H E Syddall

Summary

Affiliation: University of Southampton
Country: UK

Publications

  1. pmc Social inequalities in osteoporosis and fracture among community-dwelling older men and women: findings from the Hertfordshire Cohort Study
    Holly E Syddall
    MRC Lifecourse Epidemiology Unit, Southampton General Hospital, University of Southampton, Southampton SO16 6YD, UK
    Arch Osteoporos 7:37-48. 2012
  2. pmc Hertfordshire sarcopenia study: design and methods
    Harnish P Patel
    Academic Geriatric Medicine, University of Southampton, Southampton General Hospital, Southampton, UK
    BMC Geriatr 10:43. 2010
  3. pmc The SF-36: a simple, effective measure of mobility-disability for epidemiological studies
    H E Syddall
    MRC Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, Southampton, UK
    J Nutr Health Aging 13:57-62. 2009
  4. doi request reprint Social inequalities in grip strength, physical function, and falls among community dwelling older men and women: findings from the Hertfordshire Cohort Study
    Holly Syddall
    Epidemiology Resource Centre, University of Southampton, Southhampton General Hospital, Southhampton SO16 6YD, UK
    J Aging Health 21:913-39. 2009
  5. doi request reprint Relationship between customary physical activity, muscle strength and physical performance in older men and women: findings from the Hertfordshire Cohort Study
    H J Martin
    MRC Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, Southampton, Hampshire, UK
    Age Ageing 37:589-93. 2008
  6. doi request reprint Physical performance and physical activity in older people: are developmental influences important?
    H J Martin
    MRC Epidemiology Resource Centre, University of Southampton, Southampton, UK
    Gerontology 55:186-93. 2009
  7. doi request reprint Is grip strength a good marker of physical performance among community-dwelling older people?
    P J Stevens
    Academic Geriatric Medicine, School of Medicine, University of Southampton, UK
    J Nutr Health Aging 16:769-74. 2012
  8. doi request reprint Bone health and deterioration in quality of life among participants from the Hertfordshire cohort study
    E M Dennison
    MRC Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, Southampton, SO16 6YD, UK
    Osteoporos Int 21:1817-24. 2010
  9. ncbi request reprint Cohort profile: the Hertfordshire cohort study
    H E Syddall
    MRC Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK
    Int J Epidemiol 34:1234-42. 2005
  10. pmc Lipid profile, obesity and bone mineral density: the Hertfordshire Cohort Study
    E M Dennison
    MRC Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK
    QJM 100:297-303. 2007

