John Suckling

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. pmc Aberrant NF-kappaB expression in autism spectrum condition: a mechanism for neuroinflammation
    Adam M H Young
    Bute Medical School, University of St Andrews Fife, Scotland, UK
    Front Psychiatry 2:27. 2011
  2. pmc Regional susceptibility to TNF-α induction of murine brain inflammation via classical IKK/NF-κB signalling
    Adam M H Young
    School of Medicine, University of St Andrews, Fife, Scotland, United Kingdom
    PLoS ONE 7:e39049. 2012
  3. pmc Assessment of the impact of the scanner-related factors on brain morphometry analysis with Brainvisa
    Mahsa Shokouhi
    Department of Clinical Physics and Psychological Medicine, College of Medicine, Veterinary and Life Sciences, University of Glasgow, UK
    BMC Med Imaging 11:23. 2011
  4. ncbi request reprint Permutation tests for factorially designed neuroimaging experiments
    John Suckling
    Brain Mapping Unit and Wolfson Brain Imaging Centre, University of Cambridge, Cambridge, United Kingdom
    Hum Brain Mapp 22:193-205. 2004
  5. pmc Endogenous multifractal brain dynamics are modulated by age, cholinergic blockade and cognitive performance
    John Suckling
    Brain Mapping Unit, University of Cambridge, Department of Psychiatry, Addenbrooke s Hospital, Cambridge CB2 0QQ, UK
    J Neurosci Methods 174:292-300. 2008
  6. doi request reprint Power calculations for multicenter imaging studies controlled by the false discovery rate
    John Suckling
    Department of Psychiatry and Behavioural and Clinical Neurosciences Institute, University of Cambridge, United Kingdom
    Hum Brain Mapp 31:1183-95. 2010
  7. doi request reprint The Neuro/PsyGRID calibration experiment: identifying sources of variance and bias in multicenter MRI studies
    John Suckling
    Department of Psychiatry and Behavioural and Clinical Neurosciences Institute, Brain Mapping Unit, University of Cambridge, Cambridge, UK
    Hum Brain Mapp 33:373-86. 2012
  8. ncbi request reprint Permutation testing of orthogonal factorial effects in a language-processing experiment using fMRI
    John Suckling
    Brain Mapping Unit, Department of Psychiatry, University of Cambridge, UK
    Hum Brain Mapp 27:425-33. 2006
  9. ncbi request reprint Components of variance in a multicentre functional MRI study and implications for calculation of statistical power
    John Suckling
    Brain Mapping Unit, Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom
    Hum Brain Mapp 29:1111-22. 2008
  10. doi request reprint Response perseveration in stimulant dependence is associated with striatal dysfunction and can be ameliorated by a D(2/3) receptor agonist
    Karen D Ersche
    Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom
    Biol Psychiatry 70:754-62. 2011

Detail Information

Publications82

  1. pmc Aberrant NF-kappaB expression in autism spectrum condition: a mechanism for neuroinflammation
    Adam M H Young
    Bute Medical School, University of St Andrews Fife, Scotland, UK
    Front Psychiatry 2:27. 2011
    ....
  2. pmc Regional susceptibility to TNF-α induction of murine brain inflammation via classical IKK/NF-κB signalling
    Adam M H Young
    School of Medicine, University of St Andrews, Fife, Scotland, United Kingdom
    PLoS ONE 7:e39049. 2012
    ....
  3. pmc Assessment of the impact of the scanner-related factors on brain morphometry analysis with Brainvisa
    Mahsa Shokouhi
    Department of Clinical Physics and Psychological Medicine, College of Medicine, Veterinary and Life Sciences, University of Glasgow, UK
    BMC Med Imaging 11:23. 2011
    ..It is important therefore to investigate the variability and reliability of morphometric measurements between different scanners and different sessions of the same scanner...
  4. ncbi request reprint Permutation tests for factorially designed neuroimaging experiments
    John Suckling
    Brain Mapping Unit and Wolfson Brain Imaging Centre, University of Cambridge, Cambridge, United Kingdom
    Hum Brain Mapp 22:193-205. 2004
    ..Antidepressant drug effects in left amygdala and ventral striatum were detected by this software for an interaction between time (within-subject factor) and group (between-subject factor) in a representative two-way factorial design...
  5. pmc Endogenous multifractal brain dynamics are modulated by age, cholinergic blockade and cognitive performance
    John Suckling
    Brain Mapping Unit, University of Cambridge, Department of Psychiatry, Addenbrooke s Hospital, Cambridge CB2 0QQ, UK
    J Neurosci Methods 174:292-300. 2008
    ....
