Allan Struthers

Summary

Affiliation: University of Dundee
Country: UK

Publications

  1. pmc Genetic variants predicting left ventricular hypertrophy in a diabetic population: a Go-DARTS study including meta-analysis
    Helen M Parry
    Division of Cardiovascular and Diabetes Medicine, University of Dundee, UK
    Cardiovasc Diabetol 12:109. 2013
  2. pmc Effect of high-dose allopurinol on exercise in patients with chronic stable angina: a randomised, placebo controlled crossover trial
    Awsan Noman
    Division of Medical Sciences, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK
    Lancet 375:2161-7. 2010
  3. pmc The accuracy of symptoms, signs and diagnostic tests in the diagnosis of left ventricular dysfunction in primary care: a diagnostic accuracy systematic review
    V Madhok
    Tayside Centre for General Practice, Division of Community Health Sciences, University of Dundee, Mackenzie Building, Dundee DD2 4BF, UK
    BMC Fam Pract 9:56. 2008
  4. pmc Does the aldosterone:renin ratio predict the efficacy of spironolactone over bendroflumethiazide in hypertension? A clinical trial protocol for RENALDO (RENin-ALDOsterone) study
    Hari K Parthasarathy
    Division of Medicine and Therapeutics, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK
    BMC Cardiovasc Disord 7:14. 2007
  5. ncbi request reprint Impact of aldosterone on vascular pathophysiology
    Allan D Struthers
    Department of Clinical Pharmacology and Therapeutics, Ninewells Hospital and Medical School, Dundee, Scotland, United Kingdom
    Congest Heart Fail 8:18-22. 2002
  6. pmc Effect of allopurinol on mortality and hospitalisations in chronic heart failure: a retrospective cohort study
    A D Struthers
    Department of Clinical Pharmacology and Therapeutics, and the Medicines Monitoring Unit, Ninewells Hospital, Dundee DD1 9SY, UK
    Heart 87:229-34. 2002
  7. ncbi request reprint Screening for and treating left-ventricular abnormalities in diabetes mellitus: a new way of reducing cardiac deaths
    Allan D Struthers
    Department of Clinical Pharmacology, Ninewells Hospital and Medical School, DD1 9SY, Dundee, UK
    Lancet 359:1430-2. 2002
  8. pmc Angiotensin blockade or aldosterone blockade as the third neuroendocrine-blocking drug in mild but symptomatic heart failure patients
    A D Struthers
    Division of Medicine and Therapeutics, Ninewells Hospital, Dundee DD1 9SY, UK
    Heart 92:1728-31. 2006
  9. ncbi request reprint Aldosterone in heart failure: pathophysiology and treatment
    Allan D Struthers
    Division of Medicine and Therapeutics, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
    Curr Heart Fail Rep 1:171-5. 2004
  10. pmc Pathophysiology of heart failure following myocardial infarction
    A D Struthers
    Division of Medicine and Therapeutics, Ninewells Hospital, Dundee DD1 9SY, UK
    Heart 91:ii14-6; discussion ii31, ii43-8. 2005

Collaborators

Detail Information

Publications124 found, 100 shown here

  1. pmc Genetic variants predicting left ventricular hypertrophy in a diabetic population: a Go-DARTS study including meta-analysis
    Helen M Parry
    Division of Cardiovascular and Diabetes Medicine, University of Dundee, UK
    Cardiovasc Diabetol 12:109. 2013
    ..Left ventricular hypertrophy has multiple aetiologies including diabetes and genetic factors. We aimed to identify genetic variants predicting left ventricular hypertrophy in diabetic individuals...
  2. pmc Effect of high-dose allopurinol on exercise in patients with chronic stable angina: a randomised, placebo controlled crossover trial
    Awsan Noman
    Division of Medical Sciences, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK
    Lancet 375:2161-7. 2010
    ..We ascertained whether high-dose allopurinol prolongs exercise capability in patients with chronic stable angina...
  3. pmc The accuracy of symptoms, signs and diagnostic tests in the diagnosis of left ventricular dysfunction in primary care: a diagnostic accuracy systematic review
    V Madhok
    Tayside Centre for General Practice, Division of Community Health Sciences, University of Dundee, Mackenzie Building, Dundee DD2 4BF, UK
    BMC Fam Pract 9:56. 2008
    ..To assess the accuracy of findings from the clinical history, symptoms, signs and diagnostic tests (ECG, CXR and natriuretic peptides) in relation to the diagnosis of left ventricular systolic dysfunction (LVSD) in a primary care setting...
  4. pmc Does the aldosterone:renin ratio predict the efficacy of spironolactone over bendroflumethiazide in hypertension? A clinical trial protocol for RENALDO (RENin-ALDOsterone) study
    Hari K Parthasarathy
    Division of Medicine and Therapeutics, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK
    BMC Cardiovasc Disord 7:14. 2007
    ....
  5. ncbi request reprint Impact of aldosterone on vascular pathophysiology
    Allan D Struthers
    Department of Clinical Pharmacology and Therapeutics, Ninewells Hospital and Medical School, Dundee, Scotland, United Kingdom
    Congest Heart Fail 8:18-22. 2002
    ..The term "aldosterone vasculopathy" has been coined to describe that the fundamentally adverse effect of aldosterone may well be on endothelial nitric oxide...
  6. pmc Effect of allopurinol on mortality and hospitalisations in chronic heart failure: a retrospective cohort study
    A D Struthers
    Department of Clinical Pharmacology and Therapeutics, and the Medicines Monitoring Unit, Ninewells Hospital, Dundee DD1 9SY, UK
    Heart 87:229-34. 2002
    ..This hypothesis is based on previous data that a high urate concentration is independently associated with mortality with a risk ratio of 4.23 in CHF...
