Jason R Swedlow

Summary

Affiliation: University of Dundee
Country: UK

Publications

  1. pmc Bod1, a novel kinetochore protein required for chromosome biorientation
    Iain M Porter
    Division of Gene Regulation and Expression, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, UK
    J Cell Biol 179:187-97. 2007
  2. pmc OMERO: flexible, model-driven data management for experimental biology
    Chris Allan
    Wellcome Trust Centre for Gene Regulation and Expression, College of Life Sciences, University of Dundee, Dundee, Scotland, UK
    Nat Methods 9:245-53. 2012
  3. pmc Sds22 regulates aurora B activity and microtubule-kinetochore interactions at mitosis
    Markus Posch
    Wellcome Trust Centre for Gene Regulation and Expression, University of Dundee, Dundee DD1 5EH, Scotland, UK
    J Cell Biol 191:61-74. 2010
  4. pmc Innovation in biological microscopy: current status and future directions
    Jason R Swedlow
    Wellcome Trust Centre for Gene Regulation and Expression, College of Life Sciences, University of Dundee, Dundee, Scotland, UK
    Bioessays 34:333-40. 2012
  5. pmc The Open Microscopy Environment (OME) Data Model and XML file: open tools for informatics and quantitative analysis in biological imaging
    Ilya G Goldberg
    Laboratory of Genetics National Institute on Aging, National Institutes of Health, 333 Cassell Drive, Baltimore, MD 21224, USA
    Genome Biol 6:R47. 2005
  6. pmc Bioimage informatics for experimental biology
    Jason R Swedlow
    Wellcome Trust Centre for Gene Regulation and Expression, University of Dundee, Dundee DD1 5EH, Scotland, UK
    Annu Rev Biophys 38:327-46. 2009
  7. ncbi request reprint Modelling data across labs, genomes, space and time
    Jason R Swedlow
    Division of Gene Regulation and Expression, Wellcome Trust Biocentre, Faculty of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, UK
    Nat Cell Biol 8:1190-4. 2006
  8. pmc Open source bioimage informatics for cell biology
    Jason R Swedlow
    Wellcome Trust Centre for Gene Regulation and Expression, College of Life Sciences, University of Dundee, Dundee, Scotland DD1 5EH, UK
    Trends Cell Biol 19:656-60. 2009
  9. doi request reprint Finding an image in a haystack: the case for public image repositories
    Jason R Swedlow
    Wellcome Trust Centre for Gene Regulation and Expression, College of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK
    Nat Cell Biol 13:183. 2011
  10. pmc Temporal profiling of the chromatin proteome reveals system-wide responses to replication inhibition
    Guennadi A Khoudoli
    Wellcome Trust Centre for Gene Regulation and Expression, University of Dundee, Dundee DD1 5EH, United Kingdom
    Curr Biol 18:838-43. 2008