  6. doi request reprint Power calculations for multicenter imaging studies controlled by the false discovery rate
    John Suckling
    Department of Psychiatry and Behavioural and Clinical Neurosciences Institute, University of Cambridge, United Kingdom
    Hum Brain Mapp 31:1183-95. 2010
    ..At 80% power 80 participants per group are required to observe differences in gray matter in high variance regions...
  7. doi request reprint The Neuro/PsyGRID calibration experiment: identifying sources of variance and bias in multicenter MRI studies
    John Suckling
    Department of Psychiatry and Behavioural and Clinical Neurosciences Institute, Brain Mapping Unit, University of Cambridge, Cambridge, UK
    Hum Brain Mapp 33:373-86. 2012
    ..Rank tests were highly significant indicating the order of measures across centers was preserved. In summary, center effects should be modeled at the voxel-level using existing and long-standing statistical recommendations...
  8. ncbi request reprint Permutation testing of orthogonal factorial effects in a language-processing experiment using fMRI
    John Suckling
    Brain Mapping Unit, Department of Psychiatry, University of Cambridge, UK
    Hum Brain Mapp 27:425-33. 2006
    ..The small size of the BOLD effect necessitates sensitive methods of detection of brain activation. Permutation methods permit the necessary flexibility to develop novel test statistics to meet this challenge...
  9. ncbi request reprint Components of variance in a multicentre functional MRI study and implications for calculation of statistical power
    John Suckling
    Brain Mapping Unit, Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom
    Hum Brain Mapp 29:1111-22. 2008
    ..Thus, theoretical models of power and empirical data indicate that between-centre variability can be small enough to encourage multicentre designs without major compensatory increases in sample size...
  10. doi request reprint Response perseveration in stimulant dependence is associated with striatal dysfunction and can be ameliorated by a D(2/3) receptor agonist
    Karen D Ersche
    Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom
    Biol Psychiatry 70:754-62. 2011
    ..The aim of this study was to measure behavioral and neural markers of compulsivity in stimulant-dependent individuals and to test whether these markers could be modulated by treatment with drugs targeting the dopamine system...
  11. doi request reprint Neuregulin-1 genotype is associated with structural differences in the normal human brain
    Anna Barnes
    Department of Psychiatry, University of Cambridge, Box 189 Addenbrooke s Hospital, Cambridge CB2 2QQ, UK
    Neuroimage 59:2057-61. 2012
    ..These results suggest that this genetic variant may mediate risk for schizophrenia, in part, through its effect on brain structure in these regions...
  12. pmc Psychological correlates of handedness and corpus callosum asymmetry in autism: the left hemisphere dysfunction theory revisited
    Dorothea L Floris
    Department of Psychiatry, Autism Research Centre, University of Cambridge, Cambridge, UK
    J Autism Dev Disord 43:1758-72. 2013
    ..We found the opposite pattern for the isthmus and rostrum with better cognitive and less severe clinical scores associated with rightward lateralization. ..
  13. pmc Biological sex affects the neurobiology of autism
    Meng Chuan Lai
    Autism Research Centre, Department of Psychiatry, University of Cambridge, Douglas House, 18B, Trumpington Road, Cambridge CB2 8AH, UK
    Brain 136:2799-815. 2013
    ..Future research should stratify by biological sex to reduce heterogeneity and to provide greater insight into the neurobiology of autism. ..
  14. pmc No association of COMT (Val158Met) genotype with brain structure differences between men and women
    Anna Barnes
    Department of Psychiatry, University of Cambridge, Addenbrooke s Hospital, Cambridge, United Kingdom
    PLoS ONE 7:e33964. 2012
    ....
  15. pmc Grey matter abnormalities in trichotillomania: morphometric magnetic resonance imaging study
    Samuel R Chamberlain
    Department of Psychiatry, University of Cambridge, Cambridge CB2 2QQ, UK
    Br J Psychiatry 193:216-21. 2008
    ..Trichotillomania (repetitive hair-pulling) is an Axis I psychiatric disorder whose neurobiological basis is incompletely understood. Whole-brain trichotillomania neuroimaging studies are lacking...
  16. ncbi request reprint Effects of gamma-aminobutyric acid-modulating drugs on working memory and brain function in patients with schizophrenia
    Lara Menzies
    Brain Mapping Unit, Department of Psychiatry, University of Cambridge, Addenbrooke s Hospital, Cambridge, England
    Arch Gen Psychiatry 64:156-67. 2007
    ..Cognitive impairment causes morbidity in schizophrenia and could be due to abnormalities of cortical interneurons using the inhibitory neurotransmitter gamma-aminobutyric acid (GABA)...
