Deniz Tasdemir

Summary

Affiliation: University of London
Country: UK

Publications

  1. ncbi request reprint Evaluation of antiprotozoal and antimycobacterial activities of the resin glycosides and the other metabolites of Scrophularia cryptophila
    Deniz Tasdemir
    Centre for Pharmacognosy and Phytotherapy, School of Pharmacy, University of London, 29 39 Brunswick Square, London WC1N 1AX, UK
    Phytomedicine 15:209-15. 2008
  2. ncbi request reprint Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids
    Deniz Tasdemir
    University of Zurich, Institute of Organic Chemistry, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    J Med Chem 49:3345-53. 2006
  3. ncbi request reprint Marine natural products from the Turkish sponge Agelas oroides that inhibit the enoyl reductases from Plasmodium falciparum, Mycobacterium tuberculosis and Escherichia coli
    Deniz Tasdemir
    Centre for Pharmacognosy and Phytotherapy, School of Pharmacy, University of London, London, UK
    Bioorg Med Chem 15:6834-45. 2007
  4. ncbi request reprint Antituberculotic and antiprotozoal activities of primin, a natural benzoquinone: in vitro and in vivo studies
    Deniz Tasdemir
    Centre for Pharmacognosy and Phytotherapy, School of Pharmacy, University of London, 29 39 Brunswick Square, London WC1N 1AX, UK
    Chem Biodivers 3:1230-7. 2006
  5. pmc 2-Hexadecynoic acid inhibits plasmodial FAS-II enzymes and arrests erythrocytic and liver stage Plasmodium infections
    Deniz Tasdemir
    Department of Pharmaceutical and Biological Chemistry, School of Pharmacy, University of London, 29 39 Brunswick Square, London WC1N 1AX, United Kingdom
    Bioorg Med Chem 18:7475-85. 2010
  6. doi request reprint Antiprotozoal, antimycobacterial and cytotoxic potential of twenty-three British and Irish red algae
    Andrea Allmendinger
    Department of Pharmaceutical and Biological Chemistry, Centre for Pharmacognosy and Phytotherapy, School of Pharmacy, University of London, London WC1N 1AX, UK
    Phytother Res 24:1099-103. 2010
  7. ncbi request reprint Potential of lichen secondary metabolites against Plasmodium liver stage parasites with FAS-II as the potential target
    Ina L Lauinger
    Department of Pharmaceutical and Biological Chemistry, School of Pharmacy, University of London, London WC1N 1AX, UK
    J Nat Prod 76:1064-70. 2013
  8. doi request reprint Antiprotozoal, antimycobacterial and cytotoxic potential of some british green algae
    Jasmine Spavieri
    Department of Pharmaceutical and Biological Chemistry, Centre for Pharmacognosy and Phytotherapy, School of Pharmacy, University of London, London WC1N 1AX, UK
    Phytother Res 24:1095-8. 2010
  9. ncbi request reprint Antiprotozoal, antitubercular and cytotoxic potential of cyanobacterial (blue-green algal) extracts from Ireland
    Barbara Broniatowska
    Department of Pharmaceutical and Biological Chemistry, Centre for Pharmacognosy and Phytotherapy, School of Pharmacy, University of London, London WC1N 1AX, UK
    Nat Prod Commun 6:689-94. 2011
  10. pmc Assessment of dual life stage antiplasmodial activity of british seaweeds
    Jasmine Spavieri
    Department of Pharmaceutical and Biological Chemistry, School of Pharmacy, University of London, London WC1N 1AX, UK
    Mar Drugs 11:4019-34. 2013