Collaborators

Detail Information

Publications34

  1. pmc Bod1, a novel kinetochore protein required for chromosome biorientation
    Iain M Porter
    Division of Gene Regulation and Expression, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, UK
    J Cell Biol 179:187-97. 2007
    ..Therefore, Bod1 is a novel kinetochore protein that is required for the detection or resolution of syntelic attachments in mitotic spindles...
  2. pmc OMERO: flexible, model-driven data management for experimental biology
    Chris Allan
    Wellcome Trust Centre for Gene Regulation and Expression, College of Life Sciences, University of Dundee, Dundee, Scotland, UK
    Nat Methods 9:245-53. 2012
    ..OMERO's design and flexibility have enabled its use for light-microscopy, high-content-screening, electron-microscopy and even non-image-genotype data. OMERO is open-source software, available at http://openmicroscopy.org/...
  3. pmc Sds22 regulates aurora B activity and microtubule-kinetochore interactions at mitosis
    Markus Posch
    Wellcome Trust Centre for Gene Regulation and Expression, University of Dundee, Dundee DD1 5EH, Scotland, UK
    J Cell Biol 191:61-74. 2010
    ..Sds22 regulates PP1 targeting to the kinetochore, accumulation of phospho-aurora B, and force generation at the kinetochore-microtubule interface...
  4. pmc Innovation in biological microscopy: current status and future directions
    Jason R Swedlow
    Wellcome Trust Centre for Gene Regulation and Expression, College of Life Sciences, University of Dundee, Dundee, Scotland, UK
    Bioessays 34:333-40. 2012
    ..As these and more new technologies appear, the challenges of delivering them to the community grows as well. I discuss some of these challenges, and the examples where openly shared technology have made an impact on the field...
  5. pmc The Open Microscopy Environment (OME) Data Model and XML file: open tools for informatics and quantitative analysis in biological imaging
    Ilya G Goldberg
    Laboratory of Genetics National Institute on Aging, National Institutes of Health, 333 Cassell Drive, Baltimore, MD 21224, USA
    Genome Biol 6:R47. 2005
    ..The OME Data Model, expressed in Extensible Markup Language (XML) and realized in a traditional database, is both extensible and self-describing, allowing it to meet emerging imaging and analysis needs...
  6. pmc Bioimage informatics for experimental biology
    Jason R Swedlow
    Wellcome Trust Centre for Gene Regulation and Expression, University of Dundee, Dundee DD1 5EH, Scotland, UK
    Annu Rev Biophys 38:327-46. 2009
    ..In this article we present the recent efforts by the bioimage informatics community to tackle these challenges, and discuss our own vision for future development of bioimage informatics solutions...
  7. ncbi request reprint Modelling data across labs, genomes, space and time
    Jason R Swedlow
    Division of Gene Regulation and Expression, Wellcome Trust Biocentre, Faculty of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, UK
    Nat Cell Biol 8:1190-4. 2006
    ..Here, we use imaging applications to illustrate the purpose of the various implementations of data specifications and the requirement for open, standardized, data formats to facilitate the sharing of critical digital data and metadata...
  8. pmc Open source bioimage informatics for cell biology
    Jason R Swedlow
    Wellcome Trust Centre for Gene Regulation and Expression, College of Life Sciences, University of Dundee, Dundee, Scotland DD1 5EH, UK
    Trends Cell Biol 19:656-60. 2009
    ....
  9. doi request reprint Finding an image in a haystack: the case for public image repositories
    Jason R Swedlow
    Wellcome Trust Centre for Gene Regulation and Expression, College of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK
    Nat Cell Biol 13:183. 2011
    ..Image repositories are growing. Their potential impact is huge; they require support and proper funding...
  10. pmc Temporal profiling of the chromatin proteome reveals system-wide responses to replication inhibition
    Guennadi A Khoudoli
    Wellcome Trust Centre for Gene Regulation and Expression, University of Dundee, Dundee DD1 5EH, United Kingdom
    Curr Biol 18:838-43. 2008
    ....
  11. ncbi request reprint Phosphorylation regulates the dynamic interaction of RCC1 with chromosomes during mitosis
    James R A Hutchins
    Biomedical Research Centre, Ninewells Hospital and Medical School, University of Dundee, Dundee, DD1 9SY, Scotland, United Kingdom
    Curr Biol 14:1099-104. 2004
    ..This mechanism may be important for the localized generation of Ran-GTP on chromatin after nuclear envelope breakdown and may play a role in the coordination of progression through mitosis...
