Robert Sutton

Summary

Affiliation: University of Liverpool
Country: UK

Publications

  1. doi request reprint Pancreatitis and calcium signalling: report of an international workshop
    Robert Sutton
    Division of Surgery and Oncology, MRC Group, University of Liverpool, Liverpool, UK
    Pancreas 36:e1-14. 2008
  2. doi request reprint Reactive oxygen species induced by bile acid induce apoptosis and protect against necrosis in pancreatic acinar cells
    David M Booth
    Physiological Laboratory, University of Liverpool, National Institute for Health Research Pancreas Biomedical Research Unit, Royal Liverpool University Hospital, Liverpool
    Gastroenterology 140:2116-25. 2011
  3. pmc Cholecystokinin-58 and cholecystokinin-8 exhibit similar actions on calcium signaling, zymogen secretion, and cell fate in murine pancreatic acinar cells
    David N Criddle
    Department of Physiology, University of Liverpool, UK
    Am J Physiol Gastrointest Liver Physiol 297:G1085-92. 2009
  4. doi request reprint Preoperative platelet-lymphocyte ratio is an independent significant prognostic marker in resected pancreatic ductal adenocarcinoma
    Richard A Smith
    Division of Surgery and Oncology, School of Cancer Studies, Royal Liverpool University Hospital, Liverpool, UK
    Am J Surg 197:466-72. 2009
  5. doi request reprint Direct activation of cytosolic Ca2+ signaling and enzyme secretion by cholecystokinin in human pancreatic acinar cells
    John A Murphy
    Physiological Laboratory, Medical Research Council Secretory Control Research Group, University of Liverpool, Liverpool, United Kingdom
    Gastroenterology 135:632-41. 2008
  6. doi request reprint A preoperative prognostic score for resected pancreatic and periampullary neuroendocrine tumours
    Nicole Sakka
    Division of Surgery and Oncology, School of Cancer Studies, University of Liverpool, Liverpool, UK
    Pancreatology 9:670-6. 2009
  7. ncbi request reprint Role of Ca2+ in pancreatic cell death induced by alcohol metabolites
    David N Criddle
    MRC Group, Physiological Laboratory, University of Liverpool, Liverpool, UK
    J Gastroenterol Hepatol 21:S14-7. 2006
  8. pmc Calcium and reactive oxygen species in acute pancreatitis: friend or foe?
    David M Booth
    Department of Cellular and Molecular Physiology, Institute of Translational Medicine, Faculty of Health and Life Sciences, University of Liverpool, Liverpool, United Kingdom
    Antioxid Redox Signal 15:2683-98. 2011
  9. doi request reprint Prognosis of resected ampullary adenocarcinoma by preoperative serum CA19-9 levels and platelet-lymphocyte ratio
    Richard A Smith
    Division of Surgery and Oncology, School of Cancer Studies, Royal Liverpool University Hospital, 5th Floor UCD Building, Daulby St, Liverpool, L69 3GA, UK
    J Gastrointest Surg 12:1422-8. 2008
  10. ncbi request reprint Fatty acid ethyl esters cause pancreatic calcium toxicity via inositol trisphosphate receptors and loss of ATP synthesis
    David N Criddle
    Medical Research Council Secretory Control Research Group, Physiological Laboratory, University of Liverpool, Liverpool, United Kingdom
    Gastroenterology 130:781-93. 2006

