Alex J Sutton

Summary

Affiliation: University of Leicester
Country: UK

Publications

  1. ncbi request reprint Recent developments in meta-analysis
    Alexander J Sutton
    Department of Health Sciences, University of Leicester, Leicester LE1 7RH, UK
    Stat Med 27:625-50. 2008
  2. pmc Bivariate random-effects meta-analysis and the estimation of between-study correlation
    Richard D Riley
    Centre for Medical Statistics and Health Evaluation, School of Health Sciences, University of Liverpool, Shelley s Cottage, Brownlow Street, Liverpool, L69 3GS, UK
    BMC Med Res Methodol 7:3. 2007
  3. pmc Evidence synthesis as the key to more coherent and efficient research
    Alexander J Sutton
    Department of Health Sciences, University of Leicester, Leicester, UK
    BMC Med Res Methodol 9:29. 2009
  4. ncbi request reprint Evidence-based sample size calculations based upon updated meta-analysis
    Alexander J Sutton
    Department of Health Sciences, University of Leicester, Leicester, UK
    Stat Med 26:2479-500. 2007
  5. ncbi request reprint Integration of meta-analysis and economic decision modeling for evaluating diagnostic tests
    Alexander J Sutton
    Department of Health Sciences, Centre for Biostatistics and Genetic Epidemiology, University of Leicester, Leicester, England
    Med Decis Making 28:650-67. 2008
  6. ncbi request reprint A Bayesian approach to evaluating net clinical benefit allowed for parameter uncertainty
    Alexander J Sutton
    Department of Health Sciences, University of Leicester, 22 28 Princess Road West, Leicester LE1 6TP, United Kingdom
    J Clin Epidemiol 58:26-40. 2005
  7. ncbi request reprint Use of indirect and mixed treatment comparisons for technology assessment
    Alex Sutton
    Department of Health Sciences and NICE Decision Support Unit, University of Leicester, Leicester, UK
    Pharmacoeconomics 26:753-67. 2008
  8. doi request reprint An encouraging assessment of methods to inform priorities for updating systematic reviews
    Alex J Sutton
    Department of Health Sciences, University of Leicester, Leicester, UK
    J Clin Epidemiol 62:241-51. 2009
  9. ncbi request reprint Meta-analysis of individual- and aggregate-level data
    A J Sutton
    Department of Health Sciences, University of Leicester, Leicester, UK
    Stat Med 27:651-69. 2008
  10. ncbi request reprint Generalized synthesis of evidence and the threat of dissemination bias. the example of electronic fetal heart rate monitoring (EFM)
    Alexander J Sutton
    Department of Epidemiology and Public Health, University of Leicester, 22 28 Princess Road West, Leicester LE1 6TP, UK
    J Clin Epidemiol 55:1013-24. 2002

Detail Information

Publications75

  1. ncbi request reprint Recent developments in meta-analysis
    Alexander J Sutton
    Department of Health Sciences, University of Leicester, Leicester LE1 7RH, UK
    Stat Med 27:625-50. 2008
    ..We conclude the paper with some remarks on ongoing challenges and possible directions for the future...
  2. pmc Bivariate random-effects meta-analysis and the estimation of between-study correlation
    Richard D Riley
    Centre for Medical Statistics and Health Evaluation, School of Health Sciences, University of Liverpool, Shelley s Cottage, Brownlow Street, Liverpool, L69 3GS, UK
    BMC Med Res Methodol 7:3. 2007
    ..A multivariate random-effects meta-analysis must incorporate and estimate the between-study correlation (rhoB)...
  3. pmc Evidence synthesis as the key to more coherent and efficient research
    Alexander J Sutton
    Department of Health Sciences, University of Leicester, Leicester, UK
    BMC Med Res Methodol 9:29. 2009
    ..Systematic review and meta-analysis currently underpin much of evidence-based medicine. Such methodologies bring order to previous research, but future research planning remains relatively incoherent and inefficient...
