David I Strutt


Affiliation: University of Sheffield
Country: UK


  1. Strutt D, Madder D, Chaudhary V, Artymiuk P. Structure-function dissection of the frizzled receptor in Drosophila melanogaster suggests different mechanisms of action in planar polarity and canonical Wnt signaling. Genetics. 2012;192:1295-313 pubmed publisher
    ..These results support the view that qualitatively different Frizzled-Dishevelled interactions underlie planar polarity and canonical Wnt signaling. ..
  2. Strutt H, Langton P, Pearson N, McMillan K, Strutt D, Cullen P. Retromer Controls Planar Polarity Protein Levels and Asymmetric Localization at Intercellular Junctions. Curr Biol. 2019;29:484-491.e6 pubmed publisher
  3. Ressurreição M, Warrington S, Strutt D. Rapid Disruption of Dishevelled Activity Uncovers an Intercellular Role in Maintenance of Prickle in Core Planar Polarity Protein Complexes. Cell Rep. 2018;25:1415-1424.e6 pubmed publisher
    ..This release of Prickle generates a self-propagating wave of planar polarity complex destabilization across the tissue. Thus, Dishevelled actively maintains complex integrity across intercellular junctions. ..
  4. Strutt H, Strutt D. Planar polarity: forcing cells into line. Curr Biol. 2015;25:R1032-R1034 pubmed publisher
    ..Polarisation of tissues in the plane of an epithelium is fundamental for both animal morphogenesis and organ function. A new paper describes a role for mechanical cues in determining how such polarity is aligned with the body axes. ..
  5. request reprint
    Strutt D, Schnabel R, Fiedler F, Prömel S. Adhesion GPCRs Govern Polarity of Epithelia and Cell Migration. Handb Exp Pharmacol. 2016;234:249-274 pubmed
    ..Other adhesion GPCRs play essential roles in cell migration, indicating that this receptor class includes essential molecules for the control of various levels of cellular organisation. ..
  6. Strutt D. Gradients and the specification of planar polarity in the insect cuticle. Cold Spring Harb Perspect Biol. 2009;1:a000489 pubmed publisher
    ..More recent molecular genetic analyses in the fruit fly Drosophila have begun to give insights into the molecular nature of the gradients involved, and how they are interpreted at the cellular level. ..
  7. request reprint
    Strutt D. Asymmetric localization of frizzled and the establishment of cell polarity in the Drosophila wing. Mol Cell. 2001;7:367-75 pubmed
    ..This differential receptor distribution may represent a novel mechanism for amplifying small differences in signaling activity across the axis of a cell. ..
  8. request reprint
    Strutt D, Johnson R, Cooper K, Bray S. Asymmetric localization of frizzled and the determination of notch-dependent cell fate in the Drosophila eye. Curr Biol. 2002;12:813-24 pubmed
    ..This modulation may occur via direct interactions between Notch and Dishevelled. ..
  9. Strutt D, Strutt H. Differential activities of the core planar polarity proteins during Drosophila wing patterning. Dev Biol. 2007;302:181-94 pubmed

More Information


  1. Strutt D, Warrington S. Planar polarity genes in the Drosophila wing regulate the localisation of the FH3-domain protein Multiple Wing Hairs to control the site of hair production. Development. 2008;135:3103-11 pubmed publisher
    ..In addition, the distally localised core polarity protein Frizzled positively promotes prehair initiation, suggesting that both proximal and distal cellular cues act together to ensure accurate prehair placement. ..
  2. request reprint
    Strutt D, Mlodzik M. Hedgehog is an indirect regulator of morphogenetic furrow progression in the Drosophila eye disc. Development. 1997;124:3233-40 pubmed
    ..However, hh is required to promote furrow progression and regulate its rate of movement across the disc, since the furrow is significantly delayed in smo clones. ..
  3. request reprint
    Strutt D. Frizzled signalling and cell polarisation in Drosophila and vertebrates. Development. 2003;130:4501-13 pubmed
    ..This review discusses recent findings regarding non-canonical Frizzled signalling and cell polarisation. ..
  4. request reprint
    Strutt D. Organ shape: controlling oriented cell division. Curr Biol. 2005;15:R758-9 pubmed
    ..One mechanism by which organisms control the shape of growing organs is by regulating the orientation of cell divisions. This occurs in the Drosophila wing under the control of genes previously implicated in regulating cell polarity. ..
  5. Strutt H, Searle E, Thomas Macarthur V, Brookfield R, Strutt D. A Cul-3-BTB ubiquitylation pathway regulates junctional levels and asymmetry of core planar polarity proteins. Development. 2013;140:1693-702 pubmed publisher
    ..Loss of asymmetry by altered core protein levels can be explained by reference to feedback models for amplification of asymmetry. ..
  6. Strutt H, Gamage J, Strutt D. Robust Asymmetric Localization of Planar Polarity Proteins Is Associated with Organization into Signalosome-like Domains of Variable Stoichiometry. Cell Rep. 2016;17:2660-2671 pubmed publisher
  7. Warrington S, Strutt H, Fisher K, Strutt D. A Dual Function for Prickle in Regulating Frizzled Stability during Feedback-Dependent Amplification of Planar Polarity. Curr Biol. 2017;27:2784-2797.e3 pubmed publisher
    ..Overall, our approach reveals for the first time essential in vivo stabilizing and destabilizing interactions of the core proteins required for self-organization of planar polarity. ..