Lydia Tabernero

Summary

Affiliation: University of Manchester
Country: UK

Publications

  1. ncbi request reprint Characterization of an HMG-CoA reductase from Listeria monocytogenes that exhibits dual coenzyme specificity
    Amy E Theivagt
    Department of Chemistry, Illinois State University, Normal, Illinois 61790, USA
    Biochemistry 45:14397-406. 2006
  2. pmc Protein tyrosine phosphatase TbPTP1: A molecular switch controlling life cycle differentiation in trypanosomes
    Balazs Szoor
    Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh EH9 3JT, Scotland, UK
    J Cell Biol 175:293-303. 2006
  3. ncbi request reprint Crystal structure of a statin bound to a class II hydroxymethylglutaryl-CoA reductase
    Lydia Tabernero
    School of Biological Sciences, University of Manchester, Oxford Road, United Kingdom
    J Biol Chem 278:19933-8. 2003
  4. doi request reprint Biophysical and X-ray crystallographic analysis of Mps1 kinase inhibitor complexes
    Matthew L H Chu
    Wolfson Centre for Structure Based Rational Design of Molecular Diagnostics, School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Manchester M13 9PL, UK
    Biochemistry 49:1689-701. 2010
  5. pmc A new family of phosphoinositide phosphatases in microorganisms: identification and biochemical analysis
    Nicola J Beresford
    Faculty of Life Sciences, Michael Smith Building, University of Manchester, Manchester M13 9PT, UK
    BMC Genomics 11:457. 2010
  6. pmc The TriTryp phosphatome: analysis of the protein phosphatase catalytic domains
    Rachel Brenchley
    Faculty of Life Sciences, Michael Smith, University of Manchester, M13 9PT, UK
    BMC Genomics 8:434. 2007
  7. doi request reprint Crystal structure of the catalytic domain of the mitotic checkpoint kinase Mps1 in complex with SP600125
    Matthew L H Chu
    School of Pharmacy and Pharmaceutical Sciences, Stopford Building, University of Manchester, Manchester, UK
    J Biol Chem 283:21495-500. 2008
  8. doi request reprint Inhibition of MptpB phosphatase from Mycobacterium tuberculosis impairs mycobacterial survival in macrophages
    Nicola J Beresford
    University of Manchester, UK
    J Antimicrob Chemother 63:928-36. 2009
  9. ncbi request reprint Functional assignment of MAPK phosphatase domains
    Anna K L Nordle
    Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom
    Proteins 69:19-31. 2007
  10. doi request reprint New strategies in fighting TB: targeting Mycobacterium tuberculosis-secreted phosphatases MptpA & MptpB
    Ana P G Silva
    Faculty of Life Sciences, University of Manchester, Michael Smith Building, Oxford Road, Manchester, M13 9PT, UK
    Future Med Chem 2:1325-37. 2010

Collaborators

Detail Information

Publications12

  1. ncbi request reprint Characterization of an HMG-CoA reductase from Listeria monocytogenes that exhibits dual coenzyme specificity
    Amy E Theivagt
    Department of Chemistry, Illinois State University, Normal, Illinois 61790, USA
    Biochemistry 45:14397-406. 2006
    ....
  2. pmc Protein tyrosine phosphatase TbPTP1: A molecular switch controlling life cycle differentiation in trypanosomes
    Balazs Szoor
    Institute of Immunology and Infection Research, University of Edinburgh, Edinburgh EH9 3JT, Scotland, UK
    J Cell Biol 175:293-303. 2006
    ..It may be possible to use PTP1B inhibitors to block trypanosomatid transmission...
  3. ncbi request reprint Crystal structure of a statin bound to a class II hydroxymethylglutaryl-CoA reductase
    Lydia Tabernero
    School of Biological Sciences, University of Manchester, Oxford Road, United Kingdom
    J Biol Chem 278:19933-8. 2003
    ..We suggest that these differences might be exploited to develop selective class II inhibitors for use as antibacterial agents against pathogenic microorganisms...
  4. doi request reprint Biophysical and X-ray crystallographic analysis of Mps1 kinase inhibitor complexes
    Matthew L H Chu
    Wolfson Centre for Structure Based Rational Design of Molecular Diagnostics, School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Manchester M13 9PL, UK
    Biochemistry 49:1689-701. 2010
    ....
  5. pmc A new family of phosphoinositide phosphatases in microorganisms: identification and biochemical analysis
    Nicola J Beresford
    Faculty of Life Sciences, Michael Smith Building, University of Manchester, Manchester M13 9PT, UK
    BMC Genomics 11:457. 2010
    ..We used this P-loop signature as a "diagnostic motif" to identify related putative phosphatases with phosphoinositide activity in other organisms...
  6. pmc The TriTryp phosphatome: analysis of the protein phosphatase catalytic domains
    Rachel Brenchley
    Faculty of Life Sciences, Michael Smith, University of Manchester, M13 9PT, UK
    BMC Genomics 8:434. 2007
    ..With the aim to further our knowledge of the biology of these organisms we present a characterisation of the phosphatase complement (phosphatome) of the three parasites...
  7. doi request reprint Crystal structure of the catalytic domain of the mitotic checkpoint kinase Mps1 in complex with SP600125
    Matthew L H Chu
    School of Pharmacy and Pharmaceutical Sciences, Stopford Building, University of Manchester, Manchester, UK
    J Biol Chem 283:21495-500. 2008
    ..These structures provide important insights into the interaction of this protein kinase with small molecules and suggest potential mechanisms for Mps1 regulation...
  8. doi request reprint Inhibition of MptpB phosphatase from Mycobacterium tuberculosis impairs mycobacterial survival in macrophages
    Nicola J Beresford
    University of Manchester, UK
    J Antimicrob Chemother 63:928-36. 2009
    ..tuberculosis and contributes to its survival within host macrophages. The aim of this study was to identify potent selective inhibitors of MptpB and to determine the efficacy of these compounds in mycobacterium-infected macrophages...
  9. ncbi request reprint Functional assignment of MAPK phosphatase domains
    Anna K L Nordle
    Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom
    Proteins 69:19-31. 2007
    ..These results also suggest the presence of putative allosteric sites in the catalytic region for modulation of protein-protein interactions, and provide a framework for future experimental validation...
  10. doi request reprint New strategies in fighting TB: targeting Mycobacterium tuberculosis-secreted phosphatases MptpA & MptpB
    Ana P G Silva
    Faculty of Life Sciences, University of Manchester, Michael Smith Building, Oxford Road, Manchester, M13 9PT, UK
    Future Med Chem 2:1325-37. 2010
    ..We describe the recent efforts in developing specific, selective and cell-active inhibitors of MptpA and MptpB, and discuss their potential applications as alternative treatments of TB...
  11. pmc MptpB, a virulence factor from Mycobacterium tuberculosis, exhibits triple-specificity phosphatase activity
    Nicola Beresford
    Faculty of Life Sciences, Michael Smith Building, University of Manchester, Manchester M13 9PT, UK
    Biochem J 406:13-8. 2007
    ....
  12. ncbi request reprint ERK2 shows a restrictive and locally selective mechanism of recognition by its tyrosine phosphatase inactivators not shared by its activator MEK1
    Céline Tárrega
    Centro de Investigacion Principe Felipe, Valencia, Spain
    J Biol Chem 280:37885-94. 2005
    ....