  4. ncbi request reprint Evidence-based sample size calculations based upon updated meta-analysis
    Alexander J Sutton
    Department of Health Sciences, University of Leicester, Leicester, UK
    Stat Med 26:2479-500. 2007
    ..This raises issues regarding the appropriateness of the use of random effect models when designing and drawing inferences across a series of studies...
  5. ncbi request reprint Integration of meta-analysis and economic decision modeling for evaluating diagnostic tests
    Alexander J Sutton
    Department of Health Sciences, Centre for Biostatistics and Genetic Epidemiology, University of Leicester, Leicester, England
    Med Decis Making 28:650-67. 2008
    ..Setting policy to relate to a specific point may be much more difficult for studies with implicit thresholds...
  6. ncbi request reprint A Bayesian approach to evaluating net clinical benefit allowed for parameter uncertainty
    Alexander J Sutton
    Department of Health Sciences, University of Leicester, 22 28 Princess Road West, Leicester LE1 6TP, United Kingdom
    J Clin Epidemiol 58:26-40. 2005
    ..The potential benefits and harms of a treatment policy may differ between individuals. If these benefits and harms are not evaluated distinctly, and in a quantitative framework, transparency can be lost in the decision-making process...
  7. ncbi request reprint Use of indirect and mixed treatment comparisons for technology assessment
    Alex Sutton
    Department of Health Sciences and NICE Decision Support Unit, University of Leicester, Leicester, UK
    Pharmacoeconomics 26:753-67. 2008
    ....
  8. doi request reprint An encouraging assessment of methods to inform priorities for updating systematic reviews
    Alex J Sutton
    Department of Health Sciences, University of Leicester, Leicester, UK
    J Clin Epidemiol 62:241-51. 2009
    ..To consider the use of statistical methods that aim to prioritize the updating of a collection of systematic reviews based on preliminary literature searches...
  9. ncbi request reprint Meta-analysis of individual- and aggregate-level data
    A J Sutton
    Department of Health Sciences, University of Leicester, Leicester, UK
    Stat Med 27:651-69. 2008
    ..Using the same general approach, it would be possible to develop further 'tailor made' evidence synthesis models to synthesize all available evidence most effectively...
  10. ncbi request reprint Generalized synthesis of evidence and the threat of dissemination bias. the example of electronic fetal heart rate monitoring (EFM)
    Alexander J Sutton
    Department of Epidemiology and Public Health, University of Leicester, 22 28 Princess Road West, Leicester LE1 6TP, UK
    J Clin Epidemiol 55:1013-24. 2002
    ..Further research into methods to assess dissemination bias that are invariant to these factors is needed...
  11. pmc A case-control study to investigate the relation between low and moderate levels of physical activity and osteoarthritis of the knee using data collected as part of the Allied Dunbar National Fitness Survey
    A J Sutton
    Department of Epidemiology and Public Health, University of Leicester, 22 28 Princess Road West, Leicester LE1 6TP, UK
    Ann Rheum Dis 60:756-64. 2001
    ....
  12. ncbi request reprint Bayesian methods in meta-analysis and evidence synthesis
    A J Sutton
    Department of Epidemiology and Public Health, University of Leicester, UK
    Stat Methods Med Res 10:277-303. 2001
    ..The Bayesian methods discussed are illustrated by means of a meta-analysis examining the evidence relating to electronic fetal heart rate monitoring and perinatal mortality in which evidence is available from a variety of sources...
  13. ncbi request reprint Modelling publication bias in meta-analysis: a review
    A J Sutton
    Department of Epidemiology and Public Health, University of Leicester, 22 28 Princess Road West, Leicester LE1 6TP, UK
    Stat Methods Med Res 9:421-45. 2000
    ..It is hoped that this will raise awareness of such methods, and promote their use and development, as well as provide an agenda for future research...
  14. pmc Different strategies for screening and prevention of type 2 diabetes in adults: cost effectiveness analysis
    Clare L Gillies
    Centre for Biostatistics and Genetic Epidemiology, Department of Health Sciences, University of Leicester, Leicester LE1 7RH
    BMJ 336:1180-5. 2008
    ....
