Research Topics
| Paul Targett-AdamsSummaryAffiliation: University of Glasgow Country: UK Publications
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Detail Information
Publications
A PPAR response element regulates transcription of the gene for human adipose differentiation-related proteinPaul Targett-Adams
MRC Virology Unit, Institute of Virology, University of Glasgow, Church Street, Glasgow G11 5JR, UK
Biochim Biophys Acta 1728:95-104. 2005..These findings offer insight into the mechanisms which serve to regulate ADRP transcription and intracellular lipid storage...- Development and characterization of a transient-replication assay for the genotype 2a hepatitis C virus subgenomic repliconPaul Targett-Adams
MRC Virology Unit, Institute of Virology, Church Street, Glasgow G11 5JR, UK
J Gen Virol 86:3075-80. 2005..Thus, this system based on JFH1 sequences offers improvements over prior genotype 1b replicons for quantitative measurement of viral RNA replication... 
Comparison of U2OS and Huh-7 cells for identifying host factors that affect hepatitis C virus RNA replicationDaniel M Jones
MRC Virology Unit, Church Street, Glasgow G11 5JR, UK
J Gen Virol 91:2238-48. 2010..Therefore, this study provides an important framework for future detailed analyses of these and other cellular proteins...- Structural determinants that target the hepatitis C virus core protein to lipid dropletsSteeve Boulant
Medical Research Council Virology Unit, Institute of Virology, Church St, Glasgow G11 5JR, Scotland, United Kingdom
J Biol Chem 281:22236-47. 2006..They also serve as a unique model for elucidating the specificity of protein-lipid interactions between two membrane-bound organelles... 
The hepatitis C virus NS4B protein can trans-complement viral RNA replication and modulates production of infectious virusDaniel M Jones
MRC Virology Unit, Church Street, Glasgow G11 5JR, United Kingdom
J Virol 83:2163-77. 2009..Finally, one of the NS4B mutations increased the yield of infectious virus by five- to sixfold. Hence, NS4B not only functions in RNA replication but also contributes to the processes engaged in virus assembly and release...- Hepatitis C virus core protein induces lipid droplet redistribution in a microtubule- and dynein-dependent mannerSteeve Boulant
MRC Virology Unit, Institute of Virology, Church Street, Glasgow G11 5JR, UK
Traffic 9:1268-82. 2008..We propose that the presence of core on LDs favours their movement towards the nucleus, possibly to increase the probability of interaction between sites of HCV RNA replication and virion assembly... - Requirement of cellular DDX3 for hepatitis C virus replication is unrelated to its interaction with the viral core proteinAllan G N Angus
MRC Virology Unit, Institute of Virology, University of Glasgow, Church Street, Glasgow G11 5JR, UK
J Gen Virol 91:122-32. 2010..Thus, our study shows for the first time that the requirement of DDX3 for HCV replication is unrelated to its interaction with the viral core protein... - Maturation of hepatitis C virus core protein by signal peptide peptidase is required for virus productionPaul Targett-Adams
MRC Virology Unit, Institute of Virology, Glasgow G11 5JR, United Kingdom
J Biol Chem 283:16850-9. 2008..Moreover, they offer compelling evidence for a function for an intramembrane protease to facilitate the association of core with viral genomes, thereby creating putative sites for assembly of nascent virus particles... - Disrupting the association of hepatitis C virus core protein with lipid droplets correlates with a loss in production of infectious virusSteeve Boulant
MRC Virology Unit, Institute of Virology, Church Street, Glasgow G11 5JR, UK
J Gen Virol 88:2204-13. 2007..Taken together, our findings indicate that lipid droplet association by core is connected to virus production... - Mobility analysis of an NS5A-GFP fusion protein in cells actively replicating hepatitis C virus subgenomic RNADaniel M Jones
MRC Virology Unit, Institute of Virology, Church Street, Glasgow G11 5JR, UK
J Gen Virol 88:470-5. 2007..Thus, the sites of HCV RNA replication possibly have a fixed complement of proteins that may act as discrete factories for producing viral RNA... - Live cell analysis and targeting of the lipid droplet-binding adipocyte differentiation-related proteinPaul Targett-Adams
MRC Virology Unit, Church Street, Glasgow G11 5JR, Scotland, United Kingdom
J Biol Chem 278:15998-6007. 2003..This system provides new insights into the properties of lipid droplets and their interaction with cellular processes... - Visualization of double-stranded RNA in cells supporting hepatitis C virus RNA replicationPaul Targett-Adams
MRC Virology Unit, Church Street, Glasgow G11 5JR, United Kingdom
J Virol 82:2182-95. 2008..Thus, we report the visualization of HCV-induced dsRNA foci, the likely sites of virus RNA replication, and propose that HCV genome synthesis occurs at LD-associated sites attached to the ER in virus-infected cells... - The herpes simplex virus type 1 DNA packaging protein UL17 is a virion protein that is present in both the capsid and the tegument compartmentsJohanna K Thurlow
MRC Virology Unit, Institute of Virology, Glasgow, United Kingdom
J Virol 79:150-8. 2005..UL6, the third virion-associated packaging protein, was present in slightly increased levels in L particles... - Transcriptional slippage prompts recoding in alternate reading frames in the hepatitis C virus (HCV) core sequence from strain HCV-1Maxime Ratinier
IBCP Institut de Biologie et Chimie des Protéines, CNRS, UMR 5086, Universite de Lyon, IFR 128, 7 passage du Vercors, F 69367 Lyon, France
J Gen Virol 89:1569-78. 2008..These findings have important implications for insight into frameshifting events in HCV-1 and demonstrate for the first time the involvement of transcriptional slippage in this recoding event... - Signal peptide peptidase cleavage of GB virus B core protein is required for productive infection in vivoPaul Targett-Adams
Medical Research Council Virology Unit, Church Street, Glasgow, G11 5JR, United Kingdom
J Biol Chem 281:29221-7. 2006..Moreover, they identify SPP as a potential therapeutic target for reducing the impact of HCV infection...