Collaborators

Detail Information

Publications23

  1. ncbi request reprint Evaluation of antiprotozoal and antimycobacterial activities of the resin glycosides and the other metabolites of Scrophularia cryptophila
    Deniz Tasdemir
    Centre for Pharmacognosy and Phytotherapy, School of Pharmacy, University of London, 29 39 Brunswick Square, London WC1N 1AX, UK
    Phytomedicine 15:209-15. 2008
    ..This is the first report of antiprotozoal activity for natural resin glycosides, as well as for harpagide (4), acetylharpagide (5), tryptophan (6) and buddlejasaponin III (7)...
  2. ncbi request reprint Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids
    Deniz Tasdemir
    University of Zurich, Institute of Organic Chemistry, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    J Med Chem 49:3345-53. 2006
    ..In addition, these polyphenols showed in vitro activity against chloroquine-sensitive (NF54) and -resistant (K1) P. falciparum strains in the low to submicromolar range...
  3. ncbi request reprint Marine natural products from the Turkish sponge Agelas oroides that inhibit the enoyl reductases from Plasmodium falciparum, Mycobacterium tuberculosis and Escherichia coli
    Deniz Tasdemir
    Centre for Pharmacognosy and Phytotherapy, School of Pharmacy, University of London, London, UK
    Bioorg Med Chem 15:6834-45. 2007
    ..This study represents the first marine metabolites that inhibit FabI, a clinically relevant enzyme target from the FAS-II pathway of several pathogenic microorganisms...
  4. ncbi request reprint Antituberculotic and antiprotozoal activities of primin, a natural benzoquinone: in vitro and in vivo studies
    Deniz Tasdemir
    Centre for Pharmacognosy and Phytotherapy, School of Pharmacy, University of London, 29 39 Brunswick Square, London WC1N 1AX, UK
    Chem Biodivers 3:1230-7. 2006
    ..p. route) in mice infected with L. donovani. Taken together, primin can serve as a lead compound for the rational design of more potent and less toxic antiprotozoal agents...
  5. pmc 2-Hexadecynoic acid inhibits plasmodial FAS-II enzymes and arrests erythrocytic and liver stage Plasmodium infections
    Deniz Tasdemir
    Department of Pharmaceutical and Biological Chemistry, School of Pharmacy, University of London, 29 39 Brunswick Square, London WC1N 1AX, United Kingdom
    Bioorg Med Chem 18:7475-85. 2010
    ..The lack of cytotoxicity, lipophilic nature, and calculated pharmacokinetic properties suggests that 2-HDA could be a useful compound to study the interaction of fatty acids with these key P. falciparum enzymes...
  6. doi request reprint Antiprotozoal, antimycobacterial and cytotoxic potential of twenty-three British and Irish red algae
    Andrea Allmendinger
    Department of Pharmaceutical and Biological Chemistry, Centre for Pharmacognosy and Phytotherapy, School of Pharmacy, University of London, London WC1N 1AX, UK
    Phytother Res 24:1099-103. 2010
    ..6 microg/ml), and all remaining extracts were non-toxic towards L6 cells at 90 microg/ml concentration. To our knowledge, this is the first study reporting antiprotozoal and antimycobacterial activity of British and Irish red algae...
  7. ncbi request reprint Potential of lichen secondary metabolites against Plasmodium liver stage parasites with FAS-II as the potential target
    Ina L Lauinger
    Department of Pharmaceutical and Biological Chemistry, School of Pharmacy, University of London, London WC1N 1AX, UK
    J Nat Prod 76:1064-70. 2013
    ..This study indicates the therapeutic and prophylactic potential of lichen metabolites as antibacterial and antiplasmodial agents. ..
  8. doi request reprint Antiprotozoal, antimycobacterial and cytotoxic potential of some british green algae
    Jasmine Spavieri