  15. pmc Use of Bayesian Multivariate Meta-Analysis to Estimate the HAQ for Mapping Onto the EQ-5D Questionnaire in Rheumatoid Arthritis
    Sylwia Bujkiewicz
    Biostatistics Research Group, Department of Health Sciences, University of Leicester, Leicester, UK Electronic address
    Value Health 17:109-15. 2014
    ..Therefore, alternative clinical outcomes, including surrogate end points, are increasingly being considered for use in evidence synthesis as part of economic evaluation...
  16. pmc Assessment of regression-based methods to adjust for publication bias through a comprehensive simulation study
    Santiago G Moreno
    Department of Health Sciences, University of Leicester, Leicester, UK
    BMC Med Res Methodol 9:2. 2009
    ..This issue potentially mean inappropriate conclusions are drawn from a meta-analysis. If meta-analysis is to be used to inform decision-making, a reliable way to adjust pooled estimates for potential funnel plot asymmetry is required...
  17. ncbi request reprint Sensitivity analyses allowed more appropriate and reliable meta-analysis conclusions for multiple outcomes when missing data was present
    Richard D Riley
    Centre for Biostatistics and Genetic Epidemiology, Department of Health Sciences, University of Leicester, Princess Road West, Leicester LE1 6TP, United Kingdom
    J Clin Epidemiol 57:911-24. 2004
    ..Dissemination bias, in how and what outcomes are reported or published, may be causing this incompleteness. This article illustrates these problems and presents possible sensitivity analyses to allow the most reliable conclusions...
  18. ncbi request reprint How vague is vague? A simulation study of the impact of the use of vague prior distributions in MCMC using WinBUGS
    Paul C Lambert
    Centre for Biostatistics and Genetic Epidemiology, Department of Health Sciences, University of Leicester, UK
    Stat Med 24:2401-28. 2005
    ..The choice of 'vague' prior distribution can lead to a marked variation in results, particularly in small studies. Sensitivity to the choice of prior distribution should always be assessed...
  19. ncbi request reprint A systematic review of systematic reviews and meta-analyses of animal experiments with guidelines for reporting
    Jaime L Peters
    Centre for Biostatistics and Genetic Epidemiology, Department of Health Sciences, University of Leicester, Leicester, UK
    J Environ Sci Health B 41:1245-58. 2006
    ..Further consideration of the use and methodological quality and reporting of such studies is needed...
  20. pmc Multivariate meta-analysis of mixed outcomes: a Bayesian approach
    Sylwia Bujkiewicz
    Biostatistics Research Group, Department of Health Sciences, University of Leicester, University Road, Leicester, LE1 7RH, U K
    Stat Med 32:3926-43. 2013
    ..We have applied this model to a motivating example in rheumatoid arthritis with the aim of incorporating all available evidence in the synthesis and potentially reducing uncertainty around the estimate of interest...
  21. pmc Development of a transparent interactive decision interrogator to facilitate the decision-making process in health care
    Sylwia Bujkiewicz
    Department of Health Sciences, University of Leicester, Leicester, UK
    Value Health 14:768-76. 2011
    ..Decisions about the use of new technologies in health care are often based on complex economic models. Decision makers frequently make informal judgments about evidence, uncertainty, and the assumptions that underpin these models...
  22. doi request reprint Interspecies extrapolation in environmental exposure standard setting: A Bayesian synthesis approach
    David R Jones
    Department of Health Sciences, Adrian Building, University of Leicester, Leicester, LE1 7RH, UK
    Regul Toxicol Pharmacol 53:217-25. 2009
    ..The methods are applied to evidence relating chlorinated by-products exposure to adverse reproductive health effects. The relative merits of various approaches are discussed, and developments and next steps are outlined...
  23. ncbi request reprint Performance of the trim and fill method in the presence of publication bias and between-study heterogeneity
    Jaime L Peters
    Department of Health Sciences, University of Leicester, Leicester LE1 7RH, U K
    Stat Med 26:4544-62. 2007
    ....
  24. doi request reprint Extending methods for investigating the relationship between treatment effect and baseline risk from pairwise meta-analysis to network meta-analysis
    Felix A Achana
    Department of Health Sciences, University of Leicester, Leicester LE1 7RH, U K
    Stat Med 32:752-71. 2013
    ..The results showed no evidence of baseline effect in the smoke alarm example, but the analgesics example shows that the adjustment can greatly reduce heterogeneity and improve overall model fit...