  7. ncbi request reprint Screening for and treating left-ventricular abnormalities in diabetes mellitus: a new way of reducing cardiac deaths
    Allan D Struthers
    Department of Clinical Pharmacology, Ninewells Hospital and Medical School, DD1 9SY, Dundee, UK
    Lancet 359:1430-2. 2002
  8. pmc Angiotensin blockade or aldosterone blockade as the third neuroendocrine-blocking drug in mild but symptomatic heart failure patients
    A D Struthers
    Division of Medicine and Therapeutics, Ninewells Hospital, Dundee DD1 9SY, UK
    Heart 92:1728-31. 2006
    ..Clinicians should now assess these various arguments to select what they believe would be best for their patients...
  9. ncbi request reprint Aldosterone in heart failure: pathophysiology and treatment
    Allan D Struthers
    Division of Medicine and Therapeutics, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
    Curr Heart Fail Rep 1:171-5. 2004
    ..Aldosterone blockade should become a regular third neuroendocrine-blocking drug in patients with chronic heart failure...
  10. pmc Pathophysiology of heart failure following myocardial infarction
    A D Struthers
    Division of Medicine and Therapeutics, Ninewells Hospital, Dundee DD1 9SY, UK
    Heart 91:ii14-6; discussion ii31, ii43-8. 2005
    ..The increased understanding of the mechanistic role of aldosterone in cardiovascular disease provides a rationale for the positive results that have been seen in clinical trials of aldosterone blockade...
  11. ncbi request reprint Aldosterone blockade in heart failure
    Allan D Struthers
    Division of Medicine and Therapeutics, Ninewells Hospital and Medical School, Dundee, DD1 9SY, UK
    J Renin Angiotensin Aldosterone Syst 5:S23-7. 2004
    ..87. The reduction in the risk of sudden death from cardiac causes was statistically significant. In conclusion, aldosterone blockade should form part of optimal therapy for patients with heart failure...
  12. ncbi request reprint Aldosterone: cardiovascular assault
    Allan D Struthers
    Department of Clinical Pharmacology and Therapeutics, Ninewells Hospital and Medical School, Dundee, Scotland
    Am Heart J 144:S2-7. 2002
    ..However, because of aldosterone "escape," the effectiveness of this blockade decreases over time...
  13. ncbi request reprint Review of aldosterone- and angiotensin II-induced target organ damage and prevention
    Allan D Struthers
    Department of Clinical Pharmacology and Therapeutics, Ninewells Hospital and Medical School, Tayside DD1 9SY, Dundee, UK
    Cardiovasc Res 61:663-70. 2004
    ....
  14. ncbi request reprint Should we add screening for and treating left ventricular hypertrophy to the management of all patients needing secondary prevention of cardiovascular disease?
    A D Struthers
    Department of Clinical Pharmacology and Therapeutics, Ninewells Hospital, Dundee, UK
    QJM 96:449-52. 2003
  15. pmc Aldosterone blockade in cardiovascular disease
    Allan D Struthers
    Division of Medicine and Therapeutics, Ninewells Hospital and Medical School, Dundee, DD1 9SY, UK
    Heart 90:1229-34. 2004
  16. ncbi request reprint B-type natriuretic peptide: a simple new test to identify coronary artery disease?
    A D Struthers
    Division of Medicine and Therapeutics, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
    QJM 98:765-9. 2005
    ..We review the evidence for this new prospect, which has the potential to reduce cardiac deaths by using a simple blood test to better target cardioprotective strategies to those who most need them...
  17. doi request reprint A comparison of the aldosterone-blocking agents eplerenone and spironolactone
    Allan Struthers
    Division of Medicine and Therapeutics, Ninewells Hospital and Medical School, Dundee, UK
    Clin Cardiol 31:153-8. 2008
    ..Choice of a specific agent should be based on individual patient issues, such as the nature of heart failure and patient concerns about adverse events...
  18. ncbi request reprint Careful screening to target interventions to prevent sudden cardiac death
    A D Struthers
    Department of Clinical Pharmacology and Therapeutics, Ninewells Hospital, Dundee, United Kingdom
    Clin Exp Pharmacol Physiol 28:219-22. 2001
    ..4. Once individuals are identified as being at high risk, a range of interventions is possible (e.g. intensive statin therapy or angiotensin-converting enzyme inhibitors if LV abnormalities or autonomic imbalance are found)...
  19. ncbi request reprint The potential to improve primary prevention in the future by using BNP/N-BNP as an indicator of silent 'pancardiac' target organ damage: BNP/N-BNP could become for the heart what microalbuminuria is for the kidney
    Allan Struthers
    Division of Medicine and Therapeutics, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK
    Eur Heart J 28:1678-82. 2007
    ..BNP/N-BNP could become to the heart what microalbuminuria is to the kidneys, i.e. an indicator of early, silent TOD...
  20. ncbi request reprint The clinical implications of aldosterone escape in congestive heart failure
    Allan D Struthers
    Division of Medicine and Therapeutics, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
    Eur J Heart Fail 6:539-45. 2004
    ..Inhibition of aldosterone's effect on mineralocorticoid receptors should now be considered standard therapy in these patient populations...
  21. pmc Allopurinol reduces B-type natriuretic peptide concentrations and haemoglobin but does not alter exercise capacity in chronic heart failure
    A D Gavin
    Division of Medicine and Therapeutics, Ninewells Hospital and Medical School, Dundee, UK
    Heart 91:749-53. 2005
    ....
