David I Strutt

Summary

Affiliation: University of Sheffield
Country: UK

Publications

  1. pmc A Cul-3-BTB ubiquitylation pathway regulates junctional levels and asymmetry of core planar polarity proteins
    Helen Strutt
    Department of Biomedical Science, University of Sheffield, Western Bank, Sheffield S10 2TN, UK
    Development 140:1693-702. 2013
  2. pmc Structure-function dissection of the frizzled receptor in Drosophila melanogaster suggests different mechanisms of action in planar polarity and canonical Wnt signaling
    David Strutt
    MRC Centre for Developmental and Biomedical Genetics, and Department of Biomedical Science, University of Sheffield, Sheffield, S10 2TN, United Kingdom
    Genetics 192:1295-313. 2012
  3. pmc Planar polarity specification through asymmetric subcellular localization of Fat and Dachsous
    Amy Brittle
    MRC Centre for Developmental and Biomedical Genetics, University of Sheffield, Western Bank, Sheffield, UK
    Curr Biol 22:907-14. 2012
  4. pmc Dynamics of core planar polarity protein turnover and stable assembly into discrete membrane subdomains
    Helen Strutt
    MRC Centre for Developmental and Biomedical Genetics, and Department of Biomedical Science, University of Sheffield, Western Bank, Sheffield S10 2TN, UK
    Dev Cell 20:511-25. 2011
  5. pmc Four-jointed modulates growth and planar polarity by reducing the affinity of dachsous for fat
    Amy L Brittle
    Medical Research Council MRC Centre for Developmental and Biomedical Genetics and Department of Biomedical Science, University of Sheffield, Sheffield S10 2TN, UK
    Curr Biol 20:803-10. 2010
  6. pmc Differential stability of flamingo protein complexes underlies the establishment of planar polarity
    Helen Strutt
    MRC Centre for Developmental and Biomedical Genetics and, Department of Biomedical Science, University of Sheffield, Western Bank, S10 2TN Sheffield, United Kingdom
    Curr Biol 18:1555-64. 2008
  7. pmc Differential activities of the core planar polarity proteins during Drosophila wing patterning
    David Strutt
    Centre for Developmental and Biomedical Genetics, Department of Biomedical Science, University of Sheffield, Western Bank, Sheffield, UK
    Dev Biol 302:181-94. 2007
  8. pmc Planar polarity genes in the Drosophila wing regulate the localisation of the FH3-domain protein Multiple Wing Hairs to control the site of hair production
    David Strutt
    MRC Centre for Developmental and Biomedical Genetics and Department of Biomedical Science, University of Sheffield, Western Bank, Sheffield S10 2TN, UK
    Development 135:3103-11. 2008
  9. pmc Gradients and the specification of planar polarity in the insect cuticle
    David Strutt
    MRC Centre for Developmental and Biomedical Genetics and Department of Biomedical Science, University of Sheffield, United Kingdom
    Cold Spring Harb Perspect Biol 1:a000489. 2009
  10. ncbi request reprint Organ shape: controlling oriented cell division
    David Strutt
    Centre for Developmental and Biomedical Genetics, Department of Biomedical Science, University of Sheffield, Sheffield S10 2TN, UK
    Curr Biol 15:R758-9. 2005

Collaborators

  • M Mlodzik
  • Helen Strutt
  • Amy Brittle
  • Amy L Brittle
  • Rosalind Brookfield
  • Victoria Thomas-Macarthur
  • Elizabeth Searle
  • Chloe Thomas
  • Samantha J Warrington
  • Ada Repiso
  • José Casal
  • Peter A Lawrence
  • M Fanto
  • M Boutros
  • U Weber
  • N Paricio

