V V Sumbayev

Summary

Affiliation: University of Kent
Country: UK

Publications

  1. ncbi request reprint Regulation of MAP kinase-dependent apoptotic pathway: implication of reactive oxygen and nitrogen species
    Vadim V Sumbayev
    Department of Biochemistry, Mechnikov Odessa National University, Odessa, Ukraine
    Arch Biochem Biophys 436:406-12. 2005
  2. pmc Differential role of hypoxia-inducible factor 1 alpha in toll-like receptor-mediated and allergic inflammatory reactions
    Vadim V Sumbayev
    From the University of Kent, Chatham Maritime, Kent, United Kingdom
    World Allergy Organ J 3:245-9. 2010
  3. doi request reprint Gold nanoparticles downregulate interleukin-1β-induced pro-inflammatory responses
    Vadim V Sumbayev
    Medway School of Pharmacy, University of Kent, Chatham Maritime, Kent, UK
    Small 9:472-7. 2013
  4. pmc Involvement of hypoxia-inducible factor-1 in the inflammatory responses of human LAD2 mast cells and basophils
    Vadim V Sumbayev
    Medway School of Pharmacy, University of Kent, Chatham Maritime, United Kingdom
    PLoS ONE 7:e34259. 2012
  5. doi request reprint Hypoxia-inducible factor 1 as one of the "signaling drivers" of Toll-like receptor-dependent and allergic inflammation
    Vadim V Sumbayev
    Medway School of Pharmacy, University of Kent, Anson Building, Central Avenue, Chatham Maritime, Kent ME44TB, UK
    Arch Immunol Ther Exp (Warsz) 58:287-94. 2010
  6. doi request reprint Involvement of hypoxia-inducible factor-1 HiF(1alpha) in IgE-mediated primary human basophil responses
    Vadim V Sumbayev
    Medway School of Pharmacy, University of Kent, Chatham Maritime, Kent, UK
    Eur J Immunol 39:3511-9. 2009
  7. ncbi request reprint LPS-induced Toll-like receptor 4 signalling triggers cross-talk of apoptosis signal-regulating kinase 1 (ASK1) and HIF-1alpha protein
    Vadim V Sumbayev
    Medway School of Pharmacy, University of Kent, Anson Building, Central Avenue, Chatham Maritime, Kent, United Kingdom
    FEBS Lett 582:319-26. 2008
  8. ncbi request reprint PI3 kinase and direct S-nitrosation are involved in down-regulation of apoptosis signal-regulating kinase 1 during LPS-induced Toll-like receptor 4 signalling
    Vadim V Sumbayev
    Medway School of Pharmacy, University of Kent, Anson Building, Central Avenue, Chatham Maritime, Kent ME4 4TB, United Kingdom
    Immunol Lett 115:126-30. 2008
  9. ncbi request reprint Mechanisms of hypoxic signal transduction regulated by reactive nitrogen species
    V V Sumbayev
    Medway School of Pharmacy, University of Kent and Greenwich, Kent, UK
    Scand J Immunol 65:399-406. 2007
  10. ncbi request reprint S-nitrosation of thioredoxin in the nitrogen monoxide/superoxide system activates apoptosis signal-regulating kinase 1
    Inna M Yasinska
    Department of Biochemistry, Mechnikov Odessa National University, Per Shampansky 2, Odessa 65058, Ukraine
    Arch Biochem Biophys 428:198-203. 2004

