M E Symonds

Summary

Affiliation: University of Nottingham
Country: UK

Publications

  1. pmc Brown adipose tissue and seasonal variation in humans
    Iain T H Au-Yong
    Departments of Radiology and Nuclear Medicine, Queens Medical Centre, University Hospitals, Nottingham, U K
    Diabetes 58:2583-7. 2009
  2. pmc Maternal parity and its effect on adipose tissue deposition and endocrine sensitivity in the postnatal sheep
    M A Hyatt
    Early Life Nutrition Research Unit, Division of Human Development, Academic Child Health, School of Clinical Sciences, University Hospital, University of Nottingham, Nottingham NG7 2UH, UK
    J Endocrinol 204:173-9. 2010
  3. pmc Suboptimal maternal nutrition, during early fetal liver development, promotes lipid accumulation in the liver of obese offspring
    M A Hyatt
    Early Life Nutrition Research Unit, Academic Child Health Respiratory Biomedical Research Unit, School of Clinical Sciences, Queen s Medical Centre, University Hospital, Nottingham, UK
    Reproduction 141:119-26. 2011
  4. pmc Maternal nutrient restriction during late gestation and early postnatal growth in sheep differentially reset the control of energy metabolism in the gastric mucosa
    S P Sebert
    Academic Child Health, School of Clinical Sciences, University Hospital, University of Nottingham, Nottingham, NG7 2UH United Kingdom
    Endocrinology 152:2816-26. 2011
  5. pmc The obesity epidemic: from the environment to epigenetics - not simply a response to dietary manipulation in a thermoneutral environment
    Michael E Symonds
    Early Life Nutrition Research Unit, Academic Division of Child Health, Nottingham Respiratory Medicine Biomedical Research Unit, School of Clinical Sciences, University Hospital Nottingham, UK
    Front Genet 2:24. 2011
  6. doi request reprint Sex differences in metabolic and adipose tissue responses to juvenile-onset obesity in sheep
    Ian D Bloor
    Academic Division of Child Health School of Clinical Sciences, E Floor, East Block, Queen s Medical Centre, University Hospital, The University of Nottingham, Nottingham NG7 2UH, United Kingdom
    Endocrinology 154:3622-31. 2013
  7. doi request reprint Thermal imaging to assess age-related changes of skin temperature within the supraclavicular region co-locating with brown adipose tissue in healthy children
    Michael E Symonds
    The Early Life Nutrition Research Unit, Academic Division of Child Health, School of Clinical Sciences, University Hospital, Nottingham, United Kingdom
    J Pediatr 161:892-8. 2012
  8. doi request reprint The influence of sex on early stage markers of kidney dysfunction in response to juvenile obesity
    Ian D Bloor
    Early Life Nutrition Research Unit, Academic Division of Child Health, School of Medicine, E Floor, East Block, Queen s Medical Centre, University Hospital, Nottingham, United Kingdom
    Hypertension 60:991-7. 2012
  9. doi request reprint Adipose tissue development during early life: novel insights into energy balance from small and large mammals
    Michael E Symonds
    The Early Life Nutrition Research Unit, Academic Child Health, School of Clinical Sciences, University Hospital, Nottingham NG7 2UH, UK
    Proc Nutr Soc 71:363-70. 2012
  10. doi request reprint Adipose tissue and fetal programming
    M E Symonds
    The Early Life Nutrition Research Unit, Academic Division of Child Health, School of Clinical Sciences, University Hospital, Nottingham, NG7 2UH, UK
    Diabetologia 55:1597-606. 2012

Collaborators

Detail Information

Publications95

  1. pmc Brown adipose tissue and seasonal variation in humans
    Iain T H Au-Yong
    Departments of Radiology and Nuclear Medicine, Queens Medical Centre, University Hospitals, Nottingham, U K
    Diabetes 58:2583-7. 2009
    ..The objective of our study was therefore to determine whether seasonal variation in BAT activity in humans was more closely related to the prevailing photoperiod or temperature...
  2. pmc Maternal parity and its effect on adipose tissue deposition and endocrine sensitivity in the postnatal sheep
    M A Hyatt
    Early Life Nutrition Research Unit, Division of Human Development, Academic Child Health, School of Clinical Sciences, University Hospital, University of Nottingham, Nottingham NG7 2UH, UK
    J Endocrinol 204:173-9. 2010
    ..Our findings emphasise the importance of parity in determining adipose tissue development and that firstborn offspring have an increased capacity for adipogenesis which may be critical in determining later adiposity...
  3. pmc Suboptimal maternal nutrition, during early fetal liver development, promotes lipid accumulation in the liver of obese offspring
    M A Hyatt
    Early Life Nutrition Research Unit, Academic Child Health Respiratory Biomedical Research Unit, School of Clinical Sciences, Queen s Medical Centre, University Hospital, Nottingham, UK
    Reproduction 141:119-26. 2011
    ..In conclusion, excess hepatic lipid accumulation with juvenile obesity is promoted by suboptimal nutrition coincident with early development of the fetal liver...
  4. pmc Maternal nutrient restriction during late gestation and early postnatal growth in sheep differentially reset the control of energy metabolism in the gastric mucosa
    S P Sebert
    Academic Child Health, School of Clinical Sciences, University Hospital, University of Nottingham, Nottingham, NG7 2UH United Kingdom
    Endocrinology 152:2816-26. 2011
    ....
