Kingdom
    Clin Infect Dis 42:1081-9. 2006
    ..We assessed whether a shorter (i.e, 3-week) course of doxycycline with standard treatment would show superior efficacy to standard treatment alone and reduce the incidence of adverse reactions...
  28. pmc Macrofilaricidal activity after doxycycline only treatment of Onchocerca volvulus in an area of Loa loa co-endemicity: a randomized controlled trial
    Joseph D Turner
    Filariasis Research Laboratory, Molecular and Biochemical Parasitology, Liverpool School of Tropical Medicine, Liverpool, United Kingdom
    PLoS Negl Trop Dis 4:e660. 2010
    ..Furthermore we assessed the safety of doxycycline treatment prior to ivermectin administration in a subset of onchocerciasis individuals co-infected with low to moderate intensities of Loa loa microfilaraemia...
  29. ncbi request reprint The role of endosymbiotic Wolbachia bacteria in the pathogenesis of river blindness
    Amélie v Saint André
    Division of Geographic Medicine, Department of Ophthalmology, University Hospitals of Cleveland and Case Western Reserve University, Cleveland, OH 44106, USA
    Science 295:1892-5. 2002
    ..In addition, the inflammatory response induced by these bacteria was dependent on expression of functional Toll-like receptor 4 (TLR4) on host cells...
  30. ncbi request reprint Bacterial endosymbionts of Onchocerca volvulus in the pathogenesis of posttreatment reactions
    Paul B Keiser
    Helminth Immunology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Infect Dis 185:805-11. 2002
    ..021) and calgranulin B (P <.0001). These findings support a role for Wolbachia products in mediating the inflammatory responses seen following treatment of onchocerciasis and suggest new targets for modulating these reactions...
  31. pmc Wolbachia endobacteria depletion by doxycycline as antifilarial therapy has macrofilaricidal activity in onchocerciasis: a randomized placebo-controlled study
    Achim Hoerauf
    Institute for Medical Microbiology, Immunology and Parasitology, University Clinic, Bonn, Sigmund Freud Strasse 25, Bonn, Germany
    Med Microbiol Immunol 197:295-311. 2008
    ..Doxycycline may be developed as second-line drug for onchocerciasis, to be administered in areas without transmission, in foci with IVM resistance and in areas with Loa co-infections...
  32. ncbi request reprint Innate immune responses to endosymbiotic Wolbachia bacteria in Brugia malayi and Onchocerca volvulus are dependent on TLR2, TLR6, MyD88, and Mal, but not TLR4, TRIF, or TRAM
    Amy G Hise
    Center for Global Health and Diseases and Department of Ophthalmology, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA
    J Immunol 178:1068-76. 2007
    ..These results establish that the innate inflammatory pathways activated by endosymbiotic Wolbachia in B. malayi and O. volvulus filaria are dependent on TLR2-TLR6 interactions and are mediated by adaptor molecules MyD88 and TIRAP/Mal...
  33. pmc Culture and phenotypic characterization of a Wolbachia pipientis isolate
    Florence Fenollar
    Unite des Rickettsies, Universite de la Mediterranee, Faculte de Medecine, CNRS UPRESA 6020, 13385 Marseille, France
    J Clin Microbiol 41:5434-41. 2003
    ....
  34. pmc Wolbachia- and Onchocerca volvulus-induced keratitis (river blindness) is dependent on myeloid differentiation factor 88
    Illona Gillette-Ferguson
    Department of Ophthalmology, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106 7286, USA
    Infect Immun 74:2442-5. 2006
    ..The current study demonstrates that corneal inflammation induced by Wolbachia or O. volvulus antigens containing Wolbachia is completely dependent on expression of myeloid differentiation factor 88...
  35. doi request reprint Doxycycline treatment of Brugia malayi-infected persons reduces microfilaremia and adverse reactions after diethylcarbamazine and albendazole treatment
    Taniawati Supali
    Department of Parasitology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia
    Clin Infect Dis 46:1385-93. 2008
    ..We assessed whether doxycycline alone or in combination with diethylcarbamazine-albendazole would lead to sustained amicrofilaremia and reduced incidence of adverse reactions...
  36. pmc Wolbachia-induced neutrophil activation in a mouse model of ocular onchocerciasis (river blindness)
    Illona Gillette-Ferguson
    Department of Ophthalmology, Case Western Reserve University, Cleveland, Ohio 44106 4983, USA
    Infect Immun 72:5687-92. 2004
    ..Taken together, these findings indicate that neutrophil activation is an important mechanism by which Wolbachia organisms contribute to the pathogenesis of ocular onchocerciasis...
  37. pmc Toll-like receptor 2 regulates CXC chemokine production and neutrophil recruitment to the cornea in Onchocerca volvulus/Wolbachia-induced keratitis
    Illona Gillette-Ferguson
    Department of Ophthalmology, Case Western Reserve University, Cleveland, OH 44106 7286, USA
    Infect Immun 75:5908-15. 2007
    ..volvulus/Wolbachia-induced neutrophil activation and development of corneal haze...