Collaborators

Detail Information

Publications18

  1. ncbi request reprint Regulation of MAP kinase-dependent apoptotic pathway: implication of reactive oxygen and nitrogen species
    Vadim V Sumbayev
    Department of Biochemistry, Mechnikov Odessa National University, Odessa, Ukraine
    Arch Biochem Biophys 436:406-12. 2005
    ..Also we have outlined other recently discovered signal transduction processes involved in the regulation of ASK1 activity and downstream pathway...
  2. pmc Differential role of hypoxia-inducible factor 1 alpha in toll-like receptor-mediated and allergic inflammatory reactions
    Vadim V Sumbayev
    From the University of Kent, Chatham Maritime, Kent, United Kingdom
    World Allergy Organ J 3:245-9. 2010
    ..Importantly, the HIF-1 transcription complex is activated in human basophils during IgE-mediated inflammatory responses. It is involved in VEGF expression and subsequent promotion of angiogenesis and in controlling energy metabolism...
  3. doi request reprint Gold nanoparticles downregulate interleukin-1β-induced pro-inflammatory responses
    Vadim V Sumbayev
    Medway School of Pharmacy, University of Kent, Chatham Maritime, Kent, UK
    Small 9:472-7. 2013
    ..Our results indicate that the anti-inflammatory activity of gold nanoparticles is associated with an extracellular interaction with IL-1β, thus opening potentially novel options for further therapeutic applications...
  4. pmc Involvement of hypoxia-inducible factor-1 in the inflammatory responses of human LAD2 mast cells and basophils
    Vadim V Sumbayev
    Medway School of Pharmacy, University of Kent, Chatham Maritime, United Kingdom
    PLoS ONE 7:e34259. 2012
    ..This transcription complex facilitates generation of both pro-angiogenic and inflammatory cytokines in mast cells but has a differential role in basophil stimulation comparing IgE-dependent triggering with innate immune stimuli...
  5. doi request reprint Hypoxia-inducible factor 1 as one of the "signaling drivers" of Toll-like receptor-dependent and allergic inflammation
    Vadim V Sumbayev
    Medway School of Pharmacy, University of Kent, Anson Building, Central Avenue, Chatham Maritime, Kent ME44TB, UK
    Arch Immunol Ther Exp (Warsz) 58:287-94. 2010
    ..Differential biochemical mechanisms employed to stabilize the protein in different cases are discussed...
  6. doi request reprint Involvement of hypoxia-inducible factor-1 HiF(1alpha) in IgE-mediated primary human basophil responses
    Vadim V Sumbayev
    Medway School of Pharmacy, University of Kent, Chatham Maritime, Kent, UK
    Eur J Immunol 39:3511-9. 2009
    ..In addition, HIF-1alpha protein alters IgE-induced ATP depletion in basophils, thus also supporting the production of the pro-allergic cytokine IL-4...
  7. ncbi request reprint LPS-induced Toll-like receptor 4 signalling triggers cross-talk of apoptosis signal-regulating kinase 1 (ASK1) and HIF-1alpha protein
    Vadim V Sumbayev
    Medway School of Pharmacy, University of Kent, Anson Building, Central Avenue, Chatham Maritime, Kent, United Kingdom
    FEBS Lett 582:319-26. 2008
    ..ASK1 contributes to the stabilisation of HIF-1alpha, most likely via activation of p38 MAP kinase...
  8. ncbi request reprint PI3 kinase and direct S-nitrosation are involved in down-regulation of apoptosis signal-regulating kinase 1 during LPS-induced Toll-like receptor 4 signalling
    Vadim V Sumbayev
    Medway School of Pharmacy, University of Kent, Anson Building, Central Avenue, Chatham Maritime, Kent ME4 4TB, United Kingdom
    Immunol Lett 115:126-30. 2008
    ..In addition, nitric oxide produced in response to exposure of THP-1 cells to LPS was found to S-nitrosate and therefore, down-regulate ASK1 activity...
  9. ncbi request reprint Mechanisms of hypoxic signal transduction regulated by reactive nitrogen species
    V V Sumbayev
    Medway School of Pharmacy, University of Kent and Greenwich, Kent, UK
    Scand J Immunol 65:399-406. 2007
    ....
  10. ncbi request reprint S-nitrosation of thioredoxin in the nitrogen monoxide/superoxide system activates apoptosis signal-regulating kinase 1