  17. ncbi request reprint Functional coupling of the amygdala in depressed patients treated with antidepressant medication
    Chi Hua Chen
    Department of Psychiatry, Brain Mapping Unit, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Neuropsychopharmacology 33:1909-18. 2008
    ....
  18. pmc Individual differences in brain structure underpin empathizing-systemizing cognitive styles in male adults
    Meng Chuan Lai
    Autism Research Centre, Department of Psychiatry, University of Cambridge Douglas House, 18B, Trumpington Road, Cambridge CB2 8AH, UK
    Neuroimage 61:1347-54. 2012
    ..These results suggest an underlying neuroanatomical basis linked to the discrepancy between these two important dimensions of individual differences in cognitive style...
  19. doi request reprint Shared neural circuits for mentalizing about the self and others
    Michael V Lombardo
    University of Cambridge, United Kingdom
    J Cogn Neurosci 22:1623-35. 2010
    ....
  20. pmc Influence of compulsivity of drug abuse on dopaminergic modulation of attentional bias in stimulant dependence
    Karen D Ersche
    University of Cambridge, Behavioural and Clinical Neuroscience Institute, Department of Psychiatry, Cambridge, England
    Arch Gen Psychiatry 67:632-44. 2010
    ..We hypothesized that dopamine-related targets are relevant for treatment of stimulant dependence, and there will likely be individual differences in response to dopaminergic challenges...
  21. ncbi request reprint Brain imaging correlates of depressive symptom severity and predictors of symptom improvement after antidepressant treatment
    Chi Hua Chen
    Brain Mapping Unit, University of Cambridge, Department of Psychiatry, Addenbrooke s Hospital, Cambridge, UK
    Biol Psychiatry 62:407-14. 2007
    ..It would be therapeutically useful to predict clinical response to antidepressant drugs. We evaluated structural magnetic resonance imaging (MRI) and functional MRI (fMRI) data as predictors of symptom change in people with depression...
  22. pmc Atypical activation during the Embedded Figures Task as a functional magnetic resonance imaging endophenotype of autism
    Michael D Spencer
    Department of Psychiatry, University of Cambridge, Autism Research Centre, Douglas House, 18 b Trumpington Road, Cambridge CB2 8AH, UK
    Brain 135:3469-80. 2012
    ....
  23. pmc Consistency and interpretation of changes in millimeter-scale cortical intrinsic curvature across three independent datasets in schizophrenia
    Lisa Ronan
    Brain Mapping Unit, Department of Psychiatry, University of Cambridge, Cambridge, UK
    Neuroimage 63:611-21. 2012
    ..The results suggest that reduced gyrification in schizophrenia is driven by a reduction in the expansion of upper cortical layers. This may plausibly be related to a reduction in short-range connectivity...
  24. pmc Resampling methods for improved wavelet-based multiple hypothesis testing of parametric maps in functional MRI
    Levent Sendur
    Brain Mapping Unit, University of Cambridge, Addenbrooke s Hospital, Cambridge CB2 0QQ, UK
    Neuroimage 37:1186-94. 2007
    ....
  25. doi request reprint A shift to randomness of brain oscillations in people with autism
    Meng Chuan Lai
    Autism Research Centre, Department of Psychiatry, University of Cambridge, United Kingdom
    Biol Psychiatry 68:1092-9. 2010
    ..5) to ordered (H = 1). Shifts in fractal scaling of physiological time series have been associated with neurological and cardiac conditions...
  26. ncbi request reprint Wavelets and functional magnetic resonance imaging of the human brain
    Ed Bullmore
    Brain Mapping Unit and Wolfson Brain Imaging Centre, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Neuroimage 23:S234-49. 2004
    ..We conclude that the wavelet domain is a rich source of new concepts and techniques to enhance the power of statistical analysis of human fMRI data...
  27. doi request reprint Atomoxetine modulates right inferior frontal activation during inhibitory control: a pharmacological functional magnetic resonance imaging study
    Samuel R Chamberlain
    Department of Psychiatry, University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, University of Cambridge, Cambridge, UK
    Biol Psychiatry 65:550-5. 2009
    ..However, the mechanisms by which atomoxetine improves inhibitory control have yet to be determined...