  5. pmc The obesity epidemic: from the environment to epigenetics - not simply a response to dietary manipulation in a thermoneutral environment
    Michael E Symonds
    Early Life Nutrition Research Unit, Academic Division of Child Health, Nottingham Respiratory Medicine Biomedical Research Unit, School of Clinical Sciences, University Hospital Nottingham, UK
    Front Genet 2:24. 2011
    ..The potential to utilize novel models and interventions across a range of animal species in adipose tissue development may finally start to yield sustainable strategies by which excess fat mass can, at last, be avoided in humans...
  6. doi request reprint Sex differences in metabolic and adipose tissue responses to juvenile-onset obesity in sheep
    Ian D Bloor
    Academic Division of Child Health School of Clinical Sciences, E Floor, East Block, Queen s Medical Centre, University Hospital, The University of Nottingham, Nottingham NG7 2UH, United Kingdom
    Endocrinology 154:3622-31. 2013
    ..These sex-specific differences in cortisol and adipose tissue could explain the earlier onset of the metabolic-related diseases in males compared with females after obesity. ..
  7. doi request reprint Thermal imaging to assess age-related changes of skin temperature within the supraclavicular region co-locating with brown adipose tissue in healthy children
    Michael E Symonds
    The Early Life Nutrition Research Unit, Academic Division of Child Health, School of Clinical Sciences, University Hospital, Nottingham, United Kingdom
    J Pediatr 161:892-8. 2012
    ..To establish the feasibility of infrared thermal imaging as a reproducible, noninvasive method for assessing changes in skin temperature within the supraclavicular region in vivo...
  8. doi request reprint The influence of sex on early stage markers of kidney dysfunction in response to juvenile obesity
    Ian D Bloor
    Early Life Nutrition Research Unit, Academic Division of Child Health, School of Medicine, E Floor, East Block, Queen s Medical Centre, University Hospital, Nottingham, United Kingdom
    Hypertension 60:991-7. 2012
    ..An increased understanding of the specific mechanisms will have important implications for therapeutic strategies aimed at preventing adverse consequences of obesity...
  9. doi request reprint Adipose tissue development during early life: novel insights into energy balance from small and large mammals
    Michael E Symonds
    The Early Life Nutrition Research Unit, Academic Child Health, School of Clinical Sciences, University Hospital, Nottingham NG7 2UH, UK
    Proc Nutr Soc 71:363-70. 2012
    ..Such interventions could modify, or reverse, the normal ontogenic pathway by which BAT disappears after birth, thereby facilitating BAT thermogenesis through the life cycle...
  10. doi request reprint Adipose tissue and fetal programming
    M E Symonds
    The Early Life Nutrition Research Unit, Academic Division of Child Health, School of Clinical Sciences, University Hospital, Nottingham, NG7 2UH, UK
    Diabetologia 55:1597-606. 2012
    ..In conclusion, the growth of the different fetal adipose tissue depots varies according to maternal diet and, if challenged in later life, this can contribute to insulin resistance and impaired glucose homeostasis...
  11. ncbi request reprint Fetal endocrinology and development--manipulation and adaptation to long-term nutritional and environmental challenges
    M E Symonds
    Academic Division of Child Health, School of Human Development, University Hospital, Nottingham NG7 2UH, UK
    Reproduction 121:853-62. 2001
    ..This nutritional manipulation replicates, in part, epidemiological findings from the Dutch famine of 1944-1945, for which the offspring are at increased risk of adult obesity...
  12. doi request reprint Adipose tissue development--impact of the early life environment
    Michael E Symonds
    Early Life Nutrition Research Unit, Academic Child Health, School of Clinical Sciences, University Hospital, Nottingham NG72UH, United Kingdom
    Prog Biophys Mol Biol 106:300-6. 2011
    ....
  13. ncbi request reprint The influence of acute hypoxia and carotid body denervation on thermoregulation during non-rapid eye movement sleep in the developing lamb
    M E Symonds
    Academic Division of Child Health, School of Human Development, University Hospital, Queen s Medical Centre, Nottingham, NG7 2UH, UK
    Exp Physiol 84:1115-26. 1999
    ..Compromised carotid body function, in lambs older than 2 weeks of age, can result in severe hypoxia and thermoregulatory dysfunction even with modest environmental cooling...
  14. ncbi request reprint Timing of nutrient restriction and programming of fetal adipose tissue development
    Michael E Symonds
    Centre for Reproduction and Early Life, Institute of Clinical Research, Queen s Medical Centre, University Hospital, Nottingham NG7 2UH, UK
    Proc Nutr Soc 63:397-403. 2004
    ..Increasing maternal nutrition in late gestation, however, can result in proportionately less fetal adipose tissue deposition in conjunction with enhanced abundance of uncoupling protein 1...
  15. ncbi request reprint Nutritional programming of the metabolic syndrome
    Michael E Symonds
    Early Life Nutrition Research Unit, Academic Child Health, Division of Human Development, School of Clinical Sciences, University Hospital, Nottingham, UK
    Nat Rev Endocrinol 5:604-10. 2009
    ....
  16. ncbi request reprint Influence of maternal bodyweight on adaptation after birth in near-term lambs delivered by Caesarean section
    M E Symonds
    Academic Division of Child Health, School of Human Development, University Hospital, Queen s Medical Centre, Nottingham, UK
    Reprod Fertil Dev 10:333-9. 1998
    ..In conclusion, maternal bodyweight has a critical influence on survival following caesarean section birth that is dependent on the ambient temperature into which a lamb is delivered...
  17. doi request reprint Tissue specific adaptations to nutrient supply: more than just epigenetics?
    Michael E Symonds
    Centre for Reproduction and Early Life, Institute of Clinical Research, University Hospital, Nottingham, UK
    Adv Exp Med Biol 646:113-8. 2009
    ..Such adaptations do not simply represent epigenetic modifications but a plethora of responses that, taken together, can prevent, or delay, at least in the kidney, the onset of apoptosis and later glomerulosclerosis...