  25. ncbi request reprint Comparison of two methods to detect publication bias in meta-analysis
    Jaime L Peters
    Centre for Biostatistics and Genetic Epidemiology, Department of Health Sciences, University of Leicester, Leicester, England
    JAMA 295:676-80. 2006
    ..However, the performance of this test and the usual funnel plot have been challenged particularly when the summary estimate is the natural log of the odds ratio (lnOR)...
  26. ncbi request reprint The use of systematic reviews when designing studies
    Nicola J Cooper
    Centre for Biostatistics and Genetic Epidemiology, Department of Health Sciences, University of Leicester, Leicester, UK
    Clin Trials 2:260-4. 2005
    ..Our objective was to assess the use made of results of reviews in the designing of new studies...
  27. ncbi request reprint Addressing between-study heterogeneity and inconsistency in mixed treatment comparisons: Application to stroke prevention treatments in individuals with non-rheumatic atrial fibrillation
    Nicola J Cooper
    Department of Health Sciences, University of Leicester, Leicester, U K
    Stat Med 28:1861-81. 2009
    ..Although such an approach may adjust for inconsistencies in networks, as for standard meta-regression, the analysis will suffer from low power if the number of trials is small compared with the number of treatment comparators...
  28. ncbi request reprint Comprehensive decision analytical modelling in economic evaluation: a Bayesian approach
    Nicola J Cooper
    Department of Epidemiology and Public Health, University of Leicester, UK
    Health Econ 13:203-26. 2004
    ..The advantages of integrating the four stages outlined into one comprehensive decision analytical model, compared to the conventional 'two-stage' approach, are discussed...
  29. ncbi request reprint Contour-enhanced meta-analysis funnel plots help distinguish publication bias from other causes of asymmetry
    Jaime L Peters
    Department of Health Sciences, University of Leicester, Leicester, UK
    J Clin Epidemiol 61:991-6. 2008
    ..To present the contour-enhanced funnel plot as an aid to differentiating asymmetry due to publication bias from that due to other factors...
  30. ncbi request reprint Randomized trials with concurrent economic evaluations reported unrepresentatively large clinical effect sizes
    Simon Gilbody
    Department of Health Sciences, University of York, York YO10 5DD, UK
    J Clin Epidemiol 60:781-6. 2007
    ..To examine whether randomized economic evaluations report clinical effectiveness estimates that are unrepresentative of the totality of the research literature...
  31. ncbi request reprint Estimating the cost-effectiveness of an intervention in a clinical trial when partial cost information is available: a Bayesian approach
    Paul C Lambert
    Centre for Biostatistics and Genetic Epidemiology, Department of Health Sciences, University of Leicester, Leicester, UK
    Health Econ 17:67-81. 2008
    ..The models estimate the interrelationships between the four cost components and survival, and thus enable a predictive distribution for each missing cost item to be obtained...
  32. pmc Pharmacological and lifestyle interventions to prevent or delay type 2 diabetes in people with impaired glucose tolerance: systematic review and meta-analysis
    Clare L Gillies
    Centre for Biostatistics and Genetic Epidemiology, Department of Health Sciences, University of Leicester, Leicester LE1 7RH
    BMJ 334:299. 2007
    ..To quantify the effectiveness of pharmacological and lifestyle interventions to prevent or delay type 2 diabetes in people with impaired glucose tolerance...
  33. pmc Novel methods to deal with publication biases: secondary analysis of antidepressant trials in the FDA trial registry database and related journal publications
    Santiago G Moreno
    Department of Health Sciences, University of Leicester, Leicester LE1 7RH
    BMJ 339:b2981. 2009
    ..To assess the performance of novel contour enhanced funnel plots and a regression based adjustment method to detect and adjust for publication biases...