  28. ncbi request reprint Explicit and implicit facial affect recognition in manic and depressed States of bipolar disorder: a functional magnetic resonance imaging study
    Chi Hua Chen
    Brain Mapping Unit and Wolfson Brain Imaging Centre, Department of Psychiatry, University of Cambridge, UK
    Biol Psychiatry 59:31-9. 2006
    ..Facial affect processing paradigms are an effective way of studying behavioral and functional magnetic resonance imaging (fMRI) correlates of affective disorders...
  29. doi request reprint Monofractal and multifractal dynamics of low frequency endogenous brain oscillations in functional MRI
    Alle Meije Wink
    Brain Mapping Unit, Department of Psychiatry, Addenbrooke s Hospital, University of Cambridge, Cambridge, United Kingdom
    Hum Brain Mapp 29:791-801. 2008
    ....
  30. doi request reprint The brain structural disposition to social interaction
    Maël Lebreton
    Brain Mapping Unit, University of Cambridge, Cambridge, UK
    Eur J Neurosci 29:2247-52. 2009
    ..These findings provide evidence for a brain structural disposition to social interaction, and that sensitivity to social reward shares a common neural basis with systems for processing primary reward information...
  31. doi request reprint Detection of physiological noise in resting state fMRI using machine learning
    Tom Ash
    Wolfson Brain Imaging Centre, University of Cambridge, Cambridge, United Kingdom
    Hum Brain Mapp 34:985-98. 2013
    ..This technique has a use in situations where data from direct monitoring of the cardiac and respiratory cycles are incomplete or absent, but researchers still wish to reduce this source of noise in the image data...
  32. ncbi request reprint Fractional Gaussian noise, functional MRI and Alzheimer's disease
    Voichita Maxim
    Department of Psychiatry, Brain Mapping Unit, University of Cambridge, Addenbrooke s Hospital, Cambridge CB2 2QQ, UK
    Neuroimage 25:141-58. 2005
    ..We conclude that parsimonious mapping of fMRI noise properties in terms of fGn parameters efficiently estimated in the wavelet domain is feasible and can enhance insight into the pathophysiology of Alzheimer's disease...
  33. ncbi request reprint A resilient, low-frequency, small-world human brain functional network with highly connected association cortical hubs
    Sophie Achard
    Wolfson Brain Imaging Centre, University of Cambridge, Department of Psychiatry, Addenbrooke s Hospital, Cambridge CB2 2QQ, United Kingdom
    J Neurosci 26:63-72. 2006
    ..Because the major hubs of this network are critical for cognition, its slow dynamics could provide a physiological substrate for segregated and distributed information processing...
  34. ncbi request reprint Age and cholinergic effects on hemodynamics and functional coherence of human hippocampus
    Alle Meije Wink
    Brain Mapping Unit and Wolfson Brain Imaging Centre, University of Cambridge, Department of Psychiatry, Addenbrooke s Hospital, Cambridge CB2 2QQ, UK
    Neurobiol Aging 27:1395-404. 2006
    ....
  35. ncbi request reprint Neurophysiological architecture of functional magnetic resonance images of human brain
    Raymond Salvador
    Brain Mapping Unit and Wolfson Brain Imaging Centre, University of Cambridge, Addenbrooke s Hospital, Cambridge CB2 2QQ, UK
    Cereb Cortex 15:1332-42. 2005
    ....
  36. doi request reprint White matter abnormalities in patients with obsessive-compulsive disorder and their first-degree relatives
    Lara Menzies
    Brain Mapping Unit, Department of Psychiatry, University of Cambridge, Addenbrooke s Hospital, Cambridge CB22QQ, UK
    Am J Psychiatry 165:1308-15. 2008
    ..They also explored whether such abnormalities occur in healthy first-degree relatives of patients, indicating they may be endophenotypes representing increased genetic risk for OCD...
  37. doi request reprint A quantitative meta-analysis of fMRI studies in bipolar disorder
    Chi Hua Chen
    Brain Mapping Unit, Department of Psychiatry, University of Cambridge GlaxoSmithKline Clinical Unit Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Bipolar Disord 13:1-15. 2011
    ..This review aimed to synthesize current evidence from fMRI studies in midlife adults with BD and to investigate whether there is support for the theoretical models of the disorder...
  38. pmc Failure to deactivate the default mode network indicates a possible endophenotype of autism
    Michael D Spencer
    Department of Psychiatry, Autism Research Centre, University of Cambridge, Douglas House, 18b Trumpington Road, Cambridge, CB2 8AH, UK
    Mol Autism 3:15. 2012
    ..abstract:..