Collaborators

Detail Information

Publications32

  1. doi request reprint Pancreatitis and calcium signalling: report of an international workshop
    Robert Sutton
    Division of Surgery and Oncology, MRC Group, University of Liverpool, Liverpool, UK
    Pancreas 36:e1-14. 2008
    ..The publication of these proceedings is intended to provide a platform for enhancing research and therapeutic development for acute pancreatitis...
  2. doi request reprint Reactive oxygen species induced by bile acid induce apoptosis and protect against necrosis in pancreatic acinar cells
    David M Booth
    Physiological Laboratory, University of Liverpool, National Institute for Health Research Pancreas Biomedical Research Unit, Royal Liverpool University Hospital, Liverpool
    Gastroenterology 140:2116-25. 2011
    ..Oxidative stress is implicated in the pathogenesis of pancreatitis, but clinical trials of antioxidants have produced conflicting results. We examined the role of intracellular reactive oxygen species (ROS) in pancreatic acinar cell injury...
  3. pmc Cholecystokinin-58 and cholecystokinin-8 exhibit similar actions on calcium signaling, zymogen secretion, and cell fate in murine pancreatic acinar cells
    David N Criddle
    Department of Physiology, University of Liverpool, UK
    Am J Physiol Gastrointest Liver Physiol 297:G1085-92. 2009
    ..Our data strengthen the argument that CCK-58 is an important physiological form of this gastrointestinal hormone...
  4. doi request reprint Preoperative platelet-lymphocyte ratio is an independent significant prognostic marker in resected pancreatic ductal adenocarcinoma
    Richard A Smith
    Division of Surgery and Oncology, School of Cancer Studies, Royal Liverpool University Hospital, Liverpool, UK
    Am J Surg 197:466-72. 2009
    ..The objective of this study was to investigate whether the preoperative platelet-lymphocyte (P/L) ratio represents a significant prognostic index in resected pancreatic ductal adenocarcinoma...
  5. doi request reprint Direct activation of cytosolic Ca2+ signaling and enzyme secretion by cholecystokinin in human pancreatic acinar cells
    John A Murphy
    Physiological Laboratory, Medical Research Council Secretory Control Research Group, University of Liverpool, Liverpool, United Kingdom
    Gastroenterology 135:632-41. 2008
    ..We tested whether CCK (CCK-8 and human CCK-58) can act directly on human pancreatic acinar cells...
  6. doi request reprint A preoperative prognostic score for resected pancreatic and periampullary neuroendocrine tumours
    Nicole Sakka
    Division of Surgery and Oncology, School of Cancer Studies, University of Liverpool, Liverpool, UK
    Pancreatology 9:670-6. 2009
    ..To identify potential preoperative prognostic factors in resected pancreatic and periampullary neuroendocrine tumours...
  7. ncbi request reprint Role of Ca2+ in pancreatic cell death induced by alcohol metabolites
    David N Criddle
    MRC Group, Physiological Laboratory, University of Liverpool, Liverpool, UK
    J Gastroenterol Hepatol 21:S14-7. 2006
    ..The FA-induced necrosis is Ca(2+)-dependent. The destructive sustained Ca(2+) signals are due to inhibition of mitochondrial function with failure of ATP generation...
  8. pmc Calcium and reactive oxygen species in acute pancreatitis: friend or foe?
    David M Booth
    Department of Cellular and Molecular Physiology, Institute of Translational Medicine, Faculty of Health and Life Sciences, University of Liverpool, Liverpool, United Kingdom
    Antioxid Redox Signal 15:2683-98. 2011
    ..Disruption of Ca(2+) homeostasis in response to precipitants of AP leads to loss of mitochondrial integrity and cellular necrosis...
  9. doi request reprint Prognosis of resected ampullary adenocarcinoma by preoperative serum CA19-9 levels and platelet-lymphocyte ratio
    Richard A Smith
    Division of Surgery and Oncology, School of Cancer Studies, Royal Liverpool University Hospital, 5th Floor UCD Building, Daulby St, Liverpool, L69 3GA, UK
    J Gastrointest Surg 12:1422-8. 2008
    ..The objective of this study was to evaluate whether preoperative CA19-9 levels and the platelet-lymphocyte ratio (PLR) might reflect prognostic indices for resected ampullary adenocarcinoma...
  10. ncbi request reprint Fatty acid ethyl esters cause pancreatic calcium toxicity via inositol trisphosphate receptors and loss of ATP synthesis
    David N Criddle
    Medical Research Council Secretory Control Research Group, Physiological Laboratory, University of Liverpool, Liverpool, United Kingdom
    Gastroenterology 130:781-93. 2006
    ..Fatty acid ethyl esters are ethanol metabolites inducing sustained, toxic elevations of the acinar cytosolic free calcium ion concentration ([Ca(2+)](C)) implicated in pancreatitis. We sought to define the mechanisms of this elevation...
  11. doi request reprint Classification of R1 resections for pancreatic cancer: the prognostic relevance of tumour involvement within 1 mm of a resection margin
    Fiona Campbell
    Department of Pathology, School of Cancer Studies, University of Liverpool, Royal Liverpool University Hospital, 5th Floor Duncan Building, Daulby Street, Liverpool L69 3GA, UK
