Vasanta Subramanian

Summary

Affiliation: University of Bath
Country: UK

Publications

  1. ncbi request reprint A new role for angiogenin in neurite growth and pathfinding: implications for amyotrophic lateral sclerosis
    Vasanta Subramanian
    Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, UK
    Hum Mol Genet 16:1445-53. 2007
  2. pmc Structural and molecular insights into the mechanism of action of human angiogenin-ALS variants in neurons
    Nethaji Thiyagarajan
    Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, UK
    Nat Commun 3:1121. 2012
  3. ncbi request reprint Human angiogenin is a neuroprotective factor and amyotrophic lateral sclerosis associated angiogenin variants affect neurite extension/pathfinding and survival of motor neurons
    Vasanta Subramanian
    Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, UK
    Hum Mol Genet 17:130-49. 2008
  4. pmc Ribonuclease A homologues of the zebrafish: polymorphism, crystal structures of two representatives and their evolutionary implications
    Konstantina Kazakou
    Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, UK
    J Mol Biol 380:206-22. 2008
  5. ncbi request reprint Biological and structural features of murine angiogenin-4, an angiogenic protein
    Benedict Crabtree
    Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, United Kingdom
    Biochemistry 46:2431-43. 2007
  6. ncbi request reprint Characterization of human angiogenin variants implicated in amyotrophic lateral sclerosis
    Benedict Crabtree
    Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, United Kingdom
    Biochemistry 46:11810-8. 2007
  7. pmc Structure of murine angiogenin: features of the substrate- and cell-binding regions and prospects for inhibitor-binding studies
    Daniel E Holloway
    Department of Biology and Biochemistry, University of Bath, England
    Acta Crystallogr D Biol Crystallogr 61:1568-78. 2005
  8. ncbi request reprint Behavior of endothelial cells on Matrigel and development of a method for a rapid and reproducible in vitro angiogenesis assay
    Benedict Crabtree
    Department of Biology and Biochemistry, University of Bath, Bath, BA2 7AY, UK
    In Vitro Cell Dev Biol Anim 43:87-94. 2007

Collaborators

  • K Ravi Acharya
  • Keith Brew
  • Robert Shapiro
  • Benedict Crabtree
  • Daniel E Holloway
  • Nethaji Thiyagarajan
  • Konstantina Kazakou
  • Stephen H Prior
  • Ross Ferguson
  • Peter Wilson
  • Shalini Iyer
  • Tyrone Ferns
  • Matthew D Baker
  • Michelle C Hares
  • Gayatri B Chavali

Detail Information

Publications8

  1. ncbi request reprint A new role for angiogenin in neurite growth and pathfinding: implications for amyotrophic lateral sclerosis
    Vasanta Subramanian
    Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, UK
    Hum Mol Genet 16:1445-53. 2007
    ..Our findings clearly show that ANG plays an important role in neurite pathfinding and this has implications for ALS...
  2. pmc Structural and molecular insights into the mechanism of action of human angiogenin-ALS variants in neurons
    Nethaji Thiyagarajan
    Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, UK
    Nat Commun 3:1121. 2012
    ..Our structure-function studies on these ANG-ALS variants are the first to provide insights into the cellular and molecular mechanisms underlying their role in ALS...
  3. ncbi request reprint Human angiogenin is a neuroprotective factor and amyotrophic lateral sclerosis associated angiogenin variants affect neurite extension/pathfinding and survival of motor neurons
    Vasanta Subramanian
    Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, UK
    Hum Mol Genet 17:130-49. 2008
    ..Our findings show that ANG plays an important role in neurite extension/pathfinding and survival providing a causal link between mutations in hANG and ALS...
  4. pmc Ribonuclease A homologues of the zebrafish: polymorphism, crystal structures of two representatives and their evolutionary implications
    Konstantina Kazakou
    Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, UK
    J Mol Biol 380:206-22. 2008
    ....
  5. ncbi request reprint Biological and structural features of murine angiogenin-4, an angiogenic protein
    Benedict Crabtree
    Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, United Kingdom
    Biochemistry 46:2431-43. 2007
    ..In the putative cell-binding segment, the replacement of Lys59 with Asn (its counterpart at position 61 of hAng) does not abrogate enzymatic activity but abolishes angiogenic activity, the reason for which is unclear...
  6. ncbi request reprint Characterization of human angiogenin variants implicated in amyotrophic lateral sclerosis
    Benedict Crabtree
    Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, United Kingdom
    Biochemistry 46:11810-8. 2007
    ..Our studies on the biochemical and structural features of these ANG variants now form the basis for further investigations to determine their role(s) in ALS...
  7. pmc Structure of murine angiogenin: features of the substrate- and cell-binding regions and prospects for inhibitor-binding studies
    Daniel E Holloway
    Department of Biology and Biochemistry, University of Bath, England
    Acta Crystallogr D Biol Crystallogr 61:1568-78. 2005
    ..These features represent considerable advantages over crystalline hAng and bAng...
  8. ncbi request reprint Behavior of endothelial cells on Matrigel and development of a method for a rapid and reproducible in vitro angiogenesis assay
    Benedict Crabtree
    Department of Biology and Biochemistry, University of Bath, Bath, BA2 7AY, UK
    In Vitro Cell Dev Biol Anim 43:87-94. 2007
    ..We also describe the differential behavior of normal and transformed endothelial cells cultured in Matrigel...