  39. ncbi request reprint Functional disconnectivity of the medial temporal lobe in Asperger's syndrome
    David E Welchew
    Brain Mapping Unit, University of Cambridge, Cambridge, United Kingdom
    Biol Psychiatry 57:991-8. 2005
    ..Autistic spectrum disorders (ASD) are neurodevelopmental conditions that may be caused by abnormal connectivity between brain regions constituting neurocognitive networks for specific aspects of social cognition...
  40. doi request reprint Orbitofrontal dysfunction in patients with obsessive-compulsive disorder and their unaffected relatives
    Samuel R Chamberlain
    Department of Psychiatry, University of Cambridge, Addenbrooke s Hospital, Box 189, Cambridge CB2 0QQ, UK
    Science 321:421-2. 2008
    ....
  41. pmc CamBAfx: Workflow Design, Implementation and Application for Neuroimaging
    Cinly Ooi
    Brain Mapping Unit, Department of Psychiatry, University of Cambridge Cambridge, UK
    Front Neuroinform 3:27. 2009
    ..CamBAfx's design, licensing and Eclipse Branding Mechanism allow it to be used as the user interface for other software, facilitating exchange of innovative computational tools between originating labs...
  42. pmc Undirected graphs of frequency-dependent functional connectivity in whole brain networks
    Raymond Salvador
    Brain Mapping Unit and Wolfson Brain Imaging Centre, Department of Psychiatry, Addenbrooke s Hospital, University of Cambridge, Cambridge CB2 2QQ, UK
    Philos Trans R Soc Lond B Biol Sci 360:937-46. 2005
    ....
  43. doi request reprint A positron emission tomography study of nigro-striatal dopaminergic mechanisms underlying attention: implications for ADHD and its treatment
    Natalia Del Campo
    1 Department of Psychiatry, University of Cambridge, Addenbrooke s Hospital, Cambridge CB2 0QQ, UK
    Brain 136:3252-70. 2013
    ..This conclusion is reinforced by evidence of neuroanatomical changes in the same set of patients with attention deficit/hyperactivity disorder. ..
  44. pmc Improving mood with psychoanalytic and cognitive therapies (IMPACT): a pragmatic effectiveness superiority trial to investigate whether specialised psychological treatment reduces the risk for relapse in adolescents with moderate to severe unipolar depres
    Ian M Goodyer
    Department of Psychiatry, University of Cambridge and the Cambridge and Peterborough Foundation Trust, Douglas House, 18b Trumpington Road Cambridge, UK
    Trials 12:175. 2011
    ..The specific efficacy of different psychological therapies and the moderators and mediators that influence risk for relapse are unclear. The cost-effectiveness and safety of psychological treatments remain poorly evaluated...
  45. doi request reprint Generic aspects of complexity in brain imaging data and other biological systems
    Ed Bullmore
    Behavioural and Clinical Neurosciences Institute, University of Cambridge, Department of Psychiatry, Addenbrooke s, Hospital, Cambridge, UK
    Neuroimage 47:1125-34. 2009
    ..The aim is to provide a didactic, focussed and user-friendly introduction to the concepts of complexity science for neuroscientists and neuroimagers...
  46. pmc Endogenous human brain dynamics recover slowly following cognitive effort
    Anna Barnes
    Brain Mapping Unit, Behavioural and Clinical Neurosciences Institute, Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom
    PLoS ONE 4:e6626. 2009
    ..effortful task significantly change fractal scaling properties of fMRI time series compared to their values before task performance? 2) If so, can we relate the extent of task-related perturbation to the difficulty of the task?..
  47. pmc Fronto-cerebellar systems are associated with infant motor and adult executive functions in healthy adults but not in schizophrenia
    Khanum Ridler
    Brain Mapping Unit, Department of Psychiatry, Addenbrooke s Hospital, University of Cambridge, Cambridge CB2 2QQ, United Kingdom
    Proc Natl Acad Sci U S A 103:15651-6. 2006
    ..Disruption of this anatomical system may underlie both the early developmental and adult cognitive abnormalities in schizophrenia...
  48. pmc Intrinsic curvature: a marker of millimeter-scale tangential cortico-cortical connectivity?
    Lisa Ronan
    Brain Mapping Unit, Department of Psychiatry, University of Cambridge, Cambridge, UK
    Int J Neural Syst 21:351-66. 2011
    ..Thus, the degree of cortical intrinsic curvature may have implications for short-range connectivity...
  49. ncbi request reprint Wavelets and statistical analysis of functional magnetic resonance images of the human brain
    Ed Bullmore
    Brain Mapping Unit and Wolfson Brain Imaging Centre, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Stat Methods Med Res 12:375-99. 2003
    ....