    Histopathology 55:277-83. 2009
    ....
  12. ncbi request reprint Failure of calcium microdomain generation and pathological consequences
    Ole H Petersen
    MRC Group, The Physiological Laboratory, University of Liverpool, Crown Street, Liverpool, UK
    Cell Calcium 40:593-600. 2006
    ..Because of the abolition of ATP-dependent Ca(2+) pump activity, all intracellular Ca(2+) concentration gradients disappear and the most important part of the normal regulatory machinery is thereby destroyed. The end stage is necrosis...
  13. doi request reprint Partial pancreatic resection for pancreatic malignancy is associated with sustained pancreatic exocrine failure and reduced quality of life: a prospective study
    Christopher M Halloran
    Department of Molecular and Clinical Cancer Medicine, University of Liverpool, and National Institute for Pancreas Biomedical Research Unit, Liverpool, UK
    Pancreatology 11:535-45. 2011
    ..This study examined the coefficient of fat absorption (CFA), symptoms, quality of life (QoL) and the accuracy of faecal elastase-1 (FE-1) measurement to predict PEI...
  14. ncbi request reprint The pancreas misled: signals to pancreatitis
    David N Criddle
    MRC Group, Physiological Laboratory, University of Liverpool, Liverpool, UK
    Pancreatology 7:436-46. 2007
    ..While recent discoveries have increased insight and suggest prophylaxis or treatment targets, more work is required to define the mechanisms and interactions of cell signalling pathways in the pathogenesis of pancreatitis...
  15. ncbi request reprint Acute pancreatitis and organ failure: pathophysiology, natural history, and management strategies
    Michael G T Raraty
    Department of Surgery, University of Liverpool, 5th Floor, UCD Building, Royal Liverpool University Hospital, Daulby Street, Liverpool L69 3GA, UK
    Curr Gastroenterol Rep 6:99-103. 2004
    ..Although a number of techniques to accomplish this end have been described, minimally invasive techniques are gaining in popularity...
  16. ncbi request reprint Caspase-8-mediated apoptosis induced by oxidative stress is independent of the intrinsic pathway and dependent on cathepsins
    Heidi K Baumgartner
    The Physiological Laboratory, Biomedical Sciences, Liverpool University, Crown Street, Liverpool, UK
    Am J Physiol Gastrointest Liver Physiol 293:G296-307. 2007
    ....
  17. ncbi request reprint Menadione-induced reactive oxygen species generation via redox cycling promotes apoptosis of murine pancreatic acinar cells
    David N Criddle
    MRC Secretory Research Group, Department of Physiology and Division of Surgery and Oncology, University of Liverpool, Liverpool L69 3BX, United Kingdom
    J Biol Chem 281:40485-92. 2006
    ..Two-electron detoxifying enzymes such as NAD(P)H:quinone oxidoreductase, which are elevated in pancreatitis, may provide protection against excessive ROS and exert an important role in determining acinar cell fate...
  18. ncbi request reprint Ca2+ signalling and pancreatitis: effects of alcohol, bile and coffee
    Ole H Petersen
    MRC Group, Physiological Laboratory and Division of Surgery and Oncology, University of Liverpool, Liverpool L69 3BX, UK
    Trends Pharmacol Sci 27:113-20. 2006
    ..These abnormal Ca2+ signals, which can be inhibited by caffeine, explain how excessive alcohol intake and biliary disease cause acute pancreatitis, an often-fatal human disease in which the pancreas digests itself and its surroundings...
  19. ncbi request reprint Signal transduction, calcium and acute pancreatitis
    Robert Sutton
    Department of Surgery, University of Liverpool, 5th Floor UCD Block, Royal Liverpool University Hospital, Daulby Street, Liverpool L69 3GA, UK
    Pancreatology 3:497-505. 2003
    ..This review outlines current understanding of signal transduction in the pancreas, and its application to the pathophysiology of acute pancreatitis...
  20. pmc Randomised Phase I/II trial assessing the safety and efficacy of radiolabelled anti-carcinoembryonic antigen I(131) KAb201 antibodies given intra-arterially or intravenously in patients with unresectable pancreatic adenocarcinoma
    Asma Sultana
    Division of Surgery and Oncology, University of Liverpool, Liverpool, UK
    BMC Cancer 9:66. 2009
    ..This study aimed to evaluate the safety and tolerability of KAb201, an anti-carcinoembryonic antigen monoclonal antibody, labelled with I(131) in pancreatic cancer (ISRCTN 16857581)...
  21. pmc Serum cytokine biomarker panels for discriminating pancreatic cancer from benign pancreatic disease
    Victoria E Shaw
    NIHR Liverpool Pancreas Biomedical Research Unit, Royal Liverpool and Broadgreen University Hospital NHS Trust, Department of Molecular and Clinical Cancer Medicine, University of Liverpool, Liverpool L69 3GA, UK
    Mol Cancer 13:114. 2014
    ..We investigated whether combinations of serum cytokines, used with logistic disease predictor models, could facilitate the detection of pancreatic ductal adenocarcinoma (PDAC)...