  22. doi request reprint Spironolactone for poorly controlled hypertension in type 2 diabetes: conflicting effects on blood pressure, endothelial function, glycaemic control and hormonal profiles
    K Swaminathan
    Division of Medicine and Therapeutics, Ninewells Hospital and Medical School, Dundee, DD1 9SY, UK
    Diabetologia 51:762-8. 2008
    ..We therefore assessed the full effects of aldosterone blockade in poorly controlled hypertensive patients with type 2 diabetes, focussing on blood pressure, endothelial function, glycaemic control and key hormones...
  23. ncbi request reprint High-dose allopurinol improves endothelial function by profoundly reducing vascular oxidative stress and not by lowering uric acid
    Jacob George
    Division of Medicine and Therapeutics, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
    Circulation 114:2508-16. 2006
    ..Allopurinol has been shown to improve endothelial function in chronic heart failure. This study aimed to establish its mechanism of action and to construct a dose-response curve for the effect of allopurinol...
  24. pmc Effects of spironolactone on endothelial function, vascular angiotensin converting enzyme activity, and other prognostic markers in patients with mild heart failure already taking optimal treatment
    J E Macdonald
    Department of Clinical Pharmacology and Therapeutics, Ninewells Hospital and Medical School, Dundee DD19SY, UK
    Heart 90:765-70. 2004
    ....
  25. ncbi request reprint Aldosterone blockade over and above ACE-inhibitors in patients with coronary artery disease but without heart failure
    Nimit C Shah
    Department of Medicine and Therapeutics, Ninewells Hospital, Dundee, UK
    J Renin Angiotensin Aldosterone Syst 7:20-30. 2006
    ..Finally, aldosterone blockade has been shown to reduce atherosclerosis in animal studies of atherosclerosis without heart failure, which are analogous to CAD patients...
  26. pmc Increasing plasma potassium with amiloride shortens the QT interval and reduces ventricular extrasystoles but does not change endothelial function or heart rate variability in chronic heart failure
    C A J Farquharson
    University Department of Clinical Pharmacology and Therapeutics, Ninewells Hospital and Medical School, Dundee, UK
    Heart 88:475-80. 2002
    ....
  27. ncbi request reprint Lisinopril improves endothelial function in chronic cigarette smokers
    R Butler
    University Department of Clinical Pharmacology and Therapeutics, Ninewells Hospital and Medical School, Dundee DD1 9SY, Scotland, U K
    Clin Sci (Lond) 101:53-8. 2001
    ..The mechanism could be either that lisinopril limits the angiotensin II-induced production of superoxide radicals which would normally inactivate NO, or that lisinopril may increase bradykinin-mediated NO release...
  28. pmc A placebo-controlled study examining the effect of allopurinol on heart rate variability and dysrhythmia counts in chronic heart failure
    A M Shehab
    Cardiovascular Research Group, Department of Clinical Pharmacology and Therapeutics, Ninewells Hospital and Medical School, Dundee, United Kingdom
    Br J Clin Pharmacol 51:329-34. 2001
    ..Allopurinol improves endothelial function in chronic heart failure by reducing oxidative stress. We wished to explore if such an effect would attenuate autonomic dysfunction in CHF in line with many other effective therapies in CHF...
  29. ncbi request reprint Circadian variation in the effects of aldosterone blockade on heart rate variability and QT dispersion in congestive heart failure
    K M Yee
    University Department of Clinical Pharmacology and Therapeutics, Ninewells Hospital and Medical School, Dundee, United Kingdom
    J Am Coll Cardiol 37:1800-7. 2001
    ..CONCLUSIONS: Spironolactone reduced heart rate and improved HRV and QT dispersion in CHF. Its effects were particularly prominent during the morning hours...
  30. ncbi request reprint Gradual reactivation of vascular angiotensin I to angiotensin II conversion during chronic ACE inhibitor therapy in patients with diabetes mellitus
    D C Sharman
    Division of Medicine and Therapeutics, University of Dundee, Ninewells Hospital and Medical School, Dundee, DD1 9SY, UK
    Diabetologia 50:2061-6. 2007
    ..However, it remains unknown whether the same overall phenomenon occurs in other patients taking chronic ACE inhibitor therapy, such as patients with type 2 diabetes mellitus...
  31. pmc Cigarette smoking in men and vascular responsiveness
    R Butler
    University Department of Clinical Pharmacology and Therapeutics, Ninewells Hospital and Medical School, Dundee, UK
    Br J Clin Pharmacol 52:145-9. 2001
    ..Endothelial independent vasodilator responses (to nitroprusside and verapamil) were unaltered in smokers. A defect in the vasoconstrictor response to angiotensin I was also seen...
  32. ncbi request reprint The potential benefits of aldosterone antagonism in Type 2 diabetes mellitus
    Justine Davies
    Department of Clinical Pharmacology, Ninewells Hospital and Medical School, Dundee, DD1 9SY, UK
    J Renin Angiotensin Aldosterone Syst 3:150-5. 2002
    ..Since inhibition of the RAAS at the level of ACE is now seen to be an important therapy in diabetes; the purpose of this article is to explore the potential benefits of additional aldosterone inhibition in Type 2 diabetes mellitus...
  33. ncbi request reprint Do losartan and atenolol have differential effects on BNP and central haemodynamic parameters?
    Justine Davies
    Division of Medicine and Therapeutics, Ninewells Hospital and Medical School, Dundee, DD1 9SY, UK
    J Renin Angiotensin Aldosterone Syst 6:151-3. 2005
    ..We aimed to investigate if this was the case with losartan when compared to atenolol. We also investigated the differential effect of losartan and atenolol on the prognostic marker, brain type natriuretic peptide (BNP)...