  50. pmc Practice and difficulty evoke anatomically and pharmacologically dissociable brain activation dynamics
    Ed Bullmore
    University of Cambridge, Department of Psychiatry, Addenbrooke s Hospital, Cambridge CB2 2QQ
    Cereb Cortex 13:144-54. 2003
    ..Difficulty and practice evoke anatomically and pharmacologically dissociable brain activation dynamics, which are probably mediated by different neurotransmitter systems in humans...
  51. ncbi request reprint Variations in the human cannabinoid receptor (CNR1) gene modulate striatal responses to happy faces
    Bhismadev Chakrabarti
    Autism Research Centre, Douglas House, 18 B, Trumpington Road, Cambridge CB2 2AH, UK
    Eur J Neurosci 23:1944-8. 2006
    ..This has implications for medical conditions involving hypo-responsivity to emotional and social stimuli, such as autism...
  52. doi request reprint Atypical neural self-representation in autism
    Michael V Lombardo
    Autism Research Centre, Douglas House, Cambridge CB2 8AH, UK
    Brain 133:611-24. 2010
    ..These observations reveal that the atypical organization of neural circuitry preferentially coding for self-information is a key mechanism at the heart of both self-referential and social impairments in autism...
  53. pmc Magnetic resonance imaging of a randomized controlled trial investigating predictors of recovery following psychological treatment in adolescents with moderate to severe unipolar depression: study protocol for Magnetic Resonance-Improving Mood with Psycho
    Cindy C Hagan
    Department of Psychiatry, University of Cambridge, Herchel Smith Building for Brain and Mind Sciences, Robinson Way, Cambridge CB2 0SZ, UK
    BMC Psychiatry 13:247. 2013
    ..Information with respect to optimal treatment choice for individuals is lacking, with no validated biomarkers to aid therapeutic decision-making...
  54. doi request reprint Meta-analytic evidence for neuroimaging models of depression: state or trait?
    Julia Graham
    Department of Psychiatry, University of Cambridge, UK Electronic address
    J Affect Disord 151:423-31. 2013
    ..Here, we aim to clarify the support in fMRI literature for three leading neurobiological models of MDD: limbic-cortical, cortico-striatal and the default mode network...
  55. ncbi request reprint Standardized whole brain mapping of tubers and subependymal nodules in tuberous sclerosis complex
    Khanum Ridler
    University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    J Child Neurol 19:658-65. 2004
    ..Contemporary image processing tools can be used to enhance quantitative, whole brain analysis of lesion load in patients with tuberous sclerosis complex...
  56. ncbi request reprint Neural systems underlying British Sign Language and audio-visual English processing in native users
    Mairead MacSweeney
    BBSU, Institute of Child Health, University College London, UK
    Brain 125:1583-93. 2002
    ..However, in the absence of auditory input this region can be recruited for visual processing...
  57. ncbi request reprint Brain anatomy and sensorimotor gating in Asperger's syndrome
    Grainne M McAlonan
    Department of Psychological Medicine, Institute of Psychiatry, London, UK
    Brain 125:1594-606. 2002
    ....
  58. ncbi request reprint A computational morphometric MRI study of schizophrenia: effects of hallucinations
    Jane Shapleske
    Department of Psychological Medicine, Institute of Psychiatry, London SE5 8AF, UK
    Cereb Cortex 12:1331-41. 2002
    ....
  59. ncbi request reprint Mapping the brain in autism. A voxel-based MRI study of volumetric differences and intercorrelations in autism
    Grainne M McAlonan
    Department of Psychiatry, University of Hong Kong, Pokfulam, Hong Kong, SAR China
    Brain 128:268-76. 2005
    ..Taken together, our data suggest abnormalities in the anatomy and connectivity of limbic-striatal 'social' brain systems which may contribute to the brain metabolic differences and behavioural phenotype in autism...
  60. ncbi request reprint Different effects of typical and atypical antipsychotics on grey matter in first episode psychosis: the AESOP study
    Paola Dazzan
    Division of Psychological Medicine, Institute of Psychiatry, King s College, London, UK
    Neuropsychopharmacology 30:765-74. 2005
    ..In conclusion, we would like to suggest that even after short-term treatment, typical and atypical antipsychotics may affect brain structure differently...
  61. ncbi request reprint Frontotemporal white matter changes in amyotrophic lateral sclerosis
    Sharon Abrahams
    Dept of Psychology, University of Edinburgh, 7 George Square, Edinburgh EH8 9JZ, Scotland
    J Neurol 252:321-31. 2005
    ..The findings support the hypothesis of a continuum of extra-motor cerebral and cognitive change in this disorder...