  12. ncbi request reprint Mitotic mechanics: the auroras come into view
    Paul D Andrews
    Division of Gene Expression and Regulation, Wellcome Trust Biocentre, University of Dundee, Dundee DD1 5EH, Scotland, UK
    Curr Opin Cell Biol 15:672-83. 2003
    ..Recent work on both kinases has revealed functional links between Aurora kinase activity and the mechanics of cell division...
  13. ncbi request reprint Aurora B regulates MCAK at the mitotic centromere
    Paul D Andrews
    Division of Gene Regulation and Expression, Wellcome Trust Biocentre, University of Dundee, Dow Street, Dundee DD1 5EH, United Kingdom
    Dev Cell 6:253-68. 2004
    ..These results link Aurora B activity to MCAK function, with Aurora B regulating MCAK's activity and its localization at the centromere and kinetochore...
  14. ncbi request reprint Chromosome condensation: DNA compaction in real time
    Iain M Porter
    Division of Gene Regulation and Expression, MSI WTB complex, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland, UK
    Curr Biol 14:R554-6. 2004
    ..Two new studies report observations of DNA compaction by eukaryotic and bacterial condensin molecules in real time using magnetic and optical trapping micromanipulation techniques...
  15. pmc Bod1 regulates protein phosphatase 2A at mitotic kinetochores
    Iain M Porter
    Centre for Gene Regulation and Expression, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK
    Nat Commun 4:2677. 2013
    ..Bod1, Ensa and Arpp-19 define a family of specific PP2A inhibitors that regulate specific PP2A holoenzymes at distinct locations and points in the cell cycle. ..
  16. ncbi request reprint Human CLASP1 is an outer kinetochore component that regulates spindle microtubule dynamics
    Helder Maiato
    Chromosome Structure Group, Wellcome Trust Centre for Cell Biology, Institute of Cell and Molecular Biology, University of Edinburgh, Swann Building, King s Buildings, Mayfield Road, EH9 3JR, Scotland, Edinburgh, United Kingdom
    Cell 113:891-904. 2003
    ..Our data suggest that CLASP1 is required at kinetochores for attached microtubules to exhibit normal dynamic behavior...
  17. pmc How to be a mitotic chromosome
    Sandra C Moser
    Wellcome Trust Centre for Gene Regulation and Expression, College of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK
    Chromosome Res 19:307-19. 2011
    ..Current results suggest how these different activities might interact to achieve the familiar form of the mitotic chromosome...
  18. pmc PHD1 links cell-cycle progression to oxygen sensing through hydroxylation of the centrosomal protein Cep192
    Sandra C Moser
    Centre for Gene Regulation and Expression, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK
    Dev Cell 26:381-92. 2013
    ..By modulating Cep192 levels, PHD1 thereby affects the processes of centriole duplication and centrosome maturation and contributes to the regulation of cell-cycle progression. ..
  19. ncbi request reprint Open tools for storage and management of quantitative image data
    Joshua Moore
    Division of Gene Regulation and Expression, College of Life Sciences, Wellcome Trust Biocentre, University of Dundee, Dundee, Scotland DD1 5EH, United Kingdom
    Methods Cell Biol 85:555-70. 2008
    ..Together these systems provide a suite of tools for large-scale quantitative imaging that is now commonly used throughout cell and developmental biology...
  20. pmc ELYS/MEL-28 chromatin association coordinates nuclear pore complex assembly and replication licensing
    Peter J Gillespie
    Division of Gene Regulation and Expression, College of Life Sciences, Wellcome Trust Biocentre, University of Dundee, Dundee DD1 5EH, Scotland, United Kingdom
    Curr Biol 17:1657-62. 2007
    ..Because nuclear assembly is required to shut down licensing prior to entry into S phase, our results suggest a mechanism by which these two early cell-cycle events are coordinated with one another...
  21. pmc The adenomatous polyposis coli protein contributes to normal compaction of mitotic chromatin
    Dina Dikovskaya
    Cell and Developmental Biology, University of Dundee, Dundee, Scotland, United Kingdom
    PLoS ONE 7:e38102. 2012
    ..Both were decreased on chromatin in APC-depleted extract; in addition, the kinetics of association of Set-a with chromatin was altered in the absence of APC...
  22. pmc Informatics and quantitative analysis in biological imaging
    Jason R Swedlow
    Division of Gene Regulation and Expression, Wellcome Trust Biocentre, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland
    Science 300:100-2. 2003
    ..With this design, OME provides a first step toward biological image informatics...
  23. doi request reprint Quantitative fluorescence microscopy and image deconvolution