  18. doi request reprint The impact of diet during early life and its contribution to later disease: critical checkpoints in development and their long-term consequences for metabolic health
    Michael E Symonds
    Early Life Nutrition Research Unit, Academic Child Health, Division of Human Development, and Nottingham Respiratory Medicine Biomedical Research Unit, School of Clinical Sciences, Queen s Medical Centre, University Hospitals, Nottingham NG7 2UH, UK
    Proc Nutr Soc 68:416-21. 2009
    ....
  19. ncbi request reprint Leptin, fetal nutrition, and long-term outcomes for adult hypertension
    Michael E Symonds
    Centre for Reproduction and Early Life, Institute of Clinical Research, University Hospital, Nottingham, United Kingdom
    Endothelium 12:73-9. 2005
    ....
  20. ncbi request reprint Effect of delivery temperature on endocrine stimulation of thermoregulation in lambs born by cesarean section
    M E Symonds
    Academic Division of Child Health, School of Human Development, University Hospital, Queen s Medical Centre, Nottingham NG7 2UH, United Kingdom
    J Appl Physiol (1985) 88:47-53. 2000
    ..Exogenous administration of endocrine stimulatory factors can enhance the abundance of UCP1 in cesarean-section-delivered lambs with the magnitude of thermoregulatory response being greater at cool than warm delivery temperatures...
  21. doi request reprint Conference on "Multidisciplinary approaches to nutritional problems". Symposium on "Diabetes and health". Nutrition and its contribution to obesity and diabetes: a life-course approach to disease prevention?
    Michael E Symonds
    Centre for Reproduction and Early Life, Institute of Clinical Research, University of Nottingham, NG72UH, UK
    Proc Nutr Soc 68:71-7. 2009
    ....
  22. ncbi request reprint Long-term effects of nutritional programming of the embryo and fetus: mechanisms and critical windows
    Michael E Symonds
    Centre for Reproduction and Early Life, Institute of Clinical Research, University Hospital, Nottingham, NG7 2UH, UK
    Reprod Fertil Dev 19:53-63. 2007
    ..Increased or decreased maternal plasma glucose alone, or in conjunction with other macro- or micronutrients, may result in offspring at increased risk of adult diseases...
  23. doi request reprint Nutritional models of the developmental programming of adult health and disease
    Michael E Symonds
    Centre for Reproduction and Early Life, Institute of Clinical Research, University Hospital, Nottingham, UK
    Proc Nutr Soc 68:173-8. 2009
    ....
  24. ncbi request reprint Experimental evidence for early nutritional programming of later health in animals
    Michael E Symonds
    Centre for Reproduction and Early Life, Institute of Clinical Research, University of Nottingham, UK
    Curr Opin Clin Nutr Metab Care 9:278-83. 2006
    ..In this review, some of the most important recent publications will be highlighted, particularly those focusing on the consequences for later cardiovascular control and obesity...
  25. doi request reprint Early determinants of cardiovascular disease: the role of early diet in later blood pressure control
    Michael E Symonds
    Centre for Reproduction and Early Life, The Institute of Clinical Research, The University of Nottingham, Nottingham, United Kingdom
    Am J Clin Nutr 89:1518S-1522S. 2009
    ..One clear priority is the prevention of excess adiposity and to determine how epigenetic mechanisms may provide novel strategies in this regard...
  26. ncbi request reprint Maternal nutrient restriction during placental growth, programming of fetal adiposity and juvenile blood pressure control
    M E Symonds
    School of Human Development, University Hospital, Nottingham, UK
    Arch Physiol Biochem 111:45-52. 2003
    ..Reduced maternal nutrition during the period of rapid placental growth may therefore contribute to hypertension in later life through physiological and vascular adaptations during fetal life...
  27. ncbi request reprint Integration of physiological and molecular mechanisms of the developmental origins of adult disease: new concepts and insights
    Michael E Symonds
    Centre for Reproduction and Early Life, Institute of Clinical Research, University of Nottingham, Nottingham NG7 2UH, UK
    Proc Nutr Soc 66:442-50. 2007
    ....
  28. ncbi request reprint Cytokines and cytokine receptors in fetal growth and development
    M E Symonds
    Academic Division of Child Health, School of Human Development, University Hospital, Nottingham NG7 2UH, U K
    Biochem Soc Trans 29:33-7. 2001
    ..An increased understanding of these interactions is likely to have important implications for a number of potentially pathological conditions, including infection, obesity and hypertension...
  29. ncbi request reprint Endocrine and nutritional regulation of fetal adipose tissue development
    M E Symonds
    Academic Division of Child Health, School of Human Development, University Hospital, Nottingham NG7 2UH, UK
    J Endocrinol 179:293-9. 2003
    ..The pronounced nutritional sensitivity of fetal adipose tIssue to both increased and decreased maternal nutrition may explain why the consequences of an adverse nutritional environment persist into later life...
  30. ncbi request reprint Prolactin receptor gene expression and foetal adipose tissue
    M E Symonds
    Division of Child Health, School of Human Development, University Hospital, Queen s Medical Centre, Nottingham, UK
    J Neuroendocrinol 10:885-90. 1998
    ..This indicates that prolactin may play an important role in the growth and maturation of foetal adipose tissue which occurs before birth...