  34. doi request reprint Network meta-analysis to evaluate the effectiveness of interventions to increase the uptake of smoke alarms
    Nicola J Cooper
    Centre for Biostatistics and Genetic Epidemiology, Department of Health Sciences, University of Leicester, 22 28 Princess Road West, Leicester LE1 6TP, United Kingdom
    Epidemiol Rev 34:32-45. 2012
    ..69). Smoke alarm promotion programs should ensure they provide the combination of interventions most likely to be effective...
  35. ncbi request reprint Use of Bayesian Markov Chain Monte Carlo methods to model cost-of-illness data
    Nicola J Cooper
    Department of Epidemiology and Public Health, University of Leicester, United Kingdom
    Med Decis Making 23:38-53. 2003
    ..The NOAR database also includes information on various patient-level covariates...
  36. pmc Benefits and harms associated with hormone replacement therapy: clinical decision analysis
    Cosetta Minelli
    Centre for Biostatistics and Genetic Epidemiology, Department of Health Sciences, University of Leicester, Leicester LE1 6TP
    BMJ 328:371. 2004
    ..To evaluate harms and benefits associated with use of combined hormone replacement therapy (HRT) for five years in women with different baseline risks for breast cancer...
  37. doi request reprint Subintimal angioplasty: meta-analytical evidence of clinical utility
    M J Bown
    Department of Cardiovascular Sciences, University of Leicester, Leicester, UK
    Eur J Vasc Endovasc Surg 38:323-37. 2009
    ..The aim of this study was to determine accurate estimates of the success rate of subintimal angioplasty in terms of ability to recanalise occluded vessels, patency over time and limb salvage rates...
  38. ncbi request reprint Decision analytical economic modelling within a Bayesian framework: application to prophylactic antibiotics use for caesarean section
    N J Cooper
    Department of Epidemiology and Public Health, University of Leicester, Leicester, UK
    Stat Methods Med Res 11:491-512. 2002
    ....
  39. ncbi request reprint Use of evidence in economic decision models: practical issues and methodological challenges
    N J Cooper
    Department of Health Sciences, University of Leicester, Leicester, UK
    Health Econ 16:1277-86. 2007
    ..Gaps in the established methodology knowledge base are identified for future research...
  40. doi request reprint Systematic review and meta-analysis of mortality in crop protection product manufacturing workers
    D R Jones
    Department of Health Sciences, University of Leicester, University Road, Leicester LE1 7RH, UK
    Occup Environ Med 66:7-15. 2009
    ..The potential health effects of the manufacture and use of crop protection chemicals were investigated through systematic review and meta-analysis of studies of cohorts of workers in the crop protection product manufacturing industry...
  41. ncbi request reprint A comparison of summary patient-level covariates in meta-regression with individual patient data meta-analysis
    P C Lambert
    Department of Epidemiology and Public Health, University of Leicester, 22 28 Princess Road West, LE1 6TP, Leicester, UK
    J Clin Epidemiol 55:86-94. 2002
    ..To compare meta-analysis of summary study level data with the equivalent individual patient data (IPD) analysis when interest lies in identification of binary patient characteristics related to treatment efficacy...
  42. ncbi request reprint Consumption of mannan-binding lectin during abdominal aortic aneurysm repair
    M G A Norwood
    Department of Cardiovascular Sciences, University of Leicester, Leicester, UK
    Eur J Vasc Endovasc Surg 31:239-43. 2006
    ..We investigated the role of the novel lectin pathway of complement during IRI in patients undergoing AAA repair...
  43. doi request reprint Quality control in systematic reviews and meta-analyses
    M J Bown
    The University of Leicester, Department of Cardiovascular Sciences, Robert Kilpatrick Clinical Sciences Building, Leicester Royal Infirmary, Leicester LE2 7LX, United Kingdom
    Eur J Vasc Endovasc Surg 40:669-77. 2010
    ....
  44. ncbi request reprint Accuracy of a 12-lead electrocardiogram in screening patients with suspected heart failure for open access echocardiography: a systematic review and meta-analysis
    K Khunti
    Department of Health Sciences, Division of General Practice and Primary Health Care, University of Leicester, Leicester General Hospital, Leicester, UK
    Eur J Heart Fail 6:571-6. 2004
    ..Primary outcome measures were sensitivity and specificity, meta-analysed simultaneously to produce a Summary Receiver Operating Characteristic (SROC) curve...