  22. ncbi request reprint Fatty acid ethyl ester synthase inhibition ameliorates ethanol-induced Ca2+-dependent mitochondrial dysfunction and acute pancreatitis
    Wei Huang
    Department of Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Liverpool, Merseyside, UK NIHR Liverpool Pancreas Biomedical Research Unit, RLBUHT, Institute of Translational Medicine, University of Liverpool, Liverpool, Merseyside, UK Department of Integrated Traditional Chinese and Western Medicine, Sichuan Provincial Pancreatitis Centre, West China Hospital, Sichuan University, China
    Gut 63:1313-24. 2014
    ..This study investigated the relative importance of oxidative and non-oxidative pathways in mitochondrial dysfunction, pancreatic damage and development of alcoholic AP, and whether deleterious effects of NOME are preventable...
  23. pmc A mouse model of pathological small intestinal epithelial cell apoptosis and shedding induced by systemic administration of lipopolysaccharide
    Jonathan M Williams
    Department of Gastroenterology, Institute of Translational Medicine, University of Liverpool, Liverpool, L69 3GE, UK
    Dis Model Mech 6:1388-99. 2013
    ..This model will enable investigation of the importance and regulation of pathological IEC apoptosis and cell shedding in various diseases. ..
  24. doi request reprint Protective effects of fucoidan, a P- and L-selectin inhibitor, in murine acute pancreatitis
    Ana C S Carvalho
    From the Departments of Physiology and Pharmacology and Morphology, Institute of Biomedicine of Brazilian Semi arid, School of Medicine, Federal University of Ceara, Fortaleza, Ceara, Brazil and NIHR Pancreas Biomedical Research Unit and Department of Cellular and Molecular Physiology, Institute of Translational Medicine, University of Liverpool, Liverpool, UK
    Pancreas 43:82-7. 2014
    ..The objective of this study was to investigate the potential protective effects of fucoidan, an L- and P-selectin modulator, in 2 murine models of acute pancreatitis...
  25. doi request reprint The platelet-lymphocyte ratio improves the predictive value of serum CA19-9 levels in determining patient selection for staging laparoscopy in suspected periampullary cancer
    Richard A Smith
    Division of Surgery and Oncology, School of Cancer Studies, University of Liverpool, Liverpool, UK
    Surgery 143:658-66. 2008
    ....
  26. ncbi request reprint Prognostic potential of hepatocyte volume and cytokine expression in cirrhotic portal hypertension
    Saboor Khan
    Department of Surgery, University of Liverpool, Liverpool, UK
    J Gastroenterol Hepatol 20:1519-26. 2005
    ..We have examined the prognostic significance of hepatocyte volume (HV) and the expression of selected cytokines controlling liver repair and regeneration...
  27. doi request reprint The variable phenotype of the p.A16V mutation of cationic trypsinogen (PRSS1) in pancreatitis families
    Christopher J Grocock
    School of Cancer Studies, University of Liverpool, UCD Building, Daulby Street, Liverpool, UK
    Gut 59:357-63. 2010
    ..To characterise the phenotypes associated with the p.A16V mutation of PRSS1...
  28. doi request reprint Effect of atazanavir and ritonavir on the differentiation and adipokine secretion of human subcutaneous and omental preadipocytes
    Simon P Jones
    Department of Pharmacology and Therapeutics, The University of Liverpool, Liverpool, UK
    AIDS 22:1293-8. 2008
    ....
  29. ncbi request reprint Loss of heterozygosity on chromosome 17p predicts neoplastic progression in Barrett's esophagus
    Kevin Dolan
    University of Liverpool and Department of Surgery, Royal Liverpool University Hospital, Liverpool, UK
    J Gastroenterol Hepatol 18:683-9. 2003
    ..The aim of this prospective study was to determine if loss of heterozygosity analysis could identify patients with Barrett's esophagus at greatest risk of adenocarcinoma, for whom endoscopic surveillance is most appropriate...
  30. ncbi request reprint The role of adjuvant therapy for pancreatic cancer
    Conor J Magee
    Department of Surgery, University of Liverpool, 5th Floor UCD Building, Daulby Street, Liverpool, L69 3GA, UK
    Expert Opin Investig Drugs 11:87-107. 2002
    ..The results of large-scale randomised controlled trials to assess adjuvant therapies for pancreatic cancer demonstrate the great surgical and oncological progress that has been made over the past decade...
  31. pmc Bile acids induce calcium signals in mouse pancreatic acinar cells: implications for bile-induced pancreatic pathology
    Svetlana Voronina
    The Physiological Laboratory, The University of Liverpool, Crown Street, Liverpool L69 3BX, UK
    J Physiol 540:49-55. 2002
    ..The calcium releasing properties of bile acids suggest that calcium toxicity could be an important contributing factor in the bile acid-induced cellular damage...
  32. pmc Ethanol toxicity in pancreatic acinar cells: mediation by nonoxidative fatty acid metabolites
    David N Criddle
    Physiological Laboratory, Medical Research Council Secretory Control Research Group, University of Liverpool, Liverpool L69 3BX, United Kingdom
    Proc Natl Acad Sci U S A 101:10738-43. 2004
    ....