  34. ncbi request reprint The functional consequence of the Glu298Asp polymorphism of the endothelial nitric oxide synthase gene in young healthy volunteers
    Valerie Godfrey
    Division of Medicine and Therapeutics, University of Dundee, Dundee, UK
    Cardiovasc Drug Rev 25:280-8. 2007
    ....
  35. pmc Ovarian hormones in man: their effects on resting vascular tone, angiotensin converting enzyme activity and angiotensin II-induced vasoconstriction
    A F Lee
    Department of Clinical Pharmacology, Ninewells Hospital and Medical School, Dundee
    Br J Clin Pharmacol 50:73-6. 2000
    ..The aim of this study was to assess the effect of ovarian hormones on vascular tone, vascular ACE activity and vasoconstriction to angiotensin II in males...
  36. pmc QT interval abnormalities are often present at diagnosis in diabetes and are better predictors of cardiac death than ankle brachial pressure index and autonomic function tests
    B S Rana
    Department of Clinical Pharmacology and Therapeutics, University of Dundee, Ninewells Hospital, Dundee DD1 9SY, UK
    Heart 91:44-50. 2005
    ....
  37. ncbi request reprint DD angiotensin-converting enzyme gene polymorphism is associated with endothelial dysfunction in normal humans
    R Butler
    University Department of Clinical Pharmacology, Ninewells Hospital and Medical School, Dundee, UK
    Hypertension 33:1164-8. 1999
    ..These data demonstrate that the DD ACE genotype in a young population is associated with a blunting of stimulated endothelial NO and donated NO responses but not to non-NO vasodilators or vasoconstrictors...
  38. ncbi request reprint Hypothetical economic analysis of screening for left ventricular hypertrophy in high-risk normotensive populations
    M D Witham
    Section of Ageing and Health, Ninewells Hospital and Medical School, Dundee, UK
    QJM 97:87-93. 2004
    ..The prevalence of echocardiographic LVH in patients with high cardiovascular risk appears to be high, even in patients currently considered normotensive...
  39. doi request reprint The electrocardiogram is an unreliable method of identifying left ventricular hypertrophy in stable, treated angina patients
    D S C Ang
    Division of Medicine and Therapeutics, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK
    J Hum Hypertens 22:394-400. 2008
    ..This will enable intensified efforts to ensure LVH regression, which is associated with reduction in both cardiovascular morbidity and mortality...
  40. ncbi request reprint Cardiovascular autonomic function in patients with hemodynamic instability at induction of capnoperitoneum: a case-control study
    A Alijani
    Department of Surgery, Ninewells Hospital and Medical School, DD1 9SY, Dundee, Scotland, UK
    Surg Endosc 18:915-8. 2004
    ..This study hypothesized that patients in whom bradycardia and hypotension develop with induction of positive-pressure capnoperitoneum have an underlying autonomic cardiovascular dysfunction...
  41. ncbi request reprint Adverse cardiac effects of salt with fludrocortisone in hypertension
    P O Lim
    Hypertension Research Center, Department of Clinical Pharmacology and Therapeutics, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
    Hypertension 37:856-61. 2001
    ..This raises the possibility that salt may have BP-independent adverse cardiac effects in susceptible hypertensive subjects...
  42. ncbi request reprint Spironolactone impairs endothelial function and heart rate variability in patients with type 2 diabetes
    J I Davies
    Division of Medicine and Therapeutics, Ninewells Hospital and Medical School, Dundee, Scotland
    Diabetologia 47:1687-94. 2004
    ..We postulated that aldosterone blockade with spironolactone might also have beneficial effects on the prognostic markers of endothelial function and heart rate variability in diabetic patients...
  43. pmc Spectrum of cardiac abnormalities associated with long QT in stroke survivors
    K Y K Wong
    Division of Medicine and Therapeutics, University of Dundee, Dundee, UK
    Heart 91:1306-10. 2005
    ..To find out what spectrum of cardiac abnormalities are found in those stroke survivors who can be deemed to be at high cardiac risk by their having long QT...
  44. pmc B-type natriuretic peptide can detect silent myocardial ischaemia in asymptomatic type 2 diabetes
    B S Rana
    Division of Medicine and Therapeutics, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK
    Heart 92:916-20. 2006
    ..To find out whether B-type natriuretic peptide (BNP) detects silent myocardial ischaemia in patients with type 2 diabetes, since many of these patients have silent ischaemia leading to unexpected cardiac deaths...
  45. doi request reprint The effect of different doses of vitamin D(3) on markers of vascular health in patients with type 2 diabetes: a randomised controlled trial
    M D Witham
    Ageing and Health, Ninewells Hospital, Dundee DD1 9SY, UK
    Diabetologia 53:2112-9. 2010
    ..We compared the effect of 100,000 and 200,000 IU doses of vitamin D(3) on endothelial function, blood pressure and markers of glycaemic control in patients with type 2 diabetes...
  46. doi request reprint Vitamin D improves endothelial function in patients with Type 2 diabetes mellitus and low vitamin D levels
    J A Sugden
    Department of Clinical Pharmacology, Division of Medicine and Therapeutics, Ninewells Hospital and Medical School, Dundee, UK
    Diabet Med 25:320-5. 2008
    ..To test whether a single large dose of vitamin D2 can improve endothelial function in patients with Type 2 diabetes mellitus and low serum 25-hydroxyvitamin D levels...
  47. ncbi request reprint The epidemiology of left ventricular hypertrophy in type 2 diabetes mellitus
    A Dawson
    Division of Medicine and Therapeutics, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
    Diabetologia 48:1971-9. 2005
    ..Although it is widely acknowledged that diabetes is a risk factor for coronary artery disease, the increased prevalence of potentially lethal left ventricular abnormalities in this population is less well appreciated...