    Department of Pharmaceutical and Biological Chemistry, Centre for Pharmacognosy and Phytotherapy, School of Pharmacy, University of London, London WC1N 1AX, UK
    Phytother Res 24:1095-8. 2010
    ..2 microg/ml. None of the extracts showed cytotoxicity toward L6 cells, indicating that their antiprotozoal activity is specific. This is the first study reporting antiprotozoal and antimycobacterial activity of British marine algae...
  9. ncbi request reprint Antiprotozoal, antitubercular and cytotoxic potential of cyanobacterial (blue-green algal) extracts from Ireland
    Barbara Broniatowska
    Department of Pharmaceutical and Biological Chemistry, Centre for Pharmacognosy and Phytotherapy, School of Pharmacy, University of London, London WC1N 1AX, UK
    Nat Prod Commun 6:689-94. 2011
    ..These results warrant the further study of Irish terrestrial cyanobacteria as a valuable source of new natural product leads for the treatment of parasitic protozoal infections...
  10. pmc Assessment of dual life stage antiplasmodial activity of british seaweeds
    Jasmine Spavieri
    Department of Pharmaceutical and Biological Chemistry, School of Pharmacy, University of London, London WC1N 1AX, UK
    Mar Drugs 11:4019-34. 2013
    ..This is the first report of LS antiplasmodial activity and dual stage inhibitory potential of seaweeds...
  11. pmc Antitrypanosomal and antileishmanial activities of flavonoids and their analogues: in vitro, in vivo, structure-activity relationship, and quantitative structure-activity relationship studies
    Deniz Tasdemir
    Institute of Organic Chemistry, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Antimicrob Agents Chemother 50:1352-64. 2006
    ..However, our results can help in directing the rational design of 7,8-dihydroxyflavone and quercetin derivatives as potent and effective antiprotozoal agents...
  12. ncbi request reprint Anti-protozoal and plasmodial FabI enzyme inhibiting metabolites of Scrophularia lepidota roots
    Deniz Tasdemir
    Institute of Organic Chemistry, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Phytochemistry 66:355-62. 2005
    ..Only compound 10 showed moderate anti-plasmodial (IC50 40.6 microg/ml) and FabI enzyme inhibitory activity (IC50 100 microg/ml). 10 is the second natural product inhibiting the fatty acid biosynthesis of Plasmodium falciparum...
  13. doi request reprint Antimycobacterial, antiprotozoal and cytotoxic potential of twenty-one brown algae (Phaeophyceae) from British and Irish waters
    Jasmine Spavieri
    Department of Pharmaceutical and Biological Chemistry, Centre for Pharmacognosy and Phytotherapy, School of Pharmacy, University of London, London WC1N 1AX, UK
    Phytother Res 24:1724-9. 2010
    ..e. H. siliquosa, B. bifurcata and Cystoseira tamariscifolia showed some cytotoxicity. To our knowledge, this is the first study on the antiprotozoal and antimycobacterial activity of brown algae from British and Irish waters...
  14. doi request reprint Salvia officinalis for hot flushes: towards determination of mechanism of activity and active principles
    Sinikka Rahte
    Centre for Pharmacognosy and Phytotherapy, School of Pharmacy, University of London, London, United Kingdom
    Planta Med 79:753-60. 2013
    ..This study suggests the involvement of common and ubiquitous estrogenic flavonoids in the anti-hot flush effect of Salvia officinalis, a safe and commonly used herbal medicinal product during the menopause...
  15. ncbi request reprint Inhibiting activities of the secondary metabolites of Phlomis brunneogaleata against parasitic protozoa and plasmodial enoyl-ACP Reductase, a crucial enzyme in fatty acid biosynthesis
    Hasan Kirmizibekmez
    Department of Pharmacognosy, Faculty of Pharmacy, Hacettepe University, Ankara, Turkey
    Planta Med 70:711-7. 2004