Detail Information

Publications21

  1. pmc A Cul-3-BTB ubiquitylation pathway regulates junctional levels and asymmetry of core planar polarity proteins
    Helen Strutt
    Department of Biomedical Science, University of Sheffield, Western Bank, Sheffield S10 2TN, UK
    Development 140:1693-702. 2013
    ..Loss of asymmetry by altered core protein levels can be explained by reference to feedback models for amplification of asymmetry...
  2. pmc Structure-function dissection of the frizzled receptor in Drosophila melanogaster suggests different mechanisms of action in planar polarity and canonical Wnt signaling
    David Strutt
    MRC Centre for Developmental and Biomedical Genetics, and Department of Biomedical Science, University of Sheffield, Sheffield, S10 2TN, United Kingdom
    Genetics 192:1295-313. 2012
    ..These results support the view that qualitatively different Frizzled-Dishevelled interactions underlie planar polarity and canonical Wnt signaling...
  3. pmc Planar polarity specification through asymmetric subcellular localization of Fat and Dachsous
    Amy Brittle
    MRC Centre for Developmental and Biomedical Genetics, University of Sheffield, Western Bank, Sheffield, UK
    Curr Biol 22:907-14. 2012
    ....
  4. pmc Dynamics of core planar polarity protein turnover and stable assembly into discrete membrane subdomains
    Helen Strutt
    MRC Centre for Developmental and Biomedical Genetics, and Department of Biomedical Science, University of Sheffield, Western Bank, Sheffield S10 2TN, UK
    Dev Cell 20:511-25. 2011
    ..Thus, we define the distinct roles of specific core proteins in the formation of asymmetric contacts between cells, which is a key event in the generation of coordinated cellular asymmetry...
  5. pmc Four-jointed modulates growth and planar polarity by reducing the affinity of dachsous for fat
    Amy L Brittle
    Medical Research Council MRC Centre for Developmental and Biomedical Genetics and Department of Biomedical Science, University of Sheffield, Sheffield S10 2TN, UK
    Curr Biol 20:803-10. 2010
    ....
  6. pmc Differential stability of flamingo protein complexes underlies the establishment of planar polarity
    Helen Strutt
    MRC Centre for Developmental and Biomedical Genetics and, Department of Biomedical Science, University of Sheffield, Western Bank, S10 2TN Sheffield, United Kingdom
    Curr Biol 18:1555-64. 2008
    ..The core polarity protein Flamingo (Fmi) localizes to both proximal and distal cell boundaries and is known to have asymmetric activity, but the molecular basis of this asymmetric activity is unknown...
  7. pmc Differential activities of the core planar polarity proteins during Drosophila wing patterning
    David Strutt
    Centre for Developmental and Biomedical Genetics, Department of Biomedical Science, University of Sheffield, Western Bank, Sheffield, UK
    Dev Biol 302:181-94. 2007
    ....
  8. pmc Planar polarity genes in the Drosophila wing regulate the localisation of the FH3-domain protein Multiple Wing Hairs to control the site of hair production
    David Strutt
    MRC Centre for Developmental and Biomedical Genetics and Department of Biomedical Science, University of Sheffield, Western Bank, Sheffield S10 2TN, UK
    Development 135:3103-11. 2008
    ..In addition, the distally localised core polarity protein Frizzled positively promotes prehair initiation, suggesting that both proximal and distal cellular cues act together to ensure accurate prehair placement...
  9. pmc Gradients and the specification of planar polarity in the insect cuticle
    David Strutt
    MRC Centre for Developmental and Biomedical Genetics and Department of Biomedical Science, University of Sheffield, United Kingdom
    Cold Spring Harb Perspect Biol 1:a000489. 2009
    ..More recent molecular genetic analyses in the fruit fly Drosophila have begun to give insights into the molecular nature of the gradients involved, and how they are interpreted at the cellular level...
  10. ncbi request reprint Organ shape: controlling oriented cell division
    David Strutt
    Centre for Developmental and Biomedical Genetics, Department of Biomedical Science, University of Sheffield, Sheffield S10 2TN, UK
    Curr Biol 15:R758-9. 2005
    ..One mechanism by which organisms control the shape of growing organs is by regulating the orientation of cell divisions. This occurs in the Drosophila wing under the control of genes previously implicated in regulating cell polarity...
  11. ncbi request reprint Frizzled signalling and cell polarisation in Drosophila and vertebrates