  48. doi request reprint Oxidative stress in renal dysfunction: mechanisms, clinical sequelae and therapeutic options
    M P C Kao
    Division of Medical Sciences, Centre for Cardiovascular and Lung Biology, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
    J Hum Hypertens 24:1-8. 2010
    ....
  49. ncbi request reprint Does a prolonged QT peak identify left ventricular hypertrophy in hypertension?
    K Y K Wong
    The Cardiovascular Research Group, Ninewells Hospital, Dundee, UK
    Int J Cardiol 89:179-86. 2003
    ..start of QRS to peak of T wave) is easier to measure. Therefore, we tested the hypothesis that long QT peak was associated with left ventricular hypertrophy and assessed its cost-effectiveness at diagnosing left ventricular hypertrophy...
  50. ncbi request reprint Spironolactone increases nitric oxide bioactivity, improves endothelial vasodilator dysfunction, and suppresses vascular angiotensin I/angiotensin II conversion in patients with chronic heart failure
    C A Farquharson
    University Department of Clinical Pharmacology and Therapeutics, Ninewells Hospital and Medical School, Dundee, UK
    Circulation 101:594-7. 2000
    ..We tested the hypothesis that this benefit was partially due to improvement in endothelial function and/or to amplified suppression of the vascular renin-angiotensin axis...
  51. pmc Is there a role for renin profiling in selecting chronic heart failure patients for ACE inhibitor treatment?
    P O Lim
    Cardiovascular Research Group, Department of Clinical Pharmacology and Therapeutics, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
    Heart 83:257-61. 2000
    ..It remains uncertain whether angiotensin converting enzyme (ACE) inhibitors benefit all heart failure patients or just those with renin-angiotensin-aldosterone system (RAAS) activation...
  52. pmc QT dispersion in patients with chronic heart failure: beta blockers are associated with a reduction in QT dispersion
    C E Bonnar
    Department of Clinical Pharmacology and Therapeutics, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
    Heart 81:297-302. 1999
    ..To compare QT dispersion in patients with impaired left ventricular systolic function and in matched control patients with normal left ventricular systolic function...
  53. ncbi request reprint Irbesartan reduces QT dispersion in hypertensive individuals
    P O Lim
    Hypertension Research Centre, Department of Clinical Pharmacology and Therapeutics, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK
    Hypertension 33:713-8. 1999
    ..In conclusion, irbesartan improved QT dispersion, and this effect may be important in preventing sudden cardiac death in at-risk hypertensive subjects...
  54. ncbi request reprint Aldosterone blockade reduces vascular collagen turnover, improves heart rate variability and reduces early morning rise in heart rate in heart failure patients
    R J MacFadyen
    Department of Clinical Pharmacology, University of Dundee, Ninewells Hospital and Medical School, UK
    Cardiovasc Res 35:30-4. 1997
    ..Experimental data suggest that aldosterone has harmful effects promoting myocardial fibrosis and disturbing autonomic balance. There has been no evidence of these potential effects in intact man...
  55. ncbi request reprint Effects of xamoterol in acute myocardial infarction: blood pressure, heart rate, arrhythmias and early clinical course
    J McMurray
    Department of Clinical Pharmacology, Ninewells Hospital and Medical School, Dundee, U K
    Int J Cardiol 31:295-303. 1991
    ..One patient treated with placebo developed new heart failure. These results show that xamoterol can be administered safely to selected patients following myocardial infarction, including those treated for mild heart failure...
  56. pmc The prognostic value of high sensitivity troponin T 7 weeks after an acute coronary syndrome
    Donald S C Ang
    Centre for Cardiovascular and Lung Biology, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK
    Heart 98:1160-5. 2012
    ..Third, the authors assessed whether the prognostic utility of hs-TnT is independent of various echocardiographic abnormalities...
  57. doi request reprint Serial changes in adiponectin and BNP in ACS patients: paradoxical associations with each other and with prognosis
    Donald S C Ang
    Division of Medicine and Therapeutics, Ninewells Hospital and Medical School, Dundee, Scotland, UK
    Clin Sci (Lond) 117:41-8. 2009
    ..The results of the present study allude to a potential direct or indirect relationship between adiponectin and BNP post-ACS which requires further investigation...
  58. ncbi request reprint Reversible hypertension following coeliac disease treatment: the role of moderate hyperhomocysteinaemia and vascular endothelial dysfunction
    P O Lim
    Hypertension Research Centre, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
    J Hum Hypertens 16:411-5. 2002
    ..This highlights the need to resolve co-existing vascular risk factors in patients with hypertension...
  59. pmc B-type natriuretic peptide identifies silent myocardial ischaemia in stroke survivors
    K Y K Wong
    Division of Medicine and Therapeutics, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK
    Heart 92:487-9. 2006
    ..To test the hypothesis that B-type natriuretic peptide (BNP) predicts reversible myocardial ischaemia in stroke survivors who do not have chest pain or previous myocardial infarction...
  60. pmc How often are angiotensin II and aldosterone concentrations raised during chronic ACE inhibitor treatment in cardiac failure?
    R J MacFadyen
    Departments of Clinical Pharmacology and Cardiology, Cardiovascular Research Group, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, UK
    Heart 82:57-61. 1999
    ..In congestive heart failure (CHF) such failure of hormonal suppression is associated with increased mortality. This study examined how common AII and aldosterone increases are observed during routine clinical practice...