  31. ncbi request reprint Differential effects of leptin administration on the abundance of UCP2 and glucocorticoid action during neonatal development
    M G Gnanalingham
    Centre for Reproduction and Early Life, Institute of Clinical Research, University of Nottingham, Nottingham NG7 2UH, UK
    Am J Physiol Endocrinol Metab 289:E1093-100. 2005
    ..These effects may be important in the development of these tissues, thereby optimizing lung function and fat growth...
  32. ncbi request reprint Maternal endocrine adaptation throughout pregnancy to nutritional manipulation: consequences for maternal plasma leptin and cortisol and the programming of fetal adipose tissue development
    J Bispham
    Academic Division of Child Health, School of Human Development, University Hospital, Nottingham NG7 2UH, United Kingdom
    Endocrinology 144:3575-85. 2003
    ..These changes may result in the offspring of NR mothers being at increased risk of obesity in later life...
  33. ncbi request reprint Chronic umbilical cord compression results in accelerated maturation of lung and brown adipose tissue in the sheep fetus during late gestation
    M G Gnanalingham
    Centre for Reproduction and Early Life, Institute of Clinical Research, University of Nottingham, Nottingham NG7 2UH, UK
    Am J Physiol Endocrinol Metab 289:E456-65. 2005
    ..In conclusion, chronic UCC results in precocious maturation of the fetal lung and BAT mitochondria, an adaptation largely mediated by the surge in fetal plasma cortisol and catecholamines that accompanies UCC...
  34. ncbi request reprint Tissue-specific effects of leptin administration on the abundance of mitochondrial proteins during neonatal development
    M G Gnanalingham
    Centre for Reproduction and Early Life, Institute of Clinical Research, University of Nottingham, Nottingham NG7 2UH, UK
    J Endocrinol 187:81-8. 2005
    ..These effects may be important in the regulation of neonatal tissue development and potentially for optimising metabolic control mechanisms in later life...
  35. pmc Maternal nutrient restriction between early and midgestation and its impact upon appetite regulation after juvenile obesity
    S P Sebert
    Centre for Reproduction and Early Life, Institute for Clinical Research, University Hospital, Nottingham, UK
    Endocrinology 150:634-41. 2009
    ..The extent to which this adaptive response may benefit the offspring or result in an exacerbated risk of type 2 diabetes remains to be established...
  36. pmc Influence of maternal pre-pregnancy body composition and diet during early-mid pregnancy on cardiovascular function and nephron number in juvenile sheep
    G S Gopalakrishnan
    Centre for Reproduction and Early Life, Institute of Clinical Research, University Hospital, Nottingham NG7 2UH, UK
    Br J Nutr 94:938-47. 2005
    ..Our data suggest that maternal body composition around conception is as important as the level of nutrient intake during early pregnancy in programming later cardiovascular health...
  37. ncbi request reprint Ontogeny and nutritional programming of mitochondrial proteins in the ovine kidney, liver and lung
    D P Yakubu
    Institute of Clinical Research, Centre for Reproduction and Early Life, University of Nottingham, Nottingham NG7 2UH, UK
    Reproduction 134:823-30. 2007
    ..The divergence in mitochondrial response between tissues to maternal nutrient restriction early in pregnancy further reflects these differential ontogenies...
  38. pmc Increased uncoupling protein-2 mRNA abundance and glucocorticoid action in adipose tissue in the sheep fetus during late gestation is dependent on plasma cortisol and triiodothyronine
    M G Gnanalingham
    Centre for Reproduction and Early Life, Institute of Clinical Research, University of Nottingham NG7 2UH, UK
    J Physiol 567:283-92. 2005
    ..In conclusion, plasma cortisol and T3 are both required for the late gestation rise in UCP2 mRNA and differentially regulate glucocorticoid action in fetal adipose tissue in the sheep during late gestation...
  39. doi request reprint Influence of prenatal nutrition and obesity on tissue specific fat mass and obesity-associated (FTO) gene expression
    S P Sebert
    Early Life Nutrition Research Unit, School of Clinical Sciences, Academic Child Health, University Hospital, Nottingham NG7 2UH, UK
    Reproduction 139:265-74. 2010
    ..These findings extend information gained from human epidemiology and provide new insights into the regulation of in vivo energy metabolism to prevent obesity...
  40. ncbi request reprint Different effects of maternal parity, cold exposure and nutrient restriction in late pregnancy on the abundance of mitochondrial proteins in the kidney, liver and lung of postnatal sheep
    D P Yakubu
    Centre for Reproduction and Early Life, Institute of Clinical Research, University Hospital, Nottingham NG7 2UH, UK
    Reproduction 133:1241-52. 2007
    ....
  41. ncbi request reprint Nutritional manipulation between early to mid-gestation: effects on uncoupling protein-2, glucocorticoid sensitivity, IGF-I receptor and cell proliferation but not apoptosis in the ovine placenta
    M G Gnanalingham
    Institute of Clinical Research, Centre for Reproduction and Early Life, University of Nottingham, Nottingham NG7 2UH, UK
    Reproduction 134:615-23. 2007
    ....
  42. ncbi request reprint Prolactin, the prolactin receptor and uncoupling protein abundance and function in adipose tissue during development in young sheep
    S Pearce
    Centre for Reproduction and Early Life, Institute of Clinical Research, Queen s Medical Centre, University Hospital, Nottingham, NG7 2UH, UK
    J Endocrinol 184:351-9. 2005
    ..In conclusion, we have demonstrated a close relationship between the ontogeny of UCP1 and the PRLR. Exogenous PRL administration elicits a thermogenic effect suggesting an important role for the PRLR in regulating UCP1 function...
  43. pmc Ontogeny and nutritional programming of uncoupling protein-2 and glucocorticoid receptor mRNA in the ovine lung
    M G Gnanalingham
    Centre for Reproduction and Early Life, Institute of Clinical Research, University of Nottingham, UK
    J Physiol 565:159-69. 2005
    ....
