Peter S Talbot

Summary

Affiliation: University of Manchester
Country: UK

Publications

  1. pmc Brain serotonin transporter occupancy by oral sibutramine dosed to steady state: a PET study using (11)C-DASB in healthy humans
    Peter S Talbot
    Wolfson Molecular Imaging Centre, The University of Manchester, Manchester, UK
    Neuropsychopharmacology 35:741-51. 2010
  2. ncbi request reprint Anterior cingulate and subgenual prefrontal blood flow changes following tryptophan depletion in healthy males
    Peter S Talbot
    Division of Psychiatry and Neuroscience, Queen s University Belfast, Northern Ireland, UK
    Neuropsychopharmacology 31:1757-67. 2006
  3. ncbi request reprint Rapid tryptophan depletion improves decision-making cognition in healthy humans without affecting reversal learning or set shifting
    Peter S Talbot
    Division of Psychiatry and Neuroscience, Queen s University Belfast, Northern Ireland, UK
    Neuropsychopharmacology 31:1519-25. 2006
  4. pmc Extended characterisation of the serotonin 2A (5-HT2A) receptor-selective PET radiotracer 11C-MDL100907 in humans: quantitative analysis, test-retest reproducibility, and vulnerability to endogenous 5-HT tone
    Peter S Talbot
    Department of Psychiatry, Columbia University College of Physicians and Surgeons and the New York State Psychiatric Institute, New York, NY 10032, USA
    Neuroimage 59:271-85. 2012
  5. ncbi request reprint Effects of reduced endogenous 5-HT on the in vivo binding of the serotonin transporter radioligand 11C-DASB in healthy humans
    Peter S Talbot
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York State Psychiatric Institute, New York, New York 10032, USA
    Synapse 55:164-75. 2005
  6. ncbi request reprint Brain serotonin transporter distribution in subjects with impulsive aggressivity: a positron emission study with [11C]McN 5652
    W Gordon Frankle
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, and the New York State Psychiatric Institute, 1051 Riverside Dr, Box 31, New York, NY 10032, USA
    Am J Psychiatry 162:915-23. 2005
  7. ncbi request reprint In vivo vulnerability to competition by endogenous dopamine: comparison of the D2 receptor agonist radiotracer (-)-N-[11C]propyl-norapomorphine ([11C]NPA) with the D2 receptor antagonist radiotracer [11C]-raclopride
    Rajesh Narendran
    Department of Psychiatry, Columbia University College of Physicians and Surgeons and the New York State Psychiatric Institute, New York, NY 10032, USA
    Synapse 52:188-208. 2004
  8. ncbi request reprint 11C-GR103545, a radiotracer for imaging kappa-opioid receptors in vivo with PET: synthesis and evaluation in baboons
    Peter S Talbot
    Department of Psychiatry, Columbia University College of Physicians and Surgeons and the New York State Psychiatric Institute, New York, NY 10032, USA
    J Nucl Med 46:484-94. 2005
  9. ncbi request reprint Altered prefrontal dopaminergic function in chronic recreational ketamine users
    Rajesh Narendran
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Am J Psychiatry 162:2352-9. 2005
  10. doi request reprint Pre- and postsynaptic serotonergic differences in males with extreme levels of impulsive aggression without callous unemotional traits: a positron emission tomography study using (11)C-DASB and (11)C-MDL100907
    Angela J Rylands
    Mental Health and Neurodegeneration Research Group, Wolfson Molecular Imaging Centre, University of Manchester, Manchester, UK
    Biol Psychiatry 72:1004-11. 2012