  61. ncbi request reprint Diagnosis of left ventricular systolic dysfunction (LVSD): development and validation of a clinical prediction rule in primary care
    T Fahey
    Division of Community Health Sciences, University of Dundee, Mackenzie Building, Dundee DD2 4BF, UK
    Fam Pract 24:628-35. 2007
    ..Diagnosing suspected left ventricular systolic dysfunction (LVSD) in the community is a challenge for GPs. We developed and validated a clinical prediction rule (CPR) for LVSD based on history, examination and electrocardiogram (ECG)...
  62. ncbi request reprint Urate predicts subsequent cardiac death in stroke survivors
    K Y K Wong
    The Cardiovascular Research Group, Department of Clinical Pharmacology and Therapeutics, University of Dundee Medical School, Dundee, UK
    Eur Heart J 23:788-93. 2002
    ..To test the hypothesis that urate predicts cardiac death after stroke independent of conventional risk factors of atherosclerosis, creatinine and diuretic use...
  63. doi request reprint Association between allopurinol and mortality in heart failure patients: a long-term follow-up study
    L Wei
    Medicines Monitoring Unit MEMO, Division of Medicine and Therapeutics, Ninewells Hospital and Medical School, Dundee, UK
    Int J Clin Pract 63:1327-33. 2009
    ..The aim of the study was to explore the long-term effect of allopurinol on mortality and cardiovascular hospitalisations in heart failure (HF) patients...
  64. pmc Global array-based transcriptomics from minimal input RNA utilising an optimal RNA isolation process combined with SPIA cDNA probes
    Laura Kennedy
    Translational Medicine Research Collaboration, TMRC Laboratory, Ninewells Hospital, Dundee, United Kingdom
    PLoS ONE 6:e17625. 2011
    ..These workflows provide the ability to robustly exploit ever more common clinical samples yielding extremely low cell numbers and RNA yields for global transcriptomics...
  65. doi request reprint Left ventricular hypertrophy: reduction of blood pressure already in the normal range further regresses left ventricular mass
    H J Simpson
    Division of Medical Sciences, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
    Heart 96:148-52. 2010
    ..Regression of LVH reduces risk. Patients with blood pressure in the normal range and LVH are common. We investigated whether further reduction in blood pressure would further regress LVH...
  66. ncbi request reprint Effect of social deprivation on mortality and the duration of hospital stay after a stroke
    K Y K Wong
    Department of Clinical Pharmacology and Therapeutics, Ninewells Hospital Dundee, Dundee, UK
    Cerebrovasc Dis 22:251-7. 2006
    ..We aim to assess whether social deprivation independently predicts case fatality after a stroke patient has been admitted to hospital, and to assess whether social deprivation affected duration of hospital stay...
  67. ncbi request reprint Hypokalemic and ECG sequelae of combined beta-agonist/diuretic therapy. Protection by conventional doses of spironolactone but not triamterene
    B J Lipworth
    Department of Clinical Pharmacology, Ninewells Hospital, Dundee, Scotland
    Chest 98:811-5. 1990
    ..These findings may be important in the prevention of a potentially dangerous interaction in susceptible patients taking this combination of drugs...
  68. pmc Adherence to statin treatment and readmission of patients after myocardial infarction: a six year follow up study
    L Wei
    Medicines Monitoring Unit, Department of Clinical Pharmacology and Therapeutics, Ninewells Hospital and Medical School, Dundee, UK
    Heart 88:229-33. 2002
    ..To investigate patients' adherence to statin treatment prescribed following their first myocardial infarction (MI) and to estimate the effect of adherence to statins on recurrence of MI and all cause mortality...
  69. ncbi request reprint Neuroendocrine changes post myocardial infarction: effects of xamoterol
    J J McMurray
    Department of Clinical Pharmacology, Ninewells Hospital, Dundee, Scotland
    Am Heart J 120:56-62. 1990
    ..We conclude that xamoterol does not cause deleterious neuroendocrine changes in patients with AMI even in those treated for heart failure...
  70. pmc Perindopril improves six minute walking distance in older patients with left ventricular systolic dysfunction: a randomised double blind placebo controlled trial
    S D Hutcheon
    Section of Ageing and Health, Department of Medicine, University of Dundee, Ninewells Hospital, Dundee, UK
    Heart 88:373-7. 2002
    ..To evaluate the effects of the angiotensin converting enzyme inhibitor perindopril on six minute walking distance and quality of life in very old patients with left ventricular systolic dysfunction...
  71. ncbi request reprint Comparison of two methods of determining renal perfusion with and without captopril pretreatment in groups of patients with left ventricular dysfunction
    J G Motwani
    Department of Clinical Pharmacology, Ninewells Hospital and Medical School, Dundee, Scotland, U K
    Eur Heart J 15:226-31. 1994
    ..05). This reversed association and the weaker relationships between methods in post-infarction as compared to chronic heart failure patients may be related to interference by thrombolytic or aspirin treatments...
  72. pmc The role of urate and xanthine oxidase in vascular oxidative stress: future directions
    Jacob George
    Division of Medicine and Therapeutics, Ninewells Hospital and Medical School, Dundee, UK
    Ther Clin Risk Manag 5:799-803. 2009
    ....
  73. ncbi request reprint Electrocardiographic changes induced by inhaled salbutamol after treatment with bendrofluazide: effects of replacement therapy with potassium, magnesium and triamterene
    B J Lipworth
    Department of Clinical Pharmacology, Ninewells Hospital and Medical School, Dundee, Scotland, U K
    Clin Sci (Lond) 78:255-9. 1990
    ..Supplementation with potassium and magnesium had no effect on electrocardiographic changes, and the addition of triamterene to bendrofluazide only attenuated electrocardiographic responses in some subjects...