  45. doi request reprint Use of implicit and explicit bayesian methods in health technology assessment
    Nicola J Cooper
    Department of Health Sciences, University of Leicester, Leicester, UK
    Int J Technol Assess Health Care 29:336-42. 2013
    ..The aim of this study was to examine the use of implicit and explicit Bayesian methods in health technology assessments and to identify whether this has changed over time...
  46. pmc Cost-effectiveness of interventions for increasing the possession of functioning smoke alarms in households with pre-school children: a modelling study
    Pedro Saramago
    Department of Health Sciences, University of Leicester, 2nd Floor Adrian Building, University Road, Leicester LE1 7RH, UK
    BMC Public Health 14:459. 2014
    ..We aimed to compare the cost effectiveness of different interventions for the uptake of 'functioning' smoke alarms and consequently for the prevention of fire-related injuries in children in the UK...
  47. pmc Finding qualitative research: an evaluation of search strategies
    Rachel L Shaw
    Department of Health Sciences, University of Leicester, 22 28 Princess Road West, Leicester, LE1 6TP, UK
    BMC Med Res Methodol 4:5. 2004
    ..However, qualitative evidence can be difficult to search for and identify, and the effectiveness of different types of search strategies is unknown...
  48. pmc Conducting a critical interpretive synthesis of the literature on access to healthcare by vulnerable groups
    Mary Dixon-Woods
    Department of Health Sciences, University of Leicester, 22 28 Princess Road West, Leicester LE1 6TP, UK
    BMC Med Res Methodol 6:35. 2006
    ..This approach is sensitised to the processes of conventional systematic review methodology and draws on recent advances in methods for interpretive synthesis...
  49. ncbi request reprint Collaborative care for depression: a cumulative meta-analysis and review of longer-term outcomes
    Simon Gilbody
    Department of Health Sciences, University of York, York, England
    Arch Intern Med 166:2314-21. 2006
    ....
  50. ncbi request reprint A systematic review of molecular and biological tumor markers in neuroblastoma
    Richard D Riley
    Departments of Health Sciences, Medical Education, University of Leicester, Leicester
    Clin Cancer Res 10:4-12. 2004
    ....
  51. doi request reprint How is evidence on test performance synthesized for economic decision models of diagnostic tests? A systematic appraisal of Health Technology Assessments in the UK since 1997
    Nicola Novielli
    Department of Health Sciences, University of Leicester, Leicester, UK
    Value Health 13:952-7. 2010
    ..The study aims to assess how evidence on diagnostic test accuracy is synthesized and used to inform economic decision modeling for HTA...
  52. ncbi request reprint Bayesian approaches to meta-analysis of ROC curves
    M Hellmich
    Department of Epidemiology and Public Health, University of Leicester, UK
    Med Decis Making 19:252-64. 1999
    ..Recommendations and suggestions for further research are made. Computer code for the more advanced methods may either be downloaded via the Internet or be found elsewhere...
  53. ncbi request reprint Searching for indirect evidence and extending the network of studies for network meta-analysis: case study in venous thromboembolic events prevention following elective total knee replacement surgery
    Pascale Dequen
    Department of Health Sciences, University of Leicester, Leicester, UK Electronic address
    Value Health 17:416-23. 2014
    ....
  54. doi request reprint How valuable are multiple treatment comparison methods in evidence-based health-care evaluation?
    Nicola J Cooper
    Department of Health Sciences, University of Leicester, University Road, Leicester, UK
    Value Health 14:371-80. 2011
    ....
  55. ncbi request reprint A systematic review and meta-analysis of endovascular repair (EVAR) for ruptured abdominal aortic aneurysm
    H S Rayt
    Department of Cardiovascular Sciences, Vascular Surgery Research Group, University of Leicester, Leicester Royal Infirmary, Leicester LE2 7LX, UK
    Eur J Vasc Endovasc Surg 36:536-44. 2008
    ..The aim of this study was to estimate the mortality rate from EVAR due to ruptured abdominal aortic aneurysm (RAAA)...
