Affiliation: University of Manchester
- Characterization of an HMG-CoA reductase from Listeria monocytogenes that exhibits dual coenzyme specificityAmy E Theivagt
Department of Chemistry, Illinois State University, Normal, Illinois 61790, USA
Biochemistry 45:14397-406. 2006....
- Crystal structure of a statin bound to a class II hydroxymethylglutaryl-CoA reductaseLydia Tabernero
School of Biological Sciences, University of Manchester, Oxford Road, United Kingdom
J Biol Chem 278:19933-8. 2003..We suggest that these differences might be exploited to develop selective class II inhibitors for use as antibacterial agents against pathogenic microorganisms...
- ERK2 shows a restrictive and locally selective mechanism of recognition by its tyrosine phosphatase inactivators not shared by its activator MEK1Céline Tárrega
Centro de Investigacion Principe Felipe, Valencia, Spain
J Biol Chem 280:37885-94. 2005....
- Crystal structure of the catalytic domain of the mitotic checkpoint kinase Mps1 in complex with SP600125Matthew L H Chu
School of Pharmacy and Pharmaceutical Sciences, Stopford Building, University of Manchester, Manchester, UK
J Biol Chem 283:21495-500. 2008..These structures provide important insights into the interaction of this protein kinase with small molecules and suggest potential mechanisms for Mps1 regulation...