  74. pmc Sudden unexpected death in heart failure may be preceded by short term, intraindividual increases in inflammation and in autonomic dysfunction: a pilot study
    A M A Shehab
    Department of Clinical Pharmacology and Therapeutics, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
    Heart 90:1263-8. 2004
    ..To see whether sudden unexpected death in chronic heart failure is preceded by intraindividual worsening in inflammation and in ECG criteria...
  75. pmc Long QTc predicts future cardiac death in stroke survivors
    K Y K Wong
    The Cardiovascular Research Group, Department of Clinical Pharmacology and Therapeutics, University of Dundee Medical School, Ninewells Hospital, Dundee, UK
    Heart 89:377-81. 2003
    ..To test the hypothesis that the QTc of any lead of the ECG predicts death after stroke, and to determine which lead of the ECG carries the greatest risk of cardiac death when its QTc is measured...
  76. ncbi request reprint Can drug effects on mortality in heart failure be predicted by any surrogate measure?
    K M Yee
    Department of Clinical Pharmacology, Ninewells Hospital and Medical School, Dundee, UK
    Eur Heart J 18:1860-4. 1997
    ..The most promising surrogates are heart rate variability, QT dispersion and plasma neurohormones, the first two for sudden death and the last one for death from progressive disease...
  77. doi request reprint A comparison between B-type natriuretic peptide, global registry of acute coronary events (GRACE) score and their combination in ACS risk stratification
    D S C Ang
    Division of Medicine and Therapeutics, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
    Heart 95:1836-42. 2009
    ..However, it is unknown how BNP compares with GRACE and how their combination performs in ACS...
  78. pmc Screening for left ventricular systolic dysfunction using GP-reported ECGs
    Barclay M Goudie
    Westgate Health Centre, Dundee, UK
    Br J Gen Pract 57:191-5. 2007
    ..Pre-echocardiography screening with electrocardiograms (ECGs) is recommended as a means of targeting this scarce resource. There are data to support this policy when ECGs are interpreted by cardiologists but not by GPs...
  79. ncbi request reprint Heart failure in frail elderly patients: diagnostic difficulties, co-morbidities, polypharmacy and treatment dilemmas
    Christopher T C Lien
    Ageing and Health, Department of Medicine, Ninewells Hospital and Medical School, DD1 9SY, Dundee, UK
    Eur J Heart Fail 4:91-8. 2002
    ..Symptoms may be non-specific and the presence of co-morbidities and polypharmacy complicate treatment strategies. There are, however, few data to quantify the extent of these problems in the very elderly...
  80. ncbi request reprint Left ventricular hypertrophy is present in one-half of newly-diagnosed peripheral arterial disease patients
    Gary A Wright
    Division of Medicine and Therapeutics, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
    J Hypertens 25:463-9. 2007
    ..Peripheral arterial disease (PAD) patients are at high risk of cardiac death. Coincidental but silent coronary disease is obviously a major contributor but left ventricular hypertrophy (LVH) could be a second major contributor...
  81. ncbi request reprint Letter by Struthers et al regarding article, "cross-sectional relations of multiple biomarkers from distinct biological pathways to brachial artery endothelial function"
    Allan D Struthers
    Circulation 114:e383; author reply e384. 2006
  82. ncbi request reprint The neurohormonal natural history of essential hypertension: towards primary or tertiary aldosteronism?
    Pitt O Lim
    Department of Cardiology, Wales Heart Research Institute, University of Wales College of Medicine, Heath Park, Cardiff CF14 4XN, Wales, UK
    J Hypertens 20:11-5. 2002
    ....
  83. pmc Introducing a new role for BNP: as a general indicator of cardiac structural disease rather than a specific indicator of systolic dysfunction only
    Allan D Struthers
    Heart 87:97-8. 2002
  84. ncbi request reprint Long-term follow-up of very old heart failure patients enrolled in a trial of exercise training
    Miles D Witham
    Section of Ageing and Health, University of Dundee, Ninewells Hospital, UK
    Am J Geriatr Cardiol 16:243-8. 2007
    ..6 m/month in nonattenders; P=.03). Similar results were seen for other outcomes. Only a small proportion of the variance in change of any of the outcomes was explained by differences in baseline variables...
  85. ncbi request reprint The cardiovascular risk factor, left ventricular hypertrophy, is highly prevalent in stable, treated angina pectoris
    Donald Swee Cheng Ang
    Division of Medicine and Therapeutics, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK
    Am J Hypertens 20:1029-35. 2007
    ..However, LVH will only have a large impact overall in CAD if it is highly prevalent. Therefore we aimed to assess the prevalence of LVH in patients with stable, treated angina and its relationship with blood pressure (BP)...
  86. ncbi request reprint Spironolactone has antiarrhythmic activity in ischaemic cardiac patients without cardiac failure
    Nimit C Shah
    J Hypertens 25:2345-51. 2007
    ..To examine whether endogenous aldosterone can cause either arrhythmias (and some of their underlying mechanisms) or endothelial dysfunction in patients with coronary artery disease (CAD) but without heart failure...
  87. ncbi request reprint Evaluation of the aldosterone-blocking agent eplerenone in hypertension and heart failure
    Jacob George
    Ninewells Hospital, Department of Clinical Pharmacology, Level 7, Dundee DD1 9SY, Scotland, UK
    Expert Opin Pharmacother 8:3053-9. 2007
    ..This article reviews the pathophysiology of aldosterone and critically reviews the present evidence for the efficacy and potential role for the new selective aldosterone-receptor antagonist, eplerenone...