  56. ncbi request reprint An evaluation of bivariate random-effects meta-analysis for the joint synthesis of two correlated outcomes
    R D Riley
    Centre for Biostatistics and Genetic Epidemiology, Department of Health Sciences, University of Leicester, UK
    Stat Med 26:78-97. 2007
    ..Bivariate meta-regression and further research priorities are also discussed...
  57. ncbi request reprint A meta-analysis of 50 years of ruptured abdominal aortic aneurysm repair
    M J Bown
    Departments of Surgery and Epidemiology and Public Health, University of Leicester, Leicester, UK
    Br J Surg 89:714-30. 2002
    ..The aim of this study was to estimate the operative mortality of RAAA repair and determine how it has changed over time...
  58. doi request reprint Surgical versus nonsurgical treatment of acute minimally displaced and undisplaced scaphoid waist fractures: pairwise and network meta-analyses of randomized controlled trials
    Talal Ibrahim
    Division of Orthopaedic Surgery and Department of Health Sciences, University of Leicester, Leicester, United Kingdom
    J Hand Surg Am 36:1759-1768.e1. 2011
    ..To investigate the effectiveness of surgical treatment for minimally displaced and undisplaced scaphoid waist fractures compared with nonsurgical intervention through pairwise and network meta-analyses of randomized controlled trials...
  59. pmc The effectiveness of anti-TNF-alpha therapies when used sequentially in rheumatoid arthritis patients: a systematic review and meta-analysis
    Suzanne Lloyd
    Department of Health Sciences, University of Leicester, Leicester, UK
    Rheumatology (Oxford) 49:2313-21. 2010
    ..To systematically review and meta-analyse evidence on the effectiveness of the TNF-α inhibitors when used sequentially...
  60. ncbi request reprint Preventing childhood falls at home: meta-analysis and meta-regression
    Denise Kendrick
    Division of Primary Care, School of Nursing, University of Nottingham, Hucknall Primary Care Trust, Hucknall Health Centre, Nottingham, England, UK
    Am J Prev Med 35:370-379. 2008
    ..Despite social inequalities in childhood injury rates, there is a lack of evidence examining the effect of fall-prevention practices by social group...
  61. ncbi request reprint Interleukin 6 production during abdominal aortic aneurysm repair arises from the gastrointestinal tract and not the legs
    M G A Norwood
    Department of Surgery, University of Leicester, Leicester, UK
    Br J Surg 91:1153-6. 2004
    ..In this study the relative contributions of these areas to the inflammatory response were assessed during elective AAA repair...
  62. ncbi request reprint The cost-effectiveness of influenza vaccination of healthy adults 50-64 years of age
    D A Turner
    Department of Health Sciences, University of Leicester, UK
    Vaccine 24:1035-43. 2006
    ..Extension of the current immunisation policy has the potential to generate a significant health benefit at a comparatively low cost...
  63. ncbi request reprint Abdominal aortic aneurysm repair in patients with chronic renal disease
    M G A Norwood
    Department of Surgery, University of Leicester, Leicester, UK
    Eur J Vasc Endovasc Surg 27:287-91. 2004
    ..To assess the outcome of AAA repair in patients with established renal failure (RF), including patients on dialysis...
  64. ncbi request reprint Systematic review and evaluation of methods of assessing urinary incontinence
    J L Martin
    Department of Health Sciences, University of Leicester, UK
    Health Technol Assess 10:1-132, iii-iv. 2006
    ..To identify and synthesise studies of diagnostic processes of urinary incontinence and to construct an economic model to examine the cost-effectiveness of simple, commonly used primary care tests...
  65. ncbi request reprint The post-operative mortality of ruptured abdominal aortic aneurysm repair
    M J Bown
    Department of Surgery, Leicester Royal Infirmary, University of Leicester, UK
    Eur J Vasc Endovasc Surg 27:65-74. 2004
    ..Late peri-operative death after ruptured abdominal aortic aneurysm (RAAA) repair is usually due to multiple-organ failure. The aim of this study was to identify any factors that are associated with mortality in this group of patients...
