Paul Targett-Adams

Summary

Affiliation: University of Glasgow
Country: UK

Publications

  1. ncbi request reprint A PPAR response element regulates transcription of the gene for human adipose differentiation-related protein
    Paul Targett-Adams
    MRC Virology Unit, Institute of Virology, University of Glasgow, Church Street, Glasgow G11 5JR, UK
    Biochim Biophys Acta 1728:95-104. 2005
  2. ncbi request reprint Development and characterization of a transient-replication assay for the genotype 2a hepatitis C virus subgenomic replicon
    Paul Targett-Adams
    MRC Virology Unit, Institute of Virology, Church Street, Glasgow G11 5JR, UK
    J Gen Virol 86:3075-80. 2005
  3. doi request reprint Comparison of U2OS and Huh-7 cells for identifying host factors that affect hepatitis C virus RNA replication
    Daniel M Jones
    MRC Virology Unit, Church Street, Glasgow G11 5JR, UK
    J Gen Virol 91:2238-48. 2010
  4. ncbi request reprint Structural determinants that target the hepatitis C virus core protein to lipid droplets
    Steeve Boulant
    Medical Research Council Virology Unit, Institute of Virology, Church St, Glasgow G11 5JR, Scotland, United Kingdom
    J Biol Chem 281:22236-47. 2006
  5. pmc The hepatitis C virus NS4B protein can trans-complement viral RNA replication and modulates production of infectious virus
    Daniel M Jones
    MRC Virology Unit, Church Street, Glasgow G11 5JR, United Kingdom
    J Virol 83:2163-77. 2009
  6. doi request reprint Hepatitis C virus core protein induces lipid droplet redistribution in a microtubule- and dynein-dependent manner
    Steeve Boulant
    MRC Virology Unit, Institute of Virology, Church Street, Glasgow G11 5JR, UK
    Traffic 9:1268-82. 2008
  7. pmc Requirement of cellular DDX3 for hepatitis C virus replication is unrelated to its interaction with the viral core protein
    Allan G N Angus
    MRC Virology Unit, Institute of Virology, University of Glasgow, Church Street, Glasgow G11 5JR, UK
    J Gen Virol 91:122-32. 2010
  8. doi request reprint Maturation of hepatitis C virus core protein by signal peptide peptidase is required for virus production
    Paul Targett-Adams
    MRC Virology Unit, Institute of Virology, Glasgow G11 5JR, United Kingdom
    J Biol Chem 283:16850-9. 2008
  9. ncbi request reprint Disrupting the association of hepatitis C virus core protein with lipid droplets correlates with a loss in production of infectious virus
    Steeve Boulant
    MRC Virology Unit, Institute of Virology, Church Street, Glasgow G11 5JR, UK
    J Gen Virol 88:2204-13. 2007
  10. ncbi request reprint Mobility analysis of an NS5A-GFP fusion protein in cells actively replicating hepatitis C virus subgenomic RNA
    Daniel M Jones
    MRC Virology Unit, Institute of Virology, Church Street, Glasgow G11 5JR, UK
    J Gen Virol 88:470-5. 2007