Collaborators

Detail Information

Publications16

  1. pmc Brain serotonin transporter occupancy by oral sibutramine dosed to steady state: a PET study using (11)C-DASB in healthy humans
    Peter S Talbot
    Wolfson Molecular Imaging Centre, The University of Manchester, Manchester, UK
    Neuropsychopharmacology 35:741-51. 2010
    ..5-HT reuptake inhibition may be necessary but is not sufficient for sibutramine's efficacy in humans, supporting preclinical data suggesting that the hypophagic effect requires the co-inhibition of both SERT and NET...
  2. ncbi request reprint Anterior cingulate and subgenual prefrontal blood flow changes following tryptophan depletion in healthy males
    Peter S Talbot
    Division of Psychiatry and Neuroscience, Queen s University Belfast, Northern Ireland, UK
    Neuropsychopharmacology 31:1757-67. 2006
    ..The results therefore suggest that the dissociation between affective and cognitive consequences of RTD may possibly be attributable to differential effects of reduced 5-HT on these neural systems...
  3. ncbi request reprint Rapid tryptophan depletion improves decision-making cognition in healthy humans without affecting reversal learning or set shifting
    Peter S Talbot
    Division of Psychiatry and Neuroscience, Queen s University Belfast, Northern Ireland, UK
    Neuropsychopharmacology 31:1519-25. 2006
    ....
  4. pmc Extended characterisation of the serotonin 2A (5-HT2A) receptor-selective PET radiotracer 11C-MDL100907 in humans: quantitative analysis, test-retest reproducibility, and vulnerability to endogenous 5-HT tone
    Peter S Talbot
    Department of Psychiatry, Columbia University College of Physicians and Surgeons and the New York State Psychiatric Institute, New York, NY 10032, USA
    Neuroimage 59:271-85. 2012
    ..We present an extended characterisation in healthy human subjects...
  5. ncbi request reprint Effects of reduced endogenous 5-HT on the in vivo binding of the serotonin transporter radioligand 11C-DASB in healthy humans
    Peter S Talbot
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York State Psychiatric Institute, New York, New York 10032, USA
    Synapse 55:164-75. 2005
    ..These results suggest that (11)C-DASB in vivo binding is not affected by reductions in endogenous 5-HT...
  6. ncbi request reprint Brain serotonin transporter distribution in subjects with impulsive aggressivity: a positron emission study with [11C]McN 5652
    W Gordon Frankle
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, and the New York State Psychiatric Institute, 1051 Riverside Dr, Box 31, New York, NY 10032, USA
    Am J Psychiatry 162:915-23. 2005
    ..This study evaluated regional serotonin transporter distribution in the brain of individuals with impulsive aggression by using positron emission tomography (PET) with the serotonin transporter PET radiotracer [(11)C]McN 5652...
  7. ncbi request reprint In vivo vulnerability to competition by endogenous dopamine: comparison of the D2 receptor agonist radiotracer (-)-N-[11C]propyl-norapomorphine ([11C]NPA) with the D2 receptor antagonist radiotracer [11C]-raclopride
    Rajesh Narendran
    Department of Psychiatry, Columbia University College of Physicians and Surgeons and the New York State Psychiatric Institute, New York, NY 10032, USA
    Synapse 52:188-208. 2004
    ..In conclusion, [11C]NPA might provide a superior radiotracer to probe presynaptic DA function with PET in health and disease...
  8. ncbi request reprint 11C-GR103545, a radiotracer for imaging kappa-opioid receptors in vivo with PET: synthesis and evaluation in baboons
    Peter S Talbot
    Department of Psychiatry, Columbia University College of Physicians and Surgeons and the New York State Psychiatric Institute, New York, NY 10032, USA
    J Nucl Med 46:484-94. 2005
    ..The (-)-isomer, GR103545, is the active enantiomer of GR89696. The aim of this study was to characterize the potential of 11C-GR103545 to image kappa-OR in vivo with PET...
  9. ncbi request reprint Altered prefrontal dopaminergic function in chronic recreational ketamine users
    Rajesh Narendran
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Am J Psychiatry 162:2352-9. 2005
    ..In this study, dopamine D1 receptor availability was assessed by using positron emission tomography and the selective D1 receptor radioligand [11C]NNC 112 in a group of 14 recreational chronic ketamine users and matched healthy subjects...
  10. doi request reprint Pre- and postsynaptic serotonergic differences in males with extreme levels of impulsive aggression without callous unemotional traits: a positron emission tomography study using (11)C-DASB and (11)C-MDL100907
    Angela J Rylands
    Mental Health and Neurodegeneration Research Group, Wolfson Molecular Imaging Centre, University of Manchester, Manchester, UK
    Biol Psychiatry 72:1004-11. 2012
    ..We aimed to investigate 5-HT abnormalities in IA and potential correlations with severity of childhood adversity while controlling for confounding 5-HT effects of high CU traits and mental disorders...
  11. pmc Sustained recreational use of ecstasy is associated with altered pre and postsynaptic markers of serotonin transmission in neocortical areas: a PET study with [¹¹C]DASB and [¹¹C]MDL 100907
    Nina Bl Urban
    Department of Psychiatry, Columbia University, New York State Psychiatric Institute, New York, NY 10032, USA
    Neuropsychopharmacology 37:1465-73. 2012
    ..Alterations in mood, cognition, and impulse control associated with these changes might contribute to sustain MDMA use. The reversibility of these changes upon abstinence remains to be firmly established...
  12. ncbi request reprint Effect of amphetamine on [(18)F]fallypride in vivo binding to D(2) receptors in striatal and extrastriatal regions of the primate brain: Single bolus and bolus plus constant infusion studies
    Mark Slifstein
    Department of Psychiatry, Columbia University College of Physicians and Surgeons and the New York State Psychiatric Institute, New York, New York 10032, USA
    Synapse 54:46-63. 2004
    ....
  13. ncbi request reprint Comparative evaluation of serotonin transporter radioligands 11C-DASB and 11C-McN 5652 in healthy humans
    W Gordon Frankle
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, and the New York State Psychiatric Institute, New York, New York, USA
    J Nucl Med 45:682-94. 2004
    ..The purpose of this study was to compare these 2 agents in healthy humans...
  14. ncbi request reprint Neuroreceptor imaging in psychiatry: theory and applications
    W Gordon Frankle
    Departments of Psychiatry, Columbia University College of Physicians and Surgeons and New York State Psychiatric Institute, New York, New York 10032, USA
    Int Rev Neurobiol 67:385-440. 2005
  15. ncbi request reprint Quantitative analysis of (-)-N-(11)C-propyl-norapomorphine in vivo binding in nonhuman primates
    Dah Ren Hwang
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY, USA
    J Nucl Med 45:338-46. 2004
    ..The goal of this study was to develop and evaluate analytic strategies to derive in vivo (11)C-NPA binding parameters...
  16. ncbi request reprint The molecular neuroimaging of anxiety disorders
    Peter S Talbot
    Division of Functional Brain Mapping, New York State Psychiatric Institute, 1051 Riverside Drive, Unit 31, New York, NY 10032, USA
    Curr Psychiatry Rep 6:274-9. 2004
    ..Recent findings have extended the knowledge of hippocampal abnormalities in post-traumatic stress disorder, and have highlighted the complexity of the association between cortisol and the hippocampus in this disorder...