  66. ncbi request reprint An illustrated guide to the methods of meta-analysis
    A J Sutton
    Department of Epidemiology and Public Health, University of Leicester, UK
    J Eval Clin Pract 7:135-48. 2001
    ..Clearly, it will be some time before they are used routinely, but significant steps have been made...
  67. ncbi request reprint A systematic review and evaluation of the use of tumour markers in paediatric oncology: Ewing's sarcoma and neuroblastoma
    R D Riley
    Department of Epidemiology and Public Health, University of Leicester, UK
    Health Technol Assess 7:1-162. 2003
  68. ncbi request reprint Systematic review and meta-analysis of 12 years of endovascular abdominal aortic aneurysm repair
    S C Franks
    Department of Cardiovascular Sciences, University of Leicester, Leicester, UK
    Eur J Vasc Endovasc Surg 33:154-71. 2007
    ..The aim of this study was to estimate these rates from the published data, and examine how this has changed as more patients have undergone ER...
  69. pmc Reporting of prognostic markers: current problems and development of guidelines for evidence-based practice in the future
    R D Riley
    Department of Epidemiology and Public Health, University of Leicester, Leicester, UK
    Br J Cancer 88:1191-8. 2003
    ..Such changes in practice would help important evidence-based reviews to be conducted in order to establish the most appropriate prognostic markers for clinical use, which should ultimately improve patient care...
  70. pmc Effectiveness of neuraminidase inhibitors in treatment and prevention of influenza A and B: systematic review and meta-analyses of randomised controlled trials
    Nicola J Cooper
    Department of Epidemiology and Public Health, University of Leicester, Leicester LE1 6TP
    BMJ 326:1235. 2003
    ..To review the clinical effectiveness of oseltamivir and zanamivir for the treatment and prevention of influenza A and B...
  71. ncbi request reprint Cost-effectiveness and value of information analyses of neuraminidase inhibitors for the treatment of influenza
    Allan J Wailoo
    Health Economics and Decision Science, ScHARR, University of Sheffield, Sheffield, UK
    Value Health 11:160-71. 2008
    ..To assess the cost-effectiveness of alternative strategies for the treatment of suspected influenza in otherwise healthy adults and to identify future research priorities using value of information analysis...
  72. ncbi request reprint Predicting costs over time using Bayesian Markov chain Monte Carlo methods: an application to early inflammatory polyarthritis
    Nicola J Cooper
    Centre for Biostatistics and Genetic Epidemiology, Department of Health Sciences, University of Leicester, UK
    Health Econ 16:37-56. 2007
    ..To obtain predicted costs on the original cost scale (rather than the log-cost scale) two different retransformation factors were applied. All analyses were carried out using Bayesian Markov chain Monte Carlo (MCMC) simulation methods...
  73. ncbi request reprint Mixed comparison of stroke prevention treatments in individuals with nonrheumatic atrial fibrillation
    Nicola J Cooper
    Centre for Biostatistics and Genetic Epidemiology, Department of Health Sciences, University of Leicester, 22 28 Princess Road West, Leicester, England
    Arch Intern Med 166:1269-75. 2006
    ..We aimed to identify different stroke prevention treatments for atrial fibrillation assessed in randomized controlled trials and to compare them within a single evidence synthesis framework...
  74. ncbi request reprint What to add to nothing? Use and avoidance of continuity corrections in meta-analysis of sparse data
    Michael J Sweeting
    MRC Biostatistics Unit, Institute of Public Health, Robinson Way, Cambridge CB2 2SR, UK
    Stat Med 23:1351-75. 2004
    ..To compare the performance of different meta-analysis methods for pooling odds ratios when applied to sparse event data with emphasis on the use of continuity corrections...
  75. pmc Role of multivitamins and mineral supplements in preventing infections in elderly people: systematic review and meta-analysis of randomised controlled trials
    Alia El-Kadiki
    Chemical Pathology Department, Royal Hallamshire Hospital, Sheffield S10 2JF
    BMJ 330:871. 2005
    ..To evaluate the effectiveness of multivitamins and mineral supplements in reducing infections in an elderly population...