Detail Information

Publications32

  1. pmc Social inequalities in osteoporosis and fracture among community-dwelling older men and women: findings from the Hertfordshire Cohort Study
    Holly E Syddall
    MRC Lifecourse Epidemiology Unit, Southampton General Hospital, University of Southampton, Southampton SO16 6YD, UK
    Arch Osteoporos 7:37-48. 2012
    ..Public health strategies for prevention of osteoporosis should focus on the whole population...
  2. pmc Hertfordshire sarcopenia study: design and methods
    Harnish P Patel
    Academic Geriatric Medicine, University of Southampton, Southampton General Hospital, Southampton, UK
    BMC Geriatr 10:43. 2010
    ....
  3. pmc The SF-36: a simple, effective measure of mobility-disability for epidemiological studies
    H E Syddall
    MRC Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, Southampton, UK
    J Nutr Health Aging 13:57-62. 2009
    ..The physical functioning (PF) domain of the established and widely used Short Form-36 (SF-36) questionnaire asks about limitations on ten mobility activities...
  4. doi request reprint Social inequalities in grip strength, physical function, and falls among community dwelling older men and women: findings from the Hertfordshire Cohort Study
    Holly Syddall
    Epidemiology Resource Centre, University of Southampton, Southhampton General Hospital, Southhampton SO16 6YD, UK
    J Aging Health 21:913-39. 2009
    ..01). Discussion. There are social inequalities in grip strength, PF, and falls among older people. Interventions should consider the contribution of social inequalities to the problem...
  5. doi request reprint Relationship between customary physical activity, muscle strength and physical performance in older men and women: findings from the Hertfordshire Cohort Study
    H J Martin
    MRC Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, Southampton, Hampshire, UK
    Age Ageing 37:589-93. 2008
  6. doi request reprint Physical performance and physical activity in older people: are developmental influences important?
    H J Martin
    MRC Epidemiology Resource Centre, University of Southampton, Southampton, UK
    Gerontology 55:186-93. 2009
    ..Reduced physical performance and physical activity have serious health consequences, but adult determinants do not fully explain variation in older people...
  7. doi request reprint Is grip strength a good marker of physical performance among community-dwelling older people?
    P J Stevens
    Academic Geriatric Medicine, School of Medicine, University of Southampton, UK
    J Nutr Health Aging 16:769-74. 2012
    ..As muscle strength is central to physical performance, we explored whether grip strength could be used as a marker of the Short Physical Performance Battery...
  8. doi request reprint Bone health and deterioration in quality of life among participants from the Hertfordshire cohort study
    E M Dennison
    MRC Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, Southampton, SO16 6YD, UK
    Osteoporos Int 21:1817-24. 2010
    ..We found deterioration in the mental health domain over follow-up in osteoporotic men (but not women) compared with other groups (relative rate ratio=5.78, 95% confidence interval (CI) 1.78-19.2)...
  9. ncbi request reprint Cohort profile: the Hertfordshire cohort study
    H E Syddall
    MRC Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK
    Int J Epidemiol 34:1234-42. 2005
  10. pmc Lipid profile, obesity and bone mineral density: the Hertfordshire Cohort Study
    E M Dennison
    MRC Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK
    QJM 100:297-303. 2007
    ..Body mass index (BMI) and bone mineral density (BMD) are positively correlated in several studies, but few data relate bone density, lipid profile and anthropometric measures...
  11. ncbi request reprint Relationships between SF-36 health profile and bone mineral density: the Hertfordshire Cohort Study
    E M Dennison
    MRC Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK
    Osteoporos Int 17:1435-42. 2006
    ..05], but no other relationships were significant. Poorer functioning (assessed by SF-36 questionnaire) is associated with lower total femoral BMD in older men (but less so in women) after adjustment for lifestyle factors and comorbidity...
  12. pmc The relative importance of whole body vibration and occupational lifting as risk factors for low-back pain
    K T Palmer
    MRC Environmental Epidemiology Unit, Southampton, UK
    Occup Environ Med 60:715-21. 2003
    ....
  13. pmc Raynaud's phenomenon, vibration induced white finger, and difficulties in hearing
    K T Palmer
    MRC Environmental Epidemiology Unit, Community Clinical Sciences, Southhampton General Hospital, University of Southampton, SO16 6YD, UK
    Occup Environ Med 59:640-2. 2002
    ..An association has previously been reported between finger blanching and hearing difficulties, but only in workers with exposure to noise and hand transmitted vibration (HTV)...
  14. ncbi request reprint Exposure to hand-transmitted vibration and pain in the neck and upper limbs
    K T Palmer
    MRC Environmental Epidemiology Unit, Community Clinical Sciences, University of Southampton, Southampton, UK
    Occup Med (Lond) 51:464-7. 2001
    ..7 versus 1.8 for neck pain). This accords with the pattern of transmission of HTV to the upper limb, although a confounding effect from other ergonomic risk factors cannot be discounted...
  15. ncbi request reprint Type 2 diabetes mellitus is associated with increased axial bone density in men and women from the Hertfordshire Cohort Study: evidence for an indirect effect of insulin resistance?
    E M Dennison
    MRC Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, Southampton, SO16 6YD, UK
    Diabetologia 47:1963-8. 2004
    ..Previous studies have suggested that the high bone density often observed in type 2 diabetic patients may be explained by insulin resistance. We explored this hypothesis in the Hertfordshire Cohort Study...
  16. pmc Grip strength and the metabolic syndrome: findings from the Hertfordshire Cohort Study
    A A Sayer
    MRC Epidemiology Resource Centre, University of Southampton, Southampton SO16 6YD, UK
    QJM 100:707-13. 2007
    ..Sarcopenia, the loss of muscle mass and strength with age, is significantly associated with type 2 diabetes in older people...
  17. ncbi request reprint Investigating the role of the growth hormone-insulin-like growth factor (GH-IGF) axis as a determinant of male bone mineral density (BMD)
    M B R Patel
    MRC Environmental Epidemiology Unit, Southampton General Hospital, Southampton SO16 6YD, UK