    Jason R Swedlow
    Division of Gene Regulation and Expression, College of Life Sciences, University of Dundee, Dundee, Scotland, United Kingdom
    Methods Cell Biol 114:407-26. 2013
    ..Restoration algorithms determine an object that, when convolved with the point-spread function of the microscope, could produce the image data. The advantages and disadvantages of these methods are discussed...
  24. pmc A novel reporter of notch signalling indicates regulated and random Notch activation during vertebrate neurogenesis
    Filipe Vilas-Boas
    Instituto de Medicina Molecular and Instituto de Histologia e Biologia do Desenvolvimento, Faculdade de Medicina da Universidade de Lisboa, Av Prof, Egas Moniz, 1649 028 Lisboa, Portugal
    BMC Biol 9:58. 2011
    ..An essential tool with which to investigate the role of Notch signalling on cell by cell basis is the development a faithful reporter of Notch activity...
  25. pmc Time-lapse imaging reveals dynamic relocalization of PP1gamma throughout the mammalian cell cycle
    Laura Trinkle-Mulcahy
    Wellcome Trust Biocentre, University of Dundee, Dundee DD1 5EH, United Kingdom
    Mol Biol Cell 14:107-17. 2003
    ..The changing spatio-temporal distribution of PP1gamma revealed using the stable PP1 cell lines implicates it in multiple processes, including nucleolar function, the regulation of chromosome segregation and cytokinesis...
  26. pmc Measuring tubulin content in Toxoplasma gondii: a comparison of laser-scanning confocal and wide-field fluorescence microscopy
    Jason R Swedlow
    MSI WTB complex, University of Dundee, DD1 5EH Dundee, Scotland
    Proc Natl Acad Sci U S A 99:2014-9. 2002
    ....
  27. ncbi request reprint The making of the mitotic chromosome: modern insights into classical questions
    Jason R Swedlow
    Division of Gene Regulation and Expression, University of Dundee, DD1 5EH, Dundee, United Kingdom
    Mol Cell 11:557-69. 2003
    ..In this review, we discuss recent work that sheds new light on the molecular and structural dynamics of mitotic chromosomes...
  28. ncbi request reprint Quantitative fluorescence microscopy and image deconvolution
    Jason R Swedlow
    Division of Gene Regulation and Expression, University of Dundee, Dundee, DD1 5EH, Scotland, United Kingdom
    Methods Cell Biol 72:349-67. 2003
  29. ncbi request reprint Live cell imaging using wide-field microscopy and deconvolution
    Jason R Swedlow
    Division of Gene Regulation and Expression, MSI WTB complex, University of Dundee, Dundee, Scotland
    Cell Struct Funct 27:335-41. 2002
    ..In this review, we discuss each of these steps, highlighting practical techniques developed by us and others...
  30. pmc Phosphorylated DegU manipulates cell fate differentiation in the Bacillus subtilis biofilm
    Victoria L Marlow
    Division of Molecular Microbiology, College of Life Sciences, University of Dundee, Dundee, United Kingdom
    J Bacteriol 196:16-27. 2014
    ..Subsequent experimental analysis led us to conclude that DegU∼P functions to increase the level of Spo0A∼P, driving cell fate differentiation toward the terminal developmental process of sporulation. ..
  31. ncbi request reprint Mitotic spindle orientation distinguishes stem cell and terminal modes of neuron production in the early spinal cord
    Arwen C Wilcock
    Division of Cell and Developmental Biology, Wellcome Trust Biocentre, College of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, UK
    Development 134:1943-54. 2007
    ....
  32. ncbi request reprint Quantitative fluorescence microscopy and image deconvolution
    Jason R Swedlow
    Division of Gene Regulation and Expression, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, United Kingdom
    Methods Cell Biol 81:447-65. 2007
  33. ncbi request reprint Cajal body dynamics and association with chromatin are ATP-dependent
    Melpomeni Platani
    School of Life Sciences, Division of Gene Regulation and Expression, University of Dundee, Medical Sciences Institute Wellcome Trust Biocentre, Dow Street, Dundee, DD1 5EH, Scotland
    Nat Cell Biol 4:502-8. 2002
    ..This behaviour is fundamentally different from the ATP-dependent mobility observed for chromatin and suggests that a novel mechanism governs CB, and possibly other, nuclear body dynamics...
  34. ncbi request reprint To 5D and beyond: quantitative fluorescence microscopy in the postgenomic era
    Paul D Andrews
    Division of Gene Regulation and Expression, MSI WTB complex, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland, UK
    Traffic 3:29-36. 2002
    ..We propose that analysis of these data requires querying tools based on relational databases and describe one such system...