  62. ncbi request reprint Cerebral grey, white matter and csf in never-medicated, first-episode schizophrenia
    Siew E Chua
    Department of Psychiatry, Queen Mary Hospital, The University of Hong Kong, 102 Pokfulam Road, Hong Kong, S A R China
    Schizophr Res 89:12-21. 2007
    ..Ratio of lateral ventricle to caudate volume was bilaterally significantly increased (p<0.005, 2-tailed), which could represent an early biomarker in first-episode, never-medicated schizophrenia...
  63. ncbi request reprint Neural responses to happy facial expressions in major depression following antidepressant treatment
    Cynthia H Y Fu
    Institute of Psychiatry, King s College London, 103 Denmark Hill, London SE5 8AF, UK
    Am J Psychiatry 164:599-607. 2007
    ..However, depressed patients show impairments in this system. The present study investigated the neural correlates of implicit processing of happy facial expressions in depression and identified regions affected by antidepressant therapy...
  64. doi request reprint Grey matter abnormalities in first-episode schizophrenia and affective psychosis
    Kevin D Morgan
    Department of Psychology, University of Westminster, 309 Regent Street, London W1B 2UW, UK
    Br J Psychiatry Suppl 51:s111-6. 2007
    ..Grey matter and other structural brain abnormalities are consistently reported in first-onset schizophrenia, but less is known about the extent of neuroanatomical changes in first-onset affective psychosis...
  65. ncbi request reprint A longitudinal functional magnetic resonance imaging study of verbal working memory in depression after antidepressant therapy
    Nicholas D Walsh
    Institute of Psychiatry, King s College London, De Crespigny Park, 103 Denmark Hill, London, UK
    Biol Psychiatry 62:1236-43. 2007
    ..Impairments in the neural circuitry of verbal working memory are evident in depression. Factors of task demand and depressive state might have significant effects on its functional neuroanatomy...
  66. ncbi request reprint Searching for a structural endophenotype in psychosis using computational morphometry
    Machteld Marcelis
    Department of Psychiatry and Neuropsychology, European Graduate School of Neuroscience, Maastricht University, P O Box 616, 6200 MD Maastricht, The Netherlands
    Psychiatry Res 122:153-67. 2003
    ..Patients with psychosis and first-degree healthy relatives of patients with psychosis show cerebellar abnormalities, which may constitute a marker of genetic transmission...
  67. ncbi request reprint fMRI study of recognition of facial expressions in high-functioning autistic patients
    Masahiro Ogai
    Department of Psychiatry and Neurology, University School of Medicine, 20 I, Handayama I chome, Hamamatsu 431 3192, Japan
    Neuroreport 14:559-63. 2003
    ..Patients with autistic disorder may have difficulty in grasping facially expressed qemotions in others, and thereby cannot manipulate the interpersonally derived information...
  68. ncbi request reprint Mapping brain structure in attention deficit-hyperactivity disorder: a voxel-based MRI study of regional grey and white matter volume
    Grainne M McAlonan
    Department of Psychiatry, University of Hong Kong
    Psychiatry Res 154:171-80. 2007
    ..Overall, restricted structural brain abnormalities caused by ADHD were localized to brain systems known to be necessary for attention and executive function...
  69. ncbi request reprint Duration of prodromal phase and severity of volumetric abnormalities in first-episode psychosis
    Julia M Lappin
    King s College London, Institute of Psychiatry, London, UK
    Br J Psychiatry Suppl 51:s123-7. 2007
    ..First-episode psychosis is typically preceded by a prodrome in which there is deterioration in global and social functioning...
  70. ncbi request reprint A functional magnetic resonance imaging study of overt letter verbal fluency using a clustered acquisition sequence: greater anterior cingulate activation with increased task demand
    Cynthia H Y Fu
    Institute of Psychiatry, King s College London, London SE5 8AF, United Kingdom
    Neuroimage 17:871-9. 2002
    ..This may reflect the greater demands of the former, particularly in terms of arousal responses with increased task difficulty and the monitoring of potential response errors...
  71. ncbi request reprint Procedural learning in schizophrenia: a functional magnetic resonance imaging investigation
    Veena Kumari
    Section of Cognitive Psychopharmacology, Division of Psychological Medicine, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London, UK
    Schizophr Res 57:97-107. 2002
    ....