    Bone 37:833-41. 2005
    ..Serum IGF-I is often low in men with osteoporosis, which may be attributable to GH hypo-secretion or hepatic GH insensitivity. We studied the GH-IGF axis in depth to look for evidence to support these hypotheses...
  18. pmc Urinary CTX-II and glucosyl-galactosyl-pyridinoline are associated with the presence and severity of radiographic knee osteoarthritis in men
    K M Jordan
    Bone and Joint, MRC Epidemiology Resource Centre, Southampton University, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK
    Ann Rheum Dis 65:871-7. 2006
    ..To investigate the association between biochemical markers of bone, cartilage, and synovial turnover with the presence and severity of knee osteoarthritis (OA) in men...
  19. pmc Cigarette smoking, occupational exposure to noise, and self reported hearing difficulties
    K T Palmer
    MRC Environmental Epidemiology Unit, Community Clinical Sciences, University of Southampton, UK
    Occup Environ Med 61:340-4. 2004
    ..To explore the interaction of smoking and occupational exposure to noise as risk factors for hearing difficulty in the general population...
  20. ncbi request reprint Serum insulin-like growth factor-I concentrations in late middle age: no association with birthweight in three UK cohorts
    R I G Holt
    Fetal Origins of Adult Disease Division, School of Medicine, University of Southampton, Southampton, UK
    Acta Physiol Scand 180:359-66. 2004
    ..Fetal programming of the growth hormone-insulin-like growth factor (GH-IGF) axis may provide a mechanism for these epidemiological findings...
  21. ncbi request reprint Plasma leptin concentration and change in bone density among elderly men and women: the Hertfordshire Cohort Study
    E M Dennison
    MRC Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, United Kingdom
    Calcif Tissue Int 74:401-6. 2004
    ....
  22. ncbi request reprint Polymorphism in the growth hormone gene, weight in infancy, and adult bone mass
    E M Dennison
    Medical Research Council Epidemiology Resource Center, University of Southampton, Southampton General Hospital, Southampton, United Kingdom SO16 6YD
    J Clin Endocrinol Metab 89:4898-903. 2004
    ..The interaction with infant weight suggests that early environment may influence the effect of GH1 genotype on bone loss...
  23. ncbi request reprint Birth weight, infant weight gain, and cause-specific mortality: the Hertfordshire Cohort Study
    H E Syddall
    Medical Research Council Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, Southampton, United Kingdom
    Am J Epidemiol 161:1074-80. 2005
    ..Overall, a one-standard-deviation increase in birth weight reduced all-cause mortality risk by age 75 years by 0.86% for both men and women...
  24. doi request reprint Developmental influences, muscle morphology, and sarcopenia in community-dwelling older men
    H P Patel
    MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, UK
    J Gerontol A Biol Sci Med Sci 67:82-7. 2012
    ..However, underlying mechanisms are unknown. Our objective was to determine whether low birth weight is associated with altered skeletal muscle morphology in older men...
  25. pmc Angiotensin II type I receptor gene polymorphism: anthropometric and metabolic syndrome traits
    M R Abdollahi
    Human Genetics Division, Duthie Building, Southampton General Hospital, Tremona Rd, Southampton, SO16 6YD, UK
    J Med Genet 42:396-401. 2005
    ..Angiotensin II type I receptor (AGTR1) A1166C has previously been associated with the development of hypertension and coronary disease, but its metabolic effects have not been investigated...
  26. pmc Cigarette smoking, birthweight and osteoporosis in adulthood: results from the hertfordshire cohort study
    M M Moinuddin
    MRC Resource Centre, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK
    Open Rheumatol J 2:33-7. 2008
    ..04). Similar trends were seen with femoral neck BMC and lumber spine BMC.Individuals of lower birth weight may be particularly vulnerable to the effects of bone noxious stimuli such as cigarette smoking...
  27. ncbi request reprint The feasibility and acceptability of muscle biopsy in epidemiological studies: findings from the Hertfordshire Sarcopenia Study (HSS)
    Harnish Patel
    Academic Geriatric Medicine, University of Southampton, Southampton General Hospital, Southampton, UK
    J Nutr Health Aging 15:10-5. 2011
    ..Our aim was to ascertain the feasibility and acceptability of obtaining muscle tissue from healthy older people in order to ultimately identify cellular mechanisms underlying life course influences on sarcopenia...
  28. ncbi request reprint Is hand-held dynamometry useful for the measurement of quadriceps strength in older people? A comparison with the gold standard Bodex dynamometry
    H J Martin
    MRC Epidemiology Resource Centre, University of Southampton, Southampton, UK
    Gerontology 52:154-9. 2006
    ..A protocol using a novel, versatile hand-held dynamometer (HHD) has been developed to measure the quadriceps strength in a supine position...
  29. pmc Occupational exposure to noise and the attributable burden of hearing difficulties in Great Britain
    K T Palmer
    MRC Environmental Epidemiology Unit, Community Clinical Sciences, Southhampton General Hospital, University of Southampton, SO16 6YD, UK
    Occup Environ Med 59:634-9. 2002
    ....
  30. ncbi request reprint Does admission grip strength predict length of stay in hospitalised older patients?
    A Kerr
    Medicine for Older People, Southampton University Hospitals NHS Trust, Southampton, UK
    Age Ageing 35:82-4. 2006
  31. pmc Immune-endocrine biomarkers as predictors of frailty and mortality: a 10-year longitudinal study in community-dwelling older people
    D Baylis
    MRC Lifecourse Epidemiology Unit, Southampton General Hospital, University of Southampton, Tremona Road, Southampton, SO16 6YD, UK
    Age (Dordr) 35:963-71. 2013
    ..Progress towards the prevention of frailty would bring major health and socio-economic benefits at the individual and the population level...
  32. ncbi request reprint Fetal, infant, and childhood growth and adult blood pressure: a longitudinal study from birth to 22 years of age
    C M Law
    MRC Environmental Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, UK
    Circulation 105:1088-92. 2002
    ..People who are small at birth tend to have higher blood pressure in later life. However, it is not clear whether it is fetal growth restriction or the accelerated postnatal growth that often follows it that leads to higher blood pressure...