  44. ncbi request reprint Maternal nutritional programming of fetal adipose tissue development: differential effects on messenger ribonucleic acid abundance for uncoupling proteins and peroxisome proliferator-activated and prolactin receptors
    J Bispham
    Centre for Reproduction and Early Life, Institute of Clinical Research, University of Nottingham, United Kingdom
    Endocrinology 146:3943-9. 2005
    ..In conclusion, we have shown, for the first time, differential effects of maternal nutrition on key regulatory components of fetal fat metabolism...
  45. ncbi request reprint Maternal nutrient restriction in early pregnancy programs hepatic mRNA expression of growth-related genes and liver size in adult male sheep
    M A Hyatt
    Institute of Clinical Research, Centre for Reproduction and Early Life, The University of Nottingham, Nottingham, UK
    J Endocrinol 192:87-97. 2007
    ..In conclusion, maternal nutrient restriction in early gestation results in adult offspring with smaller livers. This may be mediated by alterations in both hepatic mitogenic and apoptotic factors...
  46. ncbi request reprint Programming of adult cardiovascular function after early maternal undernutrition in sheep
    G S Gopalakrishnan
    Academic Division of Child Health, School of Human Development, Univ Hospital, Nottingham NG7 2UH, UK
    Am J Physiol Regul Integr Comp Physiol 287:R12-20. 2004
    ..Circulating leptin correlated well with fat mass and increased more after vasoconstrictor infusion in NR sheep. In conclusion, early NR has been shown to program aspects of cardiovascular control and adipocyte function in adult sheep...
  47. pmc Hypertension and impaired renal function accompany juvenile obesity: the effect of prenatal diet
    P J Williams
    School of Human Development, Centre for Reproduction and Early Life, University Hospital, Nottingham, UK
    Kidney Int 72:279-89. 2007
    ..Our data indicate that juvenile obesity per se leads to systemic hypertension and renal structural and functional pathology. Prenatal undernutrition effectively abolishes any renal histopathology associated with juvenile obesity...
  48. ncbi request reprint Hormonal and nutritional regulation of adipose tissue mitochondrial development and function in the newborn
    A Mostyn
    Centre for Reproduction and Early Life, Institute of Clinical Research, University Hospital, Nottingham, United Kingdom
    Exp Clin Endocrinol Diabetes 112:2-9. 2004
    ..It could also add substantially to our understanding of pathological conditions such as obesity and non-insulin dependent diabetes...
  49. ncbi request reprint Developmental regulation of the lung in preparation for life after birth: hormonal and nutritional manipulation of local glucocorticoid action and uncoupling protein-2
    M G Gnanalingham
    Centre for Reproduction and Early Life, Institute of Clinical Research, University of Nottingham, Nottingham NG7 2UH, UK
    J Endocrinol 188:375-86. 2006
    ..As a consequence, changes in glucocorticoid sensitivity and mitochondrial protein abundance have the potential to be used to identify those at greatest risk of developing later lung disease...
  50. pmc Effect of maternal nutrient restriction from early to midgestation on cardiac function and metabolism after adolescent-onset obesity
    L L Y Chan
    School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington, Leicestershire LE12 5RD, UK
    Am J Physiol Regul Integr Comp Physiol 296:R1455-63. 2009
    ....
  51. ncbi request reprint Maternal nutritional manipulation of placental growth and glucose transporter 1 (GLUT-1) abundance in sheep
    J Dandrea
    Academic Division of Child Health, School of Human Development, University Hospital, Queen's Medical Centre, Nottingham NG7 2UH, UK
    Reproduction 122:793-800. 2001
    ....
  52. ncbi request reprint Influence of cortisol on adipose tissue development in the fetal sheep during late gestation
    A Mostyn
    Academic Division of Child Health, School of Human Development, Queen s Medical Centre, University Hospital, Nottingham NG7 2UH, UK
    J Endocrinol 176:23-30. 2003
    ..It remains to be established whether effects on UCP1 protein are directly regulated by cortisol alone or mediated by other anabolic fetal hormones such as triiodothyronine...
  53. ncbi request reprint Fetal and neonatal adipose maturation: a primary site of cytokine and cytokine-receptor action
    T Stephenson
    Academic Division of Child Health, School of Human Development, University Hospital, Nottingham NG7 2UH
    Biochem Soc Trans 29:80-5. 2001
    ....
  54. ncbi request reprint The effect of maternal prolactin infusion during pregnancy on fetal adipose tissue development
    H Budge
    Academic Division of Child Health, School of Human Development, Queen s Medical Centre, University Hospital, Nottingham NG7 2UH, UK
    J Endocrinol 174:427-33. 2002
    ....
  55. doi request reprint The differential effects of the timing of maternal nutrient restriction in the ovine placenta on glucocorticoid sensitivity, uncoupling protein 2, peroxisome proliferator-activated receptor-gamma and cell proliferation
    M Yiallourides
    Early Life Nutrition Research Unit, Academic Child Health, School of Clinical Sciences, University Hospital, Nottingham NG72UH, UK
    Reproduction 138:601-8. 2009
    ..These compensatory placental responses may serve to maintain fetal growth but could result in adverse adaptations such as the early onset of the metabolic syndrome in later life...
  56. ncbi request reprint Nutritional manipulation of fetal adipose tissue deposition and uncoupling protein 1 messenger RNA abundance in the sheep: differential effects of timing and duration
    H Budge
    Academic Division of Child Health, School of Human Development, University Hospital, Nottingham, NG7 2UH United Kingdom
    Biol Reprod 71:359-65. 2004
    ..In conclusion, there are differential effects of maternal and therefore fetal nutrient restriction on UCP1 mRNA expression and fetal fat mass and these effects are dependent on the timing and duration of nutrient restriction...