    David Strutt
    Centre for Developmental Genetics, Department of Biomedical Science, University of Sheffield, Western Bank, Sheffield S10 2TN, UK
    Development 130:4501-13. 2003
    ..This review discusses recent findings regarding non-canonical Frizzled signalling and cell polarisation...
  12. ncbi request reprint The asymmetric subcellular localisation of components of the planar polarity pathway
    David I Strutt
    Centre for Developmental Genetics, University of Sheffield School of Medicine and Biomedical Science, Alfred Denny Building, Western Bank, Sheffield S10 2TN, UK
    Semin Cell Dev Biol 13:225-31. 2002
    ..This review describes what is known about this phenomenon and its genetic control. Possible mechanisms for establishing asymmetric subcellular localisations, and its likely significance, are discussed...
  13. ncbi request reprint Hedgehog is an indirect regulator of morphogenetic furrow progression in the Drosophila eye disc
    D I Strutt
    Developmental Biology Programme, EMBL, Heidelberg, Germany
    Development 124:3233-40. 1997
    ..However, hh is required to promote furrow progression and regulate its rate of movement across the disc, since the furrow is significantly delayed in smo clones...
  14. ncbi request reprint Asymmetric localization of frizzled and the establishment of cell polarity in the Drosophila wing
    D I Strutt
    Centre for Developmental Genetics, Department of Biomedical Science, University of Sheffield, Western Bank, S10 2TN, Sheffield, United Kingdom
    Mol Cell 7:367-75. 2001
    ..This differential receptor distribution may represent a novel mechanism for amplifying small differences in signaling activity across the axis of a cell...
  15. ncbi request reprint Asymmetric localization of frizzled and the determination of notch-dependent cell fate in the Drosophila eye
    David Strutt
    Centre for Developmental Genetics, School of Medicine and Biomedical Science, University of Sheffield, Western Bank, S10 2TN, Sheffield, United Kingdom
    Curr Biol 12:813-24. 2002
    ..This decision is directed by the activity of the planar polarity genes, and, in particular, higher activity of the receptor Frizzled confers R3 fate...
  16. ncbi request reprint The role of RhoA in tissue polarity and Frizzled signalling
    D I Strutt
    Developmental Biology Programme, EMBL, Heidelberg, Germany
    Nature 387:292-5. 1997
    ..These data are consistent with a Fz/RhoA signalling cascade analogous to the yeast pheromone signalling pathway and that proposed for activation of the serum response factor (SRF) in vertebrate cells...
  17. ncbi request reprint Dishevelled activates JNK and discriminates between JNK pathways in planar polarity and wingless signaling
    M Boutros
    European Molecular Biology Laboratory, Developmental Biology Programme, Heidelberg, Germany
    Cell 94:109-18. 1998
    ..Our results indicate that different Wnt/Fz signals activate distinct intracellular pathways, and Dishevelled discriminates among them by distinct domain interactions...
  18. ncbi request reprint The regulation of hedgehog and decapentaplegic during Drosophila eye imaginal disc development
    D I Strutt
    Differentiation Programme, EMBL, Heidelberg, Germany
    Mech Dev 58:39-50. 1996
    ..We conclude that in the eye disc there are novel aspects to hedgehog pathway function. Moreover, engrailed does not play an essential conserved role...
  19. ncbi request reprint Ommatidial polarity in the Drosophila eye is determined by the direction of furrow progression and local interactions
    D I Strutt
    Differentiation Programme, EMBL, Heidelberg, Germany
    Development 121:4247-56. 1995
    ....
  20. ncbi request reprint Nuclear signaling by Rac and Rho GTPases is required in the establishment of epithelial planar polarity in the Drosophila eye
    M Fanto
    EMBL, Developmental Biology Programme, Heidelberg, Germany
    Curr Biol 10:979-88. 2000
    ..Thus far, analysis of Rac in this process has not been possible because of the absence of mutant Rac alleles. Here, we have investigated the role of Rac and Rho in establishing the polarity of ommatidia in the Drosophila eye...
  21. ncbi request reprint Regulation of furrow progression in the Drosophila eye by cAMP-dependent protein kinase A
    D I Strutt
    Differentiation Programme, EMBL, Heidelberg, Germany
    Nature 373:705-9. 1995
    ..Our results indicate that Pka-C1 lies in a signalling pathway that controls the orderly temporal progression of differentiation across the eye imaginal disc...