  72. ncbi request reprint Increased duration of illness is associated with reduced volume in right medial temporal/anterior cingulate grey matter in patients with chronic schizophrenia
    Dennis Velakoulis
    Cognitive Neuropsychiatry Research and Academic Unit, Department of Psychiatry, University of Melbourne and Sunshine Hospital, St Albans, Australia
    Schizophr Res 57:43-9. 2002
    ..The inverse correlation between right frontal, temporal and cerebellar volumes and the time since the onset of schizophrenia could reflect progressive tissue loss following the first episode of the disorder...
  73. ncbi request reprint The structural brain correlates of neurological soft signs in AESOP first-episode psychoses study
    Paola Dazzan
    Division of Psychological Medicine, Box 63, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
    Brain 127:143-53. 2004
    ....
  74. ncbi request reprint Detection of structural differences between the brains of schizophrenic patients and controls
    Vassili A Kovalev
    School of Electronics and Physical Sciences, University of Surrey, GU2 7XH, Guildford, UK
    Psychiatry Res 124:177-89. 2003
    ....
  75. ncbi request reprint Heterozygous PAX6 mutation, adult brain structure and fronto-striato-thalamic function in a human family
    Zoë Ellison-Wright
    Institute of Psychiatry, King s College London, De Crespigny Park, London SE5 8AF, UK
    Eur J Neurosci 19:1505-12. 2004
    ..Highly conserved homeobox genes may be critical for normal ontogenesis of large-scale neurocognitive networks supporting phylogenetically advanced mental functions...
  76. ncbi request reprint Attenuation of the neural response to sad faces in major depression by antidepressant treatment: a prospective, event-related functional magnetic resonance imaging study
    Cynthia H Y Fu
    Institute of Psychiatry, King s College London, London, England
    Arch Gen Psychiatry 61:877-89. 2004
    ..Depression is associated with interpersonal difficulties related to abnormalities in affective facial processing...
  77. ncbi request reprint The effect of pre-mutation of X chromosome CGG trinucleotide repeats on brain anatomy
    Caroline J Moore
    Division of Psychological Medicine, Department of Neurology, Institute of Psychiatry, King s College London, DeCrespigny Park, UK
    Brain 127:2672-81. 2004
    ..Moreover, our findings suggest, for the first time, an association between voxel density reduction and genetic variation in FraX...
  78. ncbi request reprint Effects of psychotic state and task demand on prefrontal function in schizophrenia: an fMRI study of overt verbal fluency
    Cynthia H Y Fu
    Division of Psychological Medicine, Institute of Psychiatry, 103 Denmark Hill, London SE5 8AF UK
    Am J Psychiatry 162:485-94. 2005
    ....
  79. ncbi request reprint Effects of ketamine on prefrontal and striatal regions in an overt verbal fluency task: a functional magnetic resonance imaging study
    Cynthia H Y Fu
    Institute of Psychiatry, King s College London, De Crespigny Park, London SE5 8AF, UK
    Psychopharmacology (Berl) 183:92-102. 2005
    ..Glutamatergic dysfunction at N-methyl-D: -aspartate (NMDA) receptors has been proposed as a neurochemical model for schizophrenia. A key feature of this disorder is impairments in cognitive function...
  80. ncbi request reprint Gray matter abnormalities associated with duration of untreated psychosis
    Julia M Lappin
    Kings College London Institute of Psychiatry, PO63, Division of Psychological Medicine, King s College London, London SE5 8AF, United Kingdom
    Schizophr Res 83:145-53. 2006
    ..In order to identify whether an anatomically mediated mechanism may give rise to poorer outcomes, it is important to identify whether a long DUP is associated with greater brain structural abnormalities...
  81. ncbi request reprint Evidence that brain tissue volumes are associated with HVA reactivity to metabolic stress in schizophrenia
    Machteld Marcelis
    Department of Psychiatry and Neuropsychology, South Limburg Mental Health Research and Teaching Network, EURON, Maastricht University, Maastricht, The Netherlands
    Schizophr Res 86:45-53. 2006
    ..Relationship to prefrontal cortex volume. Arch. Gen. Psychiatry 50(7), 541-550] reported that lower prefrontal cortex volume was associated with altered metabolic stress response, but this finding has never been replicated...
  82. ncbi request reprint Informatics in Radiology (infoRAD): Magnetic Resonance Imaging Workbench: analysis and visualization of dynamic contrast-enhanced MR imaging data
    James A d'Arcy
    Cancer Research UK Clinical MR Research Group, Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Downs Road, Sutton, Surrey, United Kingdom SM2 5PT
    Radiographics 26:621-32. 2006
    ..MRIW is written in IDL, enabling it to be used on a variety of computer systems...