Research Topics
Species | Jason R SwedlowSummaryAffiliation: University of Dundee Country: UK Publications
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Detail Information
Publications
Innovation in biological microscopy: current status and future directionsJason R Swedlow
Wellcome Trust Centre for Gene Regulation and Expression, College of Life Sciences, University of Dundee, Dundee, Scotland, UK
Bioessays 34:333-40. 2012..As these and more new technologies appear, the challenges of delivering them to the community grows as well. I discuss some of these challenges, and the examples where openly shared technology have made an impact on the field...- The Open Microscopy Environment (OME) Data Model and XML file: open tools for informatics and quantitative analysis in biological imagingIlya G Goldberg
Laboratory of Genetics National Institute on Aging, National Institutes of Health, 333 Cassell Drive, Baltimore, MD 21224, USA
Genome Biol 6:R47. 2005..The OME Data Model, expressed in Extensible Markup Language (XML) and realized in a traditional database, is both extensible and self-describing, allowing it to meet emerging imaging and analysis needs... - Temporal profiling of the chromatin proteome reveals system-wide responses to replication inhibitionGuennadi A Khoudoli
Wellcome Trust Centre for Gene Regulation and Expression, University of Dundee, Dundee DD1 5EH, United Kingdom
Curr Biol 18:838-43. 2008.... 
Finding an image in a haystack: the case for public image repositoriesJason R Swedlow
Wellcome Trust Centre for Gene Regulation and Expression, College of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK
Nat Cell Biol 13:183. 2011..Image repositories are growing. Their potential impact is huge; they require support and proper funding...- Open source bioimage informatics for cell biologyJason R Swedlow
Wellcome Trust Centre for Gene Regulation and Expression, College of Life Sciences, University of Dundee, Dundee, Scotland DD1 5EH, UK
Trends Cell Biol 19:656-60. 2009.... - Bioimage informatics for experimental biologyJason R Swedlow
Wellcome Trust Centre for Gene Regulation and Expression, University of Dundee, Dundee DD1 5EH, Scotland, UK
Annu Rev Biophys 38:327-46. 2009..In this article we present the recent efforts by the bioimage informatics community to tackle these challenges, and discuss our own vision for future development of bioimage informatics solutions... 
Modelling data across labs, genomes, space and timeJason R Swedlow
Division of Gene Regulation and Expression, Wellcome Trust Biocentre, Faculty of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, UK
Nat Cell Biol 8:1190-4. 2006..Here, we use imaging applications to illustrate the purpose of the various implementations of data specifications and the requirement for open, standardized, data formats to facilitate the sharing of critical digital data and metadata...- OMERO: flexible, model-driven data management for experimental biologyChris Allan
Wellcome Trust Centre for Gene Regulation and Expression, College of Life Sciences, University of Dundee, Dundee, Scotland, UK
Nat Methods 9:245-53. 2012..OMERO's design and flexibility have enabled its use for light-microscopy, high-content-screening, electron-microscopy and even non-image-genotype data. OMERO is open-source software, available at http://openmicroscopy.org/... - Sds22 regulates aurora B activity and microtubule-kinetochore interactions at mitosisMarkus Posch
Wellcome Trust Centre for Gene Regulation and Expression, University of Dundee, Dundee DD1 5EH, Scotland, UK
J Cell Biol 191:61-74. 2010..Sds22 regulates PP1 targeting to the kinetochore, accumulation of phospho-aurora B, and force generation at the kinetochore-microtubule interface... - Phosphorylation regulates the dynamic interaction of RCC1 with chromosomes during mitosisJames R A Hutchins
Biomedical Research Centre, Ninewells Hospital and Medical School, University of Dundee, Dundee, DD1 9SY, Scotland, United Kingdom
Curr Biol 14:1099-104. 2004..This mechanism may be important for the localized generation of Ran-GTP on chromatin after nuclear envelope breakdown and may play a role in the coordination of progression through mitosis... - Bod1, a novel kinetochore protein required for chromosome biorientationIain M Porter
Division of Gene Regulation and Expression, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, UK
J Cell Biol 179:187-97. 2007..Therefore, Bod1 is a novel kinetochore protein that is required for the detection or resolution of syntelic attachments in mitotic spindles... - Open tools for storage and management of quantitative image dataJoshua Moore
Division of Gene Regulation and Expression, College of Life Sciences, Wellcome Trust Biocentre, University of Dundee, Dundee, Scotland DD1 5EH, United Kingdom
Methods Cell Biol 85:555-70. 2008..Together these systems provide a suite of tools for large-scale quantitative imaging that is now commonly used throughout cell and developmental biology... - How to be a mitotic chromosomeSandra C Moser
Wellcome Trust Centre for Gene Regulation and Expression, College of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK
Chromosome Res 19:307-19. 2011..Current results suggest how these different activities might interact to achieve the familiar form of the mitotic chromosome... - A novel reporter of notch signalling indicates regulated and random Notch activation during vertebrate neurogenesisFilipe Vilas-Boas
Instituto de Medicina Molecular and Instituto de Histologia e Biologia do Desenvolvimento, Faculdade de Medicina da Universidade de Lisboa, Av Prof, Egas Moniz, 1649 028 Lisboa, Portugal
BMC Biol 9:58. 2011..An essential tool with which to investigate the role of Notch signalling on cell by cell basis is the development a faithful reporter of Notch activity... - Live cell imaging using wide-field microscopy and deconvolutionJason R Swedlow
Division of Gene Regulation and Expression, MSI WTB complex, University of Dundee, Dundee, Scotland
Cell Struct Funct 27:335-41. 2002..In this review, we discuss each of these steps, highlighting practical techniques developed by us and others... - Time-lapse imaging reveals dynamic relocalization of PP1gamma throughout the mammalian cell cycleLaura Trinkle-Mulcahy
Wellcome Trust Biocentre, University of Dundee, Dundee DD1 5EH, United Kingdom
Mol Biol Cell 14:107-17. 2003..The changing spatio-temporal distribution of PP1gamma revealed using the stable PP1 cell lines implicates it in multiple processes, including nucleolar function, the regulation of chromosome segregation and cytokinesis... - Mitotic mechanics: the auroras come into viewPaul D Andrews
Division of Gene Expression and Regulation, Wellcome Trust Biocentre, University of Dundee, Dundee DD1 5EH, Scotland, UK
Curr Opin Cell Biol 15:672-83. 2003..Recent work on both kinases has revealed functional links between Aurora kinase activity and the mechanics of cell division... - Measuring tubulin content in Toxoplasma gondii: a comparison of laser-scanning confocal and wide-field fluorescence microscopyJason R Swedlow
MSI WTB complex, University of Dundee, DD1 5EH Dundee, Scotland
Proc Natl Acad Sci U S A 99:2014-9. 2002.... - Aurora B regulates MCAK at the mitotic centromerePaul D Andrews
Division of Gene Regulation and Expression, Wellcome Trust Biocentre, University of Dundee, Dow Street, Dundee DD1 5EH, United Kingdom
Dev Cell 6:253-68. 2004..These results link Aurora B activity to MCAK function, with Aurora B regulating MCAK's activity and its localization at the centromere and kinetochore... - To 5D and beyond: quantitative fluorescence microscopy in the postgenomic eraPaul D Andrews
Division of Gene Regulation and Expression, MSI/WTB Complex, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland, UK
Traffic 3:29-36. 2002..We propose that analysis of these data requires querying tools based on relational databases and describe one such system... - Informatics and quantitative analysis in biological imagingJason R Swedlow
Division of Gene Regulation and Expression, Wellcome Trust Biocentre, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland
Science 300:100-2. 2003..With this design, OME provides a first step toward biological image informatics... - Quantitative fluorescence microscopy and image deconvolutionJason R Swedlow
Division of Gene Regulation and Expression, University of Dundee, Dundee, DD1 5EH, Scotland, United Kingdom
Methods Cell Biol 72:349-67. 2003 - Quantitative fluorescence microscopy and image deconvolutionJason R Swedlow
Division of Gene Regulation and Expression, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, United Kingdom
Methods Cell Biol 81:447-65. 2007 - The making of the mitotic chromosome: modern insights into classical questionsJason R Swedlow
Division of Gene Regulation and Expression, University of Dundee, DD1 5EH, Dundee, United Kingdom
Mol Cell 11:557-69. 2003..In this review, we discuss recent work that sheds new light on the molecular and structural dynamics of mitotic chromosomes... - Chromosome condensation: DNA compaction in real timeIain M Porter
Division of Gene Regulation and Expression, MSI/WTB Complex, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland, UK
Curr Biol 14:R554-6. 2004..Two new studies report observations of DNA compaction by eukaryotic and bacterial condensin molecules in real time using magnetic and optical trapping micromanipulation techniques... - Mitotic spindle orientation distinguishes stem cell and terminal modes of neuron production in the early spinal cordArwen C Wilcock
Division of Cell and Developmental Biology, Wellcome Trust Biocentre, College of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, UK
Development 134:1943-54. 2007.... - Cajal body dynamics and association with chromatin are ATP-dependentMelpomeni Platani
School of Life Sciences, Division of Gene Regulation and Expression, University of Dundee, Medical Sciences Institute/Wellcome Trust Biocentre, Dow Street, Dundee, DD1 5EH, Scotland
Nat Cell Biol 4:502-8. 2002..This behaviour is fundamentally different from the ATP-dependent mobility observed for chromatin and suggests that a novel mechanism governs CB, and possibly other, nuclear body dynamics...