  88. doi request reprint Adverse cardiovascular effects of acute salt loading in young normotensive individuals
    Nikolaos Tzemos
    Hypertension Research Centre, Division of Medicine and Therapeutics, University of Dundee, Ninewells Hospital and Medical School, United Kingdom
    Hypertension 51:1525-30. 2008
    ..02). Salt loading impaired vascular endothelial function, left ventricular mechanical relaxation, and electric repolarization in young healthy normotensives...
  89. pmc Effect of perindopril on physical function in elderly people with functional impairment: a randomized controlled trial
    Deepa Sumukadas
    Section of Ageing and Health, University of Dundee, Dundee, UK
    CMAJ 177:867-74. 2007
    ..We sought to examine the effect of the angiotensin-converting-enzyme (ACE) inhibitor perindopril on physical function in elderly people with functional impairment who had no heart failure or left ventricular systolic dysfunction...
  90. ncbi request reprint The influence of mode of delivery and ACE genotype on serum angiotensin converting enzyme (ACE) activity in the mother and infant at term
    Ramalingam Uma
    Division of Maternal and Child Health Sciences, University of Dundee, Dundee, United Kingdom
    Eur J Obstet Gynecol Reprod Biol 134:179-83. 2007
    ..Hence the aim of this study was to assess serum ACE activity and its genotype in mothers and infants at term in relation to labour and mode of delivery...
  91. ncbi request reprint Effects of an exercise intervention for older heart failure patients on caregiver burden and emotional distress
    Gerard J Molloy
    School of Psychology, University of Aberdeen, Aberdeen, Scotland, UK
    Eur J Cardiovasc Prev Rehabil 13:381-7. 2006
    ..The impact of exercise programmes for heart failure on those close to the patient is largely unknown. We examined the effect of a hospital and home-based exercise intervention on burden, anxiety and depression of informal caregivers...
  92. ncbi request reprint Effect of spironolactone on C-reactive protein levels in patients with heart disease
    Valerie Godfrey
    Int J Cardiol 117:282-4. 2007
    ..These studies provide evidence against the hypothesis that the clinical benefits produced by aldosterone blockade are due to it having anti-inflammatory effects...
  93. ncbi request reprint Exercise capacity and brain natruiretic peptide in hypertension
    Pitt O Lim
    Department of Cardiology, Wales Heart Research Institute, University of Wales College of Medicine, Heath Park, Cardiff, United Kingdom
    J Cardiovasc Pharmacol 40:519-27. 2002
    ..In Conclusion, BNP may potentially act as a homeostatic mechanism that helps to limit exercise incapacity in hypertension irrespective of LVH...
  94. pmc Tolerability of spironolactone in patients with chronic heart failure -- a cautionary message
    Miles D Witham
    Section of Ageing and Health, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
    Br J Clin Pharmacol 58:554-7. 2004
    ..To assess how well heart failure patients tolerate spironolactone in routine clinical practice...
  95. ncbi request reprint Myocardial production of C-type natriuretic peptide in chronic heart failure
    Paul R Kalra
    Clinical Cardiology, National Heart and Lung Institute, London, UK
    Circulation 107:571-3. 2003
    ..We assessed the hypothesis that CNP is produced by the heart in patients with CHF...
  96. ncbi request reprint Pulse wave analysis and pulse wave velocity: a critical review of their strengths and weaknesses
    Justine Ina Davies
    Department of Clinical Pharmacology, Ninewells Hospital and Medical School, Dundee DD1 9SY, Scotland, UK
    J Hypertens 21:463-72. 2003
    ..Importantly, use of the technique of applanation tonometry to derive the central waveform from non-invasively acquired peripheral data needs to be validated prospectively...
  97. ncbi request reprint Tonic levels of angiotensin II reduce tonic levels of vascular nitric oxide even in salt-replete man
    Justein S N Sim
    Division of Medicine and Therapeutics, Ninewells Hospital and Medical School, Dundee, UK
    J Renin Angiotensin Aldosterone Syst 5:84-8. 2004
    ..If so, this would imply that tonic levels of angiotensin II (Ang II) reduce tonic basal levels of NO, even in salt-replete normal man...
  98. ncbi request reprint Age is not a significant risk factor for failed trial of beta-blocker therapy in older patients with chronic heart failure
    Miles D Witham
    Section of Ageing and Health, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
    Age Ageing 33:467-72. 2004
    ..To evaluate how well older heart failure patients tolerate beta-blockers in everyday clinical practice...
  99. ncbi request reprint How much echo left ventricular hypertrophy would be missed in diabetics by applying the Losartan Intervention For Endpoint Reduction electrocardiogram criteria to select patients for angiotensin receptor blockade?
    Adelle Dawson
    Department of Clinical Pharmacology and Therapeutics, Ninewells Hospital, Dundee, UK
    J Hypertens 22:1403-8. 2004
    ..We sought to determine how many cases of echo LVH would be missed by applying the ECG criteria for LVH used in the LIFE study...
  100. ncbi request reprint Peripheral blood pressure measurement is as good as applanation tonometry at predicting ascending aortic blood pressure
    Justine I Davies
    Department of Clinical Pharmacology, Department of Cardiology and Department of Epidemiology and Public Health, Ninewells Hospital and Medical School, Dundee DD1 9SY, Scotland, UK
    J Hypertens 21:571-6. 2003
    ..It has been shown to be accurate when data obtained invasively are used, but has not been tested prospectively using data obtained non-invasively...
  101. ncbi request reprint Are elderly people with the HOPE criteria prescribed angiotensin-converting enzyme inhibitors?
    Deepa Sumukadas
    Department of Medicine and Therapeutics, University of Dundee, Ninewells Hospital and Medical School, Dundee, DD1 9SY, UK
    J Renin Angiotensin Aldosterone Syst 5:26. 2004