  57. doi request reprint Suboptimal maternal nutrition during early fetal kidney development specifically promotes renal lipid accumulation following juvenile obesity in the offspring
    H P Fainberg
    Early Life Nutrition Research Unit, Academic Child Health, School of Medicine, University Hospital, Nottingham NG7 2UH, UK
    Reprod Fertil Dev 25:728-36. 2013
    ....
  58. ncbi request reprint The role of leptin in the transition from fetus to neonate
    A Mostyn
    Academic Division of Child Health, School of Human Development, University Hospital, Nottingham, UK
    Proc Nutr Soc 60:187-94. 2001
    ....
  59. ncbi request reprint Ontogeny and nutritional manipulation of mitochondrial protein abundance in adipose tissue and the lungs of postnatal sheep
    A Mostyn
    Academic Division of Child Health, School of Human Development, Queen s Medical Centre, University Hospital, Nottingham NG7 2UH, UK
    Br J Nutr 90:323-8. 2003
    ..These mitochondrial adaptations within both adipose tissue and the lungs of offspring born to previously nutrient-restricted mothers may compromise adipose tissue and lung function during periods of environmental stress...
  60. ncbi request reprint Impact of maternal undernutrition and fetal number on glucocorticoid, growth hormone and insulin-like growth factor receptor mRNA abundance in the ovine fetal kidney
    K A Brennan
    Centre for Reproduction and Early Life, Institute of Clinical Research, Queen s Medical Centre, Nottingham NG7 2UH, UK
    Reproduction 129:151-9. 2005
    ..This may impact on later kidney development and function...
  61. doi request reprint Effects of maternal cold exposure and nutrient restriction on the ghrelin receptor, the GH-IGF axis, and metabolic regulation in the postnatal ovine liver
    M A Hyatt
    Academic Division of Child Health, School of Human Development, Institute of Clinical Research, Centre for Reproduction and Early Life, University Hospital, Nottingham NG7 2UH, UK
    Reproduction 135:723-32. 2008
    ..In conclusion, we have shown that maternal cold exposure and NR have different effects on the hepatic GH-IGF and metabolic axis that may contribute to changes in liver growth over the first month of life...
  62. ncbi request reprint Effect of periconceptional undernutrition and gender on hypothalamic-pituitary-adrenal axis function in young adult sheep
    D S Gardner
    Centre for Reproduction and Early Life, Schools of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington Campus, Sutton Bonington, Leicestershire LE12 5RD, UK
    J Endocrinol 190:203-12. 2006
    ..In conclusion, the present study has shown that periconceptional undernutrition of sheep has only a minor influence on HPA axis function in their young adult offspring when considered alongside the effect of gender per se...
  63. ncbi request reprint Programming of glucose-insulin metabolism in adult sheep after maternal undernutrition
    D S Gardner
    School of Human Development, Academic Division of Child Health, University Hospital, Nottingham, NG7 2UH, UK
    Am J Physiol Regul Integr Comp Physiol 289:R947-54. 2005
    ..In conclusion, prenatal undernutrition, specifically during late gestation, affects adult offspring intermediary metabolism, and, in particular, glucose-insulin homeostasis...
  64. ncbi request reprint Ontogeny and nutritional programming of the hepatic growth hormone-insulin-like growth factor-prolactin axis in the sheep
    Melanie A Hyatt
    Center for Reproduction and Early Life, Institute of Clinical Research, The University of Nottingham, Nottingham, UK
    Endocrinology 148:4754-60. 2007
    ..These could contribute to changes in liver function during adult life...
  65. ncbi request reprint The influence of maternal nutrient restriction in early to mid-pregnancy on placental and fetal development in sheep
    L Heasman
    Academic Division of Child Health, School of Human Development, University Hospital, Queen s Medical Centre, Nottingham, UK
    Proc Nutr Soc 58:283-8. 1999
    ..Maternal nutrition during pregnancy plays a pivotal role in the regulation of fetal and placental development in sheep, and therefore has the potential to influence both short- and longer-term health outcomes...
  66. pmc Factors affecting birth weight in sheep: maternal environment
    D S Gardner
    Centre for Reproduction and Early Life, Schools of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington Campus, Sutton Bonington, Leicestershire LE12 5RD, UK
    Reproduction 133:297-307. 2007
    ....
  67. ncbi request reprint Ontogeny and nutritional programming of adiposity in sheep: potential role of glucocorticoid action and uncoupling protein-2
    Muhuntha G Gnanalingham
    Centre for Reproduction and Early Life, Institute of Chemical Research, University of Nottingham, United Kingdom
    Am J Physiol Regul Integr Comp Physiol 289:R1407-15. 2005
    ..We conclude that the continual rise in glucocorticoid action and fat mass after birth may underlie the development of later obesity. The magnitude of this adaptation is partly dependent on maternal food intake through pregnancy...
  68. doi request reprint The conflicting effects of maternal nutrient restriction and early-life obesity on renal health
    H P Fainberg
    School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington Campus, Leicestershire LE12 5RD, UK
    Proc Nutr Soc 70:268-75. 2011
    ....
  69. pmc Differential effects of maternal nutrient restriction through pregnancy on kidney development and later blood pressure control in the resulting offspring
    K A Brennan
    Centre for Reproduction and Early Life, Institute of Clinical Research, Queen s Medical Centre, Nottingham, United Kingdom
    Am J Physiol Regul Integr Comp Physiol 295:R197-205. 2008
    ..In conclusion, maternal nutrient restriction suppressed renal PG concentrations in the offspring, and this was associated with suppressed kidney growth and development and decreased blood pressure...