    Inna M Yasinska
    Department of Biochemistry, Mechnikov Odessa National University, Per Shampansky 2, Odessa 65058, Ukraine
    Arch Biochem Biophys 428:198-203. 2004
    ..However, approximately 4-fold of NO excess compared to a superoxide production preserved the level of dissociated ASK1 but decreased its activity due to the enzyme S-nitrosation...
  11. ncbi request reprint HIF-1 alpha protein as a target for S-nitrosation
    Vadim V Sumbayev
    University of Kaiserslautern, Faculty of Biology, Department of Cell Biology, Erwin Schrodinger Strasse, 67663 Kaiserslautern, Germany
    FEBS Lett 535:106-12. 2003
    ..In conclusion, HIF-1 alpha is a target for S-nitrosation by exogenously and endogenously produced NO...
  12. doi request reprint HIF-1alpha protein is an essential factor for protection of myeloid cells against LPS-induced depletion of ATP and apoptosis that supports Toll-like receptor 4-mediated production of IL-6
    Harjinder Lall
    Medway School of Pharmacy, University of Kent, United Kingdom
    Mol Immunol 45:3045-9. 2008
    ..On the other hand HIF-1alpha protein is selectively required for down-regulation of ASK1 activated during LPS-induced TLR4 downstream signalling...
  13. ncbi request reprint Oxidized low-density lipoprotein (oxLDL) triggers hypoxia-inducible factor-1alpha (HIF-1alpha) accumulation via redox-dependent mechanisms
    Vladimir A Shatrov
    Faculty of Biology, Department of Cell Biology, University of Kaiserslautern, Germany
    Blood 101:4847-9. 2003
    ..This finding may suggest a role of HIF-1 in atherosclerosis and oxLDL-induced pathogenesis...
  14. ncbi request reprint S-nitrosylation of thioredoxin mediates activation of apoptosis signal-regulating kinase 1
    Vadim V Sumbayev
    Department of Biochemistry, Mechnikov Odessa National University, Apt 208, Glushko Prospect 16, Odessa 65104, Ukraine
    Arch Biochem Biophys 415:133-6. 2003
    ..These results suggest that S-nitrosylation of Trx induces ASK1 activation. Treatment of cells with N-acetyl-cysteine for 2h after 8h of pretreatment with GSNO caused an increase in glutathione and nullified ASK1 activation...
  15. ncbi request reprint Nitric oxide inhibits HIF-1alpha protein accumulation under hypoxic conditions: implication of 2-oxoglutarate and iron
    Anna V Kozhukhar
    Department of Obstetrics and Gynecology, Odessa State Medical University, Marshala Govorova Street 28, Odessa 65009, Ukraine
    Biochimie 88:411-8. 2006
    ..Treatment of those cells with N-acetyl cysteine (NAC) increased the amount of intracellular GSH and attenuated the NO effect and abolished the damage of mitochondria as well as 2-OG/iron release...
  16. ncbi request reprint S-nitrosation of Cys-800 of HIF-1alpha protein activates its interaction with p300 and stimulates its transcriptional activity
    Inna M Yasinska
    Department of Biochemistry, Mechnikov Odessa National University, Apt 208, Glushko Prospect 16, Odessa 65104, Ukraine
    FEBS Lett 549:105-9. 2003
    ..Experiments with GST pull-down assay suggest that S-nitrosation of Cys-800 stimulates the recruitment of p300 co-activator protein to the HIF-1alpha C-terminal domain...
  17. doi request reprint Protein S-nitrosation in signal transduction: assays for specific qualitative and quantitative analysis
    Vadim V Sumbayev
    Medway School of Pharmacy, University of Kent, United Kingdom
    Methods Enzymol 440:209-19. 2008
    ..This chapter describes and discusses recently developed methods that allow both qualitative and quantitative analyses of S-nitrosation of intracellular proteins based on Western blot and enzyme-linked immunosorbent assay...
  18. ncbi request reprint Mesangial cells but not hepatocytes are protected against NO/O(2)(-) cogeneration: mechanistic considerations
    Vadim V Sumbayev
    Department of Cell Biology, Faculty of Biology, University of Kaiserslautern, Erwin Schrodinger Strasse, 67663, Kaiserslautern, Germany
    Eur J Pharmacol 444:1-11. 2002
    ..In conclusion, NO/O(2)(-) sensitivity is cell type specific and is determined by the glutathione redox system...