    ..falciparum, was also assessed. Compound 10 showed promising FabI inhibiting effect (IC (50) = 10 micrograms/mL) and appears to be the first anti-malarial natural product targeting FabI of P. falciparum...
  16. ncbi request reprint Anthecularin: a novel sesquiterpene lactone from Anthemis auriculata with antiprotozoal activity
    Anastasia Karioti
    Department of Pharmacognosy and Chemistry of Natural Products, School of Pharmacy, University of Athens, 157 71 Athens, Greece
    J Org Chem 72:8103-6. 2007
    ..3 microg/mL) and inhibited two key enzymes of the plasmodial type II fatty acid biosynthesis pathway, PfFabI and PfFabG (IC50 values=14 and 28.3 microg/mL, respectively). A probable biogenesis of 1 is also proposed and discussed...
  17. ncbi request reprint Bioactive isomalabaricane triterpenes from the marine sponge Rhabdastrella globostellata
    Deniz Tasdemir
    Department of Medicinal Chemistry, University of Utah, Salt Lake City, Utah 84112, USA
    J Nat Prod 65:210-4. 2002
    ..Stellettin B (4) and (-)-stellettin E (7) showed selective cytotoxicity toward p21(WAF1/Cip1)-deficient human colon tumor (HCT-116) cells with IC(50) values of 0.043 and 0.039 microM, respectively...
  18. ncbi request reprint Lucidin type anthraquinone glycosides from Putoria calabrica
    Ihsan Calis
    Department of Pharmacognosy, Faculty of Pharmacy, Hacettepe University, Ankara, Turkey
    Chem Pharm Bull (Tokyo) 50:701-2. 2002
    ....
  19. ncbi request reprint Microcionamides A and B, bioactive peptides from the philippine sponge Clathria (Thalysias) abietina
    Rohan A Davis
    Department of Medicinal Chemistry, University of Utah, Salt Lake City, Utah 84112, USA
    J Org Chem 69:4170-6. 2004
    ..Microcionamides A (1) and B (2) exhibited significant cytotoxicity against the human breast tumor cells lines MCF-7 and SKBR-3 and displayed inhibitory activity against Mycobacterium tuberculosis H(37)Ra...
  20. ncbi request reprint Crypthophilic acids A, B, and C: resin glycosides from aerial parts of Scrophularia crypthophila
    Ihsan Calis
    Department of Pharmacognosy, Faculty of Pharmacy, Hacettepe University, TR 06100 Ankara, Turkey
    J Nat Prod 70:43-7. 2007
    ..All natural resin glycosides known so far have been obtained from Convolvulaceae plants; this is the first report of such glycosides from another, taxonomically unrelated family (Scrophulariaceae)...
  21. ncbi request reprint Pseudovibrio denitrificans strain Z143-1, a heptylprodigiosin-producing bacterium isolated from a Philippine tunicate
    Alice A Sertan-de Guzman
    FEMS Microbiol Lett 277:188-96. 2007
    ..While there is no report of a secondary metabolite for Pseudovibrio denitrificans, Z143-1 produces the red pigment heptylprodigiosin, also known as 16-methyl-15-heptyl-prodiginine, which shows anti-Staphylococcus aureus activity...
  22. ncbi request reprint Leishmanicidal cycloartane-type triterpene glycosides from Astragalus oleifolius
    Meltem Ozipek
    Department of Pharmacognosy, Faculty of Pharmacy, Hacettepe University, Ankara, Turkey
    Phytochemistry 66:1168-73. 2005
    ..None of the compounds were toxic to mammalian cells (IC50's > 90 microg/ml). This is the first report of leishmanicidal and trypanocidal activity of cycloartane-type triterpene glycosides...
  23. ncbi request reprint Aldisine alkaloids from the Philippine sponge Stylissa massa are potent inhibitors of mitogen-activated protein kinase kinase-1 (MEK-1)
    Deniz Tasdemir
    Department of Medicinal Chemistry, University of Utah, Salt Lake City, Utah 84112, USA
    J Med Chem 45:529-32. 2002
    ..Both 4 and 5 showed significant enzyme inhibitory activity (IC(50) 3 and 6 nM, respectively). Secondary assays identified these compounds as potent MEK-1 inhibitors. Compounds 4 and 5 also inhibited the growth of human tumor LoVo cells...