  70. doi request reprint The influence of maternal protein nutrition on offspring development and metabolism: the role of glucocorticoids
    K Almond
    Academic Division of Child Health, School of Clinical Sciences, E Floor East Block, University Hospital, Nottingham NG7 2UH, UK
    Proc Nutr Soc 71:198-203. 2012
    ..This increase in GC sensitivity was similar to the programming effects observed following maternal protein restriction or global undernutrition during pregnancy...
  71. doi request reprint Impact of early onset obesity and hypertension on the unfolded protein response in renal tissues of juvenile sheep
    Don Sharkey
    Centre for Reproduction and Early Life, Institute of Clinical Research, University of Nottingham, Nottingham, United Kingdom
    Hypertension 53:925-31. 2009
    ..The UPR may prove to be a useful therapeutic target for the treatment and prevention of obesity-related nephropathy and associated hypertension, thereby reducing the burden of end-stage renal disease...
  72. doi request reprint Influence of birth weight on gene regulators of lipid metabolism and utilization in subcutaneous adipose tissue and skeletal muscle of neonatal pigs
    P J Williams
    Institute of Clinical Research, Centre for Reproduction and Early Life, University Hospital, Nottingham NG72UH, UK
    Reproduction 138:609-17. 2009
    ..It remains to be seen whether these developmental changes alter an individual's susceptibility to metabolic syndrome...
  73. ncbi request reprint Fetal mechanisms that lead to later hypertension
    D S Gardner
    Centre for Reproduction and Early Life, School of Veterinary Medicine and Science, Sutton Bonington, University of Nottingham, UK
    Curr Drug Targets 8:894-905. 2007
    ..Within the review we shall also present an opinion on the differing animal models that are currently employed to address developmental programming and introduce a conceptual framework that synthesises current available evidence...
  74. pmc Maternal nutrient restriction during early fetal kidney development attenuates the renal innate inflammatory response in obese young adult offspring
    Don Sharkey
    Early Life Nutrition Research Group, Academic Child Health, University of Nottingham, Nottingham, United Kingdom
    Am J Physiol Renal Physiol 297:F1199-207. 2009
    ..A better understanding of maternal nutrition and the in utero nutritional environment may offer therapeutic strategies aimed at reducing the burden of later kidney disease...
  75. ncbi request reprint Session on 'Obesity'. Adipose tissue development, nutrition in early life and its impact on later obesity
    H Budge
    Centre for Reproduction and Early Life, Institute of Clinical Research, University Hospital, Nottingham NG7 2UH, UK
    Proc Nutr Soc 68:321-6. 2009
    ....
  76. ncbi request reprint Experimental evidence for long-term programming effects of early diet
    M E Symonds
    Centre for Reproduction and Early Life, Institute of Clinical Research, University Hospital, Nottingham, NG7 2UH, United Kingdom
    Adv Exp Med Biol 569:24-32. 2005
    ..In conclusion, global nutrient restriction confined to periods of early development programmes adult physiology in a manner that may predispose to later disease given the appropriate environmental stimuli...
  77. ncbi request reprint Ambient temperature, maternal dexamethasone, and postnatal ontogeny of leptin in the neonatal lamb
    Jayson Bispham
    Academic Division of Child Health, School of Human Development, University Hospital, Queen s Medical Centre, Nottingham, NG7 2UH, UK
    Pediatr Res 52:85-90. 2002
    ....
  78. ncbi request reprint Differential effects of fetal number and maternal nutrition in late gestation on prolactin receptor abundance and adipose tissue development in the neonatal lamb
    Helen Budge
    Academic Division of Child Health, School of Human Development, University Hospital, Queen s Medical Centre, Nottingham, United Kingdom
    Pediatr Res 53:302-8. 2003
    ..An increase in fetal number results in greater PRLR abundance, which, in conjunction with a decrease in maternal nutrition, results in up-regulation of specific mitochondrial proteins...
  79. ncbi request reprint Maternal nutritional programming of fetal adipose tissue development: long-term consequences for later obesity
    Helen Budge
    Centre for Reproduction and Early Life, Institute of Clinical Research, University of Nottingham, United Kingdom
    Birth Defects Res C Embryo Today 75:193-9. 2005
    ..The extent to which changes in dietary habits, both during pregnancy and in later life, may act to contribute to the current explosion in childhood and adult obesity remains a scientific and public health challenge to us all...
  80. ncbi request reprint Differential effects of leptin on thermoregulation and uncoupling protein abundance in the neonatal lamb
    Alison Mostyn
    Academic Division of Child Health, School of Human Development, University Hospital, Queen s Medical Centre, Nottingham, NG7 2UH
    FASEB J 16:1438-40. 2002
    ..In conclusion, leptin administration to neonatal lambs improves thermoregulation and promotes the loss of UCP1 in brown adipose tissue...
  81. ncbi request reprint The effects of pregnancy and maternal nutrition on the maternal renin-angiotensin system in sheep
    J Dandrea
    Academic Division of Child Health, School of Human Development, University Hospital, Queen s Medical Centre, Nottingham NG7 2UH, UK
    Exp Physiol 87:353-9. 2002
    ..Following the restoration of maternal diet after 80 days gestation, PRC gradually rose to peak at term. These adaptations in the maternal RAS during the critical period of placental growth may have long-term effects on fetal development...