Collaborators

Detail Information

Publications15

  1. ncbi request reprint A PPAR response element regulates transcription of the gene for human adipose differentiation-related protein
    Paul Targett-Adams
    MRC Virology Unit, Institute of Virology, University of Glasgow, Church Street, Glasgow G11 5JR, UK
    Biochim Biophys Acta 1728:95-104. 2005
    ..These findings offer insight into the mechanisms which serve to regulate ADRP transcription and intracellular lipid storage...
  2. ncbi request reprint Development and characterization of a transient-replication assay for the genotype 2a hepatitis C virus subgenomic replicon
    Paul Targett-Adams
    MRC Virology Unit, Institute of Virology, Church Street, Glasgow G11 5JR, UK
    J Gen Virol 86:3075-80. 2005
    ..Thus, this system based on JFH1 sequences offers improvements over prior genotype 1b replicons for quantitative measurement of viral RNA replication...
  3. doi request reprint Comparison of U2OS and Huh-7 cells for identifying host factors that affect hepatitis C virus RNA replication
    Daniel M Jones
    MRC Virology Unit, Church Street, Glasgow G11 5JR, UK
    J Gen Virol 91:2238-48. 2010
    ..Therefore, this study provides an important framework for future detailed analyses of these and other cellular proteins...
  4. ncbi request reprint Structural determinants that target the hepatitis C virus core protein to lipid droplets
    Steeve Boulant
    Medical Research Council Virology Unit, Institute of Virology, Church St, Glasgow G11 5JR, Scotland, United Kingdom
    J Biol Chem 281:22236-47. 2006
    ..They also serve as a unique model for elucidating the specificity of protein-lipid interactions between two membrane-bound organelles...
  5. pmc The hepatitis C virus NS4B protein can trans-complement viral RNA replication and modulates production of infectious virus
    Daniel M Jones
    MRC Virology Unit, Church Street, Glasgow G11 5JR, United Kingdom
    J Virol 83:2163-77. 2009
    ..Finally, one of the NS4B mutations increased the yield of infectious virus by five- to sixfold. Hence, NS4B not only functions in RNA replication but also contributes to the processes engaged in virus assembly and release...
  6. doi request reprint Hepatitis C virus core protein induces lipid droplet redistribution in a microtubule- and dynein-dependent manner
    Steeve Boulant
    MRC Virology Unit, Institute of Virology, Church Street, Glasgow G11 5JR, UK
    Traffic 9:1268-82. 2008
    ..We propose that the presence of core on LDs favours their movement towards the nucleus, possibly to increase the probability of interaction between sites of HCV RNA replication and virion assembly...
  7. pmc Requirement of cellular DDX3 for hepatitis C virus replication is unrelated to its interaction with the viral core protein
    Allan G N Angus
    MRC Virology Unit, Institute of Virology, University of Glasgow, Church Street, Glasgow G11 5JR, UK
    J Gen Virol 91:122-32. 2010
    ..Thus, our study shows for the first time that the requirement of DDX3 for HCV replication is unrelated to its interaction with the viral core protein...
  8. doi request reprint Maturation of hepatitis C virus core protein by signal peptide peptidase is required for virus production
    Paul Targett-Adams
    MRC Virology Unit, Institute of Virology, Glasgow G11 5JR, United Kingdom
    J Biol Chem 283:16850-9. 2008
    ..Moreover, they offer compelling evidence for a function for an intramembrane protease to facilitate the association of core with viral genomes, thereby creating putative sites for assembly of nascent virus particles...
  9. ncbi request reprint Disrupting the association of hepatitis C virus core protein with lipid droplets correlates with a loss in production of infectious virus
    Steeve Boulant
    MRC Virology Unit, Institute of Virology, Church Street, Glasgow G11 5JR, UK
    J Gen Virol 88:2204-13. 2007
    ..Taken together, our findings indicate that lipid droplet association by core is connected to virus production...
  10. ncbi request reprint Mobility analysis of an NS5A-GFP fusion protein in cells actively replicating hepatitis C virus subgenomic RNA
    Daniel M Jones
    MRC Virology Unit, Institute of Virology, Church Street, Glasgow G11 5JR, UK
    J Gen Virol 88:470-5. 2007
    ..Thus, the sites of HCV RNA replication possibly have a fixed complement of proteins that may act as discrete factories for producing viral RNA...
  11. ncbi request reprint Live cell analysis and targeting of the lipid droplet-binding adipocyte differentiation-related protein
    Paul Targett-Adams
    MRC Virology Unit, Church Street, Glasgow G11 5JR, Scotland, United Kingdom
    J Biol Chem 278:15998-6007. 2003
    ..This system provides new insights into the properties of lipid droplets and their interaction with cellular processes...
  12. pmc Visualization of double-stranded RNA in cells supporting hepatitis C virus RNA replication
    Paul Targett-Adams
    MRC Virology Unit, Church Street, Glasgow G11 5JR, United Kingdom
    J Virol 82:2182-95. 2008
    ..Thus, we report the visualization of HCV-induced dsRNA foci, the likely sites of virus RNA replication, and propose that HCV genome synthesis occurs at LD-associated sites attached to the ER in virus-infected cells...
  13. pmc The herpes simplex virus type 1 DNA packaging protein UL17 is a virion protein that is present in both the capsid and the tegument compartments
    Johanna K Thurlow
    MRC Virology Unit, Institute of Virology, Glasgow, United Kingdom
    J Virol 79:150-8. 2005
    ..UL6, the third virion-associated packaging protein, was present in slightly increased levels in L particles...
  14. doi request reprint Transcriptional slippage prompts recoding in alternate reading frames in the hepatitis C virus (HCV) core sequence from strain HCV-1
    Maxime Ratinier
    IBCP Institut de Biologie et Chimie des Protéines, CNRS, UMR 5086, Universite de Lyon, IFR 128, 7 passage du Vercors, F 69367 Lyon, France
    J Gen Virol 89:1569-78. 2008
    ..These findings have important implications for insight into frameshifting events in HCV-1 and demonstrate for the first time the involvement of transcriptional slippage in this recoding event...
  15. ncbi request reprint Signal peptide peptidase cleavage of GB virus B core protein is required for productive infection in vivo
    Paul Targett-Adams
    Medical Research Council Virology Unit, Church Street, Glasgow, G11 5JR, United Kingdom
    J Biol Chem 281:29221-7. 2006
    ..Moreover, they identify SPP as a potential therapeutic target for reducing the impact of HCV infection...