  82. ncbi request reprint Influence of genotype on the differential ontogeny of uncoupling protein 2 and 3 in subcutaneous adipose tissue and muscle in neonatal pigs
    A Mostyn
    Department of Agricultural Sciences, Imperial College London, Wye Campus, Ashford, Kent TN25 5AH, UK
    J Endocrinol 183:121-31. 2004
    ..In conclusion, we have demonstrated that porcine genotype influences the expression and abundance of UCP2 and 3, an influence which may, in part, be due to the distinctive endocrine profiles associated with each genotype...
  83. ncbi request reprint Ontogeny and nutritional manipulation of the hepatic prolactin-growth hormone-insulin-like growth factor axis in the ovine fetus and in neonate and juvenile sheep
    Melanie A Hyatt
    Centre for Reproduction and Early Life, Institute of Clinical Research and Children s Brain Tumour Research Centre, University Hospital, Nottingham NG7 2UH, UK
    Proc Nutr Soc 63:127-35. 2004
    ....
  84. ncbi request reprint Influence of porcine genotype on the abundance of thyroid hormones and leptin in sow milk and its impact on growth, metabolism and expression of key adipose tissue genes in offspring
    Alison Mostyn
    Institute of Clinical Research, Centre for Reproduction and Early Life, University Hospital, Nottingham NG7 2UH, UK
    J Endocrinol 190:631-9. 2006
    ....
  85. ncbi request reprint Effects of maternal parity and late gestational nutrition on mRNA abundance for growth factors in the liver of postnatal sheep
    Melanie A Hyatt
    Centre for Reproduction and Early Life, Institute of Clinical Research, The University of Nottingham, Nottingham, UK
    Am J Physiol Regul Integr Comp Physiol 292:R1934-42. 2007
    ..First-born offspring appear to exhibit a resetting of the endocrine control of hepatic growth within the HGF and GH-IGF axis, which could have later consequences after their growth has caught up...
  86. ncbi request reprint Maternal nutrient restriction alters renal development and blood pressure regulation of the offspring
    Kathryn A Brennan
    Perinatal Research Centre, Department of Obstetrics and Gynecology, University of Alberta, Edmonton, Canada
    Proc Nutr Soc 65:116-24. 2006
    ..In conclusion, NR does affect the GH-IGF and PG axes, and these changes may be important in the nutritional programming of renal functioning and adult blood pressure control...
  87. ncbi request reprint Maternal nutrient restriction is not equivalent to maternal biological stress
    Helen Budge
    Centre for Reproduction and Early Life, Institute of Clinical Research, University of Nottingham, UK
    Curr Drug Targets 8:888-93. 2007
    ....
  88. ncbi request reprint Influence of size at birth on the endocrine profiles and expression of uncoupling proteins in subcutaneous adipose tissue, lung, and muscle of neonatal pigs
    Alison Mostyn
    Centre for Reproduction and Early Life, Institute of Clinical Research, Academic Division of Child Health, School of Human Development, University Hospital, Nottingham, NG7 2UH United Kingdom
    Am J Physiol Regul Integr Comp Physiol 288:R1536-42. 2005
    ..In conclusion, low birth weight is associated with tissue-specific effects on UCP expression. It remains to be established whether these subsequently contribute to pathological conditions such as diabetes...
  89. doi request reprint Early programming of adipose tissue function: a large-animal perspective
    Alison Mostyn
    Early Life Nutrition Research Unit, Academic Child Health, Division of Human Development and Nottingham Respiratory Medicine Biomedical Research Unit, School of Clinical Sciences, Queen s Medical Centre, University Hospitals, Nottingham NG7 2UH, UK
    Proc Nutr Soc 68:393-400. 2009
    ..The experimental models, potential mechanisms and regulators of the early programming of adipose tissue in large mammalian species will be summarised in the present review...
  90. pmc Peri-implantation undernutrition programs blunted angiotensin II evoked baroreflex responses in young adult sheep
    David S Gardner
    Center for Reproduction and Early Life, Institute of Clinical Research, University Hospital, Nottingham, United Kingdom
    Hypertension 43:1290-6. 2004
    ..The data have broad implications for the health outcome of those offspring from mothers who were poorly nourished during early, often unknown pregnancy and for embryos artificially manipulated because of infertility treatment...
  91. doi request reprint Maternal nutrient restriction during pregnancy differentially alters the unfolded protein response in adipose and renal tissue of obese juvenile offspring
    Don Sharkey
    Centre for Reproduction and Early Life, Institute of Clinical Research, University of Nottingham, Nottingham, UK
    FASEB J 23:1314-24. 2009
    ..In conclusion, obesity-related activation of the UPR can be determined by the in utero nutritional environment, demonstrating organ-specific effects dependent on the developmental phase targeted within the fetus...
  92. ncbi request reprint Differential effects of age and sex on the postnatal responsiveness of brown adipose tissue to prolactin administration in rats
    Sarah Pearce
    Academic Division of Child Health, School of Human Development, University Hospital, Queen s Medical Centre, Nottingham NG7 2UH, UK
    Exp Physiol 88:527-31. 2003
    ..In females, prolactin actually caused a reduction in UCP1 suggesting that in rats it is only prior to birth that prolactin has a stimulatory role on brown adipose tissue development...
  93. doi request reprint Adipose tissue inflammation: developmental ontogeny and consequences of gestational nutrient restriction in offspring
    Don Sharkey
    Centre for Reproduction and Early Life, Institute of Clinical Research, University of Nottingham NG7 2UH, United Kingdom
    Endocrinology 150:3913-20. 2009
    ..Establishing the optimal maternal diet during pregnancy could reduce the burden of later adult disease in the offspring...